Relevant bibliographies by topics / Nosocomial Sepsis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Nosocomial Sepsis'

Author: Grafiati
Published: 4 September 2021
Last updated: 18 February 2022

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Journal articles on the topic "Nosocomial Sepsis"

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Ray, Pallab, Anindita Das, Vikas Gautam, Neetu Jain, J. D. Wig, and Meera Sharma. "POSTOPERATIVE NOSOCOMIAL ENTEROBACTER SAKAZAKII SEPSIS." ANZ Journal of Surgery 77, no. 10 (October 2007): 915–16. http://dx.doi.org/10.1111/j.1445-2197.2007.04276.x.

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Pellicone, M., H. C. Neu, N. X. Chin, M. Fracaro, J. Bissinger, and H. Bopp. "Nosocomial klebsiella sepsis following hemodialysis." American Journal of Infection Control 15, no. 2 (April 1987): 90. http://dx.doi.org/10.1016/0196-6553(87)90041-1.

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Yadav, Sunil Kumar, SP Yadav, P. Kanodia, N. K. Bhatta, R. R. Singh, and B. Khanal. "Nosocomial Sepsis and its Risk Factors: A Cross-Sectional Study in a Neonatal Intensive Care Unit." Journal of BP Koirala Institute of Health Sciences 2, no. 1 (July 24, 2019): 52–59. http://dx.doi.org/10.3126/jbpkihs.v2i1.24970.

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Introduction: Nosocomial sepsis is a common and serious infection of neonates who are admitted in intensive care unit. They lead to significant morbidity and mortality in both developed and resource limited countries. The neonatal intensive care unit (NICU) is a suitable environment for disseminating the infections and, hence, needs preventive intervention. The study was carried out to determine the risk factors for nosocomial sepsis in neonatal intensive care unit. Material and Methods: This was a cross-sectional study conducted in a seven bedded teaching and referral hospital NICU. All neonates in NICU who did not have any sign of infection at admission and remained hospitalized for at least 48 hours were observed. Nosocomial sepsis was diagnosed according to the CDC criteria. Risk factors for nosocomial sepsis were analyzed with Chi-square test and Logistic regression model. P-value of <0.05 was considered significant. Results: Low birth weight (both preterm and IUGR) and mechanical ventilation were found to be related with nosocomial sepsis. Conclusions: Low birth weight and mechanical ventilation were the most important risk factors fornosocomial sepsis.
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Snydman, David R. "Nosocomial Sepsis Associated with Interleukin-2." Annals of Internal Medicine 112, no. 2 (January 15, 1990): 102. http://dx.doi.org/10.7326/0003-4819-112-2-102.

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Kumar, Ashwani, and Praveen Kumar. "Nosocomial sepsis surveillance in the NICU." Journal of Neonatology 23, no. 1 (March 2009): 34–43. http://dx.doi.org/10.1177/0973217920090106.

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Auriti, Cinzia, Ersilia Fiscarelli, Maria Paola Ronchetti, Marta Argentieri, Gabriella Marrocco, Anna Quondamcarlo, Giulio Seganti, et al. "Procalcitonin in detecting neonatal nosocomial sepsis." Archives of Disease in Childhood - Fetal and Neonatal Edition 97, no. 5 (August 29, 2012): F368—F370. http://dx.doi.org/10.1136/fetalneonatal-2010-194100.

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Hugonnet, Stéphane, Hugo Sax, Philippe Eggimann, Jean-Claude Chevrolet, and Didier Pittet. "Nosocomial Bloodstream Infection and Clinical Sepsis." Emerging Infectious Diseases 10, no. 1 (January 2004): 76–81. http://dx.doi.org/10.3201/eid1001.030407.

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Hamory, Bruce H. "Nosocomial sepsis related to intravascular access." Critical Care Nursing Quarterly 11, no. 4 (March 1989): 58–65. http://dx.doi.org/10.1097/00002727-198903000-00007.

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Wood, M. J. "Chemotherapy for Gram-Positive Nosocomial Sepsis." Journal of Chemotherapy 11, no. 6 (December 1999): 446–52. http://dx.doi.org/10.1179/joc.1999.11.6.446.

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Heenen, Sarah, Frédérique Jacobs, and Jean-Louis Vincent. "Antibiotic strategies in severe nosocomial sepsis." Critical Care Medicine 40, no. 5 (May 2012): 1404–9. http://dx.doi.org/10.1097/ccm.0b013e3182416ecf.

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Dissertations / Theses on the topic "Nosocomial Sepsis"

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Cárdenas, Argumedo Aníbal Rolando. "Factores asociados a sepsis nosocomial en el Servicio de Neonatología del Hospital Militar Central, 2009." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2010. https://hdl.handle.net/20.500.12672/13326.

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El documento digital no refiere asesor
El presente trabajo estuvo orientado a determinar los factores asociados a sepsis nosocomial en los recién nacidos en el servicio de neonatología de Hospital Militar Central, para ello se realizó un estudio, descriptivo, retrospectivo, de casos y controles. La muestra seleccionada estuvo comprendida por 136 neonatos que desarrollaron sepsis intrahospitalaria clínica atendidos en el periodo que corresponde al estudio. Los instrumentos empleados estuvieron conformados por una ficha de recolección de datos convenientemente elaborados para los fines de estudio.
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Uhel, Fabrice. "Cellules suppressives d'origine myéloïde au cours du sepsis." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B002/document.

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Le sepsis est à l’origine d’une dysfonction immunitaire prolongée responsable d’infections nosocomiales et d’une mortalité tardive élevée. Sa physiologie complexe demeure mal connue et il n’existe aucun traitement spécifique en dehors de l’antibiothérapie et des thérapeutiques de suppléance d’organes. Nous nous sommes intéressés au rôle des cellules myéloïdes dans cette dysfonction immunitaire. Nous avons pu montrer qu’il existe chez les patients atteints de sepsis une augmentation du nombre de cellules suppressives d’origine myéloïde monocytaires (M-MDSC) CD14+HLA-DRlow/- et granulocytaires (G-MDSC) identifiées comme des granulocytes de faible densité CD14-CD15+. Ces cellules sont responsables d’une activité Indoléamine 2,3-dioxygénase (IDO) et arginase 1, et leur déplétion permet de restaurer la prolifération des lymphocytes T in vitro. L’augmentation précoce des G-MDSC prédit la survenue ultérieure d’infections nosocomiales. De même, l’augmentation de l’activité IDO et de l’arginase 1 plasmatique sont associées à un mauvais pronostic. Au total, nous avons pu démontrer que les cellules myéloïdes acquièrent un phénotype suppresseur en partie responsable de l’immunodépression acquise et du pronostic péjoratif chez les patients septiques. Afin de restaurer les capacités immunitaires des patients, les MDSC pourraient devenir une future cible thérapeutique
Sepsis results in a sustained immune dysfunction responsible for poor prognosis and nosocomial infections. Sepsis physiology remains poorly understood and no treatment exists currently, excepted from antibiotherapy and life-support techniques. We asked if myeloid cells could play a role in this sustained immune dysfunction. We demonstrated that Peripheral CD14+HLA-DRlow/- monocytic-myeloid-derived suppressor cells (MDSCs) and CD14-CD15+ low-density granulocytes identified as granulocytic- (G-)MDSCs were increased in septic patients. In vitro, arginase and IDO activities relied on MDSCs and depletion of both subsets restored T-cell proliferation. The initial proportion of G-MDSC predicted occurrence of nosocomial infections. Similarly, high plasma Indoleamine 2,3-dioxygenase (IDO) activity and arginase 1 level were associated with poor outcome. Altogether, our results demonstrate that myeloid cells acquire suppressive functions during sepsis, partially responsible for the sustained immune dysfunction and poor outcome. MDSCs may become a future therapeutic target to restore the immune capacities of septic patients
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Butin, Marine. "Staphylococcus capitis en réanimation néonatale : épidémiologie, caractérisation moléculaire et physiopathologie." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1074.

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Les infections néonatales tardives (INT, survenant après 3 jours de vie) sont fréquentes et sont associées à une mortalité et une morbidité importantes chez les nouveau-nés prématurés. Dans ce contexte, il a été récemment décrit un clone de Staphylococcus capitis, appelé NRCS-A, impliqué spécifiquement dans ces INT dans différents services de réanimation néonatale (RN) à travers la France, et présentant un profil multirésistant atypique chez cette espèce, incluant notamment une sensibilité diminuée à la vancomycine, qui est pourtant l'antibiotique de première ligne en cas de suspicion d'INT. Dans le cadre de ce travail, nous avons démontré la distribution endémique du clone NRCS-A dans au moins 17 pays à travers le monde, spécifiquement dans les services de RN. De plus des données épidémiologiques issues des services de RN français ont identifié une prévalence élevée du clone dans certains services, illustrant sa capacité à s'implanter puis à persister dans ces services. Une caractérisation génétique du clone NRCS-A a été réalisée afin de mettre en évidence d'éventuels facteurs génétiques pouvant favoriser son implantation dans les services de RN. Cette analyse a démontré le rôle des éléments génétiques mobiles dans l'émergence du phénotype multirésistant du clone NRCS-A. En revanche aucun gène de virulence spécifique du clone n'a pu être mis en évidence. L'analyse des gènes spécifiques du clone a toutefois permis d'identifier le gène nsr codant pour la résistance à la nisine, bactériocine active sur de nombreuses bactéries à Gram positif et sécrétée par les bactéries de la flore commensale digestive. Ce gène pourrait donc conférer un avantage sélectif au clone NRCS-A pour s'implanter dans le microbiote des nouveau-nés prématurés. La persistance du clone dans les services de RN évoque la présence de réservoirs inertes ou humains au sein de ces services. Grâce à la mise au point d'une technique d'identification de S. capitis par gélose chromogénique sélective, nous avons pu démontrer la diffusion et la persistance de S. capitis dans un service de RN, sans toutefois identifier un réservoir unique responsable de cette colonisation. Nous avons également observé une inefficacité partielle des mesures de décontamination. Il n'existe en revanche pas de portage chronique chez le personnel soignant, ni de colonisation vaginale chez les femmes enceintes. Par ailleurs, nous avons pu mettre en évidence par repiquages successifs in vitro une capacité particulière du clone NRCS-A à acquérir de façon rapide et stable une résistance à la vancomycine sous pression de sélection par cet antibiotique. Cette capacité constitue un avantage sélectif majeur pour ce clone et pourrait avoir favorisé son implantation et sa persistance dans les services de RN où la pression de sélection par la vancomycine est élevée. Pour compléter ces résultats, une étude de cohorte prospective menée en RN a permis de démontrer que l'administration de vancomycine constituait un facteur de risque indépendant de survenue d'INT à S. capitis. Au-delà de la problématique spécifique des INT à S. capitis en RN, nos travaux illustrent plus largement un des enjeux majeurs de santé publique qui est l'impact écologique potentiel de l'utilisation des antibiothérapies probabilistes à large spectre sur l'émergence et la sélection de bactéries multirésistantes impliquées secondairement dans des infections nosocomiales. Ces travaux ouvrent de nouveaux axes de recherche concernant d'une part la meilleure compréhension de la physiopathologie des INT à S. capitis, et d'autre part plus largement les modalités de prévention des INT en RN et d'amélioration du diagnostic précoce des INT
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WESTBROOK, JANELLE LIANNA. "EVIDENCE BASED RECOMMENDATIONS FOR TREATING AND REDUCING THE INCIDENCE OF NOSOCOMIAL NEONATAL SEPSIS IN THE INTENSIVE CARE SETTING: A BEST PRACTICE APPROACH." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613765.

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The purpose of this thesis is to develop an educational sheet that could be kept on-hand in the Neonatal Intensive Care Unit (NICU) as a reference for a group of evidence-based recommendations designed to reduce the rates of neonatal sepsis. This handout includes information regarding primary and secondary interventions, as well as signs and symptoms of sepsis. The primary interventions include healthcare worker hygiene and evidence-based practice for caring for patients with central venous catheters. The secondary interventions include antibiotic treatment information.
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Guignant, Caroline. "Biomarqueurs des états septiques sévères : vers de nouvelles stratégies thérapeutiques individualisées." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00744932.

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En dépit de nombreux essais thérapeutiques, les syndromes septiques sont la première cause de mortalité en service de soins intensifs. La population septique étant très hétérogène, une meilleure caractérisation des patients serait essentielle afin de mieux individualiser et cibler les thérapeutiques potentiellement bénéfiques. Une approche multiparamétrique de l'utilisation des biomarqueurs est une alternative qui viserait à appréhender la situation de manière plus globale. Notre travail s'inscrit dans ce contexte au travers de l'étude plus spécifique de la défaillance des systèmes cardio-vasculaire et immunitaire. Au-delà de la confirmation de l'intérêt des biomarqueurs présentement étudiés (prohormones cardio-vasculaires et PD-1) dans la prédiction de la mortalité et du risque d'infections nosocomiales, nos résultats apportent des éléments nouveaux. Nous avons montré que (1) la sur-expression des molécules PD-1 est associée à l'énergie leucocytaire, (2) un même biomarqueur peut apporter une information différente au cours du temps, (3) l'information apportée par l'analyse simultanée de deux biomarqueurs est supérieure à celle de la somme de leurs valeurs individuelles, et (4) l'expression dynamique d'un biomarqueur est meilleure que son expression à un temps donné. Au total, notre travail illustre l'intérêt potentiel d'un panel de biomarqueurs pour mieux appréhender la complexité des états septiques et leur rapide évolution. Il reste néanmoins à développer des outils biostatistiques capables de donner au clinicien une vision globale en temps réel des processus en cours. Cela constituera une étape clé pour mieux stratifier et cibler les prochains essais cliniques dans le domaine.
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Lugo, Trampe Aldo, and Alcántara Elia Santiago. "Factores de riesgo asociados a Sepsis Nosocomial en recién nacidos pre termino del Servicio de Neonatología, Hospital General Dr. Nicolás San Juan Un estudio de casos." Tesis de Licenciatura, Medicina-Quimica, 2014. http://ri.uaemex.mx/handle/20.500.11799/14919.

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Las definiciones de sepsis y los procesos relacionados con ̩sta se introdujeron inicialmente en los adultos. En 1992 se reúne el consenso de la American College of Critical Care Medicine y Society of Critical Care Medicine (por sus siglas en ingles: ACCM-SCCM) y se mencionan por primera vez términos como: síndrome de respuesta inflamatoria sist̩émica (SIRS), sepsis severa, shock s̩ptico y síndrome de disfunción multiorgánica. En 2001, durante la segunda Conferencia Internacional se propone que la definición de sepsis se haga con base en marcadores biológicos, pero no se obtiene el impacto esperado. En 2004 se reúne el Foro Internacional de Sepsis, el cual crea un consenso para definir parámetros de sepsis en pacientes pediátricos y neonatales. 1
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Nelson, Tasha K. "A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus aureus and Other Wound Pathogens." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3911.

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Skin related injuries are some of the most dangerous forms of wounds. In addition to treating the wound itself, health care providers must be cautious of microbial infections. In this study, we evaluate a novel all-natural antimicrobial gel compound (AMG) designed to kill planktonic bacteria, penetrate bacterial biofilms, and accelerate wound healing. In -vitro experiments demonstrate that AMG is effective in inhibiting planktonic growth and biofilm development of eight common pathogens. LIVE/DEAD staining and confocal microscopy reveal that planktonic growth and three-dimensional structure of biofilms were significantly reduced. Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) was used to investigate a small panel of genes (PrsA, Sprx) and showed potential targets for future study. A physiologically relevant wound model was created for treating S. aureus infections by using AMG alone or in combination with a common topical antibiotic, Mupirocin. AMG is a safe and effective treatment option for skin related infection.
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Jellimann, Jean-Marc Hascoët Jean-Michel. "Les septicémies nosocomiales en néonatologie influence de l'antibiothérapie et vers un bon usage des antibiotiques /." [S.l.] : [s.n.], 2002. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2002_JELLIMANN_JEAN_MARC.pdf.

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Ramírez, Calderón Fanny Elizabeth, and Gálvez José Tobias Zúñiga. "Estratificación del riesgo de mortalidad por sepsis en el Servicio de Emergencia Adultos del Hospital Nacional Edgardo Rebagliati Martins EsSalud : abril-junio 2004." Universidad Nacional Mayor de San Marcos. Programa Cybertesis PERÚ, 2004. http://www.cybertesis.edu.pe/sisbib/2004/ramirez_cf/html/index-frames.html.

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Con el fin evaluar el MEDS score, en pacientes con sepsis o sospecha de sepsis en el servicio de Emergencia adultos del HNERM. y determinar la validez de dicho score en nuestro medio, se realiza el presente estudio en 240 pacientes que cumplieron los criterios de inclusión establecidos. Objetivos: a) Estratificar mediante el MEDS score , pacientes con sepsis o sospecha de sepsis en diferentes niveles de riesgo. b) Conocer la frecuencia de mortalidad.por sepsis c) Determinar el grado de correlación entre los diferentes niveles de riesgo y sus índices de mortalidad. d) Proponer la aplicación de guías de atención ajustadas al riesgo que permitan mejorar el pronóstico de los pacientes sépticos en el servicio de emergencia. Tipo de estudio: Descriptivo, prospectivo, longitudinal. Lugar: Servicio de Emergencia Adultos del HNERM. Métodos y Resultados: Los pacientes fueron estratificados mediante MEDS score según niveles de riesgo de mortalidad: obteniéndose los siguientes resultados : Muy Bajo (10,00%), Bajo ( 19,17% ), Moderado ( 29,58%); Alto (17,92%) y Muy Alto ( 23,33 % ). La tasa de mortalidad global fue de 39,58 % ( 95/240 ), siendo mayor en los niveles de riesgo: Muy Alto 22,5% y Alto 13,8%. El análisis proporcional de riesgo de Cox mostró que la presencia en el momento de ingreso de Comorbilidad mayor (p=0,000), Transtorno del sensorio (p=0.000) y Shock séptico (p=0,000) se correlacionaron con una menor supervivencia y por tanto un mayor riesgo de mortalidad por sepsis. Finalmente se construyó la curva ROC, para el Meds Score total, observándose que en el presente estudio la prueba mantiene una buena capacidad discriminativa ( área bajo la curva ROC = 0.73), y por tanto el Meds score es una prueba válida en los pacientes estudiados. Conclusiones: El MEDS Score es una regla de alto valor predictivo de mortalidad por sepsis : que mantiene su nivel de validez en los pacientes del servicio de emergencia adultos del HNERM y que podría ser aplicado en los mismos
With the end to evaluate the MEDS score, in patient with sepsis or sepsis suspicion in the mature service of Emergency of the HNERM. and to determine the validity of this score in our means, we intended to be carried out the present study in 240 patients that completed the established inclusion approaches. Objectives: a) to Stratify by means of MEDS score, patient with sepsis or sepsis suspicion in different levels of risk. b) Conocer the frequency of mortalidad.por sepsis c) Determinar the correlation grade between the different levels of risk and their indexes of mortality. d) Proponer the application of adjusted guides of attention to the risk that you/they allow to improve the presage of the septic patients in the emergency service. Study type: Descriptive, prospective, longitudinal. Place: Mature service of Emergency of the HNERM. Methods and Results: The patients were stratified by means of MEDS score according to levels of risk of mortality: being obtained the following results: Very Low (10,00%), Lower (19,17%), Moderate (29,58%); High (17,92%) and Very High (23,33%). The rate of global mortality was of 39,58% (95 / 240); being bigger in the levels Very High 22,5% and High 13,8%. The proportional analysis of risk of Cox showed that the presence in the moment of entrance of more Comorbilidad (p=0,000), Transtorno of the sensory one (p=0.000) and septic Shock( p=0.00 ) was correlated with a smaller survival and therefore a bigger risk of mortality for sepsis. Finally the curve ROC was built, for the Meds total Score, being observed that presently study the test it maintains a good discriminatory capacity (area under the curve ROC = 0.73), and therefore the Meds score is a valid test in the studied patients. Conclusions: The MEDS Score is a rule of high value predictive of mortality for sepsis: that it maintains their level of validity in the patients of the mature emergency service of the HNERM and that it could be applied in the same ones
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Ulloa, Barbarán César Antonio, and Díaz Wendy Guisela Sotelo. "Valoración del índice de disfunción orgánica múltiple de Marshall en pacientes con sepsis en el Servicio de Emergencia del Hospital Nacional Dos de Mayo." Universidad Nacional Mayor de San Marcos. Programa Cybertesis PERÚ, 2004. http://www.cybertesis.edu.pe/sisbib/2004/ulloa_bc/html/index-frames.html.

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OBJETIVO: Determinar la valoración del Índice de Disfunción Orgánica Múltiple de Marshall en pacientes con sepsis en el Hospital Nacional 2 de Mayo. DISEÑO: Estudio prospectivo observacional con un diseño descriptivo longitudinal. LUGAR: Servicio de emergencia del Hospital Nacional 2 de Mayo. PACIENTES: Se evaluaron a 71 pacientes adultos con sepsis admitidos entre el 1 de julio al 31 de octubre del 2004 en el servicio de emergencia del Hospital Nacional 2 de Mayo. MEDIDAS Y RESULTADOS: Se encontró que de los 71 pacientes; 39 (54.9 %) fueron mujeres y 32 (45.1 %) fueron hombres; el foco séptico que más predominó fue el pulmonar con 42 casos que representa el 59.16 %, seguido por el foco dérmico con 11 casos. En cuanto al Índice de Disfunción Orgánica Múltiple (IDOM) se encontró que a partir del tercer día la elevación del mismo se correlacionó directamente con la mortalidad en forma altamente significativa (p<0.05), observándose un RR de 44.25, con una sensibilidad y especificidad del 90 % y 95 % respectivamente. CONCLUSIONES: Se evidenció que el poco difundido y poco aplicado Índice de Disfunción Orgánica Múltiple (IDOM) de Marshall sí tiene utilidad como instrumento de valoración, seguimiento y predicción de eventos adversos (fallecimiento) en pacientes sépticos (críticos), en relación a los demás scores (APACHE II, SOFA), por ser estos últimos de mayor complejidad en su aplicación y de necesitar mayor apoyo logístico.
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Books on the topic "Nosocomial Sepsis"

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Practices, LLC Best. Mapping patient flow to better manage severe hospital infections & sepsis. Chapel Hill, NC: Best Practices, 2004.

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Schapira, David V. The diagnosis and management of the cancer patient with sepsis. New York, NY: Biomedical Information Corp., 1986.

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Arthur, Baue, and Organ Failure Academy (Trieste, Italy), eds. Sepsis and organ dysfunction: Bad and good news on prevention and management. Milano: Springer, 2001.

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(Editor), Arthur E. Baue, G. Berlot (Editor), A. Gullo (Editor), and J. L. Vincent (Editor), eds. Sepsis and Organ Dysfunction: Bad and Good News on Prevention and Management. Springer-Verlag Telos, 2001.

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Török, M. Estée, Fiona J. Cooke, and Ed Moran. Fever. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0013.

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This chapter covers sepsis syndromes (characterized by systemic inflammation), pyrexia of unknown origin (including nosocomial pyrexia of unknown origin, immune-deficient pyrexia of unknown origin, and HIV-related pyrexia of unknown origin), imported fever or fever in returning travellers, and eosinophilia in returning travellers or migrants such as helminthic infections.
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Jolly, Elaine, Andrew Fry, and Afzal Chaudhry, eds. Infectious diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0012.

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Chapter 12 covers the basic science and clinical topics relating to infectious disease which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It begins with an overview, before covering diagnostic techniques, sepsis, antibiotics, needlestick injury, nosocomial infection, travel-related infection, immunocompromised hosts, pyrexia of unknown origin, infection in injecting drug users, bioterrorism, viral infection, HIV and AIDS, bacterial infections, mycobacterial infections, rickettsial infections, systemic fungal infections, protozoal infections, and helminthic infections.
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Book chapters on the topic "Nosocomial Sepsis"

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Bruderer, U., A. B. Lang, B. Byl, A. Crusiaux, and J. Deviere. "The Use of Antibody Specificity and Affinity in Determining the Protectiveness of Human Monoclonal Antibodies Against Fatal Infections with Nosocomial Gram-Negative Bacteria." In Host Defense Dysfunction in Trauma, Shock and Sepsis, 1223–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77405-8_158.

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M. Patil, Sachin, and Parag Patel. "Bactericidal and Bacteriostatic Antibiotics." In Infectious Diseases and Sepsis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99546.

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Of all the medications available to physicians worldwide, antibiotics play an essential role in inpatient and outpatient settings. Discovered in the early nineteenth century by Alexander Fleming, penicillin was the first antibiotic isolated from a mold. Dr. Gerhard Domagk developed synthetic sulfa drugs by altering the red dye used in chemical industries. Since then, multiple antibiotic classes have been discovered with varying antimicrobial effects enabling their use empirically or in specific clinical scenarios. Antibiotics with different mechanisms of action could be either bactericidal or bacteriostatic. However, no clinical significance has been observed between cidal and static antibiotics in multiple trials. Their presence has led to safer deep invasive surgeries, advanced chemotherapy in cancer, and organ transplantation. Indiscriminate usage of antibiotics has resulted in severe hospital-acquired infections, including nosocomial pneumonia, Clostridioides difficile infection, multidrug-resistant invasive bacterial infections, allergic reactions, and other significant side effects. Antibiotic stewardship is an essential process in the modern era to advocate judicial use of antibiotics for an appropriate duration. They play a vital role in medical and surgical intensive care units to address the various complications seen in these patients. Antibiotics are crucial in severe acute infections to improve overall mortality and morbidity.
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Conference papers on the topic "Nosocomial Sepsis"

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Vazquez, Cristina, Maria V. Dioverti Prono, Spiros Fortis, Hima Yalamanchili, Eleni Tiniakou, Victoria Salas, Spiros Chalkias, et al. "Timing Of Antibiotic Administration And Outcomes Of Patients With Nosocomial Sepsis." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4693.

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Rahi, M. S., K. Amoah, K. Gunasekaran, R. Kapil, and J. S. Kwon. "Elizabethkingia Meningoseptica sepsis Associated with COVID-19 Infection: An Emerging Nosocomial Pathogen." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2455.

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Colomer, B., G. Cotallo, and J. Sastre. "Nosocomial Sepsis in VLBW Neonates and Emergence of Antibiotic Resistance: An Epidemiological Study from the Spanish Neonatal Network “Grupo Castrillo”." In 7th International Conference on Clinical Neonatology—Selected Abstracts. Thieme Medical Publishers, 2018. http://dx.doi.org/10.1055/s-0038-1647090.

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Oliveira Neto, Marileide. "ELIZABETHKINGIA MENINGOSEPTICA E OS DESAFIOS NA IDENTIFICAÇÃO E TRATAMENTO: REVISÃO BIBLIOGRÁFICA." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1188.

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Introdução: Elizabethkingia meningoseptica é um bacilo Gram negativo frequentemente resistente a antibióticos prescritos para essa classe e está associado a meningite neonatal, sepse e infecções nosocomiais em pacientes imunocomprometidos. Objetivo: Evidenciar os desafios encontrados na identificação e tratamento de pacientes que apresentam infecções causadas por essa bactéria oportunista. Material e Métodos: A pesquisa aconteceu através de uma revisão bibliográfica da literatura, realizada no mês de abril de 2021. O levantamento de dados foi realizado nas bases de dados da SciELO, Medline e Lilacs no período compreendido entre 2010 e 2021. Resultados: Foram identificados inicialmente 51 artigos na literatura, destes 15 artigos foram selecionados para o trabalho. Os resultados apontaram: um aumento no número de casos por esse patógeno oportunista em pacientes imunocomprometidos em decorrência de equipamentos médicos, dispositivos medicamentosos e superfícies úmidas contaminadas; evidenciou também as dificuldades na identificação da E. meningoseptica, pois apesar de ser um bacilo Gram negativo não apresenta crescimento evidente em Agar MacConkey comumente utilizado para o crescimento de Gram negativas nos laboratórios de microbiologia, além disso possui genes de resistência para a maioria dos antibióticos prescritos para esse tipo de microrganismo e apresenta maior sensibilidade a antibióticos prescritos para bactérias Gram positivas; em relação ao tratamento todas as pesquisas analisadas demostraram que o uso combinado de alguns antibióticos são mais eficientes, como a vancomicina, ciprofloxacino, sulfametoxazol e trimetoprima. Conclusão: A presente revisão comprovou um aumento de casos de E. meningoseptica na última década, como também demonstrou a ausência de uma padronização para o tratamento das infecções causadas por esta bactéria, sendo que em muitos casos os tratamentos empíricos convencionais não são eficientes o que pode levar o paciente a óbito. Logo, constatou-se a grande necessidade de estudos e pesquisas que permitam identificar mais facilmente esses bacilos, pois isso é crucial no tratamento e maior probabilidade de recuperação do paciente.
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