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Journal articles on the topic 'Nuclear atypia'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Visscher, Daniel W. "Apocrine Ductal Carcinoma In Situ Involving a Sclerosing Lesion With Adenosis: Report of a Case." Archives of Pathology & Laboratory Medicine 133, no. 11 (2009): 1817–21. http://dx.doi.org/10.5858/133.11.1817.

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Abstract Apocrine metaplasia is a ubiquitous component of the mammary fibrocystic change spectrum. Although mostly associated with cysts, apocrine metaplasia can also present as a proliferative lesion, rarely with cytologic atypism. Apocrine atypia is characterized by 3-fold nuclear enlargement, multiple nucleoli, and hyperchromatism and generally arises in florid adenosis or radial sclerosing lesions. Dramatic apocrine atypia may be very difficult to distinguish from apocrine ductal carcinoma in situ. The latter is distinguished from apocrine atypia by greater extent of the lesion (&gt;0.

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Varshney, Himanshu, Manish Kumar Sharma, C. S. Mahendran, and Ranvijay Tiwari. "A case series on reactive atypia findings in cytology examination of bronchoalveolar lavage samples." Santosh University Journal of Health Sciences 10, no. 1 (2024): 130–32. http://dx.doi.org/10.4103/sujhs.sujhs_26_24.

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ABSTRACT Reactive atypia in bronchoalveolar lavage (BAL) cells reflects cellular changes frequently observed in respiratory cytology, typically resulting from injury, inflammation, or irritation rather than malignancy. This review examines the nature, causes, and diagnostic implications of reactive atypia in BAL specimens. BAL is a diagnostic procedure used to collect cells from the lower respiratory tract. Identifying atypical cells in BAL samples poses a significant challenge, as their morphology can resemble that of neoplastic processes. Characteristics of reactive atypia include nuclear en

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M, Logaswari, Mark JA Koh, and Kesavan Sittampalam. "Atypical fibrous histiocytomas and pleomorphic fibroma-type lesions in a patient with li-fraumeni syndrome." Proceedings of Singapore Healthcare 32 (January 18, 2023): 201010582311520. http://dx.doi.org/10.1177/20101058231152047.

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Atypical fibrous histiocytomas are an uncommon but benign variant of dermatofibroma where the neoplastic cells can feature cytological atypia constituted by prominent nuclear enlargement, pleomorphism and multinucleated giant cells. Though these can have a degree of atypia, they have a benign course and a failure to recognize these tumors as benign can lead to misdiagnosis and overtreatment, particularly in patients with Li-Fraumeni syndrome who are known to be predisposed to various malignancies. Here, we report a patient with atypical fibrous histiocytomas and multiple pleomorphic fibroma-ty

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Asirvatham, Jaya Ruth, Maria Monica Garcia Falcone, and Celina G. Kleer. "Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls." Archives of Pathology & Laboratory Medicine 140, no. 10 (2016): 1045–51. http://dx.doi.org/10.5858/arpa.2016-0238-ra.

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Apocrine change in the breast is an extremely common finding. In most cases, the benign or malignant nature of the lesion is easily recognized. Apocrine adenosis is used to describe sclerosing adenosis with apocrine change. The term apocrine atypia is used when there is significant cytologic atypia in apocrine cells, characterized by a 3-fold nuclear enlargement, prominent/multiple nucleoli, and hyperchromasia. Atypical apocrine adenosis is diagnosed when apocrine adenosis and apocrine atypia are superimposed. However, there are no definite criteria to distinguish atypical apocrine adenosis fr

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Pyo, Jung-Soo, Dae Hyun Lim, Kyueng-Whan Min, Nae Yu Kim, Il Hwan Oh, and Byoung Kwan Son. "Diagnostic Assessment of Endoscopic Ultrasonography–Fine Needle Aspiration Cytology in the Pancreas: A Comparison between Liquid-Based Preparation and Conventional Smear." Medicina 60, no. 6 (2024): 930. http://dx.doi.org/10.3390/medicina60060930.

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Background and Objectives: This study aimed to elucidate the cytologic characteristics and diagnostic usefulness of endoscopic ultrasonography–fine needle aspiration cytology (EUS-FNAC) by comparing it with liquid-based preparation (LBP) and conventional smear (CS) in pancreas. Methods: The diagnostic categories (I through VII) were classified according to the World Health Organization Reporting System for Pancreaticobiliary Cytopathology. Ten cytologic features, including nuclear and additional features, were evaluated in 53 cases subjected to EUS-FNAC. Nuclear features comprised irregular nu

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Yasuda, Masatoshi. "Atypia and Surface Structure of Superficial Neoplasms of the Colon Less Than 10 mm in Diameter." Diagnostic and Therapeutic Endoscopy 2, no. 3 (1996): 135–46. http://dx.doi.org/10.1155/dte.2.135.

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Histological specimens of 30 distinct adenomas and 30 distinct carcinomas were studied by image analysis to quantify nuclear size and shape. These data were used to derive a discriminant equation, which permitted the lesions to be classified into two groups based on nuclear atypia. Next, 50 superficial type tumors of the colon (34 IIa lesions, 9 IIc + IIa lesions, and 7 IIc lesions) <10 mm in longest diameter were similarly analyzed. These lesions were classified into a high atypia index group (HAI group, 14 lesions) and a low atypia index group (LAI group, 36 lesions) by the above discrimi

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Kim, Hyunjin, Sangjoon Choi, Sung-Im Do, Sang Hwa Lee, Nara Yoon, and Hyun-Soo Kim. "Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases." Diagnostics 10, no. 8 (2020): 595. http://dx.doi.org/10.3390/diagnostics10080595.

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We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining se

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Słowińska-Klencka, Dorota, Bożena Popowicz, Dominika Kulczycka-Wojdala, et al. "Effective Use of microRNA, BRAF and Sonographic Risk Assessment in Bethesda III Thyroid Nodules Requires a Different Approach to Nodules with Features of Nuclear Atypia and Other Types of Atypia." Cancers 15, no. 17 (2023): 4287. http://dx.doi.org/10.3390/cancers15174287.

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The aim of the study was to analyze the diagnostic usefulness of the combined assessment of the ultrasound risk category of the nodule (evaluated with EU-TIRADS system), the presence of BRAF V600E mutation and the expression of selected microRNAs (miR-146b, miR-221 and miR-222) in Bethesda category III thyroid nodules, separately for cases with nuclear atypia (AUS-nuclear) and cases with other types of atypia (AUS-other). We evaluated 161 nodules (66 AUS-nuclear and 95 AUS-other) with known results of postoperative histopathological examination. The rate of cancer and the rate of PTC among can

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Bertoni, Franco, Luis Fernando Arias, Marco Alberghini, and Patrizia Bacchini. "Fibrous Dysplasia With Degenerative Atypia: A Benign Lesion Potentially Mistaken for Sarcoma." Archives of Pathology & Laboratory Medicine 128, no. 7 (2004): 794–96. http://dx.doi.org/10.5858/2004-128-794-fdwdaa.

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Abstract Fibrous dysplasia is a benign disorder of bone in which proliferating fibrous tissue replaces the bony spongiosa. Cytologic atypia is generally not considered a feature of this proliferating tissue. We present a case of fibrous dysplasia with marked atypical nuclear changes consistent with degenerative or regressive changes. A 42-year-old man presented with an osteolytic lesion of the right iliac bone. Histologic study demonstrated a fibro-osseous lesion with woven bone trabeculae and bland-looking fibrous tissue. Several areas showed atypical cells with enlarged pleomorphic nuclei an

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Travaglino, Antonio, Frediano Inzani, Angela Santoro, et al. "Endometrial Metaplastic/Reactive Changes Coexistent with Endometrial Hyperplasia and Carcinoma: A Morphological and Immunohistochemical Study." Diagnostics 12, no. 1 (2021): 63. http://dx.doi.org/10.3390/diagnostics12010063.

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The aim of this study was to assess the relationship between endometrial metaplastic/reactive changes (EMRCs) and endometrial neoplastic lesions. Twenty cases of “simple” (without architecture complexity) EMRCs coexistent with endometrial malignant/premalignant lesions, twenty cases of neoplasia-unassociated EMRCs, and eight cases of complex metaplastic lesions were assessed by immunohistochemistry. EMRCs coexisted with endometrioid carcinoma (n = 12), atypical endometrial hyperplasia (n = 3), serous carcinoma (n = 2), and clear cell carcinoma (n = 3). Neoplasia-associated EMRCs showed a mean

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Seneldir, Hatice, and Rabia Girgin. "Cytologic-histopathologic correlation of bethesda category III diagnosed cases in thyroid cytology and analysis according to the bethesda system for reporting thyroid cytopathology 2023." Medicine Science | International Medical Journal 12, no. 4 (2023): 1310. http://dx.doi.org/10.5455/medscience.2023.08.180.

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The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has been used by pathologists since 2010, providing a standardized language, updated in 2017 and finally in 2023. According to the latest update, category III has been divided into two subgroups: " Atypia of uncertain significance (AUS) -nuclear atypia" and "AUS-other." We aimed to analyze the risk of malignancy in patients diagnosed with category III (AUS, follicular lesion of uncertain significance (FLUS), or AUS/FLUS) and compare them based on recent changes in cytologic-histopathologic correlation. We retrospectively evaluate

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Liu, Jiaqi, Xianzun Tao, Yi Zhu, et al. "Abstract LB060: NMNAT-mediated NAD+ metabolism promotes glioma growth by modulating p53 post-translational modifications and nuclear atypia." Cancer Research 85, no. 8_Supplement_2 (2025): LB060. https://doi.org/10.1158/1538-7445.am2025-lb060.

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Abstract Gliomas are highly malignant brain tumors with poor prognosis and short survival. Nicotinamide adenine dinucleotide (NAD+) plays a critical role in cancer progression, yet anti-cancer therapies targeting NAD+ synthesis have had limited clinical success due to an incomplete understanding of its mechanisms. Here, we demonstrate the essential role of the NAD+ synthase nicotinamide mononucleotide adenylyltransferase (NMNAT) in glioma progression and its novel contribution to nuclear atypia. Analysis of the patient glioma transcriptomics dataset (GAPIA) indicated a strong correlation betwe

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Ribas, J. L., H. Mena, K. G. Braund, I. A. Sesterhenn, and M. Toivio-Kinnucan. "A Histologic and Immunocytochemical Study of Choroid Plexus Tumors of the Dog." Veterinary Pathology 26, no. 1 (1989): 55–64. http://dx.doi.org/10.1177/030098588902600109.

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Sixteen choroid plexus (CP) tumors in 12 male and four female adult dogs were analyzed microscopically. Tumors were in the lateral (six), third (six), and fourth (four) ventricles. The average age of the dogs was 6 years. Tumors were classified by the following criteria: 1) choroid plexus papilloma (CPP), which resembled normal choroid plexus and had low mitotic activity; 2) choroid plexus papilloma with atypical features (atypical CPP), which had increased cellular density, nuclear atypia, two to four mitoses per 40 × microscopic field, necrosis, and infiltration of the brain parenchyma and/o

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Layfield, Lester J., Rex C. Bentley, and Joseph M. Mirra. "Pseudoanaplastic Giant Cell Tumor of Bone." Archives of Pathology & Laboratory Medicine 123, no. 2 (1999): 163–66. http://dx.doi.org/10.5858/1999-123-0163-pgctob.

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Abstract Marked nuclear atypia can be found in a variety of benign mesenchymal tumors, including ancient schwannomas, symplastic leiomyomas, osteoblastomas, and chondromyxoid fibromas. Such nuclear atypia is believed to represent a degenerative phenomenon and does not indicate aggressive behavior. Separation of these pleomorphic but benign lesions from true sarcomas may be difficult. We are aware of only one prior description of such degenerative atypia in benign giant cell tumor of bone. We report a benign giant cell tumor of bone arising in the sacrum of a 21-year-old white female. Preoperat

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Johal, J. J., V. Mateescu, H. Dai, and S. M. Augustin. "Giant pilomatricoma with atypical features: report of a case of aggressive pilomatricoma in an adult." American Journal of Clinical Pathology 162, Supplement_1 (2024): S7. http://dx.doi.org/10.1093/ajcp/aqae129.014.

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Abstract Introduction/Objective Pilomatricoma, also known as pilomatrixoma or calcifying epithelioma of Malherbe, is a relatively common, benign tumor of the hair matrix. It typically presents as a small (~1cm), dermal based mass in the head and neck region of children and young adults (under 20 years) with predominance for males, but can occur in any age. In contrast, malignant pilomatricoma is typically larger (1 to 10 cm) and occurs later in life (50-60 years). Aggressive pilomatricoma is a variant of pilomatricoma that tends to occur in children and demonstrates atypical features such as i

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Tokuyama, Naoto, Akira Saito, Ryu Muraoka, et al. "Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features." Modern Pathology 35, no. 4 (2021): 533–38. http://dx.doi.org/10.1038/s41379-021-00955-y.

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AbstractNon-muscle invasive bladder cancer (NMIBC) generally has a good prognosis; however, recurrence after transurethral resection (TUR), the standard primary treatment, is a major problem. Clinical management after TUR has been based on risk classification using clinicopathological factors, but these classifications are not complete. In this study, we attempted to predict early recurrence of NMIBC based on machine learning of quantitative morphological features. In general, structural, cellular, and nuclear atypia are evaluated to determine cancer atypia. However, since it is difficult to a

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Tjendra, Youley, Yiqin Zuo, and Jaylou Velez. "Follicular Neoplasm and Nuclear Atypia: Establishing Diagnostic Criteria." Journal of the American Society of Cytopathology 12, no. 5 (2023): S62—S63. http://dx.doi.org/10.1016/j.jasc.2023.07.111.

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Fujiwara-Tani, Rina, Ayaka Okamoto, Hiroyuki Katsuragawa, et al. "BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer." International Journal of Molecular Sciences 22, no. 23 (2021): 12724. http://dx.doi.org/10.3390/ijms222312724.

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Gastric hyperplastic polyps (GHP) are frequently found to be benign polyps and have been considered to have a low carcinogenic potential. The characteristics of the hyperplastic polyp-associated gastric cancer (HPAGC) remain unclear. Therefore, we analyzed samples from 102 GHP patients and identified 20 low-grade atypical GHPs (19.6%), 7 high-grade atypical GHPs (6.9%), and 5 intramucosal cancer samples (4.9%). GHP atypia was more common in the elderly and increased with increasing polyp size. In particular, polyps larger than 1 cm were associated with a higher grade and cancer. Furthermore, m

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McCarthy, Aoife J., and Runjan Chetty. "Benign Smooth Muscle Tumors (Leiomyomas) of Deep Somatic Soft Tissue." Sarcoma 2018 (September 9, 2018): 1–6. http://dx.doi.org/10.1155/2018/2071394.

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Leiomyomas of deep soft tissue are extremely rare and should only be diagnosed following adherence to stringent histological criteria, namely, the absence of nuclear atypia and of coagulative tumor necrosis. Whether extremely low counts of, or even any, mitotic activity are acceptable when making a diagnosis of leiomyoma in deep soft tissue sites is controversial. The morphology and immunophenotype of smooth muscle tumors in deep soft tissue are similar to their counterparts irrespective of topography. It is interesting to note that leiomyomas of deep soft tissue (extremity and retroperitoneum

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Rooper, Lisa M., Jeffrey S. Iding, Jonathan D. Cuda, and Syed Z. Ali. "Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up." Acta Cytologica 60, no. 2 (2016): 173–78. http://dx.doi.org/10.1159/000445095.

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Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nu

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ZENGIN, Mehmet, Suat BENEK, Müjgan GÜRLER, and Merve ERYOL. "Arias-Stella reaction and frightening cytological changes in endocervical polyp: a rare case report." Anatolian Current Medical Journal 4, no. 4 (2022): 459–62. http://dx.doi.org/10.38053/acmj.1129795.

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The Arias-Stella (AS) reaction is hormone-dependent atypical endometrial changes characterized by hyperplasia, hypertrophy, vacuolization, pronounced nuclear atypia, pronounced nuclear pleomorphism, and prominent nuclear hyperchromasia in glandular epithelial cells. It is very rare to see AS-related changes in extra uterine areas, especially in an endocervical polyp. Since this benign lesion is very similar to misdiagnoses such as adenocarcinoma, it is very critical to recognize AS reaction in extrauterine areas. The interpretation of pathological findings involves many difficulties, for examp

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Park, Hyo Jin, Jae Hoon Moon, Cha Kyong Yom, et al. "Thyroid “Atypia of undetermined significance” with nuclear atypia has high rates of malignancy and BRAF mutation." Cancer Cytopathology 122, no. 7 (2014): 512–20. http://dx.doi.org/10.1002/cncy.21411.

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Udhayakumar, Bharathi, Lovely Jose, and Freena Rose. "Study of Histomorphological Spectrum of Mucinous Tumours of Ovary in a Tertiary Care Center in Thrissur, Kerala, India." Journal of Evidence Based Medicine and Healthcare 8, no. 9 (2021): 481–85. http://dx.doi.org/10.18410/jebmh/2021/94.

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BACKGROUND Mucinous ovarian tumours have various histomorphological patterns. Histopathological examination plays an important role in classifying ovarian tumours for prognosis and better treatment. Mucinous ovarian tumours are classified into benign cystadenomas, borderline mucinous tumours and malignant mucinous cystadenocarcinomas. This study was done to evaluate the distribution of ovarian tumours with respect to various parameters like age, laterality, size, loculation, stratification of cells, nuclear atypia, to study the gross morphological patterns of the various histopathological tumo

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Paschoalini, Rafael Bispo, Rozany Mucha Dufloth, Francisco Alves Moraes Neto, and Fernando C. Schmitt. "Cytological Criteria for Predicting the Luminal Phenotype of Breast Carcinoma." Acta Cytologica 60, no. 5 (2016): 406–12. http://dx.doi.org/10.1159/000448835.

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Background: Specific cytological criteria for the luminal phenotype of breast carcinoma, despite it being the most common and having a better prognosis as well as targeted therapies under study, remain to be established. Using fine-needle aspiration cytology (FNAC), we aimed to identify the luminal phenotype through the evaluation of cytological criteria recognized in routine practice. Methods: We correlated 169 FNACs of breast carcinomas with their tissue specimens, classified into phenotypes by immunohistochemistry (applying tissue microarray technology) as luminal A, luminal B, HER2 overexp

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D'Arcy, Clare, and Cecily Quinn. "Apocrine lesions of the breast: part 1 of a two-part review: benign, atypical and in situ apocrine proliferations of the breast." Journal of Clinical Pathology 72, no. 1 (2018): 1–6. http://dx.doi.org/10.1136/jclinpath-2018-205484.

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Apocrine morphology is a common phenomenon encountered in everyday breast pathology practice, and is defined as cuboidal or columnar cells exhibiting abundant eosinophilic granular cytoplasm, prominent apical granules, a low nuclear-cytoplasmic ratio, and round nuclei with pale chromatin and prominent nucleoli. Apocrine morphology is recognised in benign, atypical and malignant lesions of the breast. The morphology of apocrine atypia and non-high-grade apocrine ductal carcinoma in situ (DCIS) is less well defined due to the relative rarity of these lesions. In part 1 of this two-part review, w

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Kronqvist, Pauliina, Teijo Kuopio, Yrjö Collan, Csaba Horvath, and Ülle Tamm. "The Reproducibility of Nuclear Morphometric Measurements in Invasive Breast Carcinoma." Analytical Cellular Pathology 15, no. 1 (1997): 47–59. http://dx.doi.org/10.1155/1997/402125.

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The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer. The influence of biological variation and the selection of the measurement area was also tested. Morphometrically determined mean nuclear profile area (Pearson’sr0.89, grading efficiency (GE) 0.95) and standard deviation (SD) of nuclear profile area (Pearson’sr0.84, GE 0.89) showed high reproducibility. In this respect, nuclear morphometry equals with other established methods of quantitative pathology and exceeds the results

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Brown, Ciara, William Mangano, Stephanie Thompson, and Bryan Richmond. "Factors Predicting Thyroid Malignancy in Fine Needle Aspiration Biopsy Specimens Classified as Atypia of Uncertain Significance/Follicular Lesion of Uncertain Significance." American Surgeon 84, no. 7 (2018): 1207–13. http://dx.doi.org/10.1177/000313481808400740.

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The atypia of uncertain significance/follicular lesion of uncertain significance (AUS/FLUS) category of the Bethesda system for reporting thyroid cytopathology for fine needle aspiration biopsy (FNAB) has a predicted incidence of malignancy from 5 to 15 per cent. The literature has reported that suspicious ultrasound (SUS) characteristics can assist in predicting malignancy in thyroid biopsies. Some research suggests further subdivision of AUS/FLUS into nuclear atypia predominant or follicular predominant. We hypothesized that the rate of malignancy would be higher in AUS/FLUS biopsies with SU

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Qahtani, Sahar Ali, Khadiga A. Ismail, Howaida M. Hagag, et al. "Relation between Urine Cytological Findings and Renal Function in Patients with Kidney Stones in Taif, Saudi Arabia." Medicina 60, no. 10 (2024): 1630. http://dx.doi.org/10.3390/medicina60101630.

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Background and Objectives: Urine serves as a vital diagnostic fluid, and urine cytology analysis plays a crucial role in identifying urinary system illnesses such as bladder cancer and kidney stones. The Paris System for Reporting Urinary Cytology establishes a uniform method for diagnosing urinary tract cancer. This study aimed to provide valuable insights that can inform diagnostic strategies related to kidney stones and ultimately improve patient outcomes via the early detection of the cellular changes associated with kidney stones and their relation to kidney function tests. Materials and

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Milosevic, Zorica C., Mirjan M. Nadrljanski, Zorka M. Milovanovic, Nina Z. Gusic, Slavko S. Vucicevic, and Olga S. Radulovic. "Breast dynamic contrast enhanced MRI: fibrocystic changes presenting as a non-mass enhancement mimicking malignancy." Radiology and Oncology 51, no. 2 (2017): 130–36. http://dx.doi.org/10.1515/raon-2017-0016.

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Abstract Background We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination. Patients and methods Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy

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Epperson, Jonathan R., Necia M. Pope, and Margaret J. Abuzeid. "Rare Testicular Tumor Discovered by Assault: An Unusual Presentation of a Primary Testicular Neuroendocrine Tumor Grade 2." Case Reports in Pathology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/709352.

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Testicular neuroendocrine tumors (NET) or carcinoid tumors are rare neoplasms which represent 1% of all testicular tumors and can be divided into 3 subgroups: pure primary testicular NET, primary testicular NET associated with a teratoma, and NET metastases to the testis. We report an unusual presentation of a primary testicular neuroendocrine tumor in a 39-year-old male who presented after a physical altercation during a soccer game. Histology showed a diffuse infiltrating tumor with extensive involvement of the tunica albuginea and tunica vaginalis. Immunohistochemical expression of CD56, sy

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VandenBussche, Christopher J., Christina Adams, Syed Z. Ali, and Matthew T. Olson. "Cytotechnologist Performance for Screening Hürthle Cell Atypia in Indeterminate Thyroid Fine-Needle Aspirates." Acta Cytologica 59, no. 5 (2015): 377–83. http://dx.doi.org/10.1159/000441939.

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Objectives: We have previously shown that specimens diagnosed as containing Hürthle cells have a 12% chance of being malignant if they are classified as atypia of undetermined significance (AUS-HC). The identification of Hürthle cells by cytotechnologists (CTs) during screening can improve cytopathologist efficiency and may prevent diagnostic errors due to the oversights of focal findings. Here, we examine the performance of our institutional CTs when screening for Hürthle cell atypia in thyroid fine-needle aspiration (FNA) specimens. Study Design: Information on 8,814 thyroid cytopathology sp

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Villarreal, Paula Patricia, Rahul Pal, Suimin Qiu, et al. "Label-Free Imaging and Histo-Optical Evaluation of Head and Neck Cancers with Multiphoton Autofluorescence Microscopy." Cancers 15, no. 4 (2023): 1302. http://dx.doi.org/10.3390/cancers15041302.

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Depth-resolved label-free optical imaging by the method of multiphoton autofluorescence microscopy (MPAM) may offer new ways to examine cellular and extracellular atypia associated with epithelial squamous cell carcinoma (SCC). MPAM was evaluated for its ability to identify cellular and microstructural atypia in head and neck tissues from resected discarded tumor tissue. Three-dimensional image volumes were obtained from tissues from the floor of the mouth, tongue, and larynx, and were then processed for histology. MPAM micrographs were evaluated for qualitative metrics of cell atypia and quan

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Elhafey, Ahmed S., John C. Papadimitriou, Mohamed S. El-Hakim, Ahmed I. El-Said, Bahaa B. Ghannam, and Steven G. Silverberg. "Computerized Image Analysis of p53 and Proliferating Cell Nuclear Antigen Expression in Benign, Hyperplastic, and Malignant Endometrium." Archives of Pathology & Laboratory Medicine 125, no. 7 (2001): 872–79. http://dx.doi.org/10.5858/2001-125-0872-ciaopa.

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Abstract Context.—The endometrium is an intrinsically dynamic tissue with great capability for regeneration and proliferation; consequently, there is some overlap between features seen in benign, premalignant, and malignant lesions. This leads to marked intrabiopsy, interbiopsy, and interobserver variability. Objective.—We studied the specificity and sensitivity of computerized image analysis of molecular markers to evaluate its potential use as a diagnostic tool. Design.—Specimens from 100 patients were examined and the following histologic diagnoses were assigned: proliferative endometrium (

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Moond, Vishali, Preeti Diwaker, Reshma Golamari, and Rohit Jain. "Intramuscular ancient schwannoma of the axillary nerve." BMJ Case Reports 14, no. 5 (2021): e239445. http://dx.doi.org/10.1136/bcr-2020-239445.

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We present the case of an adolescent with an intramuscular ancient schwannoma of the axillary nerve which, to the best of our knowledge, has not been reported before. Due to its deep location, intramuscular schwannoma has less clinical signs and hence, is difficult to diagnose. Ancient schwannoma, characterised by degeneration due to long course, is rare and can be mistaken for malignancy due to heterogeneous intensity and degeneration evident on MRI and nuclear atypia on histopathology. It is important to differentiate it from malignancy based on a clinically benign swelling with a long histo

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Mlika, Mona, Manel Limam, Aida Benzarti, and Faouzi Mezni. "Impact on survival of nuclear atypia in epithelioid malignant mesothelioma." Advances in Respiratory Medicine 87, no. 2 (2019): 90–95. http://dx.doi.org/10.5603/arm.2019.0015.

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Zhu, Allen, Aliya N. Husain, Andrew Hermina, et al. "Association of somatic mutations and histologic subtype/grade on prognosis and PD-L1 expression in mesothelioma." Journal of Clinical Oncology 41, no. 16_suppl (2023): 8507. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.8507.

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8507 Background: Mesothelioma includes epithelioid, sarcomatoid, and biphasic histologic subtypes, and the epithelioid subtype is histologically graded based on mitotic count and nuclear atypia. Correlation between the most common somatic mutations ( BAP1, NF2, TP53, CDKN2A), and overall survival is poorly understood. High PD-L1 expression is a poor prognostic factor for survival and may be a predictor of response to immunotherapy. Few studies have evaluated the relationships between these factors. Methods: We performed a retrospective study in 217 patients with pleural, peritoneal and bicavit

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Barnhill, Raymond L., George C. Roush, and Paul H. Duray. "Correlation of histologic architectural and cytoplasmic features with nuclear atypia in atypical (dysplastic) nevomelanocytic nevi." Human Pathology 21, no. 1 (1990): 51–58. http://dx.doi.org/10.1016/0046-8177(90)90075-g.

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Eisa, Naseem, Ahsan Khan, Mutaal Akhter, et al. "Both Ultrasound Features and Nuclear Atypia are Associated with Malignancy in Thyroid Nodules with Atypia of Undetermined Significance." Annals of Surgical Oncology 25, no. 13 (2018): 3913–18. http://dx.doi.org/10.1245/s10434-018-6826-6.

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Fujita, Hirotaka, Takuma Tajiri, Tomohisa Machida, et al. "Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas." Acta Cytologica 62, no. 3 (2018): 223–30. http://dx.doi.org/10.1159/000487701.

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Objective: The aim of this study was to determine whether intraoperative cytological evaluation of squash preparations is of benefit for differentiating high-grade from low-grade astrocytomas. Methods: Squash preparations of 42 astrocytomas were classified histologically according to the World Health Organization (WHO) 2007 classification system as grade II (n = 12), grade III (n = 11), and grade IV (n = 19) and were divided into 2 groups, namely a low-grade group (grade II) and a high-grade group (grades III and IV). The focus was on morphological cell and vessel characteristics, namely nucle

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Rivera Rolon, Maria del Mar, Dyron Allen, Gwyn Richardson, and Cecilia Clement. "Abdominal Wall Clear Cell Carcinoma: Case Report of a Rare Event with Potential Diagnostic Difficulties." Case Reports in Pathology 2019 (July 18, 2019): 1–7. http://dx.doi.org/10.1155/2019/1695734.

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Clear cell carcinoma (CCC) is a well-known aggressive histological type of carcinoma, predominantly seen in ovary and endometrium. However, CCC arising in abdominal wall is a very rare event. We report a case of a 48-year-old woman with an abdominal wall mass at her cesarean section (c-section) scar, which increased in size and became painful in the last months. Radiology revealed a 7 cm mass in the right inferior rectus muscle sheath, suggestive of endometriosis. An irregular, firm mass was resected, densely adherent to the rectus muscle and pubic bone. Frozen section revealed a multicystic l

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Capozzi, Vito Andrea, Elisa Scarpelli, Sara dell’Omo, et al. "Atypical Endometriosis: A Comprehensive Systematic Review of Pathological Patterns and Diagnostic Challenges." Biomedicines 12, no. 6 (2024): 1209. http://dx.doi.org/10.3390/biomedicines12061209.

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Endometriosis is a benign condition affecting women of reproductive age. A potential association with ovarian cancer has been documented. Atypical endometriosis (AE) is characterized by deviations from the typical microscopic appearance of endometriosis, including cytologic and architectural atypia. AE has been recognized as a potential precursor to endometriosis-associated ovarian cancers (EAOC), particularly endometrioid and clear cell subtypes. AE presents challenges in diagnosis due to its diverse clinical and pathological features, often requiring careful histological evaluation for accur

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Kholová, Ivana, David Kalfert, Jarkko Lintusaari, Erja Rajakorpi, and Marie Ludvíková. "Follicular Epithelial Dysplasia as Hashimoto Thyroiditis-Related Atypia: a Series of 91 Specimens." Endocrine Pathology 32, no. 3 (2021): 368–74. http://dx.doi.org/10.1007/s12022-021-09679-w.

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AbstractFollicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. In this study, we retrospectively analyzed 91 specimens of thyroid gland surgical resections with FED during a 10-year-period at the university hospital pathology department. The study population consisted of 68 females and 15 ma

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Heryak, S. M., T. Yu Adam, P. R. Selskyi, I. V. Korda, and V. Yu Kuchmii. "Early pathomorphological markers of oncogenesis in atypical endometrial hyperplasia in patients with polyposis." Reproductive health of woman, no. 8 (November 20, 2024): 31–36. https://doi.org/10.30841/2708-8731.8.2024.320079.

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Large clinical studies have established that usually both endometrial and cervical polyps are benign pathologies, but in 0.2–1.5% their malignant transformation may occur, which is more often diagnosed in women with risk factors.Management of patients with polyps and endometrial hyperplasia depends on many factors and requires the establishment of clear hysteroscopic and morphological criteria by which it is possible to reliably predict the oncological risk, timely determine adequate treatment and its results.The objective: to study the pathomorphological characteristics of endometrial hyperpl

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Shukla, Prakriti, and Tushar Ojha. "Risk Prediction of Bladder Carcinomas in Atypical Urine Specimens by Redefining Diagnostic Cytomorphological Criteria." Acta Medica International 12, no. 1 (2025): 1–6. https://doi.org/10.4103/amit.amit_92_24.

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Abstract Introduction: Urine cytology in bladder tumors is challenging due to the lack of definite cytomorphological criteria in categorizing atypical cases. The study aims to re-evaluate atypia in the light of three definitive cytological parameters (high N/C ratio, hyperchromasia, and irregular nuclear contours) and correlate with the follow-up histopathology and cytopathology with an attempt to redefine the morphological features that would aid in distinguishing reactive atypia from malignancy. Materials and Methods: A retrospective analysis of 56 atypical urine specimens was performed cons

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MRCOG, Sun Kuie Tay, David Jenkins MRCPath, and Albert Singer. "Management of Squamous Atypia (Borderline Nuclear Abnormalities): Repeat Cytology or Colposcopy?" Australian and New Zealand Journal of Obstetrics and Gynaecology 27, no. 2 (1987): 140–41. http://dx.doi.org/10.1111/j.1479-828x.1987.tb00965.x.

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Gandomkar, Ziba, Patrick C. Brennan, and Claudia Mello-Thoms. "Computer-Assisted Nuclear Atypia Scoring of Breast Cancer: a Preliminary Study." Journal of Digital Imaging 32, no. 5 (2019): 702–12. http://dx.doi.org/10.1007/s10278-019-00181-8.

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Postier, Russell G., Megan R. Lerner, Stan A. Lightfoot, et al. "DNA Ploidy and Markovian Analysis of Neoplastic Progression in Experimental Pancreatic Cancer." Journal of Histochemistry & Cytochemistry 51, no. 3 (2003): 303–9. http://dx.doi.org/10.1177/002215540305100305.

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Computer-assisted analysis of DNA ploidy and nuclear morphology were used to elucidate changes in the cell nucleus that occur during the development of experimental pancreatic cancer. Ductal pancreatic adenocarcinoma was induced in 49 Syrian hamsters by SC injection of N-nitrosobis (2-oxopropyl) amine; twenty hamsters served as controls. Groups of animals were sacrificed every 4 weeks for 20 weeks and adjacent sections of pancreatic tissue were H&E and Feulgen-stained for light microscopy and computer assisted cytometry. Pancreatic ductal cells were classified as normal, atypical, or malig

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Sharma, Saniya, Nalini Gupta, Navneet Singh, Rini Chaturvedi, Digambar Behera, and Arvind Rajwanshi. "Cytomorphological features as predictors of epidermal growth factor receptor mutation status in lung adenocarcinoma." CytoJournal 15 (April 2, 2018): 11. http://dx.doi.org/10.4103/cytojournal.cytojournal_45_17.

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Background: Epidermal growth factor receptor mutation-positive (EGFR-p) lung adenocarcinomas are sensitive to tyrosine kinase inhibitors. Although histopathological subtype is an independent predictor of mutation status, there is a paucity of data on the cytomorphological features correlating with the EGFR mutation status. Therefore, the aim of this study was to determine whether certain cytomorphological features correlate with EGFR mutation in lung adenocarcinoma. Materials and Methods: A retrospective analysis of 48 lung adenocarcinoma cases diagnosed on fine needle aspiration cytology with

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Glass, Ryan, Lisa Rosen, Karen Chau, et al. "Analysis of the Cytomorphological Features in Atypical Urine Specimens following Application of The Paris System for Reporting Urinary Cytology." Acta Cytologica 62, no. 1 (2017): 54–61. http://dx.doi.org/10.1159/000481278.

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Background: This study investigates the use of The Paris System (TPS) for Reporting Urinary Cytopathology and examines the performance of individual and combined morphological features in atypical urine cytologies. Methods: We reviewed 118 atypical cytologies with subsequent bladder biopsies for the presence of several morphological features and reclassified them into Paris System categories. The sensitivity and specificity of individual and combined features were calculated along with the risk of malignancy. Results: An elevated nuclear-to-cytoplasmic ratio was only predictive of malignancy i

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Melson, Gabriella, Elie Saliba, Shreya Patel, Richard Eisen, and Candice E. Brem. "Clear Cell Acanthoma with Malignant Cytologic Features: A Case Report and Review of the Literature." Dermatopathology 9, no. 4 (2022): 355–60. http://dx.doi.org/10.3390/dermatopathology9040041.

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Clear cell acanthoma (CCA) is classically considered a benign epidermal tumor, although rare case reports have described CCA with malignant features. Here, we present a case of a patient with a biopsy proven CCA that regrew post-biopsy and was subsequently completely excised. Histologic examination of the tumor in the excision specimen revealed malignant cytologic features that were not present in the initial biopsy. A review of the literature identified five additional cases of CCA with similar malignant cytologic features. On analysis, common histopathologic characteristics included cellular

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