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Relevant bibliographies by topics / Novel gene functions

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Academic literature on the topic 'Novel gene functions'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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Journal articles on the topic "Novel gene functions"

1

Ghanta, Krishna Sumanth, Da-Qiang Li, Jeyanthy Eswaran, and Rakesh Kumar. "Gene Profiling of Mta1 Identifies Novel Gene Targets and Functions." PLoS ONE 6, no. 2 (2011): e17135. http://dx.doi.org/10.1371/journal.pone.0017135.

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Aoki, Hitomi. "Novel Rest functions revealed by conditional gene ablation." Medical Molecular Morphology 51, no. 3 (2018): 129–38. http://dx.doi.org/10.1007/s00795-018-0187-x.

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Araújo, Ana Rita, Micael Reis, Helder Rocha, et al. "The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions." PLoS ONE 8, no. 5 (2013): e63747. http://dx.doi.org/10.1371/journal.pone.0063747.

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Wright, Ernest M., Chiara Ghezzi, and Donald D. F. Loo. "Novel and Unexpected Functions of SGLTs." Physiology 32, no. 6 (2017): 435–43. http://dx.doi.org/10.1152/physiol.00021.2017.

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It has been 30 years since the intestinal sodium glucose cotransporter SGLT1 was cloned, and, in the intervening years, there have been many advances that have influenced physiology and medicine. Among the first was that SGLT1 is the founding member of the human gene family SLC5, containing 11 diverse transporters and a glucose sensor. Equally surprising was that SGLTs are members of a structural family of cotransporters and exchangers in different gene families. This led to the conclusion that these proteins operate by a mechanism where transport involves the opening and closing of external a

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Rho, Mina, and Woon Ju Song. "Discovery of Novel Gene Functions by Chemistry-Guided Targeted Sequence Analysis." Biochemistry 59, no. 1 (2019): 10–11. http://dx.doi.org/10.1021/acs.biochem.9b00790.

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Reddy, Chandan K., and Mohammad S. Aziz. "Predicting gene functions from multiple biological sources using novel ensemble methods." International Journal of Data Mining and Bioinformatics 12, no. 2 (2015): 184. http://dx.doi.org/10.1504/ijdmb.2015.069418.

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Musso, G., M. Tasan, C. Mosimann, et al. "Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish." Development 141, no. 1 (2013): 224–35. http://dx.doi.org/10.1242/dev.099796.

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Walton, Felicia J., Alexander Idnurm, and Joseph Heitman. "Novel gene functions required for melanization of the human pathogenCryptococcus neoformans." Molecular Microbiology 57, no. 5 (2005): 1381–96. http://dx.doi.org/10.1111/j.1365-2958.2005.04779.x.

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Okabe, Shinichiro, Tetsuya Fukuda, Kazuki Ishibashi, et al. "BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor." Molecular and Cellular Biology 18, no. 7 (1998): 4235–44. http://dx.doi.org/10.1128/mcb.18.7.4235.

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ABSTRACT The BCL6 gene, which has been identified from the chromosomal translocation breakpoint in B-cell lymphomas, functions as a sequence-specific transcriptional repressor. We cloned a novelBcl6-homologous gene, BAZF (encoding Bcl6-associated zinc finger protein). The predicted amino acid sequence of BAZF indicated that the BTB/POZ domain and the five repeats of the Krüppel-like zinc finger motif are located in the NH2-terminal region and the COOH-terminal region, respectively. BAZF associated with Bcl6 at the BTB/POZ domain and localized in the nucleus. Since zinc finger motifs of BAZF w

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Stork, Oliver, Alexander Zhdanov, Alexei Kudersky, Takeo Yoshikawa, Kunihiko Obata, and Hans-Christian Pape. "Neuronal Functions of the Novel Serine/Threonine Kinase Ndr2." Journal of Biological Chemistry 279, no. 44 (2004): 45773–81. http://dx.doi.org/10.1074/jbc.m403552200.

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We have identified a novel member of the Ndr subfamily of serine/threonine protein kinases, Ndr2, as a gene product that is induced in the mouse amygdala during fear memory consolidation and examined a possible function of this kinase in neural differentiation. Expression ofNdr2mRNA was detected in various cortical and subcortical brain regions, as well as non-neuronal tissues. Its expression in the amygdala was increased 6 h after Pavlovian fear conditioning training and returned to control levels within 24 h. To study intracellular localization and functions of Ndr2, EGFP::Ndr2 fusion protei

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Dissertations / Theses on the topic "Novel gene functions"

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Steinke, Dirk. "Gene and genome duplication and the evolution of novel gene functions." [S.l. : s.n.], 2006.

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Mylne, Joshua Scott. "Finding functions for novel and orphan arabidopsis genes : the EST advantage /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16435.pdf.

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Hammargren, Jenni. "Novel functions of the mitochondrial nucleoside diphosphate kinase in plants /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200787.pdf.

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Fisk, Dianna G. "CRP1 : founding member of a novel protein family that functions in organellar gene expression /." view abstract of download file of text, 2000. http://wwwlib.umi.com/cr/uoregon/fullcit?p9987422.

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Prescott, Jack. "Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277025.

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The NF-kB signalling pathway is a critical mediator of the cellular responses to inflammatory cytokines. The IκB kinase (IKK) complex, which is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. Seminal genetic studies in knockout (KO) mouse embryonic fibroblasts (MEFs) have defined two pathways of NF-κB activation; a canonical pathway, activated in response to cytokines such as TNFα/IL-1β, that requires NEMO and predominantly IKKβ catalytic activity; and a non-canonical pathway, activat

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Nishida, Michio. "Novel humanized anti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions." Kyoto University, 2008. http://hdl.handle.net/2433/124332.

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Singh, Sandeep. "Novel mechanism in astrocyte gene regulation and function." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/112.

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This dissertation sheds light on several novel mechanistic findings in astrocyte specific gene regulation and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional activation (TA) domain completely conserved in primates. In contrast to previously cloned NFI-X1, overexpression of NFI-X3 potently activates NFI reporters, including GFAP reporter, in astrocytes and glioma cells. The expression of N

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Thorpe, Karen Louise. "Gene structure, phylogeny and mutation analysis of RING3 : a novel MHC-encoded gene." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325009.

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Guterstam, Peter. "Cell-penetrating peptides, novel synthetic nucleic acids, and regulation of gene function : Reconnaissance for designing functional conjugates." Licentiate thesis, Stockholm : Department of Neurochemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7491.

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Tan, Keith Sze Cyeak. "Functional characterisation of the novel gene product PLU-1." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415469.

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Books on the topic "Novel gene functions"

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Axel, Meyer, and Peer Yves van de, eds. Genome evolution: Gene and genome duplications and the origin of novel gene functions. Kluwer Academic Pub., 2003.

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(Editor), A. Meyer, and Y. van de Peer (Editor), eds. Genome Evolution: Gene and Genome Duplications and the Origin of Novel Gene Functions. Springer, 2003.

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Capone, George T. Down Syndrome. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0056.

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People with Down syndrome (trisomy 21) are distinguished by having an extra copy of chromosome 21. Chromosome 21 contains an estimated 562 genes, including 161 known to code for functional proteins, and at least 396 considered novel. Gene dosage imbalance is the primary mechanism, which results in the molecular, cellular, histological, and anatomical features characteristic of the condition. Throughout brain development, major neurobiological events go awry, resulting in a differently organized brain and characteristic developmental delays noted during infancy and the preschool years. The cons

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Chang, Michael. Identification of novel DNA damage response genes using functional genomics. 2005.

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Powell, Craig M. SHANK Gene Family and Autism. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0011.

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SHANK3 deletion/mutation is an independently replicated, genetic cause of autism (Durand et al., 2007; Gauthier et al., 2009; Moessner et al., 2007) and is the major causative gene in the 22q13 deletion syndrome known as Phelan-McDermid syndrome (Bonaglia et al., 2011; Bonaglia et al., 2001; Bonaglia et al., 2006; Chen et al., 2011; Delahaye et al., 2009; Dhar et al., 2010; Jeffries et al., 2005; Misceo et al., 2011; Sarasua et al., 2011; Wilson et al., 2003). Patients with Phelan-McDermid syndrome uniformly have delayed or absent speech and many carry the diagnosis of autism spectrum disorder

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Buxbaum, Joseph D. An Overview of the Genetics of Autism Spectrum Disorders. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0004.

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There is very good evidence for a strong genetic component to the autism spectrum disorders (ASDs), which include autistic disorder, Asperger syndrome, pervasive developmental disorder not otherwise specified, and Rett syndrome. At the same time, identifying the loci contributing to ASD risk has proven difficult because of extreme heterogeneity. However, in spite of these difficulties, many ASD loci have been identified and, even using current clinical measures, an etiological diagnosis can be given in upward of 20% of cases. With the introduction of “second-generation” sequencing, gene discov

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Anderson, Greg. Living as One Liked. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190886646.003.0014.

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As Michel Foucault and his followers have amply demonstrated, modern liberal “government” in the broadest sense has ultimately been about producing a historically novel kind of subject, one who is equipped in body and mind to flourish as an individual in a modern capitalist environment and thereby contribute to the net well-being of all. In Athens, by contrast, it was taken for granted that subjects were already fully equipped to govern themselves. Thus, it was simply assumed that members of different households would not only secure their own domestic well-being but also collaborate with othe

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Keymer, Thomas. Fictions of the Union. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199574803.003.0023.

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This chapter looks at the fictions of the Union. At the culmination of her influential essay ‘On the Origin and Progress of Novel-Writing’, originally prefixed to her multi-volume anthology The British Novelists (1810), Anna Laetitia Barbauld makes an arresting claim for the nation-building potential of the novel genre. Where Jane Austen focuses on generalities and universals, Barbauld emphasizes instead the public function of novels, and of the canon enshrined in her anthology. She does so a century after the British nation had been formally inaugurated by the 1707 Act of Union between Englan

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Davidson, Jenny. Restoration Theatre and the Novel. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199580033.003.0026.

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This chapter explores the broad cultural transition from drama to novel during the Restoration period, which triggered one of the most productive periods in the history of the London stage. However, when it comes to the eighteenth century proper, the novel is more likely to be identified as the century's most significant and appealing popular genre. The chapter considers why the novel has largely superseded drama as the literary form to which ambitious and imaginative literary types without a strong affinity for verse writing would by default have turned their attention and energies by the mid

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Ponomarev, Igor. Alcohol Use Disorder. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676001.003.0005.

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Alcohol use disorder (AUD) is characterized by clinically significant impairments in health and social function. Epigenetic mechanisms of gene regulation may provide an attractive explanation for how early life exposures to alcohol contribute to the development of AUD and exert lifelong effects on the brain. This chapter provides a critical discussion of the role of epigenetic mechanisms in AUD etiology and the potential of epigenetic research to improve diagnosis, evaluate risks for alcohol-induced pathologies, and promote development of novel therapies for the prevention and treatment of AUD

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Book chapters on the topic "Novel gene functions"

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Bosch, L., B. Kraal, J. M. Van Noort, E. Vijgenboom, J. H. M. van Delft, and A. Talens. "Novel Functions of EF-Tu during Polypeptide Synthesis and tuf Gene Expression." In Springer Series in Molecular Biology. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4884-2_38.

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Colten, H. R. "Tissue Specific Complement Gene Expression: Evidence for Novel Functions of the Complement Proteins." In Progress in Immunology Vol. VIII. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-51479-1_63.

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Turpin, Baptiste, Eline Y. Bijman, Hans-Michael Kaltenbach, and Jörg Stelling. "Population Design for Synthetic Gene Circuits." In Computational Methods in Systems Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85633-5_11.

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AbstractSynthetic biologists use and combine diverse biological parts to build systems such as genetic circuits that perform desirable functions in, for example, biomedical or industrial applications. Computer-aided design methods have been developed to help choose appropriate network structures and biological parts for a given design objective. However, they almost always model the behavior of the network in an average cell, despite pervasive cell-to-cell variability. Here, we present a computational framework to guide the design of synthetic biological circuits while accounting for cell-to-cell variability explicitly. Our design method integrates a NonLinear Mixed-Effect (NLME) framework into an existing algorithm for design based on ordinary differential equation (ODE) models. The analysis of a recently developed transcriptional controller demonstrates first insights into design guidelines when trying to achieve reliable performance under cell-to-cell variability. We anticipate that our method not only facilitates the rational design of synthetic networks under cell-to-cell variability, but also enables novel applications by supporting design objectives that specify the desired behavior of cell populations.

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Maskos, Uwe, Sylvie Granon, Philippe Faure, and Jean-Pierre Changeux. "Nicotinic Acetylcholine Receptor Functions in the CNS Investigated with a Novel Method of Stereotaxic Gene Re-expression in Knockout Mice." In Novartis Foundation Symposia. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470029237.ch6.

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Toyo-oka, Teruhiko, Toshihiro Tanaka, Licht Toyo-oka, and Katsushi Tokunaga. "A Novel Algorithm from Personal Genome to the Pathogenic Mutant Causing Mitochondrial Cardiomyopathy." In Genes and Cardiovascular Function. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-7207-1_9.

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Talukdar, D. "2. Mutagenesis as functional biology tool in the improvement of legumes." In Mutagenesis: exploring novel genes and pathways. Wageningen Academic Publishers, 2014. http://dx.doi.org/10.3920/978-90-8686-787-5_2.

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Degaki, Theri Leica, Marcos Angelo Almeida Demasi, and Mari Cleide Sogayar. "Functional Role of the Novel NRP/B Tumor Suppressor Gene." In Tumors of the Central Nervous system, Volume 3. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1399-4_11.

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Carty, Michael, Sinéad Keating, and Andrew Bowie. "Uncovering Novel Gene Function in Toll-Like Receptor Signalling Using siRNA." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-541-1_17.

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González-Pastor, José E., and Salvador Mirete. "Novel Metal Resistance Genes from Microorganisms: A Functional Metagenomic Approach." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-823-2_19.

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Kurada, Ramachandra Rao, K. Karteeka Pavan, and Allam Appa Rao. "Automatic Teaching–Learning-Based Optimization: A Novel Clustering Method for Gene Functional Enrichments." In SpringerBriefs in Applied Sciences and Technology. Springer Singapore, 2014. http://dx.doi.org/10.1007/978-981-287-338-5_2.

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Conference papers on the topic "Novel gene functions"

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Xiao, Mi, Liang Gao, Xinyu Shao, Haobo Qiu, and Li Nie. "Comparison of Gene Expression Programming and Common Metamodeling Techniques in Engineering Design." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47130.

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To reduce the tremendous computational expense of implementing complex simulation and analysis in engineering design, more and more researchers pay attention to the construction of approximation models. The approximation models, also called surrogate models and metamodels, can be utilized to replace simulation and analysis codes for design and optimization. Commonly used metamodeling techniques include response surface methodology (RSM), kriging and radial basis functions (RBF). In this paper, gene expression programming (GEP) algorithm in evolutionary computing is investigated as an alternati

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Sudhakar Patil, Sahil, Darshit Shetty, and Vaibhav S. Pawar. "Novel Machine Learning Algorithm for Prevalent Gene Biomarkers for Effective Cancer Treatment by Detecting its PH." In 11th International Conference on Computer Science and Information Technology (CCSIT 2021). AIRCC Publishing Corporation, 2021. http://dx.doi.org/10.5121/csit.2021.110713.

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Patterns discovered from based on collected molecular profiles of patient tumour samples, and also clinical metadata, could be used to provide personalized cancer treatment to patients with similar molecular subtypes. Computational algorithms for cancer diagnosis, prognosis, and therapeutics that can recognize specific functions and aid in classifiers based on a plethora of publicly accessible cancer research outcomes are needed. Machine learning, a branch of artificial intelligence, has a great deal of potential for problem solving in cryptic cancer datasets, as per a literature study. We foc

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Srivastava, Jyoti, Ayesha Siddiq, Luni Emdad, et al. "Abstract 1324: Unraveling novel functions of the oncogene Astrocyte elevated gene-1 (AEG-1) contributing to hepatocarcinogenesis employing a transgenic mouse model." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1324.

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Dhar, Sanjit K., Edward Kasarskis, Haining Zhu, Bert C. Lynn, and Daret K. St Clair. "Abstract 2964: Transcriptional regulation of manganese superoxide dismutase gene reveals a novel mechanism by which FUS/TLS functions as a tumor suppressor." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2964.

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Ong, Bruce A., Julian L. Allen, Jason Caboot, Oscar H. Mayer, Patrick Sleiman, and Hakon Hakonarson. "Gene Network Analysis Identifies Novel Lung Function Genes." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6024.

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Ong, Bruce A., Jason Caboot, Julian Allen, et al. "Gene Network Analysis In A Pediatric Cohort Identifies Novel Lung Function Genes." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3488.

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Renner, A., and A. Aszódi. "HIGH-THROUGHPUT FUNCTIONAL ANNOTATION OF NOVEL GENE PRODUCTS USING DOCUMENT CLUSTERING." In Proceedings of the Pacific Symposium. WORLD SCIENTIFIC, 1999. http://dx.doi.org/10.1142/9789814447331_0006.

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Pejaver, Vikas Rao, and Sun Kim. "Gene cluster profile vectors: A novel method to infer functional coupling using both gene proximity and co-occurrence profiles." In 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2010. http://dx.doi.org/10.1109/bibm.2010.5706530.

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Tian, Zhen, Haichuan Fang, Yangdong Ye, and Zhenfeng Zhu. "SWE: a novel method with semantic-weighted edge for measuring gene functional similarity." In 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2020. http://dx.doi.org/10.1109/bibm49941.2020.9313495.

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Gara, Sudheer Kumar, Yi Liu-Chittenden, Shweta Kotian, Dhaval Patel, and Electron Kebebew. "Abstract 3578: Novel insights into the cellular function and gene regulation of a master mutator, APOBEC3B." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3578.

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Reports on the topic "Novel gene functions"

1

Li, Weiquan. FoxP3 Functions as a Novel Breast Cancer Suppressor Gene Through Cooperation with NFAT. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada524945.

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Conklin, Douglas S. Functional Geno,ic Analysis of Breast Cancer Cell Tumorigenicity Using a Noval Gene Silencing Resource. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada467802.

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King, Mary-Claire, and Piri L. Welcsh. Novel Functional Screen for New Breast Cancer Genes. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada433029.

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Wang, Ruoxiang. Functional Characterization of a Novel Prostate-Specific Gene PrLZ in Prostate Cancer. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada609546.

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Bennett, Craig B. A Functional Genomics Approach to Identify Novel Breast Cancer Gene Targets in Yeast. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada437737.

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Bennett, Craig B. A Functional Genomics Approach to Idenitfy Novel Breast Cancer Gene Targets in Yeast. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada459201.

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Conklin, Douglas S. Functional Genomic Analysis of Breast Cancer Cell Tumorigenicity Using a Novel Gene Silencing Resource. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443048.

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Abdel-Mageed, Asim B., Krishna C. Agrawal, Jr Crawford, and Byron. Functional Characterization of Two Novel Human Prostate Cancer Metastasis Related Genes. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada493881.

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Abdel-Mageed, Asim B. Functional Characterization of Two Novel Human Prostate Cancer Metastasis Related Genes. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada460439.

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Conklin, Douglas S. Functional Geonic Analysis of Breast Cancer Cell Tumorigenicity Using a Noval Gene Silencing Resource. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada477002.

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