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Journal articles on the topic 'Nuclear Hyperchromasia'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Rahul, Dhameja Neeraj, Pandey Vikash, Garg Sanjoli, and Sharma Divya. "An unusual Case Report of Papillary Thyroid Carcinoma with Columnar Cell Variant Diagnosed by FNAC." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 226–28. https://doi.org/10.5281/zenodo.14591901.

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<strong>Background:</strong> The columnar cell variant of papillary carcinoma of thyroid are uncommon variant and regarded as more aggressive form as compared to more common classic papillary and follicular subtypes. <strong>Case Report:</strong> A 30 year male presents with midline nodular swelling measured 2.5×2.5 cm, since one year. On examination swelling was firm, moved with deglutition and non-tender. The aspirate are hypercellular showing large fragments of cells showing nuclear overlapping with oval enlarged nucleus with fine chromatin, grooving ing and inclusions

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Safiya, Javed Raima Kalhoro Mozna Taplur Fida Hussain Shankar Lal Rathi Usha Isaac. "EARLY DETECTION OF CERVICAL CANCER BASED ON HPV INFECTION IN PAP SMEAR USING MORPHOLOGICAL METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 14820–24. https://doi.org/10.5281/zenodo.3370330.

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<em>In developing countries cervical cancer is a leading cause of death in females.  In more than 90% of cases, these carcinomas are etiologically related to human papilloma virus infection. In developed countries HPV can be easily detected by PCR methods but these methods are very costly and not affordable. The purpose of this study is to found  effective, low-cost, less time consuming  method in our set up for early detection of cervical cancer.   Current study was conducted in Isra university hospital, Hyderabad, Pakistan.  Total 100 samples were collected from

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3

Teoman, Gizem, Ayten Livaoglu, Hatice Kucuk, and Afs ¸ın Rahman Murtezaoglu. "The importance of histomorphological features and ERG expression in the diagnosis of malignancy in cases with atypical small acinar proliferation." Journal of Pathology and Translational Medicine 58, no. 3 (2024): 134–40. http://dx.doi.org/10.4132/jptm.2024.03.18.

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Background: Atypical small acinar proliferation (ASAP) cases typically require rebiopsy, which are invasive and associated with increased risk of complications. Our aim in this study was to determine the importance of laboratory and histological findings and E-26 transformation-specific-related gene (ERG) expression in the diagnosis of malignancy. Methods: Between March 2016 and March 2022, 84 patients who were diagnosed with ASAP on biopsy or rebiopsy were included in the study. Clinical-laboratory features of age, serum prostate-specific antigen level, and histopathological features were com

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Renshaw, Andrew A., Mary R. Schwartz, Edward Wang, Jennifer Haja, and Jonathan H. Hughes. "Cytologic Features of Adenocarcinoma, Not Otherwise Specified, in Conventional Smears: Comparison of Cases That Performed Poorly With Those That Performed Well in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology." Archives of Pathology & Laboratory Medicine 130, no. 1 (2006): 23–26. http://dx.doi.org/10.5858/2006-130-23-cfoano.

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Abstract Context.—Characteristic cytologic features have been identified that distinguish cases that are consistently identified from those that are sometimes missed in the College of American Pathologists Gynecologic Cytology Program for a variety of different lesions and preparations. Objectives.—To compare the cytologic features of cases of adenocarcinoma, not otherwise specified (NOS), in conventional smears that perform poorly and well. Design.—The cytologic features of 21 conventional smear cases of adenocarcinoma, NOS, that performed poorly in the College of American Pathologists Interl

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ZENGIN, Mehmet, Suat BENEK, Müjgan GÜRLER, and Merve ERYOL. "Arias-Stella reaction and frightening cytological changes in endocervical polyp: a rare case report." Anatolian Current Medical Journal 4, no. 4 (2022): 459–62. http://dx.doi.org/10.38053/acmj.1129795.

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The Arias-Stella (AS) reaction is hormone-dependent atypical endometrial changes characterized by hyperplasia, hypertrophy, vacuolization, pronounced nuclear atypia, pronounced nuclear pleomorphism, and prominent nuclear hyperchromasia in glandular epithelial cells. It is very rare to see AS-related changes in extra uterine areas, especially in an endocervical polyp. Since this benign lesion is very similar to misdiagnoses such as adenocarcinoma, it is very critical to recognize AS reaction in extrauterine areas. The interpretation of pathological findings involves many difficulties, for examp

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Shidham, Vinod B. "Diagnostic pitfalls in effusion fluid cytology." Cytojournal 18 (December 6, 2021): 33. http://dx.doi.org/10.25259/cmas_02_04_2021.

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Effusion fluid cytology has propensity for both false positives (in up to 0.5%) and false negatives (in up to 30%) results. Methodical approach from collection step to final interpretation stage could prevent both false positives and false negatives, if the interpreter is familiar with various factors responsible for diagnostic pitfalls in effusion fluid cytology. For this discussion, these factors are categorized as mentioned below: Surface tension-related alterations in cytomorphology Improper specimen processing Many faces of reactive mesothelial cells, overlapping with those of cancer cell

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Kim, Hyunjin, Sangjoon Choi, Sung-Im Do, Sang Hwa Lee, Nara Yoon, and Hyun-Soo Kim. "Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases." Diagnostics 10, no. 8 (2020): 595. http://dx.doi.org/10.3390/diagnostics10080595.

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We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining se

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Fischer, Edgar G. "Nuclear Morphology and the Biology of Cancer Cells." Acta Cytologica 64, no. 6 (2020): 511–19. http://dx.doi.org/10.1159/000508780.

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<b><i>Background:</i></b> For more than a century, diagnostic pathologists have used morphologic abnormalities of the nucleus as essential diagnostic features to distinguish benign from malignant cells. These features include nuclear enlargement and increased nuclear-to-cytoplasmic ratio, nuclear membrane irregularities, hyperchromasia, and abnormal chromatin distribution. As our knowledge about the genetic and epigenetic abnormalities of cancer cells has increased in recent decades, the pathophysiologic mechanisms that underlie these morphologic abnormalities remain in

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9

Murzaeva, D. A., Yu M. Zabrodskaya, A. A. Dolgushin, L. N. Dobrogorskaya, and A. Y. Orlov. "Retrospective cohort study of morphological features of recurrent schwannomas and neurofibromas." Sechenov Medical Journal 12, no. 4 (2021): 29–38. http://dx.doi.org/10.47093/2218-7332.2021.12.4.29-38.

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Recurrences of benign peripheral nerves sheaths tumours (BPNST) after total resection were described in 2.6–11.0% of patients. The significance of the histological features of recurrent BPNST is still insufficiently studied.Aim. To compare the pathomorphological features of recurrent and non-recurrent BPNST (schwannomas and neurofibromas).Materials and methods. A retrospective assessment was made of 101 patients with BPNST with a degree of anaplasia corresponding not more than Grade I. Recurrence of BPNST developed in 13 (12.9%) cases. The study included patients with histological archive: the

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Arvind, Chouhan, and Ahmad Fuzail. "Study of FNAC in Breast Lesions." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 1364–70. https://doi.org/10.5281/zenodo.12680317.

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<strong>Background:</strong> Fine needle aspiration cytology (FNAC) was described and practiced by Martin and Ellis in 1930. All detected breast lesions are not malignant and all the benign masses do not progress to cancer; nevertheless the precision of the final diagnosis can be greatly increased by radiological imaging (mammography, ultrasonography) and pathological diagnosis.6 Breast cancer accounts for the most common cause of cancer related death in women. Method – The study was designed at Department of Pathology, Siddhanta Red Cross Hospital, a tertiary health care center in

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Zhai, Jing. "High-Grade Urothelial Carcinoma." CMAS Journal 1 (July 16, 2024): 7. http://dx.doi.org/10.25259/cmasj_04_04.

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High-grade urothelial carcinoma (HGUC) is a clinically aggressive form of cancer that poses a high risk of progressing to invasive carcinoma. Urine cytology is a powerful tool for diagnosing HGUC and for monitoring patients with established HGUC. The Paris System is the standard diagnostic terminology for urine cytology. The diagnostic criteria for HGUC include nuclear enlargement with a high nuclear-to-cytoplasmic ratio of 0.7 or greater, moderate-to-severe hyperchromasia, irregular nuclear membrane outlines, and coarse/clumped chromatin, in at least 5–10 malignant cells. Various variants of

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Z. Allaylah, Tawfiq, Abdulrahman E. Alraddadi, Abdulrahman M. Alrajhi, Ibrahim S. Alshaygy, and Ahmed Alhumaidi. "CASE REPORT OF AN EPITHELIOID VARIANT OF KAPOSI SARCOMA: A RARE MIMIC OF ANGIOSARCOMA." International Journal of Advanced Research 10, no. 06 (2022): 819–25. http://dx.doi.org/10.21474/ijar01/14956.

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Cutaneous Kaposi sarcoma (KS) is a vascular neoplasm with a broad spectrumclinicopathology. An epithelioid morphology, a rare recent variant of KS, with many variants of KS that may mimic other vascular neoplasms poses a diagnostic challenge. We report on a 75-year-old Saudi man HIV- negative who had been diagnosed with classical KS on the right foot 8 years before the present episode. Histopathological findings of the new lesion included areas showing epithelioid cells with moderate pleomorphism, growing in solid sheets. The epithelioid cells show nuclear enlargement and hyperchromasia mimick

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Varshney, Himanshu, Manish Kumar Sharma, C. S. Mahendran, and Ranvijay Tiwari. "A case series on reactive atypia findings in cytology examination of bronchoalveolar lavage samples." Santosh University Journal of Health Sciences 10, no. 1 (2024): 130–32. http://dx.doi.org/10.4103/sujhs.sujhs_26_24.

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ABSTRACT Reactive atypia in bronchoalveolar lavage (BAL) cells reflects cellular changes frequently observed in respiratory cytology, typically resulting from injury, inflammation, or irritation rather than malignancy. This review examines the nature, causes, and diagnostic implications of reactive atypia in BAL specimens. BAL is a diagnostic procedure used to collect cells from the lower respiratory tract. Identifying atypical cells in BAL samples poses a significant challenge, as their morphology can resemble that of neoplastic processes. Characteristics of reactive atypia include nuclear en

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Glass, Ryan, Lisa Rosen, Karen Chau, et al. "Analysis of the Cytomorphological Features in Atypical Urine Specimens following Application of The Paris System for Reporting Urinary Cytology." Acta Cytologica 62, no. 1 (2017): 54–61. http://dx.doi.org/10.1159/000481278.

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Background: This study investigates the use of The Paris System (TPS) for Reporting Urinary Cytopathology and examines the performance of individual and combined morphological features in atypical urine cytologies. Methods: We reviewed 118 atypical cytologies with subsequent bladder biopsies for the presence of several morphological features and reclassified them into Paris System categories. The sensitivity and specificity of individual and combined features were calculated along with the risk of malignancy. Results: An elevated nuclear-to-cytoplasmic ratio was only predictive of malignancy i

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Iczkowski, Kenneth A., and David G. Bostwick. "Criteria for Biopsy Diagnosis of Minimal Volume Prostatic Adenocarcinoma." Archives of Pathology & Laboratory Medicine 124, no. 1 (2000): 98–107. http://dx.doi.org/10.5858/2000-124-0098-cfbdom.

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Abstract Context.—Minimal volume prostatic adenocarcinoma (defined as involving less than 5% of biopsy tissue) is diagnosed increasingly today because of successful cancer screening. We previously described the diagnostic category called atypical small acinar proliferation (ASAP), suspicious for but not diagnostic of malignancy, present in about 2.5% of routine prostatic needle biopsy specimens. Objective.—To establish the criteria enabling a distinction between ASAP and cancer. Design.—We prospectively evaluated clinical and histologic findings from all 319 patients consecutively diagnosed as

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Jung, Hera, Bo Seong Yun, Yoon Yang Jung, and Hyun-Soo Kim. "Dissecting Gonadoblastoma of the Ovary Coexistent with an Atypical Endometriotic Cyst: Incidental Detection in Cystectomy Specimen of a Woman with 46,XX Karyotype." Diagnostics 12, no. 3 (2022): 660. http://dx.doi.org/10.3390/diagnostics12030660.

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Dissecting gonadoblastoma (DGB) of the ovary, a recently described terminology, defines a unique distribution of neoplastic germ cells. Here, we report a case of incidental DGB coexistent with an atypical endometriotic cyst occurring in a 23-year-old woman. The ovarian cyst was lined by endometrial-like glands and stroma. Some glands displayed nuclear enlargement and hyperchromasia, and abundant eosinophilic cytoplasm with occasional intracytoplasmic hemosiderin and mucin vacuoles. The neoplastic germ cells resembled those of ovarian dysgerminoma and were diffusely distributed within the ovari

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Bhadana, Priyanka, Abha Kiran, Kriti Bhakuni, and Veena G. Malla. "A case of atypical leiomyoma mimicking as endometrial cancer." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 1 (2020): 416. http://dx.doi.org/10.18203/2320-1770.ijrcog20205814.

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Atypical leiomyoma or leiomyoma with bizarre nucleus is diagnosed on histopathological examination characterized by severe cytological atypia in the form of nuclear enlargement, multi nucleation, hyperchromasia, coarse chromatin and prominent nuclei. These tumours do not have typical features of necrosis or mitotic figures to characterize them as leiomyosarcoma. There are 2% risk of these tumours to convert to leiomyosarcoma. 50-year P3L3A1 postmenopausal for past 6 years presented to gynaecology outpatient department (GOPD) with complains of pain in lower abdomen for past 1 year. Patient was

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Asirvatham, Jaya Ruth, Maria Monica Garcia Falcone, and Celina G. Kleer. "Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls." Archives of Pathology & Laboratory Medicine 140, no. 10 (2016): 1045–51. http://dx.doi.org/10.5858/arpa.2016-0238-ra.

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Apocrine change in the breast is an extremely common finding. In most cases, the benign or malignant nature of the lesion is easily recognized. Apocrine adenosis is used to describe sclerosing adenosis with apocrine change. The term apocrine atypia is used when there is significant cytologic atypia in apocrine cells, characterized by a 3-fold nuclear enlargement, prominent/multiple nucleoli, and hyperchromasia. Atypical apocrine adenosis is diagnosed when apocrine adenosis and apocrine atypia are superimposed. However, there are no definite criteria to distinguish atypical apocrine adenosis fr

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Giri, Piyush, Shrinkhala Pokhrel, Pratishtha Pandey, et al. "Rare presentation of Eccrine Porocarcinoma." Journal of Nepal Health Research Council 22, no. 04 (2025): 796–98. https://doi.org/10.33314/jnhrc.v22i04.5038.

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Eccrine porocarcinoma is a tumor of the sweat gland that mostly develops from an existing benign eccrine poroma. It is a rare cutaneous malignancy with a high risk of metastasis and recurrence. Known to affect the elderly population in general with no gender discrepancy, it presents as an ulcerative mass commonly in the trunk or head/neck region. Definitive diagnosis is made by histopathological findings of peculiar pleomorphic cells with nuclear hyperchromasia and mitotic activity, surrounded by ductal lumen. The standard treatment is complete surgical excision with appropriate surgical margi

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Iwai, Sachiko, and Mitsuru Kinjo. "A Combination of Cell Findings Improves the Accuracy of Voided Urine Cytology." Journal of Cytology 41, no. 4 (2024): 183–91. http://dx.doi.org/10.4103/joc.joc_10_24.

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Abstract Introduction: Urine cytology is a morphological diagnostic test that is, patient-friendly and easy to sample but subjective in morphological evaluation. This study aims to evaluate the effect of combining cell findings to assess urine cytology. Materials and Methods: Thirty cell findings found in high-grade urothelial carcinoma (HGUC) were selected for morphological abnormalities, each with detailed definitions. All 66 HGUC and 30 benign cases were examined for morphological abnormalities. The number of cases with at least one abnormal cell finding deviating from normal cells was used

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Liang, He-Shiuan, Tzu-Cheng Hsu, Pong-Jeu Lu, and Fun-In Wang. "TELETHONIN AS AN EARLY IMMUNOHISTOCHEMICAL MARKER IN LIGATION-INDUCED ISCHEMIC MYOCARDIAL INJURY." Taiwan Veterinary Journal 43, no. 04 (2017): 295–306. http://dx.doi.org/10.1142/s1682648517500081.

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In this study, acute myocardial injuries or necrosis were experimentally induced in calves and pigs by ligation of either the left anterior descending coronary artery or left circumflex branch for 30[Formula: see text]min without reperfusion. Various antibodies directed to structural and functional proteins of the sarcomere, as well as activated proteinases, were employed in immunohistochemistry to compare for their potentials to detect early myocardial injury. For comparison, the histological criteria (designated as “Method A”) of cardiomyocyte necrosis such as nuclear pyknosis, sarcoplasmic

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Vörös, Károly, Frauke Seehusen, Stephan Hungerbühler, Andrea Meyer-Lindenberg, and Nina von der Hoeh. "Ventricular Septal Defect with Aortic Valve Insufficiency in a New Zealand White RabbitS." Journal of the American Animal Hospital Association 47, no. 4 (2011): e42-e49. http://dx.doi.org/10.5326/jaaha-ms-5498.

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A heart murmur was detected in a 10 mo old, female New Zealand White rabbit. Auscultation revealed cardiac murmurs both at the left and right hemithorax. Phonocardiography confirmed the systolic–diastolic nature of the left-sided and the systolic character of the right-sided murmur. Electrocardiography showed normal sinus rhythm; tall R waves and large T waves in lead II; and deep S waves in leads II, III, and aVF. Thoracic radiography demonstrated generalized cardiomegaly with prominent pulmonary vasculature. Echocardiography revealed a perimembraneous ventricular septal defect with aortic in

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Potluri, Venkat Sumanth, Ronnie Youssef, Raymond Fertig, and Parneet Dhaliwal. "A Case of ALK-Negative Anaplastic Large Cell Lymphoma Presenting as a Solitary Cutaneous Nodule." SKIN The Journal of Cutaneous Medicine 5, no. 1 (2021): 60–64. http://dx.doi.org/10.25251/skin.5.1.14.

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Anaplastic large cell lymphomas (ALCLs) are a group of CD30 positive T-cell non-Hodgkin lymphomas, accounting for only 3% of all non-Hodgkin lymphomas. As per the 2017 World Health Organization updated classification, there are four variants of ALCL: anaplastic lymphoma kinase (ALK) positive, ALK negative, primary cutaneous, and breast-implant associated. The different variants of ALCL share overlapping clinical presentations and pathologic features, creating a diagnostic challenge. A 71-year-old woman with a past history of T-cell lymphoma presented with a progressively growing nodule on her

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Potluri, Venkat Sumanth, Ronnie Youssef, Raymond Fertig, and Parneet Dhaliwal. "A Case of ALK-Negative Anaplastic Large Cell Lymphoma Presenting as a Solitary Cutaneous Nodule." SKIN The Journal of Cutaneous Medicine 5, no. 1 (2021): 60–64. http://dx.doi.org/10.25251/skin.5.1.14.

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Anaplastic large cell lymphomas (ALCLs) are a group of CD30 positive T-cell non-Hodgkin lymphomas, accounting for only 3% of all non-Hodgkin lymphomas. As per the 2017 World Health Organization updated classification, there are four variants of ALCL: anaplastic lymphoma kinase (ALK) positive, ALK negative, primary cutaneous, and breast-implant associated. The different variants of ALCL share overlapping clinical presentations and pathologic features, creating a diagnostic challenge. A 71-year-old woman with a past history of T-cell lymphoma presented with a progressively growing nodule on her

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Sirikanjanapong, Sasis, Andrew W. Seymour, and Bijal Amin. "Cytologic features of microcystic adnexal carcinoma." CytoJournal 8 (March 3, 2011): 5. http://dx.doi.org/10.4103/1742-6413.77285.

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Microcystic adnexal carcinoma (MAC) is an uncommon skin neoplasm with a predilection location around the lips. It is characterized by cords and nests of neoplastic cells forming ductular or glandular structures that are embedded in dense collagenous stroma. An eighty-seven year old Caucasian female patient presented with a painless, slowly enlarging mass measuring 3.3 × 2.7 × 1.0 cm on the lower lip for approximately 6 months. The patient underwent 2 fine needle aspiration biopsies (FNAs). Smears made from both FNAs demonstrated similar features including low cellular smears, three dimensional

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Iczkowski, Kenneth A. "Current Prostate Biopsy Interpretation: Criteria for Cancer, Atypical Small Acinar Proliferation, High-Grade Prostatic Intraepithelial Neoplasia, and Use of Immunostains." Archives of Pathology & Laboratory Medicine 130, no. 6 (2006): 835–43. http://dx.doi.org/10.5858/2006-130-835-cpbicf.

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Abstract Context.—The past decade has brought major changes in prostate biopsy sampling, interpretation, and reporting. Objective.—To summarize current information on diagnostic decision making, Gleason grading, “atypical” diagnoses, and use of immunostaining. Data Sources.—Pertinent literature from 1985 to 2005 is reviewed, emphasizing recent findings. Conclusions.—Diagnosis begins by evaluating a focus of atypical single-cell layer lined acini according to the 3 minimal diagnostic criteria for cancer: an infiltrative pattern, nuclear enlargement and hyperchromasia, and prominent nucleoli. Th

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Pradhan, Dinesh, and Sambit K. Mohanty. "Uterine Tumors Resembling Ovarian Sex Cord Tumors." Archives of Pathology & Laboratory Medicine 137, no. 12 (2013): 1832–36. http://dx.doi.org/10.5858/arpa.2012-0634-rs.

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Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare neoplasms of unknown etiology. Only 67 cases have been reported in the literature, to our knowledge, so far. The neoplasm usually occurs in middle-aged women. Most patients present with abnormal uterine bleeding and/or abdominal pain, along with an enlarged uterus or a palpable uterine mass. There is no specific imaging finding, and the diagnosis is made exclusively on histopathologic examination. A multitude of architectural patterns are described, which include plexiform cords, anastomosing trabeculae, watered-silk, microfo

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Khan, Amjad Ali, Dr Abdul Shaheed Asghar, Muhammad Ishaq, and Israr Ahmed Akhund. "LOW GRADE UROTHELIAL CARCINOMA." Professional Medical Journal 23, no. 11 (2018): 1323–27. http://dx.doi.org/10.29309/tpmj/2016.23.11.1755.

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Objectives: Urine cytology is an easy to perform non-invasive screening test forpatients who are suspected of having urinary tract malignancy. Urothelial carcinoma constitutesapproximately 90% of all primary tumors of urinary bladder.1 High-grade urothelial carcinomasare represented by well characterized cytological features. Whereas cytological features forlow-grade urothelial carcinomas show considerable overlap with features secondary to chronicinflammation, calculi, indwelling catheters or effects of intra-vesical chemotherapy.2 Thepurpose of this study is to find an appropriate set of cyt

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Thameem A, Sankar Sundaram, and Deepa Sujatha. "Efficacy of categorization of urothelial malignancy in atypical urine samples by the Paris system for reporting urinary cytology." Asian Journal of Medical Sciences 14, no. 5 (2023): 167–72. https://doi.org/10.71152/ajms.v14i5.3732.

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Background: Urine cytology is an important screening tool of patients for urothelial carcinoma and follow-up of patients. Ease of procurement, cost-effectiveness, and lower turnaround time are the advantages. Aims and Objectives: The aim of the study was to identify the accuracy of TPS criteria in diagnosing HGUC, considering biopsy as the gold standard and to describe the cytomorphological features in atypical urine specimens and categorization as per reference to TPS of reporting urine cytology. Definition – Atypical urine sample: Urine samples of patients with macroscopic hematuria and othe

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Thameem A, Sankar Sundaram, and Deepa Sujatha. "Efficacy of categorization of urothelial malignancy in atypical urine samples by the Paris system for reporting urinary cytology." Asian Journal of Medical Sciences 14, no. 5 (2023): 167–72. http://dx.doi.org/10.3126/ajms.v14i5.48836.

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Background: Urine cytology is an important screening tool of patients for urothelial carcinoma and follow-up of patients. Ease of procurement, cost-effectiveness, and lower turnaround time are the advantages. Aims and Objectives: The aim of the study was to identify the accuracy of TPS criteria in diagnosing HGUC, considering biopsy as the gold standard and to describe the cytomorphological features in atypical urine specimens and categorization as per reference to TPS of reporting urine cytology. Definition – Atypical urine sample: Urine samples of patients with macroscopic hematuria and othe

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Monroe, H., and R. El Naili. "DICER1-Mutant Thyroid Carcinoma of Unusual Morphology: A Follicular Carcinoma with Bizarre Nuclei or a Novel Entity?" American Journal of Clinical Pathology 160, Supplement_1 (2023): S57. http://dx.doi.org/10.1093/ajcp/aqad150.128.

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Abstract Introduction/Objective DICER1 mutations are associated with a host of benign and malignant neoplasms, of which the thyroid ranks among those with the highest prevalence. We present a case of a DICER1-mutant thyroid carcinoma with unusual morphologic features not described in the existing literature. Methods/Case Report A 29-year old 33 weeks pregnant female presented with swelling of the left neck. The patient subsequently underwent an ultrasound, which revealed a thyroid lesion measuring 6.2cm in greatest dimension. Labs including TSH and free T4 wree within normal 3rd trimester limi

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Yim, Kwangil, Jung Ha Shin, Jinyoung Yoo, and Stephen Fink. "Novel Pathologic Factors for Risk Stratification of Gastric “Indefinite for Dysplasia” Lesions." Gastroenterology Research and Practice 2020 (September 28, 2020): 1–11. http://dx.doi.org/10.1155/2020/9460681.

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Background/Aims. “Indefinite for dysplasia” (IND) conditions of the stomach have high malignancy rates (22.6%–75.0%). Endoscopic resection is sometimes used for follow-up, but criteria for selecting this follow-up method are not established. We investigated pathologic factors to subclassify the IND of the stomach and select appropriate follow-up methods. Methods. In total, 123 IND cases with final diagnoses of cancer (29.3%), high-grade dysplasia (6.5%), low-grade dysplasia (11.4%), and nonneoplasm (52.8%) were randomly divided into test set ( n = 27 ) and validation set ( n = 96 ). By the ima

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Pop, Romelia, Dragoș Hodor Hodor, Cornel Cătoi Cătoi, Teodora Mocan, Lucian Mocan, and Alexandru-Flaviu Tăbăran. "Correlating Eosin Fluorescence Patterns and Basophilic Alterations in a DEN-Induced HCC Murine Model Through Confocal Microscopy." Cluj Veterinary Journal 29, no. 1 (2024): 16–25. https://doi.org/10.52331/bkynge51.

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: Hepatocellular carcinoma is a major global health concern and a leading cause of cancer-related mortality. The study explores chemically induced murine models, specifically the use of Diethylnitrosamine, to simulate human hepatocellular carcinoma. The focus is on understanding early hepatocellular alterations and distinguishing precursor changes from incidental phenomena. Traditionally, the assessment of hepatocellular alteration foci has relied on hematoxylin and eosin staining. However, this work introduces a novel approach by utilizing the fluorescence properties of eosin, a component of

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Zhang, Rui, Jinlian Liu, Songrui Di, et al. "Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice." Evidence-Based Complementary and Alternative Medicine 2022 (September 8, 2022): 1–8. http://dx.doi.org/10.1155/2022/2781906.

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Background. Oxidative stress and memory impairment have been implicated as common functional brain diseases. Nuclear factor E2-related factor 2 (Nrf2) is highly induced in oxidative stress, indicating that Nrf2 is an emerging target of memory therapy. This study aimed to investigate the effect of noni on brain memory impairment induced by hydrocortisone and its protective mechanism in mice. Methods. Male Kunming mice (n = 8/group) were given hydrocortisone by gastric gavage for 14 consecutive days to establish the memory impairment model, except for those in the control group. On the same day,

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Aly, Salah M., Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, and Aliaa A. Ismail. "Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats." Analytical Cellular Pathology 2019 (October 22, 2019): 1–15. http://dx.doi.org/10.1155/2019/9895485.

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Natural oils are traditional medicinal herbs, which have attracted interests for its potential anti-inflammatory and anticancer activities. The present work is aimed at evaluating the protective effect of garlic oil and cinnamon oil on diethylnitrosamine- (DENA-) and 2-acetylaminofluorene- (2-AAF-) induced p53 gene mutation and hepatocarcinogenesis in rats. Forty male albino rats were divided into 4 equal groups: control, hepatocellular carcinoma (HCC), garlic oil-HCC, and cinnamon oil-HCC. The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the

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Shukla, Prakriti, and Tushar Ojha. "Risk Prediction of Bladder Carcinomas in Atypical Urine Specimens by Redefining Diagnostic Cytomorphological Criteria." Acta Medica International 12, no. 1 (2025): 1–6. https://doi.org/10.4103/amit.amit_92_24.

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Abstract Introduction: Urine cytology in bladder tumors is challenging due to the lack of definite cytomorphological criteria in categorizing atypical cases. The study aims to re-evaluate atypia in the light of three definitive cytological parameters (high N/C ratio, hyperchromasia, and irregular nuclear contours) and correlate with the follow-up histopathology and cytopathology with an attempt to redefine the morphological features that would aid in distinguishing reactive atypia from malignancy. Materials and Methods: A retrospective analysis of 56 atypical urine specimens was performed cons

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Balcı, Mecdi Gürhan, and Mahir Tayfur. "Analysis of breast true-cut biopsies by applying immunohistochemical study of myoepithelial markers." Medical Science and Discovery 6, no. 9 (2019): 173–79. http://dx.doi.org/10.36472/msd.v6i9.288.

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Objective: Breast pathologies are very common in women. Breast cancer is the most common and most frequent cause of death in women. The most common type of breast cancer is invasive ductal carcinoma. Histopathological examination of the tissue taken with a fine needle aspiration biopsy or true-cut biopsy is the main diagnostic method when clinical examination of breast and/ or radiological mass is detected. The definitive diagnosis of benign and malignant lesions of the breast is important in the form of treatment. The most important features in the diagnosis of breast cancer are atypical cell

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Mallepalli, Suresh, Manoj Kumar Gupta, and Ramakrishna Vadde. "Neuroblastoma: An Updated Review on Biology and Treatment." Current Drug Metabolism 20, no. 13 (2020): 1014–22. http://dx.doi.org/10.2174/1389200221666191226102231.

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Background: Neuroblastoma (NB) is the second leading extracranial solid tumors of early childhood and clinically characterized by the presence of round, small, monomorphic cells with excess nuclear pigmentation (hyperchromasia).Owing to a lack of definitive treatment against NB and less survival rate in high-risk patients, there is an urgent requirement to understand molecular mechanisms associated with NB in a better way, which in turn can be utilized for developing drugs towards the treatment of NB in human. Objectives: In this review, an approach was adopted to understand major risk factors

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Kral, Milan, Pavel Zemla, David Hradil, et al. "Iodinated Contrast Medium Affects Urine Cytology Assessment: A Prospective, Single-Blind Study and Its Impact on Urological Practice." Diagnostics 12, no. 10 (2022): 2483. http://dx.doi.org/10.3390/diagnostics12102483.

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During endoscopic procedures for suspected urothelial tumors of the upper urinary tract, radiographic imaging using an iodinated contrast medium is often required. However, following ureteropyelography, we detected changes in cytology characteristics not correlating with real cytology findings in naive urine. The aim of our study was to assess cytology changes between naive and postcontrast urine according to The Paris System of cytology classification. Methods: We prospectively assessed urine samples from 89 patients (23 patients with histologically proven urothelial cancer and 66 healthy vol

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Ristic, Slavica, Mirjana Miric, Sladjana Jovic, Sinisa Ristic, and Jasmina Karic. "Histological characteristics and markers of proliferation and differentiation in rat brain with experimental glioma." Vojnosanitetski pregled 71, no. 9 (2014): 828–32. http://dx.doi.org/10.2298/vsp121016044r.

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Background/Aim. The cell line C6 is a continuous cell line of rat glioma and, as a transplantable line, is frequently used for induction into in vivo model of primary brain tumor. It is believed that, pursuant to its histological traits and biological behavior, this experimental tumor corresponds to human anaplastic astrocytoma of grade II/III, which is characterized by proliferative and invasive potency, and marked cell differentiation. The aim of this study was to determine macroscopic analysis of rat brain with implanted tumor during tumorigenesis, histological features of tumor cells of in

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Geetha, S., F. Mitchell, M. Kashi, P. Ort, and D. Kasturi. "Mammary Carcinoma Metastasizing to Renal Cell Carcinoma: A Case Report." American Journal of Clinical Pathology 162, Supplement_1 (2024): S143. http://dx.doi.org/10.1093/ajcp/aqae129.317.

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Abstract Introduction/Objective The simultaneous occurrence of multiple primary cancers is rare, and even rarer is the phenomenon of one cancer metastasizing to another. Here, we present a case of mammary carcinoma and renal cell carcinoma diagnosed concurrently yet presenting as a cancer-to-cancer metastasis. Methods/Case Report A 79-year-old woman, with a 2-week duration of apnea and cough, was found to have right pleural effusion and underwent thoracocentesis. Cytological examination of the fluid revealed malignant cells suggestive of adenocarcinoma. CT abdomen and chest revealed a 1.6 cm r

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Edem GD, Sakpa CL, and Ezeuko VC. "Premalignant features of the prostate can be ameliorated by Uvaria chamae root extract: Modeling prostate cancer with cadmium and alternative treatment option in adult Wistar rats." Ibom Medical Journal 18, no. 1 (2025): 45–59. https://doi.org/10.61386/imj.v18i1.589.

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Background: Prostate cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths in males worldwide. Mortality attributed with prostate cancer is strongly associated with the age of an individual with relatively higher incidence noticed among aged males. Aim: The present study was carried out to assess the ameliorative effects of Uvaria chamae root extract on cadmium-induced carcinogenic potentials in adult male Wistar rats. Materials and Methods: Sixty (60) adult male rats weighing between 200-210g were used in the current study. They were randomly divided into 10 grou

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Kattoor, Jayasree, and Meherbano M. Kamal. "The gray zone squamous lesions: ASC-US / ASC-H." Cytojournal 19 (April 30, 2022): 30. http://dx.doi.org/10.25259/cmas_03_10_2021.

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The unequivocal and easily recognizable entities of LSIL and HSIL pose no diagnostic problems for a trained eye. However, when the defining morphologic features are either qualitatively or quantitatively insufficient, it is then that the borderline category of “Atypical Squamous cells” (ASC) may have to be used. Scant and suboptimal preparations (mainly in conventional smears) are the common causes that hinder confident decision-making. The binary classification of the ASC category has been retained in The Bethesda System 2014. It includes ASC of undetermined significance (ASC-US) when the aty

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Sheereen, Shazima, Flora Lobo, Barun Kumar, et al. "Histopathological Changes in Breast Cancers Following Neoadjuvant Chemotherapy: Implications for Assessment of Therapy-Induced Cytological and Stromal Changes for Better Clinical Outcome and Effective Patient care." Asian Journal of Oncology 04, no. 02 (2018): 061–68. http://dx.doi.org/10.1055/s-0038-1676909.

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AbstractThe histopathological interpretation of a tumor still remains the gold standard for diagnosis and deciding the type of therapy. Furthermore, in the context of chemo-radio-therapies often leading to prominent cytological and stromal changes in the tumor, histopathological interpretation during treatment, thus, becomes all the more important in correctly diagnosing and grading the tumor for an effective and planned regimen of the therapy increasing prognosis and chances of survival of the affected patients. The aim of the present study was to evaluate such cytological and stromal changes

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Hwang, Soohyun, Hyukjung Kim, Yeong Hak Bang, et al. "Abstract 4659: AI-powered assessment of morphologic likeness to small cell lung cancer (SCLC) predicts progression to SCLC and TKI response in EGFR-mutant NSCLC." Cancer Research 85, no. 8_Supplement_1 (2025): 4659. https://doi.org/10.1158/1538-7445.am2025-4659.

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Abstract Background: A subset of EGFR-mutant non-small cell lung cancers (NSCLC) progresses to small cell lung carcinoma (SCLC) during tyrosine kinase inhibitor (TKI) therapy, particularly in cases with inactivating RB1 mutations. As RB1 mutations are likely foundational events in SCLC transformation, we hypothesize that tumors susceptible to this transformation exhibit morphologic features resembling SCLC even at the time of the initial diagnostic biopsy. Methods: We developed a predictive model for identifying the SCLC phenotype using H&E-stained slides from cases with confirmed SCLC his

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Abdulghani, Mohanad Mundher, Mohamad Natiq Abbas, and Wafaa Redha Mohammed. "Immunohistochemical Expression of Epidermal Growth Factor Receptor in Astrocytic Tumors in Iraqi Patients." Open Access Macedonian Journal of Medical Sciences 7, no. 21 (2019): 3514–20. http://dx.doi.org/10.3889/oamjms.2019.751.

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BACKGROUND: Diffuse astrocytomas constitute the largest group of primary malignant human intracranial tumours. They are classified by the World Health Organization (WHO) into three histological malignancy grades: diffuse astrocytomas (grade II), anaplastic astrocytomas (grade III) and glioblastoma (grade IV) based on histopathological features such as cellular atypia, mitotic activity, necrosis and microvascular proliferation. Epidermal growth factor receptor (EGFR) is a 170-kDa transmembrane tyrosine kinase receptor expressed in a variety of normal and malignant cells regulating critical cell

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Kullukçu, Hümeyra. "Endocan; a Novel Inflammatory Indicator for Spinal Trauma? an Experimental Study in Rats." New Medical Innovations and Research 4, no. 5 (2023): 01–06. https://doi.org/10.31579/2767-7370/058.

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Aim: The prognosis of spinal cord injuries is determined through the use of various inflammatory markers and scoring systems. In this study, it was aimed to investigate the relationship between trauma severity and serum endothelial cell-specific molecule 1 (ESM-1; Endocan) levels, a novel inflammatory marker, in an experimental spinal cord trauma model in rats. Materials and Methods: Sixteen adult male Sprague-Dawley rats were assigned to 2 groups: control (Group 1) and trauma (Group 2). The spinal cord injury was induced by a modified Allen's weight-drop technique. Tail blood was collected fr

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Omar, Mohamed, David Kim, Luigi Marchionni, and Momin T. Siddiqui. "Abstract 5414: Automated detection of high-grade urothelial carcinoma from urine cytology slides using attention-based deep learning." Cancer Research 83, no. 7_Supplement (2023): 5414. http://dx.doi.org/10.1158/1538-7445.am2023-5414.

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Abstract Urine cytology has long been an effective and non-invasive test for the detection of bladder urothelial carcinomas (UC) routinely performed in cases of unexplained hematuria or for monitoring patients with UC. In cytopathology practice, urine cytology specimens are examined manually with a light microscope to identify morphologic features associated with different diagnostic categories based on the Paris System (TPS) for Reporting Urinary Cytology. Specifically, the diagnosis of high-grade urothelial carcinoma (HGUC) requires the identification of &gt; 5-10 cells with a nuclear/cy

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Xu, Mingjing, Yin Kau Lam, Jianqing Yu, Kelvin Kwok Chai Ng, and Nathalie Wong. "Abstract 2590: TP53 R249S mutation confers hepatic organoids with gain-of-function (GOF) tumorigenic features through transcriptional activation of ZMIZ2." Cancer Research 83, no. 7_Supplement (2023): 2590. http://dx.doi.org/10.1158/1538-7445.am2023-2590.

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Abstract Hepatocellular Carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide. TP53 mutations are pivotal genomic drivers for HCC development through frequent concurrent loss-of-function (LOF) aberrations and protein-altering missense mutations. Over 90% of the TP53 missense mutations are distributed within the core DNA binding domain (DBD), where R249S is the most common. Cumulative studies have demonstrated the cancer-promoting properties of TP53R249S mutation in HCC, but its biological impact on tumor initiation remains to be defined. To mimic the early st

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McNutt, N. S., R. M. Levenson, and S. B. Peters. "Spectral Imaging Microscopy Reveals Nuclear Eosinophilia in Hyperchromatic Nuclei of Mycosis Fungoides and Other Disorders." American Journal of Dermatopathology 27, no. 6 (2005): 532. http://dx.doi.org/10.1097/01.dad.0000197730.79791.3c.

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