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1

Methods for studying nucleic acid/drug interactions. Boca Raton: Taylor & Francis, 2012.

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2

Pullman, Bernard, and Joshua Jortner, eds. Molecular Basis of Specificity in Nucleic Acid-Drug Interactions. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3728-7.

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3

Therapeutic applications of quadruplex nucleic acids. London: Elsevier/Academic Press, 2012.

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4

Neidle, Stephen. Therapeutic applications of quadruplex nucleic acids. London: Elsevier/Academic Press, 2012.

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5

Murakami, Akira, ed. Nucleic Acid Drugs. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-30463-7.

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6

New York Academy of Sciences. Pharmaceutical science to improve the human condition: Prix Galien 2010 : winners and finalist candidates of the Prix Galien USA, International, and Pro Bono Humanitarian Awards 2010. Malden, MA: Wiley Periodicals, 2011.

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7

Jerusalem Symposium on Quantum Chemistry and Biochemistry (23rd 1990). Molecular basis of specificity in nucleic acid-drug interactions: Proceedings of the Twenty-third Jerusalem Symposium on Quantum Chemistry and Biochemistry, held in Jerusalem, Israel, May 14-17, 1990. Dordrecht: Kluwer Academic Publishers, 1990.

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8

Zhong yao cai sheng wu duo yang xing ji he suan fen xi ji shu. Beijing: Ke xue chu ban she, 2009.

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9

Spada, Stefania. Directory of approved biopharmaceutical products. Boca Raton: CRC Press, 2005.

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10

service), SpringerLink (Online, ed. The Nucleolus. New York, NY: Springer Science+Business Media, LLC, 2011.

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11

1946-, Propst C. L., and Perun Thomas J, eds. Nucleic acid targeted drug design. New York: M. Dekker, 1992.

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12

Gewirtz, Alan M. Nucleic Acid Therapeutics in Cancer (Cancer Drug Discovery and Development). Humana Press, 2004.

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13

Nanotechnology For Nucleic Acid Delivery Methods And Protocols. Humana Press, 2012.

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14

(Editor), Jonathan B. Chaires, and Michael J. Waring (Editor), eds. Drug-Nucleic Acid Interactions (Methods in Enzymology, Volume 340) (Methods in Enzymology). Academic Press, 2001.

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15

M, Demeunynck, Bailly Christian, and Wilson W. D, eds. Small molecule DNA and RNA binders: From synthesis to nucleic acid complexes. Weinheim: Wiley-VCH, 2003.

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16

Eric, Wickstrom, ed. Prospects for antisense nucleic acid therapy of cancer and AIDS. New York: Wiley-Liss, 1991.

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17

Murakami, Akira. Nucleic Acid Drugs. Springer, 2014.

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18

Nucleic Acid Drugs. Springer, 2012.

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19

Pullman, A., and Joshua Jortner. Molecular Basis of Specificity in Nucleic Acid-Drug Interactions: Proceedings of the Twenty-Third Jerusalem Symposium on Quantum Chemistry and ... May 14–17, 1990. Springer, 2012.

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20

Leong, Terence T. Thermodynamics of nucleic acids ; and, Nucleic acid interactions with CC1065 and structurally analogous cytotoxic drugs. 1989.

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21

Ryutaro, Utsumi, ed. Bacterial signal transduction: Networks and drug targets. New York: Springer Science+Business Media, 2008.

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22

Nucleic Acids as Gene Anticancer Drug Delivery Therapy. Elsevier, 2019. http://dx.doi.org/10.1016/c2019-0-00456-6.

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23

T, Crooke Stanley, ed. Antisense drug technology: Principles, strategies, and applications. 2nd ed. Boca Raton: Taylor & Francis, 2006.

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24

I, Mahato Ram, ed. Biomaterials for delivery and targeting of proteins and nucleic acids. Boca Raton: CRC Press, 2005.

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25

Torsten, Schwede, and Peitsch Manuel C, eds. Computational structural biology: Methods and applications. Hackensack, N.J: World Scientific, 2008.

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26

Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. CRC, 2004.

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27

Lene, Jorgensen, and Nielsen Hanne Mørck, eds. Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids, and vaccines. Chichester, West Sussex: John Wiley, 2009.

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28

Ferrari, Nicolay, and Rosanne Seguin. Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development. Wiley & Sons, Incorporated, John, 2018.

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29

Ferrari, Nicolay, and Rosanne Seguin. Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development. Wiley & Sons, Incorporated, John, 2018.

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30

Crooke, Stanley T. Antisense Drug Technology: Principles, Strategies, and Applications. CRC, 2001.

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31

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids. Elsevier Science & Technology, 2017.

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32

Crooke, Stanley T. Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition. 2nd ed. CRC, 2007.

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33

Bhat, Irshad Ul Haq, and Zakia Khanam. Nucleic Acids: A Natural Target for Newly Designed Metal Chelate-Based Drugs. Elsevier Science & Technology Books, 2020.

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34

Tang, Choon Kit, and Ken Ishii. Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology. Elsevier Science & Technology, 2016.

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35

Tang, Choon Kit, and Ken J. Ishii. Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology. Elsevier Science & Technology Books, 2013.

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36

Borchardt, Ronald T., Cyrus R. Creveling, and Per Magne Ueland. Biological Methylation and Drug Design: Experimental and Clinical Role of S-Adenosylmethionine. Humana, 2011.

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37

T, Borchardt Ronald, Creveling Cyrus R, and Ueland Per Magne, eds. Biological methylation and drug design: Experimental and clinical role of S-adenosylmethionine. Clifton, N.J: Humana Press, 1986.

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38

Biological Methylation and Drug Design: Experimental and Clinical Role of S-Adenosylmethionine. Humana Press, 2011.

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39

Spada, Stefania, and Gary Walsh. Directory of Approved Biopharmaceutical Products (Pharmaceutical Science). CRC, 2004.

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40

Borchardt, Ronald T., Cyrus R. Creveling, and Per Magne Ueland. Biological Methylation and Drug Design: Experimental and Clinical Roles of S-Adenosylmethionine (Experimental Biology and Medicine). Humana Press, 1986.

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41

(Editor), Robert B. Raffa, and Frank Porreca (Editor), eds. Antisense Strategies for the Study of Receptor Mechanisms (Neuroscience Intelligence Unit). Landes Bioscience, 1996.

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42

(Editor), Martine Demeunynck, Christian Bailly (Editor), and W. David Wilson (Editor), eds. DNA and RNA Binders, From Small Molecules to Drugs (2-Volume Set). Wiley-VCH, 2003.

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43

H, Persing David, ed. PCR protocols for emerging infectious diseases: A supplement to Diagnostic Molecular Microbiology : principles and applications. Washington, D.C: ASM Press, 1996.

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44

Pcr Protocols for Emerging Infectious Diseases A Supplement to Diagnostic Molecular Microbiology: Principles and Applications. ASM Press, 1996.

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45

Saghir, Akhtar, ed. Delivery strategies for antisense oligonucleotide therapeutics. Boca Raton: CRC Press, 1995.

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46

(Editor), John N. Abelson, Melvin I. Simon (Editor), and John J. Langone (Editor), eds. Molecular Design and Modeling: Concepts and Applications, Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs, Volume 203: Volume ... and Modelling Part B (Methods in Enzymology). Academic Press, 1991.

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47

Wójcik-Gładysz, Anna. Ghrelin – hormone with many faces. Central regulation and therapy. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_awg_2020.

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Discovered in 1999, ghrelin, is one of the peptides co-creating the hypothalamicgastrointestinal axis, otherwise known as the brain-gut axis. Ghrelin participates in many physiological processes and spectrum of its activity is still being discovered. This 28 amino acid peptide ‒ a product of the ghrl gene, was found in all vertebrates and is synthesized and secreted mainly from enteroendocrine X/A cells located in the gastric mucosa of the stomach. Expression of the ghrelin receptor has been found in many nuclei of the hypothalamus involved in appetite regulation. Therefore it’s presumed that ghrelin is one of the crucial hormones deciphering the energy status required for the maintenance of organism homeostasis. Ghrelin acts as a signal of starvation or energy insufficiency and its level in plasma is reduced after the meal. Neuropeptide Y (NPY) and agouti-related peptide (AgRP; NPY/AgRP) neurons located in the arcuate nucleus (ARC) area are the main target of ghrelin in the hypothalamus. This subpopulation of neurons is indispensable for inducing orexigenic action of ghrelin. Moreover ghrelin acting as a neurohormone, mainly in the hypothalamus area, plays an important role in the regulation of growth and reproduction processes. Indeed, ghrelin action on reproductive processes has been observed in the systemic effects exerted at both hypothalamus-pituitary and gonadal levels. Similarly the GH-releasing ghrelin action was observed both on the hypothalamus level and directly on the somatotrophic cells in the pituitary and this dose-related GH releasing activity was found in in vitro as well as in in vivo experiments. In recent years, numerous studies revealed that ghrelin potentially takes part in the treatment of diseases associated with serious disturbances in the organism energy balance and/or functioning of the gastrointestinal tract. It was underlined that ghrelin may be a hormone with a broad spectrum of therapeutic effect on obesity and anorexia nervosa, as well as may also have protective effect on neurodegenerative diseases, inflammatory disorders or functional changes in the body caused by cancers. In overall, ghrelin treatment has been tested in over 100 preclinical studies with healthy volunteers as well as patients with various types of cancer, eating disorders such as anorexia nervosa and bulimia nervosa. It was observed that ghrelin has an excellent clinical safety profile and emerging side effects occurred only in 3–10% of patients and did not constitute a sufficient premise to discontinue the therapy. In general, it can be concluded that ghrelin may be sufficiently used as a prescription drug.
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48

Henri, Grosjean, ed. Fine-tuning of RNA functions by modification and editing. Berlin: Springer, 2005.

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49

(Editor), T. Kumazawa, L. Kruger (Editor), and K. Mizumura (Editor), eds. The Polymodal Receptor - A Gateway to Pathological Pain (Progress in Brain Research). Elsevier Science, 1996.

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50

Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Amsterdam: Elsevier, 1996.

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