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1

Ray, Pallab, Anindita Das, Vikas Gautam, Neetu Jain, J. D. Wig, and Meera Sharma. "POSTOPERATIVE NOSOCOMIAL ENTEROBACTER SAKAZAKII SEPSIS." ANZ Journal of Surgery 77, no. 10 (October 2007): 915–16. http://dx.doi.org/10.1111/j.1445-2197.2007.04276.x.

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2

Pellicone, M., H. C. Neu, N. X. Chin, M. Fracaro, J. Bissinger, and H. Bopp. "Nosocomial klebsiella sepsis following hemodialysis." American Journal of Infection Control 15, no. 2 (April 1987): 90. http://dx.doi.org/10.1016/0196-6553(87)90041-1.

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3

Yadav, Sunil Kumar, SP Yadav, P. Kanodia, N. K. Bhatta, R. R. Singh, and B. Khanal. "Nosocomial Sepsis and its Risk Factors: A Cross-Sectional Study in a Neonatal Intensive Care Unit." Journal of BP Koirala Institute of Health Sciences 2, no. 1 (July 24, 2019): 52–59. http://dx.doi.org/10.3126/jbpkihs.v2i1.24970.

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Introduction: Nosocomial sepsis is a common and serious infection of neonates who are admitted in intensive care unit. They lead to significant morbidity and mortality in both developed and resource limited countries. The neonatal intensive care unit (NICU) is a suitable environment for disseminating the infections and, hence, needs preventive intervention. The study was carried out to determine the risk factors for nosocomial sepsis in neonatal intensive care unit. Material and Methods: This was a cross-sectional study conducted in a seven bedded teaching and referral hospital NICU. All neonates in NICU who did not have any sign of infection at admission and remained hospitalized for at least 48 hours were observed. Nosocomial sepsis was diagnosed according to the CDC criteria. Risk factors for nosocomial sepsis were analyzed with Chi-square test and Logistic regression model. P-value of <0.05 was considered significant. Results: Low birth weight (both preterm and IUGR) and mechanical ventilation were found to be related with nosocomial sepsis. Conclusions: Low birth weight and mechanical ventilation were the most important risk factors fornosocomial sepsis.
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4

Snydman, David R. "Nosocomial Sepsis Associated with Interleukin-2." Annals of Internal Medicine 112, no. 2 (January 15, 1990): 102. http://dx.doi.org/10.7326/0003-4819-112-2-102.

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5

Kumar, Ashwani, and Praveen Kumar. "Nosocomial sepsis surveillance in the NICU." Journal of Neonatology 23, no. 1 (March 2009): 34–43. http://dx.doi.org/10.1177/0973217920090106.

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6

Auriti, Cinzia, Ersilia Fiscarelli, Maria Paola Ronchetti, Marta Argentieri, Gabriella Marrocco, Anna Quondamcarlo, Giulio Seganti, et al. "Procalcitonin in detecting neonatal nosocomial sepsis." Archives of Disease in Childhood - Fetal and Neonatal Edition 97, no. 5 (August 29, 2012): F368—F370. http://dx.doi.org/10.1136/fetalneonatal-2010-194100.

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7

Hugonnet, Stéphane, Hugo Sax, Philippe Eggimann, Jean-Claude Chevrolet, and Didier Pittet. "Nosocomial Bloodstream Infection and Clinical Sepsis." Emerging Infectious Diseases 10, no. 1 (January 2004): 76–81. http://dx.doi.org/10.3201/eid1001.030407.

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8

Hamory, Bruce H. "Nosocomial sepsis related to intravascular access." Critical Care Nursing Quarterly 11, no. 4 (March 1989): 58–65. http://dx.doi.org/10.1097/00002727-198903000-00007.

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9

Wood, M. J. "Chemotherapy for Gram-Positive Nosocomial Sepsis." Journal of Chemotherapy 11, no. 6 (December 1999): 446–52. http://dx.doi.org/10.1179/joc.1999.11.6.446.

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10

Heenen, Sarah, Frédérique Jacobs, and Jean-Louis Vincent. "Antibiotic strategies in severe nosocomial sepsis." Critical Care Medicine 40, no. 5 (May 2012): 1404–9. http://dx.doi.org/10.1097/ccm.0b013e3182416ecf.

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11

Segreti, John. "Nosocomial infections and Secondary Infections in Sepsis." Critical Care Clinics 5, no. 1 (January 1989): 177–89. http://dx.doi.org/10.1016/s0749-0704(18)30457-3.

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12

Shukla, Rakesh, Sushma Kaul, Vidya Gupta, Saroja Balan, and Anjali Kulkarni. "Nosocomial Sepsis: Prevention is the Best Cure." Journal of Neonatology 15, no. 4 (December 2001): 66–74. http://dx.doi.org/10.1177/0973217920010415.

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13

Atici, Aytuğg, Mehmet Satar, Aysun Karabay, and Mustafa Yilmaz. "Intravenous immunoglobulin for prophylaxis of nosocomial sepsis." Indian Journal of Pediatrics 63, no. 4 (July 1996): 517–21. http://dx.doi.org/10.1007/bf02905726.

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14

Young, Lowell S. "Ceftazidime in the treatment of nosocomial sepsis." American Journal of Medicine 79, no. 2 (August 1985): 89–95. http://dx.doi.org/10.1016/0002-9343(85)90267-0.

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15

Cabal, A., D. Schmid, S. Lepuschitz, A. Stöger, M. Blaschitz, F. Allerberger, W. Ruppitsch, and M. Hell. "Nosocomial outbreak of Streptococcus pyogenes puerperal sepsis." Clinical Microbiology and Infection 25, no. 4 (April 2019): 521–23. http://dx.doi.org/10.1016/j.cmi.2018.11.028.

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16

Nair, Vrinda, and Amuchou S. Soraisham. "Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants." International Journal of Pediatrics 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/874726.

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Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants.
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17

PRISACARI, Viorel, and Nicoleta ANDRONACHI. "Epidemiological study of Acinetobacter baumannii nosocomial infections." One Health & Risk Management 2, no. 2 (April 6, 2021): 36–41. http://dx.doi.org/10.38045/ohrm.2021.2.05.

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Introduction. Acinetobacter baumannii is a pathogen and a major cause of nosocomial infections in the current healthcare system worldwide due to its high resistance to antibiotics, including those considered as a last resort, thus posing threat to severe clinical forms, as well as exhibiting significant economic and clinical impact. Material and methods. A descriptive longitudinal and cross-sectional epidemiological study was carried out based on the model of multidisciplinary care hospitals. Results. The generalized clinical forms of Acinetobacter nosocomial infections predominate in 56.30%, including: pulmonary sepsis – 25.59%, abdominal sepsis – 11.81%, septicemia – 9.45%, wound sepsis– 6.30%, biliary sepsis – 1.97%, and urosepsis – 1.18% of cases. Local infections were found in 16.93% of wound infections and in 14.57% of pneumonia cases. A. baumanii was present in the etiological structure of 98.18% of cases, exhibiting an increased resistance to antibiotics, particularly to monobactams – 100.0%, macrolides – 98.82%, penicillins – 98.08%, cephalosporins – 97.65%, penicillins with beta-lactamase inhibitors – 93.20%, fluoroquinolones – 87.16%, and amphenicols – 84.17% of cases. A. baumanii strains isolated from patients with nosocomial infections were found to be multidrug resistant to antibiotics in 93.08% of cases. Conclusions. Acinetobacter baumannii nosocomial infections represent a major public health issue that requires the implementation of strict surveillance and control strategies, including the rational use of antibiotics.
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18

Fariñas-Álvarez, Concepción, M. Carmen Fariñas, Dolores Prieto, and Miguel Delgado-Rodríguez. "Applicability of Two Surgical-Site Infection Risk Indices to Risk of Sepsis in Surgical Patients." Infection Control & Hospital Epidemiology 21, no. 10 (October 2000): 633–38. http://dx.doi.org/10.1086/501705.

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AbstractObjective:To compare the ability of the Study of the Efficacy of Nosocomial Infection Control (SENIC) and the National Nosocomial Infection Surveillance (NNIS) indices to predict the development of nosocomial sepsis in subjects undergoing surgery.Design:1-year prospective case-control study.Setting:A tertiary-care center in Spain.Patients:Cases were surgical patients with nosocomial sepsis defined using the criteria of the Consensus Conference on Sepsis, identified by daily prospective surveillance.Methods:Controls were randomly selected from the daily list of surgical inpatients. Data were prospectively collected. To determine whether either index added explanatory information to the other, two methods were used. The first method involved computing a set of residuals for both variables. Residuals and primary variables were introduced in logistic regression models. The second method evaluated both indices with the Goodman-Kruskal (G) nonparametric coefficient.Results:99 cases and 97 controls were included. After controlling for confounders, both the SENIC index (P<.001) and the NNIS index (P=.04) showed a significant trend. Residuals of the SENIC index added discriminating ability to the NNIS index, whereas residuals of the NNIS index did not improve the prediction ability of the SENIC index. Similar results were yielded by the G statistic: the SENIC index showed higher predictive power than the NNIS index (G=0.56 vs G=0.41).Conclusions:Both indices performed about equally well for discriminating risk of nosocomial sepsis. The SENIC index had a somewhat better ability than the NNIS index only when the number of discharge diagnoses (not truly a predictive factor) were involved in the calculation of the SENIC index.
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19

Shorr, Andrew F., R. S. Johannes, Aaron D. Killian, Vikas Gupta, Larry Z. Liu, and Marin H. Kollef. "NOSOCOMIAL BACTEREMIA AND SEPSIS: EPIDEMIOLOGY, OUTCOMES, AND COST." Critical Care Medicine 32, Supplement (December 2004): A152. http://dx.doi.org/10.1097/00003246-200412001-00541.

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20

KOTLOFF, KAREN L., LILLIAN R. BLACKMON, JAMES H. TENNEY, MARGARET B. RENNELS, J. GLENN MORRIS, and Baltimore. "Nosocomial Sepsis in the Neonatal Intensive Care Unit." Southern Medical Journal 82, no. 6 (June 1989): 699–704. http://dx.doi.org/10.1097/00007611-198906000-00007.

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21

Mermel, L. A., and C. A. Spiegel. "Nosocomial Sepsis Due to Serratia odorifera Biovar 1." Clinical Infectious Diseases 14, no. 1 (January 1, 1992): 208–10. http://dx.doi.org/10.1093/clinids/14.1.208.

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22

Rajan, G., and J. W. Sleigh. "Lymphocyte counts and the development of nosocomial sepsis." Intensive Care Medicine 23, no. 11 (November 1997): 1187. http://dx.doi.org/10.1007/s001340050482.

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23

Asati, D. P., V. K. Sharma, S. Khandpur, G. C. Khilnani, and A. Kapil. "Clinicoetiological Study of Nosocomial Sepsis in Dermatology Ward." International Journal of Infectious Diseases 12 (December 2008): e353. http://dx.doi.org/10.1016/j.ijid.2008.05.940.

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24

Oliveira, Adriana Cristina, Andreza Werli, Adriana Oliveira Paula, Nelma Bras, and Stella Sala. "NOSOCOMIAL INFECTIONS IN A CLINICAL UNIT OF A STUDY HOSPITAL." Revista de Enfermagem UFPE on line 1, no. 2 (November 2, 2007): 220. http://dx.doi.org/10.5205/reuol.385-8818-1-le.0102200715.

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RESUMOA escassez de estudos relacionados ao diagnóstico das infecções hospitalares ou nosocomiais em unidades clínicas dificulta o conhecimento da magnitude do problema. Objetivou-se identificar a incidência das infecções hospitalares em uma unidade clínica de assistência a pacientes adultos, determinar os seus principais sítios, microrganismos relacionados e a taxa de óbito entre aqueles acometidos pela infecções hospitalares. Tratou-se de um estudo epidemiológico de abordagem quantitativa realizado em uma unidade de internação clínica de um hospital de universitário de dezembro de 2005 a junho de 2006. Avaliou-se 374 pacientes, notificando-se 106 infecções hospitalares [sepse laboratorialmente confirmada (21,7%), pneumonia (19,8%), infecção urinária assintomática (13,2%), sepse clínica (13,2%), infecção urinária sintomática (11,3%)], em 76 pacientes (28,3%). Registrou-se 47 óbitos, 18 (38,3%) após o diagnóstico da infecções hospitalares. O conhecimento das infecções hospitalares da unidade de estudo permite estabelecer parâmetros de comparação e estratégias de vigilância, aprimorando o cuidado em saúde para a instituição, o paciente e seus familiares.Descritores: Infecções; Incidência; Hospitalar; Vigilância epidemiológica; Unidade de internação; Cuidar em saúde. ABSTRACTThe scarcity of studies related to the diagnostic of nosocomial infections in clinical units makes it difficult to realize the magnitude of the problem. The object of this study was to identify the incidence of nosocomial infections in a clinical unit of assistance to adults patients, to determine the major sites of infection, the related microorganism and the death rate between those committed by nosocomial infection. It was a quantitative epidemiological study accomplished in a clinical internment unit of a university hospital from December 2005 to June 2006. 374 patients were evaluated, and 106 nosocomial infections were identified [sepse confirmed in laboratory (21,7%), pneumonia (19,8%), urinary tract infection (13,2%), clinic sepsis (13,2%), urinary tract symptomatic infection (11,3%)] in 76 patients. 47 deaths were registered, 18 (38,3%) after the diagnosis of nosocomial infection. The knowledge about the nosocomial infections in the unit of study make possible to establish parameters of comparison and surveillance strategies, improving the health care for the institution, to patients and their relatives.Descriptors: Infections; Incidence; Hospital: Epidemiological surveillance; Intensive care unit; Health care. RESUMENLa escasez de estudios relacionados al diagnostico de infecciones hospitalarias o nosocomiales en unidades clínicas, dificultan el conocimiento sobre la magnitud del problema. El objetivo de este trabajo fue identificar la incidencia de infecciones hospitalarias en una unidad clínica de asistencia a pacientes adultos, determinar los principales sitios de infección, los microorganismo relacionados y la tasa de mortalidad por infección hospitalaria. Fue un estudio epidemiológico, cuantitativo, realizado en una unidad de internación de un hospital universitario, entre diciembre del 2005 a junio del 2006. Fueron evaluados 374 pacientes y se identificaron 106 infecciones hospitalarias [sepsis confirmada en laboratorio (21,7%), neumonía (19,8%), infección urinaria asintomática (13,2%), sepsis clínica (13,2%), infección urinaria sintomática (11,3%)] en 76 pacientes. Fueron registrados 47 muertes, 18 (38,3%) después del diagnostico de infección hospitalaria. El conocimiento sobre las infecciones hospitalarias en la unidad clínica de estudio permite el establecimiento de parámetros de comparación y de estrategias de vigilancia, mejorando el cuidado de la salud en la institución, al pacientes y sus familiares.Descriptores: Infecciones; Incidencia; Hospitalar; Vigilancia epidemiológica; Unidad de internación; Cuidado en salud.
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Haque, Md Mozammel, Syeda Afroza, and Abid Hossain Mollah. "Efficacy of Probiotics to Reduce Nosocomial Infection and Feeding Intolerance in Hospitalized Low Birth Weight Babies." Journal of Bangladesh College of Physicians and Surgeons 36, no. 2 (May 10, 2018): 48–52. http://dx.doi.org/10.3329/jbcps.v36i2.36065.

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Background and objective: Neonatal sepsis is associated with increased mortality and morbidity of newborns. Moreover, inability to tolerate enteral feeding contributes to prolonged hospital stay and nosocomial sepsis. Probiotics confers health benefit to host by altering the gut environment. This study aimed at determining the efficacy of probiotics in reducing nosocomial sepsis and feeding intolerance in hospitalized low birth-weight infants.Methods: A quasi experimental clinical trial to compare between newborn infants getting probiotics along with breast milk (experimental group) with those getting breast milk only (non experimental group). Study was conducted from June to December 2013 with a total of 49 newborns, weighing 1000 to 2000gm.Results: In weight category 1000-1250 gm, 15.8% developed culture proven sepsis in probiotics/experimental group (n=9) and 10.5% in breast milk/non experimental group (n=10); p value was 0.655. Feeding intolerance was developed in 10.6% of the probiotics group and 31.5% of breast milk group, p value was not significant but the mortality was significantly lower among the probiotics group i.e., 5.3% in probiotics group Vs 42.1% in breast milk group (p 0.018). Between weight range of 1250-1500 gm, sepsis and feeding intolerance showed no significant differences (p value 0.305 & 0.305 respectively) but mortality differed significantly (0% probiotics group Vs 20% breast milk group; p 0.043). In weight range 1500-2000 gm, the result was not statistically significant for sepsis (p value 0.292), feeding intolerance (p value 0.292) and mortality (p value 0.292). Mortality was significantly lower in two weight categories (1000-1250 gm & 1250-1500 gm) and hence the overall result showed significant difference in the statistical analysis (p value 0.001).There were no differences either in nosocomial sepsis or feeding intolerance between the probiotics group and the breast milk group.Conclusion: Probiotics does not have any impact in reducing nosocomial infection and feeding intolerance but the use of probiotics seems to reduce mortality especially in the lower weight category.J Bangladesh Coll Phys Surg 2018; 36(2): 48-52
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26

Martínez-Aguilar, Gerardo, Celia M. Alpuche-Aranda, Carmen Anaya, Dolores Alcantar-Curiel, Catalina Gayosso, Carlos Daza, Cesar Mijares, Juan C. Tinoco, and Jose I. Santos. "Outbreak of Nosocomial Sepsis and Pneumonia in a Newborn Intensive Care Unit by Multiresistant Extended-Spectrum β-Lactamase-ProducingKlebsiella pneumoniaeHigh Impact on Mortality." Infection Control & Hospital Epidemiology 22, no. 11 (November 2001): 725–28. http://dx.doi.org/10.1017/s019594170007274x.

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AbstractWe describe a case-control study of a small outbreak of nosocomial sepsis and pneumonia with high mortality due to clonal dissemination of a multiresistantKlebsiella pneumoniaein the neonatal intensive care unit of a Mexican institution. Our study helped to change nosocomial infection control policy in this hospital.
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27

Martínez-Aguilar, Gerardo, Celia M. Alpuche-Aranda, Carmen Anaya, Dolores Alcantar-Curiel, Catalina Gayosso, Carlos Daza, Cesar Mijares, Juan C. Tinoco, and Jose I. Santos. "Outbreak of Nosocomial Sepsis and Pneumonia in a Newborn Intensive Care Unit by Multiresistant Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae High Impact on Mortality." Infection Control & Hospital Epidemiology 22, no. 11 (November 2001): 725–28. http://dx.doi.org/10.1086/501855.

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AbstractWe describe a case-control study of a small outbreak of nosocomial sepsis and pneumonia with high mortality due to clonal dissemination of a multiresistantKlebsiella pneumoniaein the neonatal intensive care unit of a Mexican institution. Our study helped to change nosocomial infection control policy in this hospital.
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28

Zaki, Maysaa E., Samah Bastawy, and Karim Montasser. "Molecular Study of E. coli Virulence Genes in Nosocomial Sepsis." Biosciences, Biotechnology Research Asia 16, no. 2 (May 27, 2019): 269–77. http://dx.doi.org/10.13005/bbra/2743.

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Escherichia coli (E. coli) is a common cause of nosocomial sepsis. There are multiple factors related to the severity of sepsis among these are the presence of virulence genes and the pattern of antibiotics resistance. The aim of the present study was to determine the prevalence of virulence pap gene encoding for pili, hlyA gene encoding for α-hemolysin and cnf1 gene encoding for cytotoxic necrotizing factor 1 among E. coli isolated from children with nosocomial sepsis. Also, to correlate the presence of ESBL and carbapenem resistance with the presence of these genes. The study is a retrospective cross-sectional study included 150 non-duplicate strains of E. coli isolated from blood cultures from children with nosocomial sepsis. The isolated E. coli strains were subjected to antibiotics study by disc diffusion method, detection of extended spectrum lactamase production by double discs diffusion method and determination of resistance to carbapenem by combined tests methods. The detection of virulence genes pap, hylA and cnf-1 were determined by multiplex polymerase chain reaction (PCR). E. coli isolates were classified as ESBL phenotype in 56% of the isolates and carbapenemase producing phenotype in 34.7%. Pap gene, hylA and cnf-1 genes were detected in 30%, 23.3% and 22.7% of the isolated E. coli. The clinic-laboratory study of the virulence genes of E. coli revealed the significant association of pap, hylA and cnf-1genes with prolonged duration of the use of the medical devices (4.3± 2.9 days-P=0.01, 4.5± 2.9 days, P=0.02, 5.2± 3.4 days, P=0.0001 respectively). HylA gene was associated with younger age of the patients (28.4± 4.5, P=0.01). Pap gene was significantly associated with ESBLs and carbapenemase phenotypes (P=0.0001, P=0.002 respectively). On the other hand, cnf-1 was significantly associated with E. coli isolated from primary sepsis (P=0.02) and in isolates from sepsis due to medical devices (P=0.02) and was significantly associated with death (P=0.01) and carbapenemase resistance (P=0.01). The present study highlights the prevalence of pap, hylA and cnf-1 virulence genes among E. coli associated with nosocomial sepsis in children. The frequency of some of these genes was correlated with extended spectrum lactamase resistance and carbapenemase resistance. This may be attributed to the presence of the virulence and antibiotics genes on transferable plasmids. Moreover, there was association with cnf-1 virulence gene and mortality outcome of sepsis. Further studies are recommended to evaluate these findings.
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Tattoli, Lucia, Alessandro Dell’Erba, Davide Ferorelli, Annarita Gasbarro, and Biagio Solarino. "Sepsis and Nosocomial Infections: The Role of Medico-Legal Experts in Italy." Antibiotics 8, no. 4 (October 28, 2019): 199. http://dx.doi.org/10.3390/antibiotics8040199.

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Sepsis is a leading cause of morbidity and mortality worldwide. It is defined as the presence of a Systemic Inflammatory Response Syndrome, and it represents a significant burden for the healthcare system. This is particularly true when it is diagnosed in the setting of nosocomial infections, which are usually a matter of concern with regard to medical liability being correlated with increasing economic costs and people’s loss of trust in healthcare. Hence, the Italian governance promotes the clinical risk management with the aim of improving the quality and safety of healthcare services. In this context, the role of medico-legal experts working in a hospital setting is fundamental for performing autopsy to diagnose sepsis and link it with possible nosocomial infections. On the other hand, medico-legal experts are party to the clinical risk management assessment, and deal with malpractice cases and therefore contribute to formulating clinical guidelines and procedures for improving patient safety and healthcare providers’ work practices. Due to this scenario, the authors here discuss the role of medico-legal experts in Italy, focusing on sepsis and nosocomial infections.
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30

Shiloni, Eitan. "Interleukin-2 Therapy, Central Venous Catheters, and Nosocomial Sepsis." Annals of Internal Medicine 112, no. 11 (June 1, 1990): 882. http://dx.doi.org/10.7326/0003-4819-112-11-882_3.

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Gozdas, Hasan Tahsin, Keziban Turken Gel, Aliye Yasayacak, Makbule Tokur Kesgin, and Hayrettin Akdeniz. "The role of hematological parameters in estimating nosocomial sepsis." Electronic Journal of General Medicine 16, no. 3 (May 16, 2019): em139. http://dx.doi.org/10.29333/ejgm/108678.

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32

Soltau, T. D., and R. L. Schelonka. "Immune Modification to Prevent Nosocomial Sepsis in Hospitalized Newborns." NeoReviews 9, no. 5 (May 1, 2008): e199-e205. http://dx.doi.org/10.1542/neo.9-5-e199.

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33

Clark, Reese, Richard Powers, Robert White, Barry Bloom, Pablo Sanchez, and Daniel K. Benjamin. "Prevention and Treatment of Nosocomial Sepsis in the NICU." Journal of Perinatology 24, no. 7 (May 6, 2004): 446–53. http://dx.doi.org/10.1038/sj.jp.7211125.

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34

Haugh, P. J., C. S. Levy, M. A. Smith, and D. K. Walshe. "Nosocomial Neisseria meningitidis Sepsis as a Complication of Plasmapheresis." Clinical Infectious Diseases 22, no. 6 (June 1, 1996): 1116–17. http://dx.doi.org/10.1093/clinids/22.6.1116.

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35

McKay, Victor J., Dan L. Stewart, Craig K. Steiner, and Larry N. Cook. "Nosocomial Sepsis During Extracorporeal Life Support (ECLS) ♦ 1326." Pediatric Research 41 (April 1997): 223. http://dx.doi.org/10.1203/00006450-199704001-01345.

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36

Bersani, I., and C. Speer. "Nosocomial Sepsis in Neonatal Intensive Care: Inevitable or Preventable?" Zeitschrift für Geburtshilfe und Neonatologie 216, no. 04 (August 2012): 186–90. http://dx.doi.org/10.1055/s-0032-1321837.

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37

Bhandari, Vineet, Leonard Eisenfeld, Trudy Lerer, Marlene Holman, and Jonelle Rowe. "Nosocomial sepsis in neonates with single lumen vascular catheters." Indian Journal of Pediatrics 64, no. 4 (July 1997): 529–35. http://dx.doi.org/10.1007/bf02737762.

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38

Gutierrez, Alejandro. "Miasis oral nosocomial en una unidad de cuidados intensivos." Anales de la Facultad de Medicina 80, no. 3 (October 10, 2019): 354–7. http://dx.doi.org/10.15381/anales.803.16860.

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Presentamos un caso de miasis nosocomial ocurrido en un hospital peruano, cuyo agente etiológico identificado fue Cochliomyia hominivorax, en un paciente de 82 años que estuvo internado en una unidad de cuidados intensivos por insuficiencia respiratoria aguda tipo I, y sepsis por absceso hepático, el cual fue sometido a intubación para brindarle respiración mecánica asistida. Al tercer día de ingreso a UCI se observó presencia de múltiples larvas maduras de tercer estadio en cavidad oral. El tratamiento consistió en la extracción manual de las larvas y terapia de ivermectina a razón de 0,2 miligramos por kilogramo de peso con respuesta favorable. Al mes de ser diagnosticado de miasis el paciente fallece por complicaciones de sepsis hepática y neumonía.
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39

Gajovic, Olgica, Predrag Canovic, Zeljko Mijailovic, and Zorica Lazic. "Nosocomial infections in patients with acute central nervous system infections." Medical review 60, no. 1-2 (2007): 12–18. http://dx.doi.org/10.2298/mpns0702012g.

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Due to current increase in the rate of nosocomial infections, our objective was to examine the frequency, risk factors, clinical presentation and etiology of nosocomial infections in patients with central nervous system infections. 2246 patients with central nervous system infections, treated in the intensive care units of the Institute of Infectious and Tropical Diseases, Clinical Center of Serbia in Belgrade and at the Department of Infectious Diseases of the Clinical Hospital Center Kragujevac, were included in this retrospective and prospective study. Clinical manifestations of nosocomial infections were registered in 180 (12.7%) patients. Direct risk factors for nosocomial infections were: venous lines, urinary catheter, length of stay over 20 days, inhibitors of gastric secretion, consciousness disorders and coma, endotracheal intubation, tracheotomy and controlled ventilation for 5 days or more. The most frequent clinical presentations of nosocomial infections were: tract urinary infections, bacteriemia/sepsis and nosocomial pneumonia. Significantly higher frequency of death outcomes was registered in patients with nosocomial infections.
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40

Malobicka, E., D. Roskova, V. Svihrova, and H. Hudeckova. "Point Prevalence Survey of Nosocomial Infections in University Hospital in Martin." Acta Medica Martiniana 13, no. 2 (November 1, 2013): 34–41. http://dx.doi.org/10.2478/acm-2013-0016.

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Abstract Nosocomial infections are a serious problem not only in Slovakia but in all countries. The European Commission decided on their standardized surveillance in the whole European Union. According methodology elaborated by experts from the European Centre for Disease Control and Prevention in Stockholm we performed a point prevalence survey in the University Hospital Martin. Our observed prevalence of nosocomial infections in University Hospital Martin within the point prevalence study was 5.2%. The highest point prevalence of nosocomial infections was found at the Surgical Department (9.3%). The most common type of nosocomial infections was urological infections (27.3%), sepsis (22.7%) and surgical site infection (22.7%). The most common microorganisms isolated from the biological material were Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Appropriate method of nosocomial infections surveillance is monitoring their prevalence in the point prevalence studies. International projects of nosocomial infections in the EU allow to compare the obtained results with other hospitals in the Member States.
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41

Tong, Dao-Ming, Ye-Ting Zhou, Shao-Dan Wang, Guang-Sheng Wang, and Xiao-Dong Chen. "Risk factors for nosocomial nontraumatic coma: sepsis and respiratory failure." Journal of Multidisciplinary Healthcare Volume 9 (September 2016): 463–68. http://dx.doi.org/10.2147/jmdh.s113682.

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42

Kidszun, A., L. Klein, A. Hansmann, J. Winter, B. Gröndahl, M. Knuf, K. Weise, and E. Mildenberger. "5ICCN_006: Viral infections in neonates with suspected nosocomial bacterial sepsis." Early Human Development 90 (September 2014): S63. http://dx.doi.org/10.1016/s0378-3782(14)50031-x.

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43

Fariñas-Álvarez, C., M. C. Fariñas, C. Fernández-Mazarrasa, J. Llorca, D. Casanova, and M. Delgado-Rodríguez. "Analysis of risk factors for nosocomial sepsis in surgical patients." British Journal of Surgery 87, no. 8 (August 1, 2000): 1076–81. http://dx.doi.org/10.1046/j.1365-2168.2000.01466.x.

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44

Kuzovlev, A., V. Moroz, and A. Goloubev. "Inhaled tobramycin for the treatment of nosocomial pneumonia in sepsis." Critical Care 18, Suppl 1 (2014): P360. http://dx.doi.org/10.1186/cc13550.

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45

Uknis, Marc E., and David L. Dunn. "Nosocomial infections and sepsis syndrome in critically ill surgical patients." Current Opinion in Critical Care 2, no. 4 (August 1996): 304–10. http://dx.doi.org/10.1097/00075198-199608000-00010.

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46

Pérez Solís, D., J. B. López Sastre, G. D. Coto Cotallo, M. ªA Diéguez Junquera, E. M. ª. Deschamps Mosquera, and M. Crespo Hernández. "Procalcitonina para el diagnóstico de sepsis neonatal de origen nosocomial." Anales de Pediatría 64, no. 4 (April 2006): 349–53. http://dx.doi.org/10.1157/13086523.

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47

Niederman, Michael S., and Alan M. Fein. "Sepsis Syndrome, the Adult Respiratory Distress Syndrome, and Nosocomial Pneumonia." Clinics in Chest Medicine 11, no. 4 (December 1990): 633–56. http://dx.doi.org/10.1016/s0272-5231(21)00760-7.

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48

Humphrey, Margaret A., George T. Simpson, and Gene A. Grindlinger. "Clinical Characteristics of Nosocomial Sinusitis." Annals of Otology, Rhinology & Laryngology 96, no. 6 (November 1987): 687–90. http://dx.doi.org/10.1177/000348948709600615.

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Paranasal sinusitis is an important source of sepsis and morbidity in head injury victims and requires aggressive pursuit and therapy. Of 208 head-injured patients, 24 developed paranasal sinusitis. The Glasgow Coma Scale score of the sinusitis patients was 7.1 ± 3.9. Nineteen patients were intubated nasotracheally, and five were intubated orally. Sinus air fluid levels, indicative of bleeding into the sinus, were seen on 17 initial computed tomographic scans. Maxillary sinus suppuration occurred in 23 patients; in 20 it was the initial sinus involved. Twenty-one patients developed polymicrobial sinusitis. Coexisting infections were common. In 15 patients with concurrent tracheobronchitis or pneumonia, organisms identical to those in sinus aspirations were recovered from the sputum. Seven patients had associated bacteremia. Meningitis in six patients shared a common pathogen with their sinusitis. Nonoperative management successfully resolved sinus infection in 19 cases. Five patients required open sinusotomy.
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Yaresko, V. G., S. O. Potalov, I. V. Filimonov, Y. O. Mikheev, and A. I. Marousi. "Microbial spectrum and rational antibacterial therapy in treatment of infected forms of necrotic pancreatitis." Modern medical technologies 41 part 1, no. 2 (April 6, 2019): 11–16. http://dx.doi.org/10.34287/mmt.2(41).2019.2.

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The most significant areas of scientific and practical research in urgent pancreatology of the last decade are the study of the course of necrotic pancreatitis with the evaluation of the effectiveness of antibiotic therapy at different stages of the disease according to microbiological studies, nosocomial infection and the development of sepsis. Purposw of the study. To study the effectiveness of antibacterial therapy in complex treatment of infected forms of necrotizing pancreatitis, depending on the species composition of the infection, the severity of the pathology and the development of sepsis. Materials and methods. The study included 48 patients with infected forms of necrotic pancreatitis over the past two years undergoing treatment at the Department of Anesthesiology and Intensive Care of Zaporizhzhia 3rd City Clinical Hospital in 2017–2018. Results. Research of the species composition of microorganisms showed that there is predominant gram-negative flora in pancreatogenic infection such as: Pseudomonas aeruginosa – 26,3%, Acinetobacter spp. – 21,1%, the Enterobacteriaceae family: Klebsiella pneumoniae – 10,5% and Escherichia coli – 15,8%. The detected spectrum of microorganisms gives an idea of the main pathogens characteristic of infected forms of necrotizing pancreatitis. Antibiotic sensibility analysis showed that high activity against pathogens was observed in meropenem, taygecycline and tobramycin. In 21% of patients, resistant strains of Ps. Aeruginosa were detected,but in 3 patients there was a positive dynamics in the use of detoxication therapy with inclusion of extracorporal methods (discrete plasmapheresis) in combination with two-component antibiotic therapy (meropenem + linezolid). Conclusion. The analysis of treatment of patients with infected necrotizing pancreatitis and its complication sonthebasis of continuous monitoring of bacterial flora with the provision of adequate antibiotic therapy, prevention of nosocominal infectionand a modern strategy for the use of surgical interventions, especiallynoninvasive, contributes to the reduction of sepsis and, as a result, reduction in mortality and severe postoperative complications. Keywords: necrotizing pancreatitis, combined antibiotic therapy, nosocomial infection, mortality.
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50

Valera, Mariangela, Carlo Scolfaro, Nazario Cappello, Elena Gramaglia, Sergio Grassitelli, Maria Teresa Abbate, Alberta Rizzo, et al. "Nosocomial Infections in Pediatric Cardiac Surgery, Italy." Infection Control & Hospital Epidemiology 22, no. 12 (December 2001): 771–75. http://dx.doi.org/10.1086/501861.

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AbstractObjective:To evaluate the incidence of nosocomial infection (NI) in pediatric patients who received cardiothoracic surgery and to identify possible associated risk factors.Design:Prospective observational study.Setting:The cardiac surgery and cardiac intensive care units at the Regina Margherita Children's Hospital, Turin, Italy.Patients:All patients who underwent surgery from July 20,1998, to July 19,1999, were enrolled, except patients with operative catheterization only.Methods:Clinical data were collected daily from July 20, 1998, to July 19, 1999. NIs were diagnosed according to US Centers for Disease Control and Prevention criteria.Results:104 patients were included in the present study, 80 (76.9%) of whom underwent extracorporeal circulation. The NI ratio was 48.1% (50/104); the percentage of patients with NI was 30.8% (32/104): 23.1% developed one infection, 7.7% two or more. The rate of NI was 2.17 per 100 days of hospitalization (50/2,304). The most common pathogen wasPseudomonas aeruginosa,Important risk factors were length of preoperative admission >5 days, total length of admission >10 days, open chest during postoperative phase, and cyanotic heart disease. There was a significant association between sepsis and central venous catheterization for 3 days or more. Rate of sepsis was 19 per 1,000 catheter days (16/852).Conclusion:NIs represent a frequent complication for children who undergo heart surgery. Based on our data, we suggest decreasing the preoperative stay as much as possible. The higher NI incidence in patients with an open chest postoperatively suggests that an alternative antibiotic strategy should be considered for these patients.
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