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Dissertations / Theses on the topic 'NSXA'

Author: Grafiati

Published: 10 January 2023

Last updated: 31 July 2025

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1

Stone, Michael H. "North Carolina State NSCA Meeting." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etsu-works/4488.

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2

Snell, Jay. "Deep freeze and the NSSA labs /." Online version of thesis, 2009. http://hdl.handle.net/1850/9589.

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3

Kashfi, S. Ruhollah. "Towards Evaluation of the Adaptive-Epsilon-R-NSGA-II algorithm (AE-R-NSGA-II) on industrial optimization problems." Thesis, Högskolan i Skövde, Institutionen för ingenjörsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-10841.

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Simulation-based optimization methodologies are widely applied in real world optimization problems. In developing these methodologies, beside simulation models, algorithms play a critical role. One example is an evolutionary multi objective optimization algorithm known as Reference point-based Non-dominated Sorting Genetic Algorithm-II (R-NSGA-II), which has shown to have some promising results in this regard. Its successor, R-NSGA-II-adaptive diversity control (hereafter Adaptive Epsilon-R-NSGA-II (AE-R-NSGA-II) algorithm) is one of the latest proposed extensions of the R-NSGA-II algorithm an

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4

Gran, Mikael, and Claes Karlsson. "Survey of VMware NSX Virtualized Network Platform : Utvärdering av VMware NSX Virtualized Network Platform." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-35596.

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Atea Eskilstuna hade behovet av en plattform som kan förenkla och minska antalet konfigurationer vid implementation av kunder. Arbetet gick ut på att utvärdera plattformen VMware NSX och jämföra det mot traditionella nätverkslösningar. I dagens datacenter är virtualisering en viktig del av dess verksamhet. Användandet av virtualisering optimerar hanteringen av hårdvaru-resurser och kostnader. Virtualisering har hittills främst fokuserat på hantering av servrar och klienter, vilket har passerat nätverksutvecklingen, och därför har det uppstått vissa problem med traditionella datacenter gällande

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5

Wu, Jun Jie. "Distributed CubeSats Network Routing Optimization using NSGA-II." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14560.

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Multi-objective optimization knows a fast growing interest for both academic researches and real-life problems. An important domain is the satellite routing problems. In this thesis, I designed network topologies using Matlab for two hundred of low earth orbit (LEO) CubeSats constellations. NSGA-II is a non-dominated sorting genetic algorithm which consists of multi-objective functions. NSGA-II algorithm starts with a random population. Each individual in population is considered as a chromosome. Three objective functions were considered in this paper: Hot count, Delay and Bandwidth. Final sol

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6

Grimm, Christian [Verfasser], Robert [Gutachter] Tampé, and Christoph [Gutachter] Welsch. "Charakterisierung des Lipidbindungsverhaltens und der Proteinfaltung von HCV NS5A unter Einfluss des NS5A-Inhibitors Daclatasvir / Christian Grimm ; Gutachter: Robert Tampé, Christoph Welsch." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1239730276/34.

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7

Dias, Tiago Fouchy. "Otimização multiobjetivo de uma máquina pentafásica utilizando NSGA-II." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/156471.

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Neste trabalho é desenvolvida uma metodologia de otimização multiobjetivo baseada no NSGA-II (Nondominated Sorting Genetic Algorithm), a qual visa a otimização do projeto de máquinas de indução pentafásicas. A escolha deste tipo de máquina se justifica pelo fato de que elas apresentam vantagens importantes quando comparadas com as trifásicas convencionais, tais como maior potência e maior torque para um mesmo volume de material ativo, além da possibilidade de operar na ocorrência de falhas (perda de uma ou duas fases). Na otimização de máquinas de indução vários objetivos podem ser definidos,

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8

Gerdhem, Lovisa. "Cloning and Expression of TBEV NS4A in A549 cells." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-78018.

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Background: Tick borne Encephalitis Virus (TBEV), the cause of the fatal Central Nervous System (CNS) infection Tick Borne Encephalitis (TBE), belongs to the family of Flaviviridae and the genusFlavivirus. In order to replicate themselves, they cause the formation of a replication complex, which is nestled inside vesicles of the Endoplasmic Reticulum (ER) membrane to protect the RNA from host defense mechanisms. These membrane vesicles are created by the interaction of viral nonstructural proteins and host proteins. The nonstructural protein, NS4A, is believed to play an important part in the

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9

Zamani, Iman. "Optimal distributed generation planning based on NSGA-II and MATPOWER." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11483.

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The UK and the world are moving away from central energy resource to distributed generation (DG) in order to lower carbon emissions. Renewable energy resources comprise a big percentage of DGs and their optimal integration to the grid is the main attempt of planning/developing projects with in electricity network. Feasibility and thorough conceptual design studies are required in the planning/development process as most of the electricity networks are designed in a few decades ago, not considering the challenges imposed by DGs. As an example, the issue of voltage rise during steady state condi

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10

Baltz, Andre. "Merkel med NSA på andra sidan luren." Thesis, Umeå universitet, Institutionen för kultur- och medievetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84848.

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Title: Merkel with NSA on the telephone The aim of this essay is to study how Angela Merkel is being portrayed in context of NSAs surveillance in the Swedish newspapers Dagens Nyheter and Aftonbladet. The time period for the study is from the 24th of October to the 7th of November in the autumn of 2013. To concretize the aim three questions was formulated, how Angela Merkel was being portrayed in the material, how NSAs surveillance of Angela Merkel was being portrayed in the material and how different statements for various individuals in the material could affect the truth about the surveilla

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11

Magsombol, Anacleto M. "Navy Stock Account (NSA) material expenditure errors." Thesis, Monterey, California. Naval Postgraduate School, 1990. http://hdl.handle.net/10945/37518.

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Approved for public release; distribution is unlimited<br>This thesis was an investigation of the causes that prevented large numbers of Pacific Fleet units' NSA expenditures from processing through the Fleet Resource Accounting Module (FRAM) at the Fleet Accounting and Disbursing Center Pacific (FAADCPAC), San Diego, CA. Six consecutive months' NSA expenditure errors from December 1989 to May 1990 were used in the analysis. The researcher concluded that the major cause of the problem was the use of wrong fund codes by the fleet units when they requisitioned their materials from the shore supp

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12

Shinma, Taís Arriero. "Calibração multiobjetivo do SWMM aplicada à transformação chuva-vazão." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-18072011-135212/.

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Um calibrador automático multiobjetivo para o Storm Water Management Model (SWMM) foi desenvolvido utilizando o método de otimização multiobjetivo Non Dominated Sorting Genetic Algorithm (NSGA II) com elistismo controlado (Deb & Goel, 2001). O programa utiliza o código fonte do SWMM na etapa de avaliação das soluções, para determinar o valor das vazões simuladas, utilizado no cálculo das funções objetivo (FOs). Os testes do calibrador foram aplicados a dois sistemas diferentes, sendo o primeiro uma bacia exemplo hipotética disponibilizada no pacote de instalação do SWMM e o segundo a bacia do

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13

QUINTAVALLE, MANUELA. "Identification of cellular kinases responsible for Hepatitis C Virus NS5A hyperphosphorylation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/595.

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Hepatitis C virus (HCV) has been the subject of intensive studies for nearly two decades. Nevertheless, some aspect of the virus life cycle are still a mystery. The HCV Nonstructural protein 5A (NS5A) has been shown to be a modulator of cellular processes possibly required for the establishment of viral persistence. NS5A is heavily phosphorylated, and a switch between a basally phosphorylated form of NS5A (p56) and a hyperphosphorylated form of NS5A (p58) seems to play a pivotal role in regulating HCV replication. Efficient replication of HCV subgenomic RNA in cell culture requires the

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14

Marongiu, Michela. "Studies on the hyperphosphorylation of hepatitis C virus non structural protein NSSA." Thesis, University of Southampton, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548251.

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15

DEIBEL, CHARLES LOUIS II. "NSA DATA COLLECTION PROGRAM: THE CHALLENGE OF ASSESING EFFECTIVENESS." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613829.

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The National Security Agency (NSA) has played a key role in the United States Government’s counterterror program since September 11. Over the last 15 years, the NSA has faced considerable controversy regarding its counterterrorism data collection program and the legal authority behind it. This paper, however, is concerned with whether or not that program has been effective in preventing Islamist related or inspired terror attacks inside the United States. As NSA capabilities and authorities have expanded since 9/11, has it been effective in helping to prevent attacks in the U.S.? Definitively

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16

Oliva, Cíntia Bittar [UNESP]. "Evolução das quasiespécies da proteína NS5A do vírus da hepatite C genótipo 3a." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/102747.

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Made available in DSpace on 2014-06-11T19:32:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-24Bitstream added on 2014-06-13T19:21:44Z : No. of bitstreams: 1 oliva_cb_dr_sjrp.pdf: 1844534 bytes, checksum: 40948c5116118b7b10a75b5b44e849cc (MD5)<br>A Hepatite C é uma doença presente em todo o mundo. O vírus da Hepatite C (HCV), o agente etiológico dessa doença, é um vírus de RNA de fita simples positiva. Seu genoma codifica uma única poliproteína precursora que após processamento origina dez proteínas virais. A NS5A, uma das proteínas virais não estruturais, esta associada com a r

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17

Street, Andrew A. "Activation of phosphatidylinositol 3-kinase signalling by the hepatitis C virus NS5A protein." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417733.

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18

Kelly, Lorna Jane. "Development of tools to investigate resistance of HCV genotype 3 to NS5A inhibitors." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19307/.

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HCV infection leads to liver failure. Genotype 3 (GT3) is known to respond poorly to newly-developed direct-acting antivirals, especially inhibitors of the multifunctional NS5A protein. This work reports the establishment of efficient transient replication of the S52 GT3 sub-genomic replicon (SGR) by further culture adaptation of S52 in the context of an optimised luciferase reporter. Also documented is the development of hepatoma cells with immune-attenuating modifications and expressing the lipid binding factor hSEC14L2 to support transient replication of S52. In parallel, stable replication

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19

Oliva, Cíntia Bittar. "Evolução das quasiespécies da proteína NS5A do vírus da hepatite C genótipo 3a /." São José do Rio Preto : [s.n.], 2012. http://hdl.handle.net/11449/102747.

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Orientador: Paula Rahal<br>Coorientador: Isabel Maria Vicente Guedes de Carvalho Mello<br>Banca: Flora Maria de Campos Fernandes<br>Banca: Camila Malta Romano<br>Banca: Adriano Mondini<br>Banca: Maria Tercília Vilela de Azeredo Oliveira<br>Resumo: A Hepatite C é uma doença presente em todo o mundo. O vírus da Hepatite C (HCV), o agente etiológico dessa doença, é um vírus de RNA de fita simples positiva. Seu genoma codifica uma única poliproteína precursora que após processamento origina dez proteínas virais. A NS5A, uma das proteínas virais não estruturais, esta associada com a resposta ao tra

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20

Taveneau, Cyntia. "Modélisation, purification et caractérisation des modules et domaines de la PI4KA humaine." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114827/document.

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La phosphatidylinositol-4-kinase de type IIIα est une kinase de lipide eukaryote ubiquitaire qui synthétise le phosphatidylinositol-4-phosphate PtdIns(4)P de la membrane plasmique. Ce phosphoinositide est d’autant plus important qu’il tient un rôle majeur dans différentes voies de signalisation cellulaire, le traffic vésiculaire ainsi que dans l’identité des organelles. De plus, la PIK4A humaine est un facteur essentiel pour la réplication du virus de l’hépatite C (VHC). En effet, le recrutement du complexe de réplication du VHC par la protéine virale NS5A à la membrane du reticulum endoplasmi

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21

Kronauer, Jörg. "Beziehungen am Scheideweg? : Die NSA-Affäre und das deutschamerikanische Verhältnis." Universität Potsdam, 2014. http://opus.kobv.de/ubp/volltexte/2014/7184/.

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Enthüllungen über groß angelegte NSA-Lauschangriffe auf die Bundesrepublik, die auch vor dem Mobiltelefon der Bundeskanzlerin nicht haltmachten, haben mit neuer Intensität nicht nur die Frage nach dem deutsch-amerikanischen Verhältnis auf die Tagesordnung gesetzt. Bedeutet diese Massenspionage, dass Grundrechte in Deutschland von auswärtigen Diensten umstandslos außer Kraft gesetzt werden können? Oder ist sie der Vorbote eines aufziehenden Hegemonialkonflikts zwischen der EU und den USA?

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22

Taube, Stefan. "Charakterisierung des Hepatitis-Virus NS5A-Proteins als funktionalen Inhibitor der Interferon induzierten antiviralen Immunantwort." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2006/75/index.html.

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23

Shelton, Holly Ann. "Hepatitis C virus NS5A poly-proline motif interactions with cellular proteins containing SH3 domains." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435924.

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24

Yin, Chunhong. "Functional analysis of domain I of the hepatitis C virus non-structural NS5A protein." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20605/.

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The research on hepatitis C virus protein NS5A has developed rapidly over the decades, primarily with the advent of the JFH1 cell culture infectious clone which allowed the study of all aspects of the virus lifecycle from entry to exit. As the important target of DAAs, the NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and assembly. NS5A comprises three domains, of these domain I is believed to be involved exclusively in genome replication. In contrast, domains II and III are required for the production of infectious virus particles and are largely dispens

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25

François, Catherine. "Étude des relations entre la protéine NS5A du VHC, l'apoptose et le système interféron." Paris 6, 2002. http://www.theses.fr/2002PA066147.

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26

REGHELLIN, VERONICA. "Studies on the mechanism of action of antiviral agents targeting the replication complex of hepatitis c virus." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52708.

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At the moment, several companies are studying the clinical potential of different all-oral combinations of direct-acting antivirals in ongoing studies. The most promising interferon-free combination therapies that are on the horizon include linear or cyclic NS3/4A protease inhibitors, nucleoside as well as non-nucleoside NS5B polymerase inhibitors , and NS5A inhibitors. DAAs that target NS3/4A (protease) and NS5B (RNA-dependent RNA polymerase) inhibit the enzymatic activity of these proteins. NS5A replication complex inhibitors will likely form a component of future interferon-free dru

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27

Frazão, Pedro Henrique Oliveira. "Um big brother global? os programas de vigilância da NSA à luz da securitização dos espaços sociotecnológicos." Universidade Estadual da Paraíba, 2016. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2679.

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Submitted by Elesbão Santiago Neto (neto10uepb@cche.uepb.edu.br) on 2016-11-28T19:41:12Z No. of bitstreams: 1 PDF - Pedro Henrique Oliveira Frazão.pdf: 4658431 bytes, checksum: 260a8a4c2c26522f583a576972d4ce10 (MD5)<br>Made available in DSpace on 2016-11-28T19:41:12Z (GMT). No. of bitstreams: 1 PDF - Pedro Henrique Oliveira Frazão.pdf: 4658431 bytes, checksum: 260a8a4c2c26522f583a576972d4ce10 (MD5) Previous issue date: 2016-05-19<br>CAPES<br>The increasing use of cyberspace in International Relations is providing a new scenario for world politics. The evolution of digital media has provided

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28

Paterson, Morris. "Inhibition of the cellular responses to interferon alpha by the hepatitis C virus NS5A protein." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325537.

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29

Foster, Toshana Lauria. "Structural and functional characterisation of the hepatitis C virus proteins p7, Ns2-3 and Ns5A." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531627.

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30

Taylor, Annette Irene. "The intracellular localisation and membrane-altering properties of hepititis C virus proteins NS4B and NS5A." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274768.

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31

McKechnie, Victoria Margaret. "Variation in the NS5A gene of Hepatitis C Virus in response to interferon alpha therapy." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301364.

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32

Cesarec, Mia. "Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the interferon response." Thesis, Open University, 2017. http://oro.open.ac.uk/49307/.

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Hepatitis C virus (HCV) is a hepatotropic virus affecting more than 150 million people worldwide. HCV establishes a chronic infection in the majority of cases, which leads to severe liver complications such as cirrhosis and hepatocellular carcinoma. Fortunately, recent potent direct acting antivirals can now cure the infection. However, such treatments can induce resistance, are extremely costly limiting their use to wealthier countries and are ineffective for the complications of the infection. Therefore, a better understanding of the interaction of HCV with the host cell remains a priority b

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33

Sjölin, Andreas, and Johanna Mårtensson. "Den strävsamma bonden och andra berättelser. En diskursiv studie av ska?nska hembygdsfo?reningars historiebruk." Thesis, Malmö högskola, Fakulteten för lärande och samhälle (LS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-28109.

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The subject for this thesis is to examine the portrayal of the local farmer in four different museums in Scania. The purpose is to examine these two questions:1.Which narrative and museal strategies are used in the portrayal of the local farmer by the local history societies?2.How do the actors of the local societies relate to the living conditions and hierarchies of the rural society of Scania?The source material consists of guided tours and text material from the museums. The theoretical fields consists of history culture, use of history, historical narrative, museology and rural science act

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34

Sullivan, Edward David Kenneth. "Investigating the role of NS5A domain III in protecting the hepatitis C virus replication complex." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422266/.

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As a positive sense RNA virus, the Hepatitis C virus makes use of a membrane enclosed replication complex (RC) to replicate its genome in a protected manner. As part of a separate project attempting to visualise the RC, a fluorescent peptide, clover, and a Dihydrofolate reductase (DHFR) destabilizing domain was inserted into the NS5A coding region of a JFH1 replicon. Unexpectedly it was found that the insertion site significantly influenced RNA replication. Under conditions where the DHFR domain was destabilized, insertion within domain III inhibited replication, while insertion at the carboxy

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Maqbool, Muhammad Ahmad. "Etude de l’impact de la variabilité génétique de la protéine NS5A du virus de l’hépatite C dans la pathogenèse et la réplication virale." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0026/document.

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Le virus de l’Hépatite C (VHC), de la famille Flaviviridae, est à l’origine d’une pandémiemondiale. L’infection par le VHC provoque le dévelopment d’hépatites chroniques, decirrhoses et de carcinomes hépatocellulaires (CHC). Les fonctions de la majorité des protéinesvirales sont connues, mis à part pour NS5A dont la seule fonction directe attribuée à ce jour,équivaut à celle d’un facteur d'activation transcriptionnelle. Notre laboratoire a montréprécédemment que les variants de quasiespèce de NS5A isolés à partir du sérum d’un mêmepatient présentaient des différences significatives dans leurs

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Haggerty, Leonard. "A Profile of Strength and Conditioning Coaches at National Collegiate Athletic Association Division II and III Member Institutions." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1094.

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The purposes of this study were to compile demographic characteristics, educational backgrounds, coaching experiences, and duties of strength and conditioning (STC) coaches at NCAA Division II and III institutions, and compare the profile of Division II and III STC coaches to the Martinez (2004) study of Division I-A STC coaches. NCAA Division II and Division III athletic personnel (N=578) received an electronic survey for this study. The return rate from Division II and Division III STC coaches were as follows: Division II, 23 responses (n=175), Division III, 34 responses (n=403). Descripti

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Jardim, Ana Carolina Gomes [UNESP]. "Análise das quasiespécies do vírus da hepatite C genótipo 1 por meio da região genômica NS5A." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102745.

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Made available in DSpace on 2014-06-11T19:32:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-25Bitstream added on 2014-06-13T20:03:27Z : No. of bitstreams: 1 jardim_acg_dr_sjrp.pdf: 1650863 bytes, checksum: 6ecdc00802358d3e90fac9c3024108d4 (MD5)<br>A composição de quasiespécies do vírus da Hepatite C (HCV) pode ter implicações importantes com relação à persistência viral e à resposta a terapia baseada em Interferon. A região NS5A completa foi analisada para avaliar se a composição de quasiespécies do HCV 1a/1b está relacionada à resposta ao tratamento combinado de interferon peg

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Plante, Martin. "Caractérisation moléculaire et antigénique de la protéine NspA des Neisseriaceae et induction d'une réponse immunitaire mucosale." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ65427.pdf.

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39

Martin, Morgan Mackensie. "Functional analysis of hepatitis C virus non-structural protein (NS) 3 protease and viral cofactor NS4A." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1522.

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The hepatitis C virus (HCV) was identified in 1989 as the major causative agent of transfusion-associated non-A, non-B hepatitis and today represents a worldwide health crisis with prevalence estimates of 2.2%. HCV-specific therapeutics have never been more urgently needed. One of the validated drug targets is the non-structural (NS) protein 3 (NS3) membrane-bound protease. The major aim of this thesis was characterization of NS3 allosteric activation by its viral cofactor, NS4A. We hypothesized that there would be specific residues that dominate the interaction between NS3 and NS4A, and furth

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Winzösch, Christina Verfasser], Dieter [Akademischer Betreuer] [Willbold, and Henrike [Akademischer Betreuer] Heise. "Strukturelle Untersuchung der Interaktion zwischen HCV NS5A und Bin1 / Christina Winzösch. Gutachter: Dieter Willbold ; Henrike Heise." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1064974074/34.

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MORAES, Nadime Mustafa. "Modelo matemático para otimização multiobjetivo do despacho econômico ambiental de usinas térmicas usando o NSGA-II." Universidade Federal do Pará, 2017. http://repositorio.ufpa.br/jspui/handle/2011/9471.

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Jardim, Ana Carolina Gomes. "Análise das quasiespécies do vírus da hepatite C genótipo 1 por meio da região genômica NS5A /." São José do Rio Preto : [s.n.], 2011. http://hdl.handle.net/11449/102745.

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Resumo: A composição de quasiespécies do vírus da Hepatite C (HCV) pode ter implicações importantes com relação à persistência viral e à resposta a terapia baseada em Interferon. A região NS5A completa foi analisada para avaliar se a composição de quasiespécies do HCV 1a/1b está relacionada à resposta ao tratamento combinado de interferon peguilado (PEGIFN) e ribavirina. Seiscentos e noventa seqüências correspondentes a região não estrutural 5A (NS5A) completa foram geradas a partir de amostras coletadas antes, durante a após a administração da terapia de pacientes respondedores, não responded

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Burkart-Solyom, Zsofia. "NMR methods for intrinsically disordered proteins : application to studies of NS5A protein of hepatitis C virus." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENY077/document.

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Les protéines intrinsèquement désordonnées sont caractérisées par un manque de structure 3D stable et sont biologiquements actives dans cet état. La spectroscopie RMN est la méthode de choix pour leurs études à une résolution atomiques, car la cristallographie aux rayons X ne permet pas leur étude en raison de leur caractère hautement dynamique.Cependant, l'étude par spectroscopie RMN de ces protéines est difficiles à cause du grand nombre de recouvrement entre les signaux dans le spectre résultant de l'absence d'un réseau de liaison hydrogène qui pourrait stabiliser la structure et permettre

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Winzösch, Christina [Verfasser], Dieter [Akademischer Betreuer] Willbold, and Henrike [Akademischer Betreuer] Heise. "Strukturelle Untersuchung der Interaktion zwischen HCV NS5A und Bin1 / Christina Winzösch. Gutachter: Dieter Willbold ; Henrike Heise." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1064974074/34.

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Badillo, Aurélie. "Analyses structurales et fonctionnelles de la protéine non-structurale 5A (NS5A) du virus de l’hépatite C." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10239.

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La protéine NS5A est essentielle pour la réplication et l'assemblage du virus de l'hépatite C (VHC), et elle constitue une cible thérapeutique prometteuse pour le développement d'antiviraux. Cependant, aucune fonction claire n'a encore été décrite pour NS5A, et les connaissances structurales restent limitées. Ainsi, nous avons caractérisé l'état intrinsèquement désordonné des domaines D2 et D3 de NS5A en décrivant leurs espaces conformationnels et leurs potentialités de repliement en combinant différentes méthodes biophysiques. Nous avons aussi mis en évidence la variabilité structurale du dom

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Rickard, Jenaya. "Development of FRET-based assays to characterize the HCV NS5a homodimerization and its interaction with RNA." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119687.

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Hepatitis C (HCV) non-structural protein 5a (NS5a) is an RNA binding protein that plays an essential role in viral replication and assembly. NS5a domain I (NS5a-DI) forms a dimer and has been crystalized in two different conformations. The specific amino acid residues involved in dimerization and RNA binding are currently unknown, however, the dimeric form of NS5a-DI is proposed to be the active RNA binding conformation. There are currently no cell-free assays to study the NS5a dimerization and only a limited number of RNA-binding assays. We non-specifically labeled NS5a-DI with fluorescent Cy

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REFOLO, GIULIA. "Characterization of HCV NS5A cellular interactors: role of MOB1B and LRPPRC in viral replication and assembly." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2012. http://hdl.handle.net/2108/202215.

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Hepatitis C virus (HCV) is a hepatotropic positive-strand RNA virus which belongs to the Flaviviridae family. With almost 170 million people infected worldwide, HCV is a leading cause of chronic hepatitis, liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC) (Poynard, T., et al., 2003). Major improvements in patient treatment were achieved by the approval of the first direct acting antivirals (DAAs) in 2011 (Welsch, C., et al., 2012). Nonetheless, HCV variants resistant to DAAs may arise during treatment as well as a heavy burden of side effects, thus affecting therapy outcome. Cellul

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Zhang, Zhihan. "NSEA: n-Node Subnetwork Enumeration Algorithm Identifies Lower Grade Glioma Subtypes with Altered Subnetworks and Distinct Prognostics." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case148595901371196.

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Shu, Jonathan Lee Yee. "Investigation into the impacts of migration to emergent NSA Suite B encryption standards." Thesis, Monterey, California. Naval Postgraduate School, 2009. http://hdl.handle.net/10945/4675.

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Approved for public release, distribution unlimited<br>As information sharing becomes increasingly necessary for mission accomplishment within the Department of Defense, the rules for protecting information have tightened. The sustained and rapid advancement of information technology in the 21st century dictates the adoption of a flexible and adaptable cryptographic strategy for protecting national security information. RSA techniques, while formidable, have begun to present vulnerabilities to the raw computing power that is commercially available today. This thesis is a comprehensive characte

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Venema, Jacob Paul Shu Jonathan Lee Yee. "Investigation into the impacts of migration to emergent NSA Suite B encryption standards." Monterey, Calif. : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Jun/09Jun%5FVenema.pdf.

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Thesis (M.S. in Systems Technology (Command, Control & Communications (C3)))--Naval Postgraduate School, June 2009 by Jacob P. Venema. Thesis (M.S. in Software Engineering)--Naval Postgraduate School, June 2009 by Jonahan Lee Yee Shu.<br>Thesis Advisor(s): Fulp, John D. ; Riehle, Richard. "June 2009." Description based on title screen as viewed on July 14, 2009. Author(s) subject terms: elliptical curve cryptography, ECC, Rivest Shamir and Adleman, RSA, NSA Suite B, encryption, digital signature, key agreement, ECC migration, risk mitigation. Includes bibliographical references (p. 95-98). Al

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