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Dissertations / Theses on the topic 'Novel gene functions'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Steinke, Dirk. "Gene and genome duplication and the evolution of novel gene functions." [S.l. : s.n.], 2006.

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2

Mylne, Joshua Scott. "Finding functions for novel and orphan arabidopsis genes : the EST advantage /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16435.pdf.

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3

Hammargren, Jenni. "Novel functions of the mitochondrial nucleoside diphosphate kinase in plants /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200787.pdf.

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4

Fisk, Dianna G. "CRP1 : founding member of a novel protein family that functions in organellar gene expression /." view abstract of download file of text, 2000. http://wwwlib.umi.com/cr/uoregon/fullcit?p9987422.

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5

Prescott, Jack. "Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277025.

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The NF-kB signalling pathway is a critical mediator of the cellular responses to inflammatory cytokines. The IκB kinase (IKK) complex, which is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. Seminal genetic studies in knockout (KO) mouse embryonic fibroblasts (MEFs) have defined two pathways of NF-κB activation; a canonical pathway, activated in response to cytokines such as TNFα/IL-1β, that requires NEMO and predominantly IKKβ catalytic activity; and a non-canonical pathway, activat

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6

Nishida, Michio. "Novel humanized anti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions." Kyoto University, 2008. http://hdl.handle.net/2433/124332.

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7

Singh, Sandeep. "Novel mechanism in astrocyte gene regulation and function." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/112.

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This dissertation sheds light on several novel mechanistic findings in astrocyte specific gene regulation and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional activation (TA) domain completely conserved in primates. In contrast to previously cloned NFI-X1, overexpression of NFI-X3 potently activates NFI reporters, including GFAP reporter, in astrocytes and glioma cells. The expression of N

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8

Thorpe, Karen Louise. "Gene structure, phylogeny and mutation analysis of RING3 : a novel MHC-encoded gene." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325009.

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9

Guterstam, Peter. "Cell-penetrating peptides, novel synthetic nucleic acids, and regulation of gene function : Reconnaissance for designing functional conjugates." Licentiate thesis, Stockholm : Department of Neurochemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7491.

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10

Tan, Keith Sze Cyeak. "Functional characterisation of the novel gene product PLU-1." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415469.

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11

Young, Sheila. "Molecular and functional characterisation of a novel gene, DIR1." Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428616.

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12

Lares, Monica Rae Jung. "Insights into the function of a novel RNA gene : HAR1 /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2009. http://uclibs.org/PID/11984.

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13

Chau, You-Ying. "Characterisation of the function(s) of a novel gene, CLWD." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29060.

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The aim of my PhD is to investigate the function(s) of <i>CLWD</i> by characterising its location in cells and in tissues, as well as the phenotype of cells where <i>CLWD </i>is knocked down using siRNA. Results from indirect immunofluoresence suggest that CLWD may be a new component in the mitotic spindle. CLWD localises to centrosomes in prometaphase and moves to mitotic spindles in metaphase. Results from immunohistochemistry show that <i>CLWD </i>is expressed in a wide range of tissues with strong expression in the epithelial areas of tissues. In addition, <i>CLWD </i>is located on human c

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14

Jadhav, Trishul. "Knowledge Based Gene Set analysis (KB-GSA) : A novel method for gene expression analysis." Thesis, University of Skövde, School of Life Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-4352.

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<p>Microarray technology allows measurement of the expression levels of thousand of genes simultaneously. Several gene set analysis (GSA) methods are widely used for extracting useful information from microarrays, for example identifying differentially expressed pathways associated with a particular biological process or disease phenotype. Though GSA methods like Gene Set Enrichment Analysis (GSEA) are widely used for pathway analysis, these methods are solely based on statistics. Such methods can be awkward to use if knowledge of specific pathways involved in particular biological processes a

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15

Prochnow, Blair Raymond. "Analyzing gene function in the mouse gene trap mutations in Arp3, Lsm16, and a novel KRAB-ZF gene /." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983475202.

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16

Hares, John Michael. "Unravelling the function of the novel gene, day, in Drosophila melanogaster." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/27947.

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Circadian rhythms in biological outputs are seen in numerous phyla that live in cyclical environments. Regulation of these behaviours has been examined in the fruit fly Drosophila melanogaster, with many of its genes sharing mammalian homologs. One component of the molecular clockwork of particular interest is the light activated cryptochrome (cry) gene; cry has been shown to be important for a number of light driven behavioural outputs, including but not limited to: entrainment, response to brief light pulses, sensitivity to magnetic stimulus and negative geotaxis. A yeast two hybrid screen (

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17

White, Michael Alexander. "Regulation and function of a novel gene cluster in Campylobacter jejuni." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16261/.

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18

Wherley, Tanner. "Determining the Function and Effects of a Novel FOXO1 Fusion Gene." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268766164561.

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19

Wang, Shu-Ching Mary. "Functional role and transcriptional regulation of the novel SOX18 gene /." St. Lucia, Qld, 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18003.pdf.

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20

Sobieszczuk, Dorota Felicja. "Identification and functional analysis of a novel BTB-domain gene family." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430554.

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21

Fairclough, Victoria Ruth. "Functional Analysis of Novel Essential Genes of Staphylococcus aureus." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522041.

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22

AbuAli, Ghada. "ORCTL3 : insights into the function and the structure of a novel anticancer gene." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14660.

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ORCTL3 was recently isolated as a gene with a tumour-speci c apoptosis activity. Its transfection into transformed cells elicits an apoptosis response, while normal cells remain unaffected. In this study I show that ORCTL3 is activated for apoptosis induction by individual tumourigenic mutations in renal cells. Its activity is also shared by other so-called anticancer genes such as Mda-7/IL-24, TRAIL, Apoptin, and Par-4. This effect is independent of the tumour cells' proliferation status and is mediated by an incomplete ER stress response, characterised by ATF4, but not BiP accumulation. ATF4

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23

Roy, Poornima. "Regulation and function of MECOM (EVI1) novel target gene carbonic anhydrase III (caIII)." Thesis, Glasgow Caledonian University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.688279.

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24

Man, Kwun-nok Mimi. "Functional implications of cytoglobin, a novel protein, in liver fibrosis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38820730.

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25

Karlgren, Maria. "Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-139-5/.

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26

Wu, Yibo. "Genome Studies of Gene Expression and Alternative Splicing During iPSC Skeletal Muscle Induction and Differentiation." Digital WPI, 2019. https://digitalcommons.wpi.edu/etd-theses/1319.

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Facioscapulohumeral muscular dystrophy(FSHD) is a disorder characterized by muscle weakness and wasting (atrophy). This disease is typically inherited as autosomal dominant and has a complex genetic and epigenetic etiology. Our collaborator had differentiated healthy human pluripotent stem cells(iPSC) into skeletal muscles and exploited ISO-Seq to explore cell gene expression and transcript alternative splicing usage profile during 8 differentiation stages. Later, stage specific gene differential expression, transcript alternative splicing, gene ontology and novel gene/transcript were analysed

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27

Gibson, M. S. "A genetic and functional analysis of novel chicken interleukin-1 gene family members." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1338400/.

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The interleukin-1 gene family in humans comprises eleven members (IL-1F1-F11) that act as either functional agonists or antagonists of inflammation. Prior to this project, only two members of the IL-1 family had been identified and characterized in the chicken. The aim of this project was to identify, clone and characterise novel IL-1 family members in this species. EST sequences representing IL-1F5 (IL-36RN) and the secretory and intracellular structural variants of IL-1 receptor antagonist (IL-1RN) were identified by their similarity with chicken IL-1β. Chicken IL-1RN (chIL-1RN) cDNAs were i

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28

Yuan, Qingbo. "Identification and functional analysis of a novel flowering time gene Ef7 in rice." Kyoto University, 2009. http://hdl.handle.net/2433/123997.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第14685号<br>農博第1767号<br>新制||農||970(附属図書館)<br>学位論文||H21||N4458(農学部図書室)<br>UT51-2009-D397<br>京都大学大学院農学研究科農学専攻<br>(主査)教授谷坂隆俊, 教授遠藤隆, 教授稲村達也<br>学位規則第4条第1項該当

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29

Man, Kwun-nok Mimi, and 文冠諾. "Functional implications of cytoglobin, a novel protein, in liver fibrosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38820730.

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30

Graham, Stephanie M. "Using FlyAtlas to detect novel functions for well-known genes in Drosophila melanogaster." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3280/.

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Drosophila melanogaster has been an important model organism for over a century, cumulating in a vast array of mutant and transgenic stocks, the publication of the genome, its subsequent annotation and more recently the production of the online gene expression database, FlyAtlas. Much of what we know about developmental biology was pioneered in Drosophila and it is possibly the most well studied and understood model organism, in terms of development, genetics and physiology. The so-called ‘omics’ era of biology has resulted in a relatively data poor discipline quickly becoming a data rich one.

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31

Thomas, Anne L. "Structural and functional characteristics of novel mRNA isoforms of the death-promoting gene bax." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285747.

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32

Eve, A. M. J. "Identification and functional analyses of novel genes involved in haemovascular development." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1473223/.

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Characterising the transcriptome of the haemangioblast is of therapeutic interest. By profiling the precursor to both blood and endothelial cells, important candidate genes can be identified for further study, and contribute to our understanding of vascular development and disease. Using previously generated RNA-sequencing data, novel genes with roles in haemovascular development were functionally characterised. Previously, the Wnt signalling antagonist Tmem88a was shown to be necessary for primitive erythropoiesis. Using qPCR and in situ hybridisation the expression profile of tmem88a was cha

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33

Lornage, Xavière. "Identification and functional characterization of novel genes implicated in congenital myopathies." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ067.

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Les myopathies congénitales sont des maladies génétiques sévères caractérisées par une faiblesse musculaire très invalidante de début infantile. Afin d’identifier de nouvelles causes génétiques, nous avons séquencé les exomes de patients myopathes qui ne disposaient pas de diagnostic moléculaire et leur analyse a mis en évidence deux nouveaux gènes de myopathie. MYPN et ACTN2 codent pour deux protéines structurales du sarcomères appelées myopalladine et alphaactinine-2. Afin d’étudier l’impact des mutations sur la fonction de la protéine et sur la physiologie du muscle, des analyses moléculair

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34

Gonatopoulos-Pournatzis, Thomas. "Identification and functional characterisation of RAM, a novel and essential component of RNA guanine-7 methylation." Thesis, University of Dundee, 2012. https://discovery.dundee.ac.uk/en/studentTheses/a3138557-b75e-4534-a5db-47f09df416e5.

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Gene expression in eukaryotes is dependent on the N-7 methylguanosine cap, located at the 5’ end of RNA pol II transcripts, which marks pre-mRNA for processing, stabilisation and translation initiation. The enzymes that catalyse the formation of the N-7 methylguanosine cap are recruited to RNA pol II at the initial stages of transcription. The final step in this process, N-7 methylation of the guanosine cap, is catalysed by the RNA guanine-7 methyltransferase, RNMT. RNA guanine-7 methylation is an essential process for cell viability and its up-regulation has been associated with cell transfor

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35

Rubin, Carl-Johan. "Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8498.

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<p>Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements.</p><p>Animal models, mainly intercrosses between laboratory strains of mice, have been succesfully used to map genes affecting these traits, but may not mirror the multifactorial genetic etiology of highly complex traits such as osteoporosis.</p><p>Over the course of tens of thousand years humans have kept domestic anima

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36

Chittaranjan, Suganthi. "A functional genomics approach identifies novel genes involved in steroid-hormove induced programmed cell death in Drosophila." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2725.

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Programmed Cell death (PCD) is a highly conserved and genetically controlled event that plays important roles in animal development, homeostasis and disease. Our first objective was to discover and characterize new genes involved in PCD. Since many PCD genes are conserved in Drosophila, and steroid-induced PCD of larval salivary glands (SGs) is transcriptionally regulated with features of both apoptosis and autophagy, we used this exceptionally well-suited in vivo system and performed Serial Analysis of Gene Expression (SAGE) in three pre-death stages. SAGE identified 1244 expressed transcript

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37

Mulder, Michelle Anne. "The Mycobacterium tuberculosis KatG gene : identification of a novel function and analysis of the regulation of expression." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/25662.

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A clone containing the terminal third of the Mycobacterium tuberculosis katG gene was previously shown to confer resistance to ethyl methane sulfonate on DNA repair-deficient Escherichia coli cells. The first aim of this study, therefore, was to examine the role played by the M tuberculosis katG gene in DNA repair. The strategy used was overexpression of different regions of the gene in DNA repair-deficient mutants of E. coli, and examination of the sensitivities of the transformants to DNA damaging agents. Overexpression of the gene resulted in an increase in the survival of recA mutants expo

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38

He, Jin. "Lentiviral vectors mechanisms of transgene silencing and functional characterization of novel genes /." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006628.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.

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39

Khalil, Hilal Shahid. "Identification and characterization of novel autoregulatory mechanism controlling ataxia telangiectasia mutated gene expression, protein trafficking and function." Thesis, Abertay University, 2012. http://hdl.handle.net/10373/2179.

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Ataxia-telangiectasia mutated gene product (ATM) is a 350 kDa Serine/Threonine kinase belonging to the family of Phosphatidylinositol-3 kinase like kinases. ATM functions as a key element in DNA Damage Response (DDR), a mechanism that maintains genomic integrity within the cells. ATM is activated after double stranded DNA damage and initiates signalling cascades that determine the process of decision-making of cell fate and involves the participation of multiple proteins. This vital protein acts first by sensing double stranded DNA breaks and second by transducing the signal and activating oth

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40

Barrett, Angela Natalie. "Expression and function of a novel gene, PLU-1, with DNA / chromatin binding motifs in breast cancer." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409579.

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41

Balasubramaniyan, Rajarajeswari. "Gene expression data analysis using novel methods predicting time delayed correlations and evolutionarily conserved functional modules /." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0134/.

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42

Jurisic, Giorgia. "A systems genetics approach reveals novel modifier genes of lymphatic endothelium function in inflammation /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18541.

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43

Santarelli, Sara [Verfasser], and Mathias [Akademischer Betreuer] Schmidt. "The molecular and behavioral function of SLC6A15, a novel candidate gene for depression / Sara Santarelli ; Betreuer: Mathias Schmidt." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1117474313/34.

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44

Kim, Yun Cheol. "Novel strategies for studying gene and protein function random shRNA library synthesis and trasnposon directed base-exchange mutagenesis /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1693038461&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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45

Caronia, Giuliana. "A 147L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275109.

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46

Hallberg, Magnus. "Studies of Functional Interactions within Yeast Mediator and a Proposed Novel Mechanism for Regulation of Gene Expression." Doctoral thesis, Umeå : Uni, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-348.

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47

Serra, Tânia Sofia Lobato Paulo. "Regulation of the rice gene OsRMC under salt stress: identification and functional characterization of novel transcription factors." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/10532.

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Dissertation presented to obtain the Ph.D degree in Biology<br>Rice (Oryza sativa L.) is cultivated worldwide and is the staple food for more than one-half of the world population. Abiotic stress conditions, such as high salinity, drought and low temperature have a strong negative effect on rice production. High salinity severely affects rice growth and reduces grain yield, as it induces late flowering and lowers pollen viability. To cope with saline environments, plants rely on the perception and transduction of stress signals through specific response pathways, which activate several adaptat

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48

Burrows, Anna. "Genome-Wide Loss-of-Function Genetic Screens Identify Novel Senescence Genes and Putative Tumor Suppressors." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10191.

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During every cell cycle and upon exogenous stress, tumor suppression programs are engaged to ensure genomic stability. In response to replicative aging and oncogenic stimuli, the p53 and Rb pathways are activated to prevent the proliferation of damaged cells. Several lines of evidence suggest that escape from senescence is a crucial early step in oncogenic progression. A major challenge in the cancer field is to combine genomic information regarding cancer-associated genetic changes with high-throughput functional studies, in order to confirm genetic requirements and pinpoint biological roles

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49

Souopgui, Jacob. "Identification and functional characterization of novel genes involved in primary neurogenesis in Xenopus laevis." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96525710X.

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50

Almatrafi, Ahmed Mubrik. "Identification and functional characterisation of potential novel cancer-testis genes in human cancer cells." Thesis, Bangor University, 2014. https://research.bangor.ac.uk/portal/en/theses/identification-and-functional-characterisation-of-potential-novel-cancertestis-genes-in-human-cancer-cells(a368f7ee-0b71-47d3-979c-4233f0d256c8).html.

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