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Journal articles on the topic 'Normas CIRSOC 301'

Author: Grafiati

Published: 17 September 2021

Last updated: 30 July 2025

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1

Bell, Ronny A., Daniel J. Zaccaro, Lynne E. Wagenknecht, and Elizabeth J. Mayer-Davis. "Ethnicity, CVD Risk Factor Clustering and the Progression of Microvascular Disease: The Insulin Resistance and Atherosclerosis Study." Circulation 103, suppl_1 (2001): 1356–57. http://dx.doi.org/10.1161/circ.103.suppl_1.9998-31.

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P31 Ethnic disparities in cardiovascular disease (CVD) and end-stage renal disease exist in the US, with African Americans (AAs) and Hispanic Americans (HAs) being at greater risk compared to non-Hispanic whites (NHWs). This maybe related to variations in individual and/or clusters of CVD risk factors across ethnic groups. We have previously shown ethnic differences in cross-sectional analyses from the Insulin Resistance and Atherosclerosis Study (IRAS) data in the effect of CVD risk factor clustering, with AAs being more greatly affected for nephropathy risk, and NHWs being more affected for

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Lindqwister, Alexander L., Samuel B. Klein, Colin Raelson, Karen L. Moodie, Kevin M. Stanko, and Norman A. Paradis. "Abstract 301: Aortic and Central Venous Pressure Wave Synchronization in Pseudo-Pulseless Electrical Activity." Circulation 142, Suppl_4 (2020). http://dx.doi.org/10.1161/circ.142.suppl_4.301.

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Introduction: Pseudo-Pulseless Electrical Activity (p-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. p-PEA may constitute up to 40% of reported cases of cardiac arrest and its etiologies and physiology are distinctly different from ventricular fibrillation or even true-PEA. In the normal physiologic state, there is an expected delay between the central venous (CV) and aortic (Ao) pressure waveforms corresponding to atrial kick and ventricular systole, respectively. We studied this relationship in h

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Skåre, Christiane, Britt Nakstad, Jo Kramer-Johansen, et al. "Abstract 303: Frequency of Newborn Resuscitation and Stabilization in Three Normal-Risk Delivery Units in Norway." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a303.

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Introduction: Most newborn infants transition from intra- to extrauterine life without interventions; yet neonatal morbidity remains a significant health problem in both resource rich and resource poor health care systems. Although advanced resuscitation of newborn infants with chest compressions, intravenous drugs, and fluids is relatively rare, there are limited data on the frequency of neonatal stabilization and resuscitation measures in normal-risk delivery units. METHODS: Prospective, observational study conducted in the delivery units in three hospitals in Norway. All newborn infants ass

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Lin, Ying, Qifan Yang, Xiaoping Lin, et al. "Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.14239.

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Background: Extracellular matrix (ECM) is involved in aortic valve development and aortic valve anomaly. ADAMTS gene mediated ECM dysfunction was reported to be related to aortic valve diseases. Hypothesis: The ADAMTS gene family members can contribute to aortic valve diseases. Methods: Morpholino based adamts gene-targeted phenotype-screening of outflow tract anomaly in zebrafish and the 19 ADAMTS family gene-targeted exon sequencing on a cohort BAV patients (304 BAV and 301 normal controls) were performed. Accordingly, both specific genetic tracing and different gene modified mouse models we

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Kojima, Sunao, Tomohiro Sakamoto, Akira Kitagawa, and Hisao Ogawa. "Abstract 3763: Standard-dose Statin Therapy Demonstrates Additional Effects In Diabetic Patients With Normal Cholesterol Levels." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_855-c.

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Background: Randomized trials established statins as an agent for prevention of coronary heart disease (CHD). We assessed the hypothesis that standard-dose statin therapy had a beneficial effect in diabetic CHD patients with normal cholesterol levels. Methods and Results: To evaluate the effect of statins after percutaneous coronary intervention (PCI) on subsequent cardiovascular events, a prospective, randomized, open, blinded-endpoint trial conducted from 2002 to 2004 at 55 hospitals in Japan. A total of 1,016 patients (301 patients with diabetes mellitus [DM] and 715 non-DM patients) whose

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Chang, Wei-Tien, Ping-Hsun Yu, Yen-Wen Wu, et al. "Abstract 301: Tc-99m ECD SPECT Brain Perfusion as a Novel Indicator Predicting Neurological Prognosis in Patients Resuscitated From Cardiac Arrest." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a301.

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Background: To date there are limited prognostic indicators that well predict the neurological outcomes in patients resuscitated from cardiac arrest. 99m Tc-ethylcysteinate dimer (ECD) brain perfusion scan has been shown to implicate the viability of neurons. We therefore investigate the role of this novel indicator in predicting post-resuscitation neurological prognoses. Methods: Post-cardiac arrest patients who remained unconsciousness after CPR were prospectively enrolled from Jan. 2010 to May 2013. Brain perfusion scan with 99m Tc ECD SPECT were performed within 3-10 days post-CPR. All ima

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Sanatkhani, Soroosh, Sotirios Nedios, Sandeep K. Jain, Samir Saba, Prahlad G. Menon, and Sanjeev G. Shroff. "Abstract 16439: Is Pulmonary Venous Flow Pulsatility a Critical Determinant of Left Atrial Appendage Blood Stasis Risk?" Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.16439.

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Introduction: Atrial fibrillation (AF) is the most common arrhythmia that leads to thrombus formation, most commonly in the left atrial appendage (LAA), and a resultant five-fold increase in the risk of ischemic stroke. The current standard of stratifying stroke risk, based on the CHA 2 DS 2 -VASc score, does not consider subject-specific LAA hemodynamics and blood stasis risk. We have developed a methodology for computing mean residence time of blood-borne particles in the LAA ( t m ), an index of LAA blood stasis, using 3D left atrial (LA) and LAA geometries and pulmonary venous (PV) inlet b

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Kuebler, Joseph D., Meena Nathan, Gerald Marx, Steven Colan, and David M. Harrild. "Abstract 16855: Left Ventricular Volumes, Stress, and Strain in Normal Children and Young Adults Measured by 3-Dimensional Echocardiography." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.16855.

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Background: 3D echocardiography (3DE) is increasingly being used clinically to calculate ventricular volumes and function. Normal pediatric values of 3D LV volumes and strain are not well established; moreover, there are no reports of the stress-strain relationship (an index of contractility) based upon 3D technology in this cohort. Methods: 3D LV datasets were obtained as part of routine echocardiographic examinations in eligible pediatric patients (≤ 21 years of age) between January 2014 and March 2015. Included patients had structurally normal hearts. Exclusion criteria included non-cardiac

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Spurr, Rebecca, Jeffrey Conwell, Luciana T. Young, Aarti Bhat, Mark Lewin, and Bhawna Arya. "Abstract 17104: Utility of Screening Fetal Echocardiogram Following Normal Anatomy Ultrasound for In Vitro Fertilization Pregnancies." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.17104.

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Introduction: In-vitro fertilization (IVF) is associated with a higher incidence of congenital heart disease (CHD), resulting in universal screening fetal echocardiograms (F-echo) even when obstetric scan (OB-scan), including cardiac structures is normal. Recent studies suggest that when OB-scan is normal, F-echo may add little benefit and increases cost and anxiety. We aim to determine the utility of screening F-echo in IVF pregnancies with normal cardiac anatomy on prior OB-scan. Methods: We conducted a retrospective chart review of IVF pregnancies referred for F-echo at the Seattle Children

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Kanneganti, Radha, Zeina Dardari, Roger S. Blumenthal, et al. "Abstract 13711: Coronary Artery Calcium, Ankle-brachial Index, High Sensitivity C-reactive Protein, and a Family History of Coronary Artery Disease as Predictors of Incident Cardiovascular Events at Different Stages of Hypertension: The Multi-ethnic Study of Atherosclerosis." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.13711.

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Background: Coronary artery calcium (CAC), ankle-brachial index (ABI), high-sensitivity CRP (hsCRP), and family history (FHx) of coronary artery disease (CAD) are used as complementary aids in cardiac risk stratification. The 2017 ACC/AHA hypertension guideline’s new Stage I hypertension group has created uncertainty regarding intensity of blood pressure (BP) treatment in this group. We evaluated the comparative utility of CAC, ABI, hsCRP and FHx CAD as risk predictors of cardiovascular (CVD) events within different BP strata. Methods: The MESA cohort was followed for a median of 13 years with

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Zamirpour, Siavash, John Depaolo, James Brundage, Scott Damrauer, and James Pirruccello. "Abstract 4124655: Multi-trait analysis identifies 307 genomic loci for thoracic aortic diameter and disease." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4124655.

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Introduction: Thoracic aortic aneurysm and dissection (TAAD) is a morbid cardiovascular disease with 21 known common-variant genomic risk loci. Aneurysm represents an extreme of diameter, so we sought to jointly analyze TAAD and aortic diameter to enhance discovery power. Methods: Genome-wide association studies (GWAS) were performed for UK Biobank MRI-derived aortic diameter measured at the aortic root (N=62,919), ascending aorta (N=61,156), and descending aorta (N=62,412). Separately, TAAD GWAS summary statistics from UKB (1,076 cases, 416,263 controls), FinnGen (3,880 cases, 381,977 control

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Masson, Serge, Luciano Moretti, Ospedale Mazzoni, et al. "Abstract 4331: Elevated Albumin Excretion is an Independent Risk Factor in Patients with Chronic Heart Failure. Data from the GISSI-Heart Failure Trial." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_866.

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Elevated albuminuria, a marker of endothelial renal damage, is a risk factor for cardiovascular events in the general population and in patients with diabetes or hypertension. We report here on its association with mortality in a large population of patients with chronic HF. Albuminuria (albumin/creatinine concentration ratio in a morning spot sample, UACR) was determined in 2131 patients with chronic HF enrolled in 77 centers participating to the GISSI-HF trial. Patients were divided according to normal (UACR <30 mg/g) and abnormal urinary excretion of albumin (≥30 mg/g). Association betwe

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Ye, Jian, Guangping Dai, Lawrence N. Ryner, et al. "Unilateral Antegrade Cerebral Perfusion Through the Right Axillary Artery Provides Uniform Flow Distribution to Both Hemispheres of the Brain." Circulation 100, suppl_2 (1999). http://dx.doi.org/10.1161/circ.100.suppl_2.ii-309.

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Background —Bilateral antegrade cerebral perfusion (ACP) has decreased in popularity over the past decade because of its complexity and the risk of cerebral embolism. We used magnetic resonance (MR) perfusion imaging to assess flow distribution in both hemispheres of the brain during unilateral ACP through the right carotid artery via a cannula placed in the right axillary artery in conjunction with hypothermic circulatory arrest. Methods and Results —Twelve pigs were randomly exposed to 120 minutes of either bilateral ACP through both carotid arteries (n=6) or unilateral ACP through the right

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Mathuria, Nilesh, Jianwen Wang, April L. Gilbert, et al. "Abstract 3071: Reversible Transmural Electrical Dyssynchrony in Pacing-Induced Congestive Heart Failure." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_688-c.

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Introduction: Inter and Intra-ventricular dyssynchrony can develop during congestive heart failure (CHF). We investigated transmural electrical conduction properties within the LV wall during CHF and subsequent recovery. Methods: Biventricular pacemakers were implanted in 8 normal mongrel dogs (mean weight: 38 kg), and continuous RV pacing (230 –250 bpm) was initiated to induce CHF. Echocardiography, catheterization, and LV myocardial biopsy were performed biweekly while pacing was temporarily stopped. At each catheterization, an intracardiac electrode-catheter was placed at the LV endocardium

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Kany, Shinwan, Joel Rämö, Cody Hou, et al. "Abstract 14595: Leveraging Deep Learning to Elucidate Subclinical Aortic Stenosis Risk." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.14595.

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Background and Aims: Aortic stenosis (AS) is associated with a high global burden of morbidity. Current guidelines do not fully define normal aortic valve (AV) function or mild AS. We aimed to study normal variation in AV function and address current gaps in knowledge. Methods: We developed a deep learning model to study velocity-encoded magnetic resonance imaging (MRI) in 47,223 UK Biobank participants. We calculated aortic valve area (AVA), peak velocity (PV), and mean gradient (MG). Results: In healthy individuals, we found an annual decrement of 0.03 cm2 in AVA. Normal variation in AV func

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Aminorroaya, Arya, Lovedeep Dhingra, Aline Pedroso Camargos, Evangelos Oikonomou, and Rohan Khera. "Abstract 4146678: Artificial Intelligence-enhanced Interpretation of Single-lead Electrocardiogram in Normal Sinus Rhythm to Detect and Predict Atrial Fibrillation and Flutter." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4146678.

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Background: Portable ECG devices can help identify symptomatic atrial fibrillation/flutter (AF) episodes outside healthcare settings. However, most individuals remain undiagnosed due to the transient and often asymptomatic nature of AF. Here, we developed an AI-ECG model to detect concomitant paroxysmal AF and predict its future risk using lead I ECG recordings in normal sinus rhythm (NSR), with special adaptation for noisy acquisition on portable devices. Methods: The model was developed using 1.6 million ECGs at Yale (2000-2015). ECGs in NSR associated with an ECG with AF rhythm from 30 days

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Belmadani, Souad, Darwin Prockop, and William Chilian. "Abstract 302: The Importance of Adhesion in Multipotent Stromal Cell-Induced Coronary Collateral Growth/Arteriogenesis." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_42.

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Because of the potential of stem cells and stromal cells to differentiate into vascular cells, their most salubrious role in the treatment of patients with ischemic heart disease may be as prophylactic agents preventing infarction by stimulating coronary collateral growth (CCG). Therefore, we determined if multipotent stromal cells (MSCs: CD59+, CD90+) would amplify CCG in a rat model of ischemia, but without infarction. Rats were instrumented with a pneumatic snare around the left anterior descending artery and subjected to repetitive ischemia (RI: 24 40 sec occlusions/day for 10 days) to sti

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Basavarajaiah, Sandeep, Lorna Carby, Arash Yavari, et al. "Abstract 3001: Assessment Of Ethnic Differences In The Left Ventricular Remodelling In Elite Athletes." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_671-b.

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Objectives: The upper limits of physiologic increase in the left ventricular (LV) dimensions for the purposes of differentiation from cardiomyopathies are well established in Caucasian athletes. However, there are few data regarding the physiologic LV remodelling in black athletes (BA) in whom deaths from cardiomyopathies are more prevalent. Methods: Between 2005 and 2006, 200 asymptomatic and normotensive black (African/AfroCaribbean) male athletes (mean age: 20.5 ± 5.80; range 14 –35 years and a mean BSA: 1.94 ± 0.16 m 2 ; range1.36 –2.29) underwent 12-lead EKG and 2-D echocardiography. The

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Nguyen, Vi, Chao Gao, Marcelo L. Hochman, et al. "Abstract 14173: Generation and Characterization of Clinically Relevant Disease Models for Port Wine Birthmark Using Induced Pluripotent Stem Cells." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.14173.

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Introduction: Port Wine Birthmark (PWB) is a congenital vascular malformation with a progressive development. The current treatments for PWB are Pulse Dye Laser and Photodynamic Laser Treatment. However, the efficacy of blanching the birthmark is inadequate, and the reoccurrence after treatment is a major clinical barrier. Developing clinically relevant disease models that can be used for mechanistic and therapeutic development studies is the critical unmet need. Induced pluripotent stem cell (iPSC) is a powerful tool in different disease models and drug discovery. Besides, iPSC-derived cells

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Kan, Xiaoxin, Xun Yuan, M. Yousuf Salmasi, et al. "Abstract 10478: Comprehensive Mechanical Modelling of Thoracic Endovascular Aortic Repair in Type A Aortic Dissection." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10478.

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Background: Thoracic endovascular aortic repair (TEVAR) in selected proximal (Stanford type A) aortic dissection (TAAD) cases has been reported, however, the limitation and criteria for TEVAR applied in TAAD remain controversial. Virtual stent-graft (SG) deployment simulation based on the finite element method is an emerging tool that allows TEVAR to be reproduced for detailed analysis of biomechanical interaction between native vessel wall and SG device. Methods: A TAAD patient underwent an unsuccessful TEVAR followed by salvage open surgical repair. Pre-TEVAR CT angiogram was used to establi

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McAuley, Paul A., Haiying Chen, Duck-chul Lee, Enrique G. Artero, David A. Bluemke, and Greg L. Burke. "Abstract P258: Physical Activity Attenuates the Impact of Obesity on Cardiometabolic Risk: The Multi-Ethnic Study of Atherosclerosis (MESA)." Circulation 125, suppl_10 (2012). http://dx.doi.org/10.1161/circ.125.suppl_10.ap258.

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Background: The impact of higher physical activity on the relationship between adiposity and cardiometabolic risk is not completely understood. Methods: The cross-sectional association between body mass index (BMI) and cardiometabolic risk stratified by intentional physical activity was examined in 6814 Multi-Ethnic Study of Atherosclerosis participants, during 2000-2002. Self-reported physical activity in the lowest quartile (0-105 MET-minutes/wk) was categorized as inactive with the upper three quartiles (123-37,260 MET-minutes/wk) categorized as active. The association of BMI categories of

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McLeod, Jennifer, Barry E. Hurwitz, Daniela Sotres-Alvarez, et al. "Abstract P092: Longitudinal Impact Of Blood Pressure On Left Ventricular Geometry In The Hispanic Community Health Study/Study Of Latinos: Echocardiographic Study Of Latinos (Echo-SOL) Ancillary Study." Circulation 143, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.143.suppl_1.p092.

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Introduction: Abnormal left ventricular geometry (LVG) is an independent predictor of cardiovascular mortality. We assessed the longitudinal transitions of LVG among Hispanic/Latino adults. Methods: Echo-SOL provided serial 2D echocardiograms of Hispanic adults. Each subject was identified as hypertensive or normotensive and categorized into four LVG patterns: normal, concentric remodeling (CR), concentric hypertrophy (CH), or eccentric hypertrophy (EH). Hypertensive adults were stratified on whether they maintained blood pressure (BP) control (<140/90mmHg) by visit 2. The normotensive adul

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Hamatani, Yasuhiro, Moritake Iguchi, Kimihito Minami, et al. "Abstract 10446: Prognostic Significance of Left Ventricular Ejection Fraction in Atrial Fibrillation Patients Without Pre-Existing Heart Failure." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.10446.

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Introduction: Atrial fibrillation (AF) increases the risk of heart failure (HF). However, little focus has been placed on the prevention of HF in patients with AF. Hypothesis: Left ventricular ejection fraction (LVEF) is an established echocardiographic parameters in patients with HF. We hypothesized that LVEF is a useful predictor for incident HF in AF patients even without HF. Methods: The Fushimi AF Registry is a community-based prospective survey of AF patients in Fushimi-ku, Kyoto, Japan. After excluding patients without pre-existing HF (defined as having one of the following; prior HF ho

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Egbe, Alexander, and Carole Warnes. "Abstract 12752: Left Ventricular Dysfunction After Aortic Valve Replacement in Mixed Aortic Valve Disease: Are We Operating Too Late?" Circulation 134, suppl_1 (2016). http://dx.doi.org/10.1161/circ.134.suppl_1.12752.

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Introduction: The fate of the left ventricle (LV) after aortic valve replacement (AVR) in mixed aortic valve disease (MAVD) is unknown. Hypothesis/objectives: To determine prevalence and predictors of early and late left ventricular dysfunction (LVD) defined as EF <50% at 1 and 5 years post-AVR. Methods: Patients with moderate-severe MAVD, ejection fraction ≥50%, no documented coronary artery disease, and a minimum of 2-year follow-up after AVR were identified. Moderate-severe MAVD was defined as a combination of ≥moderate aortic stenosis and ≥moderate aortic regurgitation. EF was assessed

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Harris, Chelsea S., David Amar, Nicole E. Howard, et al. "Abstract 14707: Electrocardiographic Abnormalities Are Common in DCM Patients’ Family Members With Early Manifestations of DCM." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.14707.

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Introduction: Imaging and 12-lead electrocardiogram (ECG) are recommended to screen individuals at risk of dilated cardiomyopathy (DCM). Few studies have examined the yield of ECG testing in these individuals. We hypothesized that ECG abnormalities are more frequent in DCM patients’ family members with early imaging manifestations of DCM than in those without. Methods: The multisite DCM Precision Medicine Study collected contemporaneous imaging and ECG in 1226 First Degree Relatives (FDRs) of DCM patients aged ≥ 18 years between 06/2016 and 04/2021. Imaging results were used to classify partic

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Supariwala, Azhar A., Waddy Gonzales, Matthew Pierce, et al. "Abstract 18911: Prognosis of Latent Systolic Dysfunction in Patients Referred for Stress Echocardiography With Normal LV Ejection Fraction." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a18911.

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Background: Tissue Doppler imaging can assess latent systolic function. The prognostic impact of latent systolic dysfunction in patients with normal ejection fraction is limited. Methods: We measured the left ventricular septal S wave velocity (Sm) at rest in 908 patients, mean age 58 ±14 years, 40% males who were referred for stress echocardiography with normal left ventricular ejection fraction (>55%). Results: There were 42 (5%) deaths during the mean follow-up of 3.1 ± 0.6 years. Only 44 (6%) had ischemia on stress echocardiogram. There were significant high correlations observed betwee

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Tawfiq, Reema, Nicholas Boddicker, Juan Quintero Martinez, et al. "Abstract 10607: Evaluating Diastolic Function by Echocardiography in a Prospective Cohort of Patients with Hodgkin (HL) and Non-Hodgkin Lymphoma (NHL) Who Received Anthracycline-Based Chemotherapy." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10607.

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Introduction: Anthracyclines are a first-line chemotherapeutic agent used in the treatment of lymphoma. Myocardial injury can occur with cumulative doses of 250 to 350 mg/m 2 . Echocardiography is the imaging modality for identifying cardiac dysfunction; however, identifying diastolic changes in patients who received anthracyclines is not well represented in the literature. Variables used to identify diastolic dysfunction include lateral e’, medial e’, mitral E velocity, mitral A velocity, E/A, E/e’, and left atrial volume index (LAVI). This study aims to identify if diastolic abnormalities de

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Kuwabara, Yukimitsu, Kohtaro Abe, Mayumi Hirano, Yoshitaka Hirooka, Kenji Sunagawa, and Katsuya Hirano. "Abstract 15241: Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.15241.

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Introduction: Pulmonary hypertension (PH) is characterized by thrombus formation, vasoconstriction and vascular remodeling. The normal pulmonary artery, in contrast to the systemic artery, has a unique property to contract in response to thrombin via thrombin receptor Proteinase-activated receptor 1 (PAR1). Hypothesis: We hypothesized that PAR1 plays a key role in the pathogenesis and pathophysiology in PH and examined the therapeutic effects of PAR1 antagonist on PH. Methods and Results: Adult male SD rats developed PH after a single subcutaneous injection of 60 mg/kg monocrotaline (MCT) on d

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Silvestre, Odilson M., Alexandra Gonçalves, Wilson Nadruz, et al. "Abstract 18440: Low Ferritin Levels are Associated With Increased Risk of Heart Failure - The Atherosclerosis Risk in Communities Study." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.18440.

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Introduction: While severe iron overload has been associated with cardiac damage, iron deficiency is related to worse outcomes in subjects with heart failure (HF).This study investigated the relationship between ferritin, a marker of iron status, and the incidence of HF in a general population based sample. Methods: We examined 1,063 participants from the Atherosclerosis Risk in Communities (ARIC) study, mean age 52±5 years, 62% women, free of heart failure, in whom ferritin serum levels were measured at baseline (1987-1989). The participants were categorized in low (200 ng/mL in women and &gt

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Brunton, Nicole M., Allison Dart, Meghan Azad, and Jonathan M. McGavock. "Abstract 41: The Effect Of Maternal Weight On Offspring Blood Pressure At 18 Years Of Age: A Causal Natural-effects Mediation Analysis." Circulation 141, Suppl_1 (2020). http://dx.doi.org/10.1161/circ.141.suppl_1.41.

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Objectives: Examine the relationship between maternal pre-pregnancy body mass index (BMI) and offspring systolic blood pressure (SBP) at 18 yrs old. Methods: We performed multivariate regression and causal mediation analysis within 3700 mother - offspring pairs from a prospective birth cohort. The main exposure was maternal pre-pregnancy BMI categorized as healthy weight, overweight, or obese according to international criteria. The main outcomes were high-normal BP and hypertension defined as SBP between the 90-95 th centile and >95 th centile for height and sex at 18 years, respectively,

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Sakamoto, Hiroaki, Shonosuke Matsushita, Kazuyuki Hyodo, Chiho Tokunaga, Fujio Sato, and Yuji Hiramatsu. "Abstract 12369: Synchrotron Radiation Coronary Microangiography Could Confirm Induction of Coronary Vasoconstriction by Cold Exposure in the Diabetic Rat." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.12369.

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Background: Previous reports have suggested that sympathetic nerve stimulation by cold exposure induces coronary vasoconstriction in diabetes, but this has not been directly confirmed. The purpose of this study was to confirm, in the in vivo diabetic rat, that coronary vasoconstriction is induced by cold exposure. Conventional coronary angiography cannot visualize small arteries of less than 300 μm in diameter, such as the rat coronary artery. We have developed a system of synchrotron radiation coronary microangiography (SRCA) in the in vivo rat. SRCA can visualize vessels as small as 50 μm in

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Wohlfahrt, Peter, Slavomir Rokosny, Peter Balaz, Daniel Palous, and Vojtech Melenovsky. "Abstract 16305: Cardiac and Circulatory Adaptation to Volume Overload: The Impact of Reduction of High-flow Arterio-venous Fistula." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.16305.

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Introduction: Heart failure is present in one out of three patients on hemodialysis and is the leading cause of death. Because increased blood flow through the arteriovenous fistula (AVF) leads to volume overload potentially causing high-output heart failure, reduction (e.g. aneurysmorrhaphy) or occlusion of a hyperfunctional AVF (hAVF) is commonly performed. However, there are no clear indications for these procedures. The aim of this study was to evaluate the impact of aneurysmorrhaphy on hemodynamics and cardiac structure in patients with hAVF. Methods: Thirty patients (age 52 ± 12 years, 7

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Rallidis, Loukianos, Christoforos Komborozos, Argyri Gialeraki, et al. "Abstract 3457: Methylenetetrahydrofolate Reductase Gene Polymorphism C677T And The Risk Of Premature Myocardial Infarction With “Normal” Coronary Arteries." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_781-d.

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Purpose: the pathogenetic mechanism of acute myocardial infarction (AMI) in young patients remains unknown. We explored the impact of homocysteine and its main genetic modulator Table 2 methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in patients who sustained AMI under the age of 36 years. Methods: we recruited 136 consecutive patients who had survived their first AMI before the age of 36 years (mean age=32 ± 3.1 years, range 23–35 years, 121 men). Blood was taken for lipids and homocysteine levels within 12 hours from admission. The MTHFR C677T polymorphism was also determined

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Vella, Chantal A., Ximena Burgos-Monzon, and Carla J. Ellis. "Abstract P174: Increased Cardiovascular Disease Risk Factors in Young Hispanic Women at the High-end of Normal-weight Body Mass Index." Circulation 129, suppl_1 (2014). http://dx.doi.org/10.1161/circ.129.suppl_1.p174.

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BMI is often used to assess risk of cardiovascular disease (CVD); however, current BMI cutpoints may not be accurate for all ethnicities. Given the high prevalence of obesity and type 2 diabetes in Hispanics, it is important to examine whether current BMI cutpoints accurately identify those at healthy weight and those at risk. We examined whether there was a difference in CVD risk factors within the normal-weight BMI category in young, Hispanic women. We hypothesized that women in the highest tertile of normal-weight would have significantly more CVD risk factors than those in the lowest terti

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Chan, Wing Sze, Ching Hon Luk, and Hung Fat Tse. "Abstract 3091: Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain In Outpatient Clinic By Adenosine Stress Magnetic Resonance." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_693.

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Background: This study was designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) in low to moderate total number cardiac risk factor (TLCRF) patients presenting with chest pain in outpatient clinic. We hypothesized that adenosine CMR has a high negative predictive value in development of CAD or future adverse cardiac events. Methods: Adenosine stress CMR was performed on 315 pts who presented initially to outpatient clinics with chest pain. Ten patients confirmed to have previous myocardial infarction defined by delay CMR were excluded. Three patients were ex

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Steinberg, Benjamin A., Gregg C. Fonarow, Adrian F. Hernandez, Wenqin Pan, Eric D. Peterson, and Christopher P. Cannon. "Abstract 4206: Invasive Treatments for Obese Patients with CAD: An Explanation for the “Obesity Paradox”? Analysis of 130,139 Hospitalizations in Get With The Guidelines." Circulation 114, suppl_18 (2006). http://dx.doi.org/10.1161/circ.114.suppl_18.ii_908.

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BACKGROUND : Obesity is a well documented risk factor for cardiovascular disease and long-term mortality, yet a previous analysis of the Get With The Guidelines (GWTG) database revealed a paradoxically lower short-term mortality rates in patients with coronary artery disease (CAD). We hypothesized that this surprising trend may be the result of more aggressive management of such patients. METHODS : The GWTG database was analyzed for CAD hospitalizations from 1/00 to 12/05 with documented height and weight. Patients were divided into BMI (kg/m 2 ) categories: underweight (< 18.5), healthy we

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Clavel, Marie-Annick, Christophe Tribouilloy, Joseph Malouf, et al. "Abstract 11602: Impact of Pre-Operative Type-B Natriuretic Peptide Level on Survival After Aortic Valve Replacement for Aortic Stenosis." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.11602.

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Introduction: Levels of type-B natriuretic peptide (BNP) adjusted for age and sex are a powerful predictor of mortality after the diagnosis of aortic stenosis (AS). Objective: To assess whether BNP activation (compared to normal values) affects mortality after aortic valve replacement (AVR). Methods: In 494 patients with AS, plasma level of BNP was measured pre-operatively at the time of Doppler-Echocardiography. BNP was normalized as BNPratio (BNP measured/BNP maximum normal value for age and sex) to evaluate the impact of BNP activation on post-operative outcomes. Results: Mean age was73±11

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Kumar, Dilpat, Rehman Muhammad Ebad, Prashant Patel, and Tracey Mersfelder. "Abstract 14604: Flecainide Induced Myalgias. A Rare but Important Adverse Reaction." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.14604.

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Introduction: Flecainide is an anti-arrhythmic used in patients with symptomatic arrhythmias without structural heart anomalies. It is known to cause several non-cardiac adverse reactions, most commonly headaches, dizziness, fatigue and nausea. We report a case of symmetric polymyalgia, a rare side effect of flecainide. Case Report: A 62 year-old woman with history of atrial fibrillation presented with chest heaviness and generalized myalgias. Just 5 days prior to her presentation, she underwent a cardiac ablation and was started on flecainide 150 mg twice daily. Her other home medications inc

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Zhou, Lei, Zhiqiang Cheng, Peter Vanderslice, et al. "Abstract 9178: Cell-Based Prostacyclin Gene Therapy Prevents Pulmonary Arterial Hypertension." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a9178.

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Objectives: Intravenous prostacyclin is approved for the treatment of pulmonary arterial hypertension (PAH). However, it has limitations of a short half-life, the permanent placement of an intravenous catheter and substantial annual cost. We hypothesized that cell-based prostacyclin gene therapy may provide sustained therapeutic effects without the aforementioned limitations. Methods and Results: Since prostacyclin is produced from arachidonic acid by the enzymes cyclooxygenase (COX) and prostacyclin synthase (PGIS), we generated a vector expressing COX isoform 1 (COX1) and PGIS fusion protein

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Pfeiffer, Stefan P., Teresa Schnabel, Wolfgang Höpfner, Christiane Saadé, Rainer Zimmermann, and Hugo A. Katus. "Abstract 9789: Transient Elevation of Highly Sensitive Troponin T Levels in Patients With Documented Coronary Artery Disease Following Stress Myocardial Perfusion Imaging." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.9789.

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Introduction: Cardiac troponins are the preferred biomarkers of myocardial injury. More sensitive assays led to the detection of circulating troponins not only in myocardial infarction, but also in apparently healthy subjects after prolonged exercise. Hypothesis: In the era of highly sensitive troponin T (hs-TnT) tests we assesed the hypothesis that brief but intense exercise during diagnostic tests might cause elevated troponin levels in patients with stable coronary artery disease (CAD). Methods: Seventy-two patients (71% male, age 64±10 years) with documented CAD, LVEF >45%, normal renal

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Mikami, Yoko, Hajime Sakuma, Motonori Nagata, et al. "Abstract 2124: Accuracy of T2-weighted Cardiac Magnetic Resonance in Detecting Myocardial Edema in Acute Myocardial Infarction is Strongly Influenced by Microvascular Obstruction." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_460-b.

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Background: High signal intensity (SI) on T2-weighted Cardiac Magnetic Resonance (CMR) indicates infarct-associated myocardial edema in patients with acute myocardial infarction (MI). However, erythrocytes leaking from capillaries in infarct tissue may result in reduced signal on T2W CMR due to T2 shortening. The purpose of this study was to determine if detection of myocardial edema with T2-weighted CMR is influenced by microvascular obstruction (MO- ). Methods: Thirty-seven patients underwent black blood T2 weighted MRI with a spectral presaturation with inversion recovery fat saturation met

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Yano, Yuichiro, Norrina Allen, Guray Erus, et al. "Abstract 06: Long-term Blood Pressure Variability Throughout Young Adulthood and Mid-life Cerebrovascular Structure and Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study." Circulation 133, suppl_1 (2016). http://dx.doi.org/10.1161/circ.133.suppl_1.06.

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Introduction: In addition to average blood pressure (BP) values, BP variability has been suggested to be associated with lower cognitive function. It is unclear how long-term BP variability throughout young adulthood is associated with cerebrovascular structure (e.g., hippocampus) and function in midlife. Methods: Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, which recruited healthy young adults ages 18 to 30 years (mean age 25 years) in 1985-1986, we assessed average BP over visits and visit-to visit BP variability (average real variability [ARV], define

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Chaikriangkrai, Kongkiat, Hye Yeon Jhun, and Soma Jyothula. "Abstract 11065: Paradoxical Impact of Overweightness on Mortality in Lung Transplantation." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.11065.

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Background: Prognostic value of body mass index (BMI) and cardiorespiratory fitness (CRF) has been described extensively in various populations. The objective of this study was to examine impact of BMI and CRF on all-cause mortality in isolated lung transplant recipients. Methods: Consecutive isolated lung transplant recipients from 2008 to 2013 were identified. Pre-transplant cardio-metabolic risk factors were collected. The cohort was categorized using BMI into normal (BMI 18.5-24.9 kg/m 2 ), underweight (BMI < 18.5 kg/m 2 ), overweight (BMI 25.0-29.9 kg/m 2 ) and obese (BMI ≥ 30 kg/m 2 )

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Gorla, Riccardo, Rolf A. Janosi, Philipp Kahlert, et al. "Abstract 19096: D-dimer Profile and Prognostic Implication in Different Classes of Acute Aortic Syndromes." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.19096.

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Background: D-dimer has been reported to be elevated at presentation in acute aortic dissection (AAD). However, little is known about D-dimer in the setting of intramural hematoma (IMH) and penetrating aortic ulcer (PAU) as well as its time course during hospitalization. Methods: Clinical and laboratory data of 300 patients with acute aortic syndromes (208 AAD, 45 IMH and 47 PAU) were prospectively collected from 2000 to 2014. D-dimer blood levels were measured at presentation and daily during hospitalization with a latex-enhanced turbidometric test (250 μg/l upper limit of normal; D-dimer Plu

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Li, Zhu, Matthew Barajas, Takuro Oyama, and Matthias L. Riess. "Abstract 363: Endothelial Nitric Oxide Mediates Protection of Isolated Cardiomyocytes by Poloxamer 188 Against Hypoxia Reoxygenation Injury." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.363.

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Background: Poloxamer (P) 188, a copolymer-based cell membrane stabilizer, has been suggested to alleviate myocardial ischemia/reperfusion injury through cell membrane stabiliztion. Recent studies found that cell-to-cell interactions between endothelial cells (ECs) and cardiomyocytes (CMs) can further protect CMs: data from our co-culture model showed that ECs, at an appropriate density, promoted protection by P188 against hypoxia/reoxygenation (HR) injury evidenced by reduced release of lactate dehydrogenase (LDH) from CMs; however, the mechanism of interaction was yet to be explored. In the

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Yang, Quanhe, Mary Cogswell, W. Dana Flanders, et al. "Abstract MP089: Cardiovascular Protection Profile and All-cause and CVD Mortality among U.S. Adults." Circulation 125, suppl_10 (2012). http://dx.doi.org/10.1161/circ.125.suppl_10.amp089.

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Introduction: Epidemiologic studies suggest that multiple cardiovascular (CVD) protection-factors (i.e., non-smoking, physically active, normal blood pressure, normal blood glucose, normal total cholesterol, non-obese, and healthy diet) are associated with significantly reduced risk of cardiovascular disease incidence and mortality. Hypothesis: We assessed the hypothesis that the increased number of CVD protection-factors is associated with reduced risk for all-cause and CVD mortality and adherence to low CVD risk profile could result in significant lower rates of all-cause and CVD mortality.

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Canale, Maria Laura, Enrica Talini, Cristina Giannini, et al. "Abstract 4897: Right Ventricular Diastolic Dysfunction in Upper-normal and Mildly Hypertensives: A Tissue Doppler Imaging Study." Circulation 120, suppl_18 (2009). http://dx.doi.org/10.1161/circ.120.suppl_18.s1015-c.

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Background: Systemic hypertension is known to affect the right ventricle in addition to its wide-ranging effects on left ventricular structure and function. Whether upper-normal increments in systemic blood pressure (BP), sampled by ABPM, exert any effect on right ventricular function is, however, unknown at this point. Methods: Left (LV) and right ventricular (RV) diastolic longitudinal function were assessed by pulsed-wave TDI sampled at mitral (early:Em MIT and late:Am MIT ) and tricuspid (Em TRIC and Am TRIC ) annular level in a group of 98 (37F/61M, age: 46 ± 14yrs) otherwise normal subje

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Rizk, John, Melissa Soohoo, Leila Hashemi, et al. "Abstract 10683: Association Between Triglycerides and Incident Chronic Kidney Disease in Diabetics Across Stages of Albuminuria." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10683.

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Background: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Urine albumin to creatinine ratio (UACR) and albuminuria are critical components in CKD staging as well as a hallmark of diabetic kidney disease. We sought to evaluate the relationship of triglycerides (TG) with incident CKD in diabetic non-CKD patients, stratified by level of albuminuria, which has been less studied thus far. Methods: This study comprised of 99,705 diabetic non-CKD veterans with data on TG and MetS

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Raman, Jaishankar, Thomas Beaver, and Krishna Talluri. "Abstract 14749: Extra-cardiac Mitral Valve Repair - Experience With the Adjustable BACE Device." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.14749.

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Introduction: Functional mitral regurgitation (MR) is primarily due to abnormalities of the ventricular muscle in the presence of normal mitral leaflets. Present surgical treatment, repair or replacement, address the mitral valve annulus and leaflets, not the ventricular muscle. We describe our early and mid-term clinical experience with extra-cardiac treatment of MR with a novel, device that is implanted on a beating heart and can be adjusted remotely. Hypothesis: Evaluation of efficacy and outcomes Methods: Between Dec, 2008 and June, 2015, thirty one patients (mean age 59 years) with functi

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Mohmand, Mawa, Philimon N. Gona, Carol J. Salton, et al. "Abstract 15421: Effect of Sex and Age-group on Pulmonary Artery to Aorta Ratio in Healthy Aging: The Framingham Heart Study." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.15421.

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Introduction: An increased ratio of main pulmonary artery (MPA) to ascending aorta (AAo) diameters is associated with excess morbidity and mortality in COPD and pulmonary hypertension. We sought to determine: 1) whether MPA to AAo ratio (MPA:AAo) varies with sex and age in healthy adults; 2) normal upper 90 th percentile (P90) values for MPA:AAo; 3) effect of age on MPA:AAo in the general population. Methods: 1794 adults from the Framingham Heart Study Offspring cohort (65±9 y, 47% men) underwent ECG-gated T2-weighted black blood aortic CMR at 1.5T. MPA and AAo diameters were measured at MPA b

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