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Academic literature on the topic 'Novel on stage'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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Journal articles on the topic "Novel on stage"

1

Mugrib, Nuz Chairul, and Zulfah Zulfah. "Pilar’s Existence in Her Love Story Shown in Paulo Coelho’s By The River Piedra I Sat Down And Wept." NOBEL: Journal of Literature and Language Teaching 7, no. 2 (2016): 98–119. http://dx.doi.org/10.15642/nobel.2016.7.2.98-119.

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This research talks about existence found in ‘By the River Piedra I Sat Down and Wept’ novel by Paulo Coelho. This research focuses on Pilar as one of the main characters in the novel. The aim of this research is to describe Pilar’s characteristics and Pilar’s life to get her existence through her love story in the novel. It is a descriptive study. It is a library based study that collects data from the novel. The result of this research shows that Pilar as one of the main characters in the novel is a dynamic character. Pilar is initially described as lacking self-confidence and fearful woman and she finally becomes a self-confident and brave woman. Besides that, love story of Pilar’s life brings Pilar to some stages of existence that is aesthetic stage, ethic stage and religious stage as the peak of stage in life.

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Chen, Hua Wei, De Huai Jiang, and Ichiro Hagiwara. "Development of Novel XY Micropositioning Stage." Key Engineering Materials 407-408 (February 2009): 103–6. http://dx.doi.org/10.4028/www.scientific.net/kem.407-408.103.

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Along with the rapid development of semiconductor, photonics and ultra-precision engineering, ultra-precision positioning stages are becoming more necessary than ever. In this study, one novel XY micropositioning stage is proposed, in which bi-axis circular notch flexure and cantilever hinge mechanism are optimal designed as bearing to provide smooth and guided motion. The theoretical stiffness of stage is provided and verified by FEM analysis. Finally, the micro-positioning stage is built and its resolution is experimentally validated to be less than 4nm.

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Kis, B., A. Schrag, Y. Ben-Shlomo, et al. "Novel three-stage ascertainment method." Neurology 58, no. 12 (2002): 1820–25. http://dx.doi.org/10.1212/wnl.58.12.1820.

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Jung, Ho Je, and Jung Hyun Kim. "Novel piezo driven motion amplified stage." International Journal of Precision Engineering and Manufacturing 15, no. 10 (2014): 2141–47. http://dx.doi.org/10.1007/s12541-014-0574-8.

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Moore, R. G., A. K. Brown, C. M. Miller, et al. "Utility of a novel serum tumor biomarker HE4 in patients with uterine cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5036. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5036.

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5036 Background: Approximately 40,880 new cases of uterine cancer are diagnosed in the U.S. annually resulting in 7,310 deaths. Uterine cancer is surgically staged and 75% of patients present with stage I disease. Patients with stage I tumors with intermediate to high risk factors have a recurrence rate of 20 to 30%. Serum CA125 is elevated in 75% of patients with advanced stage disease and in only 17% of patients with early stage disease. The use of CA125 for the detection of recurrent disease is limited at best. Only 25% of patients with asymptomatic recurrent disease have an elevated CA125. A better marker indicating early recurrent disease is needed. The objective of this study was to examine the value of a novel serum tumor marker HE4 in endometrial cancer. Methods: Serum samples from two prospective IRB approved studies at two institutions were analyzed to compare HE4 with CA125 in patients who had surgical staging for uterine cancer. Normal controls were obtained from healthy patients. Informed consent was obtained from all patients and blood samples were drawn pre-operatively. HE4 and CA125 levels were determined using assays from Fujirebio Diagnostic Inc. ROC curves were constructed for each tumor marker and the sensitivity at a set specificity of 95% was determined. Results: Serum from 156 controls and 233 patients with surgically staged endometrial cancer; (151 stage I, 21 stage II, 47 stage III and 14 stage IV) were examined. The area under the ROC curves (ROC-AUC) for HE4 and CA125 were determined and compared ( Table1 ). At 95% specificity, the sensitivity for differentiation of controls versus all stages was 44.9% for HE4 compared to 25.2% for CA125 (p = 0.0001). For stage I cases, HE4 showed an improvement in the sensitivity of 20.5% compared to CA125 (37.1% vs 16.6%, p = 0.0001). Conclusions: HE4 is elevated in all stages of endometrial cancer and has a greater sensitivity for discrimination from normal controls compared to CA125. As well, HE4 is elevated in early stage endometrial cancer and should be investigated as a marker for early recurrent disease. [Table: see text] [Table: see text]

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Efstratiadis, Georgios, Konstantinos Koskinas, and Efstathios Pagourelias. "Coronary calcification in patients with end-stage renal disease: a novel endocrine disorder?" HORMONES 6, no. 2 (2007): 120–31. http://dx.doi.org/10.14310/horm.2002.111108.

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Saif, Muhammad Wasif. "Advanced stage pancreatic cancer: novel therapeutic options." Expert Review of Clinical Pharmacology 7, no. 4 (2014): 487–98. http://dx.doi.org/10.1586/17512433.2014.910451.

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Matos, Joana, Filipa P. da Cruz, Élia Cabrita, et al. "Novel Potent Metallocenes against Liver Stage Malaria." Antimicrobial Agents and Chemotherapy 56, no. 3 (2011): 1564–70. http://dx.doi.org/10.1128/aac.05345-11.

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ABSTRACTNovel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malariain vitroand host-vector transmissionin vivo. Both transmission-blocking and blood-schizontocidal activities of the parent drug were conserved only in primacenes bearing a basic aliphatic amine group. Liver stage activity did not require this structural feature, and all metallocenes tested were comparable to or better than primaquine in this regard. Remarkably, the replacement of primaquine's aliphatic chain by hexylferrocene, as in compound 7, led to a ∼45-fold-higher level activity against liver stage parasitemia than that of primaquine.

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Rezaei, Mercedeh J., John R. Woodward, Julia Ramírez, and Patricia Munroe. "A Novel Two-Stage Heart Arrhythmia Ensemble Classifier." Computers 10, no. 5 (2021): 60. http://dx.doi.org/10.3390/computers10050060.

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Atrial fibrillation (AF) and ventricular arrhythmia (Arr) are among the most common and fatal cardiac arrhythmias in the world. Electrocardiogram (ECG) data, collected as part of the UK Biobank, represents an opportunity for analysis and classification of these two diseases in the UK. The main objective of our study is to investigate a two-stage model for the classification of individuals with AF and Arr in the UK Biobank dataset. The current literature addresses heart arrhythmia classification very extensively. However, the data used by most researchers lack enough instances of these common diseases. Moreover, by proposing the two-stage model and separation of normal and abnormal cases, we have improved the performance of the classifiers in detection of each specific disease. Our approach consists of two stages of classification. In the first stage, features of the ECG input are classified into two main classes: normal and abnormal. At the second stage, the features of the ECG are further categorised as abnormal and further classified into two diseases of AF and Arr. A diverse set of ECG features such as the QRS duration, PR interval and RR interval, as well as covariates such as sex, BMI, age and other factors, are used in the modelling process. For both stages, we use the XGBoost Classifier algorithm. The healthy population present in the data, has been undersampled to tackle the class imbalance present in the data. This technique has been applied and evaluated using an ECG dataset from the UKBioBank ECG taken at rest repository. The main results of our paper are as follows: The classification performance for the proposed approach has been measured using F1 score, Sensitivity (Recall) and Specificity (Precision). The results of the proposed system are 87.22%, 88.55% and 85.95%, for average F1 Score, average sensitivity and average specificity, respectively. Contribution and significance: The performance level indicates that automatic detection of AF and Arr in participants present in the UK Biobank is more precise and efficient if done in a two-stage manner. Automatic detection and classification of AF and Arr individuals this way would mean early diagnosis and prevention of more serious consequences later in their lives.

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Siddiqui, Sabina, C. Todd Bruker, Daniel P. Kestler, et al. "Odontogenic Ameloblast Associated Protein as a Novel Biomarker for Human Breast Cancer." American Surgeon 75, no. 9 (2009): 769–75. http://dx.doi.org/10.1177/000313480907500906.

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Odontogenic Ameloblast Associated Protein (ODAM) is a protein isolated in ameloblasts during odontogenesis. ODAM expression was identified in breast cancer, but its significance remains unknown. The purpose of this study is to determine if ODAM expression can serve as a prognostic marker and provide information regarding treatment in human breast cancer. Breast cancer patients were identified from our tumor registry from 1993 to 2003. Archived breast cancer tissue from 243 patients (stage 0 = 53, stage I = 51, stage II = 53, stage III = 47, stage IV = 39) was stained using monoclonal antibody for ODAM. Presence or absence of immunostaining was correlated with stage, histologic grade, response to chemotherapy, and survival using χ2 and logistic regression analyses. Tumor nuclear staining for ODAM increased with increasing group stage ( P < 0.001). Staining for ODAM did not correlate with histologic grade or chemotherapy ( P = 0.558, P = 0.093). Improved outcomes within each stage were noted with ODAM staining, statistically significant for stages 0, I, and II ( P < 0.001, P = 0.003, P = 0.003) and underpowered for stages III and IV ( P = 0.724, P = 0.059). Survival benefit associated with tumor nuclear staining increased with advancing stage ( P < 0.001). These results show that ODAM predicts survival in breast cancer. Research is ongoing to determine ODAM's clinical utility and role in carcinogenesis.

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Dissertations / Theses on the topic "Novel on stage"

1

Douglas, Alexander D. "Developing novel blood-stage malaria vaccines." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:7ca728f5-6b5e-4f59-ae4b-dd81c8d9e2e8.

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Natural exposure to Plasmodium falciparum’s asexual blood-stage results in protection against severe disease, but no vaccine using the widely-studied blood-stage antigens apical membrane antigen 1 (AMA1) or merozoite surface protein 1 (MSP1) has proven convincingly protective in clinical trials. Challenges include antigenic polymorphism, the apparent requirement for exceptionally high antibody concentrations for protection, and clinical-grade production of conformationally-accurate recombinant protein antigens followed by formulation with a human-compatible adjuvant. This thesis describes the generation of viral-vectored vaccines targeting ten less-studied blood-stage antigens, focusing upon antigens implicated in erythrocyte invasion. These vaccines were immunogenic in mice and rabbits. The rabbit antibodies raised were functionally active in the in vitro assay of parasite growth inhibitory activity (GIA). GIA with antibodies against one antigen, RH5, exceeded that achieved with antibodies against the ‘gold standard’ AMA1 or MSP1 antigens. This antigen’s amino acid sequence is relatively conserved between parasite strains. Importantly, and unlike anti-AMA1 and MSP1 antibodies, the GIA effects transcend genetically diverse strains. It was hypothesised that blockade of the interaction of RH5 with its receptor basigin was likely to be a mechanism of action of anti-RH5 antibodies. Vaccine-induced polyclonal anti-RH5 serum was found to be capable of blocking this interaction, as well as merozoite attachment to erythrocytes. A panel of RH5-specific monoclonal antibodies were raised: those which block the RH5-receptor interaction were capable of neutralising parasites. Minimal linear epitopes recognised by these antibodies were mapped, and are likely to be within or close to RH5’s receptor binding site. These data support prompt clinical testing of RH5-based vaccines, and shed light upon the mechanism of action of anti-RH5 antibodies. However substantial challenges remain in establishing whether this antigen, selected on the basis of the in vitro assay of GIA, will be capable of achieving in vivo protection against P. falciparum. Further work presented in this thesis addresses the use of quantitative PCR data to assess blood-stage vaccine efficacy in experimental human challenge with P. falciparum, and the use of surface plasmon resonance to establish more detailed characterisation of vaccine-induced antibody responses. Finally, the results of P. falciparum challenge of RH5-vaccinated Aotus nancymaae non-human primates are presented.

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Leake, Christy. "Bitterroot Landing: An Adaptation from Novel to Stage." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1262.

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My thesis explores the process involved in adapting Sheri Reynolds' novel, Bitterroot Landing, into a stage play. During the adaptation process I faced numerous challenges, including structural issues, expanding or changing dialogue, omitting or melding scenes and characters, and dealing with the serious themes of incest and sexual abuse. This thesis describes these challenges and the steps I took to overcome them.

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Al-Ghamdi, Ahmed. "Development of a novel three stage distillation system." Thesis, University of Surrey, 2009. http://epubs.surrey.ac.uk/843291/.

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Water shortage is a global problem, which requires a global solution. Desalination technologies, whether thermal or membrane processes, are having practical limitations, which result in high operating and capital costs. The thermal desalination process, namely Multi-Stage Flash (M.S.F.) distillation, is still the most commonly used distillation method, especially in the Middle East. However, the MSF units are generally large-scale and very sophisticated, which require expertise to perform regular technical control and servicing. The aim of the present study is the development of a cost-effective with easy operation distillation system, to satisfy the basic water needs in remote areas in developing countries. A novel small scale three-stage compact distillation system has been designed, constructed, installed and commissioned in a pilot plant study at the University of Surrey. The study involved both theoretical experimental investigations as well as economical analysis. An extensive experimental programme were carried to study the effect of a number of parameters including increasing the heat input, heater temperature and the number of chambers (stages) on the distillate rate as well as the water product cost. The results have shown that: Increasing the number of chambers, heat input and heater temperature have lead to improvement in both the distillate and the production rate; Increasing the number of chambers has increased both the capital and running costs but reduced the specific energy consumption, as well as the unit cost of the produced water; The water production cost decreased by about 13.0% and 28.0 % when the numbers of chambers were increased to two and three chambers respectively, The integration of the system with solar energy source is expected to provide a lower energy cost, which would reduce the final product cost. While the water production cost is estimated to be increased when the system integrated with the fossil fuel as energy source due to increase the oil price during the year of this study.

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Gebauer, Denis. "A novel view on the early stage of crystallization." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/1981/.

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This thesis provides a novel view on the early stage of crystallization utilizing calcium carbonate as a model system. Calcium carbonate is of great economical, scientific and ecological importance, because it is a major part of water hardness, the most abundant Biomineral and forms huge amounts of geological sediments thus binding large amounts of carbon dioxide. The primary experiments base on the evolution of supersaturation via slow addition of dilute calcium chloride solution into dilute carbonate buffer. The time-dependent measurement of the Ca2+ potential and concurrent pH = constant titration facilitate the calculation of the amount of calcium and carbonate ions bound in pre-nucleation stage clusters, which have never been detected experimentally so far, and in the new phase after nucleation, respectively. Analytical Ultracentrifugation independently proves the existence of pre-nucleation stage clusters, and shows that the clusters forming at pH = 9.00 have a proximately time-averaged size of altogether 70 calcium and carbonate ions. Both experiments show that pre-nucleation stage cluster formation can be described by means of equilibrium thermodynamics. Effectively, the cluster formation equilibrium is physico-chemically characterized by means of a multiple-binding equilibrium of calcium ions to a ‘lattice’ of carbonate ions. The evaluation gives GIBBS standard energy for the formation of calcium/carbonate ion pairs in clusters, which exhibits a maximal value of approximately 17.2 kJ mol^-1 at pH = 9.75 and relates to a minimal binding strength in clusters at this pH-value. Nucleated calcium carbonate particles are amorphous at first and subsequently become crystalline. At high binding strength in clusters, only calcite (the thermodynamically stable polymorph) is finally obtained, while with decreasing binding strength in clusters, vaterite (the thermodynamically least stable polymorph) and presumably aragonite (the thermodynamically intermediate stable polymorph) are obtained additionally. Concurrently, two different solubility products of nucleated amorphous calcium carbonate (ACC) are detected at low binding strength and high binding strength in clusters (ACC I 3.1EE-8 M^2, ACC II 3.8EE-8 M^2), respectively, indicating the precipitation of at least two different ACC species, while the clusters provide the precursor species of ACC. It is proximate that ACC I may relate to calcitic ACC –i.e. ACC exhibiting short range order similar to the long range order of calcite and that ACC II may relate to vateritic ACC, which will subsequently transform into the particular crystalline polymorph as discussed in the literature, respectively. Detailed analysis of nucleated particles forming at minimal binding strength in clusters (pH = 9.75) by means of SEM, TEM, WAXS and light microscopy shows that predominantly vaterite with traces of calcite forms. The crystalline particles of early stages are composed of nano-crystallites of approximately 5 to 10 nm size, respectively, which are aligned in high mutual order as in mesocrystals. The analyses of precipitation at pH = 9.75 in presence of additives –polyacrylic acid (pAA) as a model compound for scale inhibitors and peptides exhibiting calcium carbonate binding affinity as model compounds for crystal modifiers- shows that ACC I and ACC II are precipitated in parallel: pAA stabilizes ACC II particles against crystallization leading to their dissolution for the benefit of crystals that form from ACC I and exclusively calcite is finally obtained. Concurrently, the peptide additives analogously inhibit the formation of calcite and exclusively vaterite is finally obtained in case of one of the peptide additives. These findings show that classical nucleation theory is hardly applicable for the nucleation of calcium carbonate. The metastable system is stabilized remarkably due to cluster formation, while clusters forming by means of equilibrium thermodynamics are the nucleation relevant species and not ions. Most likely, the concept of cluster formation is a common phenomenon occurring during the precipitation of hardly soluble compounds as qualitatively shown for calcium oxalate and calcium phosphate. This finding is important for the fundamental understanding of crystallization and nucleation-inhibition and modification by additives with impact on materials of huge scientific and industrial importance as well as for better understanding of the mass transport in crystallization. It can provide a novel basis for simulation and modelling approaches. New mechanisms of scale formation in Bio- and Geomineralization and also in scale inhibition on the basis of the newly reported reaction channel need to be considered.<br>Die vorliegende Arbeit zeichnet ein neuartiges Bild der frühen Kristallisationsphase von Calciumcarbonat. Calciumcarbonat hat als Hauptbestandteil der Wasserhärte und als weit verbreitetes Biomineral und Geomineral, das als Sediment in den Ozeanen große Mengen Kohlendioxid bindet, große Bedeutung. Die grundlegenden Experimente basieren auf der sehr langsamen Einstellung von Übersättigung, die durch langsame Zugabe verdünnter Calciumlösung in verdünnten Carbonatpuffer erreicht wird. Zeitabhängige Messung des Ca2+ Potentials bei gleichzeitiger pH = konstant Titration zeigt, dass zeitgemittelt vor der Nukleation gleiche Stoffmengen von Calcium- und Carbonat Ionen in Clustern gebunden sind, die bis jetzt noch nicht experimentell nachgewiesen werden konnten. Analytische Ultrazentrifugation belegt unabhängig die Existenz der Cluster, und es zeigt sich, dass sich die bei pH = 9,00 bildenden Cluster zeitgemittelt aus insgesamt etwa 70 Calcium und Carbonat Ionen bestehen. Die Experimente weisen darauf hin, dass sich die Clusterbildung auf der Grundlage von Gleichgewichtsthermodynamik beschreiben lässt. Ein multiples Bindungsgleichgewichtsmodell ermöglicht die Bestimmung der freien Standard Reaktionsenthalpie für die Bildung von Calcium/Carbonat Ionenpaaren in den Clustern, die ein Maß für die Bindungsstärke in Clustern darstellt. Die Bindungsstärke weist ein Minimum bei pH = 9,75 auf, und es zeigt sich, dass außerhalb dieses Minimums amorphes Calciumcarbonat ausfällt, das sich letztendlich in Calcit (das thermodynamisch stabile Calciumcarbonat Polymorph) umwandelt, während im Minimum und in der Nähe des Minimums amorphes Calciumcarbonat ausfällt, das sich letztendlich hauptsächlich in Vaterit (das thermodynamisch am wenigsten stabile Polymorph), Calcit und möglicherweise Spuren von Aragonit (das Polymorph mittlerer Stabilität) umwandelt. Gleichzeitig treten zwei unterschiedliche Löslichkeitsprodukte für das bei hoher und niedriger Bindungsstärke in Clustern ausgefällte, amorphe Calciumcarbonat auf (ACC I 3,1EE-8 M^2, ACC II 3,8EE-8 M^2). Das zeigt, dass die sich vor der Nukleation bildenden Cluster Vorläuferspezies (Precursor) des ausgefällten, amorphen Calciumcarbonats darstellen, wobei ACC I in der Literatur diskutiertem, calcitischem ACC entsprechen und ACC II vateritischem Calcit entsprechen kann. Eine detaillierte SEM, TEM, WAXS und Lichtmikroskopie Untersuchung der bei minimaler Bindungsstärke in Clustern (pH = 9,75) ausgefällten Partikel zeigt, dass sich hauptsächlich Vaterit mit Spuren von Calcit und möglicherweise Aragonit bildet. Die sich früh bildenden, kristallinen Partikel sind jeweils aus nano-Kristalliten von etwa 5 bis 10 nm Größe aufgebaut, die wie in Mesokristallen eine hohe wechselseitige Ordnung aufweisen. Die Untersuchung der frühen Kristallisation in Gegenwart von Additiven wurde ebenfalls bei minimaler Bindungsstärke in Clustern durchgeführt. Als Additive wurden Polyacrylsäure (PAA) als Beispiel für einen Hemmstoff gegen die Bildung von Verkalkungen und drei Peptide, die Bindungsaffinität zu Calciumcarbonat zeigen, als Beispiel für Kristallisations-Modifikatoren untersucht. Die Analyse zeigt, dass ACC I und ACC II parallel ausfallen; pAA stabilisiert ACC II gegenüber Kristallisation und führt dazu, dass es sich zugunsten von Kristallen, die sich aus ACC I bilden, auflöst, wobei letztendlich reines Calcit erhalten wird. Die Peptide hingegen hemmen die Bildung von Calcit in analoger Weise, wobei in einem Fall letztendlich reines Vaterit entsteht. Die Ergebnisse zeigen, dass die klassische Nukleationstheorie auf die Nukleation von Calciumcarbonat kaum anwendbar ist. Das metastabile System wird durch die Clusterbildung deutlich stabilisiert, und nicht Ionen, sondern Cluster sind die relevanten Spezies in der Nukleation. Wahrscheinlich ist das gefundene Konzept der Clusterbildung ein allgemeines Phänomen, das während der Kristallisation aller schwer löslichen Substanzen auftritt, da es auch für Calciumoxalat und Calciumphosphat qualitativ gezeigt werden konnte. Das Ergebnis ist wichtig für das fundamentale Verständnis der Nukleation, von Nukleationshemmung und der Modifikation von Kristallen mit Auswirkungen auf Materialen von großer industrieller und auch wissenschaftlicher Bedeutung. Ferner gibt es einen Hinweis, wie Masse während der Kristallisation –auch in Lebewesen transportiert werden kann und es kann einen neuen Ansatz für Kristallisationssimulationen liefern. Auf der Basis dieses neuartigen Reaktionskanals müssen neue Kristallisations-Mechanismen in Bio- und Geomineralization in Betracht gezogen werden.

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Alce, Timothy Mark. "Characterisation of a novel stage-specific protein from Leishmania major." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285161.

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Nicholls, M. P. "Development and performance characterisation of a novel gas-liquid contacting stage." Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313507.

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Salman, Ahmed Mahmoud Ahmed A. "Assessment of novel liver-stage vaccines using transgenic rodent malaria parasites." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8c0e9338-3f33-4c83-b673-c17906ca1e38.

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Malone, Paul Matthew. "Starring Joseph K, four stage adaptations of Franz Kafka's novel The trial." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25107.pdf.

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Hunnicutt, Leigh Anne. "Investigating late stage biopharmaceutical product loss using novel analytical and process technology." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43837.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division; in conjunction with the Leaders for Manufacturing Program at MIT, 2008.<br>MIT Institute Archives copy: pages, 85-86, 87-88, 89-90 bound in reverse order.<br>Includes bibliographical references (p. 79-83).<br>The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments while creating a host of challenges in the discovery, development and manufacture of these products. Protein aggregation is one of the challenges currently limiting the ability to bring new biopharmaceutical products into the market and to manufacture existing commercial products. The mechanisms of aggregation and subsequent particle formation are highly complex, incompletely understood, and difficult to measure quantitatively with currently available analytical tools. Aggregates, and their effect on product appearance, may compromise value to the patient (bioavailability, dose, therapeutic activity and immunogenicity) as well as value to the company (yield loss and performance in a competitive marketplace) and are therefore tightly regulated. This thesis is intended to explore the problem of protein particles through two main avenues: meeting current regulatory criteria and influencing future regulation. Process changes, analytical characterization, and organizational improvements are each addressed to achieve that goal. An experiment was designed and completed to jointly examine (1) changes to manufacturing processes using novel filtration applications intended to reduce or remove protein particles from solution and (2) analytical tools for improved characterization. Organizational dynamics and resource allocation add an extra layer of complexity and are discussed in relation to leveraging knowledge regarding particles.<br>(cont.) Additionally, three objectives are established to influence the direction of future regulation: the need for improved characterization, industry collaboration and a healthy interface with regulatory bodies.<br>by Leigh Anne Hunnicutt.<br>S.M.<br>M.B.A.

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Saggini, Francesca. "The transforming muses : stage appropriations of the Gothic novel in the 1790s." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1473/.

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This thesis offers a theoretically-aware discussion of the stage appropriations of Gothic novels and dramas in the 1790. Works discussed in detail include: *The Monk*, *The Romance of the Forest*, *The Castle Spectre* and their adaptations, re-writings and afterlives. The author examines many intersemiotic practices in the above works as well as in several others, drawing her examples from the whole Georgian period; she also explains the signifying function of costuming, lighting, music and special effects in Gothic. The concepts of intertheatricality and infratheatricality, and their relavance to Gothic are addressed in order to attempt a new definition of the genre.

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Books on the topic "Novel on stage"

1

Ralph, Compton, and Copyright Paperback Collection (Library of Congress), eds. Ralph Compton's runaway stage: A novel. Signet, 2002.

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Woelfle, Gretchen. All the world's a stage: A novel in five acts. Holiday House, 2011.

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Mody, Jehangir R. P. All the world's a stage: A biographical novel on William Shakespeare. Lion Lithographic & Printing P, 1988.

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War horse: Adapted for the stage from the novel by Michael Morpurgo. Faber and Faber, 2007.

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Edward, Marston. The silent woman: [a novel]. St. Martin's Press, 1994.

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Skal, David J. Hollywood gothic: The tangled web of Dracula from novel to stage to screen. Faber and Faber, 2004.

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Skal, David J. Hollywood gothic: The tangled web of Dracula from novel to stage to screen. Deutsch, 1992.

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Skal, David J. Hollywood gothic: The tangled web of Dracula from novel to stage to screen. Norton, 1990.

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Goncharov, Ivan Aleksandrovich. An ordinary story: Including the stage adaptation of the novel by Viktor Rozov. Ardis, 1994.

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1873-1947, Cather Willa, ed. My Antonia: A play for the stage ; adapted from Willa Cather's novel My Antonia. Samuel French, 1994.

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Book chapters on the topic "Novel on stage"

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Tierney-Hynes, Rebecca. "Behn: Romance from the Stage to the Letter." In Novel Minds. Palgrave Macmillan UK, 2012. http://dx.doi.org/10.1057/9781137033291_3.

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González, S. A., F. Guerrero, and E. M. Spinelli. "Novel Single-Stage-Switching Neuromuscular Stimulator." In VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paraná, Argentina 29, 30 & 31 October 2014. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13117-7_4.

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Kirkconnell, C. S., K. D. Price, M. C. Barr, and J. T. Russo. "A Novel Multi-Stage Expander Concept." In Cryocoolers 11. Springer US, 2002. http://dx.doi.org/10.1007/0-306-47112-4_34.

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Miller, Renata Kobetts. "Imagined Audiences: The Novelist and the Stage." In A Companion to the Victorian Novel. Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470996324.ch13.

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Burke, Edward J., and Christopher Parker. "Novel HeartMate Cardiac Assist Systems (Thoratec)." In Mechanical Circulatory Support in End-Stage Heart Failure. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-43383-7_52.

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Abdullah, Muhammad Faizal, Shahid Iqbal, and Dahaman Ishak. "A Novel Bidirectional Two-Stage Inverter Based UPS System." In 9th International Conference on Robotic, Vision, Signal Processing and Power Applications. Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1721-6_90.

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Evans, Hannah, Catherine Pennington, Colm Jordan, and Claire Foster. "Mapping a Nation’s Landslides: A Novel Multi-Stage Methodology." In Landslide Science and Practice. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-31325-7_2.

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Nguyen, Tien Thanh, Alan Wee-Chung Liew, Minh Toan Tran, Thi Thu Thuy Nguyen, and Mai Phuong Nguyen. "Fusion of Classifiers Based on a Novel 2-Stage Model." In Communications in Computer and Information Science. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-45652-1_7.

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Hsu, Ting-Chia, Yea-Shuan Huang, and Fang-Hsuan Cheng. "A Novel ASM-Based Two-Stage Facial Landmark Detection Method." In Advances in Multimedia Information Processing - PCM 2010. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15696-0_49.

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Xu, Jianfeng, Lixu Gu, Xiahai Zhuang, and Terry Peters. "A Novel Multi-stage 3D Medical Image Segmentation: Methodology and Validation." In Computational Intelligence and Security. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11596448_131.

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Conference papers on the topic "Novel on stage"

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Bliznuks, Dmitrijs, Alexey Lihachev, Janis Liepins, et al. "Automated microorganisms activity detection on the early growth stage using artificial neural networks." In Novel Biophotonics Techniques and Applications, edited by Arjen Amelink and Seemantini K. Nadkarni. SPIE, 2019. http://dx.doi.org/10.1117/12.2527193.

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Hu, Bihe, and Jonathon Q. Brown. "Optimization of Optical Sectioning Performance in Thick Tissue Imaging with Stage-Scanning Inverted Selective Plane Illumination Microscopy (iSPIM)." In Novel Techniques in Microscopy. OSA, 2017. http://dx.doi.org/10.1364/ntm.2017.ntu1c.3.

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Gautam, Vasav, Ashok Kumar, and Parthasarathi Sensarma. "A novel single stage, transformerless PV inverter." In 2014 IEEE International Conference on Industrial Technology (ICIT). IEEE, 2014. http://dx.doi.org/10.1109/icit.2014.6894951.

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Zheng, Jinchuan, Aurelio Salton, and Minyue Fu. "A novel rotary dual-stage actuator positioner." In 2009 Joint 48th IEEE Conference on Decision and Control (CDC) and 28th Chinese Control Conference (CCC 2009). IEEE, 2009. http://dx.doi.org/10.1109/cdc.2009.5400199.

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Nithin, N. M., K. Muhammedali Shafeeque, and S. Sheik Mohammed. "A Novel One Stage Buck-Boost Inverter." In 2019 IEEE International Conference on Intelligent Techniques in Control, Optimization and Signal Processing (INCOS). IEEE, 2019. http://dx.doi.org/10.1109/incos45849.2019.8951372.

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Jing, Qu, and Tiejun Lv. "Novel Two-Stage Synchronization for UWB System." In The Third Advanced International Conference on Telecommunications (AICT'07. IEEE, 2007. http://dx.doi.org/10.1109/aict.2007.32.

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Wu, Li-Ming, and Yu-Ming Yeh. "A novel single stage photovoltaic energy converter." In 2009 International Conference on Power Electronics and Drive Systems (PEDS 2009). IEEE, 2009. http://dx.doi.org/10.1109/peds.2009.5385735.

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zhu, xiaotao, wei hong, ningfeng bai, and xiaohan sun. "A multi-stage high resolution sub-wavelength arrayed waveguide grating." In Sixth Symposium on Novel Photoelectronic Detection Technology and Application, edited by Huilin Jiang and Junhao Chu. SPIE, 2020. http://dx.doi.org/10.1117/12.2565060.

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Tian, Yanling, Kangkang Lu, Fujun Wang, et al. "A Novel XY Nano Positioning Stage with a Three Stage Motion Amplification Mechanism." In 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). IEEE, 2019. http://dx.doi.org/10.1109/3m-nano46308.2019.8947353.

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Yadav, M. S., D. C. Dumka, Ramesh C. Ramola, Subodh Johri, Harshad S. Kothari, and Babu R. Singh. "Design optimization of three-stage GaAs monolithic optical amplifier using SPICE." In Physical Concepts of Materials for Novel Optoelectronic Device Applications, edited by Manijeh Razeghi. SPIE, 1991. http://dx.doi.org/10.1117/12.24470.

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Reports on the topic "Novel on stage"

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Basol, B. M., V. K. Kapur, A. Halani, and C. Leidholm. Novel Two-Stage Selenization Methods for Fabrication of Thin-Film CIS Cells and Submodules: Annual Subcontract Report, 25 March 1992 - 28 February 1993. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10192593.

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Basol, B., V. Kapur, A. Halani, C. Leidholm, and A. Minnick. Novel two-stage selenization methods for fabrication of thin-film CIS cells and submodules. Final subcontract report, March 1, 1993--March 31, 1995. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/70753.

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Chen, Chonglin, Patrick Nash, Jian Liu, and Gregory Collins. Novel Low Temperature Solid State Fuel Cells. Office of Scientific and Technical Information (OSTI), 2010. http://dx.doi.org/10.2172/1083746.

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Stroscio, Michael A. Solid-State Dynamics in Novel Semiconductor Nanostructures. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada271249.

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Crespi, Vincent Henry. Superconducting and normal-state properties of novel materials. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/58057.

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Grinfeld, M. A. Operational Equations of State. 1. A Novel Equation of State for Hydrocode. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada553223.

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Lukin, Mikhail. Novel Techniques for Quantum State Manipulation in Mesoscopic Systems. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada441535.

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Manginell, Ronald P., and Kent B. Pfeifer. Novel Materials and Devices for Solid-State Neutron Detection. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1226121.

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Pfeifer, Kent B., Komandoor Achyuthan, Matthew Allen, Michele L. Baca Denton, Michael P. Siegal, and Ronald P. Manginell. Novel Materials and Devices for Solid-State Neutron Detection. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1562846.

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Averin, D. V., S. Han, K. K. Likharev, J. E. Lukens, and V. K. Semenov. Novel Approaches to Quantum Computation Using Solid State Qubits. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada477137.

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