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Dissertations / Theses on the topic 'Nucleosideos - Metabolismo'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Saraiva, Antonio Marcos. "Caracterização funcional e estrutural da nucleotidase SurE de Xyllela fastidiosa." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316474.

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Orientador: Anete Pereira de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-14T21:21:36Z (GMT). No. of bitstreams: 1 Saraiva_AntonioMarcos_D.pdf: 12032714 bytes, checksum: 1262a05ca10735e855fa138a2093d04b (MD5) Previous issue date: 2009<br>Resumo: A linhagem 9a5c da bactéria Xylella fastidiosa foi o primeiro fitopatógeno a ter seu genoma completamente sequenciado, o qual gerdu diversas informações sobre seu metabolismo e patogenicidade. Das orfs codificadas por esta bactéria, destaca-se; no presente trabalho, a XF07

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2

Andrade, Claudia Marlise Balbinotti. "Estudo das ectonucleotidases em células estreladas hepáticas : relação entre a expressão, atividade e significado fisiológico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/15499.

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As células estreladas hepáticas (HSCs) são a principal fonte de componentes de matriz extracelular em doenças crônicas do fígado e, por esta razão, exercem um papel fundamental no desenvolvimento e na manutenção da fibrose hepática. Os nucleotídeos e nucleosídeos são moléculas sinalizadoras que regulam diversos processos no fígado e têm um importante papel na patogênese da fibrose hepática. As ecto-nucleosídeo trifosfato difosfoidrolases (E-NTPDases), ecto-nucleotídeo pirofosfatase fosfodiesterases (E-NPPs), ecto-5’-nucleotidase (eNT/CD73) e a fosfatase alcalina tecido inespecífica (TNALP) são

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3

Cabrera, Pérez Raquel. "Terapia génica para el MNGIE: Estudio comparativo de diferentes vectores adeno-asociados en el modelo preclínico de la enfermedad." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458540.

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El MNGIE (encefalomiopatía neurogastrointestinal mitocondrial) es una enfermedad rara de herencia autosómica recesiva que provoca afectación de la función muscular, neuronal y gastrointestinal y cuya esperanza de vida se sitúa en torno a los 37 años. Está causada por mutaciones en el gen nuclear TYMP, que codifica la timidina fosforilasa (TP). La TP cataliza el primer paso del catabolismo de los nucleósidos timidina (dThd) y desoxiuridina (dUrd), por lo que disfunciones en esta enzima provocan la acumulación sistémica de estos nucleósidos. La sobrecarga de dThd y dUrd da lugar a un exceso de d

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4

Scott, Allelia Worrall. "Pyrimidine Nucleoside Metabolism in Pseudomonads and Enteric Bacteria." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc500941/.

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Metabolic differences in the strategies used for pyrimidine base and nucleoside salvage were studied in the pseudomonads and enteric bacteria. Fluoro--analogs were used to select mutant strains of E. coli, S. typhimurium, P. putida, and P. aeruginosa blocked in one or more of the uracil and uridine salvage enzymes. HPLC analysis of cell-free extracts from wild-type and mutant strains examined the effectiveness of the selections. Evidence was found for cytidine kinase in Pseudomonas and for an activity that converted uracil compounds to cytosine compounds. Using media supplemented with 150 μg o

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5

Cummins, Jane H. "Stereochemical studies in mechanistic enzymology using nucleoside phosphorothioates." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/34071.

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A simple method for the configurational analysis of the four major 2'-deoxynucleoside 5'-[160, 180] phosphorothioates, (1), and adenosine 5'-[160, 180] phosphorothioate, (1a), is described. The method involves permethylation of (1,1a) with diazomethane or dimethyl sulphate, to generate the corresponding S-methyl-O-methyl phosphorothioate, (2,2a), 8P(3:1 DMF:d4-MeOH) +30ppm. Having assigned the diastereoisomers of (2,2a) to their corresponding 31P.n.m.r. resonances, the 18O-isotope is located by examination of 31P(180) isotope shifts. A larger shift, (0.05ppm), is observed on the diastereoisome

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6

Borg, Natalia. "Distribution of antiviral nucleoside analogues to brain and skin /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3202-6/.

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7

Lee, Yick-Shun. "Pyrimidine Metabolism in Bacteria: Physiological Properties of Nucleoside Hydrolase and Uridine Kinase." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798309/.

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8

Stow, Ruth Anne. "Purine nucleoside transport and metabolism across the rat small intestine." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258382.

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9

Vodnala, Munender. "Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80904.

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Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs. T. brucei lacks de novo synthesis of purine nucleosides; hence it depends on the host to make its purine nucleotides. T. brucei has a high affinity adenosine kinase (TbAK), which phosphorylates adenosine, deoxyadenosine (dAdo), inosine and their analogs. RNAi experiments confirmed that TbAK is responsible for the salvage of dAdo and the toxicit

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10

Månsson, Emma. "Resistance mechanisms for nucleoside analogues - with focus on metabolism and apoptosis /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-330-9/.

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11

Kohyama, Naoki. "Synthesis of nucleoside derivatives directed toward clarification of glucose metabolism activation." Kyoto University, 2005. http://hdl.handle.net/2433/144981.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第11682号<br>人博第288号<br>新制||人||72(附属図書館)<br>16||179(吉田南総合図書館)<br>23325<br>UT51-2005-D431<br>京都大学大学院人間･環境学研究科文化･地域環境学専攻<br>(主査)教授山本行男, 教授山口良平, 教授田村類, 助教授林達也<br>学位規則第4条第1項該当

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12

Lundgren, Hans. "Formation of Thiolated Nucleosides in tRNA in Salmonella enterica serovar typhimurium." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-857.

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The presence and synthesis of transfer RNA (tRNA) is highly conserved in all organisms and a lot of genetic material is dedicated to its synthesis. tRNA contains a large number of modified nucleosides and several diverse functions have been found but much about their function is still unknown. By using a novel frameshifting system to select for tRNA modification mutants, new mutations were isolated and subsequently analyzed. This thesis examines the synthesis and function of a subset of tRNA modifications that have a sulfur (thio) -group as part of the modification. The isc operon encodes for

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13

Bierau, Jörgen. "The pivotal role of CTP synthetase in the metabolism of (deoxy)nucleosides in neuroblastoma." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/70985.

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14

Fyrberg, Anna. "Nucleoside analoge cytotoxicity-focus on enzyme regulation, metabolism, and mechanisms of resistance." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-63247.

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The aim of this thesis was to determine the role of nucleoside analog activating and deactivating enzymes in nucleoside analog metabolism and resistance development. Nucleoside analogs are anti-cancer drogs and are often used to treat different leukemias, attributably to presence of high levels of nucleoside analog activating enzymes in hematopoietic cells. More recently some of the newer analogs have been used successfully to treat solid tumors as well. We have used human leukemic cell lines, and isolated cells from patients with leukemia, to investigate the nucleoside analog activating enzy

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15

Wehelie, Rahma. "Mycoplasma pyrimidine deoxynucleotide biosynthesis : molecular characterization of a new family flavin-dependent thymidylate synthase /." Uppsala : Dept. of Molecular Biosciences, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200676.pdf.

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16

Johansson, Magnus. "Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2696-4.

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17

Kavianipour, Mohammad. "Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism." Doctoral thesis, Umeå University, Public Health and Clinical Medicine, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14.

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<p>Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). Today, much is known about the signalling pathways involved in IP; however, the details of the final steps leading to cardioprotection, remain elusive. Adenosine (a catabolite of ATP) plays a major role in the signalling pathways of IP. Following IP there is an unexplained discrepancy between an increased adenosine production (evidenced by increased 5’-nucleotidase activity) and the successive

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18

Fromentin, Emilie. "Quantitative metabolism of natural and antiviral nucleosides and nucleotides in human cells by LC-MS/MS." AgroParisTech, 2010. http://pastel.archives-ouvertes.fr/docs/00/60/59/11/PDF/These_Emilie_Fromentin.pdf.

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Notre laboratoire, Laboratory of Biochemical Pharmacology (LOBP), dirigé par Dr R. F. Schinazi, est spécialisé dans la recherche sur les nucléosides analogues et plus particulièrement les inhibiteurs de la transcriptase inverse. Au sein de ce laboratoire, l'équipe de pharmacologie a pour rôle d'étudier le métabolisme des molécules en développement ainsi que des molécules déjà commercialisées dans des cellules humaines en culture. Les résultats obtenus guident les chimistes vers une synthèse de composés plus actif et moins toxiques. Pour les molécules les plus avancées, comme l'amdoxovir TM , l

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19

Aono, Riku. "Studies on nucleotide and pentose metabolism in Archaea." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/200451.

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20

Zhu, Chaoyong. "Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4367-2/.

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21

Fields, Christopher J. "Comparative biochemistry and genetic analysis of nucleoside hydrolase in Escherichia coli, Pseudomonas aeruginosa, and Pseudomonas fluorescens." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3290/.

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The pyrimidine salvage enzyme, nucleoside hydrolase, is catalyzes the irreversible hydrolysis of nucleosides into the free nucleic acid base and D-ribose. Nucleoside hydrolases have varying degrees of specificity towards purine and pyrimidine nucleosides. In E. coli, three genes were found that encode homologues of several known nucleoside hydrolases in protozoa. All three genes (designated yaaF, yeiK, and ybeK) were amplified by PCR and cloned. Two of the gene products (yeiK and ybeK) encode pyrimidine-specific nucleoside hydrolases, while the third (yaaF) encodes a nonspecific nucleoside hy

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22

Hammargren, Jenni. "Novel functions of the mitochondrial nucleoside diphosphate kinase in plants /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200787.pdf.

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23

Frijus-Plessen, Nicole. "Untersuchungen zu Aufnahme, Metabolismus und Pharmakokinetik von modifizierten Nukleosiden als Therapeutika von HIV-Infektion und Tumorerkrankungen /." [S.l. : s.n.], 1992. http://www.gbv.de/dms/bs/toc/120789442.pdf.

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24

Sinclair, Christopher J. D. "Regulation of extracellular adenosine levels, role of nucleoside transporters, purine metabolism and the blood-brain-barrier." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ62667.pdf.

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25

Ntshongontshi, Nomaphelo. "Cytochrome P450-3A4/copper-poly(propylene imine)- polypyrrole star co-polymer Nanobiosensor system for delavirdine – a non-nucleoside reverse transcriptase inhibitor HIV drug." University of the Western Cape, 2014. http://hdl.handle.net/11394/4446.

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>Magister Scientiae - MSc<br>HIV and AIDS are among the world's pandemics that pose serious concern to almost every individual in the world. With the current level of availability of anti-retroviral (ARV) drugs and the ease of accessibility of treatment in many countries such as South Africa, the disease can be controlled by suppressing the viral load of an infected individual. These anti HIV drugs such as delavirdine are metabolised by enzymes which are found in the liver microsomes, particularly those of the cytochrome P450 family. Due to the fact that the metabolic rate of a patient determi

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26

SELLAM, OLIVIER. "La nucleoside diphosphate kinase des proprietes regulatrices pour une enzyme du metabolisme ? contribution a l'etude de la ndp kinase de dictyostelium discoideum." Paris 7, 1998. http://www.theses.fr/1998PA077149.

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La nucleoside diphosphate kinase (ndp kinase) est une enzyme du metabolisme qui catalyse la synthese des ribo- et desoxyribo-nucleosides triphosphates a partir de leurs precurseurs diphosphates selon un mecanisme de type ping-pong. C'est un hexamere de sous-unites identiques de 17 kda dont la structure tridimensionnelle est connue. L'implication de ndp kinases dans le developpement et la metastase a ete mise en evidence respectivement chez l'homme et la drosophile. Par ailleurs, il a ete recemment montre que la ndp kinase humaine est capable de se fixer sur le promoteur de l'oncogene c-myc et

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27

Narasimhan, Sri Devi. "Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/509.

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The lifespan of an organism is determined by a complex array of genetic, environmental and nutritional factors. Yet single gene manipulations have been shown to significantly extend lifespan in several model organisms. Of all the genes that have been studied thus far, components of the insulin/IGF-1 signaling (IIS) pathway have emerged as the most robust regulators of longevity. In addition, IIS also regulates development, energy metabolism and the response to stress in a conserved manner. In Caenorhabditis elegans, signaling through this pathway is initiated by activation of the insulin/IGF-1

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28

Neris, Débora Meira. "Efeito da imunização com enzimas recombinantes do metabolismo de nucleotídeos de Schistosoma mansoni sobre o desenvolvimento da esquistossomose mansônica experimental." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/7018.

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Made available in DSpace on 2016-08-17T18:39:46Z (GMT). No. of bitstreams: 1 5245.pdf: 1568165 bytes, checksum: 9fc25ff9dc83339e50628c08854efd2c (MD5) Previous issue date: 2012-08-29<br>Universidade Federal de Sao Carlos<br>Schistosimiasis mansoni is a neglected chronic parasitic disease that affects thousands of people worldwide, caused by the trematode Schistosoma mansoni. In the infected host the disease is characterized by the presence of granuloma, imunnopathological response of the cellular infiltration against egg antigens. Thus, the host-parasite relation favors hepatosplenomegaly, a

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29

Lin, Chien-Ling. "Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/583.

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Post-transcriptional regulation of gene expression sits at the core of proteomic complexity; trans-acting factors that regulate RNA localization and translation capacity are thus indispensible. In this thesis, I present studies of the cytoplasmic polyadenylation element binding protein (CPEB), a sequence specific RNA-binding protein important for cell cycle progression and neural synaptic plasticity. I focus on CPEB because the activity of RNA-binding proteins affects the destiny of their mRNA substrates. As presented in Chapter II, CPEB, though mostly cytoplasmic at steady state, shuttles bet

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30

Li, Zhonghan. "Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/607.

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Somatic cells could be reprogrammed into an ES-like state called induced pluripotent stem cells (iPSCs) by expression of four transcriptional factors: Oct4, Sox2, Klf4 and cMyc. iPSCs have full potentials to generate cells of all lineages and have become a valuable tool to understand human development and disease pathogenesis. However, reprogramming process suffers from extremely low efficiency and the molecular mechanism remains poorly understood. This dissertation is focused on studying the role of small non-coding RNAs (microRNAs) and kinases during the reprogramming process in order to und

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31

Beauvieux, Marie-Christine. "Etude par spectroscopie de résonance magnétique de la conservation du greffon épatique." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28265.

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32

Huber, Tyler D. "TOWARD AN ENZYME-COUPLED, BIOORTHOGONAL PLATFORM FOR METHYLTRANSFERASES: PROBING THE SPECIFICITY OF METHIONINE ADENOSYLTRANSFERASES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/106.

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Methyl group transfer from S-adenosyl-l-methionine (AdoMet) to various substrates including DNA, proteins, and natural products (NPs), is accomplished by methyltransferases (MTs). Analogs of AdoMet, bearing an alternative S-alkyl group can be exploited, in the context of an array of wild-type MT-catalyzed reactions, to differentially alkylate DNA, proteins, and NPs. This technology provides a means to elucidate MT targets by the MT-mediated installation of chemoselective handles from AdoMet analogs to biologically relevant molecules and affords researchers a fresh route to diversify NP scaffol

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33

Papinazath, Taniya. "The Effects of Purine Nucleoside Phosphorylase (PNP) Deficiency on Thymocyte Development." Thesis, 2010. http://hdl.handle.net/1807/24616.

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PNP is a crucial enzyme in purine metabolism, and its inherited defects result in severe T-lineage immune deficiency in humans. I hypothesized that PNP deficiency disrupts the development of late CD4-CD8- double negative (DN) thymocytes and induces mitochondrial-mediated apoptosis of CD4+CD8+ double positive (DP) thymocytes. By using PNP-deficient (PNP-/-) mice as well as an OP9-DL1 co-culture system simulating PNP-deficient conditions, I demonstrated that PNP deficiency interferes with the maturation of DN thymocytes at the transition from DN3 to DN4 stage. Although PNP deficiency does not

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34

Li, Ding-Jin, and 李定瑾. "The Role of Equilibrative Nucleoside Transporter 3 in T cell Development, Function and Metabolism." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/73577451198419543249.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>103<br>Immune system plays a crucial role in defending our body from the daily pathogen insults. To fight off pathogen invasion, immune cells especially T cells require versatile metabolic programs to match their functional needs. T cells go through drastic expansion, which is followed by contraction phase to regain homeostasis. This process requires exchanges of large amounts of energy and biomaterials. Although recently attention has been drawn to understanding the metabolic change in the immune response, it remains largely unknown how the availability of variou

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35

Gaur, Rahul. "Metabolism Of Queuosine, A Modified Nucleoside, In Escherichia Coli And Caenorhabditis Elegans And Dual Function Of Bovine Mitochondrial Initiation Factor 2 As Initiation Factors 1 And 2 In Escherichia Coli." Thesis, 2007. http://hdl.handle.net/2005/543.

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The studies reported in this thesis address firstly, the biology of a modified nucleoside, Queuosine (Q) and secondly, the properties of mitochondrial translation initiation factor 2. A summary of the relevant literature on both these topics is presented in Chapter 1. Section I of this ‘General Introduction’ summarizes the literature on biosynthesis and physiological importance of Queuosine. Section II is a brief review of the current understanding of translation initiation in Eubacteria. Information about the mitochondrial translation initiation apparatus also features as a subsection. The ne

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36

Santos, Inês Vasconcelos Miranda. "Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast a 13c based experimental-computational approach." Doctoral thesis, 2019. http://hdl.handle.net/10316/88784.

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Tese no âmbito do doutoramento em Biociências, área de Bioquímica e apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia.<br>Há cada vez mais evidências sobre alterações metabólicas significativas ao longo do ciclo de divisão celular (CDC) em células eucarióticas. No entanto, devido a limitações técnicas, não há informação quantitativa sobre a distribuição dos fluxos metabólicos (DFM) nas fases distintas do CDC. Nomeadamente, os métodos de sincronização do CDC perturbam o metabolismo sendo propensos a artefactos e os métodos de separação de células têm bai

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