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Dissertations / Theses on the topic 'Novel psychoactive substances (NPSs)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Simonato, Pierluigi. "Evaluating and expanding knowledge and awareness of health professionals on the consumption and adverse consequences of Novel Psychoactive Substances (NPS) through innovative information technologic tools." Thesis, University of Hertfordshire, 2015. http://hdl.handle.net/2299/16557.

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Background: The rapid diffusion of Novel Psychoactive Substances (NPS) constitutes an important challenge in terms of public health and a novelty in clinical settings, where these compounds may lead to erratic symptoms, unascertained effects and multi-intoxication scenarios, especially in emergency situations. The number of NPS available on the illicit drug market is astonishing: official reports suggest the appearance of a new drug every week. NPS may be enlisted in many different families such as synthetic phenethylamines, tryptamines, cathinones, piperazines, ketamine-like compounds, cannab

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2

Freeman, Jodie. "Young people's perceptions of novel psychoactive substances." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621953.

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Novel Psychoactive Substances (NPS) also known as "legal highs" replicate the effects of illegal substances such as ecstasy and cocaine. The most common NPS reported are stimulants and synthetic cannabinoids. Despite the Psychoactive Ban (2016) recent reports identified the UK as having the largest market of NPS use anywhere in Europe. These substances have a short history of consumption and consequently little is known about their effects and health implications. Despite this, the sale of NPS is easily achieved through the internet and street dealers. Increased reports of negative health cons

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3

Ritchie, Joseph. "Novel psychoactive substances : implications for UK drugs policy." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/novel-psychoactive-substances-implications-for-uk-drugs-policy(e54b7355-3ef5-49b6-8090-3f8458e5018a).html.

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In January 2016, the UK Government legislated for the blanket prohibition of 'new psychoactive substances' (NPS), i.e. unregulated substances that were viewed as similar to already controlled drugs. This followed a six-year period over which these substances have, with increasing speed, been scheduled as drugs, while the harms associated with these substances has increased. This thesis critiques policy here in terms of the way 'NPS' has been represented as a problem for policy makers. Drawing on post-structuralist theory and Science and Technology Studies, it seeks to account for first, how an

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4

Loi, Barbara. "Neurochemical and neuropharmacological studies on a range of novel psychoactive substances." Thesis, University of Hertfordshire, 2018. http://hdl.handle.net/2299/21073.

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Introduction: Over recent decades, there has been an increase in the availability and use of Novel Psychoactive Substances (NPS) all over the world. They include several classes of chemicals that mimic the effects of illicit drugs and have been purposefully introduced into the market to circumvent or undermine the purpose of legal regulation. Currently, there is information lacking on the pharmacology of these substances; however, the increasing number of cases and outbreaks of intoxications/deaths is becoming a cause for deepening concern. Multi-disciplinary research in the fields of biology,

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5

Arunotayanun, W. "Chemical and biological studies on natural and synthetic Novel Psychoactive Substances." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1432658/.

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Over the past decade, the availability of novel psychoactive substances (NPS), so called “legal highs”, has been increasing dramatically worldwide. Natural products (NP) and synthetic compounds based on NP are amongst the most commonly offered by online vendors. Most synthetic substances have recently been introduced and very little is known about their chemical and biological properties. In this project, 18 novel synthetic NPS were selected and purchased online. The full chemical characterizations using NMR, ESI-MS, HRMS, IR and UV techniques as well as in vitro neurological assays were carri

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6

Rutherford, Benjamin. "Novel psychoactive substances - Methods for identification, predictive modelling software and an experimental design." Thesis, Rutherford, Benjamin (2017) Novel psychoactive substances - Methods for identification, predictive modelling software and an experimental design. Masters by Research thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/39825/.

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In recent years novel psychoactive substances (NPS) have begun to pose a serious threat to public health and safety. Not only because of their dramatic increase in production and the reported increase of their abuse, but because of their ability to circumvent legislation and the difficulties involved in attempting to identify them. This literature review discusses NPS, the more prevalent classes of NPS, and current methods used for identifying them. The potential for algorithm based predictive modelling software as a technique for identifying NPS will also be investigated.

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7

Jebadurai, Jeshoor Kumar. "Qualitative research of online drug misuse communities with reference to the novel psychoactive substances." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11352.

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Objective: This research aimed at reviewing the information provided by the online drug misuse communities with reference to the available evidence-based literature on the novel psychoactive substances. Methodology: Among hundreds of novel psychoactive substances, four groups (phenethylamines, tryptamines, piperazines and miscellaneous) were selected for the study. Various website drug fora were identified by Google and Yahoo search engines using a set of specific key words. The methods consisted of extracting and analysing qualitative data from the identified website fora. This was also suppl

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8

Seither, Joshua Zolton. "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3823.

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There has been an emergence of novel psychoactive substances (NPS) in forensic casework globally. Although the reported prevalence of these compounds has been relatively low in comparison to traditional drugs of abuse, published case studies suggest that some NPS have significant pharmacological effects that may cause severe impairment and/or death. Because of these effects, it is important that toxicology laboratories have the capability of identifying these compounds to complete a comprehensive toxicological analysis for human performance and post-mortem investigations. Recently, mass spectr

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9

Mohd, Fauzi Fazlin Binti. "In silico target prediction : applications to traditional medicine and novel psychoactive substances and the extension to biological space." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708743.

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10

Eckberg, Melanie N. "Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3923.

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Novel psychoactive substances (NPS) represent a great challenge to toxicologists due to the ability of illicit drug manufacturers to alter NPS chemical structures quickly and with ease to circumvent legislation regulating their use. Each time a new structure is introduced, there is a possibility that it has not been previously recorded in law enforcement or scientific databases. Many toxicology laboratories use targeted analytical methods that rely on libraries of known compounds to identify drugs in samples. However, these libraries do not include large numbers of NPS which could result in no

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11

Garrett, Emma Rachael. "Chemical and morphological investigations of the ontogenetic effects of Novel Psychoactive Substances on forensically important blowfly species (Diptera: Calliphoridae)." Thesis, Keele University, 2018. http://eprints.keele.ac.uk/5134/.

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Post Mortem Interval (PMI) estimation is a key concern of forensic entomology research. Numerous factors are recognized to affect these calculations, and have shown to potentially introduce error, leading to an incorrect time of death estimation. One such acknowledged factor is the presence of drugs and toxins. A range of Novel Psychoactive Substances (NPS), common adulterants and one illegal drug were tested on two blowfly species, of forensic importance, Calliphora vicina and Lucilia sericata (Diptera: Calliphoridae). An artificial diet was used to enable effective delivery of the substances

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12

Michely, Julian Alexander [Verfasser], and Hans [Akademischer Betreuer] Maurer. "Metabolism of tryptamine-derived new psychoactive substances and development of novel screening concepts using hyphenated mass spectrometry / Julian Alexander Michely ; Betreuer: Hans Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/115209520X/34.

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Michely, Julian Alexander Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Metabolism of tryptamine-derived new psychoactive substances and development of novel screening concepts using hyphenated mass spectrometry / Julian Alexander Michely ; Betreuer: Hans Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-ds-269873.

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14

Couto, Rosa Alexandrina de Sousa. "Development and application of an innovative disposable sensor for Novel Psychoactive Substances (NPSs) based on electrochemistry." Doctoral thesis, 2021. https://hdl.handle.net/10216/134054.

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15

Couto, Rosa Alexandrina de Sousa. "Development and application of an innovative disposable sensor for Novel Psychoactive Substances (NPSs) based on electrochemistry." Tese, 2021. https://hdl.handle.net/10216/134054.

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16

Großert, Alessandra. "Elucidation of the molecular mechanism of action of psychoactive substances as novel antidepressants." Doctoral thesis, 2020. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202003312713.

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According to the World Health Organization (WHO) depression is the leading cause of disability worldwide with more than 300 million patients affected. Current antidepressants have a delayed onset of action and moreover, only two-thirds of patients suffering from depressive disorder respond to antidepressant drug treatment. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine offers promising perspectives for the treatment of major depressive disorder. Although ketamine demonstrates rapid and long-lasting effects, even in treatment-resistant patients, to date, the underlying mode of act

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17

CAMUTO, CRISTIAN. "Characterization of the metabolic profile of novel psychoactive substances by a combination of in vitro and in vivo studies and chromatographic-spectrometric techniques." Doctoral thesis, 2019. http://hdl.handle.net/11573/1336448.

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This PhD work is focused on those Novel Psychoactive Substances (NPS) which could exert effects as doping agent in sport competitions. Analysis were carried out at “Laboratorio Antidoping FMSI” of Rome part of laboratories around the world accredited by WADA to conduct human doping control sample analyses. Different substances were selected thorough the years of study, among those NPS with structures and action similar to other compounds already prohibited in sport competitions. The substances of interest were selected according to University of Ferrara department of morphology, surgery and ex

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18

Williams, Michelle. "Development of methods for the detection of novel psychoactive substances in oral fluid." Thesis, 2019. http://hdl.handle.net/1959.13/1407512.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Novel psychoactive substances (NPS) are a group of drugs developed to evade legal and testing authorities whilst producing the effects similar to the drug they mimic. Two large groups of NPS are cathinones and synthetic cannabinoids. Due to the novel nature and rapid evolution of these drugs, testing options have not been available for workplaces wishing to undertake drug testing as part of their safety management program. The existing standards AS/NZS 4308:2008 and AS 4760:2006 only allow for the detection and quantitation of traditional drug

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19

Phung, Erika Dang. "Evaluation of the long-term stability of select phenylacetylindole, cycloalkylindole, quinolinyl, and carboxamide synthetic cannabinoids using LC-MS/MS." Thesis, 2019. https://hdl.handle.net/2144/38697.

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Despite efforts to control synthetic cannabinoids, clandestine manufacturers continue to modify their structures to avoid legal consequences, creating an ever-changing analytical target for forensic laboratories (1). Forensic toxicology laboratories often lack the needed resources or do not have the capabilities to test for these compounds and metabolites, requiring specimens to be submitted to reference laboratories (2). Drug stability can be affected by long storage times, temperature and preservatives (3). Although these factors can be controlled, systematic research is necessary to identif

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20

Syrová, Kateřina. "Akutní účinky nové psychoaktivní látky ze skupiny derivátů fenyletylaminu - animální studie." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-405607.

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Synthetic N-methoxybenzyl ("NBOMe") phenylethylamine derivatives were developed as highly potent agonists for the research of 5-hydroxytryptamine receptors, however they have become available on the black market in the past few years. They are sought by recreational users as "legal LSD", in worse cases the replacement is unsuspected and these substances are a cause of serious intoxication with signs of serotonin toxicity. At this moment, there is very little data available, but their low price, easy access via the internet and legal status make these substances an interesting target for recrea

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