Relevant bibliographies by topics / Nucleu

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Nucleu'

Author: Grafiati
Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Nucleu"

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Vasilescu, Gabriel Dragos, Emilian Ghicioi, Sorin Simion, and Vlad Pasculescu. "Model for Forecasting the Exposure Risk of Workers to Hand-Arm Occupational Vibrations." Applied Mechanics and Materials 430 (September 2013): 276–80. http://dx.doi.org/10.4028/www.scientific.net/amm.430.276.

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This paper work presents the model for forecasting the exposure risk of workers to hand-arm occupational vibrations, which has been achieved in the PN 07 45 01 18 Project from within the framework of the NUCLEU/2012-2013 Program.This project is of national and European interest, in order to increase occupational health and safety level and to ensure sustainable environmental quality and comfort at work.
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Drumea, Petrin, Corneliu Cristescu, Catalin Dumitrescu, Iulian Dutu, and Ioana Ilie. "Research Regarding the Dynamic Behavior of Linear Hydraulic Servo-Systems." Applied Mechanics and Materials 325-326 (June 2013): 480–85. http://dx.doi.org/10.4028/www.scientific.net/amm.325-326.480.

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The paper presents the theoretical results of extensive research on the dynamic behavior of linear hydraulic motors, carried out in INOE 2000-IHP, in the framework of the NUCLEU Programmer. The research has been conducted both theoretically and experimentally, but, in this paper, is presented only the theoretical research. Theoretical research has taken place with the modern means of mathematical modeling and computer numerical simulation. The article presents some theoretical interested results obtained in the research, results that are of real scientific interest, but, also, with practical value through their use in the design of fluid power components and equipments.
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Barlas, Orhan, Ha?met A. Hana?as?, Murat ?mer, H�seyin A. ?ahin, Serra Sencer, and Murat Emre. "Do unilateral ablative lesions of the subthalamic nucleu in parkinsonian patients lead to hemiballism?" Movement Disorders 16, no. 2 (2001): 306–10. http://dx.doi.org/10.1002/mds.1051.

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Dimitrova, D. S., and D. M. Gilbert. "Regulation of mammalian replication origin usage in Xenopus egg extract." Journal of Cell Science 111, no. 19 (October 1, 1998): 2989–98. http://dx.doi.org/10.1242/jcs.111.19.2989.

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Xenopus embryos initiate replication at random closely spaced sites until a certain concentration of nuclei is achieved within the embryo, after which fewer, more specific chromosomal sites are utilized as origins. We have examined the relationship between nucleo-cytosolic ratio and origin specification when Chinese hamster ovary (CHO) cell nuclei are introduced into Xenopus egg extracts. At concentrations of intact late-G1-phase nuclei that approximate early Xenopus embryos, the entire genome was duplicated nearly 4 times faster than in culture, accompanied by a de-localization of initiation sites at the dihydrofolate reductase (DHFR) locus. As the concentration of nuclei was increased, the number of initiation sites per nucleus decreased and initiation at the DHFR locus became localized to the physiologically utilized DHFR origin. Origin specification was optimal at nuclear concentrations that approximate the Xenopus mid-blastula transition (MBT). Higher concentrations resulted in an overall inhibition of DNA synthesis. By contrast, with intact early G1-phase nuclei, replication initiated at apparently random sites at all concentrations, despite an identical relationship between nucleo-cytosolic ratio and replicon size. Furthermore, permeabilization of late-G1-phase nuclei, using newly defined conditions that preserve the overall rate of replication, eliminated site-specificity, even at nuclear concentrations optimal for DHFR origin recognition. These data show that both nucleo-cytosolic ratio and nuclear structure play important but independent roles in the regulation of replication origin usage. Nucleo-cytosolic ratio clearly influences the number of replication origins selected. However, titration of cytosolic factors is not sufficient to focus initiation to specific sites. An independent mechanism, effecting changes within G1-phase nuclei, dictates which of many potential initiation sites will function as an origin.
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Chan, Jonathan KL, Paul C. Park, and Umberto De Boni. "Association of DNAse sensitive chromatin domains with the nuclear periphery in 3T3 cells in vitro." Biochemistry and Cell Biology 78, no. 2 (April 1, 2000): 67–78. http://dx.doi.org/10.1139/o99-074.

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DNAse sensitive chromatin, putative transcriptionally competent sequences, exists either as pan-nuclear speckles in cells with nuclei which exhibit a flat geometry, or as a shell apposed to the nuclear envelope in cells with spheroidal nuclei. To test the hypothesis that DNAse sensitive chromatin is similarly associated with the nuclear periphery in cell types with a very flat geometry such as 3T3 fibroblasts, cells were subjected to hypotonic expansion to change their nuclei from a flat ellipsoid to a spheriod. This was based on the assumption that such a spatial association is not resolvable due to the interdigitation at the nuclear midplane of DNAse sensitive chromatin associated with the upper and lower nuclear surfaces. In situ nick translation was used to visualize the distribution of DNAse sensitive chromatin as a function of nuclear geometry. Both unexpanded and expanded cells exhibit DNAse sensitive chromatin as a dome at the apical side of the nucleus, i.e., that aspect of the cell facing the culture medium. The results argue for a polarized association of DNAse sensitive chromatin with the nuclear envelope and indicate that the nuclear periphery may function as a compartment for the spatial coupling of transcription and nucleo-cytoplasmic transport. Key words: nuclear organization, DNAse sensitive chromatin, hypotonic expansion, 3T3 cells.
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Leitch, Andrew R. "Higher Levels of Organization in the Interphase Nucleus of Cycling and Differentiated Cells." Microbiology and Molecular Biology Reviews 64, no. 1 (March 1, 2000): 138–52. http://dx.doi.org/10.1128/mmbr.64.1.138-152.2000.

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SUMMARY The review examines the structured organization of interphase nuclei using a range of examples from the plants, animals, and fungi. Nuclear organization is shown to be an important phenomenon in cell differentiation and development. The review commences by examining nuclei in dividing cells and shows that the organization patterns can be dynamic within the time frame of the cell cycle. When cells stop dividing, derived differentiated cells often show quite different nuclear organizations. The developmental fate of nuclei is divided into three categories. (i) The first includes nuclei that undergo one of several forms of polyploidy and can themselves change in structure during the course of development. Possible function roles of polyploidy is given. (ii) The second is nuclear reorganization without polyploidy, where nuclei reorganize their structure to form novel arrangements of proteins and chromosomes. (iii) The third is nuclear disintegration linked to programmed cell death. The role of the nucleus in this process is described. The review demonstrates that recent methods to probe nuclei for nucleic acids and proteins, as well as to examine their intranuclear distribution in vivo, has revealed much about nuclear structure. It is clear that nuclear organization can influence or be influenced by cell activity and development. However, the full functional role of many of the observed phenomena has still to be fully realized.
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Chisoi, Anca, Mariana Aşchie, and Manuela Enciu. "Morphometric Characterization of Marginal Zone Lymphoma." ARS Medica Tomitana 21, no. 1 (February 1, 2015): 17–21. http://dx.doi.org/10.1515/arsm-2015-0014.

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Abstract The morphometry in histopathology is used to characterize cell populations belonging to different tissues and to identify differences in their parameters with prognostic implications. To achieve morphometric examination were selected 6 of 8 cases identified as marginal zone lymphoma. For each case analysis was done on five fields, for each field measuring the parameters of 20 cells. The studied parameters were for cytoplasm: cytoplasmic area, maximum and minimum cytoplasmic diameter, cytoplasmic perimeter; for nucleus were measured: nuclear area, minimum and maximum nuclear diameter, nuclear perimeter, nuclear contour index, nuclear ellipticity index, nuclear irregularity index. Also the nucleo-cytoplasmic ratio was calculated in all studied cases. Marginal zone lymphoma is characterized in terms of morphometric parameters by small cytoplasmic and nuclear area, and small nucleo-cytoplasmatic ratio of about 1:1. Nuclear contour index is small, accompanied by a large ellipticity index and an small index of nuclear irregularity. Standard deviations for measured morphometric parameters are variable, having high values for cytoplasmic and nuclear area, highlighting the polymorphic nature of the cells. Morphometric aspects, with corresponding microscopic aspects of large and small lymphocyte proliferation with cleaved and uncleaved nuclei, fit this form of lymphoma in terms of clinical outcome in indolent lymphomas category.
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Foe, V. E., and B. M. Alberts. "Reversible chromosome condensation induced in Drosophila embryos by anoxia: visualization of interphase nuclear organization." Journal of Cell Biology 100, no. 5 (May 1, 1985): 1623–36. http://dx.doi.org/10.1083/jcb.100.5.1623.

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We have studied the morphology of nuclei in Drosophila embryos during the syncytial blastoderm stages. Nuclei in living embryos were viewed with differential interference-contrast optics; in addition, both isolated nuclei and fixed preparations of whole embryos were examined after staining with a DNA-specific fluorescent dye. We find that: (a) The nuclear volumes increase dramatically during interphase and then decrease during prophase of each nuclear cycle, with the magnitude of the nuclear volume increase being greatest for those cycles with the shortest interphase. (b) Oxygen deprivation of embryos produces a rapid developmental arrest that is reversible upon reaeration. During this arrest, interphase chromosomes condense against the nuclear envelope and the nuclear volumes increase dramatically. In these nuclei, individual chromosomes are clearly visible, and each condensed chromosome can be seen to adhere along its entire length to the inner surface of the swollen nuclear envelope, leaving the lumen of the nucleus devoid of DNA. (c) In each interphase nucleus the chromosomes are oriented in the "telophase configuration," with all centromeres and all telomeres at opposite poles of the nucleus; all nuclei at the embryo periphery (with the exception of the pole cell nuclei) are oriented with their centromeric poles pointing to the embryo exterior.
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Dundon, Samantha E. R., Shyr-Shea Chang, Abhishek Kumar, Patricia Occhipinti, Hari Shroff, Marcus Roper, and Amy S. Gladfelter. "Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium." Molecular Biology of the Cell 27, no. 13 (July 2016): 2000–2007. http://dx.doi.org/10.1091/mbc.e16-02-0129.

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Nuclei in syncytia found in fungi, muscles, and tumors can behave independently despite cytoplasmic translation and the homogenizing potential of diffusion. We use a dynactin mutant strain of the multinucleate fungus Ashbya gossypii with highly clustered nuclei to assess the relative contributions of nucleus and cytoplasm to nuclear autonomy. Remarkably, clustered nuclei maintain cell cycle and transcriptional autonomy; therefore some sources of nuclear independence function even with minimal cytosol insulating nuclei. In both nuclear clusters and among evenly spaced nuclei, a nucleus’ transcriptional activity dictates local cytoplasmic contents, as assessed by the localization of several cyclin mRNAs. Thus nuclear activity is a central determinant of the local cytoplasm in syncytia. Of note, we found that the number of nuclei per unit cytoplasm was identical in the mutant to that in wild-type cells, despite clustered nuclei. This work demonstrates that nuclei maintain autonomy at a submicrometer scale and simultaneously maintain a normal nucleocytoplasmic ratio across a syncytium up to the centimeter scale.
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Walters, Alison D., Kwabena Amoateng, Renjie Wang, Jian-Hua Chen, Gerry McDermott, Carolyn A. Larabell, Olivier Gadal, and Orna Cohen-Fix. "Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume." Molecular Biology of the Cell 30, no. 1 (January 2019): 131–45. http://dx.doi.org/10.1091/mbc.e18-04-0204.

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Most cells exhibit a constant ratio between nuclear and cell volume. The mechanism dictating this constant ratio and the nuclear component(s) that scale with cell size are not known. To address this, we examined the consequences to the size and shape of the budding yeast nucleus when cell expansion is inhibited by down-regulating components of the secretory pathway. We find that under conditions where cell size increase is restrained, the nucleus becomes bilobed, with the bulk of the DNA in one lobe and the nucleolus in the other. The formation of bilobed nuclei is dependent on fatty acid and phospholipid synthesis, suggesting that it is associated with nuclear membrane expansion. Bilobed nuclei appeared predominantly after spindle pole body separation, suggesting that nuclear envelope expansion follows cell-cycle cues rather than cell size. Importantly, cells with bilobed nuclei had the same nuclear:cell volume ratio as cells with round nuclei. Therefore, the bilobed nucleus could be a consequence of continued NE expansion as cells traverse the cell cycle without an accompanying increase in nuclear volume due to the inhibition of cell growth. Our data suggest that nuclear volume is not determined by nuclear envelope availability but by one or more nucleoplasmic factors.
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Dissertations / Theses on the topic "Nucleu"

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BERTORA, STEFANIA. "ROLE OF NUCLEAR ENVELOPE PROTEIN MAN1 IN NUCLEAR ORGANISATION AND MAINTENANCE OF GENOME STABILITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/554706.

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The eukaryotic cell nucleus is characterized by a defined spatial organization of the chromatin, which relies on the physical tethering of many genomic loci to the inner surface of the nuclear envelope. This interaction is mainly mediated by lamins and lamin-associated proteins, which create a protein network at the nuclear periphery called nuclear lamina. Man1 is a member of a lamin-associated protein family known as LEM-domain proteins, which are characterized by the presence of a highly conserved domain, called LEM, that mediates the interaction with the chromatin. Data obtained with the yeast Man1 homolog Src1 underline the importance of this protein in different processes of the cell cycle, such as chromosome segregation, nuclear pores assembly, gene expression, chromatin organization and maintenance of genome stability, while in animal models, the function of Man1 has been associated to the regulation of developmental signalling pathways during embryogenesis. In this study, truncated recombinant mutants of Man1, containing the LEM domain, were shown to inhibit nuclear assembly and alter nuclear pore formation when added to Xenopus laevis cell-free extracts. Moreover, Xenopus nuclei assembled in the presence of Man1 truncated fragments were characterized by defects in chromatin organization, DNA replication and accumulation of DNA damage and, as a consequence, they failed to progress through mitosis. Furthermore, mouse embryonic stem cells (mESCs) depleted for Man1 showed evident signs of spontaneous differentiation, indicating inability in the maintenance of stem cell features. Intriguingly, preliminary analysis of Man1-knockout mESCs transcriptional profile showed an alteration of gene expression at the level of pericentromeric and telomeric regions, underlining a potential link between Man1 and genomic stability of these particular regions. In conclusion, this study illustrates the importance of Man1 in ensuring the proper chromatin organization necessary to support different cellular and DNA metabolic processes.
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Masango, Senamile Khethekile Ntombizothando. "Measuring transitional matrix elements using first-order perturbation theory in Coulomb excitation." University of the Western Cape, 2019. http://hdl.handle.net/11394/6704.

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Magister Scientiae - MSc
The aim of nuclear structure physics is to study the interplay between singleparticle and collective degrees of freedom in nuclei and to explain how nuclei get excited and decay under di erent external conditions, such as strong electric and magnetic elds. If nuclei absorb a large amount of energy and angular momentum, like in a scattering reaction when you bombard a target that is in the ground state with a projectile at high bombarding energies, the energy from the projectile gets transfered to the target and vice versa, hence both projectile and target may get excited. During the de-excitation process nuclei may release the energy in a form of electromagnetic radiation (gamma rays) which carries angular momentum. The atomic nucleus is a many-body system, whose structure is de ned in terms of interactions between protons and neutrons. In nature there are only around 300 stable isotopes [1]. They are all in their ground states (although some are in a low-energy excited isomeric state with a long lifetime). To study excited states in these nuclei one needs to provide energy to the system. In addition, there are some 3000 unstable nuclei, most of which do not exist in nature. Many have been produced and studied in research laboratories, and there could be more than 3000 other unstable nuclei that can in principle exist in astrophysical environments, but have not yet been synthesized on Earth [1].
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Persram, Declan. "Delta production in nucleon-nucleon scattering and pion production in nucleus-nucleus collisions." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23931.

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We present a calculation of $ Delta$ production cross section in the one-boson-exchange model for the reaction $NN to N Delta.$ Our calculation is in quantitative agreement with a previous calculation by Huber and Aichelin (1). The effect of the $NN to N Delta$ anisotropic differential cross section on $ pi$ production in Au + Au collisions at a kinetic energy of $1{GeV over A}$ is studied. We find that there is no large effect on the final $ pi$ transverse momentum spectra.
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Alalawi, Huda. "INVESTIGATION OF NUCLEAR COMPRESSION IN THE AMPT MODELOF NUCLEUS-NUCLEUS COLLISIONS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543405727739039.

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Ngwetsheni, Cebo. "Polarizability effects due to low-energy enhancement of the gamma-strength function." University of the Western Cape, 2018. http://hdl.handle.net/11394/6705.

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>Magister Scientiae - MSc
Physics is the study of natural phenomena. Nuclear physicists have since the discovery of the nucleus been working on understanding its dynamics. The nuclear chart, analogous to the periodic table of elements, is illustrated in Fig. 1.1 and color coded according to decay modes. Several theoretical models, based on various hypothesis, have been developed during the years in order to understand nuclear phenomena such as nucleon-nucleon (n-n) interactions, binding energies, radii, excited states, etc. Unfortunately, no-unique model is actually able to grasp all nuclear phenomena at the desired level of accuracy. Among the di erent models, we notice that two distinct hypotheses can be used to describe nuclear properties. Firstly, the independent particle shell model (IPSM) + the n-n residual interaction, which assumes that a nucleon moves independently in a potential generated by other nucleons. Secondly, the macroscopic models, where a nucleus is considered as a whole, i.e. neutrons and protons behave cooperatively and are mutually coupled to each other; highlighting the short-ranged character of the nuclear force. The liquid-drop model is an example of such macroscopic models. Re nement of these models is dependent on experimental observations that are better detailed for nuclei along the line of - stability, making up a small fraction of the known isotopes, as shown in Fig. 1.1. In practice, various techniques for studying exotic nuclei up to neutron and proton drip-lines have been devised, including the use of radioactive ion beams. However, the main challenges are the synthesization and short lived periods of these exotic nuclei resulting in insu cient data collection from which the characteristics and structural information are extracted. In general, nuclei have unique structures represented by a particular con guration as given by the shell model (SM). These structures impact a number of physical quantities, e.g. transition probabilities, cross sections and photon-strength functions. Experimental methods such as Coulomb excitation or electromagnetic radiation are used to probe these structures without invoking the nuclear force.
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Alhomaidhi, Sultan Mohammad A. "Search for Maximum Nuclear Compression in a Model of Nucleus-Nucleus Collisions." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1448216380.

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Schmookler, Barak (Barak A. ). "Nucleon structure and Its modification in nuclei." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119928.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 181-184).
Inclusive electron scattering experiments using fixed targets are an important tool for studying the structure of the nucleons. The electromagnetic structure of the proton, as encapsulated by its elastic form factors, can be extracted through measurements of the elastic electron-proton scattering cross-section. The GMp experiment in Hall A at the Thomas Jefferson National Accelerator Facility (JLab) seeks to measure this cross-section with high precision up to large momentum transfers. In addition, it is known that the inelastic structure of the nucleon is modified inside the nucleus. This modification, known as the EMC effect, can be studied using inclusive electron Deep Inelastic Scattering (DIS) on a nuclear target. Evidence suggests that the EMC effect may arise due to nucleon Short Range Correlations (SRC). This thesis describes studies of the elastic proton form factor measured in the GMp experiment at Hall A of JLab and studies of the EMC effect in nuclei relative to deuterium using data collected at the CLAS detector in Hall B at JLab. Furthermore, this works presents new measurements of SRC pair abundances in nuclei and develops a data-driven SRCbased phenomenological model of the EMC effect, which can correctly describe the effect across nuclei.
by Barak Schmookler.
Ph. D.
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Shim, Sugie. "Relativistic analyses of inelastic nucleon-nucleus scattering /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672631598132.

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Lavitas, Liron-Mark. "Nuclear architecture and genome function in mammalian nuclei." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/39396.

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Large-scale chromatin folding is a key mechanism in gene regulation leading to variable and dynamic gene activation in each cell. Multiple mechanisms contribute to gene regulation including the binding of regulatory factors to specific genomic sequences, chromatin interactions and repositioning of genomic regions relative to specific nuclear landmarks. The aim of this thesis was to explore genome architecture at single allele-resolution either in a gene-specific context in relation to its expression pattern or in a genome-wide context. Upon viral infection, Interferon ? (IFN?), a critical player in innate immunity, is expressed stochastically only in a fraction of cells. I used Sendai virus infected mouse embryonic fibroblasts (MEFs) as a model system to study the influence of nuclear positioning on the stochastic activity of the IFN? gene. A mouse fibroblast cell line (L929) overexpressing the IFN? transcription factor IRF7 was used as a model of constitutive expression, for comparison. IFN? was found to associate with the nuclear lamina in MEFs and L929 cells prior to infection and dissociate upon infection. Induced repositioning of the IFN? gene away from the lamina by TSA treatment, in MEFs, or by IRF7 overexpression, in L929 cells, lead to higher IFN? expression with retention of stochasticity in MEFs, but complete attenuation of stochasticity in L929 cells. Thus, the IFN? association with the lamina correlates with its on/off state and stochastic behaviour. Identification of long-range chromatin interactions by 3C approaches plays major roles in advancing our understanding of gene regulation. However, current methodologies have several limitations. I contributed to the development of a novel genome-wide mapping technology to measure chromatin contacts. In contrast with 3C technologies, this approach is compatible with mapping high multiplicity interactions at single allele and cell resolution, in complex tissues. The dynamic nature of gene regulation lies in diverse features of large-scale chromatin folding. The IFN? study highlights a role of lamina association in the mechanism of gene-specific stochastic transcriptional activation. The novel mapping technology will provide a genome-wide qualitative tool to study the dynamics of chromatin contacts in single cells.
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White, Gareth Nicholas. "Nuclear orientation of odd-A nuclei near to '1'3'2SN." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300726.

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Books on the topic "Nucleu"

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Wilson, John W. Nucleon-nucleus interaction data base: Total nuclear and absorption cross sections. Hampton, Va: Langley Research Center, 1988.

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1940-, Wilson John W., and United States. National Aeronautics and Space Administration. Scientific and Technical Information Division., eds. Nucleon-nucleus interaction data base: Total nuclear and absorption cross section. [Washington, D.C.]: National Aeronautics and Space Administration, Scientific and Technical Information Division, 1988.

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1940-, Wilson John W., and United States. National Aeronautics and Space Administration. Scientific and Technical Information Division., eds. Nucleon-nucleus interaction data base: Total nuclear and absorption cross section. [Washington, D.C.]: National Aeronautics and Space Administration, Scientific and Technical Information Division, 1988.

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1940-, Wilson John W., and United States. National Aeronautics and Space Administration. Scientific and Technical Information Division., eds. Nucleon-nucleus interaction data base: Total nuclear and absorption cross section. [Washington, D.C.]: National Aeronautics and Space Administration, Scientific and Technical Information Division, 1988.

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Antonov, Anton Nikolaev, Peter Edward Hodgson, and Ivan Zhelyazkov Petkov. Nucleon Correlations in Nuclei. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77766-0.

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Antonov, Anton Nikolaev. Nucleon Correlations in Nuclei. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993.

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E, Hodgson P., and Petkov I. Zh, eds. Nucleon correlations in nuclei. Berlin: Springer-Verlag, 1993.

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International Conference on Antinucleon- and Nucleon-Nucleus Interactions (1985 Telluride, Colo.). Antinucleon- and nucleon-nucleus interactions. New York: Plenum Press, 1985.

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Sitenko, A. G. Theory of nucleus: Nuclear structure and nuclear interaction. Dordrecht: Kluwer Academic, 1997.

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Sitenko, A. G. Theory of Nucleus: Nuclear Structure and Nuclear Interaction. Dordrecht: Springer Netherlands, 1997.

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Book chapters on the topic "Nucleu"

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Svoren, Martin, Elena Camerini, Merijn van Erp, Feng Wei Yang, Gert-Jan Bakker, and Katarina Wolf. "Approaches to Determine Nuclear Shape in Cells During Migration Through Collagen Matrices." In Cell Migration in Three Dimensions, 97–114. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2887-4_7.

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AbstractFibrillar collagen is an abundant extracellular matrix (ECM) component of interstitial tissues which supports the structure of many organs, including the skin and breast. Many different physiological processes, but also pathological processes such as metastatic cancer invasion, involve interstitial cell migration. Often, cell movement takes place through small ECM gaps and pores and depends upon the ability of the cell and its stiff nucleus to deform. Such nuclear deformation during cell migration may impact nuclear integrity, such as of chromatin or the nuclear envelope, and therefore the morphometric analysis of nuclear shapes can provide valuable insight into a broad variety of biological processes. Here, we describe a protocol on how to generate a cell-collagen model in vitro and how to use confocal microscopy for the static and dynamic visualization of labeled nuclei in single migratory cells. We developed, and here provide, two scripts that (Fidler, Nat Rev Cancer 3(6):453–458, 2003) enable the semi-automated and fast quantification of static single nuclear shape descriptors, such as aspect ratio or circularity, and the nuclear irregularity index that forms a combination of four distinct shape descriptors, as well as (Frantz et al., J Cell Sci 123 (Pt 24):4195–4200, 2010) a quantification of their changes over time. Finally, we provide quantitative measurements on nuclear shapes from cells that migrated through collagen either in the presence or the absence of an inhibitor of collagen degradation, showing the distinctive power of this approach. This pipeline can also be applied to cell migration studied in different assays, ranging from 3D microfluidics to migration in the living organism.
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Glashausser, Charles. "Nucleon-nucleus inelastic scattering." In Medium Energy Nucleon and Antinucleon Scattering, 230–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/3-540-16054-x_170.

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Bondorf, J. P., and K. Sneppen. "Nuclear Matter and Fragmenting Nuclei." In NATO ASI Series, 267–85. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5715-5_10.

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Karataglidis, Steven, Ken Amos, Paul R. Fraser, and Luciano Canton. "MCAS and Nucleon-Nucleus Clusters." In A New Development at the Intersection of Nuclear Structure and Reaction Theory, 125–99. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21070-0_7.

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Jones, Edward G. "The Anterior Nuclei and Lateral Dorsal Nucleus." In The Thalamus, 673–97. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4615-1749-8_14.

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Blanchard, John W., Alexander O. Sushkov, and Arne Wickenbrock. "Magnetic Resonance Searches." In The Search for Ultralight Bosonic Dark Matter, 173–200. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95852-7_6.

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AbstractUltralight bosonic dark matter (UBDM), such as axions and axionlike particles (ALPs), can interact with Standard Model particles via a variety of portals. One type of portal induces electric dipole moments (EDMs) of nuclei and electrons and another type generates torques on nuclear and electronic spins. Several experiments search for interactions of spins with the galactic dark matter background via these portals, comprising a new class of dark matter haloscopes based on magnetic resonance.
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Mackintosh, R. S., and S. G. Cooper. "Nucleon-Nucleus Potentials by IP Inversion." In Lecture Notes in Physics, 266–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-13969-1_17.

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Langanke, Karlheinz, Friedrich-Karl Thielemann, and Michael Wiescher. "Nuclear Astrophysicsand Nuclei Far from Stability." In The Euroschool Lectures on Physics with Exotic Beams, Vol. I, 383–467. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-44490-9_11.

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Ho, Paul T. P. "Nuclear ISM: Feeding the Galactic Nucleus." In The Nuclei of Normal Galaxies, 149–60. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0752-5_20.

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Smith, Richard D. "Nucleon-Nucleus Scattering to the Continuum." In Spin Observables of Nuclear Probes, 15–51. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0769-3_2.

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Conference papers on the topic "Nucleu"

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SAMMARRUCA, FRANCESCA. "PROBING MEDIUM EFFECTS ON THE NUCLEON-NUCLEON INTERACTION IN NUCLEAR MATTER AND NUCLEI." In Proceedings of the Kyudai-RCNP International Symposium. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812704870_0032.

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Hauser, H. J., T. Rohwer, F. Hoyler, G. Staudt, S. Abd, P. Grasshoff, H. V. Klapdor, et al. "Nuclear spectroscopy with few-nucleon transfer reactions on light nuclei." In AIP Conference Proceedings Volume 125. AIP, 1985. http://dx.doi.org/10.1063/1.35068.

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MA, ZHONG-YU, JIAN RONG, and YIN-QUN MA. "MICROSCOPIC OPTICAL POTENTIALS OF NUCLEON-NUCLEUS AND NUCLEUS-NUCLEUS SCATTERING." In Proceedings of the International Symposium EXOCT07. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812797049_0013.

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Noro, T., O. V. Miklukho, E. Obayashi, V. A. Andreev, M. N. Andronenko, G. M. Amalsky, S. L. Belostotski, et al. "Study of nuclear medium effect on hadrons in nuclei by nucleon quasifree scattering." In NUCLEAR PHYSICS IN THE 21st CENTURY:International Nuclear Physics Conference INPC 2001. AIP, 2002. http://dx.doi.org/10.1063/1.1470278.

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Ejiri, H., T. Noro, K. Takahisa, and H. Toki. "Nuclear Reaction Dynamics of Nucleon—Hadron Many Body System; From Nuclear Spins & Mesons in Nuclei to Quark Lepton Nuclear Physics." In 14th RCNP OSAKA International Symposium. WORLD SCIENTIFIC, 1996. http://dx.doi.org/10.1142/9789814530958.

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Fogaça, D. A. "Solitons in nucleon-nucleus collisions." In IX HADRON PHYSICS AND VII RELATIVISTIC ASPECTS OF NUCLEAR PHYSICS: A Joint Meeting on QCD and QCP. AIP, 2004. http://dx.doi.org/10.1063/1.1843697.

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SUZUKI, TOSHIO. "SPIN MODES IN NUCLEI AND NEUTRINO NUCLEUS REACTIONS." In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701749_0066.

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Hirai, M., S. Kumano, K. Saito, Federico Sanchez, M. Sorel, and Luis Alvarez-Ruso. "Nuclear effects in neutrino-nucleus DIS." In SIXTH INTERNATIONAL WORKSHOP ON NEUTRINO-NUCEUS INTERACTIONS IN THE FEW-GEV REGION (NUINT-09). AIP, 2009. http://dx.doi.org/10.1063/1.3274169.

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Ferreira, L. S., E. Maglione, P. Arumugam, Dugersuren Dashdorj, and Gary E. Mitchell. "Nuclear Structure Studies of Exotic Nuclei." In SECOND INTERNATIONAL ULAANBAATAR CONFERENCE ON NUCLEAR PHYSICS AND APPLICATIONS. AIP, 2011. http://dx.doi.org/10.1063/1.3583161.

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Litvinov, Yuri A., and Klaus Blaum. "Weighing exotic nuclei for nuclear astrophysics." In ORIGIN OF MATTER AND EVOLUTION OF GALAXIES 2011. AIP, 2012. http://dx.doi.org/10.1063/1.4763375.

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Reports on the topic "Nucleu"

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Riley, Mark, and Akis Pipidis. The Mechanical Analogue of the "Backbending" Phenomenon in Nuclear-structure Physics. Florida State University, May 2008. http://dx.doi.org/10.33009/fsu_physics-backbending.

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This short pedagogical movie illustrates an effect in nuclear physics called backbending which was first observed in the study of the rotational behavior of rapidly rotating rare-earth nuclei in Stockholm, Sweden in 1971. The video contains a mechanical analog utilizing rare-earth magnets and rotating gyroscopes on a turntable along with some historic spectra and papers associated with this landmark discovery together with its explanation in terms of the Coriolis induced uncoupling and rotational alignment of a specific pair of particles occupying high-j intruder orbitals. Thus backbending represents a crossing in energy of the groundstate, or vacuum, rotational band by another band which has two unpaired high-j nucleons (two quasi-particles) with their individual angular momenta aligned with the rotation axis of the rapidly rotating nucleus. Backbending was a major surprise which pushed the field of nuclear structure physics forward but which is now sufficiently well understood that it can be used as a precision spectroscopic tool providing useful insight for example, into nuclear pairing correlations and changes in the latter due to blocking effects and quasi-particle seniority, nuclear deformation, the excited configurations of particular rotational structures and the placement of proton and neutron intruder orbitals at the Fermi surface.
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Citovsky, Vitaly, and Yedidya Gafni. Viral and Host Cell Determinants of Nuclear Import and Export of the Tomato Yellow Leaf Curl Virus in Tomato Plants. United States Department of Agriculture, August 2002. http://dx.doi.org/10.32747/2002.7585200.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel, where TYLCV epidemics have been recorded since the 1960' s, this viral disease is well known and has been of economic significance ever since. In recent years, TYLCV outbreaks also occurred in the "New World" - Cuba, The Dominican Republic, and in the USA, in Florida, Georgia and Louisiana. Thus, TYLCV substantially hinders tomato growth throughout the world. Surprisingly, however, little is known about the molecular mechanisms of TYLCV interaction with the host tomato cells. The present proposal, a continuation of the project supported by BARD from 1994, expanded our understanding of the molecular mechanisms by which TYLCV enters the host cell nucleus for replication and transcription and exits it for the subsequent cell-to-cell spread. Our project sought two objectives: I. To study the roles of the viral capsid protein (CP) and host cell factors in TYLCV nuclear import. II. To study the roles of CP and host cell factors in TYLCV nuclear export. Our research toward these goals have produced the following major achievements: . Developed a one-hybrid assay for protein nuclear export and import (#3 in the List of Publications). . Identified a functional nuclear export signal (NES) in the capsid protein (CP) of TYLCV (#3 in the List of Publications). . Discovered homotypic interactions between intact TYLCV CP molecules and analyzed these interactions using deletion mutagenesis of TYLCV CP (#5 in the List of Publications). . Showed developmental and tissue-specific expression of the host factor required for nuclear import of TYLCV CP, tomato karyopherin alpha 1, in transgenic tomato plants (#14 in the List of Publications). . By analogy to nuclear import of TYLCV ,identified an Arabidopsis VIPI protein that participates in nuclear import of Agrobacterium T -complexes via the karyopherin alpha pathway (#4,6, and 8 in the List of Publications). These research findings provided significant insights into (i) the molecular pathway of TYLCV entry into the host cell nucleus, and (ii) the mechanism by which TYLCV is exported from the nucleus for the cell-to-cell spread of infection. Furthermore, the obtained knowledge will help to develop specific strategies to attenuate TYLCV infection, for example, by blocking viral entry into and/or exit out of the host cell nucleus. Also, as much of our findings is relevant to all geminiviruses, new anti- TYLCV approaches developed based on the results of our research will be useful to combat other members of the Geminivirus family. Finally, in addition to the study of TYLCV nuclear import and export, our research contributed to our understanding of general mechanisms for nucleocytoplasmic shuttling of proteins and nucleic acids in plant cells.
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Citovsky, Vitaly, and Yedidya Gafni. Nuclear Import of the Tomato Yellow Curl Leaf Virus in Tomato Plants. United States Department of Agriculture, September 1994. http://dx.doi.org/10.32747/1994.7568765.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel the disease is well known and has an economic significance. In recent years viral symptoms were found in countries of the "New World" and since 1997, in Florida. Surprisingly, little is known about the molecular mechanisms of TYLCV interaction with the host plant cells. This proposal was aimed at expanding our understanding of the molecular mechanisms by which TYLCV enters the host cell nucleus. The main objective was to elucidate the TYLCV protein(s) involved in transport of the viral genomic DNA into the host cell nucleus. This goal was best served by collaboration between our laboratories one of which (V.C.) was already investigating the nuclear import of the T-DNA ofAgrobacterium tumefaciens, and the other (Y.G.) was studying the effect of TYLCV capsid protein (CP) in transgenic plants, hypothesizing its involvement in the viral nuclear entry. Three years of our collaborative work have provided signifcant data that strongly support our original hypothesis of the involvement of TYLCtr CP in viral nuclear import. Furthermore, our results have laid a foundation to study fundamental, but as yet practically unresolved, questions about the role ofthe host cell factors in the nuclear import of geminiviruses within their host plant. As a result, this research may lead to development of new approaches for plant protection based on control of TYLCV import to the host plant cell nucleus.
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Midak, Liliia Ya, Ivan V. Kravets, Olga V. Kuzyshyn, Tetiana V. Kostiuk, Khrystyna V. Buzhdyhan, Victor M. Lutsyshyn, Ivanna O. Hladkoskok, Arnold E. Kiv, and Mariya P. Shyshkina. Augmented reality while studying radiochemistry for the upcoming chemistry teachers. [б. в.], July 2021. http://dx.doi.org/10.31812/123456789/4627.

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The objective of the research is developing a mobile application (on Android) designed to visualize the basic definitions of the discipline “Radiochemistry and radioecology” in 3D. Studying the education material of this discipline (phenomena of radionuclide, radioisotope, the nucleus, the fundamental particle etc and their specifics) requires a more sophisticated explanation from the teacher and dynamic dimensional image from the student. Decent detailed visualization of the study material makes this process easier. So applying the augmented reality is rational for the purpose of visualizing the study material, applying it allows demonstrate 3D-models of the nucleus, the fundamental particles, the nature of radioactive decay, nuclear fission, the specifics of managing the nuclear weapon and the NPS. Involving this instrument of the up-to-date information and communication technologies while studying the new material gives the opportunity to develop and boost the spatial imagination of the students, “to see” the invisible and to understand the received material in a better way, which improves its better memorizing. As far as the augmented reality is one of the most recent new-age education trends, all the teachers are required to have the ability to use it. In this reason the upcoming teachers, the students of the “General Education (Chemistry)” specialty, must be trained with this technology. Within the study process the students have the opportunity to review the positive moments of applying AR from a student’s stand of point and to understand, how to apply similar education tools in the future pedagogic work.
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Gafni, Yedidya, and Vitaly Citovsky. Molecular interactions of TYLCV capsid protein during assembly of viral particles. United States Department of Agriculture, April 2007. http://dx.doi.org/10.32747/2007.7587233.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. The present proposal, a continuation of a BARD-funded project, expanded our understanding of the molecular mechanisms by which CP molecules, as well as its pre-coat partner V2, interact with each other (CP), with the viral genome, and with cellular proteins during assembly and movement of the infectious virions. Specifically, two major objectives were proposed: I. To study in detail the molecular interactions between CP molecules and between CP and ssDNA leading to assembly of infectious TYLCV virions. II. To study the roles of host cell factors in TYLCV assembly. Our research toward these goals has produced the following major achievements: • Characterization of the CP nuclear shuttling interactor, karyopherin alpha 1, its pattern of expression and the putative involvement of auxin in regulation of its expression. (#1 in our list of publication, Mizrachy, Dabush et al. 2004). • Identify a single amino acid in the capsid protein’s sequence that is critical for normal virus life-cycle. (#2 in our list of publications, Yaakov, Levy et al. in preparation). • Development of monoclonal antibodies with high specificity to the capsid protein of TYLCV. (#3 in our list of publications, Solmensky, Zrachya et al. in press). • Generation of Tomato plants resistant to TYLCV by expressing transgene coding for siRNA targeted at the TYLCV CP. (#4 in our list of publications, Zrachya, Kumar et al. in press). •These research findings provided significant insights into (i) the molecular interactions of TYLCV capsid protein with the host cell nuclear shuttling receptor, and (ii) the mechanism by which TYLCV V2 is involved in the silencing of PTGS and contributes to the virus pathogenicity effect. Furthermore, the obtained knowledge helped us to develop specific strategies to attenuate TYLCV infection, for example, by blocking viral entry into and/or exit out of the host cell nucleus via siRNA as we showed in our publication recently (# 4 in our list of publications). Finally, in addition to the study of TYLCV nuclear import and export, our research contributed to our understanding of general mechanisms for nucleocytoplasmic shuttling of proteins and nucleic acids in plant cells. Also integration for stable transformation of ssDNA mediated by our model pathogen Agrobacterium tumefaciens led to identification of plant specific proteins involved.
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Keane, D. Nucleus-nucleus collisions and the nuclear equation of state. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6694884.

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Tzfira, Tzvi, Michael Elbaum, and Sharon Wolf. DNA transfer by Agrobacterium: a cooperative interaction of ssDNA, virulence proteins, and plant host factors. United States Department of Agriculture, December 2005. http://dx.doi.org/10.32747/2005.7695881.bard.

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Agrobacteriumtumefaciensmediates genetic transformation of plants. The possibility of exchanging the natural genes for other DNA has led to Agrobacterium’s emergence as the primary vector for genetic modification of plants. The similarity among eukaryotic mechanisms of nuclear import also suggests use of its active elements as media for non-viral genetic therapy in animals. These considerations motivate the present study of the process that carries DNA of bacterial origin into the host nucleus. The infective pathway of Agrobacterium involves excision of a single-stranded DNA molecule (T-strand) from the bacterial tumor-inducing plasmid. This transferred DNA (T-DNA) travels to the host cell cytoplasm along with two virulence proteins, VirD2 and VirE2, through a specific bacteriumplant channel(s). Little is known about the precise structure and composition of the resulting complex within the host cell and even less is known about the mechanism of its nuclear import and integration into the host cell genome. In the present proposal we combined the expertise of the US and Israeli labs and revealed many of the biophysical and biological properties of the genetic transformation process, thus enhancing our understanding of the processes leading to nuclear import and integration of the Agrobacterium T-DNA. Specifically, we sought to: I. Elucidate the interaction of the T-strand with its chaperones. II. Analyzing the three-dimensional structure of the T-complex and its chaperones in vitro. III. Analyze kinetics of T-complex formation and T-complex nuclear import. During the past three years we accomplished our goals and made the following major discoveries: (1) Resolved the VirE2-ssDNA three-dimensional structure. (2) Characterized VirE2-ssDNA assembly and aggregation, along with regulation by VirE1. (3) Studied VirE2-ssDNA nuclear import by electron tomography. (4) Showed that T-DNA integrates via double-stranded (ds) intermediates. (5) Identified that Arabidopsis Ku80 interacts with dsT-DNA intermediates and is essential for T-DNA integration. (6) Found a role of targeted proteolysis in T-DNA uncoating. Our research provide significant physical, molecular, and structural insights into the Tcomplex structure and composition, the effect of host receptors on its nuclear import, the mechanism of T-DNA nuclear import, proteolysis and integration in host cells. Understanding the mechanical and molecular basis for T-DNA nuclear import and integration is an essential key for the development of new strategies for genetic transformation of recalcitrant plant species. Thus, the knowledge gained in this study can potentially be applied to enhance the transformation process by interfering with key steps of the transformation process (i.e. nuclear import, proteolysis and integration). Finally, in addition to the study of Agrobacterium-host interaction, our research also revealed some fundamental insights into basic cellular mechanisms of nuclear import, targeted proteolysis, protein-DNA interactions and DNA repair.
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Ostersetzer-Biran, Oren, and Alice Barkan. Nuclear Encoded RNA Splicing Factors in Plant Mitochondria. United States Department of Agriculture, February 2009. http://dx.doi.org/10.32747/2009.7592111.bard.

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Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development. These activities are dependent upon the tight regulation of the expression and accumulation of various organellar proteins. Plant mitochondria contain their own genomes (mtDNA), which encode for a small number of genes required in organellar genome expression and respiration. Yet, the vast majority of the organellar proteins are encoded by nuclear genes, thus necessitating complex mechanisms to coordinate the expression and accumulation of proteins encoded by the two remote genomes. Many organellar genes are interrupted by intervening sequences (introns), which are removed from the primary presequences via splicing. According to conserved features of their sequences these introns are all classified as “group-II”. Their splicing is necessary for organellar activity and is dependent upon nuclear-encoded RNA-binding cofactors. However, to-date, only a tiny fraction of the proteins expected to be involved in these activities have been identified. Accordingly, this project aimed to identify nuclear-encoded proteins required for mitochondrial RNA splicing in plants, and to analyze their specific roles in the splicing of group-II intron RNAs. In non-plant systems, group-II intron splicing is mediated by proteins encoded within the introns themselves, known as maturases, which act specifically in the splicing of the introns in which they are encoded. Only one mitochondrial intron in plants has retained its maturaseORF (matR), but its roles in organellar intron splicing are unknown. Clues to other proteins required for organellar intron splicing are scarce, but these are likely encoded in the nucleus as there are no other obvious candidates among the remaining ORFs within the mtDNA. Through genetic screens in maize, the Barkan lab identified numerous nuclear genes that are required for the splicing of many of the introns within the plastid genome. Several of these genes are related to one another (i.e. crs1, caf1, caf2, and cfm2) in that they share a previously uncharacterized domain of archaeal origin, the CRM domain. The Arabidopsis genome contains 16 CRM-related genes, which contain between one and four repeats of the domain. Several of these are predicted to the mitochondria and are thus postulated to act in the splicing of group-II introns in the organelle(s) to which they are localized. In addition, plant genomes also harbor several genes that are closely related to group-II intron-encoded maturases (nMats), which exist in the nucleus as 'self-standing' ORFs, out of the context of their cognate "host" group-II introns and are predicted to reside within the mitochondria. The similarity with known group-II intron splicing factors identified in other systems and their predicted localization to mitochondria in plants suggest that nuclear-encoded CRM and nMat related proteins may function in the splicing of mitochondrial-encoded introns. In this proposal we proposed to (i) establish the intracellular locations of several CRM and nMat proteins; (ii) to test whether mutations in their genes impairs the splicing of mitochondrial introns; and to (iii) determine whether these proteins are bound to the mitochondrial introns in vivo.
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Horoi, Mihai. Nuclear Computational Low Energy Initiative (NUCLEI). Office of Scientific and Technical Information (OSTI), October 2018. http://dx.doi.org/10.2172/1495697.

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Reddy, Sanjay K. Nuclear Computational Low Energy Initiative (NUCLEI). Office of Scientific and Technical Information (OSTI), August 2017. http://dx.doi.org/10.2172/1416183.

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