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Dissertations / Theses on the topic 'Novel Bile Acid Conjugates'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

CHINAGLIA, Nicola. "Design, synthesis and biological evaluation of novel nucleoside and oligonucleotide conjugates of bio-medical interest." Doctoral thesis, Università degli studi di Ferrara, 2019. http://hdl.handle.net/11392/2487947.

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Bioconjugation is the process of linking or connecting a biological molecule with another moiety. This moiety may include another biomolecule: in this case a hybrid is formed, in which the properties of the parent molecules are integrated, yielding a single entity with two different functions. With the aim to discover new nucleoside-based compounds of bio-medical interest, we consider bioconjugation as a powerful approach. In light of the well-known therapeutic potential of nucleosides as antitumorals and antivirals, in the first work reported in this thesis a conjugate between 2'-deoxyadenosi

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2

Trusova, Tatyana. "Quantitative estimation of bile acid conjugates in human bile using HPLC /." Connect to online version, 1995. http://hdl.handle.net/1989/3555.

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3

Hurley, J. P. "Novel bile acid-hydrogel systems as potential nedical device biomaterials." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269055.

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4

Tierney, Juliann Jude. "The synthesis and testing of novel cholic acid based stationary phases." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247854.

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5

Bhattacharya, Shiladitya. "Novel folate amphiphile conjugates for targeted drug delivery." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2360.

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Cancer is not only difficult to treat but the patients also suffer from the pain associated with anticancer treatments. Targeted chemotherapeutics can reduce the adverse effects by reducing the dose required for tumor cell kill. Cancers of various origins often have characteristic marker molecules that distinguish them from the normal tissues. Folate receptors are such marker molecules present in ovarian and cervical cancers. The hypothesis for the current study is that amphiphiles constructed out of folic acid, the natural ligand for the folate receptor, can deliver paclitaxel, a chemotherape

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6

Duncan, Kenneth William. "Development of a synthetic methodology towards novel bile acid and cholesterol analogues." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248838.

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7

Gopaul, Vedwatee Sashi. "The identification, characterization and profiling of novel thiol and amino acid conjugates of valproic acid in humans and animals." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0007/NQ34524.pdf.

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8

Trujillo, Jesse, та Jesse Trujillo. "A Novel Mechanism for Bile Acid Induced Activation of Estrogen Receptor β in Colorectal Cancer". Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/622961.

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Primary bile acids are a group of cholesterol metabolites that are synthesized in the liver and stored in the gallbladder. The main role of bile acids is to aid in the digestion of dietary fats and lipids. More recently, a signaling role for bile acids has been characterized. Secondary bile acids are formed when the bacteria of the colon metabolize primary bile acids. Secondary bile acids that escape enterohepatic re-uptake to the liver can have a deleterious effect in the colon. Deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) are two secondary bile acids that have been studied for thei

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9

Almarghalani, Daniyah Abduljalil. "Molecular Cloning, Expression, and Characterization of A Novel ZebrafishCytosolic Sulfotransferase, SULT5A1." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470097207.

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10

Delsol, Anne Aline Germaine. "Microbial 7-hydroxylation of the steroid lithocholic acid : a novel approach to produce bile acids for gallstone therapy." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297640.

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11

Fante, Cristina. "Synthesis and biological evaluation of a novel polyglutamic acid conjugates of dopamine and dopamine derivatives for the treatment of cancer." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553045.

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Polymer conjugation is a strategy able to enhance the tumour selectivity of anticancer drugs and to prolong their half life. Seventeen polymer-drug conjugates containing traditional chemotherapy (e.g. paclitaxel) have entered clinical trials and novel conjugates containing experimental drugs (e.g. the anti-angiogenic agent TNP-470) are emerging. Dopamine (DA) is an endogenous regulator of angiogenesis (the process of new blood vessels formation) and is able to retard the development of angiogenesis-dependent tumours when administered at a low non-toxic dose. However, the clinical application o

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12

Ramesh, K. "A Study of Supramolecular Gels and Self Assembly of Novel Bile Acid Conjugates." Thesis, 2013. http://etd.iisc.ernet.in/2005/3307.

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Chapter 1: Functional and Responsive Supramolecular Gels In this chapter ‘supramolecular gels’ derived from small organic molecules with molecular mass of typically less than 2000 daltons are discussed. Representative examples of various low molecular weight gelators based on their natural availability and also divergent functionalities are mentioned (Scheme 1). Scheme 1 Advances in the recent years have been very rapid in the field of supramolecular chemistry of gels giving rise to ‘Tunable responsive gels’. Control of the gel property in a reversible fashion has been the highlight of re

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13

Satyanarayana, T. B. N. "Design And Synthesis Of Bile Acid Derived Oligomers And Study Of Their Aggregation And Potential Applications." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2429.

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Chapter 1: Amphiphilic self-assembled systems as nanocarriers Nanocarriers are the nanometric size molecular assemblies that are used for the transport of small molecules into their non-solvating environments. These systems find major applications as drug delivery systems (DDS) in pharmacological research. These drug delivery systems improves solubility and stability of the drug molecules through encapsulation and also offer additional advantages like target specificity and stimuli responsive release of the drug molecules. Several types of DDS are reported in the literature, which can be prep

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14

Mohajeri, Sanaz. "A novel approach for the diagnosis of human hepatopancreatobiliary diseases: in vivo magnetic resonance spectroscopy of bile in one and two dimensions." 2014. http://hdl.handle.net/1993/23446.

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Bile is a biofluid synthesized by liver and concentrated in the gallbladder. Interference with the bile flow may cause cholestasis. Primary sclerosing cholangitis (PSC) is an inflammatory cholestatic disorder which eventually may result in liver cirrhosis and failure. The management of PSC is controversial. The only effective treatment for end stage disease is orthotopic liver transplantation (OLT). However, cholangiocarcinoma (CC), which is the major complication of this long-lasting disease, is an absolute contraindication for the surgery. Therefore, early diagnosis of the disease can not o

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15

Mukhopadhyay, Samrat. "Synthesis And Aggregation Behavior Of Novel Bile Acid Derivatives." Thesis, 2004. http://etd.iisc.ernet.in/handle/2005/1317.

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16

Nonappa, *. "Synthesis, Physicochemical Studies And Gelation Properties Of Novel Bile Acid Derivatives." Thesis, 2008. http://hdl.handle.net/2005/725.

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Chapter 1. An Overview of Bile Acid Science This chapter deals with an overview of bile acid science (cholanology) compiling elevant literature review, covering bile acid chemistry, biosynthesis, bile salt evolution, physiology and medicinal values. Figure 1. (a) Digestive system; (b) enterohepatic circulation and (c) cholic acid Bile acids are the end products of cholesterol metabolism, secreted in the liver and stored in the gall bladder (Figure 1). They are normally conjugated with glycine (75%) or taurine (25%). Because of their facially amphiphilic nature, bile salts tend to form

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17

Babu, P. "Synthesis And Physico-Chemical Properties Of Phosphonobile Acids : Novel Bile Acid Analogs." Thesis, 2004. http://etd.iisc.ernet.in/handle/2005/1314.

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18

Maity, Mitasree. "Bile Acid based Supramolecular Gels, Soft Hybrid Materials and their Applications." Thesis, 2016. http://hdl.handle.net/2005/2928.

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Chapter 1. Supramolecular Gels and their Applications Supramolecular gels are viscoelastic materials composed of a solid like three dimensional fibrillary network that is embedded in a liquid. Supramolecular gels are derived from low molecular weight compounds (typically MW < 3000). In the 1990s, the investigations on gels were mainly focused on designing new gelator molecules. However, during the last decade, research focus shifted towards designing functional gels and their applications. As a result of extensive work in this area, gels have been found to have varied applications in the templ

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19

"Structural Characterization of a Novel Mouse 7帢-Hydroxyl Bile Acid-preferring Cytosolic Sulfotransferase (mL-STL)". 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292446.

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