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Dissertations / Theses on the topic ''-nucleotidase'

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Published: 4 June 2021

Last updated: 20 February 2023

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1

SIEGFRIED, GERALDINE. "Modulation de l'activite 5'-nucleotidase tubulaire renale." Paris 7, 1996. http://www.theses.fr/1996PA077134.

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Dans le rein, la 5'-nucleotidase est principalement localisee au niveau de la bordure en brosse apicale des cellules tubulaires proximales. Elle est ancree dans le feuillet membranaire externe par un glycosyl-phosphatidyl-inositol. Elle est l'enzyme cle d'une cascade faisant intervenir diverses ectoenzymes conduisant a la formation d'adenosine par l'hydrolyse des nucleotides adenyliques (atp, adp, et ampc). La degradation de l'ampc extracellulaire luminal suivie de la capture d'adenosine sont indispensables a l'effet inhibiteur de l'ampc extracellulaire sur la reabsorption proximale de phospha

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2

Roever, Lisa. "Inhibitor Studies for 5’-ecto-nucleotidase (CD73)." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1553892946798977.

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3

Zanin, Rafael Fernandes. "Investigação das ectonucleotidases na diferenciação de macrófagos e na ativação de plaquetas : o papel da homocisteína." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/61004.

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Os nucleotídeos extracelulares modulam uma variedade de ações biológicas via ativação de receptores purinérgicos. Esses efeitos são controlados pela ação de ectonucleotidases, tais como as E-NTPDases e a ecto-5´-NT/CD73, as quais hidrolisam o ATP até adenosina no meio extracelular. Nas células imunes, o ATP pode atuar como uma molécula sinalizadora de perigo enquanto a adenosina, um produto da degradação do ATP, serve como um mecanismo que controla/limita a inflamação. Já, no sistema vascular, o ADP é um agonista fisiológico envolvido na hemostasia normal e na trombose. Considerando que os mac

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4

ZEKRI, MUSTAPHA. "Heterogeneite structurale et fonctionnelle de la 5-nucleotidase." Nantes, 1990. http://www.theses.fr/1990NANT2056.

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La 5-nucleotidase cytosolique de foie de buf a ete purifiee a l'homogeneite par une double chromatographie d'affinite sur concanavaline a sepharose, puis 5-amp sepharose. L'enzyme purifie est un heterodimere de 130000 daltons avec deux sous-unites de 57000 et 65000 daltons, contrairement a l'isoenzyme membranaire qui presente une structure homodimerique (140000 daltons). L'enzyme hydrolyse specifiquement les 5-mononucleotides et le 5-cmp serait son meilleur substrat. Son activite maximale intervient a ph 7,5 et 9,5, et necessite l'apport de cations divalents exogenes. Par contre, la 5-nucleoti

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5

Bavaresco, Luci. "Estudo do papel da ecto-5'-nucleotidase/CD73 na proliferação de gliomas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/12713.

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Os gliomas são os tumores primários mais comuns e devastadores que atingem o sistema nervoso central. O prognóstico para pacientes com estes tumores é ruim, e apesar de intensos esforços para o desenvolvimento de novas terapias, agentes efetivos ainda não estão disponíveis. A ecto-5‟-nucleotidase/CD73 (ecto-5‟-NT/CD73) regula os níveis extracelulares de AMP e adenosina, a qual tem sido amplamente descrita como fator indutor de proliferação celular. A ecto-5‟-NT/CD73 per se tem sido relatada como proteína envolvida no controle dos processos de crescimento, maturação, diferenciação, invasão e mi

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6

Knöfel, Thomas. "Röntgenstrukturanalyse der 5'-Nucleotidase aus Escherichia coli mit dinuklearem Metallzentrum." [S.l. : s.n.], 2000. http://www.diss.fu-berlin.de/2000/131/index.html.

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7

Osborne, Foy Naomi. "Over-Expression of Ecto-5'-Nucleotidase in Pig Endothelial Cells." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487200.

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Ecto-5'-nucleotidase (E5'N) is an endothelial surface enzyme that controls conversion of extracellular nucleotides into immunosuppressive adenosine. Species differences and especially lO-fold higher activity of E5'N in human endothelial cells (EC) than in pig EC could be important barrier for xenotransplantation.The major aim ofmy thesis is evaluation whether expression of human E5'N on pig EC is able to attenuate cell death mediated by components ofhuman blood responsible for delayed xenograft rejection (DXR). A pig cell line was transfected with human E5'N and efficiency assessed with flow c

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8

McMillen, Lyle, and l. mcmillen@sct gu edu au. "Isolation and Characterisation of the 5'-Nucleotidase from Escherichia coli." Griffith University. School of Biomolecular and Biomedical Science, 2001. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030226.153545.

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Escherichia coli 5'-nucleotidase is a periplasmically localised enzyme capable of hydrolysing a broad range of substrates, including all 5'-ribo- and 5'-deoxyribonucleotides, uridine diphosphate sugars, and a number of synthetic substrates such as bis (r-nitrophenyl) phosphate. The enzyme has been shown to contain at least one zinc ion following purification, and to have two metal binding sites in the catalytic cleft. 5'-Nucleotidase activity is significantly stimulated by the addition of particular divalent metal ions, most notably cobalt which results in a 30-50 fold increase in activity.

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9

黎錦明 and Kam-ming Lai. "Structure and function of 5'-nucleotidase of the rat brain." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31232280.

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10

Saraiva, Antonio Marcos. "Caracterização funcional e estrutural da nucleotidase SurE de Xyllela fastidiosa." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316474.

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Orientador: Anete Pereira de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-14T21:21:36Z (GMT). No. of bitstreams: 1 Saraiva_AntonioMarcos_D.pdf: 12032714 bytes, checksum: 1262a05ca10735e855fa138a2093d04b (MD5) Previous issue date: 2009<br>Resumo: A linhagem 9a5c da bactéria Xylella fastidiosa foi o primeiro fitopatógeno a ter seu genoma completamente sequenciado, o qual gerdu diversas informações sobre seu metabolismo e patogenicidade. Das orfs codificadas por esta bactéria, destaca-se; no presente trabalho, a XF07

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11

Eristi, Can M. "Investigation of Transcriptional Regulation of 5'-Nucleotidase in Dictyostelium Discoideum." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/28822.

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A 5' AMP-degrading activity appears during the course of development in Dictyostelium discoideum between the prestalk and prespore zones. This enzyme is referred as 5'-Nucleotidase (5NT). Given the critical role of cyclic AMP in cell differentiation in this organism, 5NT is thought to be involved in cell positioning during development. Southern blot analysis showed a single form of the gene. The expression of the 5nt gene is known to be developmentally regulated. The message appears first at about 5 hr of the Dictyostelium development and remains constant throughout the rest of the develo

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12

Lai, Kam-ming. "Structure and function of 5'-nucleotidase of the rat brain /." [Hong Kong : University of Hong Kong], 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12986343.

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13

McMillen, Lyle. "Isolation and Characterisation of the 5'-Nucleotidase from Escherichia coli." Thesis, Griffith University, 2001. http://hdl.handle.net/10072/366487.

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Escherichia coli 5'-nucleotidase is a periplasmically localised enzyme capable of hydrolysing a broad range of substrates, including all 5'-ribo- and 5'-deoxyribonucleotides, uridine diphosphate sugars, and a number of synthetic substrates such as bis (r-nitrophenyl) phosphate. The enzyme has been shown to contain at least one zinc ion following purification, and to have two metal binding sites in the catalytic cleft. 5'-Nucleotidase activity is significantly stimulated by the addition of particular divalent metal ions, most notably cobalt which results in a 30-50 fold increase in activity.

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14

Silva, Eduardo de Almeida Marques da. "Influência do metabolismo extracelular de ATP em infecções por parasitos do gênero leishmania." Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa e Pós Graduação, Universidade Federal de Ouro Preto, 2008. http://www.repositorio.ufop.br/handle/123456789/2553.

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Submitted by Maurílio Figueiredo (maurilioafigueiredo@yahoo.com.br) on 2013-03-13T19:56:47Z No. of bitstreams: 1 TESE_InfluênciaMetabolismoExtracelular.PDF: 1475554 bytes, checksum: 99839ae26ebfc2a908a5ac279c901e2b (MD5)<br>Approved for entry into archive by Neide Nativa (neide@sisbin.ufop.br) on 2013-03-15T15:59:45Z (GMT) No. of bitstreams: 1 TESE_InfluênciaMetabolismoExtracelular.PDF: 1475554 bytes, checksum: 99839ae26ebfc2a908a5ac279c901e2b (MD5)<br>Made available in DSpace on 2013-03-15T15:59:45Z (GMT). No. of bitstreams: 1 TESE_InfluênciaMetabolismoExtracelular.PDF: 1475554 bytes, che

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15

Carrique, Loic. "Études des relations structure-fonctionactivité d’enzymes de Plasmodium falciparum pour la conception et la synthèse de nouvelles molécules antipaludiques." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1109.

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Plasmodium falciparum est responsable de la forme la plus grave de paludisme avec plus de 600 000 décès par an. L'absence de vaccin efficace, combinée à l'émergence de résistances aux traitements récurrents, exige le développement de nouvelles molécules. Afin de limiter ces résistances, il est nécessaire de cibler de nouvelles voies métaboliques indispensables à la survie du parasite. Ce travail de thèse repose sur l'étude de deux voies métaboliques essentielles au parasite que sont la voie de recyclage des bases puriques et la voie de biosynthèse des ancres glycosylphosphatidylinositol (GPI).

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Aubry, Jacques. "Etude fonctionnelle et enzymatique de la membrane plasmique de plasmocytome murin." Nantes, 1989. http://www.theses.fr/1989NANT01VS.

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17

Sopwith, William. "The cloning and characterization of the 3'-nucleotidase/nuclease in Leishmania Mexicana." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367753.

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18

Henn, Martina. "Role of Ecto-5'-nucleotidase in protection against gastrointestinal ischemia / reperfusion injury." [S.l. : s.n.], 2008.

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19

Chanchao, Chanpen. "The Role of 5' Nucleotidase in the Regulation of Morphogenesis in Dictyostelium Discoideum." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/28184.

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The Role of 5<sup>â </sup> Nucleotidase in the Regulation of Morphogenesis in <i>Dictyostelium</i> Chanpen Chanchao (ABSTRACT) 5<sup>â </sup> Nucleotidase (5NU) in <i>Dictyostelium discoideum</i> is an enzyme that shows high substrate specificity to 5<sup>â </sup>AMP. The enzyme has received considerable attention in the past because of the critical role played by cyclic AMP in cell differentiation in this organism. Degradation of cAMP by cAMP phosphodiesterase (PDE) produces 5<sup>â </sup>AMP, the substrate of 5NU. Dictyostelium switches its genetic program from growth to cellula

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20

Berti, Simone Luisa. "Efeitos da fenilalanina, fenilpiruvato e alanina sobre as atividades da ATP-difosfoidrolase (EC 3.6.1.5) e 5þ-nucleotidase (EC 3.1.3.5) em sinaptossomas de córtex cerebral de ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2000. http://hdl.handle.net/10183/81888.

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Estudos anteriores realizados no Laboratório de Erros Inatos do Metabolismo demonstraram que fenilalanina (Phe) 2,0 mM ou fenilpiruvato (PP) 5,0 mM, um metabólito desaminado da Phe, reduzem a atividade da ATP-difosfoidrolase em sinaptossomas de córtex cerebral de ratos. Já estudos do efeito da Phe e do fenilactato sobre a atividade da Na+K+-ATPase, enzima envolvida na manutenção do potencial de membrana e na integridade celular no cérebro, demonstraram seus efeitos inibitórios, bem como a reversão destes efeitos pela alanina (Ala), competitivamente. Por outro lado, quando testada isoladamente,

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Rahimova, Rahila. "Structure-based drug design of allosteric ecto-5'-nucleotidase inhibitors : application to cancer treatment." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT039.

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Le cancer représente l'un des problèmes majeurs en santé publique. Jusqu'à présent, en parallèle de l'intervention chirurgical, plusieurs traitements ont été mis au point et largement utilisés en thérapie clinique telles que les chimiothérapies. Cependant, leur efficacité est parfois limitée et couplée à des effets secondaires très néfastes, laissant les patients dans une impasse thérapeutique. Par conséquent, de nouvelles approches thérapeutiques doivent être développées sur de nouvelles cibles avérées en oncologie afin d'apporter des soins personnalisés aux patients. La première partie de mo

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Rockenbach, Liliana. "Caracterização da ecto-5'-nucleotidase e da NTPDase3 na progressão do câncer de bexiga." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/151318.

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O câncer de bexiga é a segunda neoplasia urogenital mais comum, atinge mais os homens e está relacionado principalmente com o fumo. Os tratamentos atualmente utilizados não são suficientemente efetivos, permitindo os diversos casos de recorrência, progressão do tumor e/ou morte do paciente. Assim, as pesquisas realizadas continuam buscando tratamentos mais efetivos. Diversos estudos revelam o envolvimento do sistema purinérgico na tumorigênese da bexiga, no âmbito das ectonucleotidases, há evidências de alterações em duas delas na progressão do câncer de bexiga: a NTPDase3 e a ecto-5’-NT/CD73.

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Stutzer, Christian. "Molecular characterisation of two Ornithodoros savignyi enzyme isoforms belonging to the 5'-nucleotidase family." Diss., Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-01282009-171755.

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Slater, Nataliya. "In vitro selection of DNA aptamers that neutralise autoantibodies to cytosolic 5’-nucleotidase-1A." Thesis, Slater, Nataliya (2019) In vitro selection of DNA aptamers that neutralise autoantibodies to cytosolic 5’-nucleotidase-1A. Honours thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/54117/.

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Background. Inclusion Body Myositis (IBM) is the most commonly diagnosed inflammatory muscle disease associated with aging. It’s characterised by degeneration of skeletal muscles that inevitably leads to the loss of mobility. The mechanisms that drive IBM pathogenicity remain poorly understood. However, studies reveal that on average 50% of IBM sera contains circulating autoantibodies targeting cytosolic 5’-nucleotidase 1A (cN1A) – a metabolic enzyme that is highly expressed in skeletal muscles. Accumulating evidence suggests that anti-cN1A antibodies may play a role in IBM pathogenesis making

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Santos, Clelton Aparecido dos 1984. "Estudos estruturais e funcionais de proteínas relacionadas à patogenicidade de Xylella fastidiosa." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316504.

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Orientadores: Anete Pereira de Souza, Ricardo Aparício<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-22T00:47:17Z (GMT). No. of bitstreams: 1 Santos_CleltonAparecidodos_D.pdf: 17722787 bytes, checksum: bfe46a8c0582a66be16a3f8b35fc9ada (MD5) Previous issue date: 2013<br>Resumo: Xylella fastidiosa é uma bactéria responsável por inúmeras doenças de plantas em culturas economicamente importantes ao redor do mundo, incluindo a clorose variegada dos citros. Após a infecção de seu hospedeiro, as células de X. fastidiosa é apta

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Wiles, Natasha Shawn. "Identification of Regulatory Binding Sites and Corresponding Transcription Factors Involved in the Developmental Control of 5'-nucleotidase Expression in Dictyostelium discoideum." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27810.

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Gene regulation is a critical aspect of normal development, energy conservation, metabolic control, and responses to environmental cues, diseases and pathogens in eukaryotic organisms. In order to appropriately respond to environmental changes and advance through the life cycle, an organism must manage the expression levels of a large number of genes by utilizing available gene regulation mechanisms. The developmental control of 5â -nucleotidase (5nt) expression in the model system Dictyostelium discoideum has provided a focal point for studies of gene regulation at the level of transcription

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Freundlieb, Marianne [Verfasser]. "Entwicklung und Charakterisierung von neuen und selektiven Inhibitoren für die Ecto-5'-Nucleotidase / Marianne Freundlieb." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1136955186/34.

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Leal, Cláudio Alberto Martins. "ATIVIDADE DAS ENZIMAS NTPDASE E 5 - NUCLEOTIDASE EM PLAQUETAS DE GESTANTES NORMAIS E DE ALTO RISCO." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/5916.

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Hemostasis is a complex process that involves equilibrium between the coagulation and fibrinolytic systems. Furthermore, the spatial and temporal expression of NTPDases in the vasculature appears to control platelet activation, thrombus size and stability, by regulating phosphohydrolytic activity and consequent P2 receptor signaling. Here we show the activity of ectonucleotidases on the platelet surface of normal pregnant women and pregnant women with complications. The activities of the enzymes, NTPDase and 5 - nucleotidase, were analyzed in the platelets of four patient groups composed of w

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Wietersheim, Simone Corinna von. "Erythropoetin-Sekretion bei Ekto-5-Nukleotidase (CD 73)- Knockout Mäusen." [S.l. : s.n.], 2007.

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Crichton, David Noble. "Studies on the ectoenzyme 5'-nucleotidase (EC 3.1.3.5) in relation to human lymphocyte development and function." Thesis, University of Edinburgh, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335809.

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Kagami, Luciano Porto. "Estudo in silico de novas diidropirimidin-2-tionas com ação inibitória da enzima ecto-5'-nucleotidase." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/170643.

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Os tumores cerebrais primários mais comuns são os gliomas. Os gliomas representam 31% de todos os tumores cerebrais diagnosticados nos Estados Unidos sendo 81% destes tumores malignos. O glioblastoma (GBM) é o tumor mais comum entre os gliomas, sua taxa de incidência varia de 0,59 a 3,69 a cada 100.000 pessoas, dependendo da idade e do país. A ecto-5’-nucleotidase regula os níveis extracelulares de AMP e adenosina, a qual tem sido amplamente descrita como fator indutor de proliferação celular. Estudos demonstraram que a atividade da enzima ecto-5’-nucleotidase foi aumentada em linhagens de cél

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Mendes, Franciane Brackmann. "α-bisabolol e óxido de bisabolol A : atividade antitumoral em linhagens celulares de cânceres do sistema nervoso central". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/103251.

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Diversas neoplasias podem atingir o sistema nervoso central e dentre elas, os tumores cerebrais são os mais prevalentes. Dentre todos os tumores cerebrais, dois merecem especial atenção: gliomas e meduloblastomas, por serem os mais recorrentes em adultos e crianças, respectivamente. O alfa-bisabolol é um pequeno álcool sesquiterpeno oleoso, que apresenta diversas atividades biológicas dentre elas, citotoxicidade. Apesar dos diversos estudos com essa molécula, pouco se sabe das atividades biológicas de seu análogo natural, o óxido de bisabolol A. Além disso, o sistema purinérgico tem sido relac

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Oliveira, Camila Belmonte. "Atividade das enzimas ntpdase, 5´-nucleotidase e adenosina deaminase em plaquetas de ratos infectados por Trypanosoma evansi." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/10079.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Nucleotide- and nucleoside-degrading enzymes are present in the surface of platelets, blood cells involved in clotting disturbances of Trypanosoma evansi-infected animals. Thus, this study was aimed at evaluating the activity of the enzymes NTPDase, 5 - nucleotidase and adenosine deaminase in platelets of rats experimentally infected by T. evansi. Animals were divided into four groups, according to the degree of parasitemia. Samples were collected at days 3 (group A: at the beginning of parasitemia), 5 (group B: high parasite

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Braganhol, Elizandra. "Quercetina : efeitos sobre parâmetros proliferativos e sobre a ecto-5'-nucleotidase em linhagem de glioma humano U138MG." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/6714.

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Gliomas são os mais comuns e devastadores tumores primários do sistema nervoso central. Os nucleotídeos da adenina são moléculas sinalizadoras no meio extracelular, envolvidas em importantes condições fisiológicas e patológicas. O ATP, neurotransmissor excitatório, e a adenosina, neuromoduladora, entre outros efeitos, podem induzir proliferação celular em linhagens de gliomas. Os eventos induzidos pelos nucleotídeos extracelulares são controlados pela ação das E-NTPDases, que hidrolisam o ATP até adenosina extracelularmente. Recentes estudos epidemiológicos têm sugerido que os flavonóides deri

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Medeiros, Liciane Fernandes. "Efeito da administração de anestésicos gerais, associado ou não ao procedimento cirúrgico, sobre : parâmetros comportamentais, atividades E-NTPdásica e de ecto-5'nucleotidase em medula espinhal de ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/23757.

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Devido a dificuldades técnicas de modelagem experimental e de aferição de dor, até os anos 70, acreditava-se que recém-nascidos e lactentes jovens não teriam maturidade neurológica para conduzir, de forma adequada, os estímulos dolorosos; portanto, não sentiam dor. Recentes estudos, focados na área de neurobiologia do desenvolvimento, têm demonstrado como as informações sensoriais são processadas no início da vida e que dor intensa ou persistente no prematuro ou neonato pode provocar alterações de comportamento e percepção da dor que podem persistir no decorrer da vida. Considerando a relevânc

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Cappellari, Angélica Regina. "Efeito de diferentes componentes da matriz extracelular sobre a ecto-5'-nucleotidase, proliferação, adesão e migração celular na linhagem de células de glioma humano U138-MG." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13847.

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Glioblastoma multiforme é a forma mais comum e agressiva de tumor cerebral que apresenta um severo crescimento e um comportamento altamente invasivo. Linhagens de células de glioma em cultura apresentam alta atividade da enzima ecto-5’-nucleotidase que metaboliza AMP em adenosina. Em adição, ela também interage com componentes da matriz extracelular como molécula adesiva. Neste trabalho, nós avaliamos o efeito de diferentes componentes da matriz extracelular sobre a atividade da ecto-5’-nucleotidase, proliferação, adesão e migração celular na linhagem de células de glioma humano U138-MG. Os re

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Costa, Pauline da. "Atividade da NTPDase, 5 -nucleotidase, acetilcolinesterase e níveis de peroxidação lipídica em ratos expostos ao cádmio e tratados com curcumina." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11243.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Cadmium (Cd) is one of the most toxic metals in relation to environmental contamination and human poisoning. This metal has a long biological half-life (10-30 years) and prolonged exposure to Cd has been associated with toxic effects on many organs as kidneys, liver, lungs, bone, including the brain, probably due to generation of stress oxidative. In this context, it is known that the polyphenol curcumin, natural compound derived from Curcuma longa, exerce several therapeutic functions, highlighting the great antioxidant, anti-in

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Rodrigues, Marília Valvassori. "EFEITOS DA VD3 SOBRE A MEMÓRIA E SOBRE O SISTEMA PURINÉRGICO E COLINÉRGICO EM UM MODELO DE DEMÊNCIA ESPORÁDICA DO TIPO ALZHEIMER EM RATOS." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11244.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Alzheimer's disease (AD) is considered the main cause of dementia in elderly people worldwide. This disease affects the central nervous system (CNS), especially the cerebral cortex and hippocampus, areas that are responsible for the processes of learning and memory, for this the search for new therapies to treat this condition is constant. Studies indicate that Vitamin D3 (VD3) may be involved in the functions of neurotransmission, neuroprotection and neuroimmunomodulation in different brain processes, in addition to being involved

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Dias, Glaecir Roseni Mundstock. "EFEITO AGUDO E CRÔNICO DO ETANOL SOBRE AS ENZIMAS NTPDase, 5'-NUCLEOTIDASE, ACETILCOLINESTERASE, PEROXIDAÇÃO LIPÍDICA E COMPORTAMENTO EM RATOS." Universidade Federal de Santa Maria, 2004. http://repositorio.ufsm.br/handle/1/11089.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Ethanol is one of the most used substance in different societies. This study was performed in order to clarify the acute and chronic effects of ethanol on biochemical and behavioral parameters in male Wistar rats. The acute treatment consisted of oral administration by gavage of 0.8, 2.0, 4.0, 6.0 and 8.0 g ethanol/kg. All rats were sacrificed one hour and thirty minutes post treatment. The results showed that acute treatment induced a biphasic or hormetic effect in platelet NTPDase and 5'-nucleotidase activities. The activity of

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Gruenewald, Jana Katrin Gesine. "Mechanisms involved in leukocyte transendothelial migration : studies of the role of hydrogen peroxide and the ecto-5'-nucleotidase, CD73." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1443960/.

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During inflammation, leukocytes are recruited from blood vessels into the site of injury or infection. A key event in this process is transendothelial migration (TEM), a multi-step process involving various adhesion molecules on both leukocytes and endothelial cells. Oxidative stress has been linked to inflammation in the development of various diseases. To investigate the effect of oxidative stress on TEM, leukocytes were treated with hydrogen peroxide (H2O2). A defect in TEM was observed across human umbilical vein endothelial cells (HUVECs), but not across a porous membrane, suggesting that

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Silva, Adriane Cismoski da. "Estudo da atividade das enzimas NTPDase e 5'-nucleotidase e do perfil oxidativo em pacientes com insuficiência renal crônica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13547.

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As anormalidades hemostáticas são comumente encontradas em pacientes com doença renal. Ambos, sangramento e estados pró-trombóticos, podem ser observados em pacientes com doença renal crônica (DRC). O principal papel das plaquetas é assegurar a hemostasia primária, a manutenção da integridade do vaso e cessar o sangramento após uma injúria. As plaquetas também estão envolvidas na trombose arterial aguda, na inflamação, na aterosclerose, e na angiogênese. Quando as plaquetas são ativadas elas se aderem à matrix endotelial onde ocorre a ativação e a liberação de agonistas secundários tais como o

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Ledoux, Séverine. "Ecto-5'-Nucléotidase : fonctions et régulation dans le rein et l'endothélium." Paris 7, 2002. http://www.theses.fr/2002PA077106.

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Bhattarai, Sanjay [Verfasser]. "Synthesis and structure-activity relationships of alpha,beta-methylene-ADP derivatives: potent and selective ecto-5′-nucleotidase inhibitors / Sanjay Bhattarai." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077290330/34.

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Santiago, Paula Beatriz. "Análise proteômica revela que a saliva de Dipetalogaster maxima é rica em lipocalinas e possui apirase da família 5’ nucleotidase." reponame:Repositório Institucional da UnB, 2011. http://repositorio.unb.br/handle/10482/8485.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, 2011.<br>Submitted by Matheus Denezine (matheusdenezine@yahoo.com.br) on 2011-06-20T14:02:41Z No. of bitstreams: 1 2011_PaulaBeatrizdeMedeirosSantiago.pdf: 11948167 bytes, checksum: 2c8b46d29088a72eb877776e2587dc84 (MD5)<br>Approved for entry into archive by Daniel Ribeiro(daniel@bce.unb.br) on 2011-06-20T18:48:34Z (GMT) No. of bitstreams: 1 2011_PaulaBeatrizdeMedeirosSantiago.pdf: 11948167 bytes, checksum: 2c8b46d29088a72eb877776e2587dc84 (MD5)<br>Made available in DSpace on 2011-06-20T18:48:34Z (GMT). No. of bitstream

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Bona, Karine Santos de. "EFEITO DO EXTRATO DE SYZYGIUM CUMINI, IN VITRO, NA ATIVIDADE DE ENZIMAS QUE DEGRADAM NUCLEOTÍDEOS E NUCLEOSÍDEOS DE ADENINA E ÉSTERES DE COLINA E SOBRE O PERFIL OXIDATIVO EM PACIENTES COM DIABETES MELLITUS TIPO 2." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/5923.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia resulting from deficiency of production and / or insulin action. This state of hyperglycemia may cause a variety of cardiovascular, renal, neurological and eye complications. Adenosine deaminase (ADA), ecto-5 'nucleotidase (5'NT) and Acetylcholinesterase (AChE) are important enzymes responsible for regulating the levels of adenosine (ado) and acetylcholine (ACh) respectively, and changes in their activities have been demonstra

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Falk, Melanie. "Evaluation of a novel model of cardiac ischemic preconditioning and role of ecto-5'-nucleotidase in ischemic preconditioning of the heart /." Tübingen, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254316.

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Mehul, Bruno. "Mise en evidence et role d'une interaction laminine-ecto-5'-nucleotidase au cours du developpement du muscle srtie chez le poulet." Paris 5, 1992. http://www.theses.fr/1992PA05S013.

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La 5'-nucleotidase ecto-membranaire (5'-n) dephosphoryle le 5'-amp. Par differentes approches methodologiques in vivo et in vitro, il nous a ete possible de mettre en evidence d'une part, une heterogeneite de la 5'-n entre le muscle strie, cardiaque et lisse de gesier de poulet (notamment en ce qui concerne son activite enzymatique au cours du developpement) ainsi que la presence de formes ancrees par un phosphatidyl inositol glycanne qui pourrait coexister avec des formes transmembranaires interagissant avec le cytosquelette ; hypothese renforcee par la presence de 5'-n dans les jonctions ten

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Barz, Malwine Jeanette [Verfasser]. "Clinical and biological relevance of mutations in the cytosolic 5´-nucleotidase II (NT5C2) gene in children with relapsed acute lymphoblastic leukemia / Malwine Jeanette Barz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223925587/34.

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Schmatz, Roberta. "Efeito do resveratrol nos sistemas colinérgico e purinérgico em encéfalo de ratos diabéticos." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/11106.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Diabetes mellitus is a major public health problem throughout the world. Besides the most common complications in the peripheral nervous system, diabetes may also cause a series of cognitive, structural and functional alterations in the central nervous system (CNS). Acetylcholinesterase (AChE), NTPDase and 5 -nucleotidase are important enzymes involved in neurotransmission and alterations in their activities have been observed in various diseases including diabetes. Resveratrol is a polyphenol abundant in grapes and red wine tha

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Nazario, Luiza Reali. "Estudo do papel da ecto-5'-nucleotidase no contexto da inflama??o avaliando par?metros citol?gicos, bioqu?micos, moleculares e imagens de ?PET/CT em Zebrafish." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2016. http://tede2.pucrs.br/tede2/handle/tede/6927.

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Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-08-25T16:23:46Z No. of bitstreams: 1 DIS_LUIZA_REALI_NAZARIO_PARCIAL.pdf: 804114 bytes, checksum: d4d4d3525f9a5a4a62c1c8080197776f (MD5)<br>Made available in DSpace on 2016-08-25T16:23:46Z (GMT). No. of bitstreams: 1 DIS_LUIZA_REALI_NAZARIO_PARCIAL.pdf: 804114 bytes, checksum: d4d4d3525f9a5a4a62c1c8080197776f (MD5) Previous issue date: 2016-03-21<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Funda??o de Amparo ? Pesquisa do Estado do Rio Grande do Sul - FAPERGS<br>The LPS mechanism

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