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1

Gao, Junling, and 高峻岭. "Neural basis of prospective memory in normal and abnormal ageing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44530195.

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2

Zicha, Stephen. "Molecular basis for ion current heterogeneity in normal and diseased hearts." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85660.

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Cardiac action potential characteristics are known to vary in different species, but also in the different regions of the heart within a given species and in cardiovascular disease. The heterologous expression of voltage-gated ion currents is believed to underlie these differences. The purpose of this thesis is to elucidate the molecular mechanisms which may underlie some of the observed current changes in different species, as well as regions and diseases of the heart.
Here, we describe the variable dependence on repolarizing K+ currents in different species as being the result of the lack of Ito subunits in guinea pig heart with a greater expression of IK subunits, while rabbits express all hypothesized Ito subunits, but express IK subunits at low levels. Humans are found to lie in between these two species in terms of the expression of these voltage-gated K+ channel subunits. The specialized function of certain regions of the heart, such as the ventricles and the SAN, have been attributed to the heterologous expression of Ito and the pacemaker current (I f) respectively. Here were demonstrate that both Kv4.3 and KchIP2 gradients underlie an observed Ito transmural gradient and contribute to the dispersion of repolarization, while a greater expression of HCN2 and HCN4 subunits in the SAN compared to the right atrium account for the larger I f current in this region. Cardiovascular diseases such as congestive heart failure (CHF) have been associated with ion channel remodelling. Here, we report the finding of changes in Nav1.5, Kv4.3, HCN2 and HCN4 expression which may underlie some of the electrophysiological changes associated with this disease. Furthermore, we characterise a genetic polymorphism which is associated with another disease, atrial fibrillation.
The heterologous expression of voltage-gated ion channel subunits may account for many of the species-, region- and disease-specific differences which have been observed in the heart. Such heterogeneity contributes to the proper functioning of the heart under normal conditions, but may also contribute to the pathogenesis of cardiovascular disease.
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3

高木, 直史, and Naofumi Takagi. "A fast algorithm for multiplicative inversion in GF(2m) using normal basis." IEEE, 2001. http://hdl.handle.net/2237/5292.

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4

Abrahamsson, Björn. "Architectures for Multiplication in Galois Rings." Thesis, Linköping University, Department of Electrical Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2396.

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This thesis investigates architectures for multiplying elements in Galois rings of the size 4^m, where m is an integer.

The main question is whether known architectures for multiplying in Galois fields can be used for Galois rings also, with small modifications, and the answer to that question is that they can.

Different representations for elements in Galois rings are also explored, and the performance of multipliers for the different representations is investigated.

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5

Graf, Justin T. "Membrane associated transporter protein gene (SLC45A2) and the genetic basis of normal human pigmentation variation." Queensland University of Technology, 2008. http://eprints.qut.edu.au/25913/.

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This work is concerned with the genetic basis of normal human pigmentation variation. Specifically, the role of polymorphisms within the solute carrier family 45 member 2 (SLC45A2 or membrane associated transporter protein; MATP) gene were investigated with respect to variation in hair, skin and eye colour ― both between and within populations. SLC45A2 is an important regulator of melanin production and mutations in the gene underly the most recently identified form of oculocutaneous albinism. There is evidence to suggest that non-synonymous polymorphisms in SLC45A2 are associated with normal pigmentation variation between populations. Therefore, the underlying hypothesis of this thesis is that polymorphisms in SLC45A2 will alter the function or regulation of the protein, thereby altering the important role it plays in melanogenesis and providing a mechanism for normal pigmentation variation. In order to investigate the role that SLC45A2 polymorphisms play in human pigmentation variation, a DNA database was established which collected pigmentation phenotypic information and blood samples of more than 700 individuals. This database was used as the foundation for two association studies outlined in this thesis, the first of which involved genotyping two previously-described non-synonymous polymorphisms, p.Glu272Lys and p.Phe374Leu, in four different population groups. For both polymorphisms, allele frequencies were significantly different between population groups and the 272Lys and 374Leu alleles were strongly associated with black hair, brown eyes and olive skin colour in Caucasians. This was the first report to show that SLC45A2 polymorphisms were associated with normal human intra-population pigmentation variation. The second association study involved genotyping several SLC45A2 promoter polymorphisms to determine if they also played a role in pigmentation variation. Firstly, the transcription start site (TSS), and hence putative proximal promoter region, was identified using 5' RNA ligase mediated rapid amplification of cDNA ends (RLM-RACE). Two alternate TSSs were identified and the putative promoter region was screened for novel polymorphisms using denaturing high performance liquid chromatography (dHPLC). A novel duplication (c.–1176_–1174dupAAT) was identified along with other previously described single nucleotide polymorphisms (c.–1721C>G and c.–1169G>A). Strong linkage disequilibrium ensured that all three polymorphisms were associated with skin colour such that the –1721G, +dup and –1169A alleles were associated with olive skin in Caucasians. No linkage disequilibrium was observed between the promoter and coding region polymorphisms, suggesting independent effects. The association analyses were complemented with functional data, showing that the –1721G, +dup and –1169A alleles significantly decreased SLC45A2 transcriptional activity. Based on in silico bioinformatic analysis that showed these alleles remove a microphthalmia-associated transcription factor (MITF) binding site, and that MITF is a known regulator of SLC45A2 (Baxter and Pavan, 2002; Du and Fisher, 2002), it was postulated that SLC45A2 promoter polymorphisms could contribute to the regulation of pigmentation by altering MITF binding affinity. Further characterisation of the SLC45A2 promoter was carried out using luciferase reporter assays to determine the transcriptional activity of different regions of the promoter. Five constructs were designed of increasing length and their promoter activity evaluated. Constitutive promoter activity was observed within the first ~200 bp and promoter activity increased as the construct size increased. The functional impact of the –1721G, +dup and –1169A alleles, which removed a MITF consensus binding site, were assessed using electrophoretic mobility shift assays (EMSA) and expression analysis of genotyped melanoblast and melanocyte cell lines. EMSA results confirmed that the promoter polymorphisms affected DNA-protein binding. Interestingly, however, the protein/s involved were not MITF, or at least MITF was not the protein directly binding to the DNA. In an effort to more thoroughly characterise the functional consequences of SLC45A2 promoter polymorphisms, the mRNA expression levels of SLC45A2 and MITF were determined in melanocyte/melanoblast cell lines. Based on SLC45A2’s role in processing and trafficking TYRP1 from the trans-Golgi network to stage 2 melanosmes, the mRNA expression of TYRP1 was also investigated. Expression results suggested a coordinated expression of pigmentation genes. This thesis has substantially contributed to the field of pigmentation by showing that SLC45A2 polymorphisms not only show allele frequency differences between population groups, but also contribute to normal pigmentation variation within a Caucasian population. In addition, promoter polymorphisms have been shown to have functional consequences for SLC45A2 transcription and the expression of other pigmentation genes. Combined, the data presented in this work supports the notion that SLC45A2 is an important contributor to normal pigmentation variation and should be the target of further research to elucidate its role in determining pigmentation phenotypes. Understanding SLC45A2’s function may lead to the development of therapeutic interventions for oculocutaneous albinism and other disorders of pigmentation. It may also help in our understanding of skin cancer susceptibility and evolutionary adaptation to different UV environments, and contribute to the forensic application of pigmentation phenotype prediction.
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6

Silva, Márcio Antônio. "A formação dos professores no curso normal superior na perspectiva pós-LDBEN : um balanço crítico." Universidade Federal de São Carlos, 2008. https://repositorio.ufscar.br/handle/ufscar/2221.

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Financiadora de Estudos e Projetos
The purpose of this study is to examine the participation of the State University of Montes Claros (UNIMONTES) in the context of education policies of the country as regards its participation and proposition of training teachers in the Superior Normal mode in the post- LDBEN. Delineamos object of study as the training of teachers of the course Normal Superior / Modular offered by UNIMONTES. I reviewed the theoretical assumptions and economic education in the proposals of neoliberal Miltom Friedrick Hayek and Friedman. This study if it bases on the contributions of Karl Marx. The methodology is guided by qualitative research-quantitative, combining data: questionnaires, interviews, official documents of the course Normal Superior, matches of students and production of texts. The considerations possible, this research is that UNIMONTES, contributed to the access of a significant contingent of teachers of elementary school, following the decisions of LDBEN 9394/96. However, the university changes its role in training teachers when relegates to the background the course of teaching that has historical tradition in the training of professional education in the north of Minas.
O objetivo deste estudo é analisar a participação da Universidade Estadual de Montes Claros (UNIMONTES) no contexto das políticas de educação do país, no que se refere a sua participação e proposição de programas de formação de professores na modalidade Normal Superior no cenário pós-LDBEN. Delineamos como objeto de estudo a formação de professores do curso Normal Superior/Modular oferecido pela UNIMONTES. Analiso a origem da universidade, crises, tensões e desafios para preservar sua identidade e as repercussões históricas na universidade contemporânea no Brasil. A metodologia orientou-se pela pesquisa qualitativo-quantitativa, conjugando os dados: questionários, entrevistas, documentos oficiais do curso Normal Superior, correspondências de alunos e produção de textos. As considerações possíveis, a partir desta investigação, é a de que a UNIMONTES contribuiu com o acesso de um contingente significativo de professores do ensino fundamental, obedecendo às determinações da LDBEN 9394/96. Entretanto, a universidade altera o seu papel na formação de professores quando o relega a segundo plano o curso de Pedagogia, que tem tradição histórica na formação de profissionais da educação no norte de Minas.
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7

Duarte, Andrés Daniel. "Nash modification on toric surfaces and higher Nash blowup on normal toric varieties." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2127/.

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Dans la première partie de la thèse on étudie un algorithme combinatoire qui correspond à l'itération de la modification de Nash d'une variété torique. On montre que, dans le cas de la dimension deux, cet algorithme s'arrête pour certains choix de cartes affines de la modification de Nash. De plus, on donne une borne pour le nombre d'itérations nécessaire pour que l'algorithme s'arrête dans les cas que l'on considère. Soit C(x_1,x_2) le corps des fonctions d'une surface torique. Alors notre résultat implique que pour toute valuation v centrée sur la surface torique tel que v(x_1) n'est pas un multiple irrationnel de v(x_2), une itération finie de la modification de Nash donne une uniformisation locale le long de cette valuation. Dans la deuxième partie on étudie la notion d'éclatement de Nash supérieur d'une variété algébrique. Cette notion consiste à remplacer des points singuliers par des limites de certains espaces vectoriels associés aux points non singuliers de la variété. On donne une description combinatoire de l'éclatement de Nash supérieur dans le cas de variétés toriques normales. En utilisant cette description, on montre que l'analogue du théorème de Nobile sur l'éclatement de Nash usuel est aussi valide dans ce contexte. Plus précisément, on montre que pour une variété torique normale, l'éclatement de Nash supérieur est un isomorphisme si et seulement si la variété est non singulière
In the first part of the thesis we explore a combinatorial algorithm that corresponds to the iteration of Nash modification on not necessarily normal toric varieties. We show that for toric surfaces this algorithm stops for certain choices of affine charts of the Nash modification. In addition, we give a bound on the number of steps required for the algorithm to stop in the cases we consider. Let C(x_1,x_2) be the field of rational functions of a toric surface. Then our result implies that for any valuation v centered on the toric surface such that v(x_1) is not an irrational multiple of v(x_2), a finite iteration of Nash modification gives local uniformization along this valuation. In the second part of the thesis we explore the notion of higher Nash blowup of an algebraic variety which is a modification that replaces singular points with limits of certain spaces carrying higher order data associated to the variety at non-singular points. In the case of normal toric varieties we give a combinatorial description of the higher Nash blowup in terms of a Groebner fan. This description allow us to prove the analogous of Nobile's theorem on the usual Nash blowup in this context. More precisely, we prove that for a normal toric variety, the higher Nash blowup is an isomorphism if and only if the variety is non-singular
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8

Fernando, Neranga. "A Study of Permutation Polynomials over Finite Fields." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4484.

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Let p be a prime and q = pk. The polynomial gn,q isin Fp[x] defined by the functional equation Sigmaa isin Fq (x+a)n = gn,q(xq- x) gives rise to many permutation polynomials over finite fields. We are interested in triples (n,e;q) for which gn,q is a permutation polynomial of Fqe. In Chapters 2, 3, and 4 of this dissertation, we present many new families of permutation polynomials in the form of gn,q. The permutation behavior of gn,q is becoming increasingly more interesting and challenging. As we further explore the permutation behavior of gn,q, there is a clear indication that gn,q is a plenteous source of permutation polynomials. We also describe a piecewise construction of permutation polynomials over a finite field Fq which uses a subgroup of Fq*, a “selection” function, and several “case” functions. Chapter 5 of this dissertation is devoted to this piecewise construction which generalizes several recently discovered families of permutation polynomials.
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9

Vidal, Luciano Nassif. "Desenvolvimento de metodologias para o estudo do efeito Raman normal e ressonante utilizando modelos Ab initio dependentes do tempo." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249083.

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Orientador: Pedro Antonio Muniz Vazquez
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica
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Resumo: O presente trabalho aborda o desenvolvimento de metodologias para o cálculo das intensidades absolutas do espalhamento Raman vibracional produzido por moléculas em fase gasosa. Com o objetivo de reduzir a demanda por recursos computacionais nestes cálculos, foram desenvolvidas duas novas famílias de funções de base compactas pela aplicação do método de polarização elétrica de Sadlej às bases para uso com potenciais efetivos de caroço SBKJC e de Stuttgart-Colônia. Utilizando estas novas funções de base, as intensidades Raman podem ser obtidas com a mesma qualidade das bases Sadlej-pVTZ, que são referência no cálculo destas propriedades, porém com um custo computacional sensivelmente menor. Além disso, como estes pseudopotenciais foram modelados para descrever os efeitos relativísticos sobre os elétrons internos, as polarizabilidades e intensidades Raman obtidas no nível Hartree-Fock com estas novas bases concordam, dentro de um erro médio de 6%, com seus respectivos valores relativísticos Dirac-Hartree-Fock/Sadlei-pVTZ com hamiltoniano de Dirac-Coulomb. Também foi desenvolvida uma metodologia para o estudo das intensidades das transições Raman fundamentais, de combinação e sobretom, que inclui as correções para a anarmonicidade cúbica do potencial, introduzidas através de uma transformação de contato. Os resultados obtidos para a molécula de acetileno e seus isotopômeros deuterados mostram que a anarmonicidade mecânica exerce grande influência sobre as intensidades Raman, particularmente das transições de segunda ordem. Excetuando as transições de combinação, em geral, as correções de anarmoniciadade melhoram a concordância dos valores teóricos com os experimentais. Uma terceira parte deste trabalho trata do efeito Raman em condições ressonantes, onde uma expressão para estas intensidades foi derivada, implementada no programa PLACZEK e aplicada no cálculo do espectro Raman da molécula de trans-butadieno nas vizinhanças de sua transição eletrônica 1Bu. Este estudo mostrou que as aproximações utilizadas com maior frequência para simplificar o cálculo desta propriedade afetam significativamente as seções de choque desta molécula, sugerindo que estas aproximações devem ser evitadas em estudos desta natureza.
Abstract: In this work new methodologies for the calculation of absolute vibrational Raman intensities of gaseous systems are presented. In order to reduce the computational requirements in these calculations two families of compact basis functions were generated from the effective core potential valence basis sets SBKJC and Stuttgart-Cologne through the Sadlej's electric polarization procedure. The Raman intensities evaluated with the new bases are close to those obtained with the well successful Sadlej-pVTZ basis but the computational requirements are significatively reduced. Furthermore, since the effective core potentials SBKJC and Stuttgart-Cologne were developed to account for the relativistic effects on the inner electrons, the polarizabilities and Raman intensities evaluated at the Hartree-Fock level with the new bases agree with the relativistic Dirac-Hartree-Fock values, obtained using the Dirac-Coulomb Hamiltonian and the Sadlej-pVTZ set, within the mean error of 6%. In the second part of this work a methodology was developed for the study of fundamental, combination and overtone Raman transitions including a treatment based on the contact transform formalism for the mechanical anharmonicity from the cubic potential energy terms. The results obtained for acetylene and its deutered isotopomers show that anharmonicity effects on the Raman intensities can be very strong, particularly in the second order transitions. With the exception of the combination transitions, in general the corrections for mechanical anharmonicity improve the agreement between ab initio and experimental values. The resonance Raman scattering is the subject of the third part of this work where an expression for the resonance cross section was derived, implemented in the PLACZEK program and applied to the calculation of the resonance Raman spectrum of the trans-butadiene molecule in the region of its.
Doutorado
Físico-Química
Doutor em Ciências
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10

Schillings, Christoph. "Bestimmung langjähriger stündlicher Zeitreihen und räumlich hochaufgelöster Karten der Direkt-Normal-Strahlung auf der Basis von Meteosat-Daten und Atmosphärenparametern für die Nutzung in konzentrierenden Solarkraftwerken." [S.l. : s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0623/.

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11

Santana, Ribeiro Magalhães Pedro José [Verfasser], Lars [Akademischer Betreuer] Pape, and Andreas [Akademischer Betreuer] Kispert. "Unravelling molecular basis of normal and abnormal renal tract : a proteomic approach / Pedro José Santana Ribeiro Magalhães ; Akademische Betreuer: Lars Pape, Andreas Kispert ; Klinik für Pädiatrische Nieren-, Leber- und Stoffwechselerkrankungen." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2018. http://d-nb.info/117345313X/34.

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12

Shao, Qiliang. "FPGA Realization of Low Register Systolic Multipliers over GF(2^m)." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1481808131971019.

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13

Mello, Thiago Castilho de. "Sobre bases normais para extensões galoisianas de corpos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-21052008-150202/.

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Neste trabalho apresentamos várias demonstrações do Teorema da Base Normal para certos tipos de extensões galoisianas de corpos, algumas existenciais e outras construtivas, destacando as diferenças e dificuldades de cada situação. Apresentamos também generalizações de tal teorema e mostramos que toda extensão galoisiana de grau ímpar de corpos admite uma base normal autodual com respeito µa forma bilinear traço
In this work we present several demonstrations of The Normal Basis Theorem for certain kinds of galoisian extensions of fields, some of them existential and others constructive, pointing the diffculties and differences in each situation. We also present generalizations of such theorem and show that every odd degree galoisian extension of fields admits a self-dual normal base with respect to the trace bilinear map
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Lülf, Fritz Adrian. "An integrated method for the transient solution of reduced order models of geometrically nonlinear structural dynamic systems." Phd thesis, Conservatoire national des arts et metiers - CNAM, 2013. http://tel.archives-ouvertes.fr/tel-00957455.

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For repeated transient solutions of geometrically nonlinear structures the numerical effort often poses a major obstacle. Thus, the introduction of a reduced order model, which takes the nonlinear effects into account and accelerates the calculations considerably, is often necessary.This work yields a method that allows for rapid, accurate and parameterisable solutions by means of a reduced model of the original structure. The structure is discretised and its dynamic equilibrium described by a matrix equation. The projection on a reduced basis is introduced to obtain the reduced model. A comprehensive numerical study on several common reduced bases shows that the simple introduction of a constant basis is not sufficient to account for the nonlinear behaviour. Three requirements for an rapid, accurate and parameterisable solution are derived. The solution algorithm has to take into account the nonlinear evolution of the solution, the solution has to be independent of the nonlinear finite element terms and the basis has to be adapted to external parameters.Three approaches are provided, each responding to one requirement. These approaches are assembled to the integrated method. The approaches are the update and augmentation of the basis, the polynomial formulation of the nonlinear terms and the interpolation of the basis. A Newmark-type time-marching algorithm provides the frame of the integrated method. The application of the integrated method on test-cases with geometrically nonlinear finite elements confirms that this method leads to the initial aim of a rapid, accurate and parameterisable transient solution.
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Silva, Juan Carlo da Cruz. "Sobre operadores entre espaços de sequências que atingem a norma." Universidade Federal da Paraí­ba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/7420.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
In this work we present a recent result, due to D. Pellegrino and E. V. Teixeira, that characterizes the continuous linear operators between lpspaces which attain their norms. To this end, we Örstly explore some topics from the Banach space theory, such as Banachís Theorem for basis, Bessaga-Pe ̃czynski Selection Principle and Pittís Theorem.
Neste trabalho apresentaremos um recente resultado, devido a D. Pellegrino e E. V. Teixeira, que caracteriza os operadores lineares contínuos entre espaços lp que atingem a norma. Para tanto, vamos desenvolver alguns tópicos da teoria de bases em espaços de Banach e também mostrar alguns importantes resultados da teoria de espaços de Banach, tais como o Teorema de Banach sobre bases, o Princípio de Seleção de Bessaga- Pe÷czy´nski e o Teorema de Pitt.
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Radon, Johannes [Verfasser]. "Die Betreuungsqualität in den letzten beiden Lebenstagen auf der Palliativ-, Normal- und Intensivstation aus Sicht der Angehörigen - eine Studie an zwei Standorten auf der Basis des CODE (Care of the Dying Evaluation) - Fragebogens / Johannes Radon." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1237814529/34.

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17

Robertson, Angela May. "Normal bases and compactifications of frames." Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/18247.

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The initial aim of this dissertation was to provide a frame-theoretic analogue of Banaschewski's normal systems of sets in [5] as well as a frame counterpart to their associated compactifications. Having completed this part of the task, it seemed natural to investigate the relationship between this compactification and those mentioned above. Hence the first five chapters of the dissertation are devoted to the study of the frame counterparts to six well-known compactifications in the category of topological spaces. For each compactification studied, we give some motivation as to why it should be regarded as a frame-theoretic analogue of its classical counterpart. The sixth chapter is concerned with the relationships between the compactifications: in particular we are interested in conditions under which the different constructions give rise to the same compactification.
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Guthrie, Kristin M. "Structural controls on extensional-basin development triassic Ischigualasto Formation, NW Argentina." Connect to this document online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1123266742.

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Thesis (M.S.)--Miami University, Dept. of Geology, 2005.
Title from first page of PDF document. Document formatted into pages; contains [1], iv, 38 p. : ill. Includes bibliographical references (p. 35-38).
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Coutinho, Sávio da Silva. "Sobre a existência ou não de bases normais auto-duais para extensões galoisianas de corpos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-18052009-150619/.

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Neste trabalho, apresentamos um estudo sobre a existência ou não de bases normais auto-duais para extensões galoisianas finitas de corpos, mostrando que toda extensão galoisiana finita de grau ímpar posui uma base normal auto-dual, enquanto que para extensões galoisianas de grau par, apresentamos algumas condições suficientes que garantem a não existência de bases normais auto-duais
In this work, we present a study about the existence or not of self-dual normal bases for finite galoisian extensions of fields, showing that all the odd degree finite galoisian extension has a self-dual normal base, whereas for even degree galoisian extensions, we present some sufficient conditions that assure the non-existence of self-dual normal bases
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Tizziotti, Guilherme Chaud. "Codificação de certos codigos de Goppa geometricos utilizando a teoria de Bases de Grobner e codigos sobre a curva Norma-Traço." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/307072.

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Orientador: Fernando Eduardo Torres Orihuela
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica
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Resumo: Estendemos resultados de Heegard, Little e Saints relacionados a bases de Gröbner para códigos Hermitianos pontuais. Trabalhamos com códigos Hermitianos bipontuais e n-pontuais, e com códigos sobre a curva Norma-Traço. Além disso, determinamos o semigrupo de Weierstrass de um certo par de pontos racionais sobre a curva Norma-Traço e com esse semigrupo conseguimos melhorar a cota da distância mínima de códigos construídos sobre tais curvas
Abstract: We extend results of Heegard, Little and Saints concerning the Gröbner basis algorithm for one-point Hermitian codes. We work with two-point and n-point Hermitian codes and codes arising from the Norm-Trace curve. We also determine the Weierstrass semigroup at a certain pair of rational points in such curves and uses these computations to improve the lower bound on the minimum distance of two-point algebraic geometry codes arising from them
Doutorado
Algebra, Geometria Algebrica
Doutor em Matemática
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Carlson, Stephen J. "Normal bases in class fields over real abelian number fields /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9835369.

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22

Benki, Aalae. "Méthodes efficaces de capture de front de pareto en conception mécanique multicritère : applications industrielles." Phd thesis, Université Nice Sophia Antipolis, 2014. http://tel.archives-ouvertes.fr/tel-00959099.

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Dans le domaine d'optimisation de forme de structures, la réduction des coûts et l'amélioration des produits sont des défis permanents à relever. Pour ce faire, le procédé de mise en forme doit être optimisé. Optimiser le procédé revient alors à résoudre un problème d'optimisation. Généralement ce problème est un problème d'optimisation multicritère très coûteux en terme de temps de calcul, où on cherche à minimiser plusieurs fonctions coût en présence d'un certain nombre de contraintes. Pour résoudre ce type de problème, on a développé un algorithme robuste, efficace et fiable. Cet algorithme, consiste à coupler un algorithme de capture de front de Pareto (NBI ou NNCM) avec un métamodèle (RBF), c'est-à-dire des approximations des résultats des simulations coûteuses. D'après l'ensemble des résultats obtenus par cette approche, il est intéressant de souligner que la capture de front de Pareto génère un ensemble des solutions non dominées. Pour savoir lesquelles choisir, le cas échéant, il est nécessaire de faire appel à des algorithmes de sélection, comme par exemple Nash et Kalai-Smorodinsky. Ces deux approches, issues de la théorie des jeux, ont été utilisées pour notre travail. L'ensemble des algorithmes sont validés sur deux cas industriels proposés par notre partenaire industriel. Le premier concerne un modèle 2D du fond de la canette (elasto-plasticité) et le second est un modèle 3D de la traverse (élasticité linéaire). Les résultats obtenus confirment l'efficacité de nos algorithmes développés.
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23

Quttineh, Nils-Hassan. "Computational Complexity of Finite Field Multiplication." Thesis, Linköping University, Department of Electrical Engineering, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1968.

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The subject for this thesis is to find a basis which minimizes the number of bit operations involved in a finite field multiplication. The number of bases of a finite field increases quickly with the extension degree, and it is therefore important to find efficient search algorithms. Only fields of characteristic two are considered.

A complexity measure is introduced, in order to compare bases. Different methods and algorithms are tried out, limiting the search in order to explore larger fields. The concept of equivalent bases is introduced.

A comparison is also made between the Polynomial, Normal and Triangular Bases, referred to as known bases, as they are commonly used in implementations. Tables of the best found known bases for all fields up to GF(2^24) is presented.

A list of the best found bases for all fields up to GF(2^25) is also given.

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24

Bolelli, Maria Virginia. "Basi di Campi Finiti." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11443/.

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Questo elaborato si propone di approfondire lo studio dei campi finiti, in modo particolare soffermandosi sull’esistenza di una base normale per un campo finito, in quanto l'utilizzo di una tale base ha notevoli applicazioni in ambito crittografico. ​Vengono trattati i seguenti argomenti: elementi di base della teoria dei campi finiti, funzione traccia e funzione norma, basi duali, basi normali. Vengono date due dimostrazioni del Teorema della Base Normale, la seconda delle quali fa uso dei polinomi linearizzati ed è in realtà un po' più generale, in quanto si riferisce ai q-moduli.​
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25

Gomez, Ayala Eugenio Jesus. "Bases normales d'entiers et multiplication complexe." Bordeaux 1, 1991. http://www.theses.fr/1991BOR10531.

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Dans les trois articles qui composent cette these on s'interesse a la generalisation possible, dans le cadre de la multiplication complexe, du theoreme de leopoldt pour la structure galoisienne des anneaux d'entiers d'extensions de kummer, moderement ramifiees, de corps de nombres
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26

Lewis, Matthew Marchant. "Structural style and stratigraphic response to normal fault growth in extensional basins." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/38447.

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The early growth of normal faults is typically associated with the development of at-surface monoclinal folds and the deposition of wedge shaped syn-rift deposits that typically thin and onlap towards these growth structures. This is especially true in salt-influenced rift basins, where the presence of mechanically-weak, evaporite rich units within the pre-rift succession may serve to decouple folded supra-salt strata from faulted sub-salt strata, resulting in the formation of extensional forced folds in the overburden. However, uncertainties still exist with respect to; (i) the controls of the structural style and kinematics of normal fault growth in salt-influenced rifts; (ii) the syn-rift stratigraphic response to faulting and folding; and (iii) the along-strike variability of these linked structural and stratigraphic relationships in both salt-influenced and non-salt influenced extensional settings. To address these outstanding research issues, an integrated dataset of three-dimensional seismic reflection and borehole data from the Stavanger Fault System (SFS), Egersund Basin, North Sea and field data from the Hadahid Fault System (HFS), Suez Rift, Egypt is used. The results demonstrate that; (i) the structural style of fault growth in salt-influenced basins is primary controlled by the pre-rift salt distribution and thickness, and that the sub- and supra-salt fault populations initiate and grow as brittle elements of a single, geometrically and kinematically coherent structure; (ii) the stratal architecture of and facies variations in early syn-rift deposits are controlled by the growth of normal faults and extensional forced folding, and changes in base-level; and (iii) the along-strike variability in the stratal architecture of and facies variations in early syn-rift deposits are influenced by growth folding and faulting, which may vary markedly in time and space at both the fault-segment and fault-system scales.
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27

Linfoot, Andy James. "A Case Study of A Multithreaded Buchberger Normal Form Algorithm." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/305141.

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Groebner bases have many applications in mathematics, science, and engineering. This dissertation deals with the algorithmic aspects of computing these bases. The dissertation begins with a brief introduction of fundamental concepts about Groebner bases. Following this a discussion of various implementation issues are discussed. Much of the practical difficulties of using Groebner basis algorithms and techniques stems from the high computational complexity. It is shown that the algorithmic complexity of computing a Groebner basis primarily stems from the calculation of normal forms. This is established by studying run profiles of various computations. This leads to two options of making Groebner basis techniques more practical. They are to reduce the complexity by developing new algorithms (heuristics) or reduce running time of normal form calculations by introducing concurrency. The later approach is taken in the remainder of the dissertation where a multithreaded normal form algorithm is presented and discussed. It is shown with a simple example that the new algorithm demonstrates a speedup and scalability. The algorithm also has the advantage of being completion strategy independent. We conclude with an outline of future research involving the new algorithm.
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28

Enfield, Mark Andrew. "The geometry of normal faults and basin development : northern Scotland and southern France." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47050.

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29

Dinha, Carolin. "Regulation of Ski co-repressor stability by TGF-β signaling in normal and tumorigenic hepatocytes." Thesis, Högskolan i Skövde, Institutionen för vård och natur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5319.

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Transforming growth factor beta (TGF-β) is a multifunctional cytokine that regulates cell differentiation, proliferation and migration depending on cell context. TGF-β has a growth inhibitory effect on epithelial cells via activation of Smad proteins (R-Smad/Co-Smad complex). TGF-β signaling is negatively regulated by the proto-oncogene Ski (Sloan Kettering Institute). Ski in turn is degraded by TGF-β signaling (Smads) via ubiquitin proteasome system. TGF-β acts like a tumor suppressor in early stages of cancer due to its inhibitory growth effect, but in late stages it acts like a tumor promoter. The main aim of this thesis was to study the regulation of corepressor Ski stability in normal and transformed hepatic cells by TGF-β signaling and Smad proteins as well as determine Ski protein subcellular localization by using immunoprecipitation and Western blot assays for these studies. The obtained data showed that the TGF-β/Smad signaling pathway caused a downregulation of Ski protein through its degradation via proteasome in HepG2 cells. In addition, the Ski protein levels were restored when Smads were restored in C9 and hepatocytes even though the activated Smads were still present. In the subcellular fractionation studies it was observed that Ski protein was mainly localized in the nucleus of HepG2 cells, whereas it was localized in both nucleus and cytoplasm in hepatocytes.  The presence of Ski in the cell cytoplasm could be explained because of low sensitivity in TGF-β signaling or translocation of Ski from nucleus to cytoplasm. C184M is a protein that binds to Ski in the cytoplasm and Ski in turn binds to Smads and inhibits their translocation from cytoplasm to nucleus, which in turn means inhibition of gene transcription that instead results in growth stimulation.
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30

Jamil, Daniel. "Laparoscopic bariatric surgery - The normal course of liver values after surgery. A prospective cohort study." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-58257.

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31

Sáez, del Pino José Miguel. ""Normativa nacional antisísmica en materia de construcción : bases y proyecciones"." Tesis, Universidad de Chile, 2011. http://www.repositorio.uchile.cl/handle/2250/111886.

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Memoria (licenciado en ciencias jurídicas y sociales)
Este trabajo se ha diseñado como una muestra de la normativa antisísmica que existe en nuestra legislación. Basándose en lo particular en lo que determina nuestra normativa urbanística general, entendiéndose por tal la ley y la ordenanza general de urbanismo y construcción. A lo anterior se le suman las normas técnicas que regulan el diseño sísmico de las edificaciones en nuestro país, la NCh 433 y la NCh 2369. Una vez desarrollado el estudio normativo, el trabajo hará un análisis comparativo entre los órganos fiscalizadores que estudian la correcta aplicación normativa en la materia. Posteriormente el trabajo hará un examen comparativo con realidades semejantes a las nuestras y cuales han sido los derroteros que han seguido. Finalmente se hará un estudio del desarrollo actual de nuestra legislación y las profundas modificaciones que se produjeron en nuestra normativa, con posterioridad al terremoto de Febrero del año 2010 y las conclusiones, que a juicio del autor, se pueden desprender del estudio presente de esta investigación.
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32

Witt, César. "Constraints on the tectonic evolution of the north andean block trailing tail : evolution of the gulf of Guyaquil-tumbes basin and the intermontane basins of the central ecuadorian andes." Paris 6, 2007. http://www.theses.fr/2007PA066061.

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L’évolution du bassin du Golfe de Guayaquil-Tumbes (BGGT) est contrôlée par une extension parallèle à la fosse qui résulte de l’échappement du Bloc Nord Andin (BNA) vers le nord. Cette extension de direction N-S est accommodée le long du plateau continental par une série de failles normales à faible pendage (les détachements de Posorja, Jambelí et Tumbes) pendant le Pléistocène inférieur. Au contraire, le long de la pente continentale, la subsidence commence au Miocène et est liée à un régime de subduction érosion. Ces deux régimes extensifs sont limités par un système de transfer placé le long de la zone de rupture de la pente continentale (i. E. Le système de failles de Domito et la faille du Banco Peru). Le détachement de Tumbes correspond à la faille principale qui contrôle l’évolution du BGGT. Il se prolonge probablement vers les structures pouvant correspondre à la frontière est du BNA le long des Andes équatoriens, là où la formation des bassins intramontagneux est également liée à l’échappement du BNA. Dans ce contexte les bassins de Santa Isabel et le BGGT semblent avoir évolués avec un scénario d’échappement tectonique similaire
The Gulf of Guayaquil-Tumbes basin (GGTB) evolution is controlled by the trench-parallel extension that results from the North Andean block (NAB) northward drifting. This N-S directed extension is accommodated along the shelf by low-angle detachment normal faults (the Posorja, Jambelí and Tumbes detachment systems) during Pleistocene. In contrast, along the continental margin E-W directed subsidence began in Miocene times produced by a subduction erosion regime working at depth. Both regimes are limited by a major transfer system roughly located at the continental margin shelf break extending from the Domito faults system to the Banco Peru fault. The Tumbes detachment system corresponds to the master fault of basin evolution. It probably connects with the continental structures assumed to define part of the eastern frontier of the NAB, where intermontane basin formation along the central Ecuadorian Andes is also related to NAB drifting. In this discrete basin formation setting the Santa Isabel basin and the GGTB seem to have evolved along the same escape tectonic scenario
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Ramos, Alberto Gil Couto Pimentel. "Numerical solution of Sturm–Liouville problems via Fer streamers." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/256997.

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The subject matter of this dissertation is the design, analysis and practical implementation of a new numerical method to approximate the eigenvalues and eigenfunctions of regular Sturm–Liouville problems, given in Liouville’s normal form, defined on compact intervals, with self-adjoint separated boundary conditions. These are classical problems in computational mathematics which lie on the interface between numerical analysis and spectral theory, with important applications in physics and chemistry, not least in the approximation of energy levels and wave functions of quantum systems. Because of their great importance, many numerical algorithms have been proposed over the years which span a vast and diverse repertoire of techniques. When compared with previous approaches, the principal advantage of the numerical method proposed in this dissertation is that it is accompanied by error bounds which: (i) hold uniformly over the entire eigenvalue range, and, (ii) can attain arbitrary high-order. This dissertation is composed of two parts, aggregated according to the regularity of the potential function. First, in the main part of this thesis, this work considers the truncation, discretization, practical implementation and MATLAB software, of the new approach for the classical setting with continuous and piecewise analytic potentials (Ramos and Iserles, 2015; Ramos, 2015a,b,c). Later, towards the end, this work touches upon an extension of the new ideas that enabled the truncation of the new approach, but instead for the general setting with absolutely integrable potentials (Ramos, 2014).
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34

Mendo, Rodríguez Arnold Ramsey. "Bases para la implementación de la norma peruana de análisis y diseño de edificios con aislación sísmica." Master's thesis, Pontificia Universidad Católica del Perú, 2015. http://tesis.pucp.edu.pe/repositorio/handle/123456789/6817.

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En este trabajo se proponen los requisitos de análisis y diseño de sistemas de aislación sísmica tomando como referencia las normas americanas NEHRP Recommended Seismic Provisions FEMA P-750 (2009) y ASCE/SEI 7-10 (2010), la norma chilena NCh2745-2003 y su actualización del 2013. Esto surge como una necesidad debido al incremento de construcciones con sistemas de aislación sísmica en el Perú, sumado al requisito establecido en la actualización del proyecto de norma E.030 del 2015, para el uso de sistemas de aislación sísmica en la base en establecimientos de salud del Sector Salud del segundo y tercer nivel. Entre las propuestas desarrolladas se encuentran las aceleraciones para el sismo de diseño y sismo máximo probable que permiten construir el espectro de diseño considerando un objetivo de riesgo uniforme de 1% en 50 años, los factores de modificación por incorporación de amortiguamiento (Bd), los factores de amplificación de suelo para periodos estructurales mayores a 1,0 seg y los límites de desplazamiento para las estructuras sobre el sistema de aislación. Además, se propone adoptar la forma del espectro de diseño establecido en las normas americanas NEHRP 2009 ó ACE/SEI 7-10, el cual se construye con aceleraciones para periodos de 0,2 seg y 1,0 seg. Las aceleraciones para estas ordenadas espectrales se obtuvieron del estudio de peligro sísmico de 11 ciudades del Perú agrupadas en 4 zonas según el proyecto de norma E.030 del 2015, amplificadas para considerar de una manera simple y práctica el efecto de la máxima dirección, mediante un factor calculado como la relación entre la ordenada espectral máxima de las dos componentes registradas en un señal sísmica y la aceleración correspondiente a la media geométrica o geoman (√S1.S2). El factor de amplificación que define el sismo máximo probable, fue calculado mediante la relación entre las aceleraciones para un objetivo de riesgo uniforme de 1% en 50 años (convolución de las curvas de peligro sísmico y las curvas de fragilidad) y las aceleraciones para el sismo de diseño (geoman) de las 11 ciudades consideradas en este trabajo, amplificadas para considerar el efecto de máxima dirección. Los factores de modificación amortiguamiento (Bd) fueron calculados en base a la respuesta de desplazamientos de 14 señales sísmicas (dos componentes por señal) ajustando el promedio de la combinación SRSS de las dos componentes al espectro de diseño propuesto, usando el método denominado Mean Spectrum Matching. Los factores de amplificación de sitio se ajustaron a las funciones de amplificación propuestas por Roger D. Borcherdt para el territorio de Estados Unidos. Finalmente, se desarrolla un ejemplo de cálculo de un edificio con aislamiento sísmico comparando su respuesta estructural considerando los requisitos propuestos en este trabajo y los requisitos establecidos en la norma NCh2745-2003 y el ASCE SEI7-10
Tesis
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35

DAGUET-SOUBRANE, GISELE. "Basic fibroblast growth factor (bfgf) dans l'angiogenese oculaire normale, pathologique et experimentalement induire." Paris 6, 1992. http://www.theses.fr/1992PA066102.

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La neovascularisation oculaire pathologique constitue une reponse angiogenique a de nombreuses affections des diverses tuniques oculaires en particulier, la choroide dans le cadre de la degenerescence maculaire liee a l'age (dmla). L'etude de la localisation du facteur de croissance angiogenique bfgf et de ses recepteurs a ete effectuee sur des tissus oculaires normaux et pathologiques de l'homme et de mammiferes. L'existence de bfgf a ete abordee par immunohistochimie, celle des recepteurs de haute et basse affinite par autoradiographie. Bfgf est present chez l'homme dans les neovascularisations de la cornee et de la retine. Nous avons realise un modele experimental d'angiogenese corneenne et choroidienne par perfusion de bfgf, chez le mini-porc. Les neovaisseaux induits ont ete identifies a l'aide d'anticorps specifiques de leurs cellules endotheliales et des differents composants de leur membrane basale. Un anticorps dirige contre ces cellules en proliferation et l'expression de l'oncogene ets-1 etudie par hybridation in situ ont permis d'identifier parmi les cellules endotheliales, celles qui sont neoformees. L'adjonction d'heparine (pour stabiliser bfgf) ou de collagenase (pour favoriser l'infiltration des neovaisseaux) n'a pas modifie de facon notable la reponse angiogenique. Tgfb, perfuse prealablement a bfgf, a agi comme un facteur de proliferation et non de differenciation. La realisation de notre modele a permis de mettre en evidence l'effet angiogenique de bfgf dans la cornee et la choroide. Neanmoins, les neovaisseaux choroidiens n'ont pas traverse la membrane de bruch ce qui est indispensable pour que notre approche constitue un modele parfait de la dmla
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36

Petro, Carrie A. "Eye Tracking Food Cues in Subjects who are Overweight/Obese, Weight Loss Maintainers, and Normal Weight." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1698.

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Adult obesity is associated with increased morbidity and mortality. Increasing success in weight loss maintenance will decrease the prevalence of overweight and obesity, and therefore help control the adverse health effects of excess weight. Much is known about the behavioral characteristics of successful long-term weight loss maintenance, but less is known about the cognitive processes behind weight loss maintenance. The purposes of this study were to (1) identify differences in visual attention to high-energy dense foods between individuals who are normal weight, weight loss maintainers, and overweight/obese in a high-risk (food-buffet) situation; (2) to evaluate differences in food choices from a food buffet between weight status groups; (3) to analyze correlations between food attention and food choice across weight status groups. No significant differences were found between groups with respect to food attention or food choice. Overall, findings from this study may have been limited by methodology, technology, and sample size. Future research is needed to better understand the interaction of cognitive processes and weight loss maintenance.
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37

Chumacero, Sarmiento Cinthia Milagros, and Romero Maritza Maribel Obregón. "Bases para la implementación de las buenas prácticas de manufactura, normas ISO 9001:2000 y aplicación del plan HACCP en la industria cosmética." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2010. https://hdl.handle.net/20.500.12672/16245.

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Publicación a texto completo no autorizada por el autor
Plantea el diseño un modelo de implementación integrando las buenas prácticas de manufactura, Norma ISO 9001, y Plan HACCP para su aplicación en la industria cosmética en ruta a la excelencia en el desempeño de la organización. Para ello fue necesario la definición de términos correspondientes a la Norma ISO 9001, buenas prácticas de manufactura en la industria cosmética y Plan HACCP. Se describe también la secuencia de implementación de cada sistema de gestión de calidad en base a normativas nacionales e internacionales y finalmente se proponen modelos del soporte documentario que el sistema propuesto requiere. El presente estudio se justificó por cuanto podría dar como resultado un sistema más efectivo, se trabajó con las técnicas de manera conjunta y no como sistemas independientes, proporcionando el marco de referencia para la mejora continua de la organización, generando confianza a los miembros de la organización y a sus clientes de su capacidad para elaborar productos que satisfagan los requerimientos de forma coherente.
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38

Corre, Delphine. "Recherches sur les bases juridiques en droit communautaire." Bordeaux 4, 2002. http://www.theses.fr/2002BOR40021.

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Le choix de la base juridique appropriée parmi les dispositions des traités communautaires est une question controversée. Ce choix est défini par la Cour de justice comme un choix pour une politique. A travers l'examen des bases juridiques, on observe le développement des politiques européennes. Nous étudions l'unité ou la diversité des bases juridiques pour la maturation des politiques. Le choix de la base juridique est aussi un choix institutionnel, essentiel pour l'équilibre des pouvoirs. Les institutions sont autorisées à introduire une action en annulation pour défendre leur participation au sein de la procédure législative. La Cour doit aussi donner la solution judiciaire du conflit entre les institutions. Le conflit de la base juridique participe au processus de constitutionnalisation de l'Union. Ce processus s'affirme par la consécration de principes constitutionnels comme les principes de la prééminence du droit, de la séparation des pouvoirs ou de la hiérarchie des normes.
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39

Bouaziz, Tarik. "Spécification et contrôle d’intégrité dans les bases de données objet." Lyon, INSA, 1995. http://www.theses.fr/1995ISAL0008.

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Nous présentons une approche utilisant des règles actives pour spécifier et contrôler l'intégtité d'une base de données objet. Nous proposons une typologie composée des contraintes structurelles, comportementales et explicites. Les contraintes structurelles sont celles inhérentes aux mécanismes d'abstraction. Les contraintes comportementales permettent de contrôler le comportement local et global des objets, elles correspondent aux préconditions et aux postconditions appliquées aux méthodes et aux transactions. Les contraintes explicites correspondent aux propriétés invariantes de l'application. Nous distinguons deux sous-classes de contraintes explicites : les contraintes statiques qui portent sur la cohérence d'un seul état de la base et les contraintes dynamiques qui portent sur les changements d'états permis de la base. L'influence de 1'héritage sur ces types de contraintes d’intégrité a été étudié, ce qui nous a mené à un ensemble de règles d'héritage des contraintes. Les contraintes structurelles sont définies de manière déclarative à l'aide de constructeurs. En revanche, les contraintes comportementales et explicites sont décrites à l'aide de règles actives. Le comportement des contraintes d'intégrité structurelles est connu en fonction des opérations de mise à jour, ce qui permet la génération automatique des règles actives associées. Nous avons développé un modèle de règles actives spécifique au problème de contrôle d'intégrité. Ce modèle est défini par les trois composantes qui sont, le langage de règles actives, les modèles de représentation et d'exécution des règles. Les principes de ce modèle sont mis en œuvre à l'aide d'un prototype de système d'intégrité, nommé ARIS, qui est implanté sous forme de sur-couche au-dessus du SGBD 02
[We present an approach using active rules to specify and control the integrity of an object- oriented databases. We suggest a typology composed of structural, behavioral and explicit constraints. The structural constraints are those inherent to abstraction mechanisms. The behavioral constraints allow to control the local and global behavior of objects, they correspond to preconditions and post conditions applied to methods and transactions. We distinguish two sub-classes of explicit constraints: the static constraints which ensure the consistency of a current state of the database and the dynamic constraints which carry on the changes of authorized states of the database. The int1uence of the inheritance on these integrity constraints was studied, this leads us to propose a set of integrity constraints inheritance rules. The structural constraints are specified in a declarative manner with constructors. However, the behavioral and explicit constraints are specified using active rules. The behavior of structural integrity constraints is known on basis of updates operations, this allows the automatic generation of associated active rules. We developed an active rule mode! adapted to the consistency problem, this model is defined by three components : the active rule language, the knowledge and the execution models. The principles of this model are realized using a prototype of an integrity system, named ARIS, which is implemented with a layered architecture "on top"' of 02 DBMS. ]
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40

Andrade, Luiz Odorico Monteiro de. "GestÃo e Financiamento do Sistema Ãnico de SaÃde à Luz das Normas Operacionais BÃsicas." Universidade Federal do CearÃ, 1997. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10532.

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No presente estudo pretendeu-se analisar o surgimento do Sistema Ãnico de SaÃde (SUS) e o processo de sua regulamentaÃÃo com a publicaÃÃo da Lei OrgÃnica da SaÃde que à composta das Leis 8.080/90 e 8.142/90 e de sua operacionalizaÃÃo com as Normas Operacionais BÃsicas (NOBs), instrumentos de regulamentaÃÃo da situaÃÃo transicional do sistema de saÃde herdado pelo SUS do perÃodo anterior. A primeira NOB analisada foi a 01/91. Esta oficializou o SIA/SUS e SIH/SUS como mecanismos de transferÃncia de recursos, atravÃs de convÃnio, para os Estados e MunicÃpios. Utilizou como parÃmetros a Unidade de Cobertura Ambulatorial - UCA e internamento de 10% da populaÃÃo/ano. Os Estados e MunicÃpios eram considerados para o MinistÃrio da SaÃde como Prestadores de ServiÃos. A segunda NOB analisada foi a NOB-SUS 01/93 que manteve os SIA/SUS e SIH/SUS, porÃm criou trÃs alternativas de enquadramento de gestÃo para Estados e MunicÃpios: Incipiente e parcial (prestadores), e semi-plena (gestores). A terceira NOB analisada foi a NOB-SUS 01/96 que criou a gestÃo Plena da AtenÃÃo BÃsica e a Plena do Sistema Municipal. Esta NOB previu a municipalizaÃÃo das aÃÃes de Epidemiologia e VigilÃncia SanitÃria, criou o Piso Nacional de AÃÃo BÃsica garantindo um valor per capita nacional Ãnico para as aÃÃes bÃsicas de saÃde. Chama-se a atenÃÃo para o pouco cumprimento nestas NOBs dos critÃrios definidos pelo artigo 35 da Lei 8.080/90 para o financiamento das aÃÃes e serviÃos de saÃde.
In the present study aimed to analyze the emergence of the Unified Health System (SUS) and the process of its regulations with the publication of the Health Law which is composed of Laws 8.080/90 and 8.142/90 and its operation with the Operating Standards basic (NOBs), regulatory instruments of transitional situation of the health system inherited from the previous period by SUS. The first NOB analyzed was 01/91. This officially SIA / SUS and SIH / SUS as mechanisms to transfer resources through partnerships, to states and municipalities. Used as parameters to Ambulatory Unit Cover - UCA inpatient and 10% of the population / year. States and municipalities were considered for the Ministry of Health as Service Providers. The second was analyzed NOB NOB-SUS 01/93 that kept the SIA / SUS and SIH / SUS, but created three alternative management framework for States and Municipalities: Incipient and partial (providers), and semi-full (managers) . The third was analyzed NOB NOB-SUS 01/96 that created the management Basic Health Care Full and Complete Municipal System. This NOB predicted the municipalization of Epidemiology and Health Surveillance, created the National Floor Action Basic guaranteeing a single national per capita for basic health. Called attention to the little NOBs fulfilling these criteria defined by Article 35 of Law 8.080/90 to finance actions and health services.
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41

Ghalayini, Ramadan. "Structural modelling of the complex Cenozoic zone of the Levant Basin offshore Lebanon." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066316/document.

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Le bassin de Levant, localisé à l’extrémité la plus orientale de la Méditerranée, se situe à jonction de trois plaques tectoniques majeures (Afrique, Arabie, Eurasie ainsi que la microplaque Anatolienne). Il est bordé à l’Est par la faille du Levant (frontière Arabie/Afrique), qui représente un système transformant de 1000 km de long, reliant le rift dans la Mer Rouge au sud avec la zone de convergence le long du Taurus au nord (frontière Arabie/Eurasie). Son extrémité nord est marquée par la frontière convergente Afrique/Anatolie soulignée par l’arc de Chypre. Le bassin Levantin a enregistré l’interaction entre ces différentes plaques au cours du Cénozoïque et sa bordure Est a été en particulier déformée par la mise en place de la faille du Levant. Cette limite de plaque majeure est marquée au Liban par un relais compressif qui a été actif depuis la fin du Miocène. Jusque récemment, l’absence de données sismiques dans la partie centrale du bassin levantin (offshore Liban) a constitué un handicap important dans la caractérisation de ce basin. Dans ce secteur, la géométrie, cinématique, l’âge des structures tectoniques ne sont pas connus. Plusieurs questions en découlent. Quel est impact de la frontière transformante du Levant sur la structure du bassin? Le bassin a-t-il enregistré d’autres déformations au cours du Cénozoïque ? Quel est l’effet de la structuration ancienne et profonde de la marge sur la déformation actuelle ? Ce travail s’est appuyé sur l’interprétation des données sismiques 2D et 3D de haute qualité dont deux cubes 3D de 4290 m3 et sept lignes 2D de 830 km de long. Cette étude a permis d’identifier les structures tectoniques affectant le secteur offshore Libanais et de caractériser leurs origines. Plusieurs familles de failles tout au long de la marge Est du bassin ont été identifiées et témoigne d’une histoire tectonique méso-cénozoïque longue et complexe. Les structures reconnues sont tout d’abord (1) des failles chevauchantes NNE-SSW actives depuis le début du Tertiaire jusqu’à la fin Miocène, (2) des anticlinaux NNE-SSW formés durant le Miocène supérieur et se localisant sur des structures préexistantes et (3) des failles décrochantes dextres, héritées des structures mésozoïques et réactivées durant le Miocène supérieur. Seules les failles décrochantes dextres montrent des preuves d’une activité actuelle, liée à la transpression au long de la faille du Levant. Ces structures constituent le prolongement vers l’ouest de la frontière de plaque du Levant sous un régime transpressif et une compression NW-SE. Nous mettons en évidence que cette frontière de plaque montre une évolution au cours du Néogène avec une forte décroissance de la composante de raccourcissement à partir du Pliocène. La mise en évidence de jeux plus anciens témoigne d’une structuration profonde E-W de la marge, vraisemblablement héritée des tectoniques mésozoïques. L’impact de cette structuration a été évalué à travers une modélisation analogique. Les résultats démontrent le rôle considérable de cet héritage sur l’évolution du relais compressif de la faille du Levant au Liban, entre autre en localisant la déformation le long de couloirs E-W et en segmentant les structures transpressives NNE-SSW. Ces résultats nous conduisent à interpréter les structures E-W comme majeures et traduisant la prolongation vers l’ouest du bassin mésozoïque des Palmyrides. Nous mettons ici en évidence le rôle majeure d’une marge sur la structure d’une frontière de plaques transformante. Le développement de failles antithétiques (failles dextres dans une frontière transformante senestre), connus dans d’autres frontières de ce type, est ici clairement associé à une anisotropie profonde forçant la localisation de la déformation
The Levant Basin is located at the easternmost Mediterranean at the intersection of three major tectonic plates (Africa, Arabia, Eurasia and the smaller Anatolian microplate). The Levant Fracture System (Arabia-Africa plate boundary) borders the basin to its east and represents a 1000 km long left-lateral transform system linking rifting in the Red Sea with plate convergence along the Taurus Mountains (Arabia-Eurasia plate boundary). The Levant Basin is bordered to the north by the Cyprus Arc (Africa-Eurasia plate boundary). The interaction between these tectonic plates had important consequences on the evolution of the Levant Basin whereby its eastern boundary has been affected by deformation along the Levant Fracture System. This major plate boundary is associated with a restraining bend in Lebanon and has been active since the Late Miocene. Until recent days, the absence of seismic data in the central Levant Basin was an obstacle against characterizing the tectonic setting of the basin. In this area, the geometry, kinematics and the age of the tectonic structures are poorly understood. A focal question thus remains on how the Levant Basin was affected by this adjacent plate boundary. Therefore, what is the impact of the deformation along the Levant Fracture System since the Late Miocene on this basin and how can we assess it? Has the latter been affected by other tectonic regimes prior to the onset of transpression? If so, how would the existing structures influence the style of modern deformation? In this study, high quality 2D and 3D seismic reflection data (with two 4290 m3 3D seismic cubes and seven 830 km long 2D seismic lines) were interpreted allowing identification and timing of the structures in the Levant Basin offshore Lebanon. Several fault families, mapped along the margin, are remnants of a lasting and complex tectonic history since Mesozoic times. These include NNE-SSW striking thrust faults active during the early Tertiary and inactive since the Pliocene; NNE-SSW striking anticlines folded during the Late Miocene and overlying pre-existing structuresd; and ENE-WSW striking dextral strike-slip faults inherited from Mesozoic times and reactivated during the Late Miocene. Only the dextral strike-slip faults show evidence of current activity and are interpreted to be linked to transpression along the Levant Fracture System. They constitute the westward extension of the plate boundary, formed under a transpressif regime and a NW-SE compression. We have showed how this plate boundary has evolved through the Neogene with a decrease in the shortening component during the Pliocene.The identification of pre-existing structures along the eastern Levant margin shed the light on the deep structuration affecting this area, inherited from Mesozoic tectonic events. The impact of these structures was tested through analogue modeling. Results indicated a considerable impact of pre-existing structures on the development of the restraining bend, localizing deformation at the onset of transpression and responsible of segmenting the restraining bend along an ENE direction. These ENE-WSW faults are thus major and are most likely associated with the deformation affecting the Palmyra basin since the Mesozoic, which is thus extending westward to Lebanon. This study has shown the important role of a margin on a strike-slip plate boundary. Namely, the development of antithetic faults (local dextral strike-slip faults in a regional sinistral strike-slip plate boundary) known in other similar plate boundaries is associated with a deep crustal anisotropy localizing the subsequent deformation
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42

Anduri, Sridevi. "Differential protein expression profiles in normal and intersex male smallmouth bass determined using one- and two-dimensional gel electrophoresis a thesis presented to the faculty of the Graduate School, Tennessee Technological University /." Click to access online, 2009. http://proquest.umi.com/pqdweb?index=0&did=2000377671&SrchMode=1&sid=2&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1277817194&clientId=28564.

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43

Aquino, Aquino Jenny Roxana, and Oliva Cecilia Agripina Aguilar. "Guía para establecer las bases de la realización de estudios de biodisponibilidad y bioequivalencia de productos farmacéuticos de administración oral." Universidad Nacional Mayor de San Marcos. Programa Cybertesis PERÚ, 2003. http://www.cybertesis.edu.pe/sisbib/2003/aquino_aj/html/index-frames.html.

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En el presente trabajo se dan las nociones básicas para la realización de estudios de Biodisponibidad y Bioequivalencia. Los estudios de biodisponibilidad permiten conocer la magnitud y velocidad de absorción del principio activo que alcanza la circulación sistémica mientras que los estudios de biodisponiblidad comparativa permiten evaluar la bioequivalencia, de dos medicamentos que contienen el mismo principio activo. Sobre la base del Sistema de Clasificación Biofarmacéutica de los fármacos se puede establecer que para la demostración de la bioequivalencia de los medicamentos comprendidos en la clase 1 y clase 2, se recomiendan los perfiles de disolución; mientras que para la clase 3 y clase 4 se necesita, determinar la bioequivalencia mediante la medición de niveles séricos del fármaco. En el análisis farmacocinético los parámetros de interés son área bajo la curva de los niveles séricos del fármaco (ABC), concentración máxima (Cmax,) y tiempo para alcanzar la máxima concentración (tmax). Teniendo en cuenta los aspectos mencionados anteriormente se elaboró la lista de medicamentos incluidos en el Petitorío Nacional de Medicamentos Esenciales que requieren estudios de bioequivalencia para determinar su intercambiabilidad, encontrándose un total de 61 principios activos. Esta lista se realizó en base a aspectos como: riesgo sanitario, margen tera péutico y características farmacocinéticas del medicamento. Así mismo se elaboró un protocolo básico para la realización de Estudios de Biodisponibilidad y Bioequivalencia, en 1a que se indican las principales etapas para la realización de dichos estudios, también se propone el documento de Consentimiento libre e informado para los voluntarios. Finalmente se diseñó la Unidad para la realización de estudios de biequivalencia, se determinaron los perfiles de los profesionales que conforman el equipo multidisciplinario y se mencionan las diversas instalaciones con las que debe contar la unidad
In the present work are given the basic notions for the execution of Bioavailability and Bioequivalence studies. The bioavailability studies allow to know the magnitude and rate of absortion of the active principle that reaches systemic circulation whereas the studies of comparative bioavailability allow to evaluate the bioequivalence of two medicines with the same active principle. On the base of System of Biopharmaceutical Classification of the drugs it is possible to establish that for demonstration of the bioequivalence of medicines included in the class 1 and class 2, the profiles of dissolution are recommended; whereas for class 3 and class 4 it is needed to determine the bioequivalence by means of measurement of seric levels of drug. Keeping in mind the aspects mentioned previously, it was taken of the list of medicines included in the National Petitory of Essential Medicines those that they would require bioequivalence studies to determine their interchangeability, being found a total of 61 active principles. This list devised in base to aspects as: sanitary risk, therapeutic margin and pharmacokinetic characteristics of the medicine. Likewise devised a basic protocol for the execution of Bioavailability and Bioequivalence studies, in which the main phases for their execution are indicated; also the document of free and reported consent for the volunteers is proposed. Finally a Unit for the execution of bioequivalence studies is proposed, the profiles of the professionals that would conform the multidisciplinary team are proposed and the diverse installations with the ones that should count the Unit are mentioned
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44

Hatayama, Ken. "Excitation of secondary Love and Rayleigh waves in a three-dimensional sedimentary basin evaluated by direct boundary method with normal modes." 京都大学 (Kyoto University), 1997. http://hdl.handle.net/2433/198904.

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45

Weiß, Norman. "Martin H. W. Möllers, Polizei und Grundrechte : Alternatives Grundrechte-Lehrbuch für die Polizei auf rechtswissenschaftlicher und rechtspolitischer Basis [rezensiert von] Norman Weiß." Universität Potsdam, 2006. http://opus.kobv.de/ubp/volltexte/2009/3757/.

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Rezensiertes Werk: Polizei und Grundrechte : Alternatives Grundrechte-Lehrbuch für die Polizei auf rechtswissenschaftlicher und rechtspolitischer Basis / Martin H. W. Möllers Verfasser: Möllers, Martin H. W. - Frankfurt a. M. : Verl. für Polizeiwiss., 2006. - 324 S. : graph. Darst. - (Die Blaue Reihe: Studienbücher für die Polizei) ISBN: 3-935979-77-0
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Genro, Guilherme Saideles. "DEDUÇÃO TRANSCENDENTAL E NORMA FUNDAMENTAL: QUESTÕES DE LEGITIMAÇÃO EM KANT E KELSEN." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/9168.

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This thesis intends to analyse the notions of transcendental deduction and basic norm, presented in the works of Kant and Kelsen, respectively. These concepts are used by the authors quoted as a form to legitimize the objective validity of knowledge, in a general sense in Kant, and specifically the knowledge of Law in Kelsen. The idea to carry out this comparison originated from the analogy used by Kelsen, in his book Pure Theory of Law, between the Kantian categories of understanding, justified through of the transcendental deduction in the Critique of Pure Reason, and the basic norm, where the two notions appear like conditions of the possibility of knowledge. The work is divided into two chapters that deal, respectively, of the transcendental deduction, Objectives, strategies and method of the transcendental deduction of the categories , and of the basic norm, The legal thought of Kelsen and the Kantian s inspiration of the basic norm . Each of them will try to present the assumptions and characteristics of the concepts in question, starting from the objectives that led Kant and Kelsen to formulate them as forms of legitimation of knowledge. Finally, a comparison between the two projects and a discussion about the possibility of a transcendental deduction of the basic norm will be expounded, as well as some conclusions that can be drawn from the work
Este trabalho pretende analisar as noções de dedução transcendental e norma fundamental, apresentadas nas obras de Kant e Kelsen, respectivamente. Tais conceitos são utilizados pelos referidos autores como forma de legitimar a validade objetiva de conhecimento, de maneira geral em Kant, e especificamente o conhecimento do Direito em Kelsen. A idéia de realizar essa comparação surgiu da analogia realizada por Kelsen, em sua obra Teoria Pura do Direito, entre as categorias do entendimento kantianas, justificadas através da dedução transcendental na Crítica da Razão Pura, e a norma fundamental, onde ambas as noções aparecem como condições da possibilidade de conhecimento. O trabalho está dividido em dois capítulos que tratam, respectivamente, da dedução transcendental, Objetivos, estratégias e método da dedução transcendental das categorias , e da norma fundamental, O pensamento jurídico de Kelsen e a inspiração kantiana da norma fundamental . Cada um deles tentará expor os pressupostos e características dos conceitos em questão, a partir dos objetivos que levaram Kant e Kelsen a formulá-los como formas de legitimação de conhecimento. Ao final, será realizada uma comparação entre os dois projetos e uma discussão sobre a possibilidade de uma dedução transcendental da norma fundamental, além da exposição de algumas conclusões que podem ser retiradas do trabalho
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47

Fagundes, Josiane Lara. "O TRABALHO PEDAGÓGICO, AS POLÍTICAS PÚBLICAS DE UNIVERSALIZAÇÃO DA EDUCAÇÃO BÁSICA E O CURSO NORMAL: ENTRE CABOTAGENS, NAUFRÁGIOS E TRAVESSIAS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/7213.

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The present study deals with the Pedagogical Work and Public Policies for Universalization of Basic Education, was carried out from participation in the research line 02-School Practices and Public Policies for Universalization of Basic Education and the Kairos-group of studies and research Work, Public Policy and Education, both linked to the Graduate Program in Education of the Federal University of Santa Maria. Aimed to analyze to what extent the speeches of teachers about their Pedagogical Work at the State Institute of education Olavo Bilac (IEEOB), Santa Maria - RS, highlight possibilities and understandings of Universalization of Basic Education contained in the Public Educational Policies, from 1996. As method and theory of knowledge was based on historical materialism Dialectic research. The study is a qualitative approach and the data were produced through the documentary analysis of the documents of the IEEOB (Pedagogical Proposal, Pedagogical Project in the Normal Course, Pedagogical Project of IEEOB and Normal Course school Regiment) and Public Policies for Universalization of Basic Education (Law of Guidelines and Bases for National Education; Resolution CNE/CEB nº 2 of CNE 1999; Law nº 10,172/2001, PNE 2001; Resolution CNE/CP nº 1/2006; Constitutional Amendment nº 59/2009 and Law nº 13.005/2014, PNE 2014), interviews with 19 professors of IEEOB Normal. In addition to the Interaction Group. We used the technique of Content Analysis to analysis of the data produced. Teachers show how understanding of Universalization of Basic Education the possibility of production of culture and knowledge, in a process of transformation of oneself, of students and of reality in school. Evaluates that Public Educational policies impacted the IEEOB and Normal course, changing, from the times and spaces dedicated to Pedagogical Work, until his accomplishment. It was realized the precarious work of teachers, through the low pay and the intensification of the work. The teachers were away from the ontological dimension of work, recognizing that sometimes turn into robots. The School, the Normal Course and the teachers do not relate directly to the Educational Public Policy changes on IEEOB's educational reality, but realize their ambiguities through this same reality as observed in the Interaction Group. The speeches of teachers about their work showed that the Public Educational Policies generally affected ideologically the Pedagogical Work of the Normal Course of the IEEOB.
O presente estudo trata do Trabalho Pedagógico e das Políticas Públicas de Universalização da Educação Básica, foi realizado a partir da participação na Linha de Pesquisa 02 Práticas Escolares e Políticas Públicas e no Kairós - Grupo de Estudos e Pesquisas sobre Trabalho, Políticas Públicas e Educação, ambos vinculados ao Programa de Pós-Graduação em Educação da Universidade Federal de Santa Maria. Teve por objetivo analisar em que medida os discursos dos professores sobre seu trabalho pedagógico no Instituto Estadual de Educação Olavo Bilac (IEEOB), de Santa Maria RS, evidenciam possibilidades e entendimentos de universalização da Educação Básica contidas nas Políticas Públicas Educacionais, a partir de 1996. Como método e teoria de conhecimento fundamentou-se a investigação no Materialismo Histórico Dialético. O estudo é de abordagem qualitativa e os dados foram produzidos através da análise documental dos Documentos do IEEOB (Proposta Pedagógica, Projeto Pedagógico do Curso Normal, Projeto Pedagógico do IEEOB e Regimento Escolar do Curso Normal) e das Políticas Públicas de Universalização da Educação Básica (Lei de Diretrizes e Bases da Educação Nacional; Resolução CNE/CEB nº 2 de 1999; Lei nº 10.172/2001, PNE 2001; Resolução CNE/CP nº 1/2006; Emenda Constitucional nº 59/2009 e a Lei nº 13.005/2014, PNE 2014), de entrevistas com 19 professores do Curso Normal do IEEOB. Além do Grupo de interlocução. Utilizou-se a técnica de Análise de Conteúdo para análise dos dados produzidos. Os professores evidenciam como entendimento de Universalização da Educação Básica a possibilidade da produção da cultura e do conhecimento, em um processo de transformação de si, dos estudantes e da realidade na Escola. Avalia-se que as políticas públicas educacionais impactaram o IEEOB e Curso Normal, alterando, desde os tempos e os espaços dedicados ao trabalho pedagógico, até sua realização. Percebeu-se a precarização do trabalho dos professores, através da baixa remuneração e da intensificação do trabalho. Os professores foram afastados da dimensão ontológica do trabalho, reconhecendo que, por vezes, transformam-se em autômatos. A Escola, o Curso Normal e os professores não relacionam as Políticas Públicas Educacionais diretamente às mudanças ocorridas na realidade educacional do IEEOB, porém percebem suas ambiguidades através desta mesma realidade como foi constatado no Grupo de interlocução. Os discursos dos professores a respeito de seu trabalho evidenciaram que as Políticas Públicas Educacionais, de modo geral, afetaram ideologicamente o trabalho pedagógico do Curso Normal do IEEOB.
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48

Aguilar, Oliva Cecilia Agripina, and Aquino Jenny Roxana Aquino. "Guía para establecer las bases de la realización de estudios de biodisponibilidad y bioequivalencia de productos farmacéuticos de administración oral." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2003. https://hdl.handle.net/20.500.12672/2330.

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En el presente trabajo se dan las nociones básicas para la realización de estudios de Biodisponibidad y Bioequivalencia. Los estudios de biodisponibilidad permiten conocer la magnitud y velocidad de absorción del principio activo que alcanza la circulación sistémica mientras que los estudios de biodisponiblidad comparativa permiten evaluar la bioequivalencia, de dos medicamentos que contienen el mismo principio activo. Sobre la base del Sistema de Clasificación Biofarmacéutica de los fármacos se puede establecer que para la demostración de la bioequivalencia de los medicamentos comprendidos en la clase 1 y clase 2, se recomiendan los perfiles de disolución; mientras que para la clase 3 y clase 4 se necesita, determinar la bioequivalencia mediante la medición de niveles séricos del fármaco. En el análisis farmacocinético los parámetros de interés son área bajo la curva de los niveles séricos del fármaco (ABC), concentración máxima (Cmax,) y tiempo para alcanzar la máxima concentración (tmax). Teniendo en cuenta los aspectos mencionados anteriormente se elaboró la lista de medicamentos incluidos en el Petitorío Nacional de Medicamentos Esenciales que requieren estudios de bioequivalencia para determinar su intercambiabilidad, encontrándose un total de 61 principios activos. Esta lista se realizó en base a aspectos como: riesgo sanitario, margen tera péutico y características farmacocinéticas del medicamento. Así mismo se elaboró un protocolo básico para la realización de Estudios de Biodisponibilidad y Bioequivalencia, en 1a que se indican las principales etapas para la realización de dichos estudios, también se propone el documento de Consentimiento libre e informado para los voluntarios. Finalmente se diseñó la Unidad para la realización de estudios de biequivalencia, se determinaron los perfiles de los profesionales que conforman el equipo multidisciplinario y se mencionan las diversas instalaciones con las que debe contar la unidad.
In the present work are given the basic notions for the execution of Bioavailability and Bioequivalence studies. The bioavailability studies allow to know the magnitude and rate of absortion of the active principle that reaches systemic circulation whereas the studies of comparative bioavailability allow to evaluate the bioequivalence of two medicines with the same active principle. On the base of System of Biopharmaceutical Classification of the drugs it is possible to establish that for demonstration of the bioequivalence of medicines included in the class 1 and class 2, the profiles of dissolution are recommended; whereas for class 3 and class 4 it is needed to determine the bioequivalence by means of measurement of seric levels of drug. Keeping in mind the aspects mentioned previously, it was taken of the list of medicines included in the National Petitory of Essential Medicines those that they would require bioequivalence studies to determine their interchangeability, being found a total of 61 active principles. This list devised in base to aspects as: sanitary risk, therapeutic margin and pharmacokinetic characteristics of the medicine. Likewise devised a basic protocol for the execution of Bioavailability and Bioequivalence studies, in which the main phases for their execution are indicated; also the document of free and reported consent for the volunteers is proposed. Finally a Unit for the execution of bioequivalence studies is proposed, the profiles of the professionals that would conform the multidisciplinary team are proposed and the diverse installations with the ones that should count the Unit are mentioned.
Tesis
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49

Jouis, Christophe. "Contributions à la conceptualisation et à la Modélisation des connaissances à partir d'une analyse linguistique de textes : réalisation d'un prototype : le système SEEK." Paris, EHESS, 1993. http://www.theses.fr/1993EHES0051.

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Nous presentons un modele linguistique et informatique de comprehension d'unites linguistiques inserees dans leur contexte. Ce modele se presente sous la forme de systemes a base de connaissances d'exploration contextuelle qui recherchent des indices linguistiques dans les textes. Nous montrons qu'il est possible de construire des representations semantiques en n'effectuant qu'une analyse morpho-syntaxique superficielle et en utilisant le contexte d'une unite linguistique examinee. Les informations contextuelles dont nous avons besoin expriment un savoir linguistique sans faire appel a des connaissances sur le monde externe. Nous presentons dans le detail une application informatique de ce modele : seek. Il s'agit d'un outil d'aide a l'analyse et a la description conceptuelle d'un domaine d'expertise (recherche des relations statiques entre entites conceptuelles extraites de compte-rendus d'expertise). Cette derniere application est integree dans un atelier de genie cognitif associe a metodac, une methodologie d'acquisition et de modelisation des connaissances
We present a linguistic and computer model the aim of which is the understanding of linguistic items inserted in their context. This model is constituted by knowledge based systems of contextual exploration which consists in seeking linguistic clues in texts. It is shown that nothing else than a basic morpho-syntactical analysis and the use of the context of an examined linguistic item is required to build semantic representations. These contextual data express a knowledge of the language without using any other knowledge of the world. We present in details a program based on this model : seek. It is a help tool for knowledge extraction forme texts in natural language. This latter has been integrated in a workshop of cognitive engineering associated to a methodology of knowledge acquisition and modelling called metodac
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Marchi, Jerusa. "Opérateurs syntaxiques pour le changement de croyances basés sur la représentation en formes normales premières." Toulouse 1, 2006. http://www.theses.fr/2006TOU10044.

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L'étude du changement des croyances consiste en l'étude de méthodes permettant l'incorporation d'une information nouvelle à un ensemble initial de croyances. Ces méthodes ont pour objectifs principaux de s'assurer que la base obtenue soit cohérente et que la base originale ait été soumise à un nombre minimal de changements. Formellement, la notion de changement minimal est décrit par un critère de proximité entre des bases de croyances représenté par une distance entre les modèles des bases. Ce critère est utilisé par les méthodes de révision des croyances et de mise-à-jour des croyances. Ce travail présente une version syntaxique des opérateurs de Dalal, Forbus et Winslett pour le changement des croyances. Les opérateurs proposés nécessitent une représentation des bases de croyances sous la forme d'impliquants premiers et d'impliqués premiers. Nous montrons que les versions syntaxiques proposés sont strictement équivalentes à ces opérateurs usuels. Le travail propose aussi deux nouveaux opérateurs syntaxiques de changement de croyances basés sur une définition différente de la notion de changement minimal. Le nouveau critère de minimalité proposé est défini par la relation "holographique" entre les littéraux apparaissant dans une forme première et leur usage dans l'autre forme première, c'est-à-dire dans les clauses et termes. Cette nouvelle aproche permet de créer un contexte pour les libéraux qui ensuite pose en de nouveaux termes le changement de croyances. Nous montrons que cette nouvelle notio de minimalité produit des changements plus pertinents et plus minimaux dans les bases de croyances que la notion usuelle de distance minimale
Studying Belief change mainly consists of the elaboration of methods which allow to incorporate new information in a belief set. The aim of these methods is to ensure that the resulting belief is consistent and that the initial belief set has changed in a minimal way. Formally, the notion of minimal change is represented by a closeness criterion based on distance between the models of the belief sets. This criterion is widely use in the Belief Revision and Belief Update areas. In this work we present a syntactic version of the Dalal, Winslett and Forbus beleif change operators. The proposed operators are based on a specific representation of belief set. Namely beliefs has to be represented using Prime Implicants and Prime Implicates notation. In this work, we show that we can express Dalal, Winslett and Forbus methods in a syntactic way. In this work, we also proposed two new syntactic belief change operators which are based on a new definition of minimal change. This new notion of minimal change is based on of an "holographic"relation between the two representations : the prime implicants and the prime implicates. We associate to each literal that appear in the prime implicates the set of prime implicated in which they also appear. This representation allows to rephrase the notion of minimal change in terms of propositional symbols and their use. We show that this new minimal unit of change leads to more relevant change in belief sets than the Dalal distance
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