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Relevant bibliographies by topics / Nucleosides Antiviral nucleosides

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Academic literature on the topic 'Nucleosides Antiviral nucleosides'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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Journal articles on the topic "Nucleosides Antiviral nucleosides"

1

Robins, Morris J., Danuta Madej, Fritz Hansske та ін. "Nucleic acid related compounds. 53. Synthesis and biological evaluation of 2′-deoxy-β-threo-pentofuranosyl nucleosides. "Reversion to starting alcohol" in Barton-type reductions of thionocarbonates". Canadian Journal of Chemistry 66, № 5 (1988): 1258–62. http://dx.doi.org/10.1139/v88-204.

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Treatment of selectively 3′,5′-protected β-D-xylofuranosyl nucleosides (4) with phenyl chlorothionocarbonate and DMAP followed by hydrogenolysis of the resulting (2′-O-phenoxythiocarbonyl) phenyl thionocarbonate esters (6) with tributylstannane/AIBN, and deprotection, gave 2′-deoxy-β-D-threo-pentofuranosyl nucleosides (7). Formation of a by-product bis(nucleosid-2′-yl)thionocarbonate dimer (8) was detected in the uracil nucleoside reaction sequence. Its subsequent reduction provides one explanation for "reversion to starting alcohol" in Barton-type deoxygenation reactions. Only the guanine 2′-

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2

Shi, Junxing, Judy S. Mathew, Phillip M. Tharnish, et al. "N4-Acyl-Modified D-2′,3′-Dideoxy-5-Fluorocytidine Nucleoside Analogues with Improved Antiviral Activity." Antiviral Chemistry and Chemotherapy 14, no. 2 (2003): 81–90. http://dx.doi.org/10.1177/095632020301400203.

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A series of 2,3-dideoxy (D2) and 2,3-didehydro-2,3-dideoxy (D4) 5-fluorocytosine nucleosides modified with substituted benzoyl, heteroaromatic carbonyl, cycloalkylcarbonyl and alkanoyl at the N4-position were synthesized and evaluated for anti-human immunodeficiency virus type 1 (HIV-1) and anti-hepatitis B virus (HBV) activity in vitro. For most D2-nucleosides, N4-substitutions improved the anti-HIV-1 activity markedly without increasing the cytotoxicity. In the D4-nucleosides series, some of the substituents at the N4-position enhanced the anti-HIV-1 activity with a modest increase in the cy

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3

Wiebe, Leonard, Edward Knaus, A. Majid Cheraghali, Rakesh Kumar, Kevin Morin, and L. Wang. "5-Halo-6-alkoxy-5,6-dihydro-pyrimidine Nucleosides: Antiviral Nucleosides or Nucleoside Prodrugs?" Nucleosides, Nucleotides and Nucleic Acids 14, no. 3 (1995): 501–5. http://dx.doi.org/10.1080/15257779508012413.

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4

Choo, Hyunah, James R. Beadle, Earl R. Kern, et al. "Antiviral Activities of Novel 5-Phosphono-Pent-2-en-1-yl Nucleosides and Their Alkoxyalkyl Phosphonoesters." Antimicrobial Agents and Chemotherapy 51, no. 2 (2006): 611–15. http://dx.doi.org/10.1128/aac.00444-06.

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ABSTRACT Three acyclic nucleoside phosphonates are currently approved for clinical use against infections caused by cytomegalovirus (Vistide), hepatitis B virus (Hepsera), and human immunodeficiency virus type 1 (Viread). This important antiviral class inhibits viral polymerases after cellular uptake and conversion to their diphosphates, bypassing the first phosphorylation, which is required for conventional nucleoside antivirals. Small chemical alterations in the acyclic side chain lead to marked differences in antiviral activity and the spectrum of activity of acyclic nucleoside phosphonates

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5

Young, James D. "The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey." Biochemical Society Transactions 44, no. 3 (2016): 869–76. http://dx.doi.org/10.1042/bst20160038.

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Specialized nucleoside transporter (NT) proteins are required for passage of nucleosides and hydrophilic nucleoside analogues across biological membranes. Physiologic nucleosides serve as central salvage metabolites in nucleotide biosynthesis, and nucleoside analogues are used as chemotherapeutic agents in the treatment of cancer and antiviral diseases. The nucleoside adenosine modulates numerous cellular events via purino-receptor cell signalling pathways. Human NTs are divided into two structurally unrelated protein families: the SLC28 concentrative nucleoside transporter (CNT) family and th

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6

Seley-Radtke, Katherine. "Flexibility—Not just for yoga anymore!" Antiviral Chemistry and Chemotherapy 26 (January 2018): 204020661875678. http://dx.doi.org/10.1177/2040206618756788.

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Over the past few years, nucleosides have maintained a prominent role as one of the cornerstones of antiviral and anticancer therapeutics, and many approaches to nucleoside drug design have been pursued. One such approach involves flexibility in the sugar moiety of nucleosides, for example, in the highly successful anti-HIV and HBV drug tenofovir. In contrast, introduction of flexibility to the nucleobase scaffold has only more recently gained significance with the invention of our fleximers. The history, development, and some biological relevance for this innovative class of nucleosides are d

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Cabrita, Miguel A., Stephen A. Baldwin, James D. Young, and Carol E. Cass. "Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes." Biochemistry and Cell Biology 80, no. 5 (2002): 623–38. http://dx.doi.org/10.1139/o02-153.

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The molecular cloning of cDNAs encoding nucleoside transporter proteins has greatly advanced understanding of how nucleoside permeants are translocated across cell membranes. The nucleoside transporter proteins identified thus far have been categorized into five distinct superfamilies. Two of these superfamilies, the equilibrative and concentrative nucleoside transporters, have human members and these will be examined in depth in this review. The human equilibrative nucleoside transporters translocate nucleosides and nucleobases bidirectionally down their concentration gradients and are import

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8

Erickson-Viitanen, Susan, Jing-Tao Wu, Guoen Shi, et al. "Cellular Pharmacology of D-d4FC, a Nucleoside Analogue Active against Drug-Resistant HIV." Antiviral Chemistry and Chemotherapy 14, no. 1 (2003): 39–47. http://dx.doi.org/10.1177/095632020301400104.

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The backbone of effective highly active antiretroviral therapy regimens for the treatment of HIV infections currently contains at least two nucleosides. Among the features that influence the potency of each component of a regimen and the overall efficacy of the combination are the cellular uptake and bioconversion of nucleoside analogues to their active triphosphate form, and the extent of possible interactions in these steps that might occur when more than one nucleoside is used in a regimen. D-d4FC (Reverset™), a new cytidine analogue with the ability to inhibit many nucleoside-resistant vir

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9

Komiotis, Dimitri, Stella Manta, Evangelia Tsoukala, and Niki Tzioumaki. "Antiviral Unsaturated Nucleosides." Anti-Infective Agents in Medicinal Chemistry 7, no. 4 (2008): 219–44. http://dx.doi.org/10.2174/187152108785908848.

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10

Lee, Kyeong, and Chung K. Chu. "Molecular Modeling Approach to Understanding the Mode of Action of l-Nucleosides as Antiviral Agents." Antimicrobial Agents and Chemotherapy 45, no. 1 (2001): 138–44. http://dx.doi.org/10.1128/aac.45.1.138-144.2001.

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ABSTRACT A series of unnatural l-nucleosides such as 3TC, FTC and l-FMAU have been found to be potent antiviral agents. The mode of action of l-nucleosides has been found to be similar to that of d-nucleosides as antiviral agents, despite their unnatural stereochemistry, that is, nucleotide formation by kinases followed by interaction with the reverse transcriptase (RT) of HIV or DNA polymerase. To date, the mode of action of nucleoside inhibitors at the molecular level with respect to the active conformations of the 5′-triphosphates as well as the interaction with the RT is not known. Recentl

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Dissertations / Theses on the topic "Nucleosides Antiviral nucleosides"

1

He, Mingzhu Schneller Stewart W. "Carbocyclic C-nucleosides derived from formycin." Auburn, Ala, 2008. http://hdl.handle.net/10415/1427.

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2

Popescu, Anne. "Racemic carbocyclic nucleosides and their anti-viral activity." Lund : Lund University Chemical Center, 1995. http://books.google.com/books?id=5vhqAAAAMAAJ.

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3

Shi, Houguang. "Synthesis and Antiviral Evaluation of Some 3'-Carboxymethyl-3'-deoxyadenosine Derivatives." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1940.pdf.

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4

Harrison, M. "Synthesis of acyclic c-nucleosides as potential antiviral agents." Thesis, Heriot-Watt University, 1988. http://hdl.handle.net/10399/1004.

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5

Bouali, Abderrahime. "#beta#-D-ketofuranosyl purine nucleosides as potential antiviral agents." Thesis, University of Lincoln, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359008.

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6

Boisvert, Suzanne 1955. "Preparation of novel heterocyclic-ring analogues of BIOLF-62 : application of 29SI NMR nucleosides and the investigation of 2,4-dinitrobenzenesulfenyl as a protecting group for ribonucleotide synthesis." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75365.

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In light of the remarkable antiviral activity of acyclic nucleoside analogues such as that of BIOLF-62 against the herpes viruses, a number of products in which heterocyclic bases were coupled to the active acyclic sugar moiety were prepared and submitted for biological testing.<br>Various dimethoxytritylated and t -butyldimethylsilylated derivatives of arabinoadenosine were prepared and fully characterised by $ sp1$H and $ sp{13}$C NMR spectroscopy. $ sp{29}$Si INEPT as well as $ sp{29}$Si-$ sp1{ rm H}$ correlated NMR were used to study various t -butyldimethylsilyl and triisopropylsilyl subs

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Angell, Annette. "The design, synthesis and evaluation of some novel antiviral nucleosides." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55384/.

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An investigation into the pH stability of the BCNAs was also carried out and the parent analogue bearing a pentyphenyl side chain was found to be stable at a range of pHs. Finally, with the X-ray crystal structure of VZV thymidine kinase published we began a preliminary investigation into the possible interaction the BCNAs with this enzyme using molecular modelling

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8

Clark, Sarah Alexandra. "The synthesis of 2-fluoromethyl nucleosides as potential antiviral agents." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492322.

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Nucleoside analogues are a vital class ofcompounds that are used in the treatment of AIDS and other viral infections. Research into the synthesis of2'-C-fluoromethyl cytosine is described. The key step in the synthesis involves the fluorination ofthe 2-Chydroxymethyl derivative of ribose with Deoxo-Fluoi'lY. The 2-C-hydroxymethyl compound is readily prepared from D-ribose on a multigram scale. Research was carried out into the synthesis of2', 3'-dideoi\.')'-2'-C-fluoromethyl-3'-Chydroxymethyl nucleosides using various different methodologies and a few different starting materials, including D-

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9

Thorpe, Andrew John. "Synthetic approaches to novel adenosine analogues and the synthesis of potential antiviral agents." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357951.

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Gould, Jayne H. M. "The synthesis of novel nucleosides and nucleotides as potential antiviral agents." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339518.

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Books on the topic "Nucleosides Antiviral nucleosides"

1

Chu, Chung K., and David C. Baker, eds. Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1.

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2

Dyson, Michael Richard. The synthesis of potential nucleoside phosphorylase-resistant antiviral agents. University of Birmingham, 1989.

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3

Shimizu, Shin-Ichiro. The synthesis of nucleoside and nucleotide analogues as potential antiviral agents. University of Birmingham, 1991.

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4

Antiviral Nucleosides. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-444-51319-9.x5000-3.

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5

Agrofoglio, L., and S. R. Challand. Carbocyclic, Acyclic and L-Nucleosides. Springer, 1998.

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6

Chu, C. K. Antiviral Nucleosides: Chiral Synthesis and Chemotherapy. Elsevier Science, 2003.

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7

K, Chu Chung, Baker David C. 1946-, and Symposium on Nucleosides as Antitumor and Antiviral Agents (1992 : San Francisco, Calif.), eds. Nucleosides and nucleotides as antitumor and antiviral agents. Plenum Press, 1993.

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8

Baker, D. C. Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer, 2012.

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9

Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley-VCH, 2008.

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10

Piet, Herdewijn, ed. Modified nucleosides: In biochemistry, biotechnology, and medicine. Wiley-VCH, 2008.

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Book chapters on the topic "Nucleosides Antiviral nucleosides"

1

Ray, Adrian S., and Michael J. M. Hitchcock. "Metabolism of Antiviral Nucleosides and Nucleotides." In Antiviral Research. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815493.ch17.

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2

Schneller, Stewart W., Xing Chen, and Suhaib M. Siddiqi. "Carbocyclic 7-Deazaguanosine Nucleosides as Antiviral Agents." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_8.

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3

Nair, Vasu. "Approaches to Novel Isomeric Nucleosides as Antiviral Agents." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_7.

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4

Fox, J. J., K. A. Watanabe, T. C. Chou, et al. "Antiviral Activities of 2′-Fluorinated Arabinosyl—Pyrimidine Nucleosides." In ACS Symposium Series. American Chemical Society, 1988. http://dx.doi.org/10.1021/bk-1988-0374.ch010.

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5

Van Roey, Patrick, and Chung K. Chu. "Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_15.

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6

Prisbe, Ernest J., Hans Maag, Julien P. H. Verheyden, and Robert M. Rydzewski. "Structure-Activity Relationships Among HIV Inhibitory 4′-Substituted Nucleosides." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_5.

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7

Matsuda, Akira, Atsushi Azuma, Yuki Nakajima, et al. "Design of New Types of Antitumor Nucleosides: The Synthesis and Antitumor Activity of 2′-Deoxy-(2′-C-Substituted)Cytidines." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_1.

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8

Lin, Tai-Shun, and Mao-Chin Liu. "Synthesis and Anticancer and Antiviral Activity of Certain Pyrimidine Nucleoside Analogues." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_10.

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9

Nasr, Mohamed, and Steven R. Turk. "Structure-Activity Correlations of 2′,3′-Dideoxy- and 2′,3′-Didehydro-2′,3′-Dideoxypyrimidine Nucleosides as Potential Anti-HIV Drugs." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_11.

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10

Beach, J. Warren, Lak S. Jeong, Hea O. Kim, S. Nampalli, K. Shanmuganathan, and Chung K. Chu. "Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides." In Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2824-1_12.

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Conference papers on the topic "Nucleosides Antiviral nucleosides"

1

Sergeant, Craig, Jan Balzarini, and Roman Dembinski. "Antiviral activity of 5-halofuropyrimidine nucleosides." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414209.

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LIU, Rong, and Shanshan GONG. "Synthesis of Dinucleoside Triphosphates Containing Antiviral Nucleoside." In International Conference on Biological Engineering and Pharmacy 2016 (BEP 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/bep-16.2017.45.

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3

Hostetler, Karl Y., and James R. Beadle. "Orally active lipid esters of antiviral nucleoside phosphonates." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507095.

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4

Mackman, R. L., C. G. Boojamra, J. Chen, et al. "Synthesis and antiviral activity of 4'-modified carbocyclic nucleoside phosphonates (CNPs)." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810191.

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Khandazhinskaya, Anastasia L., Elena A. Shirokova, Eugene A. Kataev, et al. "A new group of nucleoside mimics: Chemical synthesis and antiviral properties." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507409.

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Too, Kathleen, Daniel M. Brown, and David Loakes. "Mutagenic nucleoside analogues for use as antivirals by error catastrophe." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507315.

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Krasnoshtanova, Alla, and Elisaveta Borovkova. "OBTAINING NUCLEIC ACID PREPARATIONS AND THEIR HYDROLYSATES FROM BIOMASS OF METHANE-OXIDIZING BACTERIA." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/14.

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"Due to the unfavourable environmental, social and economic situation, the need for the treatment of oncological diseases and diseases associated with impaired activity of the immune system is increasing. A lot of these drugs are made on the basis of nucleic acid components, the industrial production of which is practically non-existent in Russia. Therefore, a task of current interest is to develop the basis of the technology for obtaining components of nucleic acids, which can be widely used in medicine as immunomodulatory, wound-healing, antiviral, and diagnostic medicine, as well as for can

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Hamann, Marie, Claire Pierra, Jean-Pierre Sommadossi, et al. "Synthesis and antiviral evaluation of 7,9-dideaza-8-thiapurine C-nucleoside derivatives." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810347.

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Holý, Antonín. "Synthetic approaches to "opened-ring" acyclic nucleoside phosphonates – novel type of antivirals." In XIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205027.

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Hosmane, Ramachandra, Maria Bretner, and Huanming Chen. "Base-Pairing Studies of a Ring-Expanded ("Fat") Nucleoside Analogue Possessing Potent Antiviral Activity." In The 3rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1999. http://dx.doi.org/10.3390/ecsoc-3-01744.

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Reports on the topic "Nucleosides Antiviral nucleosides"

1

Neenan, John P. Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents. Defense Technical Information Center, 1987. http://dx.doi.org/10.21236/adb124358.

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Walker, Richard T. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/ada229411.

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