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Journal articles on the topic 'Novel Formulations'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

García-Sánchez, José Manuel, and Plácido Moreno. "Novel Approaches to the Formulation of Scheduling Problems." Mathematics 12, no. 7 (2024): 1035. http://dx.doi.org/10.3390/math12071035.

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This paper presents two novel formulations for scheduling problems, namely order-position hybrid formulation (OPH) and order-disjunctive hybrid formulation (ODH), which extend and combine parts of existing formulation strategies. The first strategy (OPH) is based on sequence position and linear ordering formulations, adding relationships between constraints that allow relaxing some decision variables. The second approach (ODH) is based on linear ordering and disjunctive formulations. In this work, we prove ODH to be the most efficient formulation known so far. The experiments have been carried

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Akiro F., Tugonza. "Engineering Novel Drug Formulations: Challenges and Opportunities." NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY 6, no. 1 (2025): 20–26. https://doi.org/10.59298/nijpp/2025/612026.

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The development of novel drug formulations is a crucial aspect of pharmaceutical research, ensuring enhanced drug efficacy, bioavailability, and patient compliance. Despite significant advancements, challenges such as poor solubility, stability issues, and regulatory constraints continue to hinder the formulation of new drugs. This paper examines fundamental concepts in drug formulation, highlighting the limitations of conventional approaches and the emergence of advanced technologies, including nanotechnology-based formulations. Innovations in targeted delivery systems and the integration of

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YAVUZ, Akif, and Osman Taha SEN. "Novel approaches to assessing brake squeal propensity: comparative evaluation of two index formulations." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 270, no. 4 (2024): 7362–69. http://dx.doi.org/10.3397/in_2024_3952.

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The persistence of brake squeal as a significant NVH issue within automotive brake systems necessitates the development of robust methods for assessing squeal propensity. This study introduces two novel squeal index formulations for assessment purposes and evaluates their performance against the formulation defined by the SAE J2521 standard. Experimental data essential for formulating the squeal index are collected on a controlled mass-sliding belt experiment. Experiments are performed at three different spring stiffness levels, and squeal index formulations are derived based on time and frequ

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Pandey, Prateek, Anil Sharma, Hariom Sharma, Girish Kumar Vyas, and Manmohan Sharma. "Novel Researched Herbal Sunscreen Cream SPF Determination by In-Vitro Model." Asian Journal of Pharmaceutical Research and Development 11, no. 2 (2023): 83–90. http://dx.doi.org/10.22270/ajprd.v11i2.1246.

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INTRODUCTION: Researchers' interest in creating novel cosmetic formulations has increased due to consumer interest in herbal cosmetics and increased patent activity. The rights of indigenous traditional knowledge and benefit sharing are also safeguarded under IPR. OBJECTIVE: To formulate and evaluate herbal sunscreen with determination of Sun Protection Factor (SPF) and anti-oxidant activity. To compare Sun Protection Factor of developed formulation with marketed formulation. METHOD: The formulation was developed according to the prepared formula. And multiple tests were done for e

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Owen, R. T. "Novel zolpidem formulations." Drugs of Today 45, no. 5 (2009): 395. http://dx.doi.org/10.1358/dot.2009.45.5.1377599.

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Owen, R. T. "Novel zolpidem formulations." Drugs of Today 45, no. 5 (2009): 395. http://dx.doi.org/10.1358/dot.2009.45.5.1370457.

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Mishra, Ashwani, and A. K. Pathak. "Plasticizers: A Vital Excipient in Novel Pharmaceutical Formulations." Current Research in Pharmaceutical Sciences 7, no. 1 (2017): 01–10. http://dx.doi.org/10.24092/crps.2017.070101.

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Melissa, R. Cardoz*and Padmini Ravikumar. "DESIGN, DEVELOPMENT AND EVALUATION OF NOVEL ORAL MEDICATED JELLIES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1746–54. https://doi.org/10.5281/zenodo.823242.

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Ranitidine Hydrochloride has a very bitter taste. The bitter taste of the drug makes administration of the dosage form difficult, especially to paediatric patients. Oral medicated jellies are novel drug delivery systems overcoming these problems. They are sucrose based formulation thus providing higher compliance. These formulations are also advantageous for geriatric and dysphagic patents. Natural polymers used in jelly formulation are biodegradable, biocompatible, nontoxic, low cost and environment friendly, locally available, better patient tolerated and edible. The aim was to develop and e

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Florence, Alexander T., and Praful U. Jani. "Novel Oral Drug Formulations." Drug Safety 10, no. 3 (1994): 233–66. http://dx.doi.org/10.2165/00002018-199410030-00005.

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Chorachoo, Julalak, Thanaporn Amnuaikit, and Supayang P. Voravuthikunchai. "Liposomal Encapsulated Rhodomyrtone: A Novel Antiacne Drug." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/157635.

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Rhodomyrtone isolated from the leaves ofRhodomyrtus tomentosapossesses antibacterial, anti-inflammatory, and anti-oxidant activities. Since rhodomyrtone is insoluble in water, it is rather difficult to get to the target sites in human body. Liposome exhibited ability to entrap both hydrophilic and hydrophobic compounds and easily penetrate to the target site. The present study aimed to develop a novel liposomal encapsulated rhodomyrtone formulations. In addition, characterization of liposome, stability profiles, and their antiacne activity were performed. Three different formulations of total

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Dedeloudi, Aikaterini, Angeliki Siamidi, Panagoula Pavlou, and Marilena Vlachou. "Recent Advances in the Excipients Used in Modified Release Vaginal Formulations." Materials 15, no. 1 (2022): 327. http://dx.doi.org/10.3390/ma15010327.

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The formulation of an ideal vaginal drug delivery system (DDS), with the requisite properties, with respect to safety, efficacy, patient compliance, aesthetics, harmonization with the regulatory requirements, and cost, requires a meticulous selection of the active ingredients and the excipients used. Novel excipients defined by diversity and multifunctionality are used in order to ameliorate drug delivery attributes. Synthetic and natural polymers are broadly used in pharmaceutical vaginal formulations (solid, semi-solid dosage forms, implantable devices, and nanomedicines) with a promising pe

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Kanchan, Jamkar* Ashwini Pande Shital Mule Vinayak Pitale Ravi kute. "Formulation And Evaluation Of A Novel Polyherbal Shampoo." International Journal of Pharmaceutical Sciences 2, no. 9 (2024): 1301–10. https://doi.org/10.5281/zenodo.13838061.

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This study presents the formulation and evaluation of a novel polyherbal shampoo designed to leverage the beneficial properties of various natural ingredients. A total of three formulations were developed using the decoction method, incorporating key herbal components such as Hibiscus, Neem, Amla, Aloe Vera, and Shikakai. Each formulation underwent comprehensive physicochemical evaluations, including assessments of physical appearance, pH, solid content, foaming ability, foam stability, dirt dispersion, skin sensitization, and stability studies. The results revealed that all formulations exhib

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Baboota, Sanjula, Faiyaz Shakeel, Alka Ahuja, Javed Ali, and Sheikh Shafiq. "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib." Acta Pharmaceutica 57, no. 3 (2007): 315–32. http://dx.doi.org/10.2478/v10007-007-0025-5.

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Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxibThe aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). Thein vitroskin permeation profile of optimized formulations was compared with CXB gel and nanoemulsion gel. Significant increase in the steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) was observed in nanoemulsion formulations T1 and T2 (p< 0.05). The highest value of these permeability parameters was obtained in form

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Omer, Mustafa E., Majed Halwani, Rayan M. Alenazi, et al. "Novel Self-Assembled Polycaprolactone–Lipid Hybrid Nanoparticles Enhance the Antibacterial Activity of Ciprofloxacin." SLAS TECHNOLOGY: Translating Life Sciences Innovation 25, no. 6 (2020): 598–607. http://dx.doi.org/10.1177/2472630320943126.

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Ciprofloxacin (CIP), a widely used antibiotic, is a poor biopharmaceutical resulting in low bioavailability. We optimized a CIP polymer–lipid hybrid nanoparticle (CIP-PLN) delivery system to enhance its biopharmaceutical attributes and the overall therapeutic performance. CIP-PLN formulations were prepared by a direct emulsification–solvent–evaporation method. Varying the type and ratio of lipid was tried to optimize a CIP-PLN formulation. All the prepared formulations were evaluated for their particle size, polydispersity index, zeta potential, physical stability, and drug entrapment efficien

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Rahim, Haroon, Mir Azam Khan, Amin Badshah, Kamran Ahmad Chishti, Salimullah Khan, and Muhammad Junaid. "Evaluation of Prunus domestica gum as a novel tablet binder." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (2014): 195–202. http://dx.doi.org/10.1590/s1984-82502011000100020.

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To evaluate binding potential of Prunus domestica gum in tablets formulations. Six tablet batches (F-1B to F-6B) were prepared by wet granulation method, containing Avicel pH 101 as diluent, sodium diclofenac as model drug using 10, 15 and 20 mg of Prunus domestica gum as binder and PVP K30 was used as standard binder. Magnesium stearate was used as lubricant. Flow properties of granules like bulk density, tapped density, Carr index, Hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets including hardness, friability, thickness and disintegration time were d

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Neeraj, Soni Neha Rathore Shweta Kumari Shruti Rathore. "Formulation And Development of Novel Microemulsion Of Acyclovir." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 703–10. https://doi.org/10.5281/zenodo.14169580.

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The aim of this study was to enhance the permeability of acyclovir (ACV) by formulating a water-in-oil microemulsion. Permeability plays a crucial role in the oral absorption and bioavailability of drugs. The microemulsion (ME) was characterized using droplet size analysis, dilution test, zeta potential measurement, in vitro drug permeation study, and in vivo study. The optimized formulation, which demonstrated the highest ACV incorporation (81.57 mg/ml), comprised 13.3% Polysorbate 80, 13.3% ethanol, 6.6% ginger oil, and 66% water. The droplet size analysis indicated optimal results, and othe

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Khobragade, Deepak S., K. Vighneshwar, and Mrunali S. Potbhare. "Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for Extended Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1219–27. http://dx.doi.org/10.25258/ijddt.12.3.49.

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Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed formulate and evaluate the prolonged-release compressed multiple-unit pellet system of Metoprolol succinate. MUPS are novel formulations with benefits of both single and multi unit dosage forms and can provide extended drug delivery release profile and increase the efficiency profile of the drug. Metaprolol su

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Prasad, Kate*1 Vilas Sawale Rajanikant Kakade3 Runita Karale4 Teena Dubey5. "Novel Herbal Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 10–20. https://doi.org/10.5281/zenodo.11409656.

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Proactive and plant selections have been used to create innovative herbal formulations, including polymeric nanoparticles, nanocapsules, liposomes, phytosomes, animations, microspheres, transfersomes, and ectosomes’. The novel formulations of plant actives and extracts are reported to have outstanding benefits over traditional formulations. These benefits include increased solubility, bioavailability, and toxicity protection; improved tissue macrophage distribution; sustained delivery; enhanced pharmacological activity; and protection against physical and chemical degradation. A well-kno

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Doe, Jane A. "A NOVEL PRECIPITATION METHOD FOR SOLIDIFYING THERAPEUTIC MONOCLONAL ANTIBODIES: A COST-EFFECTIVE ALTERNATIVE TO LYOPHILIZATION." Critique Open Research & Review 03, no. 02 (2025): 1–6. https://doi.org/10.55640/corr-v03i02-01.

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Therapeutic monoclonal antibodies (mAbs) have become integral in the treatment of various diseases, but their formulation and stability remain challenges for long-term storage and distribution. Traditionally, lyophilization (freeze-drying) is employed to convert mAbs into solid formulations; however, this process is time-consuming, costly, and can lead to protein instability. In contrast, a precipitation-based process offers a potential alternative for generating solid mAb formulations. This study explores the use of ammonium sulfate as a precipitating agent to solidify monoclonal antibodies w

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Gautam, Manish. "Management of epidermal hyperpigmentation with a novel depigmenting formulation: a research survey." International Journal of Research in Medical Sciences 11, no. 9 (2023): 3365–72. http://dx.doi.org/10.18203/2320-6012.ijrms20232794.

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Background: Epidermal hyperpigmentation is an important dermatological concern with a high prevalence in the Indian population. Kojic acid-based depigmenting formulations have proven to be effective in the management of epidermal hyperpigmentation. A questionnaire-based survey was conducted to assess physicians’ knowledge about epidermal hyperpigmentation and practice patterns about a novel depigmenting formulation containing a combination of kojic acid dipalmitate 4%, azelaic acid 12%, glycolic acid 3%, niacinamide 4%, arbutin 2%, glycogen liquid 2%, sodium hyaluronate solution 2%, and shea b

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Patel, Deep. "A Comparative Study on Applications of Novel Drug Delivery System for Herbal Formulations." International Journal for Research in Applied Science and Engineering Technology 9, no. VIII (2021): 27–31. http://dx.doi.org/10.22214/ijraset.2021.37263.

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For plant actives and extracts, novel drug delivery systems (NDDS) have made great strides in the past few years. Bioactive and plant extracts have been used to create a variety of novel herbal formulations, including polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microspheres, transferosomes, and ethosomes. There are a number of advantages that the novel formulations have over conventional formulations, including improved solubility, bioavailability, protection from toxicity, enhancement of pharmacological activity, improved tissue distribution of macrophages, su

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Tan, Zhi Ming, Gui Ping Lai, Manisha Pandey, et al. "Novel Approaches for the Treatment of Pulmonary Tuberculosis." Pharmaceutics 12, no. 12 (2020): 1196. http://dx.doi.org/10.3390/pharmaceutics12121196.

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Tuberculosis (TB) is a contagious airborne disease caused by Mycobacterium tuberculosis, which primarily affects human lungs. The progression of drug-susceptible TB to drug-resistant strains, MDR-TB and XDR-TB, has become worldwide challenge in eliminating TB. The limitations of conventional TB treatment including frequent dosing and prolonged treatment, which results in patient’s noncompliance to the treatment because of treatment-related adverse effects. The non-invasive pulmonary drug administration provides the advantages of targeted-site delivery and avoids first-pass metabolism, which re

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Soyka, Michael. "Novel Long-Acting Buprenorphine Medications for Opioid Dependence: Current Update." Pharmacopsychiatry 54, no. 01 (2020): 18–22. http://dx.doi.org/10.1055/a-1298-4508.

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AbstractOpioid maintenance treatment with oral methadone or sublingual buprenorphine is the first-line treatment in opioid dependence. Three novel long-acting buprenorphine formulations have been approved or will be available soon: for subcutaneous weekly and monthly application, the depot formulations CAM 2038 (Buvidal®), the monthly depot formulation RBP-6000 (Sublocade™), and a 6-month buprenorphine implant (Probuphine™). Clinical data available so far on the efficacy of these 3 medications are given, and possible clinical implications are discussed.

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Rani, Nisha, Dhruv Dev, and D. N. Prasad. "Recent Trends in developments of Superdisintegrants: An Overview." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 163–69. http://dx.doi.org/10.22270/jddt.v12i1.5148.

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Fast dissolving tablets are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without using water. To provide this type of character in a dosage form, different excipients are required. Superdisintegrants are a class of novel agents that have emerged in recent years. Improving drug bioavailability in the pharmaceutical field is a challenge. The inclusion of superdisintegrants in the formulation enhances the formulation's efficacy. The main goal of this review article is to highlight current development in the superdisintegrants. Novel medication delivery techniques hav

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Robaina, Diego M., Silvana Alvariza, and Gonzalo Suárez. "Bioequivalence of two novel formulations of ivermectin 1% combined with fluazuron 12.5% for subcutaneous administration in cattle." Journal of Pharmacy & Pharmacognosy Research 9, no. 1 (2021): 88–97. http://dx.doi.org/10.56499/jppres20.955_9.1.88.

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Context: Ivermectin (IVM) and fluazuron are present as novel combinations to control ticks. Differences in formulations account for changes to the plasma kinetics and could change exposure of target parasites to active drugs. Aims: To evaluate bioequivalence for ivermectin administered by two novel formulations combined with fluazuron. Methods: Twelve male Holstein calves were randomized into two groups (n=6), receiving a single subcutaneous dose of a novel formulation (A or B) of ivermectin combined with fluazuron (ivermectin 1% 0.2 mg/kg + fluazuron 12.5% 2.5 mg/kg). Blood samples were taken

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Carmona-Ribeiro, Ana, and Letícia de Melo Carrasco. "Novel Formulations for Antimicrobial Peptides." International Journal of Molecular Sciences 15, no. 10 (2014): 18040–83. http://dx.doi.org/10.3390/ijms151018040.

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Sivapriya, V., S. Ponnarmadha, N. Abdul Azeezand, and V. Sudarshanadeepa. "NOVEL NANOCARRIERS FOR ETHNOPHARMACOLOGICAL FORMULATIONS." International Journal of Applied Pharmaceutics 10, no. 4 (2018): 26. http://dx.doi.org/10.22159/ijap.2018v10i4.26081.

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A numerous novel drug delivery system has been emerged by combining herbal medicine with nanotechnology to administer drugs encompassing the enhancement of compatibility and efficacy. The herbal phytoconstituents are compatible compared to the chemical active pharmaceutical ingredients (APIs). But the therapeutic consequence of the phytoconstituent is limited due to poor aqueous solubility. Therefore, the demand to develop a system which improves the solubility of the phytomedicine is mounting rapidly. Nanotechnology plays a vital role in increasing the solubility, enhancing the bioavailabilit

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Neacșu, Sorinel Marius, Magdalena Mititelu, Emma Adriana Ozon, et al. "Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties." Pharmaceuticals 17, no. 6 (2024): 690. http://dx.doi.org/10.3390/ph17060690.

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(1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes, highlighting the pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop and characterise two novel antioxidant formulations, F3 and F4, as therapeutic interventions for oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation of filling powders for capsules, capsule content evaluation, and

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Özakın, Süleyman. "pH effect on paraben stability for parenteral drug formulation." Journal of Research in Pharmacy 29, no. 1 (2025): 280–86. https://doi.org/10.12991/jrespharm.1643757.

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The pH optimization and EDTA are widely used in pharmaceutical formulations. The aim of the research work was to evaluate the pH effect and develop a including stable paraben pharmaceutical product. pH of final product is most important critical quality attributes (CQA). Variability pH of formulation is affecting paraben stability. Therefore, chemical stability may affect paraben assay, so this CQA was be evaluated throughout parenteral formulation. A total of four formulations were designed to the stability study. To improve the stability of paraben formulations (T1-T4) were evaluated with di

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Bhaskarrao, Pande V., Chandel S. Singh, and Soni Vishal. "Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1612–17. http://dx.doi.org/10.25258/ijddt.12.4.23.

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Worldwide demand for new anti-diabetic drugs from plant sources has increased as diabetes mellitus has become a global epidemic. In the era of herbal medicines, polyherbal formulations offer higher therapeutic efficacy than single plants due to synergistic effects. Therefore, the objective was to develop a novel anti-diabetic polyherbal formulation containing mixtures of three plants: Azadirachta indica leaves, Tinospora cordifolia stem and Ocimum sanctum leaves extracts. The eight different plant formulations (F1 to F8) were formulated while F1 to F3 contained a single plant extract. Hypergly

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Madhavi, Nupur, Dharmender Kumar, Subh Naman, et al. "Formulation and Evaluation of Novel Herbal Formulations Incorporated with Amla Extract for Improved Stability." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 212–21. http://dx.doi.org/10.22270/jddt.v9i4.3029.

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The objective of the present study was to formulate effervescent and fast dispersible granules by incorporating the fruit extract of Emblica officinalis as an alternate of liquid herbal juices available in market. Amla juice was extracted manually and then subjected to preliminary phytochemical screening which indicates the presence of alkaloids, glycosides, flavonoids, carbohydrates, phenolic compounds, proteins and phytosterols. Lyophilized amla powder was used to formulate effervescent and fast dispersible granules which were further optimized on the basis of concentration of superdisintegr

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Helal, Nada A., Heba A. Eassa, Ahmed M. Amer, Mohamed A. Eltokhy, Ivan Edafiogho, and Mohamed I. Nounou. "Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved." Recent Patents on Drug Delivery & Formulation 13, no. 2 (2019): 105–56. http://dx.doi.org/10.2174/1872211313666190503112040.

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: Traditional nutraceuticals and cosmeceuticals hold pragmatic nature with respect to their definitions, claims, purposes and marketing strategies. Their definitions are not well established worldwide. They also have different regulatory definitions and registration regulatory processes in different parts of the world. Global prevalence of nutraceuticals and cosmeceuticals is noticeably high with large market share with minimal regulation compared to traditional drugs. The global market is flooded with nutraceuticals and cosmeceuticals claiming to be of natural origin and sold with a therapeut

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Nakka, Samantha A. Jayasree Praneetha. D. *. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE." Journal of Scientific Research in Pharmacy 09, no. 08 (2020): 13–18. https://doi.org/10.5281/zenodo.7626012.

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<strong><em>ABSTRACT</em></strong> <strong> Recent advances in novel drug delivery aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. One such approach is oral disintegrating tablets. Oro-dispersible tablets are a suitable means of drug delivery system for better patient compliance, rapid onset of action, increased bioavailability. The purpose of the present research was to formulate and evaluate the mouth disintegrating tablets of metoclopramide hydrochloride. Metoclopramide

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M, Sindhoor S., Sneh Priya, and Amala Maxwell. "FORMULATION AND EVALUATION OF NOVEL IN SITU GEL OF LAFUTIDINE FOR GASTRO RETENTIVE DRUG DELIVERY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 88. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25582.

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Objective: The aim of the present study was to formulate and evaluate the novel in situ gel of lafutidine for gastroretentive drug deliveryMethods: A gastroretentive in situ gel of lafutidine was formulated by pH-triggered ionic gelation method using different concentrations of gelling polymer such as sodium alginate, gellan gum, and xanthum gum. Prepared formulations were evaluated for viscosity, density, buoyancy lag time and buoyancy duration, and drug content. In vitro drug release studies of all formulations were also performed. In vivo fluorescence imaging study was conducted for optimiz

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Yukti, Mahajan* Dev Raj Sharma Pravin Kumar Mahender Singh Ashawat. "Natural Polymers as Excipient in Formulation of Novel Drug Delivery System." Int. J. in Pharm. Sci. 1, no. 8 (2023): 50–71. https://doi.org/10.5281/zenodo.8229107.

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The therapeutic formulation has two main components which are active pharmaceutical ingredients and excipients to support into the production process in addition to enhancing medication distribution. In manufacturing dosage forms, to improve physicochemical parameters and to improve the stability of the dosage form excipients have proven to be very helpful. Excipients are currently utilized in novel drug delivery technology to fulfil customized functions, and in some cases, they directly or indirectly influence the extent and rate of drug release and effectiveness. Advances in polymer science

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Sarma, Himangshu, Taslima Jahan, Ashis Kumar Goswami, and Hemanta Kumar Sharma. "An Experimental investigation based on a Novel Gastro-Retentive Raft Liquid Dosage Form in Tandem with Controlled-Release Strategies for Oral Delivery of Metronidazole." Fabad Journal of Pharmaceutical Sciences 50, no. 1 (2025): 95–110. https://doi.org/10.55262/fabadeczacilik.1573673.

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Background: Peptic ulcers are open sores that develop on the inner lining of the stomach and duodenum. The most common inducer of peptic ulcers includes Helicobacter pylori as the primary pathogen. The present study aimed to design and develop a novel gastro-retentive raft liquid dosage formulation to prolong the gastric retention time of the medicament to treat H. pylori infection. Methods: Metronidazole-loaded raft formulations were prepared using ion-sensitive in situ gel-forming polymers. The formulation was floated within 1 minute on the liquid surface of the in vitro model and maintained

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Holmbäck, Jan, Vibhu Rinwa, Tobias Halthur, Puneet Rinwa, Anders Carlsson, and Bengt Herslöf. "AKVANO®: A Novel Lipid Formulation System for Topical Drug Delivery—In Vitro Studies." Pharmaceutics 14, no. 4 (2022): 794. http://dx.doi.org/10.3390/pharmaceutics14040794.

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A novel formulation technology called AKVANO® has been developed with the aim to provide a tuneable and versatile drug delivery system for topical administration. The vehicle is based on a water-free lipid formulation where selected lipids, mainly phospholipids rich in phosphatidylcholine, are dissolved in a volatile solvent, such as ethanol. With the aim of describing the basic properties of the system, the following physicochemical methods were used: viscometry, dynamic light scattering, NMR diffusometry, and atomic force microscopy. AKVANO formulations are non-viscous, with virtually no or

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Pasca, Paula Melania, Florina Miere (Groza), Angela Antonescu, et al. "Novel Liposomal Formulation with Azelaic Acid: Preparation, Characterization, and Evaluation of Biological Properties." Applied Sciences 12, no. 24 (2022): 13039. http://dx.doi.org/10.3390/app122413039.

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Azelaic acid (AA), as a natural product, was proven to be effective in targeting multiple causes of acne and related dermatological conditions, as it is well tolerated using different classical formulations (gel, cream, etc.). However, its limited aqueous solubility and inadequate penetration across the stratum corneum might be related to different possible side effects such as itching and burning. The aim of our work was to elaborate a novel liposomal formulation based on azelaic acid, with enhanced biocompatibility, bio-availability, antimicrobial, antigenotoxic, and anti-inflammatory proper

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Pandey, Garima, Surendra Dangi, and Bhaskar Kumar Gupta. "Design, Development and Characterization of Novel Ranitidine-Loaded Mucoadhesive Delivery System." International Journal of Medical & Pharmaceutical Sciences 14, no. 05 (2024): 01–10. https://doi.org/10.31782/ijmps.2024.14501.

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Aim: The study aims to develop and evaluate floating tablet formulations of ranitidine to overcome its short half-life (1.2–1.9 hours) and maintain stable plasma drug levels. This approach seeks to enhance drug bioavailability through gastroretentive systems using rate-modifying polymers. Methodology: Nine ranitidine floating tablet formulations (F1-F9) were prepared using a multiple punch tablet compression machine with 9 mm round flat-faced punches, each containing 80 mg of ranitidine. Hydroxypropyl methylcellulose (HPMC K15M, HPMC K100M) and xanthan gum were used as rate-modifying polymers.

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Sahu, Rimjhim, Deepika Jain, Rekha Mehani, Hemani ., Lal Hingorani, and Vijay Thawani. "Novel poly herbal muco-adhesive formulation for treatment of oral aphthous ulcer." International Journal of Basic & Clinical Pharmacology 10, no. 8 (2021): 906. http://dx.doi.org/10.18203/2319-2003.ijbcp20212811.

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Background: Oral ulcers are the most frequent lesions that cause discomfort for which the patients seek treatment for alleviating pain and facilitate early healing. Various treatment modalities from modern medicine and Ayurveda are used in the form of ointments and mouthwashes with varying efficacy. Anti-inflammatory medicines, enzymatic preparations, gamma globulins and immune suppressants have been used.Methods: Extracts of five chosen herbs, Glycyrrhiza glabra, Acacia catechu, Punica Granatum, Curcuma longa and Mentha piperita were used for preparing mucoadhesive gel for the treatment of or

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Agarwal, Mansi, Monika Sachdeva, and Pankaj Kumar Sharma. "Development and Characterization of novel bigel of loxoprofen for topical drug delivery." Journal of Drug Delivery and Therapeutics 12, no. 5 (2022): 46–54. http://dx.doi.org/10.22270/jddt.v12i5.5579.

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Bigels are unique two-phase systems that have recently been presented as a structured method for active ingredient application. The purposes of the current study were to develop and characterize bigel formulations containing loxoprofen. They have the benefits of both hydrogel and organo-gel. In order to enhance penetration, pluronic lecithin was added to form the organo-gel, and HPMC was added to form the hydrogel, which properly hydrates the stratum corneum. Bigels were produced by mixing hydrogel with organo-gel in the appropriate ratio. pH, viscosity, extrudability, spreadability, and Gel-s

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da Cruz, Luiza Pereira Dias, Robert G. Hill, Xiaojing Chen, and David G. Gillam. "Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes." International Journal of Dentistry 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/5701638.

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There are numerous over-the-counter (OTC) and professionally applied (in-office) products and techniques currently available for the treatment of dentine hypersensitivity (DH), but more recently, the use of bioactive glasses in toothpaste formulations have been advocated as a possible solution to managing DH. Aim. The aim of the present study, therefore, was to compare several bioactive glass formulations to investigate their effectiveness in an established in vitro model. Materials and Methods. A 45S5 glass was synthesized in the laboratory together with several other glass formulations: (1)

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Polovic, Natalija, and Tanja Velickovic. "Novel Formulations for Oral Allergen Vaccination." Recent Patents on Inflammation & Allergy Drug Discovery 2, no. 3 (2008): 215–21. http://dx.doi.org/10.2174/187221308786241956.

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Saraf, S., and CD Kaur. "Phytoconstituents as photoprotective novel cosmetic formulations." Pharmacognosy Reviews 4, no. 7 (2010): 1. http://dx.doi.org/10.4103/0973-7847.65319.

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Zughaier, Susu M. "Analysis of novel meningococcal vaccine formulations." Human Vaccines & Immunotherapeutics 13, no. 7 (2017): 1728–32. http://dx.doi.org/10.1080/21645515.2017.1305528.

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Marotti de Sciarra, Francesco. "Novel variational formulations for nonlocal plasticity." International Journal of Plasticity 25, no. 2 (2009): 302–31. http://dx.doi.org/10.1016/j.ijplas.2008.02.002.

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Bach, Horacio, and David L. Gutnick. "Novel polysaccharide–protein-based amphipathic formulations." Applied Microbiology and Biotechnology 71, no. 1 (2006): 34–38. http://dx.doi.org/10.1007/s00253-005-0149-9.

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Trovato, Maria. "Delivery strategies for novel vaccine formulations." World Journal of Virology 1, no. 1 (2012): 4. http://dx.doi.org/10.5501/wjv.v1.i1.4.

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Freitas, Maria Eliza, Marta Ruiz-Lopez, and Susan H. Fox. "Novel Levodopa Formulations for Parkinson’s Disease." CNS Drugs 30, no. 11 (2016): 1079–95. http://dx.doi.org/10.1007/s40263-016-0386-8.

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Sagar, A. Sarode* Abhishekh U. Thakare Tejas V. Somawanshi Mayuri A. Sarode Rohini K. Suralkar Yogesh N. Sonawane Parag R. Patil. "Microencapsulation Technology for Novel Pharmaceutical Formulations." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 77–97. https://doi.org/10.5281/zenodo.10616854.

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<strong> </strong> Microencapsulation is essentially a method or process that forms microcapsules by applying thin coatings to dispersions, small solid particles, or liquid droplets in a repeatable manner. Its particle size ranges from several tenths of a micron to 5000μ, which makes it easily distinguishable from other coating techniques. The microencapsulation process offers solutions for a number of issues, including how to make prolonged-action dosage forms, mask the taste of bitter medications, separate incompatible materials, shield chemicals from oxidation or moisture, and chang

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