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Journal articles on the topic 'Normobaric oxygen paradox (NOP)'

Author: Grafiati

Published: 16 November 2024

Last updated: 31 July 2025

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1

Lafère, Pierre, Thomas Schubert, David De Bels, Peter Germonpré, and Costantino Balestra. "Can the normobaric oxygen paradox (NOP) increase reticulocyte count after traumatic hip surgery?" Journal of Clinical Anesthesia 25, no. 2 (2013): 129–34. http://dx.doi.org/10.1016/j.jclinane.2012.06.021.

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2

Fratantonio, Deborah, Fabio Virgili, Alessandro Zucchi, et al. "Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”." International Journal of Molecular Sciences 22, no. 1 (2021): 458. http://dx.doi.org/10.3390/ijms22010458.

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The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend of oxygen-sensitive transcription factors in human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects after one hour of exposure to mild (MH), high (HH) and very high (VHH) hyperoxia, c

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3

Balestra, Costantino, Sara Baldelli, Fabio Virgili, Michele Salvagno, Simona Mrakic-Sposta, and Deborah Fratantonio. "Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the “Normobaric Oxygen Paradox”." International Journal of Molecular Sciences 25, no. 4 (2024): 2394. http://dx.doi.org/10.3390/ijms25042394.

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The “normobaric oxygen paradox” (NOP) describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox-sensitive transcription factors. We have previously characterized the time trend of oxygen-sensitive transcription factors in human PBMCs, in which the return to normoxia after 30% oxygen is sensed as a hypoxic trigger, characterized by hypoxia-induced factor (HIF-1) activation. On the contrary, 100% and 140% oxygen induce a shift toward an oxidative stress response, characterized by NRF2 and NF-kB activation in the first 2

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4

Balestra, Costantino, Kate Lambrechts, Simona Mrakic-Sposta, et al. "Hypoxic and Hyperoxic Breathing as a Complement to Low-Intensity Physical Exercise Programs: A Proof-of-Principle Study." International Journal of Molecular Sciences 22, no. 17 (2021): 9600. http://dx.doi.org/10.3390/ijms22179600.

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Inflammation is an adaptive response to both external and internal stimuli including infection, trauma, surgery, ischemia-reperfusion, or malignancy. A number of studies indicate that physical activity is an effective means of reducing acute systemic and low-level inflammation occurring in different pathological conditions and in the recovery phase after disease. As a proof-of-principle, we hypothesized that low-intensity workout performed under modified oxygen supply would elicit a “metabolic exercise” inducing a hormetic response, increasing the metabolic load and oxidative stress with the s

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5

Debevec, Tadej, Michail E. Keramidas, Barbara Norman, Thomas Gustafsson, Ola Eiken, and Igor B. Mekjavic. "No Evidence For The "Normobaric Oxygen Paradox"." Medicine & Science in Sports & Exercise 43, Suppl 1 (2011): 151. http://dx.doi.org/10.1249/01.mss.0000403127.23300.30.

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6

Balestra, Costantino, Peter Germonpré, Jacques R. Poortmans, and Alessandro Marroni. "Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing: the “normobaric oxygen paradox”." Journal of Applied Physiology 100, no. 2 (2006): 512–18. http://dx.doi.org/10.1152/japplphysiol.00964.2005.

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Renal (peritubular) tissue hypoxia is a well-known physiological trigger for erythropoietin (EPO) production. We investigated the effect of rebound relative hypoxia after hyperoxia obtained under normo- and hyperbaric oxygen breathing conditions. A group of 16 healthy volunteers were investigated before and after a period of breathing 100% normobaric oxygen for 2 h and a period of breathing 100% oxygen at 2.5 ATA for 90 min (hyperbaric oxygen). Serum EPO concentration was measured using a radioimmunoassay at various time points during 24–36 h. A 60% increase ( P < 0.001) in serum EPO was ob

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7

Salvagno, Michele, Giacomo Coppalini, Fabio Silvio Taccone, et al. "The Normobaric Oxygen Paradox—Hyperoxic Hypoxic Paradox: A Novel Expedient Strategy in Hematopoiesis Clinical Issues." International Journal of Molecular Sciences 24, no. 1 (2022): 82. http://dx.doi.org/10.3390/ijms24010082.

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Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic organisms as it significantly affects a wide spectrum of physiological functions and energy production. Aerobic organisms activate countless molecular responses directed to respond at cellular, tissue, organ, and whole-body levels to cope with oxygen shortage allowing survival, including enhanced neo-angiogenesis and systemic oxygen delivery. The benefits of hypoxia may be evoked without its detrimental consequences by exploiting the so-called normobaric oxygen paradox. The intermittent shift between hypero

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8

Keramidas, Michail E., Ola Eiken, and Igor B. Mekjavic. "Prevailing evidence contradicts the notion of a “normobaric oxygen paradox”." European Journal of Applied Physiology 112, no. 12 (2012): 4177–78. http://dx.doi.org/10.1007/s00421-012-2394-9.

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9

Balestra, C., and P. Germonpré. "Hypoxia, a multifaceted phenomenon: the example of the “Normobaric Oxygen Paradox”." European Journal of Applied Physiology 112, no. 12 (2012): 4173–75. http://dx.doi.org/10.1007/s00421-012-2392-y.

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10

Balestra, C., and P. Germonpré. "Increasing EPO using the normobaric oxygen paradox: a ‘not so simple’ task." Acta Physiologica 203, no. 2 (2011): 287–88. http://dx.doi.org/10.1111/j.1748-1716.2011.02282.x.

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11

Keramidas, M. E., S. N. Kounalakis, T. Debevec, et al. "Acute normobaric hyperoxia transiently attenuates plasma erythropoietin concentration in healthy males: evidence against the ‘normobaric oxygen paradox’ theory." Acta Physiologica 202, no. 1 (2011): 91–98. http://dx.doi.org/10.1111/j.1748-1716.2011.02262.x.

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12

De Bels, D., F. Corazza, P. Germonpré, and C. Balestra. "The normobaric oxygen paradox: A novel way to administer oxygen as an adjuvant treatment for cancer?" Medical Hypotheses 76, no. 4 (2011): 467–70. http://dx.doi.org/10.1016/j.mehy.2010.11.022.

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13

Ciccarella, Y., C. Balestra, J. Valsamis, and P. Van der Linden. "Increase in endogenous erythropoietin synthesis through the normobaric oxygen paradox in cardiac surgery patients." British Journal of Anaesthesia 106, no. 5 (2011): 752–53. http://dx.doi.org/10.1093/bja/aer074.

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14

Zuccari, S., A. Donati, E. Damiani, R. Castagnani, N. Mininno, and P. Pelaia. "Normobaric oxygen paradox and erythropoietin production in critically ill patients: a prospective observational study." Critical Care 19, Suppl 1 (2015): P320. http://dx.doi.org/10.1186/cc14400.

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15

Cimino, F., C. Balestra, P. Germonpré, et al. "Pulsed high oxygen induces a hypoxic-like response in human umbilical endothelial cells and in humans." Journal of Applied Physiology 113, no. 11 (2012): 1684–89. http://dx.doi.org/10.1152/japplphysiol.00922.2012.

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It has been proposed that relative changes of oxygen availability, rather than steady-state hypoxic or hyperoxic conditions, play an important role in hypoxia-inducible factor (HIF) transcriptional effects. According to this hypothesis describing the “normobaric oxygen paradox”, normoxia following a hyperoxic event is sensed by tissues as an oxygen shortage, upregulating HIF-1 activity. With the aim of confirming, at cellular and at functional level, that normoxia following a hyperoxic event is “interpreted” as a hypoxic event, we report a combination of experiments addressing the effects of a

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16

Donati, A., E. Damiani, AT Colesnicenco, et al. "Normobaric oxygen paradox and the microcirculation in the critically ill patient: a prospective observational study." Critical Care 18, Suppl 1 (2014): P168. http://dx.doi.org/10.1186/cc13358.

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17

Busławski, Adam, Joachim Jarzyna, and Jerzy Zwoździak. "Biological mechanisms, therapeutic applications, clinical benefits and future perspectives of normobaric oxygen therapy: literature review." Medical Science Pulse 18, no. 4 (2024): 43–64. https://doi.org/10.5604/01.3001.0055.0364.

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Background: Normobaric oxygen therapy (NBO) is a widely used medical intervention aimed at enhancing oxygen delivery to tissues under atmospheric pressure. Recent studies have demonstrated its potential therapeutic benefits across various medical conditions, including stroke, traumatic brain injury, cardiovascular diseases, stress and mental disorders as well as wound healing.Aim of the study: This literature review aimed to summarize the biological mechanisms, therapeutic potential, and clinical outcomes of NBO exposures. Material and methods: A literature review was conducted, focusing on cl

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18

Debevec, Tadej, Michail E. Keramidas, Barbara Norman, Thomas Gustafsson, Ola Eiken, and Igor B. Mekjavic. "Acute short-term hyperoxia followed by mild hypoxia does not increase EPO production: resolving the “normobaric oxygen paradox”." European Journal of Applied Physiology 112, no. 3 (2011): 1059–65. http://dx.doi.org/10.1007/s00421-011-2060-7.

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19

Perović, Antonija, Marko Žarak, Marina Njire Bratičević, and Jerka Dumić. "Effects of recreational scuba diving on erythropoiesis–“normobaric oxygen paradox” or “plasma volume regulation” as a trigger for erythropoietin?" European Journal of Applied Physiology 120, no. 7 (2020): 1689–97. http://dx.doi.org/10.1007/s00421-020-04395-5.

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20

BALESTRA, COSTANTINO, PETER GERMONPRÉ, PIERRE LAFERE, YANNICK CICCARELLA, and PHILIPPE VAN DER LINDEN. "The ‘normobaric oxygen paradox’: a simple way to induce endogenous erythropoietin production and concomitantly raise hemoglobin levels in anemic patients." Transfusion Alternatives in Transfusion Medicine 11, no. 1 (2010): 39–42. http://dx.doi.org/10.1111/j.1778-428x.2010.01127.x.

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21

Ricerca, Bianca Maria, Salvatore Vagnoni, Anna Maria D’Amore, et al. "Erythropoietin Production in Vivo after a Fourteen Days Exposition to Hyperbarism." Blood 112, no. 11 (2008): 5398. http://dx.doi.org/10.1182/blood.v112.11.5398.5398.

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Abstract Six Italian scuba divers, three men and three women, lived permanently for 14 days at a depth of 8 – 10 metres under the sea level breathing a mixture with the same composition of the air at a pressure ranging between 1,8–2 ATA (Hyperoxic Air-HOA), under the control of a physician’s team. This experience called Abyss project: the “underwater home” was born as a Guinness record attempt, but it had been also surrounded by scientific attention giving the opportunity to collect scientific data. The effect of long-term diving on blood in professional and recreational-professional scuba div

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22

Khalife, Maher, Michele Salvagno, Maurice Sosnowski, and Costantino Balestra. "Exploring the effects of post operative hyperoxic intermittent stimuli on reticulocyte levels in cancer patients: a randomized controlled study." Journal of Anesthesia, Analgesia and Critical Care 4, no. 1 (2024). http://dx.doi.org/10.1186/s44158-024-00179-x.

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Abstract Background Anemia is common among hospitalized critically ill and surgical oncological patients. The rising incidence of cancer and aggressive treatments has increased the demand for blood products, further strained by a dwindling donor pool. The normobaric oxygen paradox (NOP) has emerged as a potential avenue to increase EPO levels. While some studies support its efficacy, research remains limited in clinical settings. This study aims to assess the effectiveness of a NOP protocol in stimulating erythropoiesis, as measured by changes in reticulocyte counts, in cancer patients undergo

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23

Khalife, Maher, Mohammed Ben Aziz, Costantino Balestra, Joseph Valsamis, and Maurice Sosnowski. "Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery." Frontiers in Physiology 12 (September 27, 2021). http://dx.doi.org/10.3389/fphys.2021.744074.

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The “Normobaric Oxygen Paradox” (NOP) is a physiologic mechanism that induces an increase of endogenous erythropoietin (EPO) production by creating a state of relative hypoxia in subjects previously exposed to hyperoxia, followed by a rapid return to normoxia. Oxygen exposure duration and inspired oxygen fraction required to observe a significant increase in EPO or hemoglobin are not clearly defined. Consequently, we here study the effect of one model of relative hypoxia on EPO, reticulocytes and hemoglobin stimulation in patients after surgery. Patients were prospectively randomized in two gr

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24

Theunissen, S., D. De Bels, J. Devriendt, et al. "The normobaric oxygen paradox: does it increase haemoglobin?" Critical Care 15, S1 (2011). http://dx.doi.org/10.1186/cc9842.

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25

Van Meter, Keith W. "Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review." Frontiers in Medicine 11 (October 8, 2024). http://dx.doi.org/10.3389/fmed.2024.1408816.

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For short periods, even without the presence of red blood cells, hyperbaric oxygen can safely allow plasma to meet the oxygen delivery requirements of a human at rest. By this means, hyperbaric oxygen, in special instances, may be used as a bridge to lessen blood transfusion requirements. Hyperbaric oxygen, applied intermittently, can readily avert oxygen toxicity while meeting the body's oxygen requirements. In acute injury or illness, accumulated oxygen debt is shadowed by adenosine triphosphate debt. Hyperbaric oxygen efficiently provides superior diffusion distances of oxygen in tissue com

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26

Ciccarella, Yannnick. "Increase of endogenous erythropoietin synthesis through the Normobaric Oxygen Paradox in cardiac surgery patients." BJA: British Journal of Anaesthesia 107, eLetters (2011). http://dx.doi.org/10.1093/bja/el_7094.

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27

Huggard, Joshua D., Nasimi A. Guluzade, James Duffin, and Daniel A. Keir. "The ventilatory response to modified rebreathing is unchanged by hyperoxic severity: implications for the hyperoxic hyperventilation paradox." Journal of Applied Physiology, November 9, 2023. http://dx.doi.org/10.1152/japplphysiol.00455.2023.

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Normobaric hyperoxia stimulates ventilation (V̇E) in a time- and dose-dependent manner. Whether this occurs via an oxygen (O2)-specific mechanism or secondary to carbon dioxide (CO2) retention at the central chemoreceptors remains unclear. We measured the ventilatory response to hyperoxic CO2 rebreathing with O2 clamped at increasingly higher pressures. We hypothesized that the V̇E versus PCO2 relationship is fixed and independent of PO2. On four occasions, twenty participants (10F; mean±SD age: 24±4 years) performed three repetitions of modified rebreathing in 4, randomized, isoxic-hyperoxic

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28

Silva, Gisele S., and Aneesh B. Singhal. "Abstract W P42: Ischemic Lesions Grow, but NIHSS Scores Improve Over 48 Hours After Stroke: Implications for Clinical Trials." Stroke 45, suppl_1 (2014). http://dx.doi.org/10.1161/str.45.suppl_1.wp42.

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Background: DWI lesion growth is often used as a surrogate outcome measure in early-phase stroke clinical trials. Several studies have shown that admission DWI volumes and 3-mth clinical outcomes are strongly correlated, and that DWI volumes and NIHSS scores correlate at various times after stroke. However, there are few quantitative data comparing the dynamic changes of NIHSS scores to DWI lesion growth in acute ischemic stroke. Methods: We analyzed data from a phase II clinical trial of normobaric oxygen therapy (NBO) in acute ischemic stroke. Patients ineligible for tPA with imaging-confirm

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