Academic literature on the topic 'Nucleic acid'

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Journal articles on the topic "Nucleic acid"

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Yildirim, Asil, Brad Varner, Monika Sharma, Liang Fang, and Michael Feig. "2P120 Conformational Sampling of Nucleic Acids in Cellular Environments(05A. Nucleic acid: Structure & Property,Poster)." Seibutsu Butsuri 53, supplement1-2 (2013): S178. http://dx.doi.org/10.2142/biophys.53.s178_6.

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Bergen, Jamie M., and Suzie H. Pun. "Peptide-Enhanced Nucleic Acid Delivery." MRS Bulletin 30, no. 9 (September 2005): 663–67. http://dx.doi.org/10.1557/mrs2005.194.

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AbstractNumerous barriers, both extracellular and intracellular, hinder successful and efficient nonviral nucleic acid delivery. Due to their small size and ability to specifically recognize and interact with molecular targets, peptides can be incorporated as modular elements into synthetic nucleic acid delivery systems to overcome many of these barriers. Three classes of peptides that have frequently been integrated as components in nucleic acid delivery systems include cell-penetrating peptides (CPPs), endosomal release peptides, and nuclear localization sequences (NLSs).Various additional classes of peptides show promise for enhancing nucleic acid delivery by targeting cell surface receptors, inhibiting nuclease activity, and directing nucleic acids toward intracellular targets. In addition to a review of the various existing approaches to peptide-enhanced nucleic acid delivery, this article will discuss strategies for the development of new peptides and approaches for the incorporation of these peptides into nucleic acid delivery systems.
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Stoddard, Barry L., Anastasia Khvorova, David R. Corey, William S. Dynan, and Keith R. Fox. "Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics." Nucleic Acids Research 46, no. 4 (February 23, 2018): 1563–64. http://dx.doi.org/10.1093/nar/gky059.

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Reece, Richard. "The messenger: the structure of RNA." Biochemist 28, no. 2 (April 1, 2006): 33–35. http://dx.doi.org/10.1042/bio02802033.

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In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1. Chemical tests by Miescher showed that nuclein contained large amounts of phosphorus and no sulphur, characteristics that differentiated it from proteins1. The first step in determining the structure of nucleic acid (either DNA or RNA) would be to identify its precise composition. RNA was considered a more approachable target for composition analysis because the simple treatment of RNA with hydroxide rapidly and completely hydrolyses the molecule to its individual component nucleotides. DNA, on the other hand, is resistant to such treatment.
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Zhou, Ding, Guy Schepers, and Arthur Van Aerschot. "A Simple Nucleic Acid Alternative: Aminopropyl Nucleic Acids (APNAs)." Nucleosides, Nucleotides and Nucleic Acids 26, no. 10-12 (November 26, 2007): 1665–68. http://dx.doi.org/10.1080/15257770701493625.

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Berman, Helen M., John Westbrook, Zukang Feng, Lisa Iype, Bohdan Schneider, and Christine Zardecki. "The Nucleic Acid Database." Acta Crystallographica Section D Biological Crystallography 58, no. 6 (May 29, 2002): 889–98. http://dx.doi.org/10.1107/s0907444902003487.

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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures. The architecture and capabilities of the Nucleic Acid Database, as well as some of the research enabled by this resource, are presented in this article.
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Heras, Sara R., M. Carmen Thomas, Francisco Macias, Manuel E. Patarroyo, Carlos Alonso, and Manuel C. López. "Nucleic-acid-binding properties of the C2-L1Tc nucleic acid chaperone encoded by L1Tc retrotransposon." Biochemical Journal 424, no. 3 (December 10, 2009): 479–90. http://dx.doi.org/10.1042/bj20090766.

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It has been reported previously that the C2-L1Tc protein located in the Trypanosoma cruzi LINE (long interspersed nuclear element) L1Tc 3′ terminal end has NAC (nucleic acid chaperone) activity, an essential activity for retrotransposition of LINE-1. The C2-L1Tc protein contains two cysteine motifs of a C2H2 type, similar to those present in TFIIIA (transcription factor IIIA). The cysteine motifs are flanked by positively charged amino acid regions. The results of the present study show that the C2-L1Tc recombinant protein has at least a 16-fold higher affinity for single-stranded than for double-stranded nucleic acids, and that it exhibits a clear preference for RNA binding over DNA. The C2-L1Tc binding profile (to RNA and DNA) corresponds to a non-co-operative-binding model. The zinc fingers present in C2-L1Tc have a different binding affinity to nucleic acid molecules and also different NAC activity. The RRR and RRRKEK [NLS (nuclear localization sequence)] sequences, as well as the C2H2 zinc finger located immediately downstream of these basic stretches are the main motifs responsible for the strong affinity of C2-L1Tc to RNA. These domains also contribute to bind single- and double-stranded DNA and have a duplex-stabilizing effect. However, the peptide containing the zinc finger situated towards the C-terminal end of C2-L1Tc protein has a slight destabilization effect on a mismatched DNA duplex and shows a strong preference for single-stranded nucleic acids, such as C2-L1Tc. These results provide further insight into the essential properties of the C2-L1Tc protein as a NAC.
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Bartas, Martin, Jiří Červeň, Simona Guziurová, Kristyna Slychko, and Petr Pečinka. "Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins." International Journal of Molecular Sciences 22, no. 2 (January 18, 2021): 922. http://dx.doi.org/10.3390/ijms22020922.

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Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome because a large proportion of proteins can bind both DNA and RNA. Another even more important features of nucleic acid-binding proteins are so-called sequence or structure specificities. Proteins able to bind nucleic acids in a sequence-specific manner usually contain one or more of the well-defined structural motifs (zinc-fingers, leucine zipper, helix-turn-helix, or helix-loop-helix). In contrast, many proteins do not recognize nucleic acid sequence but rather local DNA or RNA structures (G-quadruplexes, i-motifs, triplexes, cruciforms, left-handed DNA/RNA form, and others). Finally, there are also proteins recognizing both sequence and local structural properties of nucleic acids (e.g., famous tumor suppressor p53). In this mini-review, we aim to summarize current knowledge about the amino acid composition of various types of nucleic acid-binding proteins with a special focus on significant enrichment and/or depletion in each category.
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Cai, Xiaomeng, Rui Dou, Chen Guo, Jiaruo Tang, Xiajuan Li, Jun Chen, and Jiayu Zhang. "Cationic Polymers as Transfection Reagents for Nucleic Acid Delivery." Pharmaceutics 15, no. 5 (May 15, 2023): 1502. http://dx.doi.org/10.3390/pharmaceutics15051502.

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Nucleic acid therapy can achieve lasting and even curative effects through gene augmentation, gene suppression, and genome editing. However, it is difficult for naked nucleic acid molecules to enter cells. As a result, the key to nucleic acid therapy is the introduction of nucleic acid molecules into cells. Cationic polymers are non-viral nucleic acid delivery systems with positively charged groups on their molecules that concentrate nucleic acid molecules to form nanoparticles, which help nucleic acids cross barriers to express proteins in cells or inhibit target gene expression. Cationic polymers are easy to synthesize, modify, and structurally control, making them a promising class of nucleic acid delivery systems. In this manuscript, we describe several representative cationic polymers, especially biodegradable cationic polymers, and provide an outlook on cationic polymers as nucleic acid delivery vehicles.
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Huang, Zhen, Andrey Kovalevsky, Qianwei Zhao, and Lillian Hu. "Nucleic acid protein crystallography facilitated by selenium nucleic acids (SeNA)." Acta Crystallographica Section A Foundations and Advances 75, a1 (July 20, 2019): a158. http://dx.doi.org/10.1107/s0108767319098428.

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Dissertations / Theses on the topic "Nucleic acid"

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Pérez, González Daniel Cibrán. "Single-molecule studies of nucleic acid folding and nucleic acid-protein interactions." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/12039.

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Nucleic acids and proteins, some of the building blocks of life, are not static structures but highly dynamic entities that need to interact with one another to meet cellular demands. The work presented in this thesis focuses on the application of highly sensitive fluorescence methods, both at ensemble and single-molecule level, to determine the dynamics and structure of specific biomolecular interactions with nanometer resolution and in temporal scales from nanoseconds to minutes, which includes most biologically relevant processes. The main aims of my PhD can be classified in three areas: i) exploring new fluorescent sensors with increased specificity for certain nucleic acid structures; ii) understanding how some of these nucleic acids sense the presence of small molecules in the cellular environment and trigger gene regulation by altering their structure; and iii) understanding how certain molecular machines, such as helicase proteins, are able to unwind the DNA double helix by using chemical energy in the form of ATP hydrolysis.
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Xia, Xin. "Bifacial Peptide Nucleic Acid (bPNA) as a Regulator of Nucleic Acid Function." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437506395.

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Murray, Euan. "Synthesis of peptide nucleic acid-functionalised polydiacetylene liposomes for use as nucleic acid biosensors." Thesis, Heriot-Watt University, 2004. http://hdl.handle.net/10399/356.

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Kasper, Julia Christina. "Lyophilization of nucleic acid nanoparticles." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-144256.

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Akhras, Michael S. "Nucleic Acid Based Pathogen Diagnostics." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4684.

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Pathogenic organisms are transmitted to the host organism through all possible connected pathways, and cause a myriad of diseases states. Commonly occurring curable infectious diseases still impose the greatest health impacts on a worldwide perspective. The Bill & Melinda Gates Foundation partnered with RAND Corporation to form the Global Health Diagnostics Forum, with the goal of establishing and interpreting mathematical models for what effects a newly introduced point-of-care pathogen diagnostic would have in developing countries. The results were astonishing, with potentially millions of lives to be saved on an annual basis. Golden standard for diagnostics of pathogenic bacteria has long been cultureable medias. Environmental biologists have estimated that less than 1% of all bacteria are cultureable. Genomic-based approaches offer the potential to identify all microbes from all the biological kingdoms. Nucleic acid based pathogen diagnostics has evolved significantly over the past decades. Novel technologies offer increased potential in sensitivity, specificity, decreased costs and parallel sample management. However, most methods are confined to core laboratory facilities. To construct an ultimate nucleic acid based diagnostic for use in areas of need, potential frontline techniques need to be identified and combined. The research focus of this doctoral thesis work has been to develop and apply nucleic acid based methods for pathogen diagnostics. Methods and assays were applied to the two distinct systems i) screening for antibiotic resistance mutations in the bacterial pathogen Neisseria gonorrhoeae, and ii) genotype determination of the cancer causative Human Papillomavirus (HPV). The first part of the study included development of rapid, direct and multiplex Pyrosequencing nucleic acid screenings. With improved methodology in the sample preparation process, we could detect an existence of multiple co-infecting HPV genotypes at greater sensitivities than previously described, when using the same type of methodology. The second part of the study focused on multiplex nucleic acid amplification strategies using Molecular Inversion Probes with end-step Pyrosequencing screening. The PathogenMip assay presents a complete detection schematic for virtually any known pathogenic organism. We also introduce the novel Connector Inversion Probe, a padlock probe capable of complete gap-fill reactions for multiplex nucleic acid amplifications.
Patogena organismer smittas till värd organismen genom alla möjliga kontaktnätverk och skapar en mångfald olika sjukdomstillstånd. Dock är det fortfarande vanligt förekommande behandlingsbara infektiösa sjukdomar som orsakar den största hälsoförlusten, sett från ett globalt perspektiv. Bill och Melinda Gates Stiftelsen samarbetade med RAND kooperation för att forma “The Global Health Diagnostics Forum”. Deras mål var att etablera och analysera matematiska modeller för vilka effekter en ny diagnostisk metod utrustat för fältarbete skulle ha i utvecklingsländer. Resultaten var häpnadsveckande, med potentiellt miljoner av liv som skulle kunna räddas på en årlig basis. Den etablerade standarden för diagnostik av patogena bakterier har länge varit kultiveringsmedia baserad. Miljö specialiserade biologer har estimerat att mindre än 1 % av alla bakterie arter går att kultivera. Dock erbjuder genetiska analyser potentialen att kunna identifiera alla mikrober från alla de biologiska rikena. Nukleinsyrebaserade diagnostiska metoder har märkbart förbättrats över de senaste årtionden. Nya tekniker erbjuder utökad sensitivitet, selektivitet, sänkta kostnader och parallella analyser av patient prover. Dock är de flesta metoderna begränsade till standardiserade laboratoriemiljöer. För att konstruera en väl fungerande diagnostisk fältutrustning för användning i problem områden, behöver världsledande tekniker identifieras och kombineras. Fokuseringsområdet för denna doktorsavhandling har varit att utveckla och utföra nukleinsyrebaserade metoder för patogen diagnostik. Metoder och experimentella utförande applicerades på två distinkta system i) sökning av antibiotika resistens relaterade mutationer i den patogena bakterien Neisseria gonorrhoeae och ii) genotypning av det cancer orsakande Humana Papillomaviruset (HPV). Den första delen av studien inriktade sig mot utveckling av snabba, direkta och multiplexa Pyrosekvenserings baserade nukleinsyreanalyser. Med förbättrad provprepareringsmetodologi kunde vi detektera multipla HPV infektioner med högre sensitivitet än vad tidigare beskrivits med liknande metodologi. Den andra delen av studien fokuserades på multiplexa nukleinsyre amplifikationer med “Molecular Inversion Probe” tekniken med sista steg Pyrosekvenserings analys. “PathogenMip assay” erbjuder ett komplett detektionsprotokoll för alla kända patogena organismer. Vi introducerar även den nya “Connector Inversion Probe”, en “Padlock Probe” kapabel att genomföra kompletta gap fyllningar för multiplex nukleinsyre amplifiering.
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Elmén, Joacim. "Nucleic acid based therapeutic approaches /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-047-8/.

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Horsey, Imogen. "Studies on nucleic acid recognition." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621617.

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Shim, Min Suk. "Molecularly Engineered Acid-Responsive Polymers for Nucleic Acid Delivery." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291412851.

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O'Meara, Deirdre. "Molecular Tools for Nucleic Acid Analysis." Doctoral thesis, Stockholm : Tekniska högsk, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3220.

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Chatwell, Nicola. "Nucleic acid approaches to toxin detection." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606582.

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PCR is commonly used for detecting contamination of foods by toxigenic bacteria. However, it is unknown whether it is suitable for detecting toxins in samples which are unlikely to contain bacterial cells, such as purified biological weapons. Quantitative real-time PCR assays were developed for amplification of the genes encoding Clostridium botulinum neurotoxins A to F, Staphylococcal enteroxin B (SEB), ricin, and C. perfringens alpha toxin. Botulinum neurotoxins, alpha toxin, ricin and V antigen from Yersinia pestis were purified at Dstl using methods including precipitation, ion exchange, FPLC, affinity chromatography and gel filtration. Additionally, toxin samples of unknown purity were purchased from a commercial supplier. Q-PCR analysis showed that DNA was present in crudely prepared toxin samples. However, the majority of purified or commercially produced toxins were not detectable by PCR. Therefore, it is unlikely that PCR will serve as a primary toxin detection method in future. Immuno-PCR was investigated as an alternative, more direct method of toxin detection. Several iterations of the method were investigated, each using a different way of labelling the secondary antibody with DNA. It was discovered that the way in which antibodies are labelled with DNA is crucial to the success of the method, as the DNA concentration must be optimised in order to fully take advantage of signal amplification without causing excessive background noise. In general terms immuno-PCR was demonstrated to offer increased sensitivity over conventional ELISA, once fully optimised, making it particularly useful for biological weapons analysis.
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Books on the topic "Nucleic acid"

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1943-, Ross J., ed. Nucleic acid hybridization. Chichester: Wiley, 1998.

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Stephen, Neidle, ed. Nucleic acid structure. New York, N.Y., (USA): VCH Publishers, 1987.

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Mayer, Günter, and Marcus M. Menger, eds. Nucleic Acid Aptamers. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2695-5.

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Kjems, Jørgen, Elena Ferapontova, and Kurt V. Gothelf, eds. Nucleic Acid Nanotechnology. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-38815-6.

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Kolpashchikov, Dmitry M., and Yulia V. Gerasimova, eds. Nucleic Acid Detection. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-535-4.

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Tietz, Dietmar, ed. Nucleic Acid Electrophoresis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58924-9.

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Murakami, Katsuhiko S., and Michael A. Trakselis, eds. Nucleic Acid Polymerases. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-39796-7.

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Ennifar, Eric, ed. Nucleic Acid Crystallography. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2763-0.

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Mayer, Günter, ed. Nucleic Acid Aptamers. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3197-2.

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Murakami, Akira, ed. Nucleic Acid Drugs. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30463-7.

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Book chapters on the topic "Nucleic acid"

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Capinera, John L., Marjorie A. Hoy, Paul W. Paré, Mohamed A. Farag, John T. Trumble, Murray B. Isman, Byron J. Adams, et al. "Nucleic Acid." In Encyclopedia of Entomology, 2622. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_2262.

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Gooch, Jan W. "Nucleic Acid." In Encyclopedic Dictionary of Polymers, 492. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8023.

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Nakamura, Yoshikazu. "Aptamer: Biology to Applications." In Nucleic Acid Drugs, 135–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_128.

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Lee, Yan, and Kazunori Kataoka. "Delivery of Nucleic Acid Drugs." In Nucleic Acid Drugs, 95–134. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_129.

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Yano, Junichi, and Gerald E. Smyth. "New Antisense Strategies: Chemical Synthesis of RNA Oligomers." In Nucleic Acid Drugs, 1–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_136.

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Kandimalla, Ekambar R., and Sudhir Agrawal. "Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides." In Nucleic Acid Drugs, 61–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_138.

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Osako, Mariana Kiomy, Hironori Nakagami, and Ryuichi Morishita. "Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application." In Nucleic Acid Drugs, 49–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_139.

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Aishwarya, Veenu, Anna Kalota, and Alan M. Gewirtz. "Development and Clinical Applications of Nucleic Acid Therapeutics." In Nucleic Acid Drugs, 153–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_146.

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Stellwagen, Nancy C. "DNA Gel Electrophoresis." In Nucleic Acid Electrophoresis, 1–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58924-9_1.

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Fried, Michael G., and Mark M. Garner. "The Electrophoretic Mobility Shift Assay (EMSA) for Detection and Analysis of Protein-DNA Interactions." In Nucleic Acid Electrophoresis, 239–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58924-9_10.

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Conference papers on the topic "Nucleic acid"

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Satish, D. "Ionization Potentials of Nucleic Acid Intercalators." In Functional Materials and Applied Physics. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644901878-12.

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Abstract. Nucleic acid based electronic devices have attracted particular interest over the past two decades due to its ability of long-range charge transport and self-assembly. The π-π interactions of the stacked bases are believed to be responsible for the long-range charge transport. The insertion of intercalators could alter electronic structure of the host nucleic acids which may influence the charge transport through the nucleic acid. The influence of intercalators on charge transport through the host nucleic acids largely depends on ionization potentials of the intercalators. Therefore, in this work we intend to determine vertical and adiabatic ionization potentials of the nucleic acid intercalators by using density functional theory calculations using Gaussian 16 package. We also explore the role of solvent and discuss the significance of ionization potential values in comparison with the ionization potential values of nucleic acid bases. Ionization Potential values of these intercalators range from 7.67 eV to 11.12 eV and 4.5 eV to 6.46 eV in vacuum and aqueous medium, respectively. Daunomycin is found to have lowest ionization potential value in vacuum as well as in aqueous medium. On the other hand, Proflavine (Anthraquinone) has highest ionization potential value in vacuum (aqueous medium). Non-planar intercalators exhibit distinct vertical and adiabatic ionization potential values and decrease drastically upon solvation.
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Benett, William J., James B. Richards, Paul Stratton, Dean R. Hadley, Brian H. Bodtker, Shanavaz L. Nasarabadi, Fred P. Milanovich, Raymond P. Mariella, Jr., Ronald P. Koopman, and Philip Belgrader. "Handheld advanced nucleic acid analyzer." In Environmental and Industrial Sensing, edited by Robert A. Lieberman. SPIE, 2000. http://dx.doi.org/10.1117/12.411712.

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Pinkel, D., J. Gray, R. Segraves, F. Waldman, B. Trask, L. C. Yu, D. Eastmond, and P. Dean. "Fluorescent Nucleic Acid Hybridization Methods." In OE/LASE '89, edited by Gary C. Salzman. SPIE, 1989. http://dx.doi.org/10.1117/12.951898.

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Cai*, Yushan. "Nanoparticle based nucleic acid vaccines." In Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), edited by Alan Wang. SPIE, 2024. http://dx.doi.org/10.1117/12.3012824.

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Belov, D. A., Yu V. Belov, A. L. Zolkin, M. G. Grigoriev, and A. K. Rakymzhan. "Nucleic acid melting signals processing." In PROCEEDINGS OF THE II INTERNATIONAL SCIENTIFIC CONFERENCE ON ADVANCES IN SCIENCE, ENGINEERING AND DIGITAL EDUCATION: (ASEDU-II 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0104175.

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Lin, Zhihong, Meng Wu, Shu Ren, Michaela Arbter, Martin Boehmer, Vladimir Mirsky, and Otto S. Wolfbeis. "Single- and dual- near-infrared fluorescent labeled nucleic acid conjugate for nucleic acid detection." In International Conference on Sensing units and Sensor Technology, edited by Yikai Zhou and Shunqing Xu. SPIE, 2001. http://dx.doi.org/10.1117/12.440165.

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Robins, Morris J. "Transformation chemistry with nucleic acid purines." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810028.

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Krishnamoorthy, G. "Fluorescence window reveals nucleic acid dynamics." In International Conference on Fibre Optics and Photonics. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/photonics.2016.tu2b.2.

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Jung, Paul M., Hsiang-Yun Hu, and Omar S. Khalil. "Energy transfer of nucleic acid products." In Photonics West '95, edited by Gerald E. Cohn, Jeremy M. Lerner, Kevin J. Liddane, Alexander Scheeline, and Steven A. Soper. SPIE, 1995. http://dx.doi.org/10.1117/12.206013.

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Weigl, Bernhard H., Gonzalo Domingo, Jay Gerlach, Dennis Tang, Darrel Harvey, Nick Talwar, Alex Fichtenholz, Bill van Lew, and Paul LaBarre. "Non-instrumented nucleic acid amplification assay." In MOEMS-MEMS 2008 Micro and Nanofabrication, edited by Wanjun Wang and Claude Vauchier. SPIE, 2008. http://dx.doi.org/10.1117/12.763650.

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Reports on the topic "Nucleic acid"

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Berube, Paul M., Scott M. Gifford, Bonnie Hurwitz, Bethany Jenkins, Adrian Marchetti, and Alyson E. Santoro. Roadmap Towards Communitywide Intercalibration and Standardization of Ocean Nucleic Acids ‘Omics Measurements. Woods Hole Oceanographic Institution, March 2022. http://dx.doi.org/10.1575/1912/28054.

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In January 2020, the US Ocean Carbon & Biogeochemistry (OCB) Project Office funded the Ocean Nucleic Acids 'omics Intercalibration and Standardization workshop held at the University of North Carolina in Chapel Hill. Thirty-two participants from across the US, along with guests from Canada and France, met to develop a framework for standardization and intercalibration (S&I) of ocean nucleic acid ‘omics (na’omics) approaches (i.e., amplicon sequencing, metagenomics and metatranscriptomics). During the three-day workshop, participants discussed numerous topics, including: a) sample biomass collection and nucleic acid preservation for downstream analysis, b) extraction protocols for nucleic acids, c) addition of standard reference material to nucleic acid isolation protocols, d) isolation methods unique to RNA, e) sequence library construction, and f ) integration of bioinformatic considerations. This report provides a summary of these and other topics covered during the workshop and a series of recommendations for future S&I activities for na’omics approaches.
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States, David J. Analysis and Annotation of Nucleic Acid Sequence. Office of Scientific and Technical Information (OSTI), July 2004. http://dx.doi.org/10.2172/899629.

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David J. States. Analysis and Annotation of Nucleic Acid Sequence. Office of Scientific and Technical Information (OSTI), August 1998. http://dx.doi.org/10.2172/826380.

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Kraus, G., and M. Nilsen-Hamilton. Developing Aptamers to Methaphetamine as Nucleic Acid Sensors. Office of Scientific and Technical Information (OSTI), December 2005. http://dx.doi.org/10.2172/882988.

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Chen, Winston Chung-Hsuan. Rapid Nucleic Acid Analysis for Contaminant Impact Evaluation. Office of Scientific and Technical Information (OSTI), May 2001. http://dx.doi.org/10.2172/839370.

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Chen, Winston C. H. Rapid Nucleic Acid Analysis for Contaminant Impact Evaluation. Office of Scientific and Technical Information (OSTI), June 2002. http://dx.doi.org/10.2172/839372.

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Silver, Pamela A. Genome-Wide Nucleic Acid/Protein Interaction in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2005. http://dx.doi.org/10.21236/ada435620.

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Castro, A., and E. B. Shera. Ultrasensitive nucleic acid sequence detection by single-molecule electrophoresis. Office of Scientific and Technical Information (OSTI), September 1996. http://dx.doi.org/10.2172/374265.

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Silver, Pamela A. Genome-Wide Nucleic Acid/Protein Interaction in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada426138.

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Silver, Pamela A. Genome-Wide Nucleic Acid/Protein Interactions in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada416691.

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