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Journal articles on the topic 'Nube informatica'
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Flantrmsky-Cárdenas, Henry Humberto. "Cloud Computing and the Change in the Universe of Information Science." Pensamiento y Cultura 15, no. 1 (2012): 88–93. http://dx.doi.org/10.5294/pecu.2012.15.1.7.
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Planas i Silva, Carlota. "Cookie cloudy, cooked Google: ¡Al loro, bibliotecas en la nube!" Ibersid: revista de sistemas de información y documentación 6 (August 21, 2012): 31–43. http://dx.doi.org/10.54886/ibersid.v6i.3967.
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Las Bibliotecas tienen que vigilar cuando hagan el cambio a la Nube. La Nube es promocionada como un servicio gratuito. El concepto de gratuidad es irresistible a cualquier decisión de un consumidor. Esta es la estrategia de Google, también seguida por Facebook, Yahoo, Apple, entre otros. Sin embargo, ¿cuál es el coste?. Contenidos y privacidad son la moneda de cambio en la Nube, la cual, a su vez, está promocionada por instituciones públicas sólo como el remedio para superar la crisis. No importa si el reme-dio causa daños colaterales, como la vulneración de privacidad, contenidos o afectación del mercado de la libre competencia, con sus respectivas leyes. Las Bibliotecas tienen que estar alerta ante la Nube, pues tienen un importante legado para preservar, no sola-mente en términos de contenidos sino también de privacidad y valores. Si hay alguna curación, a la actual falta de legislación y jurisprudencia afín, debe ser a través de soluciones legales internacionales. Por desgracia, no parece que éste sea el pronóstico inmediato para hacer frente a la Nube. Google es realmente inmenso, en un gran logos, “dios”, que sabe cada detalles de cualquier ser humano expuesto digitalmente en línea.
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Lara-Navarra, Pablo, and David Maniega-Legarda. "Conocimiento en la Nube: Evolución de las Intranets." El Profesional de la Informacion 20, no. 2 (2011): 175–82. http://dx.doi.org/10.3145/epi.2011.mar.07.
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Brown, Bruce Alan, and Andrea Sommer-Mathis. "Tu felix Austria nube: Hochzeitsfeste der Habsburger im 18. Jahrhundert." Notes 53, no. 2 (1996): 463. http://dx.doi.org/10.2307/900130.
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Corral Velázquez, Gabriel A. "Cartografía discursiva del proceso electoral 2024 en México: un análisis desde X (Twitter)." ComHumanitas: revista científica de comunicación 16, no. 1 (2025): 150–66. https://doi.org/10.31207/rch.v16i1.543.
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Se realiza un análisis de las dinámicas discursivas generadas en X (Twitter) durante la campaña presidencial mexicana de 2024. A través de una metodología mixta basada en, análisis de redes y lectura de discurso, se examinó un corpus de más de 500 tuits publicados entre marzo y mayo de 2024, seleccionados mediante muestreo temático. El estudio identifica los principales hashtags empleados, las cuentas con mayor visibilidad, los momentos de mayor intensidad en la conversación digital y los núcleos semánticos más recurrentes. Los resultados muestran que Twitter operó como un espacio de confrontación simbólica donde convergen actores institucionales, usuarios comunes y medios de comunicación en torno a disputas por la legitimidad del proceso electoral, las encuestas, los debates y la figura del presidente saliente. Se detectaron tres picos de interacción que coinciden con eventos coyunturales claves: el primer debate presidencial, la filtración de encuestas internas y la marcha en defensa del INE. La nube de palabras evidencia una tensión entre narrativas institucionales y contrahegemónicas, así como una apropiación crítica del discurso mediático. Se concluye que los lenguajes digitales no solo vehiculan contenido político, sino que modelan formas de participación, interpretación y construcción de sentido en contextos de alta densidad informativa.
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Evenepoel, Charlotte, Egbert Clevers, Lise Deroover, Wendy Van Loo, Christophe Matthys, and Kristin Verbeke. "Accuracy of Nutrient Calculations Using the Consumer-Focused Online App MyFitnessPal: Validation Study." Journal of Medical Internet Research 22, no. 10 (2020): e18237. http://dx.doi.org/10.2196/18237.
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Background Digital food registration via online platforms that are coupled to large food databases obviates the need for manual processing of dietary data. The reliability of such platforms depends on the quality of the associated food database. Objective In this study, we validate the database of MyFitnessPal versus the Belgian food composition database, Nubel. Methods After carefully given instructions, 50 participants used MyFitnessPal to each complete a 4-day dietary record 2 times (T1 and T2), with 1 month in between T1 and T2. Nutrient intake values were calculated either manually, using the food composition database Nubel, or automatically, using the database coupled to MyFitnessPal. First, nutrient values from T1 were used as a training set to develop an algorithm that defined upper limit values for energy intake, carbohydrates, fat, protein, fiber, sugar, cholesterol, and sodium. These limits were applied to the MyFitnessPal dataset extracted at T2 to remove extremely high and likely erroneous values. Original and cleaned T2 values were correlated with the Nubel calculated values. Bias was estimated using Bland-Altman plots. Finally, we simulated the impact of using MyFitnessPal for nutrient analysis instead of Nubel on the power of a study design that correlates nutrient intake to a chosen outcome variable. Results Per food portion, the following upper limits were defined: 1500 kilocalories for total energy intake, 95 grams (g) for carbohydrates, 92 g for fat, 52 g for protein, 22 g for fiber, 70 g for sugar, 600 mg for cholesterol, and 3600 mg for sodium. Cleaning the dataset extracted at T2 resulted in a 2.8% rejection. Cleaned MyFitnessPal values demonstrated strong correlations with Nubel for energy intake (r=0.96), carbohydrates (r=0.90), fat (r=0.90), protein (r=0.90), fiber (r=0.80), and sugar (r=0.79), but weak correlations for cholesterol (ρ=0.51) and sodium (ρ=0.53); all P values were ≤.001. No bias was found between both methods, except for a fixed bias for fiber and a proportional bias for cholesterol. A 5-10% power loss should be taken into account when correlating energy intake and macronutrients obtained with MyFitnessPal to an outcome variable, compared to Nubel. Conclusions Dietary analysis with MyFitnessPal is accurate and efficient for total energy intake, macronutrients, sugar, and fiber, but not for cholesterol and sodium.
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Rodríguez Malmierca, Maria José. "Computación en la Nube y Software Abierto para la Escuela Rural Europea." Pixel-Bit, Revista de Medios y Educación, no. 64 (2022): 105–37. http://dx.doi.org/10.12795/pixelbit.93937.
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La tecnología de la computación en la nube ofrece grandes posibilidades en contextos con dificultades de infraestructura y pueden proporcionar un puente para ayudar a superar la brecha existente en las escuelas rurales europeas por su falta de recursos, aislamiento, sus limitaciones en las infraestructuras y de soporte tecnológico. El propósito de este estudio fue diseñar, implementar y evaluar un entorno para la enseñanza flexible y la colaboración en centros educativos rurales de Europa basado en la tecnología de computación en la nube y se llevó a cabo en el marco de un proyecto de investigación europeo (RuralSchoolCloud). Para ello se realizó una investigación basada en diseño (IBD) en 14 escuelas rurales de cinco países europeos (Dinamarca, España, Gran Bretaña, Italia, Grecia). La muestra objeto de estudio queda conformada por un total de 560 estudiantes y 72 docentes de educación Infantil, Primaria y Secundaria obligatoria que contestaron el "Cuestionario de análisis del entorno educativo RSC de computación en la nube". En términos generales, los resultados muestran que el entorno educativo RSC demostró ser una herramienta potente para proporcionar un recurso educativo técnico funcional y utilizable para las escuelas rurales de la UE, permitiendo flexibilidad temporal y espacial en las interacciones de profesores y estudiantes, y proporcionando una herramienta adaptada a las diferentes características, necesidades e intereses de las escuelas rurales.
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Delgado-Gómez, Alejandro. "Archivar en la nube: reglas de producción del documento contemporáneo. Parte I: Indicadores tecnológicos." El Profesional de la Informacion 20, no. 4 (2011): 406–16. http://dx.doi.org/10.3145/epi.2011.jul.07.
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Delgado-Gómez, Alejandro. "Archivar en la nube: Reglas de producción del documento contemporáneo. Parte II: Indicadores sociales." El Profesional de la Informacion 21, no. 5 (2012): 475–81. http://dx.doi.org/10.3145/epi.2012.sep.05.
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Valentín Ruiz, Francisco José, and Robert Torre-Marín Amorós. "Aplicación de tecnología cloud computing en bibliotecas y centros de documentación." Ibersid: revista de sistemas de información y documentación 7 (September 21, 2013): 41–47. http://dx.doi.org/10.54886/ibersid.v7i0.4062.
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La evolución de la automatización de bibliotecas establecida en cuatro periodos —pre-MARC, después de OCLC, después de Internet y socialización de Internet— permite explicar la aparición del cloud computing aplicado a bibliotecas y centros de documentación como un servicio alternativo a los tradicionales sistemas integrados de gestión de bibliotecas (SIGB). En base a esta evolución, se analizan las ventajas e inconvenientes de los servicios en la nube. Estas características se ponen en relación con dos de los servicios de OCLC: WorldShare para bibliotecas y CONTENTdm de gestión de contenidos digitales. De estos dos servicios se ofrecen ejemplos de uso.
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Tolosa-Cuadrado, Cristhian Leonardo, and Juan Sebastián González-Sanabria. "Amazon Web Services: alternativa para el almacenamiento de información-Amazon Web Services: an alternative for storing information." Revista científica 2, no. 19 (2014): 134. http://dx.doi.org/10.14483/23448350.6500.
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Este artículo reseñó la computación en la nube y de algunos de sus servicios de almacenamiento en sistemas gestores de bases de datos relacionales y no relacionales ofrecidos por Amazon bajo el modelo de la infraestructura como servicio (IaaS ‘infrastructure as a service’). Se realiza una comparación entre los sistemas tradicionales de almacenamiento en las organizaciones y la infraestructura como servicio, para dar a conocer las ventajas y las desventajas de la adopción de nuevas tecnologías en el ámbito personal, organizacional y académico en cuanto al almacenamiento y procesamiento de la información. Además, se describen los diferentes servicios de bases de datos ofrecidos por Amazon Web Services, los cuales ofrecen el servicio de almacenamiento según las necesidades y las tecnologías que el usuario necesite.
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Cavadas Gormaz, María José, and María del Mar López Talavera. "Capítulo 9. Ética periodística, contra la guerra de guerrillas de las fake news." Espejo de Monografías de Comunicación Social, no. 13 (March 28, 2023): 175–89. http://dx.doi.org/10.52495/c9.emcs.13.p99.
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La pandemia producida por la Covid 19 alertó sobre el riesgo añadido de padecer un bombardeo de noticias falsas que dificultarían la aplicación de medidas sanitarias para evitar la extensión de la epidemia y soluciones para superarla. La nube tóxica se filtró a través de las redes sociales, especialmente a través de WhatsApp, donde no se aplicaron cortafuegos ni métodos de control que taponaran la hemorragia informativa. La situación se ha visto agravada por el hecho de que esta explosión de falsedades y distorsiones sobre un asunto tan vital como la salud coincide con un momento de pérdida masiva de confianza en los medios de comunicación (Newman et al., 2020).Las prospecciones de futuro indican que la tendencia a la proliferación de lo que se ha dado en llamar “guerra híbrida” (Korybko, 2020) no tiene perspectivas de remitir, sino que irá en aumento dado el carácter viral de las fakes. Desde este artículo se ha revisado la literatura científica publicada durante el primer año de la pandemia con el fin de diseñar el correcto tratamiento deontológico que evite futuras convulsiones. La receta que aquí se propone, como muro de contención a la marea infotóxica, consiste en reforzar la aplicación de los principios éticos en el periodismo informativo. El presente trabajo propone acciones preventivas y asume que la Ética Profesional del periodista se enfrenta a una guerra de guerrillas frente a un entorno que favorece la expansión de la mentira. Palabras clave: ética, desinformación, guerra híbrida, neutralizar las fake news, redes sociales.
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Viloria, Rebeca, and Giovanni Bracho. "Prototipo de un monitor cardiaco implementando IOT." TECHNO REVIEW. International Technology, Science and Society Review /Revista Internacional de Tecnología, Ciencia y Sociedad 11, Monográfico (2022): 1–11. http://dx.doi.org/10.37467/revtechno.v11.4406.
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El objetivo del estudio consiste en desarrollar un prototipo de monitoreo cardiaco ambulatorio implementando IoT. En el presente trabajo se muestra el desarrollo de un dispositivo capaz de estudiar la frecuencia cardiaca utilizando tecnología IoT.El dispositivo desarrollado cuenta con características como amplificar, filtrar y acondicionar la señal cardiaca gracias a su arquitectura y los tres electrodos conectados en puntos específicos del cuerpo humano. Al adquirir estos datos, se realiza el envío a través de un módulo de desarrollo programable el cual se conecta a internet vía WiFi y envía la información obtenida a un servidor web en la nube.
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Gairín, Por Josep Manuel Rodríguez i. "PHP-Nuke: software de código abierto en la gestión de contenidos web." El Profesional de la Informacion 13, no. 6 (2004): 458–66. http://dx.doi.org/10.3145/epi.2004.nov.06.
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ITO, Mamoru. "Inspection of Information about the 3.11 Nuke Crisis: To Organize Informed Consent Society." TRENDS IN THE SCIENCES 18, no. 1 (2013): 1_8–1_14. http://dx.doi.org/10.5363/tits.18.1_8.
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Morales, Fernando, Lluis Mas, and Ruben Tous. "Modelo en red de los contenidos mediáticos en la era de los dispositivos inteligentes." Ibersid: revista de sistemas de información y documentación 10, no. 2 (2016): 69–78. http://dx.doi.org/10.54886/ibersid.v10i2.4362.
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Los cambios en las tecnologías de la información en las últimas décadas, representados por la democratización de Internet y la disponibilidad de las computadoras portátiles y dispositivos inteligentes están asociados con nuevos negocios y modelos comunicativos. La capacidad de los actuales teléfonos inteligentes facilita el procesamiento bidireccional y dinámico de grandes cantidades de contenidos. Los usuarios se agrupan en comunidades virtuales y se convierten en consumidores y productores: prosumidores. Estos contenidos se encuentran en la nube, en los medios de comunicación (plataformas), y se propagan rápidamente a través de la red. En este artículo se analiza la evolución de estos flujos de mensajes en el marco de las teorías que rodean el contenido generado por el usuario y la convergencia de medios. Se analiza también la naturaleza cíclica de la secuencia de datos, la evolución de los usuarios y la dependencia tecnológica para desarrollar y distribuir nuevos productos discursivos Se propone finalmente un modelo de flujos basado en algoritmos determinados por las preferencias personales de los usuarios.
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Razzouk, Nabil, and Victoria Seitz. "Nude Recreation in the U. S.: An Empirical Investigation." Journal of Hospitality & Leisure Marketing 10, no. 3-4 (2003): 145–57. http://dx.doi.org/10.1300/j150v10n03_09.
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Palos-Sanchez, Pedro R., Rafael Robina Ramírez, and Luis Manuel Cerdá Suárez. "Ética de la reputación online, marca personal y privacidad en el cloud computing: protección de los usuarios frente al derecho al olvido." Biblios: Journal of Librarianship and Information Science, no. 71 (July 2, 2018): 17–31. http://dx.doi.org/10.5195/biblios.2018.428.
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Objetivo. Este artículo tiene como principal objetivo, analizar la situación actual y las previsiones futuras que puede tener la falta de privacidad en la nube o cloud computing. El borrado de los datos personales que indexa el buscador Google, retirar una foto de Facebook, eliminar un link de una noticia desafortunada o borrar el pasado puede ser una tarea que se nos antoje imposible. Aquellas personas afectadas por situaciones así, reclaman la aplicación del “derecho al olvido” basado en motivaciones plausibles.Método. Este estudio ha contrastado las opiniones de afectados, abogados y expertos en reputación online y comunicación de marca personal.Resultados. Los resultados demuestran la desproteción legal y la responsabilidad de los buscadores en la vulneración ética y, en algunos casos, legal de estos derechos.Conclusiones. La privacidad va camino de convertirse en el principal quebradero de cabeza para los buscadores. Esta conclusión, no sólo proviene de las polémicas suscitadas, sino por las numerosas denuncias que señalan ahora a la herramienta y no sólo al origen de la información. Normalmente, la herramienta es el buscador, que pone al alcance general datos que los interesados preferirían suprimir o que permanezcan en el olvido.
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Hu, Rong, Qianqian Zeng, Xiaoling Su, Wenxia Feng, and Hong Xiang. "The Correlation between Targeted Contrast-Enhanced Ultrasound Imaging and Tumor Neovascularization of Ovarian Cancer Xenografts in Nude Mice." Journal of Healthcare Engineering 2021 (March 17, 2021): 1–13. http://dx.doi.org/10.1155/2021/5553649.
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In order to explore the correlation between targeted contrast-enhanced ultrasound imaging and tumor neovascularization of ovarian cancer xenografts in nude mice, a total of 49 nude mice were selected and randomly divided into 1-week group, 2-week group, 3-week group, 4-week group, 5-week group, 6-week group, and 7-week group according to their ovarian cancer xenografts’ growth time, with 7 ovarian cancer xenografts in each group. After preparing antibody-carrying targeted contrast agent, each group of xenografts performed normal and targeted contrast ultrasound examinations to obtain peak intensity, time to peak, and other imaging parameters; then, those ovarian cancer xenografts were sacrificed for pathological analysis: the neovascular density and antibody expression of the cancer xenografts at different stages were observed and counted, and the correlation between targeted contrast-enhanced ultrasound parameters and tumor neovascular densities of the ovarian cancer xenografts was analyzed. The results show that the peak intensities of targeted contrast ultrasound imaging are greater than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); the time to peak of targeted contrast ultrasound imaging is shorter than that of ordinary ultrasound imaging in the 2-, 3-, 4-, and 5-week groups with statistically significant differences ( P < 0.05 ); there is a positive correlation between the peak intensities of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week group (r2 = 0.645, r3 = 0.668, and r4 = 0.693, P < 0.05 ); there is a negative correlation between the time to peak of targeted contrast ultrasound imaging and tumor neovascular densities of the ovarian cancer xenografts in the 2-, 3-, and 4-week groups (r2 = −0.669, r3 = −0.692, and r4 = −0.704, P < 0.05 ). Therefore, the targeted contrast-enhanced ultrasound imaging parameters have a certain correlation with tumor neovascular density of ovarian cancer xenografts in nude mice and this correlation is more significant in the early stage of ovarian cancer; hence, targeted contrast-enhanced ultrasound imaging may provide a new method, new idea, and new basis for the diagnosis of early ovarian cancer.
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Sarfraz, Muhammad, and Mohammed Ali Siddiqui. "Development of a multi-resolution framework for NUBS." Information Sciences 163, no. 4 (2004): 239–51. http://dx.doi.org/10.1016/j.ins.2003.06.010.
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English, Erin. "Cache of nude images found at nuclear weapons lab." Network Security 1994, no. 7 (1994): 2–3. http://dx.doi.org/10.1016/1353-4858(94)90003-5.
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Marwick, Alice E. "Scandal or sex crime? Gendered privacy and the celebrity nude photo leaks." Ethics and Information Technology 19, no. 3 (2017): 177–91. http://dx.doi.org/10.1007/s10676-017-9431-7.
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Hoa, Ta Quynh. "Study on the mechanism of urban planning information exchange to enhance the community participation in urban detailed planning in Vietnam – towards sustainable development." Journal of Science and Technology in Civil Engineering (STCE) - HUCE 16, no. 1 (2022): 42–56. http://dx.doi.org/10.31814/stce.huce(nuce)2022-16(1)-04.
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This paper explores the extent of the current mechanism to access urban spatial planning information of community in urban detailed planning projects (UDPPs), the constraints on urban planning information accessibility in Vietnam context to challenge the community participation for sustainable development. The research is based on an analysis of the planning information sharing content found in four UDPPs in Vietnam and interviews with 20 key informants. The research identified that the urban spatial planning information for the community is limited and difficult to access, and the planning information exchange process is one-way flow, authority-controlled and non-transparent. Besides, the lack of human resources and technological application provide a challenging context for involving the community in UDPPs. The paper concludes by proposing several recommendations for improving the urban planning information exchange process and technological tools that should be applied to foster community participation in Vietnam's urban context, towards sustainable development.
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Duluc, I., J. N. Freund, C. Leberquier, and M. Kedinger. "Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development." Journal of Cell Biology 126, no. 1 (1994): 211–21. http://dx.doi.org/10.1083/jcb.126.1.211.
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In rodents, the intestinal tract progressively acquires a functional regionalization during postnatal development. Using lactase-phlorizin hydrolase as a marker, we have analyzed in a xenograft model the ontogenic potencies of fetal rat intestinal segments taken prior to endoderm cytodifferentiation. Segments from the presumptive proximal jejunum and distal ileum grafted in nude mice developed correct spatial and temporal patterns of lactase protein and mRNA expression, which reproduced the normal pre- and post-weaning conditions. Segments from the fetal colon showed a faint lactase immunostaining 8-10 d after transplantation in chick embryos but not in mice; it is consistent with the transient expression of this enzyme in the colon of rat neonates. Heterotopic cross-associations comprising endoderm and mesenchyme from the presumptive proximal jejunum and distal ileum developed as xenografts in nude mice, and they exhibited lactase mRNA and protein expression patterns that were typical of the origin of the endodermal moiety. Endoderm from the distal ileum also expressed a normal lactase pattern when it was associated to fetal skin fibroblasts, while the fibroblasts differentiated into muscle layers containing alpha-smooth-muscle actin. Noteworthy, associations comprising colon endoderm and small intestinal mesenchyme showed a typical small intestinal morphology and expressed the digestive enzyme sucrase-isomaltase normally absent in the colon. However, in heterologous associations comprising lung or stomach endoderm and small intestinal mesenchyme, the epithelial compartment expressed markers in accordance to their tissue of origin but neither intestinal lactase nor sucrase-isomaltase. A thick intestinal muscle coat in which cells expressed alpha-smooth-muscle actin surrounded the grafts. The results demonstrate that: (a) the temporal and positional information needed for intestinal ontogeny up to the post-weaning stage results from an intrinsic program that is fixed in mammalian fetuses prior to endoderm cytodifferentiation; (b) this temporal and positional information is primarily carried by the endodermal moiety which is also able to change the fate of heterologous mesodermal cells to form intestinal mesenchyme; and (c) the small intestinal mesenchyme in turn may deliver instructive information as shown in association with colonic endoderm; yet this effect is not obvious with nonintestinal endoderms.
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Yang, Dongdong, Ping Gao, Chao Tian, and Yang Sheng. "Gompertz tracking of the growth trajectories of the human-liver-cancer xenograft-tumors in nude mice." Computer Methods and Programs in Biomedicine 191 (July 2020): 105412. http://dx.doi.org/10.1016/j.cmpb.2020.105412.
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Saldívar-González, Fernanda I., Marilia Valli, Adriano D. Andricopulo, Vanderlan da Silva Bolzani, and José L. Medina-Franco. "Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization." Journal of Chemical Information and Modeling 59, no. 1 (2018): 74–85. http://dx.doi.org/10.1021/acs.jcim.8b00619.
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Tomić, Damir. "Integration of information and communication technology (ICT) in preschool care and education." Odgojno-obrazovne teme 6, no. 1 (2023): 27–52. http://dx.doi.org/10.53577/oot.6.1.2.
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Integracija informacijske i komunikacijske tehnologije (IKT) u predškolski odgoj predmet je interesa istraživača i odgajatelja. Kako bi se dobio pregled trenutnog stanja istraživanja u ovom području, proveden je Sustavni pregled literature (SLR) koji se temeljio na tri istraživačka pitanja u 155 jedinstvenih publikacija: (1) Koje su dominantne istraživačke paradigme, vrste studija i metode korištene u relevantnom istraživanju integracije IKT-a u predškolski odgoj i obrazovanje?, (2) Koji su ključni nalazi primjene IKT-a u predškolskom odgoju i obrazovanju?, (3) Koje su preporuke za buduća istraživanja integracije IKT-a u predškolski odgoj i obrazovanje?. SLR je proveden u tri faze: odabir članka, sažeti pregled i cjeloviti pregled članka. Na temelju procjena istraživača i značajnih nalaza, autor je kritički pregledao sve provjerene članke i odabrao 16 relevantnih publikacija za daljnju analizu, isključujući publikacije s najnižom ocjenom relevantnosti ili lošom metodologijom. Nalazi SLR-a nude dragocjene uvide odgajateljima i kreatorima politika za donošenje odluka o integraciji IKT-a u predškolsko obrazovanje. Međutim, rezultati su također pokazali da učinkovita integracija IKT-a u predškolsko obrazovanje zahtijeva obuku i podršku odgajatelja, odabir odgovarajućih IKT alata i razvoj vještina digitalne pismenosti kod male djece.
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Deng, Yang, Jiapeng Li, Yingjie Zhang, et al. "NUF2 Promotes Breast Cancer Development as a New Tumor Stem Cell Indicator." International Journal of Molecular Sciences 24, no. 4 (2023): 4226. http://dx.doi.org/10.3390/ijms24044226.
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Multiple new subtypes of breast cancer (BRCA) are identified in women each year, rendering BRCA the most common and rapidly expanding form of cancer in females globally. NUF2 has been identified as a prognostic factor in various human cancers, regulating cell apoptosis and proliferation. However, its role in BRCA prognosis has not been clarified. This study explored the role of NUF2 in breast cancer development and prognosis using informatic analysis combined with in vivo intracellular studies. Through the online website TIMER, we evaluated the transcription profile of NUF2 across a variety of different cancer types and found that NUF2 mRNA was highly expressed in BRCA patients. Its transcription level was found to be related to the subtype, pathological stage, and prognosis of BRCA. The R program analysis showed a correlation of NUF2 with cell proliferation and tumor stemness in the BRCA patient samples. Subsequently, the association between the NUF2 expression level and immune cell infiltration was analyzed using the XIANTAO and TIMER tools. The results revealed that NUF2 expression was correlated with the responses of multiple immune cells. Furthermore, we observed the effect of NUF2 expression on tumor stemness in BRCA cell lines in vivo. The experimental results illuminated that the overexpression of NUF2 statistically upregulated the proliferation and tumor stemness ability of the BRCA cell lines MCF-7 and Hs-578T. Meanwhile, the knockdown of NUF2 inhibited the abilities of both cell lines, a finding which was verified by analyzing the subcutaneous tumorigenic ability in nude mice. In summary, this study suggests that NUF2 may play a key role in the development and progression of BRCA by affecting tumor stemness. As a stemness indicator, it has the potential to be one of the markers for the diagnosis of BRCA.
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Hasanović, Šejla. "TELEMATSKI SISTEMI U VOZILIMA." NIR, no. 14 (December 1, 2018): 127. https://doi.org/10.59417/nir.2018.14.127.
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Kada je riječ o telematici u drumskom transportnom sistemu zapravo se radi o inteligentnoj kombinaciji izmeĎu upravljačkih centrala i automobilskih kompjutera, koji treba da se stara za tečno odvijanje saobraćaja i ujedno da ga učini sigurnijim i ekološki čistijim. Telematika je pojam koji moţe da ima različite definicije u zavisnosti od trţišta ili sektora u kome se koristi, pa je tako telematika, takoĎe, pojam koji podrazumijeva korišćenje kompjutera za kontrolu i nadziranje daljinskih ureĎaja ili sistema. U drumskom transportu pod pojmom daljinski ureĎaji koji se kontrolišu i nadziru podrazumijevaju se solo, vučna i priključna vozila. Po opremljenosti s telematskom opremom trenutno prednjače SAD, zatim ih prati zapadna Evropa, dok su telematski najmanje opremljena vozila koja se sreću na japanskom trţištu i ako ovo trţište predstavlja uzor na području mobilnih komunikacija i zabavne elektronike. U mnogim evropskim zemljama se trenutno radi na razvoju nacionalnih telematskih sistema. Telematika je tehnologija koja je sastavljena iz informatičke i komunikacione tehnologije, koja tehnološki objedinjuje područja telekomunikacija i informatike. Telematski sistemi u vozilima se mogu iskoristiti u različite svrhe, kao što su prikupljanje podataka o voţnjama, upravljanje prevoznim procesima, praćenje lokacije vozila, pronalaţenje ukradenih vozila, pruţanje usluge davanja informacija vozačima o putanjama kretanja vozila i sl. Na trţištu postoji veliki broj proizvoĎača telematskih sistema i drugih kompanija koje pruţaju usluge ovog tipa, te se usljed toga pojavljuju proizvodi različitih mogućnosti i cijena. Upravo zbog toga je vaţno da se prilikom izbora dobavljača ove opreme razmotri njihov proizvod u cjelini i da se tom prilikom odluke ne donose na osnovu atraktivnosti opreme u vozilima ili spoljašnjeg izgleda, nego je potrebno prilikom izbora komponenti i vrste telematskog sistema razmotriti sve mogućnosti koje oni nude.
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Healthcare Engineering, Journal of. "Retracted: The Correlation between Targeted Contrast-Enhanced Ultrasound Imaging and Tumor Neovascularization of Ovarian Cancer Xenografts in Nude Mice." Journal of Healthcare Engineering 2023 (May 24, 2023): 1. http://dx.doi.org/10.1155/2023/9872503.
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Frick, A., and J. A. Groenewald. "THE NEED FOR AGRICULTURAL INFORMATION IN THE NEW SOUTH AFRICA / DIE BEHOEFTE AAN LANDBOU-INLIGTING IN DIE NUWE SUID-AFRIKA." Agrekon 38, no. 2 (1999): 241–54. http://dx.doi.org/10.1080/03031853.1999.9523552.
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Silva, Marcio Ponciano da, and Angel Freddy Godoy Viera. "Descoberta de conhecimento com uso de técnicas de mineração de textos aplicadas em documentos textuais da investigação policial brasileira." Investigación Bibliotecológica: archivonomía, bibliotecología e información 35, no. 88 (2021): 161. http://dx.doi.org/10.22201/iibi.24488321xe.2021.88.58389.
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El objetivo de este estudio es analizar cómo las técnicas de minería de textos aplicadas a documentos textuales de la investigación policial brasileña pueden promover el descubrimiento de conocimiento. La investigación recopiló documentos de la investigación policial y los sometió al proceso de minería de textos. El estudio utilizó las técnicas de plegado de casos, tokenización, palabras vacías personalizadas, bolsa de palabras y TF-IDF para extraer los resultados en ngramas. Los resultados se presentaron con nubes de palabras. En la investigación, se utilizaron k-medias para agrupar los conjuntos de trigramas, identificando en cada grupo los términos más representativos de los grupos. El uso de técnicas de minería de textos en estos documentos tenía como objetivo extraer conocimientos no triviales. Las técnicas de minería de texto, o descubrimiento de conocimiento en una base de datos textual, tienen el propósito de descubrir patrones inobservables cuando se analizan mediante manipulación humana de grandes volúmenes de documentos. Los resultados encontrados favorecieron el descubrimiento de conocimientos en la identificación de entidades y conexiones, así como categorías temáticas de la investigación.
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Chopra, Akanksha Bansal, and Veer Sain Dixit. "An adaptive RNN algorithm to detect shilling attacks for online products in hybrid recommender system." Journal of Intelligent Systems 31, no. 1 (2022): 1133–49. http://dx.doi.org/10.1515/jisys-2022-1023.
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Abstract Recommender system (RS) depends on the thoughts of numerous users to predict the favourites of potential consumers. RS is vulnerable to malicious information. Unsuitable products can be offered to the user by injecting a few unscrupulous “shilling” profiles like push and nuke attacks into the RS. Injection of these attacks results in the wrong recommendation for a product. The aim of this research is to develop a framework that can be widely utilized to make excellent recommendations for sales growth. This study uses the methodology that presents an enhanced clustering algorithm named as modified density peak clustering algorithm on the consumer review dataset to ensure a well-formed cluster. An improved recurrent neural network algorithm is proposed to detect these attacks in hybrid RS, which uses the content-based RS and collaborative filtering RS. The results are compared with other state of the art algorithms. The proposed method is more suitable for E-commerce applications where the number of customers and products grows rapidly.
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Bradshaw, Susan, and Pierre Boulez. "Pli selon pli, nr. 4: Improvisation III sur Mallarme-"a la nue accablante tu" pour soprano et orchestre." Notes 48, no. 1 (1991): 294. http://dx.doi.org/10.2307/941840.
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Peñaloza Báez, Marcela Juliana. "Big data y analítica del aprendizaje en aplicaciones de salud y educación médica." Investigación en Educación Médica 7, no. 25 (2018): 61–66. http://dx.doi.org/10.1016/j.riem.2017.11.003.
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Big data y la analítica del aprendizaje son herramientas que permiten aprovechar enormes cantidades de datos que hoy existen en formato digital, y que se generan durante la prestación de servicios de salud y cuando se incorporan plataformas digitales al proceso de enseñanza-aprendizaje en la formación de médicos. El objetivo es diseñar proyectos que exploten las ventajas de las capacidades técnicas actuales para el procesamiento automatizado de datos en grandes volúmenes y distintos formatos, para buscar su entendimiento y mejorar la toma de decisiones. Las asociaciones, los patrones y las tendencias que pueden emerger del análisis de datos generados en la educación médica pueden facilitar el seguimiento e incluso modelar la conducta de los estudiantes, y perfilar su desempeño. Con Big data y la analítica del aprendizaje es posible transformar grandes cantidades de datos en información de muy alta calidad. Lo anterior es un área que puede ser aprovechada por el educador médico, quien conoce la información que tiene disponible y la que puede obtener mediante alianzas y acuerdos legales, a partir de un problema que se requiera resolver; se necesita apoyo de expertos técnicos pero, en todo momento, el rumbo del proyecto le corresponde a quien ha definido el problema, pues es quien conoce el marco de referencia y las posibles acciones a tomar con los hallazgos y las ideas que surjan. Ciertamente se requiere infraestructura, pero con las posibilidades para el trabajo en la nube, y los recursos disponibles en las instituciones médicas y de educación superior, se puede partir de un primer nivel de hardware y software, y escalar a plataformas más sofisticadas cuando la combinación de hallazgos en los datos y de los volúmenes a procesar lo justifique. Sin duda, Big data y analítica del aprendizaje son herramientas en las que el educador médico debe poner atención.
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Zhu, Bohui, Yiyuan Sun, Xiaoqing Wei, et al. "Dendritic Cell Vaccine Loaded with MG-7 Antigen Induces Cytotoxic T Lymphocyte Responses against Gastric Cancer." Journal of Healthcare Engineering 2022 (April 18, 2022): 1–7. http://dx.doi.org/10.1155/2022/1964081.
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Dendritic cells (DCs) are antigen-presenting cells that can activate T cells and initiate a primary immune response. Personalized DC vaccines have demonstrated a modest antitumor potential in some clinical pilot studies. However, those vaccines are difficult to manufacture and have a limited antitumor response. In this study, a lentiviral vector-programmed DC vaccine with high antitumor responses is developed. By transfecting with a lentiviral vector, the DC vaccine is loaded with MG-7 antigen (MG-7Ag). Three representative gastric cancer cell lines, such as KATO-3, MKN45, and SNU16, are used to estimate the in vitro cytotoxic effect of the MG-7Ag DC vaccine. Furthermore, we examine the in vivo antitumor efficacy of specific cytotoxic T lymphocytes (CTLs) induced by the MG-7Ag DC vaccine in patient-derived xenograft (PDX) mice models. The current data demonstrate that the MG-7Ag DC vaccine induced a potent CTL activity. Those CTLs have a significant cytotoxic effect on both KATO-3 and MKN45 with high level of MG-7 expression. In addition, MG-7Ag DC vaccine-mediated CTLs significantly inhibit the growth of tumor xenografts in nude mice. The MG-7Ag DC vaccine activate the cytotoxic effect of lymphocytes and can be employed as a vaccine in gastric cancer immunotherapy.
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Semenski, Vikica, Jagoda Ille, and Višnja Cej. "Digitalno, virtualno, online – u fokusu." Vjesnik bibliotekara Hrvatske 64, no. 1 (2021): 137. http://dx.doi.org/10.30754/vbh.64.1.855.
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Cilj. Knjižnice grada Zagreba korisnicima nude raznovrsne mrežne usluge i sadr- žaje, a njihova važnost dodatno je istaknuta tijekom fizičkog zatvaranja zbog pandemi- je bolesti COVID-19 i dodatnih poteškoća izazvanih potresom. Cilj je rada analizom usluga i sadržaja dostupnih korisnicima Knjižnica grada Zagreba tijekom zatvorenosti knjižnica te usluga i sadržaja nastalih u to vrijeme potvrditi pretpostavku o opravdanosti trajnog ulaganja u sljedeća područja: kvalitetnu mrežnu uslugu i sadržaje, nabavu elek- troničke građe, edukaciju djelatnika za vještine i znanja potrebne za rad na daljinu te u opremu koja podržava i rad na daljinu i povećan interes korisnika za mrežne usluge i sadržaje.
 Metodologija. Korištenje pojedinih digitalnih usluga i sadržaja analizirano je kroz statističke podatke prikupljene mrežnim alatom Google Analytics, bilježenjem prenoše- nja i korištenja digitalnih sadržaja KGZ-a u medijima i društvu. Podaci iz 2020. godine navedeni su za razdoblja prije, tijekom i nakon završetka zatvaranja knjižnica kako bi se došlo do zaključaka o promjenama u pristupu i korištenju usluga i sadržaja u tim poseb- nim okolnostima. Kao dopuna navedenim podacima iz 2020. godine, za dio digitalnih sadržaja i usluga napravljena je usporedba s podacima za 2019. godinu.
 Rezultati. Prikazana važnost ponude mrežnih usluga i sadržaja Knjižnica grada Zagreba (Digitalne zbirke, e-knjiga, katalog, Kalendar godišnjica, kanali društvenih medija, Pitajte knjižničare), koji bilježe značajne promjene korištenja tijekom fizičkog zatvaranja knjižnica, temelj su za određivanje prioriteta u planiranju daljnjeg razvoja Knjižnica grada Zagreba te poticaj za cjelovito sagledavanje posljedica izvanrednih do- gađaja kako bi se učinkovito djelovalo na daljnji rad i razvoj knjižnica.
 Originalnost i vrijednost. Osim što donosi prikaz jednog dijela knjižnične ponude dostupnog korisnicima u uvjetima potpunog zatvaranja velike knjižnične mreže, članak podupire pretpostavke o važnosti razvoja knjižničnih usluga i sadržaja temeljenih na informacijsko-komunikacijskim tehnologijama te važnosti trajnog ulaganja u digitalni segment knjižničnog poslovanja.
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Lončarić Šubaša, Tihana, and Ivana Blažeković. "Narodne knjižnice Bjelovarsko-bilogorske županije i kulturni turizam." Vjesnik bibliotekara Hrvatske 66, no. 3 (2023): 205–25. http://dx.doi.org/10.30754/vbh.66.3.1118.
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Cilj/svrha. Cilj je ovog istraživanja utvrditi koliko i kako narodne knjižnice s područja Bjelovarsko-bilogorske županije sudjeluju svojim uslugama i programima u kreiranju kulturno-turističke ponude, jesu li lokalne zajednice prepoznale njihov rad kao značajan za razvoj kulturnog turizma, jesu li vidljive kao zanimljivost turističkim posjetiteljima te u kojoj mjeri ostvaruju suradničke i partnerske odnose u promociji kulturnog turizma svoga kraja. Svrha je rada ukazati na važnost knjižnica kao ravnopravnog partnera u lokalnoj zajednici koji može pridonijeti u promicanju kulturnih dobara. Pristup/metodologija/dizajn. U prvom su dijelu rada prikazani osnovni teorijski pojmovi te dosadašnja istraživanja potencijala knjižnica u razvoju hrvatskog kulturnog turizma. Ukratko su opisane i značajke hrvatskog kulturnog turizma s posebnim naglaskom na Bjelovarsko-bilogorsku županiju. U drugom dijelu rada prikazani su rezultati istraživanja koje je provedeno među narodnim knjižnicama Bjelovarsko-bilogorske županije. Za potrebe istraživanja korišten je mrežni anketni upitnik koji je ispunilo 5 ravnateljica narodnih knjižnica s područja Bjelovarsko-bilogorske županije. Sudjelovanje knjižnica u razvoju kulturnog turizma na području Bjelovarsko-bilogorske županije provjereno je s osvrtom na usluge i programe zanimljive turistima, na vidljivost knjižnica turističkim posjetiteljima, na samoprocjenu turističkog potencijala knjižnica te na suradničke odnose u promociji kulturnog turizma. Rezultati. Rezultati istraživanja pokazali su da narodne knjižnice Bjelovarsko-bilogorske županije nude brojne usluge i programe korisne i zanimljive za turističke posjetitelje, ali nisu vidljive na odgovarajuć način kao pružatelji kulturno-turističkih sadržaja. Postoji velik prostor za napredak u stvaranju i održavanju suradničkih odnosa u razvoju narodnih knjižnica u turističkom smjeru. Ograničenja. Ovo je istraživanje provedeno samo na razini narodnih knjižnica Bjelovarsko-bilogorske županije. Za dobivanje opširnijih rezultata bilo bi dobro provesti istraživanje i u drugim vrstama knjižnica, među korisnicima knjižnica, među turističkim posjetiteljima, ali i među ostalim sudionicima kreiranja turističkih sadržaja. Originalnost. Rad prikazuje rezultate prvog istraživanja o sudjelovanju narodnih knjižnica Bjelovarsko-bilogorske županije u razvoju turističke ponude.
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Feng, Xiaojia, Zaozhi Song, Qihui Huang, et al. "AIM2 Promotes Gastric Cancer Cell Proliferation via the MAPK Signaling Pathway." Journal of Healthcare Engineering 2022 (April 7, 2022): 1–9. http://dx.doi.org/10.1155/2022/8756844.
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Background. Gastric cancer (GC) is a highly prevalent tumor type. The dysregulated expression of melanoma deficiency factor 2 (AIM2) has been observed in a range of tumor types. Herein, we explore the role of AIM2 in the regulation of GC progression. Methods. Gastric cancer cells BGC-823 and MGC-803 in logarithmic growth phase were divided into blank group (control), Control group (NC) and SH-AIM2 group, respectively. Control group and SH-AIM2 group were transfected with AIM2 NC and SH-AIM2, respectively. Nude mice were divided into blank group (control) and SH-AIM2 group, and the treatment methods were the same as above. Differential AIM2 expression in GC tissues was assessed via bioinformatics analyses, after which western blotting was used for analyzing the AIM2 levels in tumor and paracancerous tissues from five stomach cancer patients. In addition, qPCR and protein imprinting were used to assess AIM2 expression levels in GC cells, and AIM2 knockdown was conducted in MGC-803 and BGC-823cells, after which colony formation and EdU incorporation assay were utilized to assess cell proliferation. The oncogenic role of AIM2 was then assessed in mice and validated through immunohistochemical analyses. Results. GC tissues and cell lines exhibited marked AIM2 overexpression. AIM2 knockdown significantly impaired GC cell proliferation and migration, as confirmed through in vitro assays. In vivo experiments showed that both the increment ability and invasion and migration ability of AIM2 knockdown group were significantly lower than that of control and NC the change of AIM2 protein level would affect the change of MAPK pathway related protein level. Conclusions. AIM2 knockdown markedly suppresses the proliferation, migration, as well as invasion of GC cells via the inhibition of MAPK signaling, thereby slowing tumor progression. Overall, these results suggest that further analyses of AIM2 may offer clinically valuable insights that can aid in the treatment of human GC.
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Leclant, Jean. "Information sur le lancement d'une Campagne consacrée à la création du Musée national de la civilisation égyptienne au Caire et du musée de la Nubie à Assouan." Comptes-rendus des séances de l année - Académie des inscriptions et belles-lettres 129, no. 1 (1985): 204–5. http://dx.doi.org/10.3406/crai.1985.14256.
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Li, Jianbo, Guojian Zhang, Mingming Zhu, Xuemei Wang, and Xiao-Feng Li. "Establishment and Imaging Studies of Human Lung Cancer-Associated Brain Metastasis Animal Models." Journal of Medical Imaging and Health Informatics 9, no. 6 (2019): 1138–41. http://dx.doi.org/10.1166/jmihi.2019.2707.
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Background: Lung cancer is one of the malignant tumors with fast increase in morbidity and mortality, and great threat to human health and life. Methods: Animal models (n = 5) were performed by injecting 1 × 106 A549 cells in 0.1 mL phosphate buffer saline into nude mice through the left ventricle. Body weight of animals was measured every 3 days, and changes in the appearance and behavior were observed. Brain magnetic resonance imaging of 5 animals were performed using T1, T1 enhancement and T2 scan at the 4th, 6th, and 7th weeks after injected with tumor cells. Animals (n = 5) were sacrificed after the last magnetic resonance scan, and brain slices of the animals were prepared to conduct hematoxylin-eosin staining. Results: At the 4th weeks after inoculation of tumor cells, there was no obvious change in the appearance and behavior of animals and there were no obvious tumor metastases in the brains from brain magnetic resonance scan. At the 6th weeks, body weight of all animals (n = 5), one of which appeared paralysis in hind limb, decreased obviously, and results from MR scans showed there were tumor metastases in the brains of all animals. Results from brain magnetic resonance scan images of one animal at 4th, 6th, and 7th weeks showed tumor metastases appeared in the animal's brain and gradually grew bigger. Result from hematoxylin-eosin staining of brain slices showed multiple tumor metastases, consistent with the results of magnetic resonance imaging. Conclusions: Human lung cancer-associated brain metastasis animal models was successfully established, and micro-magnetic resonance imaging is a sensitive, accurate and non-invasive method for the detection of lung cancer brain metastases in mice through this study.
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Hall, J. "Enhancing the environmental rule of law and the interplay between the disclosure of incriminating information and enforcement." Tydskrif vir die Suid-Afrikaanse Reg 2021, no. 4 (2021): 631–55. http://dx.doi.org/10.47348/tsar/2021/i4a1.
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Om gevolg te gee aan die oppergesag van die reg met betrekking tot omgewingswetgewing, wat noodsaaklik is om die talle wêreldwye omgewingskrisisse die hoof te bied, moet regerings nakoming monitor en handhawing verseker. Voor 1994 het Suid-Afrika dit nie gedoen nie. Plaaslike wetgewing het nie tred gehou met internasionale tendense nie, en selfs waar daar regulering was, het die regering om ’n aantal redes min belangstelling daarin getoon om afdwinging ernstig op te neem. Die huidige Suid-Afrikaanse regsraamwerk verteenwoordig dus ’n drastiese verandering van ’n historiese benadering tot omgewingsmonitering en –handhawing wat veel te wense oorgelaat het. Hierdie nuwe regsraamwerk bied ’n goeie basis vir die uitvoering van die nakomings- en handhawingsfunksies. Bekendmaking van inligting vorm ’n integrale deel van die nakomings- en handhawingstelsel. Dit is ’n waardevolle hulpmiddel, aangesien dit die potensiaal het om nie net die nakomings- en handhawingspogings van die regering meer doeltreffend te maak nie, maar ook om die onvermydelike beperkings op die regering se vermoëns te bekamp. Dit is veral belangrik in die konteks van omgewingsoortredings, aangesien inligting van besondere belang is in die konteks van omgewingsbestuur. In teenstelling met baie ander misdade kan omgewingsoortredings potensieel ’n negatiewe impak hê op ’n wye verskeidenheid mense, soos werknemers en gemeenskappe, ver verby die fabrieksheining. Bekendmakings wat inkriminerend is, kan egter potensieel teenstrydig wees met die grondwetlike regte van beskuldigdes, veral die reg teen self-inkriminasie. Met hierdie bydrae ontleed die outeur die dryfvere agter die hervormde benadering van die regering ten opsigte van die afdwinging van omgewingswetgewing. Die outeur ondersoek ook die rol wat die bekendmaking van inkriminerende of potensieel inkriminerende inligting kan speel in verbeterde en geoptimaliseerde handhawing van omgewingswetgewing ten opsigte van besoedeling asook afvalbestuur-verwante oortredings deur maatskappye. Sommige van die vrae wat ontstaan uit die wisselwerking tussen die omgewingsreg, die reg op inligting en die regte van beskuldigdes, word ook oorweeg en bespreek veral ten opsigte van die reg teen selfinkriminering. Suid Afrikaanse howe het tot dusver nog nie die geleentheid gehad om uitspraak te lewer op verskeie van hierdie vrae nie. Die artikel sluit af met die opmerking dat die benadering tot die bekendmaking van inligting waarde het, maar dat daar ook struikelblokke is wanneer omgewingsregte en strafprosesregtelike waarborge almal ter sprake is, wat die mate waartoe daarop staatgemaak kan word effens beperk. Daar word voorgestel om met die daarstelling van ’n administratiewe boetestelsel sommige van hierdie knelpunte aan te spreek.
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Vrana, Radovan, and Jelena Pavičić. "Online sadržaji i usluge namijenjeni djeci na internetskim stranicama dječjih knjižnica u Hrvatskoj." Vjesnik bibliotekara Hrvatske 62, no. 1 (2019): 103–27. http://dx.doi.org/10.30754/vbh.62.1.679.
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<p><strong>Cilj</strong>. Cilj istraživanja u ovome radu bio je utvrditi postojanje sadržaja i usluga namijenjenih isključivo djeci na internetskim stranicama dječjih knjižnica u Hrvatskoj te odgovoriti na sljedeća istraživačka pitanja: postoje li i koje su vrste sadržaja (prema predstavljenom japanskom modelu) dostupne putem internetskih stranica dječjih knjižnica u Hrvatskoj i postoje li i koje su usluge za djecu dostupne putem internetskih stranica dječjih knjižnica u Hrvatskoj?</p> <p><strong>Pristup/metodologija/dizajn</strong>. U ovom je istraživanju provedena analiza online sadržaja internetskih stranica dječjih knjižnica u Hrvatskoj u sklopu svih dostupnih internetskih mjesta (bez iznimaka) narodnih knjižnica u Hrvatskoj. Ustanovljen je ukupan broj od 193 dostupna internetska mjesta narodnih knjižnica. Kriterij odabira internetskih stranica dječjih knjižnica u Hrvatskoj u ukupnom broju dostupnih internetskih mjesta narodnih knjižnica bile su one internetske stranice dječjih knjižnica u Hrvatskoj koje su nedvojbeno nudile online sadržaje i usluge namijenjene djeci, njih ukupno 32. Prilikom analize sadržaja internetskih stranica dječjih knjižnica u Hrvatskoj primijenjen je model CIRRI (Core Information Reference Research Instruction (CIRRI) Contents Model) koji su osmislili Kanazawa, Maruyama i Motoki.</p> <p><strong>Rezultati</strong>. Provedeno istraživanje ukazuje na činjenicu kako u odnosu na ukupan broj narodnih knjižnica u Hrvatskoj ne postoji znatan broj narodnih knjižnica koje na svojim internetskim stranicama nude sadržaje i usluge namijenjene djeci. Od svih dostupnih internetskih mjesta narodnih knjižnica u Hrvatskoj koje su pregledane i analizirane, bilo je moguće izdvojiti njih ukupno 32, a među izdvojene 32 rijetke su bile one internetske stranice dječjih knjižnica u Hrvatskoj koje su sadržajima i uslugama namijenjene isključivo djeci. Mnoge od njih teško je locirati u sklopu internetskih mjesta narodnih knjižnica jer nisu bile vidljivo istaknute, nisu bile redovito ažurirane i često su služile samo kao pokazatelji postojanja dječje knjižnice u prostorima narodne knjižnice te postojanja pojedinih stalnih programa pojedinih narodnih knjižnica za djecu koji se odvijaju u prostoru knjižnice. Rijetke su one internetske stranice dječjih knjižnica u Hrvatskoj za koje se može reći da zadovoljavaju potrebe djece za informacijama, znanjem i zabavom. Analizom sadržaja internetskih stranica dječjih knjižnica u Hrvatskoj moguće je zaključiti kako postoji znatan prostor za napredak u ponudi i organizaciji online sadržaja i online usluga za djecu.</p> <p><strong>Praktična primjena</strong>. Rezultate istraživanja moguće je primijeniti u procesu oblikovanja budućih internetskih stranica narodnih knjižnica uz pomoć primjera postojećih vrsta online sadržaja i online usluga.</p>
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Pažur, Ivana. "Knjižnični izvori i usluge za mobilne uređaje u visokoškolskim i srodnim knjižnicama." Vjesnik bibliotekara Hrvatske 62, no. 2 (2020): 1–32. http://dx.doi.org/10.30754/vbh.62.2.746.
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Cilj. Rad utvrđuje zastupljenost knjižničnih izvora i usluga prilagođenih za pristup putem mobilnih uređaja kod visokoškolskih i srodnih knjižnica koje podupiru znanstveni rad i visoko obrazovanje: Nacionalna i sveučilišna knjižnica u Zagrebu, sveučilišne knjižnice, općeznanstvene i specijalne knjižnice – instituti i zavodi. Pristup/metodologija/dizajn. Postavljena su tri istraživačka pitanja: 1) Koliko su se razmatrane visokoškolske i srodne knjižnice prilagodile korisnicima u smislu dostupnosti knjižničnih izvora i usluga za mobilne uređaje? 2) Koje su vrste knjižničnih izvora i usluga za mobilne uređaje u većoj, a koje u manjoj mjeri zastupljene u razmatranim visokoškolskim i srodnim knjižnicama? 3) Kakve su sličnosti i razlike između pojedinih kategorija razmatranih knjižnica s obzirom na implementiranost analiziranih knjižničnih izvora i usluga za mobilne uređaje? U provedbi istraživanja napravljena je analiza sadržaja 97 knjižničnih mrežnih mjesta prema 10 zadanih kriterija, a prisutnost svakog pojedinog kriterija s manje ili jednako 50 % smatrana je nedovoljnom zastupljenošću. Rezultati. Responzivne mrežne stranice zastupljene su kod 43 % knjižnica. Najzastupljenije su kod sveučilišnih i općeznanstvenih knjižnica (obje kategorije s po 50 %), slijede institutske i zavodske knjižnice (45 %), a najmanje su zastupljene među visokoškolskim knjižnicama (42 %). Samo jedna knjižnica (1 %) ima knjižničnu aplikaciju za mobilne uređaje. Nijedna razmatrana knjižnica nema aplikaciju knjižničnog kataloga za mobilne uređaje, dok 13 % knjižničnih kataloga ima responzivno mrežno sučelje. Knjižnice ne upućuju korisnike na pristup putem mobilnih uređaja bazama znanstvenih informacija i podataka, e-knjigama ili e-časopisima. Komunikaciju s korisnicima pomoću tekstualnih poruka ne nudi nijedna knjižnica. Profil na društvenoj mreži Facebook posjeduje 23 % knjižnica. Primjena novih tehnologija i usluga (QR, NFC, Beacon, AR) ne spominje se na većini mrežnih stranica razmatranih knjižnica i zastupljena je u rijetkim pojedinačnim slučajevima. Ukupno 29 % razmatranih knjižnica omogućava objedinjeno pretraživanje svih dostupnih e-izvora (discovery search): nude ga sve sveučilišne knjižnice (100 %), od visokoškolskih knjižnica nudi ga 28 %, a od institutskih i zavodskih knjižnica 20 %. Edukaciju o knjižničnim izvorima i uslugama za mobilne uređaje eksplicitno na svojim mrežnim stranicama ne spominje nijedna knjižnica. Od ukupnog broja razmatranih knjižnica čak 44 % knjižnica nema zadovoljen nijedan kriterij analize sadržaja, a od 10 kriterija najviše (30 %) ih je zastupljeno kod osam knjižnica. Rezultati pokazuju da izvori i usluge za mobilne uređaje nisu dovoljno (manje ili jednako 50 %) zastupljeni u ukupnom broju razmatranih knjižnica, kao ni kod pojedinačnih knjižnica. Originalnost/vrijednost. Prvi put je razmotrena i napravljena analiza sadržaja knjižničnih izvora i usluga hrvatskih knjižnica za mobilne uređaje, što daje uvid u postojeću situaciju i poticaj za razmišljanje o orijentaciji prema korisnicima takvih usluga.
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Chou, Ting-Chao David. "Abstract A017: Computer simulation and quantification of the mass-action law-base pharmacodynamics parameters for anti-cancer and anti-viral therapeutics for single drugs and their combinations." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A017. http://dx.doi.org/10.1158/1535-7163.targ-23-a017.
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Abstract The biophysical and biochemical fundamental principle of the mass-action law (MAL) was used as the solo model for broad-spectrum system analysis. These included linear and circular sequential analysis, pattern analysis, combinatorial analysis, and mathematical induction-deduction, for deriving unified general pharmacodynamics/biodynamics/combination index/and bioinformatics (PD/BD/CI/BI). The two unified general dose-effect dynamics theories are: “action” (Median-effect Eq., MEE) and “interaction” (Combination index Eq. CIE). All terms of MEE and CIE are dimensionless relativity ratios; thus, the applicability of the dynamics is regardless of unit (e.g., uM, IU, rad), mechanisms (e.g., sequential, ordered, random; competitive, non-competitive, uncompetitive), and physical states (e.g., chemicals, biologicals, radiation, photonic, and thermal effects), and their interactions. The unified “action” dynamics (MEE) is applicable for R&D for MAL identity’s basic-PD parameters: Dm, the median-effect dose, signifying potency; and m, the dynamic-order, signifying shapes of dose-effect curves (DEC), for single drugs or in combinations. The Dm and m values can be determined by computer simulation based on MEE and CIE algorithms computer software, which allows digital determination of synergism (CI&lt;1), additive effect (CI=1), and antagonism (CI&gt;1) by automated simulations, instantly, after Dose and Effect paired data entries. The MEE algorithm and plot (MEP) linearized DEC into straight lines. This linearization principle led to the minimum two data points theory (MTDPT), which adds “dose-zero” and “Dm)” two dose-data points to the PD algorithm by default, for dynamics simulations. The MTDPT is the theoretical basis for Econo-green, efficient, cost-effective biomedical research in vitro, animals, humans, environmental, agricultural, marine, and food sciences. This allows using small-size experimental studies, reducing cost, and increasing efficiency by computer simulation. This paper illustrates the examples (experimental or clinical trial protocol) of PD design, step-by-step, for dose-dependent PD computer analysis, for anti-cancer and anti-viral agents, e.g., fludelone +/- panaxytriol in vitro; microtubule-stabilization agent +/- T607 antineoplastic in colon carcinoma HCT116 tumor-bearing nude mice; as well as anti-HIV clinical trials [nucleoside reverse transcriptase inhibitor +/- Interferon], are used for detailed illustrations for study design, computerized data analysis, and automated print-out. Thus, the unified general MAL- PD/BD/CI/BI can be used in vitro, in animals, and in clinical trials, for digital informatics or ranking. It is worth noting that the Google Scholar and Web of Science bibliometrics (as of May 29, 2023), on the MAL-PD/CI original article (Chou TC & Talalay P, 1984), Review (Chou TC, 2006), and Perspectives (Chou TC, 2010) have received a total of 18,046 citations in over 1,500 journals. For relevant 2023 references, please visit https://doi.org/10.1016/j.jbc.2023.103419 and dx.doi.org/10.1124/jpet.122.185320. Citation Format: Ting-Chao David Chou. Computer simulation and quantification of the mass-action law-base pharmacodynamics parameters for anti-cancer and anti-viral therapeutics for single drugs and their combinations [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr A017.
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Nair, Praveen, Sarah Kolitz, Jason Funt, et al. "Abstract A134: Predicting activity of IMM-1-104 as single agent and in combination for patients with RAS or RAF mutant tumors." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A134. http://dx.doi.org/10.1158/1535-7163.targ-23-a134.
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Abstract Introduction: Many tumors are addicted to MAPK pathway activation, including the &gt;20% of human tumors with mutations in RAS or RAF1. IMM-1-104 is an oral once-daily treatment currently in Phase 1 in patients with RAS-mutant solid tumors [NCT05585320]. To date, drugs disrupting the MAPK pathway have done so chronically, leading to dose-limiting toxicities (DLTs) and poor response durability. In contrast, IMM-1-104 was designed to provide deep cyclic inhibition (DCI) of the MAPK pathway via a unique pharmacokinetic (PK) profile with high peak plasma drug levels and a near zero drug trough between doses. This promotes pulsatile inhibition of MEK, depriving tumors of sustained signaling of a critical oncogenic pathway while limiting toxicity and durability issues associated with chronic MEK inhibition. In Phase 1a dose escalation, no DLTs were observed, the plasma drug half-life was ~2-hours, and pharmacodynamic (PD) data were consistent with DCI. Phase 1b dose expansion is underway. Translational efforts are focused on identifying MAPK pathway addiction and sensitivity to IMM-1-104. Tumor models displaying patient-aligned genomic profiles against large patient databases such as AACR Project GENIE1 were tested in humanized 3D tumor growth assays (3D-TGA). Computational modeling based on response and in-house genomic data was used to inform identification of patient populations for IMM-1-104 monotherapy and potential combination opportunities. Experimental Procedures: Using cancer-specific, patient-aligned cell lines, IMM-1-104 activity was characterized in the 3D-TGA. Whole exome sequencing was performed to confirm alteration status, and a further subset subjected to RNA sequencing. Pharmacogenomic data were used to generate a model predictive of response to IMM-1-104 and identify biomarker-aligned patient subpopulations. Selected model predictions were then tested in subcutaneous tumor xenograft models in female BALB/c nude mice. Summary of New Data: Assessment of IMM-1-104 across &gt;190 patient-aligned models demonstrated diverse responses across a wide range of MAPK-driven tumor types, including those with RAS or RAF mutations. In addition to RAS, these data suggested additional potential for IMM-1-104 in BRAF-mutant disease. Therefore, IMM-1-104 was tested alone and with encorafenib in the HT-29 colorectal BRAFV600E mutant xenograft model. Monotherapy with either encorafenib or IMM-1-104 displayed superior tumor growth inhibition to binimetinib. IMM-1-104 in combination with encorafenib drove deeper regressions and superior durability of response in a head-to-head in vivo comparison versus binimetinib plus encorafenib. Conclusions: We used an integrated platform of translational experiments and informatics to identify patient-aligned model systems, prioritize factors relevant for response to IMM-1-104’s unique DCI profile, and elucidate combination opportunities to potentially inform clinical development strategies. Citation Format: Praveen Nair, Sarah Kolitz, Jason Funt, Jan de Jong, Peter King, Amy Yamamura, Mai Johnson, Jenny Zhang, Kevin D Fowler, Anna Travesa, Amy Axel, Chris Walker, Scott Barrett, Benjamin J Zeskind, Brett Hall. Predicting activity of IMM-1-104 as single agent and in combination for patients with RAS or RAF mutant tumors [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr A134.
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Yuri, Fernández Capote, and Espinosa Rodríguez Vivian. "SISTEMA DE INFORMACIÓN DE INTANGIBLES Y DESARROLLO ORGANIZACIONAL PARA LA TRANSFORMACIÓN DIGITAL EN LA EMPRESA CUBANA." Revista Cubana de Administración Pública y Empresarial 6, no. 1 (2022): e196. https://doi.org/10.5281/zenodo.6900166.
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<strong>Resumen</strong> La sociedad del conocimiento reconoce la velocidad e interconectividad global como premisas del desempeño empresarial competitivo. Se transita hacia un modelo de empresa 4.0, que apuesta por la inteligencia y gestión del conocimiento (intangibles) mediante tecnologías disponibles (grandes bases de datos-Bigdata; Internet de las cosas-IoT; Inteligencia Artificial-IA, inteligencia de máquina o aprendizaje automático; minería de datos o data mining-DM; cómputo en la nube y la niebla, entre otras). La industria cubana requiere transformaciones profundas para responder a este modelo, a la actualización económica y social del país, así como a la gestión de gobierno orientada a la innovación. Este artículo tiene como objetivo reflexionar sobre bases teórico metodológicas para un sistema de información de intangibles del desarrollo empresarial. Se apoya en la revisión bibliográfica y su contribución práctica es dotar a la empresa de referentes de partida para el diseño de sistemas automatizados de información y gestión de intangibles. <strong>Abstract</strong> The knowledge society recognizes speed and global interconnectivity as premises for competitive business performance. It is moving towards a 4.0 business model, which is committed to intelligence and knowledge management (intangibles) through available technologies (Bigdata; Internet of things-IoT; Artificial Intelligence-AI, machine learning; data mining-DM; computing in the cloud and fog, among others). The Cuban industry requires profound transformations to respond to this model, to the economic and social updating of the country, as well as to innovation-oriented government management. The objective of this article is to reflect on the theoretical and methodological bases for an information system of intangibles of business development. It is based on the bibliographic review and its practical contribution is to provide the company with starting references for the design of automated information systems and intangible management.
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Minárik, Peter, Jozef Golian, Daniela Mináriková, Adela Penesová, and Peter Chlebo. "Výživové údaje na obaloch potravín a perspektíva Nutri-Score označovania / Nutritional information on food packaging and the Nutri-Score labelling perspective." Laboratórna Diagnostika XXVII, no. 2/2022 (2022): 76–85. https://doi.org/10.5281/zenodo.7223618.
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<strong>SÚHRN</strong> Nutrične nekvalitná výživa je jedným z hlavných faktorov, ktoré podporujú výskyt chronických chorôb. Vzhľadom na veľký význam stravovania a výživy pri prevencii chronických chorôb je potravinová a nutričná gramotnosť dôležitou súčasťou celkovej zdravotnej gramotnosti. Potravinová a nutričná gramotnosť je viac než len súhrn akademických vedomostí o potravinách a živinách a patrí sem aj schopnosť prijatým informáciám rozumieť, ďalej vôľa a motivácia pre prijatie pozitívnych zmien v stravovaní, ako aj adekvátne konanie v súlade s nadobudnutými vedomosťami, a to spôsobom, ktorý je v súlade s uplatňovaním výživových cieľov a podpory dobrého zdravotného stavu. Medzi základné kategórie potravinovej a nutričnej gramotnosti patria znalosti o potravinách a výžive, stravovacie zručnosti, ako aj schopnosť praktického uplatňovania zdraviu prospešnej výživy s tvorbou správnych stravovacích rozhodnutí a návykov. Najnovšie sa do tejto gramotnosti započítavajú aj znalosti o vonkajších (ekologických) a socioekonomických faktoroch, vplývajúcich na stravovanie a výživu. Základné fakty a kľúčové odkazy o racionálnom stravovaní a „zdravej“ výžive udáva Svetová zdravotnícka organizácia (WHO). Európsky úrad pre bezpečnosť potravín (EFSA) vo svojom vedeckom stanovisku (2010) odporúča, aby všetky európske štáty stravovacie pretransformovali odporúčania založené na nutrientoch do vedecky podložených oficiálnych stravovacích odporúčaní založených na potravinách (<em>Food-based Dietary Guidelines</em>). Súčasťou týchto stravovacích odporúčaní majú byť edukačné vizuálne pomôcky, a to vo forme „zdravých“ tanierov alebo „zdravých“ potravinových pyramíd, vrátane názorných sprievodcov primeraných porcií jednotlivých potravín. Integrálnou zložkou nutričnej gramotnosti je aj chápanie výživových údajov na obaloch potravín. Perspektívnym spôsobom 5-stupňového farebného označovania nutričnej kvality na predných obaloch potravín v Európske únii je systém Nutri-Score. V súčasnosti je toto označovanie dobrovoľné. Európska komisia plánuje schváliť povinné označovanie všetkých balených potravín logom Nutri-Score do konca roka 2023. Alternatívnym označovaním nutričnej kvality potravín je v Taliansku vyvinutý systém Nutrinform Battery. <strong>ABSTRACT</strong> The incidence of obesity among adults and adolescents is on the rise in Slovakia and it is currently higher than the EU average. This is partly due to poor eating habits and low levels of physical activity. Nutritionally poor nutrition is one of the main factors that support the occurrence of chronic diseases. Due to the great importance of diet and nutrition in the prevention of chronic diseases, food and nutrition literacy is an important part of overall health literacy. Food and nutrition literacy is more than just a collection of academic knowledge about food and nutrients. It includes the ability to understand the information received, the will and motivation to accept positive dietary changes, as well as adequate action in accordance with the acquired knowledge, in a way that is in line with the implementation of nutritional goals and the promotion of good health. The basic categories of food and nutritional literacy include knowledge about food and nutrition, eating skills, as well as the ability to apply healthy nutrition in practice with the creation of the proper eating decisions and habits. Recently, this literacy also includes knowledge of external (ecological) and socioeconomic factors affecting diet and nutrition. The basic facts and key facts about a rational diet and "healthy" nutrition are given by the World Health Organization (WHO). In its scientific opinion (2010), the European Food Safety Authority (EFSA) recommended that all European countries transform nutrition-based dietary recommendations into scientifically supported food-based dietary guidelines. These dietary recommendations should include educational visual aids in the form of "healthy" plates or "healthy" food pyramids, including illustrative guides to appropriate food portions. Part of nutritional literacy is also understanding the nutrition information on food packaging. The Nutri-Score system is a promising way of 5-level colour nutrition labelling on the front-of-pack of the foods in the European Union. At present, this labelling is voluntary. The European Commission plans to approve the mandatory labelling of all packaged foods with the Nutri-Score logo by the end of 2023. The Nutrinform Battery system developed in Italy is an alternative labelling for the nutritional quality of food.
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Franco Franco, Manuel Dario. "Tecnología en dermatología: ¿Dónde estamos y hacia dónde vamos?" Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica 30, no. 2 (2023). http://dx.doi.org/10.29176/2590843x.1749.
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La dermatología no está exenta de los desarrollos tecnológicos que están ocurriendo y los cuales muchas veces damos por sentado que siempre han estado allí. El simple uso de la historia clínica electrónica realizada en computadores y almacenada en la gigantesca plataforma informativa que hoy llamamos “nube”, que nos permite tener fotos y seguimientos de acceso inmediato.
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Ríos Hilario, Ana Belén, and Blanca Gil Urdiciain. "Los datos bibliotecarios en la nube de datos:análisis de los datasets GLAM presentes en el LOD cloud diagram." Scire: representación y organización del conocimiento, September 2, 2015, 35–47. http://dx.doi.org/10.54886/scire.v21i2.4231.
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Se analiza la representación de los conjuntos de datos pertenecientes a galerías, bibliotecas, archivos y museos (GLAM) en la nube de los datos abiertos y vinculados. En primer lugar, se establecen las bases teóricas en las que se sustenta el análisis: por un lado, se define el concepto de linked open data (LOD); posteriormente, se delimitan las fuentes objeto de estudio, en concreto: el diagrama de la nube LOD en el que se exponen la totalidad de los conjuntos de datos; el Catálogo de datos enlazados, en donde se obtiene información individualizada de cada caso específico y el informe titulado Conjunto de datos, vocabularios de valores y conjuntos de elementos de metadatos, cuya tipología nos sirve para categorizar los datasets bibliotecarios. El análisis propiamente dicho se centra: primero en el estudio de la muestra de los datos examinados sobre la totalidad de la nube; segundo, en la categorización de dichos de conjuntos en función de la clasificación previamente establecida; finalmente, se describen los casos más representativos centrándose en la tecnología de datos vinculados empleada. Se concluye exponiendo los principales resultados obtenidos y estableciendo una serie de propuestas de mejora.