Relevant bibliographies by topics / Novel Pyrazoline Derivatives

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Novel Pyrazoline Derivatives'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Novel Pyrazoline Derivatives"

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Dwivedi, Pratibha, and Dr Alka Pradhan. "Synthesis and Characterization of Various Pyrazolines From Chalcones." International Journal for Research in Applied Science and Engineering Technology 10, no. 5 (2022): 2108–10. http://dx.doi.org/10.22214/ijraset.2022.42656.

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Abstract: Some novel series of pyrazoline derivatives were synthesized from Chalcones. Various Pyrazoline derivatives were prepared by reflux reaction of Chalcone with Phenyl Hydrazine Hydrate in ethanolic solution. The structures of the newly synthesized Pyrazoline derivatives have been characterized by spectral data. Keywords: Pyrazolines, chalcones, spectral analysis.
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V., Muralidharan, Asha Deepti C., and Raja S. "A REVIEW ON ANTI-INFLAMMATORY POTENTIAL OF SUBSTITUTED PYRAZOLINE DERIVATIVES SYNTHESISED FROM CHALCONES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 2 (2018): 9. http://dx.doi.org/10.22159/ijpps.2018v10i2.23772.

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The pyrazoline ring is a ubiquitous structural feature of many natural and synthetic compounds with potent anti-inflammatory activity. The creation of novel pyrazoline derivatives and examination of their chemical and biological behaviour have gained additional focus in the current decade. Pyrazolines and its fused heterocyclic derivatives tested with anti-inflammatory activity constitute a significant class of compounds for novel drug evolution. Pyrazoline nucleus when linked with different substituents like alkyl, aromatic, heterocyclic rings and many other groups at different positions on t
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Abeed, Ahmed A. O., Talaat I. El-Emary, and Mohamed S. K. Youssef. "A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles." Current Organic Synthesis 16, no. 3 (2019): 405–12. http://dx.doi.org/10.2174/1570179416666181210160908.

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<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocy
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Gineinah, Magdy. "6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS." Scientia Pharmaceutica 69, no. 1 (2001): 53–61. http://dx.doi.org/10.3797/scipharm.aut-01-06.

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Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazoline were prepared by cyclization with phenylhydrazine of the appropriate 1,3-diphenyl-2-propen-1-one derivatives obtained from arninoacetophenone and differently substituted aldehydes. However, the newly synthesized 2-aminobenzothiazole derivatives of pyrazoline were subjected to cyclization with ethyl brornopyruvate to afford the formation of 6-
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Shaikh, Sabiya K.* Md. Rayees Ahemad. "Review: Anticancer Activity Of Pyrazole." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 334–40. https://doi.org/10.5281/zenodo.10809286.

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The study of pharmaceutical chemistry is devoted to the search for and development of novel therapeutic medicines. While inorganic substances like antacids, mineral supplements, and radiopharmaceuticals continue to play a significant role in therapy, organic molecules with more focused pharmacological actions are gaining ground. The five and six-membered heterocyclic nitrogen-containing systems, which have demonstrated their effectiveness in fields like anti-bacterial, fungicidal, anti-inflammatory, anticonvulsant, diuretics, and anti-histaminic treatments, are among the most significant in on
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Sultan, Mohammed Ibrahim, Ahmed M. Abdula, Rana I. Faeq, and Mahdi F. Radi. "New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study." Al-Mustansiriyah Journal of Science 32, no. 3 (2021): 8. http://dx.doi.org/10.23851/mjs.v32i3.955.

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A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in
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Matsumura, Noboru, Akira Kunugihara, and Shigeo Yoneda. "Novel synthesis of pyrazole and pyrazoline derivatives." Journal of Heterocyclic Chemistry 22, no. 5 (1985): 1169–72. http://dx.doi.org/10.1002/jhet.5570220503.

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Mantzanidou, Martha, Eleni Pontiki, and Dimitra Hadjipavlou-Litina. "Pyrazoles and Pyrazolines as Anti-Inflammatory Agents." Molecules 26, no. 11 (2021): 3439. http://dx.doi.org/10.3390/molecules26113439.

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The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid. The compounds are obtained in good yields 68–99% and their structure was confirmed using IR, 1H-NMR, 13C-NMR and elemental analysis. The novel derivatives were
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Feng, Qi, Wenhui Huan, Jiali Wang, Jiadan Lu, Guowang Diao, and Yaqi Shan. "Crystal Structures and Optical Properties of Two Novel 1,3,5-Trisubstituted Pyrazoline Derivatives." Crystals 8, no. 12 (2018): 467. http://dx.doi.org/10.3390/cryst8120467.

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Two novel 1,3,5-trisubstituted pyrazoline derivatives—1-acetyl-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-pyrazoline (2a) and 1-(4-nitrophenyl)-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphtyl)-pyrazoline (2b)—were synthesized and their structures were determined by single crystal X-ray crystallography. Both of the two crystals exhibit twisted structures due to the large dihedral angles between the pyrazolinyl ring and the aromatic ring at the 5-position (88.09° for 2a and 71.26° for 2b). The optical–physical properties of the two compounds were investigated. The fluorescent emission of 2b arises
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Tok, Fatih, and Bedia Koçyiğit-Kaymakçıoğlu. "Design, Synthesis and Biological Screening of Novel 1,5-Diphenyl-3-(4-(trifluoromethyl)phenyl)-2-pyrazoline Derivatives." Acta Chimica Slovenica 67, no. 4 (2020): 1139–47. http://dx.doi.org/10.17344/acsi.2020.6028.

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1-Phenyl-5-substituted-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized from chalcone derivatives. The structures of compounds were characterized by IR, 1H NMR spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro antioxidant activity using DPPH and ABTS methods, anti-inflammatory activity using lipoxygenase inhibitory method and antidiabetic activity using the α-glucosidase inhibitory method. Especially, pyrazoline derivatives exhibited stronger anti-inflammatory activity than the reference drug indomethacin (IC50: 50.4
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Dissertations / Theses on the topic "Novel Pyrazoline Derivatives"

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ATZORI, ELENA MARIA. "Design, synthesis and antiviral evaluation of pyrazole and pyrazoline derivatives as novel inhibitors of flavivirus and pestivirus replication." Doctoral thesis, 2017. http://hdl.handle.net/11573/931038.

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The Flaviviridae family represents a large group of viral pathogens which are divided, according to the current taxonomy, in four genera: Flavivirus (type spe¬cies, yellow fever virus (YFV)), Hepacivirus (type species, hepatitis C virus (HCV)), Pestivirus (type species, bovine virus diar¬rhea (BVDV)) and Pegivirus (type species, hepatitis G virus (HGV)). Despite the majority of these viruses are responsible for a wide range of severe diseases in humans and animals, specific antiviral therapies are currently available only for the treatment of HCV infections. The global, social and economic imp
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Yu-TsungLiu and 呂侑聰. "Novel Pyrazole Derivatives for Treating Osteoporosis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ew9k4v.

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碩士<br>國立成功大學<br>生物化學暨分子生物學研究所<br>106<br>Osteoporosis is known as an age-related disease that result from an imbalance between the generation and decomposition of the bone matrix. It is caused by either the degeneration of osteoblasts leading to weaker bone forming activity or the promotion of osteoclasts increasing bone resorption activity. To treat osteoporosis, several drugs are available now. However, there are still some drawbacks of the drugs such as many side effects and high cost. According to the situation, we would like to research and synthesize new compounds to treat osteoporosis.
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Carreira, Ana Rita Futre. "Synthesis and evaluation of novel pyrazole derivatives for cytotoxic activity." Master's thesis, 2018. http://hdl.handle.net/10773/24248.

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The growing number of cancer patients worldwide has led the scientific community to strengthen research efforts in this field. The development of novel drug candidates for cancer treatment has been largely studied. Among these, pyrazoles derivatives are a promising class for their wide range of pharmacological activities, including antitumoral action. This work describes the preparation of (E)-3(5)-(2-hydroxyphenyl)-4-styryl-1H-pirazole derivatives, either by glycosylation reactions or by the formation of ruthenium trithiacyclononane complexes. The new compounds aim at having antitumoral acti
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Kuo, Ting-Hao, and 郭廷濠. "Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/02135079789878535306.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>103<br>As human beings live longer, age-related diseases such as osteoporosis will become more prevalent. Intolerant side effects and poor responses to current treatments are observed. Therefore, novel effective therapeutic agents are greatly needed. Here, pyrazole derivatives were designed and synthesized, and their osteoclastogenesis inhibitory effects both in vitro and in vivo were evaluated. The most promising compound 13 with a 2- (dimethylamino)ethyl group inhibited markedly in vitro osteoclastogenesis as well as the bone resorption activity of osteoclasts. Comp
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Book chapters on the topic "Novel Pyrazoline Derivatives"

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Lakshminarayanan, B., Vijayakumar B., P. Parthiban, and N. Kannappan. "Synthesis, Characterization, and Antioxidant Evaluation of Novel Ethoxylated Pyrazoline Derivatives: Promising Molecules for Drug Design in Pharmaceutical and Chemical Industries." In Advanced Concepts in Pharmaceutical Research Vol. 7. B P International, 2024. http://dx.doi.org/10.9734/bpi/acpr/v7/11562f.

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Nandurkar, Deweshri, Kishor Danao, Vijayshri Rokde, Ruchi Shivhare, and Ujwala Mahajan. "Pyrazole Scaffold: Strategies toward the Synthesis and Their Applications." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108764.

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Pyrazoles have a wide range of applications in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Their popularity has skyrocketed since the early 1990s. Basically, Pyrazole (C3H3N2H) is a simple doubly unsaturated five membered heterocyclic aromatic ring molecule comprising two nitrogen (N) atoms at positions 1- and 2- and three carbon (C) atoms. Pyrazole nucleus is synthesized with various strategies such as multicomponent approach, dipolar cycloadditions, cyclocondensation of hydrazine with carbonyl system, using heterocyclic system and
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Shanawad, S. S., Sureshappa K. Sajjan, Shridhar A H, and Vidyagayatri Marrakkur. "PHOTOPHYSICAL AND BIOLOGICAL STUDIES ON NEWLY SYNTHESIZED NOVEL ARYLSUBSTITUTED PYRAZOLONE ANALOGUE." In Futuristic Trends in Chemical, Material Sciences & Nano Technology Volume 2 Book 12. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2023. http://dx.doi.org/10.58532/v2bs12p4ch1.

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In the present work, a new pyrazoles derivative namely ethyl 2-(2- (ethoxycarbonyl)hept-1-en-3-yl)6,7-dihydro3-hydroxy-2Hpyrazolo[4,3c]Pyridine5(4H)carboxylate (EP P) was synthesized and studied their biological and photophysical properties. The EEP structure was confirmed by 1H NMR, FT-IR and LCMS analyses. EPP show good inhibitor properties for S. aureus and C. albicans. The photophysical properties are estimated using density functional theory in gaussian-9w software. The ground state dipole moment, HOMO-LUMO and molecular electrostatic potential map are estimated using basis set B3LYP-311G
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Sudha, Bono Naga, N. Yella Subbaiah, and Manchala Mahalakshmi. "Synthesis, Characterization and Biological Activity of Some Novel Substituted 1,3,4-Pyrazole Derivatives." In Novel Aspects on Pharmaceutical Research Vol. 3. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/napr/v3/5301b.

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Khandebharad, A. U. "Exploring Sodium Gluconate as a Highly Effective Organocatalyst for Dihydropyrano[2,3-c]Pyrazole Derivatives Synthesis." In Novel Aspects on Chemistry and Biochemistry Vol. 5. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/nacb/v5/6883a.

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Conference papers on the topic "Novel Pyrazoline Derivatives"

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Muškinja, Jovana M., Jelena S. Katanić Stanković, and Zoran R. Ratković. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.351m.

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Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compound
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Jimoh, Yusuf, Idris Yunusa Abdullah, Asmau Nasir Hamza, et al. "In Silico Evaluation of Novel 2-Pyrazoline Carboxamide Derivatives as Potential Protease Inhibitors Against Plasmodium Parasites." In ECSOC 2024. MDPI, 2024. https://doi.org/10.3390/ecsoc-28-20224.

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Priyanka, S., S. Sivapriya, D. Sivakumar, M. Gopalakrishnan, M. Seenivasan, and H. Manikandan. "Synthesis and DFT calculation of novel pyrazole derivatives." In INTERNATIONAL CONFERENCE ON RECENT TRENDS IN APPLIED MATHEMATICAL SCIENCES (ICRTAMS-2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0063016.

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Ali, Tarik, Somaia Abdel-Karim, Kamilia El-Mahdy, and Salah Abdel-Aziz. "Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00374.

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Adel, Mariam H., and Hiba H. Ibraheem. "Novel pyrazole derivatives from N-substituted pyridinyl chalcones as anticancer agents: Synthesis and biological evaluation studies." In 4TH INTERNATIONAL CONFERENCE ON INNOVATION IN IOT, ROBOTICS AND AUTOMATION (IIRA 4.0). AIP Publishing, 2025. https://doi.org/10.1063/5.0254372.

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Patil, Vipul M., and Harinath N. More. "Enlarging the NSAIDs Family: Molecular Docking of Designed Pyrazole and Oxadiazole Derivatives as Novel Anti-Inflammatory Agents." In IECBM 2022. MDPI, 2022. http://dx.doi.org/10.3390/iecbm2022-13390.

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Abubaker, Mariam, Che Wan Zanariah Che Wan Ngah, Musa Ahmad, and Bambang Kuswandi. "Colorimetric determination of Al(III) based on the aggregation of gold nanoparticles functionalized with novel 4-benzoyl pyrazolone derivative." In RECENT ADVANCEMENT ON APPLIED PHYSICS, INDUSTRIAL CHEMISTRY AND CHEMICAL TECHNOLOGY: Proceedings of the International Conference on Recent Advancements in Science and Technology 2017 (ICoRAST2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5041233.

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