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Journal articles on the topic 'Novel Pyrazoline Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Dwivedi, Pratibha, and Dr Alka Pradhan. "Synthesis and Characterization of Various Pyrazolines From Chalcones." International Journal for Research in Applied Science and Engineering Technology 10, no. 5 (2022): 2108–10. http://dx.doi.org/10.22214/ijraset.2022.42656.

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Abstract: Some novel series of pyrazoline derivatives were synthesized from Chalcones. Various Pyrazoline derivatives were prepared by reflux reaction of Chalcone with Phenyl Hydrazine Hydrate in ethanolic solution. The structures of the newly synthesized Pyrazoline derivatives have been characterized by spectral data. Keywords: Pyrazolines, chalcones, spectral analysis.

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2

V., Muralidharan, Asha Deepti C., and Raja S. "A REVIEW ON ANTI-INFLAMMATORY POTENTIAL OF SUBSTITUTED PYRAZOLINE DERIVATIVES SYNTHESISED FROM CHALCONES." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 2 (2018): 9. http://dx.doi.org/10.22159/ijpps.2018v10i2.23772.

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The pyrazoline ring is a ubiquitous structural feature of many natural and synthetic compounds with potent anti-inflammatory activity. The creation of novel pyrazoline derivatives and examination of their chemical and biological behaviour have gained additional focus in the current decade. Pyrazolines and its fused heterocyclic derivatives tested with anti-inflammatory activity constitute a significant class of compounds for novel drug evolution. Pyrazoline nucleus when linked with different substituents like alkyl, aromatic, heterocyclic rings and many other groups at different positions on t

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3

Abeed, Ahmed A. O., Talaat I. El-Emary, and Mohamed S. K. Youssef. "A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles." Current Organic Synthesis 16, no. 3 (2019): 405–12. http://dx.doi.org/10.2174/1570179416666181210160908.

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<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocy

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4

Gineinah, Magdy. "6-, 7- AND 8-(5-ARY L-1-PHENYL-2-PYRAZOLIN-3-LY)IMIDAZO- AND PYRIMIDO[2,1-b]BENZOTHIAZOLES AS NOVEL ANTICONVULSANT AGENTS." Scientia Pharmaceutica 69, no. 1 (2001): 53–61. http://dx.doi.org/10.3797/scipharm.aut-01-06.

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Some new derivatives of 2-amino-5- and 6-(5-aryl-1-phenyl-2-pyrazolin-3-yl)benzothiazole were synthesized from the corresponding aminophenyl compounds by reaction with KSCN/Br2 to build up the benzothiazole ring. The aminophenyl derivatives of pyrazoline were prepared by cyclization with phenylhydrazine of the appropriate 1,3-diphenyl-2-propen-1-one derivatives obtained from arninoacetophenone and differently substituted aldehydes. However, the newly synthesized 2-aminobenzothiazole derivatives of pyrazoline were subjected to cyclization with ethyl brornopyruvate to afford the formation of 6-

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5

Shaikh, Sabiya K.* Md. Rayees Ahemad. "Review: Anticancer Activity Of Pyrazole." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 334–40. https://doi.org/10.5281/zenodo.10809286.

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The study of pharmaceutical chemistry is devoted to the search for and development of novel therapeutic medicines. While inorganic substances like antacids, mineral supplements, and radiopharmaceuticals continue to play a significant role in therapy, organic molecules with more focused pharmacological actions are gaining ground. The five and six-membered heterocyclic nitrogen-containing systems, which have demonstrated their effectiveness in fields like anti-bacterial, fungicidal, anti-inflammatory, anticonvulsant, diuretics, and anti-histaminic treatments, are among the most significant in on

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6

Sultan, Mohammed Ibrahim, Ahmed M. Abdula, Rana I. Faeq, and Mahdi F. Radi. "New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study." Al-Mustansiriyah Journal of Science 32, no. 3 (2021): 8. http://dx.doi.org/10.23851/mjs.v32i3.955.

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A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in

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7

Matsumura, Noboru, Akira Kunugihara, and Shigeo Yoneda. "Novel synthesis of pyrazole and pyrazoline derivatives." Journal of Heterocyclic Chemistry 22, no. 5 (1985): 1169–72. http://dx.doi.org/10.1002/jhet.5570220503.

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8

Mantzanidou, Martha, Eleni Pontiki, and Dimitra Hadjipavlou-Litina. "Pyrazoles and Pyrazolines as Anti-Inflammatory Agents." Molecules 26, no. 11 (2021): 3439. http://dx.doi.org/10.3390/molecules26113439.

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The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid. The compounds are obtained in good yields 68–99% and their structure was confirmed using IR, 1H-NMR, 13C-NMR and elemental analysis. The novel derivatives were

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9

Feng, Qi, Wenhui Huan, Jiali Wang, Jiadan Lu, Guowang Diao, and Yaqi Shan. "Crystal Structures and Optical Properties of Two Novel 1,3,5-Trisubstituted Pyrazoline Derivatives." Crystals 8, no. 12 (2018): 467. http://dx.doi.org/10.3390/cryst8120467.

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Two novel 1,3,5-trisubstituted pyrazoline derivatives—1-acetyl-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-pyrazoline (2a) and 1-(4-nitrophenyl)-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphtyl)-pyrazoline (2b)—were synthesized and their structures were determined by single crystal X-ray crystallography. Both of the two crystals exhibit twisted structures due to the large dihedral angles between the pyrazolinyl ring and the aromatic ring at the 5-position (88.09° for 2a and 71.26° for 2b). The optical–physical properties of the two compounds were investigated. The fluorescent emission of 2b arises

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10

Tok, Fatih, and Bedia Koçyiğit-Kaymakçıoğlu. "Design, Synthesis and Biological Screening of Novel 1,5-Diphenyl-3-(4-(trifluoromethyl)phenyl)-2-pyrazoline Derivatives." Acta Chimica Slovenica 67, no. 4 (2020): 1139–47. http://dx.doi.org/10.17344/acsi.2020.6028.

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1-Phenyl-5-substituted-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized from chalcone derivatives. The structures of compounds were characterized by IR, 1H NMR spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro antioxidant activity using DPPH and ABTS methods, anti-inflammatory activity using lipoxygenase inhibitory method and antidiabetic activity using the α-glucosidase inhibitory method. Especially, pyrazoline derivatives exhibited stronger anti-inflammatory activity than the reference drug indomethacin (IC50: 50.4

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11

Jumaah, Maadh, Melati Khairuddean, and Tutik Dwi Wahyuningsih. "Design, Synthesis, and Biological Evaluation of Novel Trifluoromethoxy Substituted Pyrazolines as Potential Tubulin Assembling Inhibitors." Materials Science Forum 1061 (May 26, 2022): 195–201. http://dx.doi.org/10.4028/p-e38749.

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Breast cancer is a major health problem with an increasing number of cases over the years. Few classes of anticancer agents have been developed but they established toxic effects on normal cells. Despite the availability of many effective drugs to treat different types of cancers, chemotherapeutic drugs are unable to distinguish between healthy and cancerous cells, resulting in the risk of side effects and drugs resistance. There is a continuous effort to find new agents to help bring this disease under control. In this study, novel fluorinated pyrazolines derivatives (2a-c) were designed and

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12

Namera, Dipti L., Khushal M. Kapadiya, Mitesh M. Chhatrola, and Umed C. Bhoya. "Microwave Assisted Synthesis of some Novel Sulphonamide Bearing Pyrazolone Core Structure." International Letters of Chemistry, Physics and Astronomy 30 (March 2014): 116–26. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.30.116.

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We have described some novel Sulphonamide bearing pyrazoline derivatives synthesized by conventional method as well as microwave assisted method of synthesis. The reaction of 4-(3-methyl-5-oxo-4,5-dihydro-1-H-pyrazol-1-yl)benzenesulphonamide with substituted benzaldehyde in the presence of Methanol as solvent and piperidine as catalyst, generated a series of substituted pyrazolone derivatives 4a-m. The structures of all synthesized compounds are well characterized by Mass spectroscopy, FT-IR, 1H NMR and elemental analysis. After obtaining experimental data regarding the yield and the time take

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13

Namera, Dipti L., Khushal M. Kapadiya, Mitesh M. Chhatrola, and Umed C. Bhoya. "Microwave Assisted Synthesis of some Novel Sulphonamide Bearing Pyrazolone Core Structure." International Letters of Chemistry, Physics and Astronomy 30 (March 12, 2014): 116–26. http://dx.doi.org/10.56431/p-d7mgbf.

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We have described some novel Sulphonamide bearing pyrazoline derivatives synthesized by conventional method as well as microwave assisted method of synthesis. The reaction of 4-(3-methyl-5-oxo-4,5-dihydro-1-H-pyrazol-1-yl)benzenesulphonamide with substituted benzaldehyde in the presence of Methanol as solvent and piperidine as catalyst, generated a series of substituted pyrazolone derivatives 4a-m. The structures of all synthesized compounds are well characterized by Mass spectroscopy, FT-IR, 1H NMR and elemental analysis. After obtaining experimental data regarding the yield and the time take

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14

Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione,para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 30–41. http://dx.doi.org/10.1155/2005/953107.

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1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation withp–amino acetophenone gives 1-[acetyl] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative. This derivative undergo condensation with 2,4- dichloro benzaldehyde gives 1- [3” - (sub. phenyl) - 2” - propene - 1” - one] - 1’ , 2’ - [dichloro] - dibenz sulphonamide derivative which on reaction with 99% hydrazine hydrate and glacial acetic acid gives 1-[acetyl]-3- [1’ , 2’ - (dichloro) - dibenz sulphonamide] -5 - [2” , 4” - dichloro phenyl] - 2 - py

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15

Banday, Abid H., Shameem A. Shameem, Javid A. Banday та Bashir A. Ganaie. "Synthesis, 17α-hydroxylase-C17,20-lyase Inhibitory and 5AR Reductase Activity of Novel Pregnenolone Derivatives". Anti-Cancer Agents in Medicinal Chemistry 18, № 13 (2019): 1919–26. http://dx.doi.org/10.2174/1871520618666180426100942.

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Background: The potential of steroids for development into lead pharmacological molecules lies in the regulation of a variety of biological processes by these molecules and also because of these being a fundamental class of signaling molecules. Steroid based scaffolds have been extensively used as active pharmaceutical agents for the treatment of various diseases including the deadly disease of cancer which despite the recent advances in the early diagnosis, prevention and therapy, remains a clinical challenge affecting millions of people world over and is one of the leading causes of death. I

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16

Abdollahi-Alibeik, Mohammad, Ali Moaddeli, and Kianoosh Masoomi. "BF3 bonded nano Fe3O4 (BF3/MNPs): an efficient magnetically recyclable catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives." RSC Advances 5, no. 91 (2015): 74932–39. http://dx.doi.org/10.1039/c5ra11343a.

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1,4-Dihydropyrano[2,3-c]pyrazole derivatives were efficiently synthesized in a simple one-pot three-component reaction of various aldehydes with malononitrile and a 2-pyrazoline-5-one in the presence of BF<sub>3</sub>/MNPs as a novel nanostructured, heterogeneous and reusable catalyst.

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17

Lamie, Phoebe F. "Synthesis and Antimicrobial Activity of some Novel Isoindoline-1,3-Dione Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 8, no. 2 (2008): 1660–66. http://dx.doi.org/10.24297/jac.v8i2.5570.

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New phthalimido derivatives incorporated with chalcone, pyrazole, pyrazoline, and pyrimidine moieties were synthesized and evaluated for their antimicrobial activities against bacterial and fungal strains. 2-{4-[1-Acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl} isoindoline-1,3-dione (7) showed broad spectrum antibacterial activity against both G+ and G- bacteria. While, (E)-2-{4-[3-(4-chlorophenyl)acryloyl]phenyl}isoindoline-1,3-dione (4b) showed promising antifungal activity.

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18

Farag, Awatef A., Mohamed F. El Shehry, Samir Y. Abbas, et al. "Synthesis of pyrazoles containing benzofuran and trifluoromethyl moieties as possible anti-inflammatory and analgesic agents." Zeitschrift für Naturforschung B 70, no. 7 (2015): 519–26. http://dx.doi.org/10.1515/znb-2015-0009.

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AbstractSearching for new anti-inflammatory and analgesic agents, we have prepared a series of novel pyrazoles containing benzofuran and trifluoromethyl moieties. The pyrazole derivatives have been synthesized via two routes starting from 5-(3-(trifluoromethyl)phenyl azo) salicylaldehyde. The first route involved the synthesis of 2-acetylbenzofuran and then treatment with aldehydes to afford the corresponding chalcones. The cyclization of the latter chalcones with hydrazine hydrate led to the formation of new pyrazoline derivatives. The second route involved the synthesis of benzofuran-2-carbo

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19

Swathi, Perla, and RAJA SUNDARARAJAN. "Cytotoxic Activity and Molecular Docking Studies of Novel 1,3,5-Substituted 2-Pyrazoline Derivatives." Asian Journal of Chemistry 35, no. 11 (2023): 2829–36. http://dx.doi.org/10.14233/ajchem.2023.30554.

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A series of novel 1,3,5-substituted 2-pyrazoline derivatives (IIIa-j) comprising benzo[7]annulene moiety and aromatic substitutions were synthesized via the reaction of (E)-3-(9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulen-8-yl)-1-(substituted phenyl)prop-2- n-1-one with phenylhydrazine. Using spectroscopic methods, the structures of the synthesized derivatives were confirmed. The newly synthesized pyrazoline derivatives were put to the test in vitro on two cancer cell lines (HT-29 and MCF-7). After 72 h of incubation, the results showed that compounds IIId and IIIb altered the morpholog

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20

Moura, Nuno M. M., Maria A. F. Faustino, Maria G. P. M. S. Neves, et al. "Novel pyrazoline and pyrazole porphyrin derivatives: synthesis and photophysical properties." Tetrahedron 68, no. 39 (2012): 8181–93. http://dx.doi.org/10.1016/j.tet.2012.07.072.

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21

M., E. ELBA, I. DARWISH A., and M. MAMADA N. "Synthesis of Novel Pyrazoline Derivatives. I. Reaction of erythro-2,3-Dibromoketones with Semi- and Thiosemicarbazides." Journal of Indian Chemical Society Vol. 74, Mar 1997 (1997): 202–5. https://doi.org/10.5281/zenodo.5877769.

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Department of Physics and Chemistry, Faculty of Education, Alexandria University, Alex. Egypt <em>Manuscript received 23 June 1994, revised 1 August 1995, accepted 9 October 1995</em> The reaction of a series of <em>ertyhro</em>-1,3-dibromo-1,3-diaryl-1-porpanones with four molar equivalents of semicarbazide hydrochloride or thiosemicarbazide In dioxane or ethanol leads to. the formation of trisubstituted pyrazolines and their 4-bromo derivatives. The pyrazolines have been Identified' by chemical and spectral data. A reaction mechanism is also proposed.

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22

El-Ossaily, Y. A. B., R. M. Zaki, and S. A. Metwally. "Investigation and Synthesis of Some Novel Spiro Heterocycles Related to Indoline Moiety." Journal of Scientific Research 6, no. 2 (2014): 293–307. http://dx.doi.org/10.3329/jsr.v6i2.17590.

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Reactions of indole-2,3-dione 1 with 2-mercaptobenzimidazole, o-phenylenediamine, 2-aminophenol, 2-aminobenzothiazole, 2-aminobenzimidazole and 3-methyl-1-phenyl-2-pyrazolin-5-one were carried out to give compounds spiroindolethiazetobenzimidazole 2, spirobenzimidazole(oxazole)indoline 3a,b, benzothiazol(imidazol) iminoindolinone 4a,b and methyloxoindolylidenepyrazolone 5 respectively. Compound 5 was reacted with 2-aminophenol as well as o-phenylenediamine to give new spirooxazepine and diazepine derivatives 6a,b respectively. Reaction of 5 with nitrogen nucleophiles as well as carbon nucleoph

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23

Kheder, Nabila A., Yahia N. Mabkhot, Fawzia R. Zahian, and Sara S. Mohamed. "Regioselective Synthesis of Some Pyrazole Scaffolds Attached to Benzothiazole and Benzimidazole Moieties." Journal of Chemistry 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/581721.

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Condensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2-carbaldehyde afforded the corresponding acrylonitrile derivatives3or4, respectively. The 1,3-dipolar cycloaddition reaction of the acrylonitrile3or4with nitrile-imine6gave novel pyrazole derivatives pendant to benzothiazole and benzimidazole. The pyrazoline derivative7was converted into the corresponding pyrazole derivative11via thermal elimination of hydrogen cyanide upon heating in sodium ethoxide solution. The structures of the synthesized products were confirmed by IR

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24

Revanasiddappa, B. C., M. Vijay Kumar, and Hemanth Kumar. "Synthesis and Antioxidant activity of novel Pyrazoline derivatives." Hygeia J. D.Med.10 (1) August 2018 - January 2019 10, no. 1 (2018): 43–49. http://dx.doi.org/10.15254/h.j.d.med.10.2018.177.

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Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted

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25

Kumar, C. H. Praveen, S. Katagi Manjunatha, and B. P. Nandeshwarappa. "Synthesis of novel pyrazolic analogues of chalcones as potential antibacterial and antifungal agents." Current Chemistry Letters 12, no. 3 (2023): 613–22. http://dx.doi.org/10.5267/j.ccl.2023.2.001.

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The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic acti

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26

Edrees, Mastoura, Sraa Melha, Amirah Saad, Nabila Kheder, Sobhi Gomha, and Zeinab Muhammad. "Eco-Friendly Synthesis, Characterization and Biological Evaluation of Some Novel Pyrazolines Containing Thiazole Moiety as Potential Anticancer and Antimicrobial Agents." Molecules 23, no. 11 (2018): 2970. http://dx.doi.org/10.3390/molecules23112970.

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The one-pot synthesis of a series of pyrazoline derivatives containing the bioactive thiazole ring has been performed through a 1,3-dipolar cycloaddition reaction of N-thiocarbamoylpyrazoline and different hydrazonoyl halides or α-haloketones in the presence of DABCO (1,4-diazabicyclo[2.2.2] octane) as an eco-friendly catalyst using the solvent-drop grinding method. The structure of the synthesized compounds was elucidated using elemental and spectroscopic analyses (IR, NMR, and Mass). The activity of these compounds against human hepatocellular carcinoma cell line (HepG2) was tested and the r

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27

Behbehani, Haider, Hamada Mohamed Ibrahim, and Kamal M. Dawood. "Ultrasound-assisted regio- and stereoselective synthesis of bis-[1′,4′-diaryl-1-oxo-spiro-benzosuberane-2,5′-pyrazoline] derivatives via 1,3-dipolar cycloaddition." RSC Advances 5, no. 33 (2015): 25642–49. http://dx.doi.org/10.1039/c5ra02972d.

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Taj, Tasneem, Ravindra R. Kamble, Atukuri Dorababu, and Gangadhar Y. Meti. "Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann Reaction: Investigation of Antimicrobial Activities." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/909706.

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In the present investigation, 1,2,4-triazole appended to pyrazoline and pyrazole rings (4a–g) using N-arylsydnone as synthon was prepared. The title compounds were subjected to Osiris property explorer for the oral bioavailability to analyze their drug likeness and drug score. Further, the compounds were subjected to the antimicrobial activity and analyzed the IC 50 and MIC values.

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Mahdi, Inas S., Ahmed Mutanabbi Abdula, Abdulkadir M. Noori Jassim, and Younis Baqi. "Design, Synthesis, Antimicrobial Properties, and Molecular Docking of Novel Furan-Derived Chalcones and Their 3,5-diaryl-∆2-pyrazoline Derivatives." Antibiotics 13, no. 1 (2023): 21. http://dx.doi.org/10.3390/antibiotics13010021.

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The present work focuses on the synthesis and preliminary structure activity relationships (SARs) of furan-derived chalcones and their corresponding ∆2-pyrazoline derivatives as antimicrobial agents. Eight novel chalcone derivatives and eight ∆2-pyrazoline compounds were synthesized in moderate to good isolated yields. The target compounds were evaluated as antimicrobial agents against two Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis), two Gram-negative (Escherichia coli and Klebsiella pneumoniae), and fungi (Candida albicans) species. Based on the SARs, chalcones 2a and

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30

Raguraman, A., and N. Santhi. "Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity." International Letters of Chemistry, Physics and Astronomy 39 (October 2014): 219–33. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.39.219.

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A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized deriva

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Raguraman, A., and N. Santhi. "Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity." International Letters of Chemistry, Physics and Astronomy 39 (October 2, 2014): 219–33. http://dx.doi.org/10.56431/p-10v8y4.

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A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized deriva

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32

Unsal-Tan, Oya, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, Ayla Balkan, and Keriman Ozadali-Sari. "Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease." MedChemComm 10, no. 6 (2019): 1018–26. http://dx.doi.org/10.1039/c9md00030e.

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33

Burmudžija, Adrijana, Zoran Ratković, Jovana Muškinja, et al. "Ferrocenyl based pyrazoline derivatives with vanillic core: synthesis and investigation of their biological properties." RSC Advances 6, no. 94 (2016): 91420–30. http://dx.doi.org/10.1039/c6ra18977f.

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Bhandari, Shradha, Avinash C. Tripathi, and Shailendra K. Saraf. "Novel 2-pyrazoline derivatives as potential anticonvulsant agents." Medicinal Chemistry Research 22, no. 11 (2013): 5290–96. http://dx.doi.org/10.1007/s00044-013-0530-7.

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35

Padhy, Gopal, Jagadeesh Panda, and Ajaya Behera. "Synthesis and characterization of novel benzimidazole embedded 1,3,5-trisubstituted pyrazolines as antimicrobial agents." Journal of the Serbian Chemical Society 82, no. 9 (2017): 985–93. http://dx.doi.org/10.2298/jsc160604089p.

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Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and spectral studies (IR, 1D/2D NMR techniques and mass spectrometry). The synthesized compounds were screened for their antimicrobial activity against selected Gram-positive and Gram-negative bacteria, and fungi strain. The compounds with halo substituted phenyl group at C5 of the 1-phenyl pyrazoline ring (15, 16 and 17) showed significant antibacterial activity.

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36

Agare, Sandip U., Mahesh P. More, Sanjay P. Tajane, and Tanuja V. Kadre. "Synthesis, Characterization and Biological Activity of Novel Heterocyclic Compounds Containing Acylated Pyrazoline." Oriental Journal Of Chemistry 40, no. 2 (2024): 499–505. http://dx.doi.org/10.13005/ojc/400223.

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A set of novel acylated pyrazoline compounds 3(a-i) was prepared and structural elucidation was confirmed by using spectroscopic techniques such as 1H-NMR, FT-IR, and mass spectroscopy. Progress of the reaction was monitored by TLC. The synthesized set of acylated pyrazoline compounds 3(a-i) was evaluated for antimicrobial screening which reveals that these compounds have interesting properties. The discs diffusion method was utilized to perform in-vitro antimicrobial activity of pyrazoline derivatives 3(a-i) against Escherichia coli (MCC-2412), Staphylococcus aureus (MCC-2408), B. subtilis (M

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37

Kadam, Mayur, Nitin L. Jadhao, and Jayant M. Gajbhiye. "Synthesis of pyrazole and 1,3,4-oxadiazole derivatives of pharmaceutical potential." Prospects in Pharmaceutical Sciences 22, no. 3 (2024): 127–35. http://dx.doi.org/10.56782/pps.235.

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Heterocyclic compounds are important molecules that serve as scaffolds or linkers for the core structure of numerous drug substances. In particular, pyrazole and 1,3,4-oxadiazole are compounds of great interest due to their comprehensive biological activities and interesting structural features. Here, we described an efficient and economical synthetic route leading to N-phenyl substituted pyrazole and 1,3,4-oxadiazole derivatives. Retrosynthetic disconnective analysis showed that the N-phenyl substituted pyrazole can be obtained from chalcone, accessible from the respective aldehyde, and aceto

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38

Revanasiddappa, BC, MS Jisha, M. Vijay Kumar, and Hemanth Kumar. "Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives." Dhaka University Journal of Pharmaceutical Sciences 17, no. 2 (2018): 221–26. http://dx.doi.org/10.3329/dujps.v17i2.39179.

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A new series of chalcones (2a-j) were prepared by reacting substituted aldehydes and substituted ketones in alcohol medium in presence of NaOH. The chalcones underwent selective cyclization with guanicol hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted pyrazolines (3a-j). The new compounds were characterized on the basis of 1H-NMR, IR and mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. Some of the tested compounds 3a and 3e showed good activity against bacterial strai

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39

Revanasiddappa, B. C., M. Vijay Kumar, Prashanth Nayak, Ajmal Roshan Ali, and M. S. Jisha. "Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives." Research Journal of Pharmacy and Technology 10, no. 5 (2017): 1481. http://dx.doi.org/10.5958/0974-360x.2017.00261.x.

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Ali, Mohamed Ashraf, Mohammad Shahar Yar, Mahesh Kumar, and Ganesan Suresh Pandian. "Synthesis and antitubercular activity of substituted novel pyrazoline derivatives." Natural Product Research 21, no. 7 (2007): 575–79. http://dx.doi.org/10.1080/14786410701369367.

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41

SHAFI, S. SYED, P. SUBASHINI, S. GAJALAKSHMI, and V. VIJAYA KUMAR. "An Efficient Suitable Synthesis for Pyrazole, Pyrimidine Derivatives and Biological Evaluation." Asian Journal of Chemistry 33, no. 4 (2021): 734–40. http://dx.doi.org/10.14233/ajchem.2021.23095.

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Novel quinazoline derivatives were synthesized by reacting isatoic anhydride and 4-amino acetanilide to synthesize N-(4-(2,4-dioxo-1,2- dihydroquinazolin-3(4H)-yl)phenyl)acetamide which in turn reacted with substituted aromatic aldehydes to synthesize novel chalcones. The chalcones were allowed to react with hydrazine hydrochloride and guanidine to form pyrazoline and pyrimidine derivatives, respectively. The newly synthesized compounds were characterized by IR, NMR (1H, 13C), mass and elemental analysis. All the newly synthesized derivatives were screened for in vitro antimicrobial and antiox

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42

Aggarwal, Shilpy, Deepika Paliwal, Dhirender Kaushik, Girish Kumar Gupta, and Ajay Kumar. "Synthesis, Antimalarial Evaluation and SAR Study of Some 1,3,5-Trisubstituted Pyrazoline Derivatives." Letters in Organic Chemistry 16, no. 10 (2019): 807–17. http://dx.doi.org/10.2174/1570178616666190212145754.

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The synthesis of a novel series of 1,3,5-trisubstitiuted pyrazoline was achieved by refluxing chalcone derivative with different heteroaryl hydrazines. The newly synthesized compounds were characterized by 1H NMR, 13CNMR, mass spectral and elemental analysis data. The synthetic series of novel pyrazoline hybrids was screened for in vitro schizont maturation assay against chloroquine sensitive 3D7 strain of Plasmodium falciparum. Most of the compounds showed promising in vitro antimalarial activity against CQ sensitive strain. The preliminary structure-activity relationship study showed that qu

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43

Lokesh, Bontha Venkata Subrahmanya, Y. Rajendra Prasad, and Afzal Basha Shaik. "Synthesis, Biological Evaluation and Molecular Docking Studies of New Pyrazolines as an Antitubercular and Cytotoxic Agents." Infectious Disorders - Drug Targets 19, no. 3 (2019): 310–21. http://dx.doi.org/10.2174/1871526519666181217120626.

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Background: Many synthetic procedures were reported till date to prepare pyrazoline derivatives. Some have published pyrazolines from different chalcone derivatives in the literature. Objective: A series of new pyrazolines containing novel 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M. tuberculosis H37Rv strain and in vitro anticancer activity against DU-145 prostate cancer cell lines and all compounds were also screened for molecular docking studies against

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Patel, Pineshkumar N., and Denish C. Karia. "Synthesis and Antimicrobial Activity of Novel Series of Diversely Substituted Acetyl Pyrazoline Bearing Biphenyl Carbonitrile Motif." International Letters of Chemistry, Physics and Astronomy 69 (August 2016): 42–48. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.69.42.

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Novel series of diversely substituted acetyl pyrazoline having biphenyl carbonitrile motif have been synthesized. The reaction of 2-cyno-4’-bromomethyl biphenyl with1-(4-hydroxy-phenyl)-ethanone resulted in acetophenone derivative of biphenyl-2-carbonitrile. This acetophenone derivative was condensed with substituted aromatic aldehyde in mixed solvent resulted in various substituted chalcones. These chalcones were further cyclized using hydrazine hydrate in presence of glacial acetic acid to produce titled compound derivatives. The chemical structures of synthesized compounds were elucidated b

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45

Patel, Pineshkumar N., and Denish C. Karia. "Synthesis and Antimicrobial Activity of Novel Series of Diversely Substituted Acetyl Pyrazoline Bearing Biphenyl Carbonitrile Motif." International Letters of Chemistry, Physics and Astronomy 69 (August 12, 2016): 42–48. http://dx.doi.org/10.56431/p-al2z39.

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Novel series of diversely substituted acetyl pyrazoline having biphenyl carbonitrile motif have been synthesized. The reaction of 2-cyno-4’-bromomethyl biphenyl with1-(4-hydroxy-phenyl)-ethanone resulted in acetophenone derivative of biphenyl-2-carbonitrile. This acetophenone derivative was condensed with substituted aromatic aldehyde in mixed solvent resulted in various substituted chalcones. These chalcones were further cyclized using hydrazine hydrate in presence of glacial acetic acid to produce titled compound derivatives. The chemical structures of synthesized compounds were elucidated b

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46

Lakshminarayanan B, Kannappan N, Subburaju T, and Kalaichelvan V K. "Synthesis of some novel 3- (4-ethoxyphenyl) -5- (4-substituted) -4,5-dihydro-1H-pyrazole derivatives as potent antioxidant agents." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1571–77. http://dx.doi.org/10.26452/ijrps.v11i2.2035.

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Pyrazolines are the most useful heterocyclic moiety in Pharmaceutical and Chemical fields and as the most potential molecules for the design of new chemical entities. Nitrogen-containing heterocyclic compounds, pyrazolines and their derivatives showed a variety of pharmacological activities, including antioxidant properties. In the present study, eleven novel ethoxylated pyrazoline derivatives were synthesized by condensing chalcones with electron releasingethoxy group at one end and different electron-donating, electron-withdrawing groups in another end with hydrazine hydrate andalcohol. The

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47

Abdelmohsen, Shawkat A., and Talaat I. El Emary. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 7 (2014): 2901–15. http://dx.doi.org/10.24297/jac.v10i7.6802.

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The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydra

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48

Yar, Shahar, Ahmad Siddiqui, and Ashraf Ali. "Synthesis and antimycobacterial activity of novel heterocycles." Journal of the Serbian Chemical Society 72, no. 1 (2007): 5–11. http://dx.doi.org/10.2298/jsc0701005y.

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In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI-CXI). These chalcones were further reacted with hydrazine hydrate in ethanol which led to the formation of pyrazoline derivatives (HI-HXI). The newly synthesized heterocyles were characterized on the basis of their chemical properties and spectroscopic data. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv. .

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49

Jadhav, Sagar A., P. J. Shirote, Kiran M. Kulkarni, and Vipul M. Patil. "Synthesis, Spectral Analysis and Anticancer Evaluation of Novel Pyrazoline Derivatives." American Journal of PharmTech Research 8, no. 1 (2018): 303–15. http://dx.doi.org/10.46624/ajptr.2018.v8.i1.021.

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Kini, Suvarna, and AM Gandhi. "Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents." Indian Journal of Pharmaceutical Sciences 70, no. 1 (2008): 105. http://dx.doi.org/10.4103/0250-474x.40344.

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