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Relevant bibliographies by topics / Nucleophilic substitution reaction mechanisms

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Academic literature on the topic 'Nucleophilic substitution reaction mechanisms'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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Journal articles on the topic "Nucleophilic substitution reaction mechanisms"

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Zhang, Xin, Jingyun Ren, Siu Min Tan, Davin Tan, Richmond Lee, and Choon-Hong Tan. "An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction." Science 363, no. 6425 (2019): 400–404. http://dx.doi.org/10.1126/science.aau7797.

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Bimolecular nucleophilic substitution (SN2) plays a central role in organic chemistry. In the conventionally accepted mechanism, the nucleophile displaces a carbon-bound leaving group X, often a halogen, by attacking the carbon face opposite the C–X bond. A less common variant, the halogenophilic SN2X reaction, involves initial nucleophilic attack of the X group from the front and as such is less sensitive to backside steric hindrance. Herein, we report an enantioconvergent substitution reaction of activated tertiary bromides by thiocarboxylates or azides that, on the basis of experimental and

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SHORTER, J. "ChemInform Abstract: Nucleophilic Aliphatic Substitution (Organic Reaction Mechanisms)." ChemInform 22, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199145328.

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SHORTER, J. "ChemInform Abstract: Nucleophilic Aliphatic Substitution (Organic Reaction Mechanisms)." ChemInform 25, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199418286.

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CRAMPTON, M. R. "ChemInform Abstract: Nucleophilic Aromatic Substitution (Organic Reaction Mechanisms)." ChemInform 25, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199413288.

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CRAMPTON, M. R. "ChemInform Abstract: Nucleophilic Aromatic Substitution (Organic Reaction Mechanisms)." ChemInform 22, no. 45 (2010): no. http://dx.doi.org/10.1002/chin.199145325.

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Mąkosza, Mieczysław. "How Does Nucleophilic Aromatic Substitution in Nitroarenes Really Proceed: General Mechanism." Synthesis 49, no. 15 (2017): 3247–54. http://dx.doi.org/10.1055/s-0036-1588444.

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On the basis of previously published experimental studies and ab initio calculations, a general corrected mechanism of nucleophilic aromatic substitution was formulated. It was shown that conventional nucleophilic substitution of halogens is a slow secondary reaction whereas nucleophilic substitution of hydrogen is the fast primary process. The general mechanism embraces both of these alternative and complementary reactions.

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Nudelman, Norma Sbarbati, Cecilia E. Silvana Alvaro, Monica Savini, Viviana Nicotra, and Jeannette Yankelevich. "Effects of the Nucleophile Structure on the Mechanisms of Reaction of 1-Chloro-2,4-dinitrobenzene with Aromatic Amines in Aprotic Solvents." Collection of Czechoslovak Chemical Communications 64, no. 10 (1999): 1583–93. http://dx.doi.org/10.1135/cccc19991583.

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The kinetics of reactions of 1-chloro-2,4-dinitrobenzene with aniline and several substituted aromatic amines, B, in toluene shows a quadratic dependence of the second-order rate constant, kA, on [B], which is preserved even in the presence of increasing amounts of dimethylaniline, while the reaction with N-methylaniline shows a linear dependence of kA vs [B]. All these results are interpreted by the "dimer nucleophile" mechanism, and confirmed by the effects of a non-nucleophilic hydrogen bond acceptor tertiary amine which show the relevance of the structure of the nucleophile and the role of

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Ding, Yan. "A Brief Discussion on Nucleophilic Substitution Reaction on Saturated Carbon Atom." Applied Mechanics and Materials 312 (February 2013): 433–37. http://dx.doi.org/10.4028/www.scientific.net/amm.312.433.

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Nucleophilic substitution reaction is an important reaction of haloalkane. By such a reaction, halogen functional group can turn into various other functional groups. Therefore, it is widely used in organic synthesis and there are many researches on its reaction mechanism. Hydrolysis reaction of bromoalkane is especially a nucleophilic substitution reaction that is studied quite fully. This paper mainly discusses the nucleophilic substitution reaction on saturated carbon atom.

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Ardèvol, Albert, Javier Iglesias-Fernández, Víctor Rojas-Cervellera, and Carme Rovira. "The reaction mechanism of retaining glycosyltransferases." Biochemical Society Transactions 44, no. 1 (2016): 51–60. http://dx.doi.org/10.1042/bst20150177.

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The catalytic mechanism of retaining glycosyltransferases (ret-GTs) remains a controversial issue in glycobiology. By analogy to the well-established mechanism of retaining glycosidases, it was first suggested that ret-GTs follow a double-displacement mechanism. However, only family 6 GTs exhibit a putative nucleophile protein residue properly located in the active site to participate in catalysis, prompting some authors to suggest an unusual single-displacement mechanism [named as front-face or SNi (substitution nucleophilic internal)-like]. This mechanism has now received strong support, fro

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Lu, Xiaosong, and John Warkentin. "Mechanism of ipso aromatic substitution by reaction of aryloxy(methoxy)carbenes and diaryloxycarbenes with DMAD." Canadian Journal of Chemistry 79, no. 4 (2001): 364–69. http://dx.doi.org/10.1139/v01-029.

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Some aryloxy(methoxy)carbenes and diaryloxycarbenes attack dimethyl acetylenedicarboxylate (DMAD) with aryl group transfer to an alkyne carbon of DMAD. In this study diaryloxycarbenes with different aryl groups that could be transferred competitively, were generated in the presence of DMAD to probe for the mechanism of that ipso aromatic substitution. It was found that a para electron-withdrawing substituent, relative to an electron-donating substituent, facilitated migration of an aryl group. Mechanisms in accord with these findings involve initial nucleophilic attack by the carbene at an alk

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Dissertations / Theses on the topic "Nucleophilic substitution reaction mechanisms"

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Parker, David J. "Modelling nucleophilic substitution at main group elements by NMR spectroscopy and X-ray crystallography." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363493.

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Dolliver, Debra D. "Mechanisms of Methoxide Ion Substitution and Acid- Catalyzed Z/E Isomerization of N-Methoxyimines." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc3017/.

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The second order rate constants for nucleophilic substitution by methoxide of (Z)- and (E)-O-methylbenzohydroximoyl fluorides [C6H4C(F)=NOCH3] with various substituents on the phenyl ring [p-OCH3 (1h, 2h), p-CH3 (1g, 2g), p-Cl (1f, 2f), p-H (1e, 2e), (3,5)-bis-CF3 (1i, 2i)] in 90:10 DMSO:MeOH have been measured. A Hammett plot of these rate constants vs σ values gave positive ρ values of 2.95 (Z isomer) and 3.29 (E isomer). Comparison of these rates with methoxide substitution rates for Omethylbenzohydroximoyl bromide [C6H4C(Br)=NOCH3] and Omethylbenzohydroximoyl chloride [C6H4C(Cl)=NOCH3] r

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Moagi, Kgotso Herbet. "Reaction Mechanism of 2-monosubstituted Quinoxalines with Organolithium Compounds : a Theoretical Study." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75182.

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This dissertation describes the density functional theory (DFT) computational modelling of reactions between organolithium nucleophiles and various substituted quinoxalines. These reactions result in the functionalisation of the C (sp2)–H bond, thus substituting the sigma-hydrogen. The reactions are known as nucleophilic substitution of hydrogen (SNH) and are used by experimental chemists to form new C–C bonds. The SNH reactions are very important in various industries, e.g. in designing and manufacturing of pharmaceuticals. Quinoxaline is widely used in medicinal chemistry due to its various

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Brammer, Larry E. "The elucidation of single electron transfer (SET) mechanisms in the reactions of nucleophiles with carbonyl compounds." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-06062008-151247/.

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MacMillar, Susanna. "Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis (AUU), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7441.

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Chamseddine, Yssam. "Sondes mecanistiques chirales et/ou regioselectivement deuteriees : application a l'etude de quelques processus de substitution nucleophile." Paris 6, 1988. http://www.theses.fr/1988PA066133.

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Belknap, Ethan M. "Computational Model of the Nucleophilic Acyl Substitution Pathway." Wittenberg University Honors Theses / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wuhonors1623251026132848.

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Curry, Omadee S. "Reaction of o-Nitrobenzenesulfonyl Azide/n-Butyl Lithium with Hindered Alcohols." Youngstown State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1379945812.

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Buquoi, John Quentin III. "Exploration Using Reaction Temperature to Tailor the Degree of Order in Micro-Block Copolymer Proton Exchange Membranes." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1274493418.

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Kahef, Lana el. "Oxydation des mesotetraphenyl porphyrines : beta-substitution par voie electrochimique directe." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13221.

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Book chapters on the topic "Nucleophilic substitution reaction mechanisms"

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Knipe, A. C. "Nucleophilic Aliphatic Substitution." In Organic Reaction Mechanisms · 2014. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781118941829.ch7.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2006. John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470669587.ch5.

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Westaway, K. C. "Nucleophilic Aliphatic Substitution." In Organic Reaction Mechanisms · 2006. John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470669587.ch8.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2008. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch5.

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Knipe, A. C. "Nucleophilic Aliphatic Substitution." In Organic Reaction Mechanisms · 2008. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch8.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch5.

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Westaway, K. C. "Nucleophilic Aliphatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch8.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch5.

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Westaway, K. C. "Nucleophilic Aliphatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch8.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470022051.ch5.

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Conference papers on the topic "Nucleophilic substitution reaction mechanisms"

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Peixoto, Bárbara Pereira, José Walkimar de M. Carneiro, and Rodolfo Goetze Fiorot. "Substituição nucleofílica alifática: qual o mecanismo preferencial? Estudo computacional dos efeitos da estrutura do substrato e solvente." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020122.

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Nucleophilic aliphatic substitution reactions constitute important steps in the synthesis of substances with biological activity and industrial appeal, beyond to participating in steps in biosynthetic routes of natural products. Unimolecular (SN1) and bimolecular (SN2) pathways can be understood as limiting cases of a mechanistic continuum. In between them, borderline mechanisms are proposed. The preference for one path over another depends on several factors, such as the structure of the substrate, the nucleophile and the solvent used. This plurality is still a topic of discussion and needs f

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Tang, Y. C. Alicia, S. M. Zain, and N. Abdul Rahman. "Knowledge Representation and Simulation of Nucleophilic Substitution Reaction using Qualitative Reasoning Approach." In TENCON 2006 - 2006 IEEE Region 10 Conference. IEEE, 2006. http://dx.doi.org/10.1109/tencon.2006.343880.

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Budruev, Andrei, and Evgenja Schelokova. "Nucleophilic Substitution Reaction of the Acyl Azides with Secondary Amines Mediated by Copper(II) Salt." In The 16th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2012. http://dx.doi.org/10.3390/ecsoc-16-01047.

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Shutalev, Anatoly, Ludmila Trafimova, and Anastasia Fesenko. "Two Pathways for the Reaction of Ethyl 4-Chloromethyl-6-methyl- 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate with Thiophenolates: Ring Expansion versus Nucleophilic Substitution." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00456.

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Homem-de-Mello, P., E. A. Takeuchi, E. M. C. de Lima, et al. "Evaluation of computational approaches to design new photosensitizers." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020-29.

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From dye-sensitized solar cells to photodynamic therapy, the design of new photosensitizers involves different computational strategies. In this work, we present selected examples aiming at illustrating the limitations and advantages of each selected strategy, as well as listing useful descriptors. Hybrid functionals are reasonable approaches to determine properties related to the electronic absorption spectrum; however, for metallic complexes such as metalloporphyrins, one may be careful in selecting the DFT approach. Self-aggregation of dyes is a phenomenon the experimentalists try to avoid,

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Lee, Won Geun, and David Montgomery. "Numerical Investigation of the Performance of a High Pressure Direct Injection (HPDI) Natural Gas Engine." In ASME 2014 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icef2014-5681.

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High Pressure Direct-Injection (HPDI) is a technology option for engines used in mobile equipment applications where use of LNG as a fuel is desired. Using the combination of a diesel pilot injection and direct gas injection, HPDI has the potential to deliver low emissions, excellent transient performance, high efficiency, and high gas substitution. When the HPDI program was initially undertaken, in order to aid in initial hardware design, 3-dimensional computational fluid dynamic modeling was conducted to understand the mixing and reaction processes in the combustion chamber of an HPDI engine

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