Log in

Relevant bibliographies by topics / NRD convertase / Journal articles

To see the other types of publications on this topic, follow the link: NRD convertase.

Journal articles on the topic 'NRD convertase'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'NRD convertase.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

HOSPITAL, Véronique, Valérie CHESNEAU, Agnès BALOGH, et al. "N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface." Biochemical Journal 349, no. 2 (2000): 587–97. http://dx.doi.org/10.1042/bj3490587.

Full text

Abstract:

N-arginine (R) dibasic (NRD) convertase (nardilysin; EC 3.4.24.61), a metalloendopeptidase of the M16 family, specifically cleaves peptide substrates at the N-terminus of arginines in dibasic motifs in vitro. In rat testis, the enzyme localizes within the cytoplasm of spermatids and associates with microtubules of the manchette and axoneme. NRD1 and NRD2 convertases, two NRD convertase isoforms, differ by the absence (isoform 1) or presence (isoform 2) of a 68-amino acid insertion close to the active site. In this study, we overexpressed both isoforms, either by vaccinia virus infection of BSC

APA, Harvard, Vancouver, ISO, and other styles

2

HOSPITAL, Véronique, Annik PRAT, Catherine JOULIE, Dorra CHÉRIF, Robert DAY, and Paul COHEN. "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family." Biochemical Journal 327, no. 3 (1997): 773–79. http://dx.doi.org/10.1042/bj3270773.

Full text

Abstract:

Rat testis NRD convertase (EC 3.4.24.61) is a Zn2+-dependent endopeptidase that cleaves, in vitro, peptide substrates at the N-terminus of Arg residues in dibasic sites. This putative processing enzyme of the insulinase family of metallopeptidases exhibits a significant degree of similarity to insulinase and two yeast processing enzymes, Axl1 and Ste23. We report the cloning of two human testis cDNA species encoding isoforms of NRD convertase, hNRD1 and hNRD2. Whereas the hNRD1 transcript (3.7 kb) is equivalent to the previously characterized rat cDNA (rNRD1), hNRD2 and rNRD2 are 3.9 kb novel

APA, Harvard, Vancouver, ISO, and other styles

3

Chesneau, V., A. Prat, D. Segretain, et al. "NRD convertase: a putative processing endoprotease associated with the axoneme and the manchette in late spermatids." Journal of Cell Science 109, no. 11 (1996): 2737–45. http://dx.doi.org/10.1242/jcs.109.11.2737.

Full text

Abstract:

N-arginine dibasic convertase is a novel metalloendopeptidase which selectively cleaves at the N terminus of arginine residues in paired basic amino acids. Although present in brain and several other tissues, NRD convertase is particularly abundant in testis, where its expression appeared to be restricted to germ cells. Low levels of both mRNA and its corresponding protein were detected early in spermatogenesis. However, a marked accumulation of the protein was observed during late steps (14 to 19) of spermiogenesis. By electron microscopy, the NRD convertase immunoreactivity was localized in

APA, Harvard, Vancouver, ISO, and other styles

4

Csuhai, Eva, Maria Aparecida Juliano, Luiz Juliano, and Louis B. Hersh. "Kinetic Analysis of Spermine Binding to NRD Convertase." Archives of Biochemistry and Biophysics 362, no. 2 (1999): 291–300. http://dx.doi.org/10.1006/abbi.1998.1029.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Psatha, Maria, Andrew Winter, and Adrian R. Pierotti. "Analysis of regulatory sequences in the NRD Convertase promoter." Biochemical Society Transactions 28, no. 3 (2000): A83. http://dx.doi.org/10.1042/bst028a083b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

WINTER, Andrew G., and Adrian R. PIEROTTI. "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines." Biochemical Journal 351, no. 3 (2000): 755–64. http://dx.doi.org/10.1042/bj3510755.

Full text

Abstract:

NRD convertase (N-arginine dibasic convertase, NRD-C) is a dibasic selective metalloprotease which cleaves on the N-terminal side of an arginine residue in a dibasic pair. Abundant in endocrine tissues, the highest levels are found in testis. The mechanism whereby NRD-C expression is regulated at the transcriptional level has been examined by reporter-gene assay and electrophoretic-mobility-shift assays. Analysis of the rat and human promoters show that they are highly conserved, containing a number of motifs which may correspond to transcription-factor binding sites. The rat promoter has been

APA, Harvard, Vancouver, ISO, and other styles

7

Chesneau, V., A. R. Pierotti, A. Prat, F. Gaudoux, T. Foulon, and P. Cohen. "N-arginine dibasic convertase (NRD convertase): a newcomer to the family of processing endopeptidases. An overview." Biochimie 76, no. 3-4 (1994): 234–40. http://dx.doi.org/10.1016/0300-9084(94)90151-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Psatha, M. I., J. A. Craft, and A. R. Pierotti. "Regulation of the expression of NRD-Convertase: a novel promoter element." Biochemical Society Transactions 29, no. 5 (2001): A130. http://dx.doi.org/10.1042/bst029a130.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Psatha, M. I., and A. R. Pierotti. "Identification of a putative cell type specific repressor activity within the NRD convertase gene promoter." Biochemical Society Transactions 30, no. 1 (2002): A42. http://dx.doi.org/10.1042/bst030a042.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Fumagalli, P., M. Accarino, A. Egeo, et al. "Human NRD Convertase: A Highly Conserved Metalloendopeptidase Expressed at Specific Sites during Development and in Adult Tissues." Genomics 47, no. 2 (1998): 238–45. http://dx.doi.org/10.1006/geno.1997.5078.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

WINTER, Andrew G., and Adrian R. PIEROTTI. "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines." Biochemical Journal 351, no. 3 (2000): 755. http://dx.doi.org/10.1042/0264-6021:3510755.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Terrollion, Maxence. "Entre clercs et convertis." Religiologiques, no. 45 (2023): 113–35. http://dx.doi.org/10.7202/1113244ar.

Full text

Abstract:

L’entreprise de conversion en Huronie est souvent considérée comme l’un des plus grands succès de la Compagnie de Jésus en Amérique du Nord. En effet, non seulement les missionnaires parvinrent à fonder une véritable « Église wendate », mais ils trouvent dans les premiers convertis des figures capables de relayer le message chrétien auprès des leurs. L’article se propose donc d’analyser cet épisode de l’histoire religieuse de la Nouvelle-France au prisme des discours produits, qu’il s’agisse des missives jésuites narrant la rencontre spirituelle, des réactions face aux harangues françaises ou

APA, Harvard, Vancouver, ISO, and other styles

13

Ragab, Sherif Shaban, Subramani Swaminathan, Jaume Garcia-Amorós, Burjor Captain, and Françisco M. Raymo. "Bimolecular photoactivation of NBD fluorescence." New Journal of Chemistry 39, no. 3 (2015): 1570–73. http://dx.doi.org/10.1039/c4nj01983k.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Jagodzińska, Agnieszka. "Badania nad konwersją: nowe trendy, metody, wyzwania." Studia Judaica, no. 2 (46) (2021): 425–36. http://dx.doi.org/10.4467/10.4467/24500100stj.20.021.13664.

Full text

Abstract:

Research on Jewish Conversion: New Trends, Methods, and Challenges This review article addresses the recent popularity of studies on Jewish conversion. In particular, it examines the volume Bastards and Believers: Jewish Converts and Conversion from the Bible to the Present edited by Theodor Dunkelgrün and PawełMaciejko (Philadelphia, 2020). The author of the article suggests looking at this volume as at a representative example of recent trends, themes, methods, and challenges present in studying Jewish conversion.

APA, Harvard, Vancouver, ISO, and other styles

15

Zerez, CR, EF Jr Roth, S. Schulman, and KR Tanaka. "Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes." Blood 75, no. 8 (1990): 1705–10. http://dx.doi.org/10.1182/blood.v75.8.1705.1705.

Full text

Abstract:

Abstract Plasmodium falciparum-infected red blood cells (RBCs) are characterized by increases in the activity of glycolytic enzymes. Because nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP) are cofactors in the reactions of glycolysis and pentose phosphate shunt, we have examined NAD and NADP content in P. falciparum-infected RBCs. Although NADP content was not significantly altered, NAD content was increased approximately 10-fold in infected RBCs (66% parasitemia) compared with uninfected control RBCs. To determine the mechanism for the increase in NAD content, we examined the

APA, Harvard, Vancouver, ISO, and other styles

16

Zerez, CR, EF Jr Roth, S. Schulman, and KR Tanaka. "Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes." Blood 75, no. 8 (1990): 1705–10. http://dx.doi.org/10.1182/blood.v75.8.1705.bloodjournal7581705.

Full text

Abstract:

Plasmodium falciparum-infected red blood cells (RBCs) are characterized by increases in the activity of glycolytic enzymes. Because nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP) are cofactors in the reactions of glycolysis and pentose phosphate shunt, we have examined NAD and NADP content in P. falciparum-infected RBCs. Although NADP content was not significantly altered, NAD content was increased approximately 10-fold in infected RBCs (66% parasitemia) compared with uninfected control RBCs. To determine the mechanism for the increase in NAD content, we examined the activity

APA, Harvard, Vancouver, ISO, and other styles

17

Spivey, Garrett. "Turning to Tradition: Converts and the Making of an American Orthodox Church." Nova Religio 18, no. 3 (2014): 138–40. http://dx.doi.org/10.1525/nr.2015.18.3.138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Lucas, Phillip Charles. "Enfants Terribles: The Challenge of Sectarian Converts to Ethnic Orthodox Churches in the United States." Nova Religio 7, no. 2 (2003): 5–23. http://dx.doi.org/10.1525/nr.2003.7.2.5.

Full text

Abstract:

This article considers two case studies of collective conversions to Eastern Orthodoxy to illustrate the most pressing challenges faced by ethnic Orthodox congregations who attempt to assimilate sectarian groups into their midst. I argue that these challenges include: 1) the different understandings of ecclesiology held by former Protestant sectarians and by "cradle" Orthodox believers; 2) the pan-Orthodox aspirations of sectarian converts versus the factionalism found in ethnically-based American Orthodox jurisdictions; 3) the differing pastoral styles of former sectarian ministers and Orthod

APA, Harvard, Vancouver, ISO, and other styles

19

Gallo, Christopher M., Daniel L. Smith, and Jeffrey S. Smith. "Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity." Molecular and Cellular Biology 24, no. 3 (2004): 1301–12. http://dx.doi.org/10.1128/mcb.24.3.1301-1312.2004.

Full text

Abstract:

ABSTRACT The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase (HDAC) that functions in transcriptional silencing and longevity. The NAD+ salvage pathway protein, Npt1, regulates Sir2-mediated processes by maintaining a sufficiently high intracellular NAD+ concentration. However, another NAD+ salvage pathway component, Pnc1, modulates silencing independently of the NAD+ concentration. Nicotinamide (NAM) is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor. Pnc1 is a nicotinamidase that converts NAM to nicotinic acid. Here we show that re

APA, Harvard, Vancouver, ISO, and other styles

20

Harris, Ben G., G. S. Jagannatha Rao, David E. Coleman, G. Kulkarni, E. J. Goldsmith, and Paul F. Cook. "NAD-Malic Enzyme from Ascaris suum: Sequence and Structural Studies." Protein & Peptide Letters 7, no. 5 (2000): 297–304. http://dx.doi.org/10.2174/092986650705221207142546.

Full text

Abstract:

Abstract: Ascaris suum malic enzyme belongs to the class of oxidative decarboxylases and converts L-malate to pyruvate utilizing NAD and a divalent metal cofactor. It plays a key role in the energy metabolism of the parasite and hence is a target for chemotherapy. It has been extensively characterized from the standpoint of its kinetic, regulatory and chemical mechanisms. Recent studies involving site specific mutants and the determination of its complete sequence as well as quaternary structure have greatly facilitated elucidation of its catalytic mechanism.

APA, Harvard, Vancouver, ISO, and other styles

21

Grose, Julianne H., Ulfar Bergthorsson, and John R. Roth. "Regulation of NAD Synthesis by the Trifunctional NadR Protein of Salmonella enterica." Journal of Bacteriology 187, no. 8 (2005): 2774–82. http://dx.doi.org/10.1128/jb.187.8.2774-2782.2005.

Full text

Abstract:

ABSTRACT The three activities of NadR were demonstrated in purified protein and assigned to separate domains by missense mutations. The N-terminal domain represses transcription of genes for NAD synthesis and salvage. The C-terminal domain has nicotinamide ribose kinase (NmR-K; EC 2.7.1.22) activity, which is essential for assimilation of NmR, converting it internally to nicotinamide mononucleotide (NMN). The central domain has a weak adenylyltransferase (NMN-AT; EC 2.7.7.1) activity that converts NMN directly to NAD but is physiologically irrelevant. This central domain mediates regulatory ef

APA, Harvard, Vancouver, ISO, and other styles

22

Susan Wong, F., Irene Visintin, Li Wen, Jennifer Granata, Richard Flavell, and Charles A. Janeway. "The Role of Lymphocyte Subsets in Accelerated Diabetes in Nonobese Diabetic–Rat Insulin Promoter–B7-1 (NOD-RIP-B7-1) Mice." Journal of Experimental Medicine 187, no. 12 (1998): 1985–93. http://dx.doi.org/10.1084/jem.187.12.1985.

Full text

Abstract:

B7-1 transgene expression on the pancreatic islets in nonobese diabetic (NOD) mice leads to accelerated diabetes, with &gt;50% of animals developing diabetes before 12 wk of age. The expression of B7-1 directly on the pancreatic β cells, which do not normally express costimulator molecules, converts the cells into effective antigen-presenting cells leading to an intensified autoimmune attack. The pancreatic islet infiltrate in diabetic mice consists of CD8 T cells, CD4 T cells, and B cells, similar to diabetic nontransgenic NOD mice. To elucidate the relative importance of each of the subs

APA, Harvard, Vancouver, ISO, and other styles

23

Daniel, Carolin, Benno Weigmann, Roderick Bronson, and Harald von Boehmer. "Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope." Journal of Experimental Medicine 208, no. 7 (2011): 1501–10. http://dx.doi.org/10.1084/jem.20110574.

Full text

Abstract:

Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-Ag7 molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe a strongly agonistic insulin mimetope that effectively converts naive T cells into Foxp3+ regulatory T cells in vivo, thereby completely preventing T1D in NOD mice. In contrast, natural insulin epitopes ar

APA, Harvard, Vancouver, ISO, and other styles

24

Morita, Rimpei, Mayu Suzuki, Hidenori Kasahara, et al. "ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells." Proceedings of the National Academy of Sciences 112, no. 1 (2014): 160–65. http://dx.doi.org/10.1073/pnas.1413234112.

Full text

Abstract:

Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic disorders. In addition, the generation of ECs has become increasingly important for providing vascular plexus to regenerated organs, such as the liver. Although many attempts have been made to generate ECs from pluripotent stem cells and nonvascular cells, the minimum number of transcription factors that specialize in directly inducing vascular ECs remains undefined. Here, by screening 18 transcription factors that are important for both endothelial and hematopoietic development, we demonstrate that ets

APA, Harvard, Vancouver, ISO, and other styles

25

Liu, Hui-wen, Chadwick B. Smith, Mark S. Schmidt, et al. "Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration." Proceedings of the National Academy of Sciences 115, no. 42 (2018): 10654–59. http://dx.doi.org/10.1073/pnas.1809392115.

Full text

Abstract:

Axon degeneration, a hallmark of chemotherapy-induced peripheral neuropathy (CIPN), is thought to be caused by a loss of the essential metabolite nicotinamide adenine dinucleotide (NAD+) via the prodegenerative protein SARM1. Some studies challenge this notion, however, and suggest that an aberrant increase in a direct precursor of NAD+, nicotinamide mononucleotide (NMN), rather than loss of NAD+, is responsible. In support of this idea, blocking NMN accumulation in neurons by expressing a bacterial NMN deamidase protected axons from degeneration. We hypothesized that protection could similarl

APA, Harvard, Vancouver, ISO, and other styles

26

Kościańska, Agnieszka. "„Potęga ciszy” — z antropologicznych studiów nad genderowym wymiarem alternatywnej duchowości." Kultura i Społeczeństwo 52, no. 3 (2008): 91–108. http://dx.doi.org/10.35757/kis.2008.52.3.6.

Full text

Abstract:

The paper is based on ethnographic ﬁeldwork among converts from Catholicism to a marginal Hindu-rooted, female dominated new religious movement in Poland, the Brahma Kumaris, and explores the role of silence in the religious practices and everyday lives of its members. It argues that silence is a performative act in reconstruction of the informants’ gender identity and is perceived by them as form of self-valuation. From the perspective of the feminist discourse, particularly Western liberal feminism, as well as within cultural anthropology silence is often interpreted as a lack of power and o

APA, Harvard, Vancouver, ISO, and other styles

27

CAKIR-KIEFER, Céline, Hélène MULLER-STEFFNER, Norman OPPENHEIMER, and Francis SCHUBER. "Kinetic competence of the cADP-ribose–CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling." Biochemical Journal 358, no. 2 (2001): 399–406. http://dx.doi.org/10.1042/bj3580399.

Full text

Abstract:

CD38/NAD+ glycohydrolase is a type II transmembrane glycoprotein widely used to study T- and B-cell activation and differentiation. CD38 is endowed with two different activities: it is a signal transduction molecule and an ectoenzyme that converts NAD+ into ADP-ribose (NAD+ glycohydrolase activity) and small proportions of cADP-ribose (cADPR; ADP-ribosyl cyclase activity), a calcium-mobilizing metabolite, which, ultimately, can also be hydrolysed (cADPR hydrolase activity). The relationship between these two properties, and strikingly the requirement for signalling in the formation of free or

APA, Harvard, Vancouver, ISO, and other styles

28

Stetsenko, Artem, Rajkumar Singh, Michael Jaehme, Albert Guskov, and Dirk Jan Slotboom. "Structural and Functional Characterization of NadR from Lactococcus lactis." Molecules 25, no. 8 (2020): 1940. http://dx.doi.org/10.3390/molecules25081940.

Full text

Abstract:

NadR is a bifunctional enzyme that converts nicotinamide riboside (NR) into nicotinamide mononucleotide (NMN), which is then converted into nicotinamide adenine dinucleotide (NAD). Although a crystal structure of the enzyme from the Gram-negative bacterium Haemophilus influenzae is known, structural understanding of its catalytic mechanism remains unclear. Here, we purified the NadR enzyme from Lactococcus lactis and established an assay to determine the combined activity of this bifunctional enzyme. The conversion of NR into NAD showed hyperbolic dependence on the NR concentration, but sigmoi

APA, Harvard, Vancouver, ISO, and other styles

29

Yamaki, Shohei, and Kazuko Ishikawa. "Roles of Four Sorbitol Related Enzymes and Invertase in the Seasonal Alteration of Sugar Metabolism in Apple Tissue." Journal of the American Society for Horticultural Science 111, no. 1 (1986): 134–37. http://dx.doi.org/10.21273/jashs.111.1.134.

Full text

Abstract:

Abstract Activities and roles of 4 sorbitol enzymes, sorbitol-6-P dehydrogenase, NAD+-dependent sorbitol dehydrogenase, NADP+-dependent sorbitol dehydrogenase and sorbitol oxidase, and acid invertase in apple (Malus domestica Borkh. ‘Jonnagold’) leaves and fruit were studied. Almost all of the soluble carbohydrates in leaves are present as sorbitol throughout the season. Sorbitol-6-P dehydrogenase had the highest activity among the enzymes, being high in young leaves and decreasing with age; whereas NAD+- and NADP+-dependent sorbitol dehydrogenases and sorbitol oxidase activities were barely d

APA, Harvard, Vancouver, ISO, and other styles

30

Bai, Xue, Jing Lan, Shanru He, et al. "Structural and Biochemical Analyses of the Butanol Dehydrogenase from Fusobacterium nucleatum." International Journal of Molecular Sciences 24, no. 3 (2023): 2994. http://dx.doi.org/10.3390/ijms24032994.

Full text

Abstract:

Butanol dehydrogenase (BDH) plays a significant role in the biosynthesis of butanol in bacteria by catalyzing butanal conversion to butanol at the expense of the NAD(P)H cofactor. BDH is an attractive enzyme for industrial application in butanol production; however, its molecular function remains largely uncharacterized. In this study, we found that Fusobacterium nucleatum YqdH (FnYqdH) converts aldehyde into alcohol by utilizing NAD(P)H, with broad substrate specificity toward aldehydes but not alcohols. An in vitro metal ion substitution experiment showed that FnYqdH has higher enzyme activi

APA, Harvard, Vancouver, ISO, and other styles

31

Subedi, Amit, Qiang Liu, David Sharon, et al. "Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity Selectively Targets Human Acute Myeloid Leukemia Stem Cells." Blood 132, Supplement 1 (2018): 3932. http://dx.doi.org/10.1182/blood-2018-99-120258.

Full text

Abstract:

Abstract Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow associated with poor clinical outcomes. Conventional chemotherapies are effective in debulking the leukemic burden in most AML patients. However, a small population of disease-sustaining leukemic stem cells (LSCs) frequently persists and contributes to relapsed disease. Novel therapies that eradicate LSCs have the potential to improve clinical outcomes in AML. To discover novel anti-LSC agents, we performed a high-throughput flow cytometry-based drug screen of 1,220 compounds against a primary AML sample (8227

APA, Harvard, Vancouver, ISO, and other styles

32

Nuñez, Alberto, Thomas A. Foglia та George J. Piazza. "Cofactor recycling in a coupled enzyme oxidation–reduction reaction: conversion of ω‐oxo‐fatty acids into ω‐hydroxy and dicarboxylic acids". Biotechnology and Applied Biochemistry 29, № 3 (1999): 207–12. http://dx.doi.org/10.1111/j.1470-8744.1999.tb00550.x.

Full text

Abstract:

Aldehydes are reduced to alcohols by the enzyme alcohol dehydrogenase (ADH), whereas the enzyme aldehyde dehydrogenase (AldDH) oxidizes aldehydes to carboxylic acids. ADH and AldDH require, respectively, the reduced and oxidized forms of the cofactor NAD (NAD+/NADH). By combining both oxidation and reduction reactions into one process, it is possible to produce alcohols and carboxylic acids simultaneously from aldehydes by continuous recycling of the NAD+/NADH cofactor. However, both enzymes need to be active within the same pH region and buffer system. To test this hypothesis, the pH profile

APA, Harvard, Vancouver, ISO, and other styles

33

Reeves, Peta L. S., Rajeev Rudraraju, F. Susan Wong, Emma E. Hamilton-Williams, and Raymond J. Steptoe. "Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice." European Journal of Immunology 47, no. 9 (2017): 1550–61. http://dx.doi.org/10.1002/eji.201747089.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lukacik, Petra, Brigitte Keller, Gabor Bunkoczi, et al. "Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity." Biochemical Journal 402, no. 3 (2007): 419–27. http://dx.doi.org/10.1042/bj20061319.

Full text

Abstract:

To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17β-HSD (17β-hydroxysteroid dehydrogenase) activity. 17β-HSD enzymes are primarily involved in the metabolism of steroids at the C-17 position and also of other substrates such as fatty acids, prostaglandins and xenobiotics. In vitro, DHRS10 converts NAD+ into NADH in the presence of oestradiol, testosterone and 5-androstene-3β,17β-diol. Furthermore, the produ

APA, Harvard, Vancouver, ISO, and other styles

35

Biedermann, Julia, Matthias Preussler, Marina Conde, et al. "Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin." Cancers 11, no. 12 (2019): 2028. http://dx.doi.org/10.3390/cancers11122028.

Full text

Abstract:

IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), whereas IDH1R132H uses α-ketoglutarate and NADPH to generate the oncometabolite 2-hydroxyglutarate (2-HG). While the effects of 2-HG have been the subject of intense research, the 2-HG independent effects of IDH1R132H are still ambiguous. The present study demonstrates that IDH1R132H expression but not 2-HG alone leads to significantly decreased tricarboxylic acid (TCA) cycle m

APA, Harvard, Vancouver, ISO, and other styles

36

Wang, Feng-Sheng, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, and Wei-Shiung Lian. "Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics." Antioxidants 10, no. 9 (2021): 1394. http://dx.doi.org/10.3390/antiox10091394.

Full text

Abstract:

Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis. Mitochondrial glycolysis and oxidative phosphorylation pathways together with ROS generation meet the energy requirement for bone-forming cell growth and differentiation, respectively. Moderate mechanical stimulations, such as weight loading, physical activity, ultrasound, vibration, and electromagnetic field stimulation, etc., are advantageous to bone-forming cell activity, promoting bone anabolism to compromise osteo

APA, Harvard, Vancouver, ISO, and other styles

37

Batsios, Georgios, Celine Taglang, Meryssa Tran, Anne Marie Gillepspie, and Pavithra Viswanath. "TMET-20. TERT ACTS VIA FOXO1 TO ALTER REDOX METABOLISM IN BRAIN TUMORS." Neuro-Oncology 24, Supplement_7 (2022): vii265—vii266. http://dx.doi.org/10.1093/neuonc/noac209.1025.

Full text

Abstract:

Abstract Telomere maintenance is a fundamental hallmark of cancer. Most tumors maintain telomere length via reactivation of telomerase reverse transcriptase (TERT) expression. Identifying imaging biomarkers of TERT can enable non-invasive assessment of tumor proliferation and response to therapy. Deuterium magnetic resonance spectroscopy (DMRS) following administration of 2H-labeled substrates recently emerged as a novel, clinically translatable method of monitoring metabolic activity in vivo. The goal of this study was to delineate metabolic reprogramming associated with TERT expression and t

APA, Harvard, Vancouver, ISO, and other styles

38

Balakin, V., V. Mashinistov, and A. Koveria. "Perspective technology of recycling of radioactive contaminated metal based on its melting." Nuclear and Radiation Safety, no. 2(78) (June 7, 2018): 43–48. http://dx.doi.org/10.32918/nrs.2018.2(78).07.

Full text

Abstract:

Melting of the radioactively contaminated metal converts it as a source of ionizing radiation from a surface distribution of radionuclides into the source with their volume distribution. From the surface of the melted metal gamma radiation of a part of radionuclides is emitted, which are in its scope. Alpha and beta radiation are absorbed completely in the metal. To obtain a radiation-safe metal it is necessary that the amount of gamma-emitting radionuclides, which are loaded into the furnace together with the charge, did not exceed the established allowable level. The radiation sa

APA, Harvard, Vancouver, ISO, and other styles

39

Immergut, Matthew. "Death at Diamond Mountain." Nova Religio 17, no. 1 (2013): 24–37. http://dx.doi.org/10.1525/nr.2013.17.1.24.

Full text

Abstract:

For the past five years, I have engaged in fieldwork and filming a documentary about Diamond Mountain, a community of Western converts to Tibetan Buddhism in southern Arizona under the leadership of Geshe Michael Roach and Lama Christie McNally. The latter was retreat master and, along with her husband Ian Thorson, in the middle of guiding forty students through a three-year, three-month, three-day silent meditation retreat. But when McNally stabbed Thorson, the Diamond Mountain Board asked both to leave. Feigning departure, the couple sneaked into a small cave just outside the Diamond Mountai

APA, Harvard, Vancouver, ISO, and other styles

40

Pampa, Kudigana J., Neratur K. Lokanath, Naoki Kunishima, and Ravishankar Vittal Rai. "The first crystal structure of NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase fromThermus thermophilusHB8." Acta Crystallographica Section D Biological Crystallography 70, no. 4 (2014): 994–1004. http://dx.doi.org/10.1107/s1399004713034925.

Full text

Abstract:

2-Keto-3-deoxygluconate (KDG) is one of the important intermediates in pectin metabolism. An enzyme involved in this pathway, 3-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (DDGDH), has been identified which converts 2,5-diketo-3-deoxygluconate to KDG. The enzyme is a member of the short-chain dehydrogenase (SDR) family. To gain insight into the function of this enzyme at the molecular level, the first crystal structure of DDGDH fromThermus thermophilusHB8 has been determined in the apo form, as well as in complexes with the cofactor and with citrate, by X-ray diffraction methods. The crystal s

APA, Harvard, Vancouver, ISO, and other styles

41

Providenti, Miguel A., Jason M. O'Brien, Jürgen Ruff, Alasdair M. Cook, and Iain B. Lambert. "Metabolism of Isovanillate, Vanillate, and Veratrate by Comamonas testosteroni Strain BR6020." Journal of Bacteriology 188, no. 11 (2006): 3862–69. http://dx.doi.org/10.1128/jb.01675-05.

Full text

Abstract:

ABSTRACT In Comamonas testosteroni strain BR6020, metabolism of isovanillate (iVan; 3-hydroxy-4-methoxybenzoate), vanillate (Van; 4-hydroxy-3-methoxybenzoate), and veratrate (Ver; 3,4-dimethoxybenzoate) proceeds via protocatechuate (Pca; 3,4-dihydroxybenzoate). A 13.4-kb locus coding for the catabolic enzymes that channel the three substrates to Pca was cloned. O demethylation is mediated by the phthalate family oxygenases IvaA (converts iVan to Pca and Ver to Van) and VanA (converts Van to Pca and Ver to iVan). Reducing equivalents from NAD(P)H are transferred to the oxygenases by the class I

APA, Harvard, Vancouver, ISO, and other styles

42

Skory, Christopher D. "Isolation and Expression of Lactate Dehydrogenase Genes from Rhizopus oryzae." Applied and Environmental Microbiology 66, no. 6 (2000): 2343–48. http://dx.doi.org/10.1128/aem.66.6.2343-2348.2000.

Full text

Abstract:

ABSTRACT Rhizopus oryzae is used for industrial production of lactic acid, yet little is known about the genetics of this fungus. In this study I cloned two genes, ldhA and ldhB, which code for NAD+-dependent l-lactate dehydrogenases (LDH) (EC 1.1.1.27 ), from a lactic acid-producing strain of R. oryzae. These genes are similar to each other and exhibit more than 90% nucleotide sequence identity and they contain no introns. This is the first description of ldh genes in a fungus, and sequence comparisons revealed that these genes are distinct from previously isolated prokaryotic and eukaryotic

APA, Harvard, Vancouver, ISO, and other styles

43

Homer, Michael W. "Seeking Primitive Christianity in the Waldensian Valleys: Protestants, Mormons, Adventists and Jehovah's Witnesses in Italy." Nova Religio 9, no. 4 (2006): 5–33. http://dx.doi.org/10.1525/nr.2006.9.4.005.

Full text

Abstract:

During the nineteenth century, Protestant clergymen (Anglican, Presbyterian, and Baptist) as well as missionaries for new religious movements (Mormons, Seventh-day Adventists and Jehovah's Witnesses) believed that Waldensian claims to antiquity were important in their plans to spread the Reformation to Italy. The Waldensians, who could trace their historical roots to Valdes in 1174, developed an ancient origins thesis after their union with the Protestant Reformation in the sixteenth century. This thesis held that their community of believers had preserved the doctrines of the primitive church

APA, Harvard, Vancouver, ISO, and other styles

44

Murken, Sebastian, and Sussan Namini. "Childhood Familial Experiences as Antecedents of Adult Membership in New Religious Movements: A Literature Review." Nova Religio 10, no. 4 (2007): 17–37. http://dx.doi.org/10.1525/nr.2007.10.4.17.

Full text

Abstract:

Is it possible to identify specific familial patterns as antecedents of adult membership in new religious movements? Can the choice of an NRM be predicted by the childhood experiences of individuals joining such movements? This international literature review seeks to answer these questions, investigating the assumption that early family experiences affect adults' decisions to join NRMs. It includes empirical studies that have been written in English, German and French since 1970, and gives an overview of findings on childhood family structures, including parents and siblings, as well as early

APA, Harvard, Vancouver, ISO, and other styles

45

Kempster, Sarah L., Gusztav Belteki, Alison J. Forhead, et al. "Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 300, no. 2 (2011): G253—G263. http://dx.doi.org/10.1152/ajpgi.00397.2010.

Full text

Abstract:

The inflammasome is a multiprotein complex whose formation is triggered when a NOD-like receptor binds a pathogen ligand, resulting in activated caspase-1, which converts certain interleukins (IL-1β, IL-18, and IL-33) to their active forms. There is currently no information on regulation of this system around the time of birth. We employed transcript profiling of fetal rat intestinal and lung RNA at embryonic days 16 (E16) and 20 (E20) with out-of-sample validation using quantitative RT-PCR. Transcript profiling and quantitative RT-PCR demonstrated that transcripts of core components of the NO

APA, Harvard, Vancouver, ISO, and other styles

46

Taneera, Jalal, Emma Smith, Mikael Sigvardsson, et al. "Notch Activation Converts B Cells into a T Cell Fate at the Earliest Stages of B Cell Committed Progenitors." Blood 106, no. 11 (2005): 3151. http://dx.doi.org/10.1182/blood.v106.11.3151.3151.

Full text

Abstract:

Abstract Notch activation has been suggested to promote T cell development at the expense of B cell commitment at the level of a common lymphoid progenitor prior to B cell commitment. Here, we explored the possibility that Notch activation might be able to switch the fate of already committed B cell progenitors towards T cell development upon Notch activation. To address this we overexpressed constitutively activated Notch-3 (N3IC) in B cell progenitors purified from transgenic mice in which human CD25 is expressed under control of the λ5 promoter. Strikingly, whereas untransduced and control

APA, Harvard, Vancouver, ISO, and other styles

47

Hattula, M. Tapani, Harriet C. Wallin, R. Andersen, et al. "Enzymatic Determination of Free Glutamic Acid in Dried Soups and in Minced Sausages: NMKL1 Collaborative Study." Journal of AOAC INTERNATIONAL 74, no. 6 (1991): 921–25. http://dx.doi.org/10.1093/jaoac/74.6.921.

Full text

Abstract:

Abstract An enzymatic method for the determination of free glutamic acid in meat products and dried soups was collaboratively studied in 11 laboratories. In the presence of the enzyme glutamate dehydrogenase, L-giutamic acid is oxidatively deaminated by nicotinamide adenine dinucleotide (NAD) to 2-oxoglutarate. In a reaction catalyzed by diaphorase, the NADH thus formed converts 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride to a formazan, which is measured in the visible range at 492 nm. Fourteen samples (7 samples of minced sausage and 7 samples of dried cauliflower soup) wi

APA, Harvard, Vancouver, ISO, and other styles

48

Chung, Cheng-Chih, Yu-Hsun Kao, Yao-Chang Chen, et al. "PCSK9 Enhances Cardiac Fibrogenesis via the Activation of Toll-like Receptor and NLRP3 Inflammasome Signaling." International Journal of Molecular Sciences 26, no. 5 (2025): 1921. https://doi.org/10.3390/ijms26051921.

Full text

Abstract:

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel target for reducing low-density lipoprotein cholesterol. PCSK9 activates the atherosclerosis process through pro-inflammation signaling. Furthermore, the serum level of PCSK9 is positively correlated with mortality in patients with heart failure (HF). Cardiac fibrosis plays a crucial role in the pathophysiology of HF. In this study, we intended to examine whether PCSK9 can increase fibroblast activities and explore what its underlying mechanisms are. Migration, proliferation analyses, and Western blotting were used on

APA, Harvard, Vancouver, ISO, and other styles

49

Dachevsky, Fernando. "Acumulación de capital y particularidades en el nacionalismo petrolero argentino." Anuario Centro de Estudios Económicos de la Empresa y el Desarrollo, no. 18 (February 3, 2022): 23–54. http://dx.doi.org/10.56503/anuario/nro.18(14)pp.23-54.

Full text

Abstract:

Los procesos de nacionalización aparecen de manera recurrente en la historia petrolera mundial. Se trata por ello de un sector que tiende a convertirse en causa del nacionalismo. El presente trabajo se propone examinar particularidades del nacionalismo petrolero argentino. Para ello analizamos sus principales elaboraciones intelectuales a luz de los conflictos principales que generaba la acumulación de capital en dicho sector. Buscamos así identificar desde qué problemáticas se formuló la necesidad de la nacionalización del petróleo en este país. Recuperando la experiencia de los princip

APA, Harvard, Vancouver, ISO, and other styles

50

M, A. Sayyad, and S. Agarkar B. "Modified Architecture for Nikhilam Navatshcaramam Dashath (NND) Vedic Multiplier." Indian Journal of Science and Technology 16, no. 42 (2023): 3727–34. https://doi.org/10.17485/IJST/v16i42.733.

Full text

Abstract:

Abstract <strong>Objectives:</strong> Speed of multiplication in Digital Signal Processing (DSP) applications plays an important role in generating the result quickly. There is scope for reducing the propagation delay in multiplication by designing the multiplier circuit based on the Vedic mathematics (formulas) sutras. This study aims to design the multiplier circuit based on Nikhilam Navatshcaramam Dashath (NND) of Vedic mathematics for improvement in speed, power, and area. <strong>Methods:</strong> The multiplier circuit based on NND method is designed for the multiplier and

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!