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Relevant bibliographies by topics / Novel Potent Enzyme Inhibitors

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Academic literature on the topic 'Novel Potent Enzyme Inhibitors'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Novel Potent Enzyme Inhibitors"

1

Yamali, Cem, Halise Inci Gul, Tahir Cakir, Yeliz Demir, and Ilhami Gulcin. "Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors." Letters in Drug Design & Discovery 17, no. 10 (2020): 1283–92. http://dx.doi.org/10.2174/1570180817999200520123510.

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Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors. Objective: In this study, novel Mannich bases, 1-(3,5-bis-aminomethyl-4-hydroxyphenyl)-3-(4- substitutedphenyl)-2-propen-1-ones (1-9), were de

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Pilkington, Leung, and Barker. "Development of Novel, Potent Phosphatidyl–Choline-Specific Phospholipase C Inhibitors." Proceedings 22, no. 1 (2019): 67. http://dx.doi.org/10.3390/proceedings2019022067.

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The phosphatidyl–choline-specific phospholipase C (PC-PLC) enzyme has been shown to be an important enzyme involved in various cell-signaling processes. Furthermore, PC-PLC has been shown to be upregulated in various cancer cell lines, thereby presenting itself as a potential anti-cancer therapeutic target. Current PC-PLC inhibitors, including the literature standard inhibitor D609 possess characteristics making them unsuitable for clinical use. We have discovered a new class of potent PC-PLC inhibitors with much improved activity and drug-like properties than D609. The synthesis and SAR study

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Jeng, Arco Y., Paul Mulder, Aij-Lie Kwan, and Bruno Battistini. "Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications." Canadian Journal of Physiology and Pharmacology 80, no. 5 (2002): 440–49. http://dx.doi.org/10.1139/y02-025.

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Endothelins (ETs) are potent vasoconstrictors, promitogens, and inflammatory mediators. They have been implicated in the pathogenesis of various cardiovascular, renal, pulmonary, and central nervous system diseases. Since the final step of the biosynthesis of ETs is catalyzed by a family of endothelin-converting enzymes (ECEs), inhibitors of these enzymes may represent novel therapeutic agents. Currently, seven isoforms of these metalloproteases have been identified; they all share a significant amino acid sequence identity with neutral endopeptidase 24.11 (NEP), another metalloprotease. There

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Hassan, Sidra, Pervaiz Ali Channar, Fayaz Ali Larik, et al. "Synthesis of novel ( E )-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors." Royal Society Open Science 5, no. 9 (2018): 180837. http://dx.doi.org/10.1098/rsos.180837.

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Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling. Their upregulation results in various disease conditions, for example, inflammation, hypoxia and cancer. Therefore, efforts have been made to synthesize potent and selective inhibitors of e5′NT. Here we have synthesized, characterized and evaluated six thiazole derivatives (3a–3f) as potent e5′NT inhibitors. Among all derivatives, the compound ( E )-1-(4-methyl-2-(2-(pyridin-3-ylmethylene)hydrazinyl) thiazol-5-yl)ethanone (3a) exhibited maximu

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Wang, Q. May, Robert B. Johnson, Louis N. Jungheim, Jeffrey D. Cohen, and Elcira C. Villarreal. "Dual Inhibition of Human Rhinovirus 2A and 3C Proteases by Homophthalimides." Antimicrobial Agents and Chemotherapy 42, no. 4 (1998): 916–20. http://dx.doi.org/10.1128/aac.42.4.916.

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ABSTRACT The 2A and 3C proteases encoded by human rhinoviruses (HRVs) are attractive targets for antiviral drug development due to their important roles in viral replication. Homophthalimides were originally identified as inhibitors of rhinovirus 3C protease through our screening effort. Previous studies have indicated that the antiviral activity of certain homophthalimides exceeded their in vitro inhibitory activity against the viral 3C protease, suggesting that an additional mechanism might be involved. Reported here is the identification of homophthalimides as potent inhibitors for another

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Buryska, Tomas, Lukas Daniel, Antonin Kunka, Jan Brezovsky, Jiri Damborsky, and Zbynek Prokop. "Discovery of Novel Haloalkane Dehalogenase Inhibitors." Applied and Environmental Microbiology 82, no. 6 (2016): 1958–65. http://dx.doi.org/10.1128/aem.03916-15.

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ABSTRACTHaloalkane dehalogenases (HLDs) have recently been discovered in a number of bacteria, including symbionts and pathogens of both plants and humans. However, the biological roles of HLDs in these organisms are unclear. The development of efficient HLD inhibitors serving as molecular probes to explore their function would represent an important step toward a better understanding of these interesting enzymes. Here we report the identification of inhibitors for this enzyme family using two different approaches. The first builds on the structures of the enzymes' known substrates and led to

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Hurst, Douglas R., Martin A. Schwartz, Yonghao Jin, et al. "Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors." Biochemical Journal 392, no. 3 (2005): 527–36. http://dx.doi.org/10.1042/bj20050545.

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MT1-MMP (membrane type 1 matrix metalloproteinase, or MMP-14) is a key enzyme in molecular carcinogenesis, tumour-cell growth, invasion and angiogenesis. Novel and potent MMP inhibitors with a mercaptosulphide zinc-binding functionality have been designed and synthesized, and tested against human MT1-MMP and other MMPs. Binding to the MT1-MMP active site was verified by the competitive-inhibition mechanism and stereochemical requirements. MT1-MMP preferred deep P1′ substituents, such as homophenylalanine instead of phenylalanine. Novel inhibitors with a non-prime phthalimido substituent had Ki

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Ma, Ling, Jiajia Wen, Biao Dong, et al. "Design and Evaluation of Novel HIV-1 Protease Inhibitors Containing Phenols or Polyphenols as P2 Ligands with High Activity against DRV-Resistant HIV-1 Variants." International Journal of Molecular Sciences 23, no. 22 (2022): 14178. http://dx.doi.org/10.3390/ijms232214178.

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With the increasing prevalence of drug-resistant variants, novel potent HIV-1 protease inhibitors with broad-spectrum antiviral activity against multidrug-resistant causative viruses are urgently needed. Herein, we designed and synthesized a new series of HIV-1 protease inhibitors with phenols or polyphenols as the P2 ligands and a variety of sulfonamide analogs as the P2′ ligands. A number of these new inhibitors showed superb enzymatic inhibitory activity and antiviral activity. In particular, inhibitors 15d and 15f exhibited potent enzymatic inhibitory activity in the low picomolar range, a

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Khunluck, Tueanjai, Veerapol Kukongviriyapan, Laddawan Senggunprai, Wutthipong Duangarsong, and Auemduan Prawan. "The Inhibition Kinetics and Potential Anti-Migration Activity of NQO1 Inhibitory Coumarins on Cholangiocarcinoma Cells." Integrative Cancer Therapies 18 (December 25, 2018): 153473541882044. http://dx.doi.org/10.1177/1534735418820444.

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Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of NQO1 has been proposed as a potential strategy to improve the efficacy of anticancer drugs in various cancers including CCA. This study investigated novel NQO1 inhibitors and verified the mechanisms of their enzyme inhibition. Among the different chemical classes of natural NQO1 in

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Chu, Ming-Jie, Wei Wang, Zi-Li Ren, et al. "Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents." Molecules 24, no. 7 (2019): 1311. http://dx.doi.org/10.3390/molecules24071311.

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To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the most potent antibacterial activity with Minimum inhibitory concentration (MIC) alues of 4 µg/mL, 2 µg/mL, 4 µg/mL, and 0.5 µg/mL against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella gallinarum, respectively. The in vivo enzyme inhibition assay 4d displayed the most potent topoisomerase II (IC50 = 13.5 µg/mL) and topo

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Dissertations / Theses on the topic "Novel Potent Enzyme Inhibitors"

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Varley, Denise Joyce. "Novel inhibitors of glutamine synthase." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308650.

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Olomola, Temitope Oloruntoba. "Synthesis and evaluation of novel HIV-1 enzyme inhibitors." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1005034.

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This study has involved the design, synthesis and evaluation of novel HIV-1 enzyme inhibitors accessed by synthetic elaboration of Baylis-Hillman adducts. Several series of complex coumarin-AZT and cinnamate ester-AZT conjugates have been prepared, in high yields, by exploiting the click reaction between appropriate Baylis-Hillman derived precursors and azidothymidine (AZT), all of which have been fully characterised using spectroscopic techniques. These conjugates, designed as potential dual-action HIV-1 inhibitors, were tested against the appropriate HIV-1 enzymes, i.e. HIV-1 reverse transcr

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Capicciotti, Chantelle. "The Rational Design of Potent Ice Recrystallization Inhibitors for Use as Novel Cryoprotectants." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30634.

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The development of effective methods to cryopreserve precious cell types has had tremendous impact on regenerative and transfusion medicine. Hematopoietic stem cell (HSC) transplants from cryopreserved umbilical cord blood (UCB) have been used for regenerative medicine therapies to treat conditions including hematological cancers and immodeficiencies. Red blood cell (RBC) cryopreservation in blood banks extends RBC storage time from 42 days (for hypothermic storage) to 10 years and can overcome shortages in blood supplies from the high demand of RBC transfusions. Currently, the most commonly u

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Ekici, Ozlem Dogan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5333.

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Takeuchi, Toshihiko Gray Harry B. Goddard William A. Meade Thomas J. "The electronic structure of distorted porphyins and cobalt schiff base derivatives as novel enzyme inhibitors." Diss., Pasadena, Calif. : California Institute of Technology, 1996. http://resolver.caltech.edu/CaltechTHESIS:11052009-085123252.

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Thesis (Ph. D.)--California Institute of Technology, 1996. UM #9617425.<br>Advisor names found in the Acknowledgments pages of the thesis. Title from home page. Viewed 01/19/2010. Includes bibliographical references.

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Wiencek, Patrick. "Secondary Functions And Novel Inhibitors Of Aminoacyl-Trna Synthetases." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/941.

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The aminoacyl-tRNA synthetases are a family of enzymes involved in the process of translation, more specifically, ligating amino acids to their cognate tRNA molecules. Recent evidence suggests that aminoacyl-tRNA synthetases are capable of aminoacylating proteins, some of which are involved in the autophagy pathway. Here, we test the conditions under which E. coli and human threonyl-tRNA synthetases, as well as hisidyl-tRNA synthetase aminoacylate themselves. These reactions are ATP dependent, stimulated by Mg2+, and are inhibited by increasing cognate tRNA concentrations. These data represent

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Boulton, Sallyanne. "Biological effects of novel poly (adenosine diphosphate ribose) polymerase inhibitors." Thesis, University of Newcastle Upon Tyne, 1995. http://hdl.handle.net/10443/1004.

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Poly(ADP-ribose) polymerase (PADPRP) is a nuclear enzyme with a well documented role in DNA repair. Inhibitors of PADPRP, (e.g. 3' substituted benzamides) potentiate the cytotoxicity of a wide range of antitumour drugs. The results presented in this thesis represent, to the best of my knowledge, the first comprehensive and quantitative assessment of the ability of a range of P ADPRP inhibitors to modulate the cellular responses to damaging agents. Two novel PADPRP inhibitors, 8-hydroxy-2-methyl quinazolin-4(3H)-one (NU1025) and 3,4 dihydro-5-methoxyisoquinolin-1-(2H)-one (PD 128763) were compa

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PRENCIPE, Filippo. "Synthesis and biological evaluation in vitro and in vivo of novel potent anticancer agents affecting tubulin polymerization." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2487939.

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L’attività di ricerca svolta durante i tre anni di dottorato ha avuto come obiettivo la progettazione, la sintesi e l’ottimizzazione di nuovi potenziali agenti antitumorali dotati di attività antiproliferativa e antivascolare che hanno come target biologico i microtubuli, strutture dinamiche cellulari generate dalla polimerizzazione di eterodimeri di α,β tubulina. Il sistema di microtubuli è essenziale per la divisione cellulare, essendo coinvolto nella formazione del fuso mitotico, ed è importante per diversi processi cellulari quali la regolazione della motilità, segnalazione cellulare, secr

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Ekici, Özlem Doğan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04062004-164633/unrestricted/ekici%5Fozlem%5Fd%5F200312%5Fphd.pdf.

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Agarwal, Anil Kumar. "Design and synthesis of novel bacterial enzyme inhibitors as potential antituberculosis agents." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445382.

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Books on the topic "Novel Potent Enzyme Inhibitors"

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Bojidor, Georgiev, and Markovski Sava, eds. Serpins and protein kinase inhibitors: Novel functions, structural features, and molecular mechanisms. Nova Science, 2009.

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Georgiev, Bojidor. Serpins and protein kinase inhibitors: Novel functions, structural features and molecular mechanisms. Nova Science Publishers, 2010.

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AlJaroudi, Wael. Risk Assessment in Acute Coronary Syndromes. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0013.

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Acute coronary syndromes (ACS) include unstable angina pectoris (UAP), non-ST elevation (NSTEMI), and ST elevation acute myocardial infarction (STEMI). Each year, more than 2 million people are hospitalized with ACS in the United States. The initial treatment has evolved over the last few decades from conservative management to early reperfusion therapy. Medical therapy has also significantly changed with the use of newer more potent antiplatelet agents, beta-blockers, angiotensin converting enzyme inhibitors, statins, and anti-anginal drugs, which have resulted in improvement of patient care

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Book chapters on the topic "Novel Potent Enzyme Inhibitors"

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Polat, Hakan, and Yavuz Onur Danacioglu. "Abiraterone Acetate Treatment in Metastatic Prostate Cancer." In Current Management of Metastatic Prostate Cancer. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359142.8.

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Prostate cancer is the frequently presented malignancy in men, and it is expected that nearly 300,000 people will be diagnosed with it in the United States in 2024. Generally, the five-year survival rate is quite positive at 97.5%, but this rate drops to around 30% in cases with advenced disease. Tumors arise from changes in the genetic material of the epithelial cells in the prostate gland and typically appear as adenocarcinomas. Adenocarcinoma of the prostate is found within the gland in a multifocal and heterogeneous manner. Metastases of prostate cancer are hormonally sensitive, the primar

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Penrose, John F., K. Frank Austen, and Bing K. Lam. "LTC4 synthase: A key enzyme in cysteinyl leukotriene formation." In Novel Inhibitors of Leukotrienes. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8703-8_2.

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Haeggström, Jesper Z., and Anders Wetterholm. "Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation." In Novel Inhibitors of Leukotrienes. Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8703-8_3.

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Magolda, Ronald L., William C. Ripka, William Galbraith, Paul R. Johnson, and Marla S. Rudnick. "Novel Synthesis of Potent Site-Specific Phospholipase A2 Inhibitors." In Prostaglandins, Leukotrienes, and Lipoxins. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4946-4_63.

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Leyssen, Pieter, Jacqueline Smadja, Philippe Rasoanaivo, et al. "Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication." In Novel Plant Bioresources. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118460566.ch11.

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Loots, Melanie J., Michael C. Badia, David W. Cushman, et al. "Acyl lysinamido phosphonates: Potent, long-acting inhibitors of angiotensin-converting enzyme." In Peptides. Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_34.

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Gambhir, Lokesh, and Neha Kapoor. "Fungal Enzyme Inhibitors: Potent Repository of Lead Compounds to Curb Cancer." In Fungi Bioactive Metabolites. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-5696-8_13.

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Pandey, Divya, and Kuldeep K. Roy. "Identification of Novel Potent KRASG12D Inhibitors Through Target-Based Virtual Screening." In Global Trends in Health, Technology and Management. Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-031-75457-9_14.

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Brands, B., C. A. Naranjo, J. W. Tighe, R. S. Collis, and E. M. Sellers. "Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats." In Novel Pharmacological Interventions for Alcoholism. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2878-3_45.

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Grupp, L. A., G. Spinosa, and T. Lingham. "Management of Alcohol Consumption with Angiotensin Converting Enzyme Inhibitors: A Review of the Animal Findings." In Novel Pharmacological Interventions for Alcoholism. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2878-3_16.

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Conference papers on the topic "Novel Potent Enzyme Inhibitors"

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Fujita, Hidenori, Yayoi Fujioka, Keiji Ishida, et al. "Abstract 3777: TAS4464, a novel and highly potent NEDD8 activating enzyme (NAE) inhibitor, causes apoptosis of sarcomas via cell cycle dysregulation." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3777.

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Muraoka, Hiromi, Chihoko Yoshimura, Shingo Tsuji та ін. "Abstract 1730: TAS4464, a novel highly potent NEDD8 activating enzyme inhibitor, demonstrates antitumor activity in multiple myeloma through the inactivation of NF-κB pathways". У Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1730.

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Yoshimura, Chihoko, Hiromi Muraoka, Hiroaki Ochiiwa, et al. "Abstract C176: TAS4464, a novel, highly potent, and selective inhibitor of NEDD8 activating enzyme demonstrates sustained target inhibition and antitumor activity in a preclinical model." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c176.

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Muraoka, Hiromi, Chihoko Yoshimura, Shingo Tsuji та ін. "Abstract C177: TAS4464, a novel and highly potent inhibitor of NEDD8 activating enzyme, overcomes insensitivity to BTK, PI3Kδ, and IRAK4 inhibitors in activated B-cell like diffuse large B-cell lymphoma via inactivation of the NF-κB pathway". У Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c177.

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Cvijetić, Ilija, Petar Ristivojević, Maja Krstić-Ristivojević та Dušanka Milojković-Opsenica. "EXPLORING THE POTENTIAL OF Α-ARBUTIN AS THE INHIBITOR OF NEURODEGENERATIVE DISORDERS". У 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.292c.

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Tyrosinase is an enzyme involved in generation of dopamine-quinones, which has an important role in oxidative stress associated with the Parkinson’s disease. It is also a common molecular target for the design of novel anti-melanogenic agents. The inhibition of tyrosinase might be responsible for the experimentally observed intracellular antioxidant activity of α-arbutin. Moreover, intrinsic radical scavenging capacity of α-arbutin should also be considered. The binding mode of α-arbutin into the active site of Bacillus megaterium tyrosinase is predicted using AutoDock Vina 1.1. To map the the

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Zaman, Khair. "Chalcones: As Potent Α-Amylase Enzyme Inhibitors; Synthesis, In Vitro, And In Silico Studies." У International Conference on Biological Research and Applied Science. Jinnah University for Women, Karachi,Pakistan, 2022. http://dx.doi.org/10.37962/ibras/2022/83.

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Wengner, Antje Margret, Gerhard Siemeister, Marcus Koppitz, et al. "Abstract 3090: Novel Mps1 kinase inhibitors with potent anti-tumor activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3090.

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Callery, Patrick S., Wisut Wichitnithad, Elizabeth Borysiewicz, Gregory W. Konat, and Gregory W. Konat. "Abstract 3255: Tetrahydropyridine derivatives: Novel and potent histone demethylase LSD1 inhibitors." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3255.

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Deryagina, V. P., N. I. Ryzhova, L. A. Savluchinskaya, I. S. Golubeva, L. V. Krivosheeva, and K. I. Kirsanov. "eNOS INVOLVEMENT IN CARCINOGENESIS AND PROSPECTS FOR THE USE OF ENZYME INHIBITORS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.310-321.

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The review discusses the literature data and the results of our own research on the role of endothelial NO synthase (eNOS) in carcinogenesis. The antitumor potential of eNOS inhibi-tors and the molecular mechanisms of their action are analyzed.

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Vakkalanka, Swaroop, Meyyappan Muthuppalaniappan, Babu Govindarajulu, et al. "Abstract 1789: Preclinical profile of novel and potent c-Met kinase inhibitors." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1789.

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Reports on the topic "Novel Potent Enzyme Inhibitors"

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Joel, Daniel M., John C. Steffens, and Alfred M. Mayer. Host-Elicited Germination and Mechanism of Penetration in Broomrape (Orobanche Spp.). United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568107.bard.

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Orobanche is an important parasitic weed. For developing novel methods for its control, a thorough understanding of crucial stages of its development is needed. Therefore, the objectives of this project were characterization of Orobanche germination stimulants, analysis of mechanisms of haustorial penetration, and characterization and isolation of penetration enzymes. The first highly potent natural germination stimulant for Orobanche was isolated from sunflower and identified by high-field 1D (1H and 13C), 2D (1H-1H COSY, HMQC, HMBC)-NMR, GC.FT-IR, and GC.MS as costuslactone, a guaiane type s

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Simeonova, Rumiana, Vessela Vitcheva, Ivanka Kostadinova, et al. In Vivo Studies on Novel Potent Acetylcholinesterase Inhibitors with Dual-site Binding for Treatment of Alzheimer’s Disease. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2021. http://dx.doi.org/10.7546/crabs.2021.06.13.

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Blumwald, Eduardo, and Avi Sadka. Sugar and Acid Homeostasis in Citrus Fruit. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697109.bard.

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Citrus fruit quality standards have been determined empirically, depending on species and on the particular growing regions. In general, the TSS (total soluble solids) to total acidity (TA) ratio determines whether citrus fruit can be marketed. Soluble sugars account for most of the TSS during harvest while TA is determined almost solely by the citric acid content, which reaches levels of 1-5% by weight in many cultivated varieties. Acid and sugar homeostasis in the fruit is critical for the management of existing cultivars, the development of new cultivars, the improvement of pre- and post-ha

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