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Dissertations / Theses on the topic 'Novel targeted therapies'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Bolin, Sara. "Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies." Doctoral thesis, Uppsala universitet, Neuroonkologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300907.

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Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. To improve progression-free survival and quality of life for these children, finding new therapeutic targets in medulloblastoma is imperative. Medulloblastoma is divided in to four molecular subgroups (WNT, SHH, Group 3 and Group 4) based on key developmental pathways essential for the initiation and maintenance of tumor development. The MYC family of prot

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2

Dawson, Jesse. "Prevention of stroke risk stratification and targeted and novel therapies /." Thesis, Connect to e-thesis, 2009. http://theses.gla.ac.uk/851/.

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Thesis (MD.) - University of Glasgow, 2009.<br>MD. thesis submitted to Division of Cardiovascular and Medical Sciences, University of Glasgow, 2009. Includes bibliographical references. Print version also available.

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3

Tavallai, Mehrad. "INTRODUCING NOVEL COMBINATORIAL TARGETED THERAPIES IN MULTIPLE TYPES OF CANCER." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4088.

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The cancers of liver, colon and breast are amongst the top five most prevalent and most fatal worldwide. As the Raf/MEK/ERK pathway is frequently deregulated in hepatocellular carcinoma (HCC), sorafenib, a Raf kinase inhibitor, became the first systemic therapy approved for the treatment of patients with HCC. However, sorafenib only produced modest effects with low response rates in the clinic. Similarly, regorafenib, which was approved for the treatment of metastatic colorectal cancer (CRC), has had a poor response rate in the clinic. Since phosphodiesterase type 5 has been reported to be ove

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4

Kouadio, Ange S. "Exploring the therapeutic potential of novel molecular targeted therapies in treating human ovarian cancer." Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1650501211&sid=2&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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5

Ferrari, Mathieu. "Characterisation of scFv A7 reactivity and development of a novel bispecific antibody for targeted therapies in Rheumatoid Arthritis." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8975.

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Despite the success of current biological agents, achievement of broader efficacy and improved safety profile remains an unmet need in rheumatoid arthritis therapy. Neovasculogenesis plays a vital role in the progression and perpetuation of rheumatoid arthritis and significant evidence has demonstrated molecular heterogeneity within the endothelium (MVE) of different tissues. The heterogeneity of the synovial MVE can be exploited for the development of organ-specific therapeutic and diagnostic reagents. A novel recombinant antibody fragment, scFv A7, with specificity for human arthritic synovi

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6

Hernández, Prat Anna 1984. "Antitumor effects of novel targeted therapies (TAK-228 and TAK-117) with high selectivity againts PI3K/AKT/mTOR pathway in bladder cancer : Defining molecular markers." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664507.

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El càncer de bufeta avançat s'associa amb un mal pronòstic i amb opcions limitades de tractament. Tot i l’èxit recent amb l'ús d'inhibidors immunitaris, no tots els pacients responen a la teràpia i encara hi ha la necessitat d'opcions alternatives. La ruta de PI3K/AKT/mTOR està sobreactivada sovint en aquesta patologia i pot ser un objectiu terapèutic potencial per a la intervenció terapèutica. Es va estudiar l'eficàcia antitumoral del TAK-228, un inhibidor oral de mTORC1 / 2 en models preclínics de càncer de bufeta amb alteracions en la transducció de senyals d'aquesta via. Es va demostrar un

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7

Gifu, Elena Patricia. "Emergence of cancer stem cells in the early stages of hepatic carcinogenesis and development of innovative models of hepatocellular carcinoma." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1319/document.

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Le carcinome hépatocellulaire est un grand problème de santé publique et la troisième de mortalité lié au cancer dans le monde. Il a été démontré qu'au sein des tumeurs se trouve un petite population des cellules cancéreuses avec des propriétés de cellules souches cancéreuses. Elles sont responsables de l'initiation des tumeurs ainsi que de la récidive post-traitement et résistance aux thérapies. Peu de choses sont connues par rapport à la biologie de ces cellules mais l'identification des facteurs favorisant leur existence pourrait conduire vers des nouvelles pistes thérapeutiques.Nous avons

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8

Han, Yanyan. "Functional characterization of FMNL1 as potential target for novel anti-tumor therapies." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-112968.

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9

Gracia-Maldonado, Gabriel. "Exploiting the MLL-rearranged leukemia gene signature to identify molecular targets for novel therapies." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573570752309466.

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10

Sallaberry, Pinto Júlia. "Novel markers and targets of collective tumor cell invasion before and after anti-angiogenic therapies." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/666666.

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Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. Determining how tumor cells initiate and sustain local invasive behavior might help to improve patient diagnosis and lead to the development of new intervention modalities. Therefore, the aim of this thesis is to elucidate which molecular mechanisms are involved in PanNETs invasion before and after anti-angiogenic therapies. Results from our group have demonstrated an irr

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11

Tarrado, Castellarnau Miriam. "Targeting metabolic reprogramming associated to cancer cells: search of novel targets and combined therapies in cancer treatment." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/385425.

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Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer are two of the most common cancers worldwide. In early stages of the disease, surgery is the common choice while chemotherapy is the main treatment for advanced stage cancer. However, the currently available chemotherapeutic treatments exhibit modest efficacy due to their side effects and drug resistance. Therefore, the search for combined chemotherapies with low systemic to

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12

Seckl, Michael Julian. "Neuropeptide receptors and cell signals as targets in the development of novel therapies for small cell lung cancer." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281770.

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13

Jolly, Simmi. "Pharmacological characterisation of selective Y4 and dual Y2/Y4 receptor agonists : novel targets for putative anti-obesity therapies." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/pharmacological-characterisation-of-selective-y4-and-dual-y2y4-receptor-agonists(b9e837b1-e9ca-4bc6-9b85-5b93a7357819).html.

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The GIPIO (Gastrointestinal Peptides in Obesity) collaboration was set up with EU (FP7) funding in 2008, with the aim to develop a series of peptide analogues for the treatment of obesity. Based on the dual Y2/Y4 agonist, Obinepitide ([Q34]hPP), and the Y4 agonist, TM30339 (hPP2-36), novel peptides were developed and subsequently modified by either PEGylation or lipidation to improve their relatively short half-life and pharmacokinetic profile. This thesis presents a detailed study of the in vitro pharmacological data performed to aid the progression of the most promising peptide candidates. A

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14

Montes, Cobos Elena [Verfasser], Holger [Akademischer Betreuer] Reichardt, Lutz [Gutachter] Walter, and Fred [Gutachter] Lühder. "Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies / Elena Montes Cobos ; Gutachter: Lutz Walter, Fred Lühder ; Betreuer: Holger Reichardt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/111721947X/34.

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15

Buscone, Serena. "Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16001.

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Light and optical techniques have made a profound impact on modern medicine both in diagnostics and in therapy. Therapeutic action of light is based on photomechanical, photothermal, photochemical and photobiological interactions, depending on the wavelength, power density, exposure time and optical properties of tissue and cells. Last decade experienced a growing rise of commercial devices for management of hair growth, where all of them are based on low levels of light resulting into photobiological, non-thermal interaction of photons with cells, a process that recently has received an offic

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16

Morel, Daphné. "Identifying Synthetic Lethal and Selective Approaches to Target PBRM1-Deficiency in Clear Cell Renal Cell Carcinoma PBRM1 Deficiency in Cancer is Synthetic Lethal with DNA Repair Inhibitors Exploiting Epigenetic Vulnerabilities in Solid Tumors: Novel Therapeutic Opportunities in the Treatment of SWI/SNF-Defective Cancers Combining Epigenetic Drugs with other Therapies for Solid Tumours — Past Lessons and Future Promise Targeting Chromatin Defects in Selected Solid Tumors Based on Oncogene Addiction, Synthetic Lethality and Epigenetic Antagonism." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL017.

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L’inactivation de polybromo-1 (PBRM1) est un évènement fréquent dans de nombreux cancers. En particulier, les carcinomes rénaux à cellules claires présentent une déficience en PBRM1 dans 40 à 50% des cas. A ce jour, il n’existe pas d’approche de médecine précision connue capable de cibler spécifiquement les cellules tumorales déficientes en PBRM1.Pour identifier des cibles de létalité synthétique associées à la perte de PBRM1, nous avons (i) réalisé un criblage pharmacologique à haut débit évaluant la sensibilité à 167 molécules dans un modèle cellulaire isogénique pour PBRM1, et (ii) étudié l

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17

Chan, Stefanie. "Characterizing triple negative breast cancer subpopulations for developing novel targeted therapies." Thesis, 2021. https://hdl.handle.net/2144/42227.

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Breast cancer is a multifaceted disease that affects 1 in every 8 women. Triple negative breast cancer (TNBC) accounts for ~15-20% of all diagnosed breast cancers and is characterized by the absence of ER, PR, and HER2 on the tumor cell surface. As most cancer therapies to date target these cell surface receptors, TNBC is the only subtype of breast cancer without a targeted therapy and thus prognosis for it remains poor. The heterogeneity of TNBC also makes finding a targeted therapy particularly difficult. This work focuses on different methods of targeting distinct subpopulations of TNBC in

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18

Lee, Helen Hyewon. "The molecular mechanisms of Alzheimer's disease and the promise of novel targeted therapies." Thesis, 2021. https://hdl.handle.net/2144/42334.

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Alzheimer’s disease is a common cause of dementia in the elderly population that is characterized by progressive neurodegeneration and decline in cognitive functions. Scientists do not yet fully understand the biological mechanisms that cause Alzheimer’s disease, making it increasingly difficult to develop targeted therapies that thoroughly address the responsible agents that lead to dementia and subsequently Alzheimer’s disease. There is currently no cure available to permanently stop the progression of or to reverse the damage due to Alzheimer’s disease. This study aims to provide an overvie

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19

Monteiro, Inês de Paula Costa. "Targeting HER family in HER2-positive metastatic breast cancer: potential biomarkers and novel targeted therapies." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/83769.

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20

Monteiro, Inês de Paula Costa. "Targeting HER family in HER2-positive metastatic breast cancer: potential biomarkers and novel targeted therapies." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/83769.

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21

Wang, Chang Ye Yale. "Novel Properties of SP cells in STS, and How They May Be Targeted to Develop Potential Therapies." Thesis, 2010. http://hdl.handle.net/1807/25503.

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Tumours contain heterogeneous cell populations. A population enriched in tumour-initiating potential has been identified in soft-tissue sarcoma (STS) by the isolation of "side population" (SP) cells. In this study, we compared the gene expression profiles of SP and non-SP cells in STS and identified Hedgehog (Hh) and Notch pathways as potential candidates for the targeting of SP cells. Upon verification of the activation of these pathways in SP cells, using primary tumor xenografts in NOD-SCID mice as our experimental model, we used the Hh blocker Triparanol and the Notch blocker DAPT to demon

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22

Bogalho, Ana Beatriz dos Santos. "Innovative therapeutic approaches to fight glioblastoma." Master's thesis, 2019. http://hdl.handle.net/10451/43342.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>O glioblastoma é um tumor agressivo do sistema nervoso central, com sobrevivência limitada e reduzidas opções de tratamento. A terapia standard consiste na ressecção cirúrgica seguida de radioterapia e quimioterapia com Temozolomida (TMZ). Doentes com glioblastoma têm uma diminuída esperança de vida e mesmo após tratamento, a recorrência do tumor é quase certa. Investigação tem sido feita para se descobrir novas terapias que possam melhorar o tratamento standard e o prognóstico.

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23

Heisig, Martin. "Development of novel Listeria monocytogenes strains as therapeutic agents for targeted tumor therapy." Doctoral thesis, 2010. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-48628.

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Despite marked progress in development and improvement of cancer therapies the rate of cancer related death remained stable over the last years. Especially in treating metastases alternative approaches supporting current therapies are required. Bacterial and viral vectors have been advanced from crude tools into highly sophisticated therapeutic agents detecting and treating neoplastic leasions. They might be potent enough to fill in this therapeutic demand. In this thesis Listeria monocytogenes was investigated as carrier for targeted bacterial cancer therapy. One part of the study focussed on

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24

Montes, Cobos Elena. "Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C34-F.

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25

Guerreiro, Íris Cláudia Felisberto. "Exploring new therapeutic targets and novel therapies for resistant colorectal cancer subtypes." Master's thesis, 2019. http://hdl.handle.net/10362/74793.

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Colorectal cancer (CRC) represents the fourth leading cause of death by cancer in the world. CRC treatment is determined according to disease stage. 5-fluoruracil (5-FU), oxaliplatin and Irinotecan are the main chemotherapeutic compounds used in CRC treatment in different therapeutic strategies. However, in most aggressive CRCs, cells often develop resistance mechanisms leading to ineffectiveness of these therapies. Thus, it is of great importance the better understanding of molecular mechanisms underlying CRC in order to find new therapeutic targets and novel therapeutic strategies for treati

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26

Han, Yanyan [Verfasser]. "Functional characterization of FMNL1 as potential target for novel anti-tumor therapies / vorgelegt von Yanyan Han." 2010. http://d-nb.info/1001538161/34.

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27

Ghugari, Rahul. "Histone H3 lysine 56 acetylation and deacetylation pathways as targets for novel antifungal therapies in Candida albicans." Thèse, 2018. http://hdl.handle.net/1866/21180.

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