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Relevant bibliographies by topics / Nucleocapsid Proteins/chemistry/*genetics

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Academic literature on the topic 'Nucleocapsid Proteins/chemistry/*genetics'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Nucleocapsid Proteins/chemistry/*genetics"

1

Szunerits, Sabine, Hiba Saada, Quentin Pagneux, and Rabah Boukherroub. "Plasmonic Approaches for the Detection of SARS-CoV-2 Viral Particles." Biosensors 12, no. 7 (2022): 548. http://dx.doi.org/10.3390/bios12070548.

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The ongoing highly contagious Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underlines the fundamental position of diagnostic testing in outbreak control by allowing a distinction of the infected from the non-infected people. Diagnosis of COVID-19 remains largely based on reverse transcription PCR (RT-PCR), identifying the genetic material of the virus. Molecular testing approaches have been largely proposed in addition to infectivity testing of patients via sensing the presence of viral particles of SARS-CoV-2 specific st

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Tao, Y., K. Tang, M. Shi, et al. "Genomic characterization of seven distinct bat coronaviruses in Kenya." Virus Res 167, no. 1 (2012): 67–73. https://doi.org/10.5281/zenodo.13504043.

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(Uploaded by Plazi for the Bat Literature Project) To better understand the genetic diversity and genomic features of 41 coronaviruses (CoVs) identified from Kenya bats in 2006, seven CoVs as representatives of seven different phylogenetic groups identified from partial polymerase gene sequences, were subjected to extensive genomic sequencing. As a result, 15-16kb nucleotide sequences encoding complete RNA dependent RNA polymerase, spike, envelope, membrane, and nucleocapsid proteins plus other open reading frames (ORFs) were generated. Sequences analysis confirmed that the CoVs from Kenya bat

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Tao, Y., K. Tang, M. Shi, et al. "Genomic characterization of seven distinct bat coronaviruses in Kenya." Virus Res 167, no. 1 (2012): 67–73. https://doi.org/10.5281/zenodo.13504043.

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(Uploaded by Plazi for the Bat Literature Project) To better understand the genetic diversity and genomic features of 41 coronaviruses (CoVs) identified from Kenya bats in 2006, seven CoVs as representatives of seven different phylogenetic groups identified from partial polymerase gene sequences, were subjected to extensive genomic sequencing. As a result, 15-16kb nucleotide sequences encoding complete RNA dependent RNA polymerase, spike, envelope, membrane, and nucleocapsid proteins plus other open reading frames (ORFs) were generated. Sequences analysis confirmed that the CoVs from Kenya bat

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Tao, Y., K. Tang, M. Shi, et al. "Genomic characterization of seven distinct bat coronaviruses in Kenya." Virus Res 167, no. 1 (2012): 67–73. https://doi.org/10.5281/zenodo.13504043.

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(Uploaded by Plazi for the Bat Literature Project) To better understand the genetic diversity and genomic features of 41 coronaviruses (CoVs) identified from Kenya bats in 2006, seven CoVs as representatives of seven different phylogenetic groups identified from partial polymerase gene sequences, were subjected to extensive genomic sequencing. As a result, 15-16kb nucleotide sequences encoding complete RNA dependent RNA polymerase, spike, envelope, membrane, and nucleocapsid proteins plus other open reading frames (ORFs) were generated. Sequences analysis confirmed that the CoVs from Kenya bat

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Tao, Y., K. Tang, M. Shi, et al. "Genomic characterization of seven distinct bat coronaviruses in Kenya." Virus Res 167, no. 1 (2012): 67–73. https://doi.org/10.5281/zenodo.13504043.

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(Uploaded by Plazi for the Bat Literature Project) To better understand the genetic diversity and genomic features of 41 coronaviruses (CoVs) identified from Kenya bats in 2006, seven CoVs as representatives of seven different phylogenetic groups identified from partial polymerase gene sequences, were subjected to extensive genomic sequencing. As a result, 15-16kb nucleotide sequences encoding complete RNA dependent RNA polymerase, spike, envelope, membrane, and nucleocapsid proteins plus other open reading frames (ORFs) were generated. Sequences analysis confirmed that the CoVs from Kenya bat

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Forcelloni, Sergio, Anna Benedetti, Maddalena Dilucca, and Andrea Giansanti. "Identification of Conserved Epitopes in SARS-CoV-2 Spike and Nucleocapsid Protein." Current Genomics 22, no. 7 (2021): 541–49. http://dx.doi.org/10.2174/1389202923666211216162605.

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that first occurred in Wuhan in December 2019. The spike glycoproteins and nucleocapsid proteins are the most common targets for the development of vaccines and antiviral drugs. Objective: We herein analyze the rate of evolution along with the sequences of spike and nucleocapsid proteins in relation to the spatial locations of their epitopes, previously suggested to contribute to the immune response caused by SARS-CoV-2 infections. Methods: We compare homologous proteins of seven human coronaviruses: HCoV

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Patarca, Roberto, and William A. Haseltine. "Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2." International Journal of Molecular Sciences 25, no. 6 (2024): 3378. http://dx.doi.org/10.3390/ijms25063378.

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Viruses provide vital insights into gene expression control. Viral transactivators, with other viral and cellular proteins, regulate expression of self, other viruses, and host genes with profound effects on infected cells, underlying inflammation, control of immune responses, and pathogenesis. The multifunctional Tat proteins of lentiviruses (HIV-1, HIV-2, and SIV) transactivate gene expression by recruiting host proteins and binding to transacting responsive regions (TARs) in viral and host RNAs. SARS-CoV-2 nucleocapsid participates in early viral transcription, recruits similar cellular pro

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Kirchdoerfer, Robert N., Erica Ollmann Saphire, and Andrew B. Ward. "Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex." Acta Crystallographica Section F Structural Biology Communications 75, no. 5 (2019): 340–47. http://dx.doi.org/10.1107/s2053230x19004424.

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Ebola virus is an emerging virus that is capable of causing a deadly disease in humans. Replication, transcription and packaging of the viral genome are carried out by the viral nucleocapsid. The nucleocapsid is a complex of the viral nucleoprotein, RNA and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. The 3.1 Å resolution single-particle cryo-electron microscopy structure of the nucleoprotein–RNA helical filament presented here resembles previous structures determined at lower resolution, while p

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Pulkkinen, Lauri Ilmari Aurelius, Sarah Victoria Barrass, Marie Lindgren, et al. "Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein." PLOS Pathogens 19, no. 2 (2023): e1011125. http://dx.doi.org/10.1371/journal.ppat.1011125.

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Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the endoplasmic reticulum membrane and acquires the viral envelope and the associated proteins. The coordination of the nucleocapsid components to the sites of assembly and budding are poorly understood. Here, we investigate the interactions of the wild-type and truncated capsid proteins with membranes with biophysical methods and model membrane sys

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Nemeth-Pongracz, V., O. Barabas, M. Fuxreiter, et al. "Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins." Nucleic Acids Research 35, no. 2 (2006): 495–505. http://dx.doi.org/10.1093/nar/gkl1074.

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Dissertations / Theses on the topic "Nucleocapsid Proteins/chemistry/*genetics"

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Gelfand, Craig Alan. "Structural and functional studies of retroviral nucleocapsid proteins." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062090926.

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Zhang, Xinsheng. "Structural and functional interactions between measles virus nucleocapsid protein and cellular heat shock protein." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078417800.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 155 p.; also includes graphics (some col.) Includes bibliographical references (p. 147-155). Available online via OhioLINK's ETD Center

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Spell, Sarah. "The Study of Au(III) Compounds and their Interaction with Zinc Finger Proteins." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/634.

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Gold compounds have been used in medicine dating back as early as 2500 BC. Over the years gold(I) and gold(III) compounds have been used and designed to target rheumatoid arthritis, cancer, and viral diseases. New drug targets have been found for gold compounds that give insight into their mechanisms of action. Here we focus on the synthesis of Au(III) compounds designed to selectively target zinc finger (ZF) proteins. ZF proteins exhibit a variety of functions, including transcription, DNA repair, and apoptosis. Displacement of the central zinc ion, along with mutation of coordinated amino ac

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Yadav, Avinash. "Comprehensive proteogenomics identification and validation of cancer associated proteoforms in MCF7 cells." Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85821.

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Proteomics investigations rely on reference proteomes for the identification of proteins. These reference proteomes reflect the proteins that can be produced by an ideal organism, and so explicitly exclude protein isoforms that may be produced as a result of genetic mutation. In order to identify non-reference, or non-canonical, proteoforms the results of genomics analyses must be incorporated into the protein identification workflow. I developed such a proteogenomics workflow for the comprehensive identification and validation of non-canonical proteins. This development was performed using MC

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Wilman, Henry R. "Computational studies of protein helix kinks." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:21225f0e-efed-49c6-af27-5d3fe78fa731.

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Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another. Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error in the kink angle. Second the B statistic, a statistically robust method for identifying kinks. Third, Alpha Helic

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Fu, Josephine K. Y. "Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39bc18bb-16cb-4549-94cd-5f872daafe7e.

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In addition to a central circadian clock in the suprachiasmatic nucleus (SCN), zebrafish (Danio rerio) have local clock systems in their peripheral tissues. These peripheral tissues express a complement of clock genes that can be synchronized with the 24 h light/dark cycle and thus may be entrained by light. To date, teleost multiple tissue (tmt) opsin identified from Fugu rubripes and Danio rerio is the only opsin that has been proposed as a candidate to mediate this cellular photoentrainment (Moutsaki et al., 2003). Here we report the discovery of a multigene family of tmt opsins found not o

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Ramraj, Varun. "Exploiting whole-PDB analysis in novel bioinformatics applications." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6c59c813-2a4c-440c-940b-d334c02dd075.

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The Protein Data Bank (PDB) is the definitive electronic repository for experimentally-derived protein structures, composed mainly of those determined by X-ray crystallography. Approximately 200 new structures are added weekly to the PDB, and at the time of writing, it contains approximately 97,000 structures. This represents an expanding wealth of high-quality information but there seem to be few bioinformatics tools that consider and analyse these data as an ensemble. This thesis explores the development of three efficient, fast algorithms and software implementations to study protein struct

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Jain, Jayati. "Engineering antibodies to study and improve immunomagnetic isolation of tumour cells." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:81355801-b331-4705-bfef-204a29ee0347.

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Cell separation based on antibody-targeted magnetic beads has been widely used in a number of applications in immunology, microbiology, oncology and more recently, in the isolation of circulating tumour cells (CTCs) in cancer patients. Although other cell separation techniques such as size based cell filtration and Fluorescence Activated Cell Sorting have also been in popular use, immunomagnetic cell isolation possesses the advantages of high throughput, good specificity and reduced cell stress. However, certain fundamental features of the cell-bead interface are still unknown. In this study,

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Wu, Dong. "Design, synthesis, and assembly of genetically engineered proteins: Simple routes to biocatalytic surfaces." 1997. https://scholarworks.umass.edu/dissertations/AAI9809413.

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Hybrid artificial proteins, in which artificial repetitive polypeptides are fused with natural proteins or subunits, are proposed as a new approach to combining materials properties with the biological functions of natural proteins. As a model system, we have produced hybrid artificial proteins as "sticky enzymes" where the artificial domain serves to bind to surfaces while the natural domain performs catalytic activities. The artificial domains are repetitive polypeptides designed to provide multiple acidic functional groups and/or adopt regular secondary structures. A family of artificial pr

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"RNA determinants of specificity of two phylogenetically related single-stranded DNA-binding proteins." Tulane University, 1997.

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The work described in this dissertation provides insights into the role of the RNA pseudoknot structure in determining specificity of translational regulation by RNA-binding proteins. We have addressed the issue of specificity through a phylogenetic approach using two distantly related phages, T4 and RB69 We have cloned gene 32, the structural gene for Ssb protein of phage RB69 and shown both in vivo and in vitro that this protein controls its own biosynthesis at the translational level. The T4 and RB69 Ssb homologues exhibited differential complementing activities in vivo, and preference for

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Books on the topic "Nucleocapsid Proteins/chemistry/*genetics"

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Tom, Moss, and Leblanc Benoît, eds. DNA-protein interactions: Principles and protocols. 3rd ed. Humana Press, 2009.

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R, Pennington S., and Dunn M. J, eds. Proteomics: From protein sequence to function. BIOS, 2001.

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Spangler, Brenda D. Methods in molecular biology and protein chemistry: Cloning and characterization of an enterotoxin subunit. Wiley, 2002.

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Chen, Guodong. Characterization of Protein Therapeutics using Mass Spectrometry. Springer US, 2013.

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1958-, Brown Susan C., and Lucy Jack A. 1929-, eds. Dystrophin: Gene, protein, and cell biology. Cambridge University Press, 1997.

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Milan, Potmesil, and Kohn Kurt W, eds. DNA topoisomerases in cancer. Oxford University Press, 1991.

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1949-, Müller S. C., ed. Synthetic peptides as antigens. Elsevier, 1999.

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Whitford, David. Proteins. Wiley & Sons, Incorporated, John, 2005.

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Seitz, Harald. Analytics of Protein-DNA Interactions. Springer, 2010.

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Seitz, Harald. Analytics of Protein-DNA Interactions. Springer London, Limited, 2006.

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Book chapters on the topic "Nucleocapsid Proteins/chemistry/*genetics"

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Vilotte, J. L., E. Chanat, F. Le Provost, C. B. A. Whitelaw, A. Kolb, and D. B. Shennan. "Genetics and Biosynthesis of Milk Proteins." In Advanced Dairy Chemistry. Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-4714-6_14.

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Shewry, Peter R., Nigel G. Halford, and Arthur S. Tatham. "The High Molecular Weight Subunits Of Wheat, Barley And Rye: Genetics, Molecular Biology, Chemistry And Role In Wheat Gluten Structure And Functionality." In Oxford Surveys of Plant Molecular and Cell Biology. Oxford University PressOxford, 1990. http://dx.doi.org/10.1093/oso/9780198577355.003.0006.

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Abstract Although almost unheard of only a decade ago, the High Molecular Weight subunits of wheat glutenin have since become the most intens¬ ively studied group of wheat proteins. This is in spite of the fact that they account for only about 5% of the total proteins of the mature grain. This sudden interest resulted from the demonstration by Payne and coworkers at the Plant Breeding Institute (Cambridge, UK) that allelic variation in the polypeptide composition of the HMW subunits was closely correlated with the breadmaking quality of European cultivars of wheat, and of the progeny of crosse

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Kay, Lily E. "From Flies to Molecules: Physiological Genetics During the Morgan Era." In The Molecular Vision of Life. Oxford University PressNew York, NY, 1992. http://dx.doi.org/10.1093/oso/9780195058123.003.0006.

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Abstract Jack Schultz’s work constituted probably the earliest linkages between genetics, physiology, and the physicochemical studies of proteins and nucleic acids. When Schultz announced his interest in the biochemistry and physiology of heredity during the late 1920s, his ideas floated in the margins of American genetics. “Doing genetics” meant primarily Mendelian analyses. “I am very sorry to have given you the impression that I have lost my interest in genetics,” Schultz had to defend his position to T. H. Morgan in 1929 to salvage his research plans at Caltech. “This is far from the case.

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Mayer, Michael, Samuel Terrettaz, Laurent Giovangrandi, Thierry Stora, and Horst Vogel. "Functional analysis of ion channels: Planar patch clamp and impedance spectroscopy of tethered lipid membranes." In Biosensors. Oxford University PressOxford, 2004. http://dx.doi.org/10.1093/oso/9780199638468.003.0008.

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Abstract Ion channels play essential roles in cellular processes such as maintenance of the membrane potential, signal transduction, and osmoregulation and are therefore directly or indirectly targeted by many clinically used drugs (1). Despite the importance of ion channels, the molecular mechanisms of their function are largely unresolved. A nearly unlimited number of mutant proteins provided by combinatorial genetics (2, 3) and huge libraries of potentially active compounds produced by combinatorial chemistry (4) offer enormous possibilities for unraveling molecular details of channel funct

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Wilkins, Maurice. "Crystal Ganes." In The Third Man of the Double Helix. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780198606659.003.0005.

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Abstract Then came the very big news that DNA was the gene material. For about two years our lab had a special advantage in knowing this; the scientific community as a whole was still living in the belief that DNA was little more than an accessory to the proteins that were the basic element of genes. DNA had seemed much too simple to be gene material. We obtained this very important understanding of DNA because our lab had research students who were not weighed down by the authority of older scientists (Honor Fell, though an authority, did not throw her weight about). The crucial person was re

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Aebersold, Ruedi, Scott D. Patterson, and Daniel Hess. "Strategies for the Isolation of Peptides from Low-Abundance Proteins for Internal Sequence Analysis33Work was supported in part by the Genetics Network of Centres of Excellence (Canada) and by the Biomedical Research Centre. R.A. was the recipient of an MRC of Canada Scholarship. D.H. was the recipient of a fellowship from the Swiss National Science FoundationAbbreviations: BNPS-skatole: 2-(2’-nitrophenylsulfenyl)-3-methyl-3’-bromoindolenine; BSA: bovine serum albumin; CAPS: 3-[cyclohexylamino]-1-propanesulfonic acid; CD: Cationic Durapore; CNBr: cyanogen bromide; GuHCl: Guanidine hydrochloride; IPG-IEF: immobilized pH gradient isoelectric focusing; NC: nitrocellulose; PVDF: polyvinylidene fluoride; PVP: polyvinylpyrrolidone; RP-HPLC: reverse phase-high performance liquid chromatography; SDS-PAGE: sodium dodecyl sulfate polsyacrylamide gel electrophoresis; 2DE: two-dimensional gel electrophoresis; TFA: trifluoroacetic acid." In Techniques in Protein Chemistry III. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-12-058756-8.50015-8.

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