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Books on the topic 'Novel gene functions'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Axel, Meyer, and Peer Yves van de, eds. Genome evolution: Gene and genome duplications and the origin of novel gene functions. Kluwer Academic Pub., 2003.

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2

(Editor), A. Meyer, and Y. van de Peer (Editor), eds. Genome Evolution: Gene and Genome Duplications and the Origin of Novel Gene Functions. Springer, 2003.

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3

Capone, George T. Down Syndrome. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0056.

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People with Down syndrome (trisomy 21) are distinguished by having an extra copy of chromosome 21. Chromosome 21 contains an estimated 562 genes, including 161 known to code for functional proteins, and at least 396 considered novel. Gene dosage imbalance is the primary mechanism, which results in the molecular, cellular, histological, and anatomical features characteristic of the condition. Throughout brain development, major neurobiological events go awry, resulting in a differently organized brain and characteristic developmental delays noted during infancy and the preschool years. The cons

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4

Chang, Michael. Identification of novel DNA damage response genes using functional genomics. 2005.

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5

Powell, Craig M. SHANK Gene Family and Autism. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0011.

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SHANK3 deletion/mutation is an independently replicated, genetic cause of autism (Durand et al., 2007; Gauthier et al., 2009; Moessner et al., 2007) and is the major causative gene in the 22q13 deletion syndrome known as Phelan-McDermid syndrome (Bonaglia et al., 2011; Bonaglia et al., 2001; Bonaglia et al., 2006; Chen et al., 2011; Delahaye et al., 2009; Dhar et al., 2010; Jeffries et al., 2005; Misceo et al., 2011; Sarasua et al., 2011; Wilson et al., 2003). Patients with Phelan-McDermid syndrome uniformly have delayed or absent speech and many carry the diagnosis of autism spectrum disorder

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6

Buxbaum, Joseph D. An Overview of the Genetics of Autism Spectrum Disorders. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199744312.003.0004.

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There is very good evidence for a strong genetic component to the autism spectrum disorders (ASDs), which include autistic disorder, Asperger syndrome, pervasive developmental disorder not otherwise specified, and Rett syndrome. At the same time, identifying the loci contributing to ASD risk has proven difficult because of extreme heterogeneity. However, in spite of these difficulties, many ASD loci have been identified and, even using current clinical measures, an etiological diagnosis can be given in upward of 20% of cases. With the introduction of “second-generation” sequencing, gene discov

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7

Anderson, Greg. Living as One Liked. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190886646.003.0014.

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As Michel Foucault and his followers have amply demonstrated, modern liberal “government” in the broadest sense has ultimately been about producing a historically novel kind of subject, one who is equipped in body and mind to flourish as an individual in a modern capitalist environment and thereby contribute to the net well-being of all. In Athens, by contrast, it was taken for granted that subjects were already fully equipped to govern themselves. Thus, it was simply assumed that members of different households would not only secure their own domestic well-being but also collaborate with othe

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8

Keymer, Thomas. Fictions of the Union. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199574803.003.0023.

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This chapter looks at the fictions of the Union. At the culmination of her influential essay ‘On the Origin and Progress of Novel-Writing’, originally prefixed to her multi-volume anthology The British Novelists (1810), Anna Laetitia Barbauld makes an arresting claim for the nation-building potential of the novel genre. Where Jane Austen focuses on generalities and universals, Barbauld emphasizes instead the public function of novels, and of the canon enshrined in her anthology. She does so a century after the British nation had been formally inaugurated by the 1707 Act of Union between Englan

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9

Davidson, Jenny. Restoration Theatre and the Novel. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199580033.003.0026.

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This chapter explores the broad cultural transition from drama to novel during the Restoration period, which triggered one of the most productive periods in the history of the London stage. However, when it comes to the eighteenth century proper, the novel is more likely to be identified as the century's most significant and appealing popular genre. The chapter considers why the novel has largely superseded drama as the literary form to which ambitious and imaginative literary types without a strong affinity for verse writing would by default have turned their attention and energies by the mid

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10

Ponomarev, Igor. Alcohol Use Disorder. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676001.003.0005.

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Alcohol use disorder (AUD) is characterized by clinically significant impairments in health and social function. Epigenetic mechanisms of gene regulation may provide an attractive explanation for how early life exposures to alcohol contribute to the development of AUD and exert lifelong effects on the brain. This chapter provides a critical discussion of the role of epigenetic mechanisms in AUD etiology and the potential of epigenetic research to improve diagnosis, evaluate risks for alcohol-induced pathologies, and promote development of novel therapies for the prevention and treatment of AUD

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11

Dworkin, Ian, Daniel A. Fung, and Timothy T. Davis. Biologic and Regenerative Therapies. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0027.

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Low back pain is one of the most debilitating conditions worldwide, and a major cause is degenerative disc disease. Current therapies range from conservative treatments, such as medications, physical therapy, and other modalities, to more invasive treatments such as injections and surgery; however, these therapies neither stop the progression of degeneration nor restore function to the degenerating disc; they focus on symptom management, not on etiology. A novel approach to treating degenerative disc disease involves using regenerative therapies such as stem cells, growth factors, and gene the

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12

Lewis, Myles, and Tim Vyse. Genetics of connective tissue diseases. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0042.

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The advent of genome-wide association studies (GWAS) has been an exciting breakthrough in our understanding of the genetic aetiology of autoimmune diseases. Substantial overlap has been found in susceptibility genes across multiple diseases, from connective tissue diseases and rheumatoid arthritis (RA) to inflammatory bowel disease, coeliac disease, and psoriasis. Major technological advances now permit genotyping of millions of single nucleotide polymorphisms (SNPs). Group analysis of SNPs by haplotypes, aided by completion of the Hapmap project, has improved our ability to pinpoint causal ge

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13

Rosen, Jeremy. Minor Characters Have Their Day. Columbia University Press, 2017. http://dx.doi.org/10.7312/columbia/9780231177443.001.0001.

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How do genres develop? In what ways do they reflect changing political and cultural trends? What do they tell us about the motivations of publishers and readers? Combining close readings and formal analysis with a sociology of literary institutions and markets, Minor Characters Have Their Day offers a compelling new approach to genre study and contemporary fiction. Focusing on the booming genre of books that transform minor characters from canonical literary texts into the protagonists of new works, Jeremy Rosen makes broader claims about the state of contemporary fiction, the strategies of th

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14

Platte, Nathan. From the Ranch to the Drawing Room. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199371112.003.0012.

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In story and production, Duel in the Sun and The Paradine Case have little in common, but it is precisely their contrasts that show how music served both a more elaborate and experimental function in Selznick’s postwar films. For Duel, Selznick construed a genre-bending western of operatic proportions, striving for “an equivalent of [Wagner’s] Tristan.” Inspired and intimidated by the comparison, composer Dimitri Tiomkin churned out music, much of it rejected. From film to soundtrack album, Tiomkin relied upon choral director Jester Hairston and editor Audray Granville to realize the film’s mu

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15

Moore, Helen. Amadis in English. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198832423.001.0001.

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This is a book about readers: readers reading, and readers writing. They are readers of all ages and from all ages: young and old, male and female, from Europe and the Americas. The book they are reading is the Spanish chivalric romance known in English as Amadis de Gaule. Famous throughout the sixteenth century as the pinnacle of its fictional genre, the cultural functions of Amadis were further elaborated by the publication of Cervantes’s Don Quixote in 1605, in which Amadis features as Quixote’s favourite book. Amadis thereby becomes, as the philosopher Ortega y Gasset terms it, ‘enclosed’

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