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BERTORA, STEFANIA. "ROLE OF NUCLEAR ENVELOPE PROTEIN MAN1 IN NUCLEAR ORGANISATION AND MAINTENANCE OF GENOME STABILITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/554706.
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The eukaryotic cell nucleus is characterized by a defined spatial organization of the chromatin, which relies on the physical tethering of many genomic loci to the inner surface of the nuclear envelope. This interaction is mainly mediated by lamins and lamin-associated proteins, which create a protein network at the nuclear periphery called nuclear lamina. Man1 is a member of a lamin-associated protein family known as LEM-domain proteins, which are characterized by the presence of a highly conserved domain, called LEM, that mediates the interaction with the chromatin. Data obtained with the yeast Man1 homolog Src1 underline the importance of this protein in different processes of the cell cycle, such as chromosome segregation, nuclear pores assembly, gene expression, chromatin organization and maintenance of genome stability, while in animal models, the function of Man1 has been associated to the regulation of developmental signalling pathways during embryogenesis. In this study, truncated recombinant mutants of Man1, containing the LEM domain, were shown to inhibit nuclear assembly and alter nuclear pore formation when added to Xenopus laevis cell-free extracts. Moreover, Xenopus nuclei assembled in the presence of Man1 truncated fragments were characterized by defects in chromatin organization, DNA replication and accumulation of DNA damage and, as a consequence, they failed to progress through mitosis. Furthermore, mouse embryonic stem cells (mESCs) depleted for Man1 showed evident signs of spontaneous differentiation, indicating inability in the maintenance of stem cell features. Intriguingly, preliminary analysis of Man1-knockout mESCs transcriptional profile showed an alteration of gene expression at the level of pericentromeric and telomeric regions, underlining a potential link between Man1 and genomic stability of these particular regions. In conclusion, this study illustrates the importance of Man1 in ensuring the proper chromatin organization necessary to support different cellular and DNA metabolic processes.
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Masango, Senamile Khethekile Ntombizothando. "Measuring transitional matrix elements using first-order perturbation theory in Coulomb excitation." University of the Western Cape, 2019. http://hdl.handle.net/11394/6704.
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Magister Scientiae - MScThe aim of nuclear structure physics is to study the interplay between singleparticle and collective degrees of freedom in nuclei and to explain how nuclei get excited and decay under di erent external conditions, such as strong electric and magnetic elds. If nuclei absorb a large amount of energy and angular momentum, like in a scattering reaction when you bombard a target that is in the ground state with a projectile at high bombarding energies, the energy from the projectile gets transfered to the target and vice versa, hence both projectile and target may get excited. During the de-excitation process nuclei may release the energy in a form of electromagnetic radiation (gamma rays) which carries angular momentum. The atomic nucleus is a many-body system, whose structure is de ned in terms of interactions between protons and neutrons. In nature there are only around 300 stable isotopes [1]. They are all in their ground states (although some are in a low-energy excited isomeric state with a long lifetime). To study excited states in these nuclei one needs to provide energy to the system. In addition, there are some 3000 unstable nuclei, most of which do not exist in nature. Many have been produced and studied in research laboratories, and there could be more than 3000 other unstable nuclei that can in principle exist in astrophysical environments, but have not yet been synthesized on Earth [1].
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Persram, Declan. "Delta production in nucleon-nucleon scattering and pion production in nucleus-nucleus collisions." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23931.
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We present a calculation of $ Delta$ production cross section in the one-boson-exchange model for the reaction $NN to N Delta.$ Our calculation is in quantitative agreement with a previous calculation by Huber and Aichelin (1). The effect of the $NN to N Delta$ anisotropic differential cross section on $ pi$ production in Au + Au collisions at a kinetic energy of $1{GeV over A}$ is studied. We find that there is no large effect on the final $ pi$ transverse momentum spectra.
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Alalawi, Huda. "INVESTIGATION OF NUCLEAR COMPRESSION IN THE AMPT MODELOF NUCLEUS-NUCLEUS COLLISIONS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543405727739039.
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Ngwetsheni, Cebo. "Polarizability effects due to low-energy enhancement of the gamma-strength function." University of the Western Cape, 2018. http://hdl.handle.net/11394/6705.
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>Magister Scientiae - MScPhysics is the study of natural phenomena. Nuclear physicists have since the discovery of the nucleus been working on understanding its dynamics. The nuclear chart, analogous to the periodic table of elements, is illustrated in Fig. 1.1 and color coded according to decay modes. Several theoretical models, based on various hypothesis, have been developed during the years in order to understand nuclear phenomena such as nucleon-nucleon (n-n) interactions, binding energies, radii, excited states, etc. Unfortunately, no-unique model is actually able to grasp all nuclear phenomena at the desired level of accuracy. Among the di erent models, we notice that two distinct hypotheses can be used to describe nuclear properties. Firstly, the independent particle shell model (IPSM) + the n-n residual interaction, which assumes that a nucleon moves independently in a potential generated by other nucleons. Secondly, the macroscopic models, where a nucleus is considered as a whole, i.e. neutrons and protons behave cooperatively and are mutually coupled to each other; highlighting the short-ranged character of the nuclear force. The liquid-drop model is an example of such macroscopic models. Re nement of these models is dependent on experimental observations that are better detailed for nuclei along the line of - stability, making up a small fraction of the known isotopes, as shown in Fig. 1.1. In practice, various techniques for studying exotic nuclei up to neutron and proton drip-lines have been devised, including the use of radioactive ion beams. However, the main challenges are the synthesization and short lived periods of these exotic nuclei resulting in insu cient data collection from which the characteristics and structural information are extracted. In general, nuclei have unique structures represented by a particular con guration as given by the shell model (SM). These structures impact a number of physical quantities, e.g. transition probabilities, cross sections and photon-strength functions. Experimental methods such as Coulomb excitation or electromagnetic radiation are used to probe these structures without invoking the nuclear force.
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Alhomaidhi, Sultan Mohammad A. "Search for Maximum Nuclear Compression in a Model of Nucleus-Nucleus Collisions." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1448216380.
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Schmookler, Barak (Barak A. ). "Nucleon structure and Its modification in nuclei." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119928.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2018.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 181-184).
Inclusive electron scattering experiments using fixed targets are an important tool for studying the structure of the nucleons. The electromagnetic structure of the proton, as encapsulated by its elastic form factors, can be extracted through measurements of the elastic electron-proton scattering cross-section. The GMp experiment in Hall A at the Thomas Jefferson National Accelerator Facility (JLab) seeks to measure this cross-section with high precision up to large momentum transfers. In addition, it is known that the inelastic structure of the nucleon is modified inside the nucleus. This modification, known as the EMC effect, can be studied using inclusive electron Deep Inelastic Scattering (DIS) on a nuclear target. Evidence suggests that the EMC effect may arise due to nucleon Short Range Correlations (SRC). This thesis describes studies of the elastic proton form factor measured in the GMp experiment at Hall A of JLab and studies of the EMC effect in nuclei relative to deuterium using data collected at the CLAS detector in Hall B at JLab. Furthermore, this works presents new measurements of SRC pair abundances in nuclei and develops a data-driven SRCbased phenomenological model of the EMC effect, which can correctly describe the effect across nuclei.
by Barak Schmookler.
Ph. D.
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Shim, Sugie. "Relativistic analyses of inelastic nucleon-nucleus scattering /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672631598132.
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Lavitas, Liron-Mark. "Nuclear architecture and genome function in mammalian nuclei." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/39396.
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Large-scale chromatin folding is a key mechanism in gene regulation leading to variable and dynamic gene activation in each cell. Multiple mechanisms contribute to gene regulation including the binding of regulatory factors to specific genomic sequences, chromatin interactions and repositioning of genomic regions relative to specific nuclear landmarks. The aim of this thesis was to explore genome architecture at single allele-resolution either in a gene-specific context in relation to its expression pattern or in a genome-wide context. Upon viral infection, Interferon ? (IFN?), a critical player in innate immunity, is expressed stochastically only in a fraction of cells. I used Sendai virus infected mouse embryonic fibroblasts (MEFs) as a model system to study the influence of nuclear positioning on the stochastic activity of the IFN? gene. A mouse fibroblast cell line (L929) overexpressing the IFN? transcription factor IRF7 was used as a model of constitutive expression, for comparison. IFN? was found to associate with the nuclear lamina in MEFs and L929 cells prior to infection and dissociate upon infection. Induced repositioning of the IFN? gene away from the lamina by TSA treatment, in MEFs, or by IRF7 overexpression, in L929 cells, lead to higher IFN? expression with retention of stochasticity in MEFs, but complete attenuation of stochasticity in L929 cells. Thus, the IFN? association with the lamina correlates with its on/off state and stochastic behaviour. Identification of long-range chromatin interactions by 3C approaches plays major roles in advancing our understanding of gene regulation. However, current methodologies have several limitations. I contributed to the development of a novel genome-wide mapping technology to measure chromatin contacts. In contrast with 3C technologies, this approach is compatible with mapping high multiplicity interactions at single allele and cell resolution, in complex tissues. The dynamic nature of gene regulation lies in diverse features of large-scale chromatin folding. The IFN? study highlights a role of lamina association in the mechanism of gene-specific stochastic transcriptional activation. The novel mapping technology will provide a genome-wide qualitative tool to study the dynamics of chromatin contacts in single cells.
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White, Gareth Nicholas. "Nuclear orientation of odd-A nuclei near to '1'3'2SN." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300726.
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Cicerchia, M. "The decay of the 46Ti*: a comparative study of four entrance channels." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425896.
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The purpose of this thesis is to report on the analysis done on the four reactions: 16O+30Si, 18O+28Si and 19F+27Al at 7 MeV/u e 16O+30Si at 8MeV/u, which have been measured at Legnaro National Laboratories with the GARFIELD+RCo detectors array. The idea behind this experiment is to evaluate the properties of the pre-equilibrium emission process in an energy regime close to the onset of such emission with the future project to carry out a following experiment of the same systems at higher bombarding energies, where the pre-equilibrium component is well assessed and may play a more important role.
This experiment finds employment in the wider framework of an extensive research campaign on pre-equilibrium emission of light charged particles from hot nuclei made by the NUCLEX collaboratio. The study of pre-equilibrium emitted particles is a useful tool to examine nuclear clustering analyzing the effects of possible cluster structures on the nuclear reactions.
After a theoretical and experimental introduction, the main analysis results are described: the quasi-complete events and complete events analysis; the study of selected evaporation residue channels; the evaluation of quantitative observables (BR and Q-value) of the major populated channels; the characterization of specific multiple (1, 2 and 3) alpha-channels.Lo scopo di questa tesi è descrivere l'analisi fatta sulle quattro reazioni: 16O+30Si, 18O+28Si e 19F+27Al a 7 MeV/u e 16O+30Si a 8 MeV/u, effettuate presso i Laboratori Nazionali di Legnaro con l'apparato di rivelazione GARFIELD+RCo. L'idea alla base di questo esperimento è di valutare le proprietà dei processi di emissioni di pre-equilibrio in un regime energetico prossimo alla soglia di tali emissioni, con il progetto futuro di effettuare un successivo esperimento con gli stessi sistemi a energie maggiori, tali che la componente di pre-equilibrio sia preponderante. Tale esperimento si colloca nella più ampia campagna sperimentale riguardante le emissioni di pre-equilibrio di particelle cariche leggere da nuclei eccitati, effettuata dalla collaborazione NUCLEX. Lo studio delle particelle di pre-equilibrio è uno strumento utile per studiare il clustering nucleare analizzando gli effetti che esso produce sulla dinamica di reazione. Dopo un'introduzione teorica e sperimentale, i principali risultati dell'analisi saranno esposti: le analisi degli eventi quasi-completi e degli eventi completi; lo studio di specifici canali di reazione relativi ai residui di evaporazione; l’analisi quantitativa di osservabili quali il branching ratio e il Q-valore; la caratterizzazione dei canali a più (1, 2 e 3) particelle alpha.
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Ibrahim, Taofiq Toyin. "A cluster study of the nuclei 212Po and 218Rn." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1299.
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Thesis (PhD (Physics))-University of Stellenbosch, 2009.ENGLISH ABSTRACT: A binary cluster model is used to investigate the properties of the ground state band of 212Po, modelled as a 208Pb-alpha core-cluster system. The results obtained using a microscopic corecluster potential are compared to those obtained with a purely phenomenological potential. The two potentials were found to exhibit similar surface behaviour and thus give similar predictions for the ground state alpha decay half-life. They however generate very different energy spectra, with the results from the phenomenological potential clearly superior. We optimize the phenomenological potential parameters, and propose an additional short range interaction to improve the underbinding generally found for the J¼ = 0+ ground state. We then investigate two possible scenarios for generating the negative parity states in 212Po. We find that both are necessary in order to produce low-lying negative parity states which are able to decay via electric dipole transitions to the positive parity states of the ground state band. Finally we present a novel calculation of the properties of the low-lying positive and negative parity states of 218Rn described as a doubly closed 208Pb core plus a 10Be cluster.
AFRIKAANSE OPSOMMING: ’n Binêre bondel model word gebruik om die eienskappe van die grondtoestands energie band van 212Po, te modeleer as ’n 208Pb-alpha kern-bondel sisteem te ondersoek. Die resultate verkry vanaf ’n mikroskopiese kern-bondel potentiaal word vergelyk met die wat verkry is met ’n suiwer fenomenologiese potentiaal. Die twee potentiale is verkry om dieselfde oppervlakte toestande voor te stel en gee sodoende dieselfde voorspellings vir die grondtoestand alpha verval halfleeftyd. Alhoewel dit baie verskillende energie spektra genereer, toon die resultate van die fenomenologiese potentiaal dat dit duidelik beter is. Ons optimiseer hierdie fenomenologiese parameters en stel ’n addisionele kort ry-afstands interaksie voor om die algemene ondergebondenheid wat oor die algemeen by die J¼ = 0+ grondtoestand voorkom, te verbeter. Ons ondersoek ook hierdie twee moontlike scenarios om die negatiewe pariteitstoestande in 212Po te genereer. Ons vind dat beide scenarios noodsaaklik is om laagliggende pariteitstoestande te produseer, sodat verval deur elektriese dipool oorgange na die positiewe pariteitstoestande van die grondtoestandsband moontlik is. Laagliggende positiewe en negatiewe pariteitstoestande, van die 218Rn wat beskryf word as ’n dubbelgeslote 208Pb kern en ’n 10Be bondel.
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Di, Vona Chiara 1981. "Nuclear DYRK1A :new insights into its role within the nucleus." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/283483.
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The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription machinery, which are directly modified on genomic loci. For the shuttling kinase DYRK1A (dual-specificity tyrosine-regulated kinase), most of its nuclear-associated functions can be explained by DYRK1A cytosolic activities, questioning a role for DYRK1A within the nuclear compartment. In the present study, through an unbiased proteomic approach the first “DYRK1A nuclear interactome” have been generated. DYRK1A interacts with several components of the basal transcriptional machinery as well as with the pre-mRNA processing machinery. Moreover, evidences uncovering a new role for DYRK1A as a transcriptional regulator of specific target genes have been generated. Genome-wide DYRK1A-chromatin analysis shows that the kinase is recruited to RNA polymerase II proximal promoters, via a highly conserved palindromic sequence, and also to RNA polymerase III-dependent promoters. Growth-dependent induction of the expression of a subset of target genes (protein coding and tRNAs) depends on DYRK1A protein levels and/or activity. In addition, downregulation of DYRK1A leads to a reduction in cell size. DYRK1A could therefore work by sitting on promoters of specific genes and act on different components of the basal transcription and/or mRNA processing machinery to modulate gene expression.Resultados recientes han puesto de manifiesto que la regulación de la expresión génica por proteína quinasas va mas allá de su modulación de la actividad de factores de transcripción, ya que tanto histonas como remodeladores de cromatina o componentes de la maquinaria basal de transcripción puedes ser sustratos de fosforilaciones directamente en regiones genómicas reguladoras. La proteína quinasa DYRK1A (dual-specificity tyrosine-regulated kinase) está presente tanto en el núcleo como en el citoplasma de células de mamífero, si bien la mayoría de sus actividades nucleares pueden ser explicadas por fosforilaciones que ocurren en el citosol, lo que ha planteado dudas sobre si esta quinasa posee funciones específicamente nucleares. En este trabajo, se ha definido el primer "interactoma" nuclear de DYRK1A mediante una aproximación proteómica no sesgada, que ha permitido mostrar que DYRK1A interacciona con componentes de la maquinaria basal de transcripción así como con complejos implicados en el procesamiento del pre-mRNA. Los resultados también han puesto de manifiesto un nuevo papel de DYRK1A como regulador de la transcripción de un grupo específico de genes relacionados con la traducción de proteínas. Análisis a nivel genómico de la presencia de DYRK1A en cromatina muestra que la quinasa es reclutada a regiones proximales de promotores dependientes de la RNA polimerasa II, mediante una secuencia palindrómica altamente conservada, así como a genes dependientes de la RNA polimerasa III. La inducción de la expresión de un grupo de estos genes diana (tanto codificantes como tRNAs) en respuesta a factores de crecimiento depende de DYRK1A. Además, la reducción en los niveles de DYRK1A provoca una reducción en el tamaño de las células. Los resultados permiten proponer un modelo por el que DYRK1A podría regular directamente la expresión de genes diana mediante la fosforilación, en regiones reguladoras promotoras, de diferentes componentes de la maquinaria basal de la transcripción y/o de los complejos proteicos implicados en el procesamiento del mRNA.
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Möller, Matthias [Verfasser]. "Antikaons in infinite nuclear matter and nuclei / von Matthias Möller." [Darmstadt] : [Univ.- und Landesbibliothek], 2007. http://d-nb.info/1000025136/34.
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Geßler, Stefanie [Verfasser]. "Hadron-Nucleus interactions in the nucleon resonance region / Stefanie Geßler." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1141053349/34.
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Kuprov, Ilya. "Chemically induced dynamic nuclear polarization of ¹â¹F nuclei." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422659.
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Brown, Daniel Edward. "Low temperature nuclear orientation studies of nuclei far from stability." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257942.
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Cunningham, Elizabeth Sarah. "The effect of spin-spin interactions on nucleon-nucleus scattering." Thesis, University of Surrey, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527010.
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Rybak, Karolina. "Predictive power of nuclear mean-field theories for exotic-nuclei problem." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00864240.
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This thesis is a critical examination of phenomenological nuclear mean field theories, focusing on reliable description of levels of individual particles. The approach presented here is new in the sense that it not only allows to predict the numerical values obtained with this formalism, but also yields an estimate of the probability distributions corresponding to the experimental results. We introduce the concept of 'theoretical errors' to estimate uncertainties in theoreticalmodels. We also introduce a subjective notion of 'Predictive Power' of nuclear Hamiltonians, which is analyzed in the context of the energy spectra of individual particles. The mathematical concept of 'Inverse Problem' is applied to a realistic mean-field Hamiltonian. This technique allows to predict the properties of a system from a limited number of data. To deepen our understanding of Inverse Problems, we focus on a simple mathematical problem. A function dependent on four free parameters is introduced in order to reproduce 'experimental' data. We study the behavior of the 'fitted' parameters, their correlation and the associated errors. This study helps us understand the importance of the correct formulation of the problem. It also shows the importance of including theoretical and experimental errors in the solution.
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Davidson, Walter Fraser. "Experiments on the nuclear structure of 168Er and other heavy nuclei." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/13579.
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A comprehensive series of radioactive source, accelerator-based and reactor-based experiments to determine the structure of some 40 heavy nuclei beyond mass value 100, especially on the nucleus 168Er, is described in the first two Sections of the thesis. In Section I the results of an extensive measurement programme on 168Er involving (n,γ) and (n,e-) reactions, and single- and two- nucleon transfer reactions, are described. The neutron capture studies were conducted on the curved crystal-, beta-, and pair formation-spectrometers at the High Flux Reactor of the Institut Laue-Langevin, and the particle transfer experiments at the Mcmaster University Tandem Van de Graaff accelerator. The final level scheme deduced from all experiments incorporates the 128 levels identified into 37 rotational bands (for 4 of them, just the bandheads), making 168Er arguably the most fully characterized nucleus known. An IBA model interpretation of the collective states and decay patterns reproduced the observed level scheme well, especially predicting the observed preferred γ-decay from the β- to the γ-band. A discussion is given of various, often competing, theoretical treatments which these experimental results triggered. The results of the large body of particle transfer data from the experiments compared very favourably with the predictions of the Soloviev model. Section II comprises radioactivity studies of isotopes in the actinium chain carried out at the University of Manitoba; in-beam γ-ray spectroscopy of high spin states in rare earth nuclei following (α,xn) reactions performed at the Kernforschungsanlage Jülich cyclotron; and neutron capture studies on heavy nuclei carried out at the Institut Laue-Langevin. Significant advances from the cyclotron experiments included many of the first examples of the "backbending" effect of the nuclear moment of inertia at high spins in nuclei around A=160 and interpretation of observed regularities in the γ-ray spectra in both odd-A and even-A Hg isotopes in terms of the rotational alignment model.
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Urban, Jeffry Todd. "Nuclear magnetic resonance studies of quadrupolar nuclei and dipolar field effects." Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/836811-joXo6p/native/.
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Thesis (Ph.D.); Submitted to the University of California, Berkeley, CA (US); 21 Dec 2004.Published through the Information Bridge: DOE Scientific and Technical Information. "LBNL--56768" Urban, Jeffry Todd. USDOE Director. Office of Science. Office of Basic Energy Sciences (US) 12/21/2004. Report is also available in paper and microfiche from NTIS.
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Morris, David D. "Nucleon pairing approximations in the nuclear shell model." Tallahassee, Fla. Florida State University, 2009. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/228755.
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Antić, Sofija [Verfasser], Karlheinz [Akademischer Betreuer] Langanke, and Gabriel [Akademischer Betreuer] Martinez-Pinedo. "Generalized relativistic mean-field model with non-linear derivative nucleon-meson couplings for nuclear matter and finite nuclei / Sofija Antić ; Karlheinz Langanke, Gabriel Martinez-Pinedo." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2018. http://d-nb.info/1153546388/34.
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Ghazi, Moradi Farnaz. "Experimental Nuclear Structure Studies in the Vicinityof the N = Z Nucleus 100Sn and in the ExtremelyNeutron Deficient 162Ta Nucleus." Doctoral thesis, KTH, Kärnfysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141421.
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This work covers spectroscopic studies of nuclei from different regions of the Segré chart whose properties illustrate the delicate balance between the forces in the atomic nucleus. Studies of nuclei far from stability offer new insights into the complex nucleon many-body problem. In nuclei with equal neutron and proton numbers (N = Z), the unique nature of the atomic nucleus as an object composed of two distinct types of fermions can be expressed as enhanced correlations arising between neutrons and protons occupying orbitals with the same quantum numbers. The bound N = Z nuclei with mass number A > 90 can only be produced in the laboratory at very low cross sections. The related problems of identifying and distinguishing such reaction products and their associated gamma rays have prevented a firm interpretation of their structure even for the lowest excited states until recently. In the present work the experimental difficulties of observation of excited states in the N = Z = 46 nucleus 92Pd have been overcome through the use of a highly efficient, state-of-the-art detector system; the EXOGAM-Neutron Wall-DIAMANT setup, and a prolonged experimental running period. The level spacings in the ground state band of 92Pd give the first experimental evidence for a new spin-aligned neutron-proton (np) paired phase, an unexpected effect of enhanced np correlations for N = Z nuclei in the immediate vicinity of the doubly magic nucleus 100Sn. Excited states in 94Ru and 95Rh nuclei close to the double magic shell Z = N = 50 have been studied in order to untangle the ambiguity of the spin and the parity of the lowest-lying states. The observed yrast structures are compared to results of large-scale shell model (LSSM) calculations and the strengths of hindered E1 transitions are used as a sensitive test of the LSSM parameters. The effect of single-particle-hole excitations is discussed in terms of the strength of hindered E1 transitions. Excited states of the odd-odd nucleus 162Ta have been observed using the JUROGAM/RITU experimental set-up. This nucleus is located in a transitional region in the nuclide chart which is between near-spherical nuclei and well-deformed nuclei, offering the possibility to study the emergence of collective phenomena and nuclear deformation (in particular the degree of triaxiality). The results, which are interpreted in the framework of the cranked shell model with total Routhian surface calculations, suggest an almost axially symmetric nuclear shape. The energy staggering between the signature partners of the yrast rotational bands has been deduced for eight odd-odd isotopes in the neighborhood of 162Ta nucleus and the special observed feature of signature inversion for these nuclei is discussed.QC 20140217
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Nemulodi, Fhumulani. "Investigation of the 2+ Hoyle state candidates in 12C." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96714.
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Lerman, Louis. "On the symmetry of nuclear identity between relativistic primary and secondary nuclei." [S.l. : s.n.], 2002. http://archiv.ub.uni-marburg.de/diss/z2002/0105/.
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Chalhoub, Oussama Abd. "Nuclear structure of the odd-odd nuclei [104'Rh] and [108'Ag]." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/37961.
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Macadangdang, Joan Karla. "Nuclear and Cytoskeletal Prestress Govern the Anisotropic Mechanical Properties of the Nucleus." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23310.
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Physical forces in the cellular microenvironment play an important role in governing cell function. Forces transmitted through the cell cause distinct deformation of the nucleus, and possibly play a role in force-mediated gene expression. The work presented in this thesis drew upon innovative strategies employing simultaneous atomic force and laser-scanning confocal microscopy, as well as parallel optical stretching experiments, to gain unique insights into the response of eukaryotic cell nuclei to external force. Non-destructive approaches confirmed the existence of a clear anisotropy in nuclear mechanical properties, and showed that the nucleus' mechanical response to extracellular forces is differentially governed by both nuclear and cytoskeletal prestress: nuclear prestress regulates shape and anisotropic deformation, whereas cytoskeletal prestress modulates the magnitude and degree of deformation. Importantly, the anisotropic mechanical response was conserved among diverse differentiated cell types from multiple species, suggesting that nuclear mechanical anisotropy plays an important role in cell function.
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Seely, Jason (Charles Jason). "Precise measurement of the nuclear dependence of structure functions in light nuclei." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/39559.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2006.Includes bibliographical references (leaves 171-174).
The EMC effect has been with us for over 20 years. During this time, the nuclear dependence of the structure functions, and therefore the underlying quark distributions, has been studied with much success. However, the bulk of the experimental effort has been to measure the effect in heavy nuclei where it has the same zBj dependence and differs only in magnitude. Calculations predict large differences in both the magnitude and zBj-dependence of the EMC effect in 3He and 4He and precise measurements of the EMC effect in these nuclei could be used to distinguish between existing models. E03-103 measured the inclusive electron scattering cross-section on 1H, 2H, 3He, and 4He, as well as the heavier targets Be, C, Cu, and Au. This thesis describes the experiment in detail and presents results for 3He, 4He, and carbon. These data provide the first measurement of the EMC effect in 3He above xBj > 0.4, and improve upon the existing measurement of the effect in 4He.
by Jason Seely.
Ph.D.
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Okamura, Kazuya. "Algebraic and Statistical Approach to Infinite Quantum Systems." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188458.
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Tokiyasu(Okamura), Atsushi. "Search for the K-pp bound state using the d(γ,K+π-)X reaction at Eγ=1.5-2.4 GeV." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188483.
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Stowell, John Patrick. "Effects of nucleon and nuclear structure in neutrino interactions." Thesis, University of Sheffield, 2019. http://etheses.whiterose.ac.uk/22623/.
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As the precision of neutrino experiments is steadily improving, new data is beginning to highlight problems with current models of neutrino interactions. There exist several unresolved tensions within the global neutrino scattering dataset, and faced with these problems, experiments are forced to turn to data-driven models with errors that can span the spread in experimental observations. The NUISANCE software package was developed to provide a flexible framework for the community to use in the building of these models. This thesis focuses on the extraction of empirical model corrections, to account for several observed tensions in the global scattering dataset, that could have an impact on the T2K oscillation analysis. Charged current neutrino interaction measurements from MiniBooNE are used to study systematic shifts when tuning the NEUT event generator under different sterile neutrino mixing hypotheses. The results are used to derive an error rescaling method for use in future T2K short baseline oscillation fits. Alternative models for the quasi-elastic axial form factor are developed, and implemented into NEUT. Data from neutrino-deuterium scattering is used to test each model's implementation, and extract systematic uncertainties for input to the T2K long baseline oscillation analysis. In addition, NEUT predictions are compared to CC-inclusive data from the MINERvA experiment, highlighting a clear deficiency in its CC0π model. An empirical correction to both the quasi-elastic and multi-nucleon contributions is developed to account for this. Exclusive data from MINERvA is also used to test the GENIE event generator's pion production model. The standard GENIE dials are found to provide insufficient coverage of the chosen datasets, and clear tensions are found between these results and earlier tunings to deuterium scattering data. An ad-hoc model correction is developed to account for disagreements in the muon scattering angle distributions, reducing the tensions in the joint fits.
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Amore, Paolo. "Modifications of the nucleon properties in the nuclear medium." W&M ScholarWorks, 2000. https://scholarworks.wm.edu/etd/1539623982.
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In this thesis we consider the possible modifications of the properties of the nucleon inside a nucleus. This problem is studied by applying the Wigner-Seitz approximation to different effective field theory models of the nucleon based on the underlying symmetries of QCD. The Wigner-Seitz approximation reduces the complex many-body problem to an effective one-body problem. By following this approach we calculate the static properties of the nucleon in the nuclear medium in both the Skyrme and the chiral quark soliton models. We also use the same chiral quark-soliton model to calculate the modification of the quark distribution functions measured in deep inelastic electron scattering when a nucleon is inside the nucleus.
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Colaux, Henri. "Investigating sensitivity improvement methods for quadrupolar nuclei in solid-state nuclear magnetic resonance." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/9628.
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The study of quadrupolar nuclei using NMR spectroscopy in the solid state significantly increased in popularity from the end of the 20th century, with the introduction of specific methods to acquire spectra free from the effects of the quadrupolar interaction, that results in broadened lineshapes that cannot be completely removed by spinning the sample at the magic angle (MAS), unlike most of the other interactions present in the solid state. The first technique which allows, without any specific hardware, the removal of this broadening has been the Multiple-Quantum MQMAS experiment. The method quickly gained a popularity within the NMR community, with numerous successful applications published. However, the multiple-quantum filtration step in this experiment relies on severely limits sensitivity, restricting application to the most sensitive nuclei. Extending the applicability of MQMAS to less receptive nuclei requires the use of signal improvement techniques. There are multiple examples of such approaches in the literature, but most of these require additional optimisation that may be time-consuming, or simply impossible, on less receptive nuclei. This work introduces a novel signal improvement technique for MQMAS, called FAM-N. Its optimisation is solely based on density matrix simulations using SIMPSON, implying no additional experimental optimisation is required, while improving the signal in MQMAS spectra by equivalent or higher amounts than other common methods. In order to prove the applicability of this method on virtually any system, FAM-N has been investigated by simulation, and tested experimentally using a number of model samples, as well as samples known to be challenging to study by NMR. This work also explores other aspects of NMR spectroscopy on quadrupolar nuclei. Adiabatic inversion of the satellite populations can be performed to improve the central transition signal in static or MAS spectra. A range of methods has been tested and compared, with particular attention given to hyperbolic secant-shaped pulses, for which its performance have been described. Finally, cross-polarisation from a spin I = 1/2 nucleus to a quadrupolar nucleus has been investigated. After reviewing the theory for the static case, simulations have been performed under MAS in order to identify the conditions for efficient magnetisation transfer, with applications in spectral editing or for the combination with MQMAS.
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Prokofiev, Alexander. "Nucleon-Induced Fission Cross Sections of Heavy Nuclei in the Intermediate Energy Region." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5009-1/.
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Garutti, Erika. "Nuclear effects in semi-inclusive deep-inelastic scattering off 84Kr and other nuclei." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87247.
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Hooper, Thomas J. N. "Solid state nuclear magnetic resonance on quadrupolar nuclei in disordered catalysis based materials." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/101212/.
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The behaviour of a catalyst is intrinsically linked to its structure and, therefore, accurate structural refinements are desired to tune their overall function. Higher functional demands on catalysts systems, require more complex disordered materials which are inherently difficult to characterise with conventional analytical techniques. Solid state NMR is an excellent probe of local order and, hence, is utilised in this thesis for the structural determination of several catalytic related materials. The first direct105 Pd solid state NMR measurements of diamagnetic (K2PdCl6, (NH4)2PdCl6 and K2PdBr6) complexes is reported, thereby introducing an effective 105 Pd chemical shift ranges with respect to the newly proposed 105 Pd chemical shift reference (0.33 M H2PdCl6(aq)). The enormous 105 Pd quadrupolar moment, makes the interaction very sensitive to small structural distortions as demonstrated by the measurable quadrupolar parameters for the three complexes, despite the high symmetry octahedral Pd coordination. The detected deviation from a cubic symmetry, was corroborated by XRD PDF analysis. The 105 Pd quadrupolar parameters are shown to be more sensitive to minute disorder than conventional XRD and other quadrupolar nuclei NMR. Ambient temperature 105 Pd NMR observations of Pd metal determined the Knight shift as K = −3.205 ± 0.006 %, where variations in the 105 Pd Knight shift allowed for detection of defects in the cubic metal structure and for differentiation of Pd nanoparticle sizes. The developed 105 Pd NMR methodology was then applied in a multi-technique structural investigation of doped Pd catalysts, that confirmed the interstitial location of the dopants. The use of the newly developed structure-generation software, supercell, in combination with GIPAW-DFT calculations and solid state NMR, is shown to be a thorough tool for structural determination of disordered materials. The methodology is applied to two phases of the aluminosilicate mullite (3:2 mullite and 2:1 mullite), and provides complete assignment of the 17O,27 Al and 29 Si NMR spectra. The distribution of AlO4/SiO4 sites in the mullite structure is shown to be random, proving the presence of SiO4 moieties in the tritetrahedral (T3O) environments. The observation of said moieties directly contradicts Loewenstein’s avoidance principle. Additionally, a quasi-tetrahedral site with an additional long bond ((Al/Si)O4+1) is discovered and a vacancy adjacent three-coordinated Al site (AlO3[]) is proposed. The findings from this investigation are then applied to the 27 Al MQMAS study of boron doped mullites, providing additional evidence for the AlO3[]motif. A thorough 11 B and 27 Al solid state NMR investigation was undertaken on three series of aluminium borate phases (A9B2, A2B and metastable Al6-xBxO9 (where 1 ≤ x ≤ 3)) with varying Al/B ratios. A solid solution of AlO4 and BO4 tetrahedra was discovered in all three phases (to varying extents), justifying the conflicting compositional/structural reports present in the literature. Differences in the crystallinity of commercially available, sol-gel synthesized, and solid state synthesised A9B2 samples were documented. The solid state NMR study of the disordered phases, A2B and metastable Al6-xBxO9, utilised multiple fields and MQMAS measurements to constrain the simulation of the 1D spectra, which allowed for complete assignment of the structure and corrected previous erroneous reports. An AlO4+1 site, analogous to the discovered mullite environment, is found in both disordered phases.
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Rovnyak, David S. (Davis Sherman) 1971. "Solid-state nuclear magnetic resonance of quadrupolar nuclei with applications to biological solids." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85294.
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CARVALHO, LUIZ S. "Frequencia de danos no nucleo por blecaute em reator nuclear de concepcao avancada." reponame:Repositório Institucional do IPEN, 2004. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11147.
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Made available in DSpace on 2014-10-09T12:48:53Z (GMT). No. of bitstreams: 0Made available in DSpace on 2014-10-09T14:01:14Z (GMT). No. of bitstreams: 1 09627.pdf: 6224254 bytes, checksum: 0192b8abd2aed7811607e803516e20a7 (MD5)
Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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Fraser, Paul R. "Development and application of a multi-channel algebraic theory for nucleon-nucleus scattering /." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/3597.
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Norrick, Anne. "A Measurement of Nuclear Effects in Deep Inelastic Scattering in Neutrino-Nucleus Interactions." W&M ScholarWorks, 2018. https://scholarworks.wm.edu/etd/1550153893.
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Neutrino-Nucleus Deep Inelastic Scattering (DIS) events provide a probe into the structure of nucleons within a nucleus that cannot be accessed via charged lepton-nucleus interactions. The MINERvA experiment is stationed in the Neutrinos from the Main Injector (NuMI) beam line at Fermi National Accelerator Laboratory. With the recent increase in average neutrino energy and the greatly increased intensity of the NuMI beam line, projected sensitivities for DIS cross section ratio analyses using MINERvA's suite of nuclear targets (C, CH, Fe and Pb) are greatly increased. an analysis of theMINERvA DIS data on carbon, iron, lead, and plastic has been conducted for muon neutrino interactions with a muon angle less than 17 degrees. Results are presented as a differential cross section with respect to neutrino energy and the Bjorken-x scaling variable.
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ZILIANI, SARA. "COMPREHENSIVE INVESTIGATION OF LIGHT NEUTRON-RICH NUCLEI TO TEST MODERN NUCLEAR THEORETICAL MODELS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/885740.
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Light nuclei, in particular the ones on the neutron-rich side of the valley of stability, represent a fertile ground to look for new experimental evidence, which can be exploited to benchmark theoretical approaches. In this Thesis we provide an experimental investigation of neutron-rich nuclei from boron to oxygen, employing state-of-the-art experimental techniques and detection systems. Novel information is collected and compared with the most advanced theoretical predictions currently available.
The research activity described in this work has been developed on three levels, each associated to a different research line, that mirror the characteristic structure of a nucleus: bound states below the particle emission thresholds, near-threshold states and unbound resonances. In fact, the first line of research aims at the investigation of bound states in neutron-rich C, N and O isotopes, the second focuses on near-threshold resonances (11B as a specific case), and the third on stretched unbound states in the continuum of 13C, 14N and 16O. Altogether, a rather comprehensive body of experimental information will be discussed and confronted with some of the most advanced theoretical interpretations currently available for describing light atomic nuclei, such as ab initio approaches and Shell Model including the coupling to the continuum.
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FANTUZI, Mauro. "Nuclear Spectroscopy near the proton drip-line in the Lanthanide region:the 122La nucleus." Doctoral thesis, Università degli Studi di Camerino, 2007. http://hdl.handle.net/11581/401903.
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One of the most exciting subjects in contemporary nuclear physics is the study of nuclei at the limits of stability with respect to particle emission. Recently, there has been an intensive experimental activity in measuring proton decay and a large variety of proton emitters were observed in the region of nuclei with 50 minus Z minus 82. Very recently, the proton radioactivity from 117La and 121Pr has been identified and the decay rate deviates significantly from calculations assuming spherical configurations, thus indicating the onset of large deformations in the drip line nuclei below Z = 69. Predictions by the microscopicmacroscopicmass model and by relativistic mean field calculations support these experimental results and suggest the position of the proton drip line. The lifetimes of the proton-decaying isomers are extremely sensitive to the orbital angular momentum ` of the emitted proton and can vary over several orders of magnitude when changing the angular momentum of the occupied orbital. The position of certain orbitals at the Fermi surface depends strongly on the beta2 deformation. It is therefore very important to determine the quadrupole deformation of the nuclei at and beyond the proton drip line, in order to locate the orbitals close to the Fermi surface and to estimate the lifetime of the isomers, which is essential when looking for new proton emitters. The deformation of the nuclei at the proton drip line in the A 130 mass region can be experimentally tested by comparing the lifetimes of proton emitters with theoretical predictions and by investigating the level structure of particle bound nuclei close to the drip line. For Z = 57 the proton drip line is predicted to correspond to the isotope 118La. The lightest La nucleus for which spectroscopic information has been published is 124La . This thesis bescribes an experiment realised to identify for the first time excited states of the doubly-odd nucleus 122 57 La65. Another aspect that make particularly interesting a study of these nuclei is a well-established phenomenon in two-quasiparticle rotational bands in odd-odd nuclei: the signature inversion. Despite the observation of signature inversion in many different nuclei, and numerous theoretical interpretations, a satisfactory explanation of the phenomenon has yet to be found. We want verify if the experimental level scheme of 122La is in agreement with the systematics of the other nuclei in this mass region. The common feature relating the studies of these neutron deficient nuclei is that they are populated with extremely low cross section and require special techniques to be identified. The standard efficient way to achieve this is the use of arrays of high-purity germanium detectors coupled to specific ancillary devices for their selection. Our experiment has been performed at the Legnaro National Laboratory (LNL) where heavy-ion fusion-evaporation reaction 40Ca(@ 200 MeV)+92Mo was performed to establish the scheme of 122La by using the GASP -ray spectrometer in conjunction with the ancillary charged-particle ISIS detector and the Neutron Ring. This experimental set-up led to numerous achievements in the A 130 mass region. Chapter 1 introduces to the physics of the nuclei close and beyond to the proton drip-line. In Chapter 2 we will briey see the various theoretical models created to describe several types of nuclear excitations and discuss in more detail the cranking model. Chapter 3 describes the experimental techniques of -ray spectroscopy and the setup used for the present measurement. In Chapter 4 the steps followed in the sorting of the raw data to produce particle-gated matrices are described, together with the techniques used to select the different reaction channels and to clean the spectra. Chapter 5 shows the systematic features of the rotational bands of the A 130 proton rich odd-odd nuclei. Chapter 6 will be devoted to the construction of the decay scheme and to the spins assignments, performed through the analysis of gated matrices, transition intensities, DCO, and the comparison with the systematics of the La isotopes. Finally, in Chapter 7, the results are discussed in the light of the deduced experimental quantities like single-particle spin alignment, dynamic moments of inertia, signature splitting, and B(M1)=B(E2) branching ratios to assign the Nilsson orbitals to the found bands.
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Shirinda, Obed. "Signature splitting and inversion in the 186-194 Au Nuclei predicted by the total routhian surface (TRS) and cranked shell model (CSM) calculations." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6814_1255091175.
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The nearly oblate deformed Au nuclei show rotational bands built on multi quasiparticle excitations [Bou89, Bou92, Gue03, Gue01, Ven92]. Several of these bands are built on rotationally aligned high-j proton and neutron excitations. In many cases bands consisting of two or three signature partner E2 sequences are observed. For some fo these bands signature inversion is found and this feature gives a great challenge to the theoretical models. In this study the researcher performed TRS and CSM calculations for all high-j rotational bands in the p186-194s Au nuclei aiming to predict the signature splitting and inversion phemomena, alignments, gains in alignments, gains in alignment and band crossing frequencies observed.
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MAZZOCCA, MATTEO. "Ruolo dell'organizzazione nucleare nel meccanismo di ricerca e di regolazione genica mediata da p53." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/133069.
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Un aspetto irrisolto in biologia molecolare è come l'organizzazione del nucleo regoli l'espressione genica. Nelle sue primissime fasi, l’espressione genica richiede che fattori di trascrizione scansionino il genoma -fra una miriade di DNA non specifico- per trovare geni specifici, un processo che culmina con l'associazione a promotori ed enhancer. I batteri hanno sviluppato speciali meccanismi per eludere l'effetto "sequestrante" del DNA non specifico e accelerare la ricerca, rendendo il processo estremamente efficiente. Non è noto se fattori di trascrizione eucariotici condividano meccanismi simili, né se il nucleo formi compartimenti che facilitano il loro reclutamento. Studi recenti in cellule umane suggeriscono che i fattori di trascrizione regolino il loro processo di ricerca attraverso interazioni deboli con l'ambiente circostante, ma non è chiaro con quali compartimenti nucleari.
In questo studio caratterizziamo il meccanismo di ricerca di p53, un fattore di trascrizione umano con importanti funzioni antitumorali, che regola molteplici vie di segnalazione a seguito di danno al DNA, come ad esempio l'arresto del ciclo cellulare e l'apoptosi. Per affrontare questo problema applichiamo una nuova tecnologia di imaging in vivo, che permette di seguire in tempo reale il meccanismo di ricerca di p53 in vari compartimenti nucleari. L'approccio combina una tecnica a singola molecola (single molecule tracking, SMT) -per studiare le interazioni di singole molecole di p53 nel nucleo- con un metodo per mappare compartimenti nel nucleo ad alta risoluzione (multifocal structured-illumination, mSIM).
I nostri risultati indicano che p53 "percepisce" la conformazione dell'ambiente nucleare attraverso contatti mediati dalle sue regioni intrinsecamente disordinate. Queste interazioni guidano p53 attraverso compartimenti di cromatina a diversa permeabilità, portandola rapidamente sui suoi geni target per regolarne l'espressione.A fundamental question in molecular biology is how the organization of the cell nucleus regulates gene expression. In its first steps, gene regulation requires transcription factors (TFs) to scan the genome -among a myriad of DNA random sequences- and find their targets, a process culminating with the association to specific promoters and enhancers. Bacteria have evolved special molecular mechanisms to elude the ‘sequestering’ effect of random DNA and speed up the TF search, making gene regulation extremely efficient. Whether eukaryotic TFs share similar mechanisms, how they find and selects their targets and whether the nucleus define local compartments that may facilitate or exclude their recruitment, is poorly understood. Recent evidence points out that TFs can engage weak and dynamic interactions with the surrounding environment, modulating the search process, but it is unclear what nuclear substructures are involved. In this work we characterize how the human tumor suppressor p53 – an important TF regulating multiple pathways in response to DNA damage such as cell cycle arrest, senescence and apoptosis – searches for its target genes in the cell nucleus, and how nuclear organization controls this process. We apply a novel fluorescence live imaging technology to follow in real-time the search process of p53 through nuclear compartments. The approach combines single molecule tracking (SMT) -to study the dynamic interactions in living nuclei of individual p53 molecules- with multifocal structured-illumination (mSIM), to map distinct compartments in the nucleus at high resolution. We find that p53 ‘perceives’ the conformation of the nuclear environment through contacts mediated by its intrinsically disordered regions (IDRs). These interactions guide p53 through chromatin compartments of different permeability, to efficiently locate p53 targets and induce gene expression.
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Galaviz, Redondo Daniel [Verfasser]. "Systematic study of alpha-nucleus potentials for neutron-deficient nuclei and its astrophysical applications / Daniel Galaviz Redondo." Aachen : Shaker, 2004. http://d-nb.info/1172614768/34.
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Nedjadi, Youcef. "Elektroweak tests of the relativistic nuclear scalar-vector model." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236201.
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Kwan, Elaine. "Production of nuclei near the neutron drip-line by projectile fragmentation." Diss., Connect to online resource - MSU authorized users, 2006.
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Thesis (Ph. D.)--Michigan State University. Dept. of Physics and Astronomy, 2006.Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references (p. 124-130). Also issued in print.
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Gosling, P. "Nuclear quadrupole double resonance : Detection of low frequency quadrupolar nuclei using fluorine and hydrogen." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375258.
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Hlophe, Linda D. "Separable Representation of Nucleon-Nucleus Optical Potentials as Input to (d,p) Reaction Calculations." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1467319283.
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