Academic literature on the topic 'Nucleotides binding'

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Journal articles on the topic "Nucleotides binding"

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McIlroy, Patrick J. "Effects of cations on binding of human choriogonadotropin." Biochemistry and Cell Biology 66, no. 12 (December 1, 1988): 1258–64. http://dx.doi.org/10.1139/o88-145.

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The effect of various salts on the binding of human choriogonadotropin to rat luteal membranes has been examined. Increasing salt concentrations had biphasic effects, initially increasing binding, then decreasing it. With NaCl, these effects were on both the affinity and the number of receptor sites. The affinity increased with increasing NaCl concentrations, to a maximum at 40 mM, and then decreased. Above 40 mM NaCl, the number of binding sites increased. NaCl also altered the effects of Mg2+ and guanyl nucleotides. At low ionic strength, Mg2+ was necessary to observe binding. Guanine nucleo
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Hause, Lara L., and Kevin S. McIver. "Nucleotides Critical for the Interaction of the Streptococcus pyogenes Mga Virulence Regulator with Mga-Regulated Promoter Sequences." Journal of Bacteriology 194, no. 18 (July 6, 2012): 4904–19. http://dx.doi.org/10.1128/jb.00809-12.

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ABSTRACTThe Mga regulator ofStreptococcus pyogenesdirectly activates the transcription of a core regulon that encodes virulence factors such as M protein (emm), C5a peptidase (scpA), and streptococcal inhibitor of complement (sic) by directly binding to a 45-bp binding site as determined by an electrophoretic mobility shift assay (EMSA) and DNase I protection. However, by comparing the nucleotide sequences of all established Mga binding sites, we found that they exhibit only 13.4% identity with no discernible symmetry. To determine the core nucleotides involved in functional Mga-DNA interactio
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Chander, Preethi, Kari M. Halbig, Jamie K. Miller, Christopher J. Fields, Heather K. S. Bonner, Gail K. Grabner, Robert L. Switzer, and Janet L. Smith. "Structure of the Nucleotide Complex of PyrR, the pyr Attenuation Protein from Bacillus caldolyticus, Suggests Dual Regulation by Pyrimidine and Purine Nucleotides." Journal of Bacteriology 187, no. 5 (March 1, 2005): 1773–82. http://dx.doi.org/10.1128/jb.187.5.1773-1782.2005.

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ABSTRACT PyrR is a protein that regulates the expression of genes and operons of pyrimidine nucleotide biosynthesis (pyr genes) in many bacteria. PyrR acts by binding to specific sequences on pyr mRNA and causing transcriptional attenuation when intracellular levels of uridine nucleotides are elevated. PyrR from Bacillus subtilis has been purified and extensively studied. In this work, we describe the purification to homogeneity and characterization of recombinant PyrR from the thermophile Bacillus caldolyticus and the crystal structures of unliganded PyrR and a PyrR-nucleotide complex. The B.
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Schulz, Georg E. "Binding of nucleotides by proteins." Current Opinion in Structural Biology 2, no. 1 (February 1992): 61–67. http://dx.doi.org/10.1016/0959-440x(92)90178-a.

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Schulz, Georg E. "Binding of nucleotides by proteins." Current Biology 2, no. 2 (February 1992): 81. http://dx.doi.org/10.1016/0960-9822(92)90208-r.

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Csanády, László, and Vera Adam-Vizi. "Antagonistic Regulation of Native Ca2+- and ATP-sensitive Cation Channels in Brain Capillaries by Nucleotides and Decavanadate." Journal of General Physiology 123, no. 6 (June 1, 2004): 743–57. http://dx.doi.org/10.1085/jgp.200309008.

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Regulation by cytosolic nucleotides of Ca2+- and ATP-sensitive nonselective cation channels (CA-NSCs) in rat brain capillary endothelial cells was studied in excised inside-out patches. Open probability (Po) was suppressed by cytosolic nucleotides with apparent KI values of 17, 9, and 2 μM for ATP, ADP, and AMP, as a consequence of high-affinity inhibition of channel opening rate and low-affinity stimulation of closing rate. Cytosolic [Ca2+] and voltage affected inhibition of Po, but not of opening rate, by ATP, suggesting that the conformation of the nucleotide binding site is influenced only
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Sullivan, S. M., R. Mishra, R. R. Neubig, and J. R. Maddock. "Analysis of Guanine Nucleotide Binding and Exchange Kinetics of the Escherichia coli GTPase Era." Journal of Bacteriology 182, no. 12 (June 15, 2000): 3460–66. http://dx.doi.org/10.1128/jb.182.12.3460-3466.2000.

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ABSTRACT Era is an essential Escherichia coli guanine nucleotide binding protein that appears to play a number of cellular roles. Although the kinetics of Era guanine nucleotide binding and hydrolysis have been described, guanine nucleotide exchange rates have never been reported. Here we describe a kinetic analysis of guanine nucleotide binding, exchange, and hydrolysis by Era using the fluorescent mant (N-methyl-3′-O-anthraniloyl) guanine nucleotide analogs. The equilibrium binding constants (KD ) for mGDP and mGTP (0.61 ± 0.12 μM and 3.6 ± 0.80 μM, respectively) are similar to those of the
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Lew, Chih M., and Jay D. Gralla. "Mechanism of Stimulation of Ribosomal Promoters by Binding of the +1 and +2 Nucleotides." Journal of Biological Chemistry 279, no. 19 (March 9, 2004): 19481–85. http://dx.doi.org/10.1074/jbc.m401285200.

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The rate of transcription ofEscherichia coliribosomal RNA promoters is central to adjusting the cellular growth rate to nutritional conditions. The +1 initiating nucleotide and ppGpp are regulatory effectors of these promoters. The data herein show thatin vitrotranscription is also regulated by the +2 nucleotide. Both the +1 and +2 nucleotides act by driving polymerase into an altered conformation rather than by increasing the lifetime of transcription complexes. The unique design of the ribosomal promoters may stabilize a distorted state of polymerase that is relieved by the binding of the tw
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Gromadski, Kirill B., Tobias Schümmer, Anne Strømgaard, Charlotte R. Knudsen, Terri Goss Kinzy та Marina V. Rodnina. "Kinetics of the Interactions between Yeast Elongation Factors 1A and 1Bα, Guanine Nucleotides, and Aminoacyl-tRNA". Journal of Biological Chemistry 282, № 49 (9 жовтня 2007): 35629–37. http://dx.doi.org/10.1074/jbc.m707245200.

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The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1Bα (eEF1Bα), guanine nucleotides, and aminoacyl-tRNA were studied kinetically by fluorescence stopped-flow. eEF1A has similar affinities for GDP and GTP, 0.4 and 1.1 μm, respectively. Dissociation of nucleotides from eEF1A in the absence of the guanine nucleotide exchange factor is slow (about 0.1 s–1) and is accelerated by eEF1Bα by 320-fold and 250-fold for GDP and GTP, respectively. The rate constant of eEF1Bα binding to eEF1A (107–108m–1 s–1) is independent of guanine nucleotides. At the
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Demeuse, Philippe, Reinhold Penner, and Andrea Fleig. "TRPM7 Channel Is Regulated by Magnesium Nucleotides via its Kinase Domain." Journal of General Physiology 127, no. 4 (March 13, 2006): 421–34. http://dx.doi.org/10.1085/jgp.200509410.

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TRPM7 is a Ca2+- and Mg2+-permeable cation channel that also contains a protein kinase domain. While there is general consensus that the channel is inhibited by free intracellular Mg2+, the functional roles of intracellular levels of Mg·ATP and the kinase domain in regulating TRPM7 channel activity have been discussed controversially. To obtain insight into these issues, we have determined the effect of purine and pyrimidine magnesium nucleotides on TRPM7 currents and investigated the possible involvement of the channel's kinase domain in mediating them. We report here that physiological Mg·AT
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Dissertations / Theses on the topic "Nucleotides binding"

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Herzog, Mario. "Thermophoresis and cooperative binding of nucleotides." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149751.

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Johansson, Kenth. "Structural studies of four nucleotide binding proteins : aldehyde dehydrogenase, NADP-malate dehydrogenase and two deoxynucleoside kinases /." Uppsala : Swedish University of Agricultural Sciences, 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009416200&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Kennedy, Eileen Jeanne. "Understanding modulation of nucleotide binding by PKA and regulation of extracellular nucleotides in saccharomyces cerevisiae /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208636.

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Worth, Graham Alan. "The energetics of nucleotide binding to RAS proteins." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:44524415-2f2b-4601-998c-56110f332153.

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Ras proteins are a special class of proteins that mediate cell growth signals. Their importance lies in the fact that they are products of a proto-oncogene. This means that under certain conditions the gene that determines its structure is altered and a mutant protein results that is involved in the transformation of normal cells to cancer cells. The actual function by which the protein acts in the signal pathway is not known. However it is known that they act as a switch, undergoing a cycle involving the exchange of guaninosine nucleotides in the binding site. This thesis uses computer simula
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Herzog, Mario [Verfasser], and Dieter [Akademischer Betreuer] Braun. "Thermophoresis and cooperative binding of nucleotides / Mario Herzog. Betreuer: Dieter Braun." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027669522/34.

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Law, Wing-lun, and 羅永倫. "Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46939118.

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Peake, Sarah Jayne. "Structure and function of the NADP(H)-binding component (dIII) of human heart transhydrogenase." Thesis, University of Birmingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367626.

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Jeans, David Richard. "Properties of the nucleotide binding sites of the Ca²⁺-ATPase of sarcoplasmic reticulum." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/26592.

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Properties of the nucleotide binding site of the Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum have been investigated. The study centred around interaction of the high affinity ATP analog, 2'-3'-0-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate, (TNP-ATP), with the Ca²⁺-ATPase. Defined fractions of the sarcoplasmic reticulum (SR), corresponding to the terminal cisternae (TC) and light SR (LSR), were isolated. The TC were shown to have distinctive morphological characteristics that differ from the LSR. The TC vesicles contained electron dense intravesicular material representative of Ca
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Montgomery, Kyle Everett. "MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/297.

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AMPA receptors mediate excitatory synaptic transmission throughout the central nervous system via activation by their natural agonist glutamate. Several other molecules have been recognized as receptor agonist or antagonist, and recently allosteric modulators have been developed that potentiate the currents generated by these receptors. The goal of this thesis has been to address specific and as yet unresolved questions regarding the binding interactions between the AMPA receptors and these classes of molecules. For instance AMPA receptors are seemingly converted to have lower affinity for ago
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Aung-Htut, May Thandar Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Characterisation of Escherichia coli GTPase Der reveals previously unknown regulation by RNA." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41840.

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GTPases are found in all domains of life and are highly conserved. In eukaryotes, they serve as signalling molecules for many cellular processes. However, the prokaryotic GTPases play a very different role and are found to be associated with ribosome function. Among the 11 conserved GTPases, Der is the most interesting in prokaryotes. It possesses a unique structure with two GTPase domains (G-Domains) tethered by a variable length acidic linker and a carboxyl terminal KH-like domain. The exact function of Der is still under investigation and most of the data suggest that it is important for 50
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Books on the topic "Nucleotides binding"

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Bosch, L., B. Kraal, and A. Parmeggiani, eds. The Guanine — Nucleotide Binding Proteins. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2037-2.

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EMBO-NATO-CEC Advanced Research Workshop on the Guanine-Nucleotide Binding Proteins: Common Structural and Functional Properties (1988 Renesse, Netherlands). The guanine-nucleotide binding proteins: Common structural and functional properties. New York: Plenum Press, 1989.

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Maurer, Brigitte. Expression and purification of the nucleotide binding domains of P-glycoprotein. Ottawa: National Library of Canada, 2001.

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Grondin, Ronald Thomas. Expression, purification, refolding, and ATP binding of the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Venning, Jamie Derrick. The catalytically-active complex of the nucleotide-binding domains of transhydrogenase from rhodospirillum rubrum. Birmingham: University of Birmingham, 1999.

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Taylor, Catherine Yvonne. Analysis of protein binding motifs in the nucleotide sequence of the human [gamma]-actin gene promoter. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.

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Stilwell, Shaun Nicholas. The involvement of NADP(H) binding and release in energy transduction by proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli and Rhodospirillum rubrum. Birmingham: University of Birmingham, 1997.

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NATO, Advanced Research Institute on Biological Signal Transduction (1990 Island of Spetsai Greece). Biological signal transduction. Berlin: Springer-Verlag, 1991.

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Photolabeling the nucleotide binding sites of dog kidney Na,K-ATPase with azido nucleotides. 1993.

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The Guanine - Nucleotide Binding Proteins:Common Structural and Functional Properties. Springer, 1989.

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Book chapters on the topic "Nucleotides binding"

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Dove, Stefan. "Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites." In Non-canonical Cyclic Nucleotides, 49–66. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/164_2015_34.

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Eccleston, J. F., T. F. Kanagasabai, D. P. Molloy, S. E. Neal, and M. R. Webb. "The Application of Fluorescent and Photosensitive Analogues of Guanine Nucleotides to the Function and Structure of G-Binding Proteins." In The Guanine — Nucleotide Binding Proteins, 87–97. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2037-2_9.

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Hankin, Joseph A., and Robert C. Murphy. "Covalent Binding of Leukotriene A4 to Nucleosides, Nucleotides, and Nucleic Acids." In Advances in Experimental Medicine and Biology, 29–33. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9194-2_7.

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Berden, Jan A., Cees M. Edel, and Aloysius F. Hartog. "Number, Localisation and Function of the Non-Catalytic Adenine Nucleotide Binding Sites of Mitochondrial F1-ATPase." In Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction, 47–58. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7315-4_4.

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Balobanov, V., N. Lekontseva, A. Mikhaylina, and A. Nikulin. "Use of Fluorescent Nucleotides to Map RNA-Binding Sites on Protein Surface." In Methods in Molecular Biology, 251–62. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0278-2_17.

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Sakurai, Hidehiro, and Toru Hisabori. "Characterization of Nucleotide Binding Sites on Chloroplast Coupling Factor 1 (CF1): Effects of Nucleotides on Nucleotide Triphosphate Formation by Isolated CF1." In Molecular Structure, Function, and Assembly of the ATP Synthases, 267–71. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0593-4_27.

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Moss, J., D. L. Burns, and M. Vaughan. "Mechanism of Action of Choleragen: Effect of Toxin on Binding of Guanyl Nucleotides." In Bacterial Diarrheal Diseases, 153–60. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-4990-4_15.

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Kitabgi, Patrick, and Jean-Pierre Vincent. "Effects of Cations and Nucleotides on Neurotensin Binding to Rat Brain Synaptic Membranes." In Neural and Endocrine Peptides and Receptors, 313–19. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5152-8_21.

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Shrestha, Rojan, Jisu Kim, and Kyungsook Han. "Prediction of RNA-Binding Residues in Proteins Using the Interaction Propensities of Amino Acids and Nucleotides." In Lecture Notes in Computer Science, 114–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-87442-3_16.

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Kaziro, Yoshito. "Structure and Function of G Proteins from Mammalian and Yeast Cells." In The Guanine — Nucleotide Binding Proteins, 291–304. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2037-2_29.

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Conference papers on the topic "Nucleotides binding"

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Sumi, Y., Y. Nakamura, M. Sakai, M. Muramatsu та N. Aoki. "STRUCTURE OF HUMAN α2-PLASMIN INHIBITOR DEDUCED FROM THAT OF cDNA". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644371.

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The complete amino acid sequence of α2-plasmin inhibitor (α2PI) was determined by cDNA cloning. A Agt 10 cDNA library was prepared from poly(A)+mRNA isolated from cultured human liver cells. The labeled oligonucleotides, corresponding to the reported partial amino acid sequences of α2PI, were used as probes to screen the library. One of the positive clones was subcloned into plasmid pUC8. A 2.2 kilobase cDNA clone thus isolated contains a region coding for a portion of a leader sequence, the mature protein, a stop codon (TGA), a 3' noncoding region (733 nucleotides), and a poly(A)tail (37 nucl
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Athayde, C. M., and M. C. Scrutton. "ROLE OF GUANINE NUCLEOTIDES IN Ca2+ - DEPENDENT LYSOSOMAL SECRETION FROM ELECTROPERMEABILISED PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644513.

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Previous studies have shown that the maximal extent of Ca2+ dependent secretion of β-N-acetylglucosaminidase (B-N-AcGlc) from electropermeabilised human platelets can be enhanced by addition of thrombin or of 1-oleyl-2-acetylglycerol or 12-0-tetradecanoyl phorbol-13-acetate without a significant alteration in the EC^q for Ca2+. (Knight et al. Europ. J. Biochem.,143337 (1984)). We have found a similar Ca2+ dependent increase in the maximal extent of β-N-AcGlc and β-galactosidase secretion on addition of metabolically stable analogues of GTP (GTPγS and GppNHp) in the absence of thrombin or of GT
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Asaji, T., E. Murakami, N. Takekoshi, S. Matsui, and T. Imaoka. "EFFECT OF ATRIAL NATRIURETIC POLYPEPTIDES ON PLATELET FUNCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644872.

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Atrial natriuretic polypeptides (ANP) have been shown to possess a potent diuretic and natriuretic activity, and medicated to patients with heart insufficiency as a drug to be mediated by cGMPaccumulation in glomeruli. A existence of receptors for ANP have recently beenreported in human platelet. But, whether ANP has a direct effect on platelet function remains to be known.Single stimulation of ANP in any concentration did not induce aggregation in neither platelet rich plasma, nor washed platelets. Also no effect of pretreatment with ANP was observed against aggregation triggered by known med
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Ueno, H., T. Yasunaga, C. Shingyoji, T. Yamaguchi, and K. Hirose. "Dynein Pulls Microtubules Without Rotating Its Stalk." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206430.

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Dynein is a motor protein that hydrolyses ATP and moves toward the minus end of a microtubule (MT). A dynein molecule has one to three heavy chains, each consisting of three domains: a head, a stalk and a tail. ATP is bound and hydrolysed in the head, which has a ring-like structure composed of 6 AAA+ domains. The stalk is an antiparallel coiled-coil, 10–15 nm long, and has a nucleotide-dependent MT-binding domain at the tip (1) (Fig. 1). It has been proposed that the nucleotide-dependent binding affinity of the tubulin-binding site at the tip of the stalk is modulated by the two alpha helices
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Liao, Jung-Chi, and George Oster. "The Engines of Biomolecular Motors." In ASME 2004 3rd Integrated Nanosystems Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/nano2004-46094.

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The majority of biomolecular motors are powered by nucleoside triphosphate (NTP), especially adenosine triphosphate (ATP). These motors consist of a β-sheet with highly conserved motifs and the nucleotide binding domain around it. The highly conserved protein folds are the engines of these motors, which convert the energy of NTP hydrolysis cycle to mechanical work. Although functions of molecular motors are widely diverse, (including cargo movement, DNA unwinding, protein degradation, ion pumping, etc), the nucleotide binding domains are very similar. In the binding site, NTP undergoes a hydro
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Budmark*, Amber, Michael Catalano*, Tyrel Haley*, Brady Hicks*, Maria Koenen*, Thea Patrick*, Tyler Larson*, et al. "Abstract 490: Single nucleotide variations within and around microRNA-binding sites." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-490.

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Jefferson, J. R., J. T. Harmon, and G. A. Jamieson. "ADP-BINDING SITES IN PLATELETS: CHARACTERIZATION BY PHOTOAFFINITY LABELING AND BINDING STUDIES WITH FIXED PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644463.

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Attempts to photoaffinity label platelet ADP receptors with 2-azidoADP have not been successful possibly due to the absence of a spacer arm between the nucleotide and the photolabile group. We have synthesized a probe having a long spacer arm by coupling 2-(3-aminopropylthio)-ADP to succinimidyl 4-3H-azidobenzoate. Labeling competable by ADP could not demonstrated with intact platelets. With isolated platelet membranes, three bands (Mr 140,000, 110,000 and 46,000) were labeled that were not competed by ADP while three other bands (Mr 188,000, 92,000 and 51,000) were competable by 100 uM ADP.An
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Perera, Alexandre, Montserrat Vallverdu, Francesc Claria, Jose Manuel Soria, and Pere Caminal. "DNA Binding Sites Characterization by Means of Rényi Entropy Measures on Nucleotide Transitions." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260482.

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Perera, Alexandre, Montserrat Vallverdu, Francesc Claria, Jose Manuel Soria, and Pere Caminal. "DNA Binding Sites Characterization by Means of Rényi Entropy Measures on Nucleotide Transitions." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4398771.

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Salekin, Sirajul, Jianqiu Michelle Zhang, and Yufei Huang. "A deep learning model for predicting transcription factor binding location at single nucleotide resolution." In 2017 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI). IEEE, 2017. http://dx.doi.org/10.1109/bhi.2017.7897204.

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