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Journal articles on the topic 'NORT'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lee, C. M. H., F. R. Tekpetey, D. T. Armstrong та M. W. Khalil. "Conversion of 5(10)-oestrene-3β,17β-diol to 19-nor-4-ene-3-ketosteroids by luteal cells in vitro: possible involvement of the 3β-hydroxysteroid dehydrogenase/isomerase". Journal of Endocrinology 129, № 2 (1991): 233–43. http://dx.doi.org/10.1677/joe.0.1290233.

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ABSTRACT We have previously suggested that in porcine granulosa cells, a putative intermediate, 5(10)-oestrene-3,17-dione is involved in 4-oestrene-3,17-dione (19-norandrostenedione; 19-norA) and 4-oestren-17β-ol-3-one (19-nortestosterone: 19-norT) formation from C19 aromatizable androgens. In this study, luteal cells prepared from porcine, bovine and rat corpora lutea by centrifugal elutriation were used as a source of 3β-hydroxysteroid dehydrogenase/isomerase in order to investigate the role of this enzyme in the biosynthesis of 19-norsteroids. Small porcine luteal cells made mainly 19-norT

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Truong-Bolduc, Que Chi, та David C. Hooper. "The Transcriptional Regulators NorG and MgrA Modulate Resistance to both Quinolones and β-Lactams in Staphylococcus aureus". Journal of Bacteriology 189, № 8 (2007): 2996–3005. http://dx.doi.org/10.1128/jb.01819-06.

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ABSTRACT MgrA is a known regulator of the expression of several multidrug transporters in Staphylococcus aureus. We identified another regulator of multiple efflux pumps, NorG, by its ability, like that of MgrA, to bind specifically to the promoter of the gene encoding the NorA efflux pump. NorG is a member of the family of the GntR-like transcriptional regulators, and it binds specifically to the putative promoters of the genes encoding multidrug efflux pumps NorA, NorB, NorC, and AbcA. Overexpression of norG produces a threefold increase in norB transcripts associated with a fourfold increas

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HANIM, NISFA, SALMAH WIDYASTUTI, ACHMAD ALFIYAN, MUHAMMAD AZHARI AKBAR, and BERRY JULIANDI. "Kompleksitas Obyek dan Running-Wheel Mempengaruhi Novel Object Recognition Test pada Mencit (Mus musculus)." Jurnal Sumberdaya Hayati 4, no. 1 (2018): 7–11. http://dx.doi.org/10.29244/jsdh.4.1.7-11.

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This research aimed to confirm the tendency of mice to novel object, effect of exercise (in running-wheel) toward memory of mice and to test tendency of mice in avoiding predator signal in novel object. Novel object recognition test (NORT) used to test the memory the day after acquisition phase (NORT I) and memory one week after exercise was given (running-wheel) (NORT II). The result showed that there was no tendency of mice in exploring toward novel object in both NORT I and NORT II. This might happen because the complexity of familiar object higher than novel object, so the familiar object

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Paisley, Helen, Helen Hartley, Anna Kearney, et al. "QOL-21. DEVELOPMENT AND UTILISATION OF A NEURO-ONCOLOGY REHABILITATION TEAM: 2018–2019 UPDATE." Neuro-Oncology 22, Supplement_3 (2020): iii435. http://dx.doi.org/10.1093/neuonc/noaa222.683.

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Abstract INTRODUCTION A multi-disciplinary Neuro-Oncology Rehabilitation Team (NORT) was established at our institution in 2014. We reviewed NORT inputs, processes and outputs in 2018 to 2019 compared to our previously presented data from 2015, soon after service inception. METHODS Retrospective analysis of patients who received NORT input June 2018 - May 2019 compared to 2015 data. Descriptive analysis of changes to NORT operational processes and structure. Complexity of rehabilitation needs was measured using the Rehabilitation Complexity Scale-Extended V13 (RCS). RESULTS 54 children receive

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Hajjar, Roger, François R. Querci, and Monique Querci. "The NORT: Network of Oriental Robotic Telescopes." International Astronomical Union Colloquium 183 (2001): 33–38. http://dx.doi.org/10.1017/s025292110007857x.

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AbstractIn this paper, we present the NORT, a network of oriental robotic telescopes originally proposed in 1993 by Querci & Querci to study stellar variability. The NORT project covers all of northern Africa and Asia near the tropic of Cancer. The interest generated among a number of astronomers in countries from the Arab World and Asia offers a solid basis for the rebirth of astronomy and astrophysics and space sciences in developing countries. The number of national projects for telescopes in different countries makes the NORT a framework of choice to coordinate and stimulate these sepa

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de Medeiros, Gabriela F., Pauline Lafenêtre, Yoottana Janthakhin, et al. "Corticosteroid-Binding Globulin Deficiency Specifically Impairs Contextual and Recognition Memory Consolidation in Male Mice." Neuroendocrinology 109, no. 4 (2019): 322–32. http://dx.doi.org/10.1159/000499827.

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Background/Aims: Glucocorticoids are essential in modulating memory processes of emotionally arousing experiences and we have shown that corticosteroid-binding globulin (CBG) influences glucocorticoid delivery to the brain. Here, we investigated the role of CBG in contextual and recognition long-term memory according to stress intensity. Method: We used adult male mice totally deficient in CBG (Cbg KO) or brain-specific Cbg KO (CbgCamk KO) to examine their performance in contextual fear conditioning (CFC) and auditory fear conditioning, both at short (1 h) and long-term (24 h). Long-term memo

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Farías Cabrejo, Naira Del Rocío, and Katherin Vanessa Orihuela Carrasco. "ESTRATEGIAS DE MAKETING MIX PARA LA CAPTACIÓN DE CLIENTES EN LA EMPRESA SERVISALUD NORT S.A.C., CHICLAYO." HORIZONTE EMPRESARIAL 7, no. 2 (2020): 135–44. http://dx.doi.org/10.26495/rce.v7i2.1483.

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La presente investigación tuvo como objetivo desarrollar estrategias de marketing mix que permitan captar clientes en la empresa Servisalud Nort S.A.C. Se realizó un estudio descriptivo y correlacional, aplicando un diseño no experimental – transversal. Se consideró como muestra un total de 50 clientes de la empresa Servisalud Nort S.A.C., a los cuales se les aplicó como técnica de recolección de datos la encuesta y como instrumento el cuestionario. La validez y confiabilidad del instrumento fueron validadas por expertos en la materia y por la aplicación del coeficiente de Conbrach, dando como

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Hartley, Helen, Barry Pizer, Ram Kumar, Joanne Owen, Helen Paisley, and Amillie White. "COVD-03. IMPACT OF COVID-19 ON THERAPY PROVISION FOR CHILDREN WITH CNS TUMOURS." Neuro-Oncology 22, Supplement_3 (2020): iii283. http://dx.doi.org/10.1093/neuonc/noaa222.034.

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Abstract INTRODUCTION The COVID-19 pandemic has led to widespread change in the delivery of rehabilitation. The Teenage Cancer Trust reported that 69% of young people with cancer saw their physiotherapist less than usual during the pandemic raising concerns about physiotherapy input. METHODS Retrospective analysis of all children’s therapy input managed under the Neuro Oncology Rehabilitation Team (NORT) between 1st April and 30th July 2020. Descriptive analysis of change to physiotherapy provision during this time period by Tertiary and local community services. RESULTS 49 children were manag

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Sopiah, Sopiah. "PENGARUH DESAIN KERJA DAN MANAJEMEN TEKNOLOGI INFORMASI TERHADAP MUTU PELAYANAN GURU SMK NEGERI DI WILAYAH JAKARTA UTARA." Jurnal Manajemen Pendidikan 8, no. 1 (2017): 172. http://dx.doi.org/10.21009/jmp.08116.

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This study aims to determine the effect of job design and management information technologi on service quality State Senior High School in Nort Jakarta.The method used ini this research is survey method with path analysis techniques. This study used a population of teachers State Senior High School in Nort Jakarta much as 150 teachers. Sampling techniques in this study is proportional random sampling methode.Based on the results of the study can be summarized as follows: Firstly, there is the effect of job design on service quality; Secondly, there is the effect of management information techn

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Velasquez, Pedro R., and Frank A. Williams. "Nan Ta Bayendo Nort (They Are Headed North)." Callaloo 21, no. 3 (1998): 520. http://dx.doi.org/10.1353/cal.1998.0195.

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Truong-Bolduc, Q. C., P. M. Dunman, T. Eidem, and D. C. Hooper. "Transcriptional Profiling Analysis of the Global Regulator NorG, a GntR-Like Protein of Staphylococcus aureus." Journal of Bacteriology 193, no. 22 (2011): 6207–14. http://dx.doi.org/10.1128/jb.05847-11.

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The GntR-like protein NorG has been shown to affectStaphylococcus aureusgenes involved in resistance to quinolones and β-lactams, such as those encoding the NorB and AbcA transporters. To identify the target genes regulated by NorG, we carried out transcriptional-profiling assays usingS. aureusRN6390 and its isogenicnorG::catmutant. Our data showed that NorG positively affected the transcription of global regulatorsmgrA,arlS, andsarZ. The three putative drug efflux pump genes most positively affected by NorG were the NorB efflux pump (5.1-fold), the MmpL-like protein SACOL2566 (5.2-fold), and

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Van Nort, Doug. "Doug Van Nort: DLCGO." Leonardo Music Journal 19 (December 2009): 107. http://dx.doi.org/10.1162/lmj.2009.19.107a.

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Ali, Mohd Sajid, Dileep Kumar, and Hamad A. Al-Lohedan. "Salt Effect on the Cloud Point Phenomenon of Amphiphilic Drug-Hydroxypropylmethyl Cellulose System." Journal of Chemistry 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/293972.

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Effect of two amphiphilic drugs (tricyclic antidepressant, nortriptyline hydrochloride (NORT), and nonsteroidal anti-inflammatory drug, sodium salt of ibuprofen (IBF)) on the cloud point of biopolymer hydroxypropylmethyl cellulose (HPMC) was studied. Effect of NaCl was also seen on the CP of HPMC-drug system. CP of HPMC increases uniformly on increasing the (drug). Both drugs, though one being anionic (IBF) and other cationic (NORT), affect the CP in almost the same manner but with different extent implying the role of hydrophobicity in the interaction between drug and polymer. Salt affects th

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Matthews, Donald G., Mona Khorani, Gerd Bobe, et al. "Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice." Journal of Alzheimer's Disease Reports 8, no. 1 (2024): 1611–38. https://doi.org/10.1177/25424823241296740.

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Background: Alzheimer's disease (AD) is a growing public health problem in the aging population, with limited treatment options. We previously reported that Centella asiatica herb water extract (CAW) attenuates cognitive decline in murine models of AD and aging. Objective: To explore changes in the hippocampal metabolome associated with CAW's modulation of cognitive function and amyloid-β (Aβ) plaque load in aged Tg2576 and wild-type (WT) mice. Methods: We compared cognitive function, hippocampal Aβ plaque burden, and hippocampal metabolite profile in 20-month-old Tg2576 female mice and their

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Bruzzone, Matteo, Elia Gatto, Tyrone Lucon Xiccato, et al. "Measuring recognition memory in zebrafish larvae: issues and limitations." PeerJ 8 (April 27, 2020): e8890. http://dx.doi.org/10.7717/peerj.8890.

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Recognition memory is the capacity to recognize previously encountered objects, events or places. This ability is crucial for many fitness-related activities, and it appears very early in the development of several species. In the laboratory, recognition memory is most often investigated using the novel object recognition test (NORt), which exploits the tendency of most vertebrates to explore novel objects over familiar ones. Despite that the use of larval zebrafish is rapidly increasing in research on brain, cognition and neuropathologies, it is unknown whether larvae possess recognition memo

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Abdalla, Sabna, Nermin Eissa, Petrilla Jayaprakash та ін. "The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice". International Journal of Molecular Sciences 24, № 16 (2023): 12719. http://dx.doi.org/10.3390/ijms241612719.

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The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, the procognitive effects of acute systemic administration of H3R antagonist E169 (2.5–10 mg/kg, i.p.) on MK801-induced amnesia in C57BL/6J mice using the novel object recognition test (NORT) were evaluated. E169 (5 mg) provided a significant memory-improving effect on MK801-induced short- and long-term memory impairments in NORT. The E169 (5 mg)-provided effects were comparable to those

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Hamady, Asmaa B., Noha M. Abd El-Fadeal, Samar Imbaby, Hassnaa MA Nassar, Mohamed Gamal Sakr, and Yara E. Marei. "Expression of norA, norB and norC efflux pump genes mediating fluoroquinolones resistance in MRSA isolates." Journal of Infection in Developing Countries 18, no. 03 (2024): 399–406. http://dx.doi.org/10.3855/jidc.18877.

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Introduction: Although fluoroquinolones are used to treat methicillin-resistant Staphylococcus aureus (MRSA)-induced infections, acquisition of antibiotic resistance by bacteria has impaired their clinical relevance. We aimed to evaluate the frequency of norA, norB, and norC efflux pump genes-mediating fluoroquinolones resistance and measure their expression levels in MRSA isolates. Methodology: 126 S. aureus isolates were collected from different clinical samples of adult hospitalized patients and identified by conventional microbiological methods. MRSA was diagnosed by cefoxitin disc diffusi

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Vinay, Vidya Shree, Malathi S, and Ravindran R. "IMPAIRED OBJECT RECOGNITION MEMORY AND ACETYLCHOLINESTERASE ACTIVITY IN ANIMAL MODEL OF POST-TRAUMATIC STRESS DISORDER-RESTORED BY ECLIPTA ALBA LINN. A DIETARY HERB." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 117. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14190.

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ABSTRACTObjective: Acetylcholinesterase (AChE) inhibitors are important therapeutic targets to treat memory impairment caused due to stress, post-traumaticstress disorder (PTSD) results from traumatic stress exposure. Cognition and mood symptoms can begin or worsen after the traumatic event. In thisstudy, we aimed to evaluate the role of Eclipta alba Linn. as an antistressor, AChE inhibitor, and on object recognition memory in an animal model of PTSD.Methods: Adult male Wistar albino rats were randomly divided into four groups: Control, chronic unpredictable stress (CUS) (30 days), CUS+ethanol

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Ducassou, Céline, Marc Poujol, Erwan Hallot, Olivier Bruguier, and Michel Ballevre. "Petrology and geochronology of the high-K calc-alkaline Mésanger magmatism (Armorican massif, France): a ca. 320 Ma old volcano-plutonic association." Bulletin de la Société Géologique de France 182, no. 6 (2011): 467–77. http://dx.doi.org/10.2113/gssgfbull.182.6.467.

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Abstract The late stages of the Variscan orogeny in western and central Europe are characterized by the emplacement of numerous Carboniferous granitic intrusions. In the southern part of the Armorican massif, volcanic and plutonic rocks occur within the Carboniferous series of the Ancenis basin. Chemical analyses indicate that they belong to the same magmatic high-K calc-alkaline association of peraluminous composition, which likely derives from crustal melting of an igneous source. A LA-ICPMS U-Pb/zircon age of 319.3 ± 3.1 Ma dates, for the first time, this magmatic event and, by there, const

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Adam, Adam, Bahari Bahari, and Fahria Nadiryati Sadimantara. "ANALISIS PENDAPATAN USAHATANI HOLTIKULTURA (Studi Kasus Agrowisata Awila Hills Kecamatan Molowe Kabupaten Konawe Utara)." Jurnal Ilmiah Inovasi dan Komunikasi Pembangunan Pertanian 1, no. 3 (2022): 44. http://dx.doi.org/10.56189/jiikpp.v1i3.28002.

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This study aims to (1) determine the cost and income of horticultural farming in Awila Hills agro-tourism, Molawe District, North Konawe Regency. (2) analyze the types of plants that contribut e the largest income to horticultural farming in Awila Hills Agro-tourism, Molawe District, Nort Konawe Regency. This research was conducted in Awila Hills Agrotourism, Molawe District, Nort Konawe Regency. The sampling method in this study was determined by a proportional sampling technique, namely taking samples with certain considerations. The number of samples in this study amounted to 1 horticultura

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Querci, François R., and Monique Querci. "Variability Studies with International Networks." Symposium - International Astronomical Union 177 (2000): 499–506. http://dx.doi.org/10.1017/s0074180900002771.

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Variable stars can be monitored through observing campaigns which coordinate multi-site telescopes at various longitudes. A new practice is now being developed, involving devoted networks of robotic telescopes. We will review these two technologies and will emphasize the NORT (Network of Oriental Robotic Telescopes) project, which we are promoting in Middle Eastern countries.

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Nortier, Jacomine. "Pomme van der Weerd. Nederlanders and buitenlanders. A sociolinguistic ethnographic study of ethnic categorization among secondary school pupils. Amsterdam: LOT, 2020. 251 blz. ISBN: 978-94-6093-365-3. €33,00." Nederlandse Taalkunde 26, no. 3 (2021): 416–20. http://dx.doi.org/10.5117/nedtaa2021.3.006.nort.

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Nortier, Jacomine. "Vormen en Functies van Meertaligheid in Oude Liederen uit de Lage Landen." Taal en Tongval 75, no. 2 (2023): 169–89. http://dx.doi.org/10.5117/tet2023.2.002.nort.

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Mohammed, Yimer, Gashaw Bimrew, and Lisanwork Nigatu. "CHARACTERIZATION OF FUTURE CLIMATE VARIABILITY IN OROMIA SPECIAL ZONE, NORTH EASTERN ETHIOPIA." International Journal of Scientific & Engineering Research 12, no. 09 (2021): 450–65. http://dx.doi.org/10.14299/ijser.2021.09.02.

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This study was undertaken in Oromia special zone of nort eastern Ethiopia to analyze future climate variability. Downscale future rainfall and temperature data from ensemble of three GCMs by RCP4.5 emission scenario using a web based software tool (Marksim GCM). Standard statistical descriptors and statistical software like Instat V3.37, MAKESENS, XLSTAT 2014 and Arc GIS 10.1 were employed for the analysis data.

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Nurdiana, Nurdiana. "Factors Affecting the Level of Hemoglobin on Junior High School Children on Coast Regional District of North Lombok." Biota 8, no. 1 (2015): 1–18. http://dx.doi.org/10.20414/jb.v8i1.54.

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Hemoglobin is the number of hemoglobin ain red blood cells that assessed in grams per decilitre. One of the problems in the hemoglobin is anemia. The prevalence of anemia in junior high school students aged 10-14 years old at 57.1%. anemia is caused by a decrease in hemoglobin levels. These levels can change at any time depending on various factors, especially in junior high school students who are still in its infancy. Therefore, the researchers wanted to know what are the factors that effect hemoglobin levels were in junior high school students in Nort Lombok region. The sampling technique w

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Trinovika Futri Dewi and Yasrida Nadeak. "Hubungan Sikap Dan Pengetahuan Ibu Menyusui Dengan Pemberian Asi Eksklusif Pada Bayi UPTD Puskesmas Sultan Daulat Kabupaten Subulussalam Tahun 2023." JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL 2, no. 3 (2024): 11–16. http://dx.doi.org/10.59024/jikas.v2i3.846.

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According to the Nort Sumatera Provincial Health Service, exclusive breastfeeding is given to babies 0-6 months were 20,394 with a percentage of 67%. This is experienced a decrease in 2018 in the percentage of exclusive breastfeeding in the province Nort Sumatera as much as 76%. This research aims to determine the relationship knowledge and attitudes of breastfeeding mothers towards exclusive breastfeeding in working area of the Sultan Daulat Health Care Center, Sublussalam City in 2023.This research uses a population cross-sectional research method in this study were all mothers who had chi

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TURAN, İnci, Veysel Haktan ÖZAÇMAK, and Hale SAYAN ÖZAÇMAK. "Melatonin Yaşlı Sıçanlarda Postoperatif Kognitif Disfonksiyonu İyileştirir: Oksidatif Stres, PSD95 ve Ca2+/Kalmodulin Bağımlı Protein Kinazın Önemi." Batı Karadeniz Tıp Dergisi 7, no. 2 (2023): 225–33. http://dx.doi.org/10.29058/mjwbs.1342979.

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Aim: Postoperative cognitive dysfunction (POCD) is usually seen in the aged patients in postoperative period. In the present study, we aimed to investigate the effects of melatonin on cognitive and synaptic dysfunction and oxidative stress in POCD model constructed by abdominal surgery in aged rats. Material and Methods: Twenty months old male Wistar rats were randomly allocated into the control group, melatonin treated-control group, surgery group and melatonin treated-surgery group. The novel object recognition test (NORT) was used to assess the postoperative co

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U., A. Garkuwa, W. Alhassan A., and Tanko Y. "Effect of Curcumin on Blood Glucose Level and Some Neurobehavioral Responses in Alloxan-induced Diabetic Swiss Albino Mice." Journal of Advances in Medical and Pharmaceutical Sciences 14, no. 1 (2017): 1–7. https://doi.org/10.9734/JAMPS/2017/34323.

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The aim of this study was to evaluate the effect of curcumin on blood glucose level and neurobehavioral response in Alloxan-induced diabetic Swiss Albino mice. The animals were divided into five (5) groups of four each (n=4). Group I served as control and received distilled water, group II, III, IV and V were diabetic and received olive oil 1 ml/kg, glibenclamide 1 mg/kg, curcumin 50 mg/kg and curcumin 100 mg/kg respectively. Diabetes was induced using Alloxan (150 mg/kg). All administrations were done for duration of 21 days. Blood glucose level was determined using glucose oxidase principle

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Campos Sánchez-Bordona, María Dolores. "La presencia de modelos cántabros en la arquitectura montañesa de León. La casa palacio de los Gómez de Caso en Burón." Estudios humanísticos. Geografía, historia y arte, no. 16 (February 4, 2021): 223. http://dx.doi.org/10.18002/ehgha.v0i16.6670.

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<span>The investigation is based in the palace of the noble family Gomez de Caso, situated in the village of Burón (león). This building is a good example of the lordly architecture at the begining of the XVII century in the nort artea of Leon's mountains, in which it, appears big influences of the tradicional architecture of Cantabria and Asturias.</span>

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Diaz, Alfonso, Claudia Escobedo, Samuel Treviño, et al. "Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42." Oxidative Medicine and Cellular Longevity 2018 (August 1, 2018): 1–13. http://dx.doi.org/10.1155/2018/1358057.

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An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of Aβ1–42 into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt;

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Komoltsev, Ilia, Daria Shalneva, Olga Kostyunina, et al. "Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?" International Journal of Molecular Sciences 24, no. 5 (2023): 4542. http://dx.doi.org/10.3390/ijms24054542.

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Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may be involved in distant hippocampal damage and the development of late posttraumatic behavioral pathology. CS-dependent behavioral and morphological changes were studied 3 months after TBI induced by lateral fluid percussion in 51 male Sprague–Dawley rats. CS was measured in the background 3 and 7 days and 1, 2 and 3 months after TBI. Tests including open field, elevated plus maze, object location, new object recognition tests (NORT) and Barnes maze with reversal learning were used to assess behavioral chang

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Zlatanova, Hristina Ivanova, Maria Todorova Georgieva-Kotetarova, Natalia Borisova Vilmosh, and Ilin Kostadinov Kandilarov. "Evaluation of the Effect of Cariprazine on Memory and Cognition in Experimental Rodent Models." International Journal of Environmental Research and Public Health 19, no. 22 (2022): 14748. http://dx.doi.org/10.3390/ijerph192214748.

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The main symptoms of schizophrenia are categorized as positive, negative, and cognitive. Cognitive impairments do not generally respond to antipsychotics. Cariprazine is a novel antipsychotic conceived with the idea that high affinity for D3 receptors may elicit a favorable response in the management of cognitive deficits. We evaluated the pro-cognitive properties of 14-day long pre-treatment with cariprazine (0.25, 0.5, and 1 mg/kg b.w. intraperitoneally) in experimental rodent models with scopolamine-induced memory impairment employing novel object recognition test (NORT), T-maze, Y-maze, an

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Takahashi, Junpei, Daisuke Yamada, Wakana Nagano, Yoshitake Sano, Teiichi Furuichi, and Akiyoshi Saitoh. "Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice." PLOS ONE 18, no. 11 (2023): e0294113. http://dx.doi.org/10.1371/journal.pone.0294113.

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Oxytocin (OXT) neurons project to various brain regions and its receptor expression is widely distributed. Although it has been reported that OXT administration affects cognitive function, it is unclear how endogenous OXT plays roles in cognitive function. The present study examined the role of endogenous OXT in mice cognitive function. OXT neurons were specifically activated by OXT neuron-specific excitatory Designer Receptors Exclusively Activated by Designer Drug expression system and following administration of clozapine-N-oxide (CNO). Object recognition memory was assessed with the novel

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Horká, Petra, Josefina Mavrogeni, Veronika Langová, et al. "Effects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in Gnathonemus petersii: A New Possible Model for Schizophrenia Research." Fishes 10, no. 5 (2025): 229. https://doi.org/10.3390/fishes10050229.

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In animal models, ketamine, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, induces schizophrenia-like symptoms, such as positive and negative symptoms, as well as cognitive deficits. In the present study, we evaluated the behavioral responses and the number of EODs (electric organ discharges) of the weakly electric fish Gnathonemus petersii using the novel object recognition task (NORT). We aimed to investigate whether pharmacological modulation of the glutamatergic system would impair cognitive functions by administering the NMDA receptor antagonist ketamine, and whether these impa

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Suma, Tanjina Akter, Nushrat Alam, Sheikh Zahir Raihan, et al. "Association of Antibacterial Susceptibility Profile with the Prevalence of Genes Encoding Efflux Proteins in the Bangladeshi Clinical Isolates of Staphylococcus aureus." Antibiotics 12, no. 2 (2023): 305. http://dx.doi.org/10.3390/antibiotics12020305.

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Expelling antibiotic molecules out of the cell wall through multiple efflux pumps is one of the potential mechanisms of developing resistance against a wide number of antibiotics in Staphylococcus aureus. The aim of this study was to investigate the association between the antibiotic susceptibility profile and the prevalence of different efflux pump genes i.e., norA, norB, norC, mepA, sepA, mdeA, qacA/B, and smr in the clinical isolates of S. aureus. Sixty clinical isolates were collected from a tertiary level hospital in Bangladesh. The disc diffusion method using ten antibiotics of different

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Fialová, Markéta, Jana Šírová, Věra Bubeníková-Valešová, and Romana Šlamberová. "The Effect of Prenatal Methamphetamine Exposure on Recognition Memory in Adult Rats." Prague Medical Report 116, no. 1 (2015): 31–39. http://dx.doi.org/10.14712/23362936.2015.43.

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The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspring was administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an

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Trisnawati, Dewi, Budi Hartono, and Dumasari Harahap. "Implementasi Kebijakan Pelayanan Informasi dan Dokumentasi dalam Meningkatkan Pelayanan Humas pada BPSDM Provinsi Sumatera Utara." Journal of Education, Humaniora and Social Sciences (JEHSS) 5, no. 4 (2023): 3141–50. http://dx.doi.org/10.34007/jehss.v5i4.1774.

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The objectives to be achieved are to know and analyze about: Implementation of Information and documentation service policies in improving Public Relations Services at the Human Resources Development Agency of North Sumatra Province and what factors support and hinder it. . This research uses a type of qualitative research that focuses on the Implementation of Information and Documentation Service Policies in Improving Public Relations Services at the Human Resources Development Agency by focusing on the flow of services and personnel willingness and competence in providing information and doc

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Yusha'u, Y., Aisha Aminu Hanafi, and Umar Muhammad Adam. "Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice." Nigerian Journal of Physiological Sciences 38, no. 2 (2023): 223–27. http://dx.doi.org/10.54548/njps.v38i2.11.

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Depression is a mental disorder characterized by depressive episodes, such as low mood, low self-esteem, feeling of guilt, and poor concentration. Depression has a high comorbidity with cognitive impairments. Studies have shown that cinnamon has anti-inflammatory antiviral, antihypertensive, antioxidant and anti-diabetic potentials. Therefore, the aim of the research was to assess the antidepressant effect of cinnamon on open-space forced swim-induced depression in mice. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group I: control (negative control) exposed to open-

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Horka, Petra, Josefina Mavrogeni, Veronika Langova, et al. "Effects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in Gnathonemus petersii: A New Possible Model for Schizophrenia Research." Fishes 10, no. 5 (2025): 229. https://doi.org/10.3390/fishes10050229.

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In animal models, ketamine, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, induces schizophrenia-like symptoms, such as positive and negative symptoms, as well as cognitive deficits. In the present study, we evaluated the behavioral responses and the number of EODs (electric organ discharges) of the weakly electric fish Gnathonemus petersii using the novel object recognition task (NORT). We aimed to investigate whether pharmacological modulation of the glutamatergic system would impair cognitive functions by administering the NMDA receptor antagonist ketamine, and whether

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Ding, Yanpeng, Yoshikuni Onodera, Jean C. Lee, and David C. Hooper. "NorB, an Efflux Pump in Staphylococcus aureus Strain MW2, Contributes to Bacterial Fitness in Abscesses." Journal of Bacteriology 190, no. 21 (2008): 7123–29. http://dx.doi.org/10.1128/jb.00655-08.

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ABSTRACT While remaining a major problem in hospitals, Staphylococcus aureus is now spreading in communities. Strain MW2 (USA400 lineage) and other community methicillin-resistant S. aureus strains most commonly cause skin infections with abscess formation. Multidrug resistance (MDR) efflux pumps contribute to antimicrobial resistance but may also contribute to bacterial survival by removal of environmental toxins. In S. aureus, NorA, NorB, NorC, and Tet38 are chromosomally encoded efflux pumps whose overexpression can confer MDR to quinolones and other compounds (Nor pumps) or tetracyclines a

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Kim, Seul-Ki, Da-Ae Kwon, Yong Sang Kim, Hak Sung Lee, Hyun Kyu Kim, and Won-Ki Kim. "Standardized Extract (HemoHIM) Protects against Scopolamine-Induced Amnesia in a Murine Model." Evidence-Based Complementary and Alternative Medicine 2021 (March 17, 2021): 1–11. http://dx.doi.org/10.1155/2021/8884243.

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HemoHIM is a medicinal herbal preparation of Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia lactiflora Pallas (Paeoniaceae) designed for immune regulation. In the present study, the memory-enhancing effects of a standardized extract (HemoHIM) on scopolamine-induced memory impairment in a murine model was investigated. To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally (i.p.) injected into mice 30 min before the start of behavioral tests. The Y-maze, novel object recognition test (NORT), and passive avoidance task (PAT) were used to evoke memo

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Ramadan, Wafaa S., and Saleh Alkarim. "Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer’s Model." Cells 10, no. 12 (2021): 3511. http://dx.doi.org/10.3390/cells10123511.

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Patients suffering from Alzheimer’s disease (AD) are still increasing worldwide. The development of (AD) is related to oxidative stress and genetic factors. This study investigated the therapeutic effects of ellagic acid (EA) on the entorhinal cortex (ERC), which plays a major role in episodic memory, in the brains of an AD rat model. AD was induced using AlCl3 (50 mg/kg orally for 4 weeks). Rats were divided into four groups: control, AD model, EA (treated with 50 mg/kg EA orally for 4 weeks), and ADEA (AD rats treated with EA after AlCl3 was stopped) groups. All rats were investigated for ep

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Silva, José Givanildo da, Mariana de Barros, Nataly Diniz de Lima Santos, et al. "Antimicrobial activity of polypyrrole nanoparticles and aqueous extract of Moringa oleifera against Staphylococcus spp. carriers of multi-drug efflux system genes isolated from dairy farms." Journal of Dairy Research 87, no. 3 (2020): 309–14. http://dx.doi.org/10.1017/s0022029920000874.

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AbstractOur objectives were to identify genes of the multi-drug efflux system and to evaluate the antimicrobial activities of polypyrrole nanoparticles (PPy-NPs) and aqueous extract of Moringa oleifera against Staphylococcus spp. isolated from dairy farms in Northeast Brazil. Initially, 162 Staphylococcus spp. isolates were subjected to in vitro antimicrobial sensitivity tests. Of these, 35 presented antimicrobial multi-drug resistance phenotypes. These 35 isolates were then referred for the detection of norA, norB, norC, msrA, mgrA, tet-38, and lmrS genes, all of which feature in multi-drug e

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PAUW, R. M. DE, T. F. TOWNLEY-SMITH, J. M. CLARKE, T. N. McCAIG, and D. S. McBEAN. "LANCER HARD RED SPRING WHEAT." Canadian Journal of Plant Science 66, no. 2 (1986): 409–12. http://dx.doi.org/10.4141/cjps86-056.

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Lancer hard red spring wheat (Triticum aestivum L.) combines a high level of stem solidness which confers resistance to wheat stem sawfly (Cephus cinctus Nort.) with improved resistance to common root rot (Bipolaris sorokiniana (Sacc. in Sorok.) Shoem.) and seed shattering. It is adapted to the Brown and Dark Brown soil zones of Alberta and Saskatchewan and should be a suitable replacement for Canuck. It was licensed on 15 May 1985. Breeder seed of Lancer will be maintained by Agriculture Canada Research Station, Regina, Saskatchewan.Key words: Wheat (spring), cultivar decription

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DeMarco, Carmen E., Laurel A. Cushing, Emmanuel Frempong-Manso, Susan M. Seo, Tinevimbo A. A. Jaravaza, and Glenn W. Kaatz. "Efflux-Related Resistance to Norfloxacin, Dyes, and Biocides in Bloodstream Isolates of Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 51, no. 9 (2007): 3235–39. http://dx.doi.org/10.1128/aac.00430-07.

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ABSTRACT Efflux is an important resistance mechanism in Staphylococcus aureus, but its frequency in patients with bacteremia is unknown. Nonreplicate bloodstream isolates were collected over an 8-month period, and MICs of four common efflux pump substrates, with and without the broad-spectrum efflux pump inhibitor reserpine, were determined (n = 232). A reserpine-associated fourfold decrease in MIC was considered indicative of efflux. Strains exhibiting efflux of at least two of the four substrates were identified (“effluxing strains” [n = 114]). For these strains, MICs with or without reserpi

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Dastan, Dara, Iraj Salehi, Alireza Komaki, et al. "Protective effects of the traditional herbal formulation on oxidative stress, learning and memory in the animal model of type 2 diabetes." Physiology and Pharmacology 24, no. 3 (2020): 174–84. http://dx.doi.org/10.32598/ppj.24.3.30.

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Introduction: Diabetes mellitus (DM) is one of the most frequent metabolic diseases that affect various body systems. Cognitive impairment caused by diabetes is gaining more acceptance and attention. In this study, we have investigated the effects of a traditionally herbal formulation (THF) on oxidative stress (OS) and cognitive deficits in type 2 diabetic rats. Methods: Thirty-six male Wistar rats were divided into six groups: control group, diabetic group, diabetic+100, 200 or 300mg/kg THF, diabetic+glibenclamide (G) 5mg/kg. Streptozotocin-nicotinamide was used to induce type-II diabetes mel

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Rocchetti, Jill, Caroline Fasano, Gregory Dal-Bo, et al. "Persistent extrasynaptic hyperdopaminergia in the mouse hippocampus induces plasticity and recognition memory deficits reversed by the atypical antipsychotic sulpiride." PLOS ONE 18, no. 8 (2023): e0289770. http://dx.doi.org/10.1371/journal.pone.0289770.

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Evidence suggests that subcortical hyperdopaminergia alters cognitive function in schizophrenia and antipsychotic drugs (APD) fail at rescuing cognitive deficits in patients. In a previous study, we showed that blocking D2 dopamine receptors (D2R), a core action of APD, led to profound reshaping of mesohippocampal fibers, deficits in synaptic transmission and impairments in learning and memory in the mouse hippocampus (HP). However, it is currently unknown how excessive dopamine affects HP-related cognitive functions, and how APD would impact HP functions in such a state. After verifying the p

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Antai, Atim, Imoh Ukoh, Bisong Sunday, Emem Edet, and Martha Johnny. "Gestational administration of aqueous leaf extract of Jatropha tanjorensis alleviated postpartum emotional and cognitive dysfunction in rats (Wistar strain)." Nigerian Journal of Physiological Sciences 38, no. 2 (2023): 211–21. http://dx.doi.org/10.54548/njps.v38i2.10.

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This study examines the effect of gestational administration of aqueous leaf extract of Jatropha tanjorensis (JT) on postpartum-like behavioural outcomes to delineate its possibility as a prophylactic, therapeutic agent in the treatment of postpartum symptoms. Inseminated female rats (120-150g) were grouped into two-control and JT group (n=10). Control received 20 ml/kg of distilled water and JT group received 500 mg/kg of JT orally once daily for 21 days in gestation. Non-pregnant rats were excluded from the study. Parameters assessed at postpartum include antidepressant-like (force swim test

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Mankovsky, I. A. "Institution as Principle Notion of Institutionalism: Definition Problems." Vestnik of the Plekhanov Russian University of Economics, no. 1 (January 26, 2024): 5–16. http://dx.doi.org/10.21686/2413-2829-2024-1-5-16.

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The article analyzes approaches to defining institution being a central notion of institutionalism. It is clear that the term ‘institution’ is used by Russian economics in different meaning and the same is true for other humanitarian and social sciences, which points to inter-disciplinary nature of the notion. Apart from this, in institutionalism itself, due to different academic approaches to institutional economic theory there are various approaches to defining the notion ‘institution’, which, according to the author, hinders the dynamic development of institutionalism and thus requires corr

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Ferizaldi, Kismartini, Suwitri Sri, and Warsono Hardi. "Nort Aceh Commmunity Social Capital in Poverty Alleviation." International Journal of Innovative Science and Research Technology 7, no. 6 (2022): 911–17. https://doi.org/10.5281/zenodo.6812574.

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North Aceh Regency, which is one of the regencies of Aceh Province with the largest population of poor people, Based on data published by the Central Statistics Agency (BPS) in 2017 shows that North Aceh is the poorest area in Aceh with a total poor population of 115.06 thousand people, or 19, 46% of the total population. This condition is very ironic in the midst of the implementation of Indonesia's special autonomy status in Aceh with more powers as a result of the peace agreement between the Government of Indonesia and the Free Aceh Movement (GAM). Many policies have been taken to overc

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