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Stubblefield, Shannon. "The nude female performer." Thesis, Mills College, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1562505.
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A live nude female performer can occupy a powerful identity equal to a man because she willingly places herself in front of an audience. She commits to this state of profound vulnerability as a means of gaining ownership of her body that men by virtue of their power in society take for granted. The female body occupies physical space, unlike how a body image seen on a television or in a magazine does. The actuality of the live female nude creates a transformation from the purely sexualized body to an authentic female nude body. This authentic female nude body, via her control of her physicality, is a “loud” and often rejected body. The acknowledgement of her authenticity is an acknowledgement of her power and this is common ground on which the female audience member and performer can relate intersubjectively. On the surface, it seems the most effective solution to eliminating objectification and this obstruction of the female body would be to take focus away from her body. Yet paradoxically, female subjects have altered these culturally shaped identity norms of objectification through nude performance, liberating the hyper-sexualized projections attached to the female body and replacing them with symbols of innocence, creativity and power.
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Filgueiras, Tatiana Pereira. "RT-JADE." Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/95866.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Automação e Sistemas, Florianópolis, 2011Made available in DSpace on 2012-10-26T06:39:32Z (GMT). No. of bitstreams: 1 294604.pdf: 2124450 bytes, checksum: 0b81771135979b58563a2b4d4c5675c3 (MD5)
Com o crescimento das redes de computadores mundiais e o aumento do uso de aplicações distribuídas, surge um aumento significativo no tráfego de dados no enlace, demonstrando, assim, a necessidade de primoramento - ou substituição das atuais técnicas de transmissão de dados - do modelo tradicional cliente-servidor. A tecnologia de agentes móveis tem sido alvo de diversas pesquisas na área, por permitir que apenas um código mova--se entre os nós da rede e retorne com os resultados, diminuindo, assim, a carga na rede. Para que um agente móvel possa cumprir sua missão, é necessário que se atenda a um deadline. Entretanto, em um sistema distribuído, há a possibilidade de concorrência por um mesmo recurso. Tratar de forma adequada tal concorrência é de suma importância, especialmente em um ambiente em tempo real. Em face disso, um modelo de execução em que agentes móveis disputam um mesmo recurso em um mesmo host é proposto, o RT-JADE: uma extensão de middleware que possibilita agentes móveis concorrentes cumprirem suas missões, usando métodos de escalonamento em tempo real sobre a plataforma JADE. A eficácia do modelo proposto foi demonstrada através de simulações e comparações entre diversas políticas de escalonamento, com distintas cargas de trabalho (quantidade de agentes concorrentes).
With the growth of worldwide computer networks and increased use of distributed applications, there is a significant increase in data traffic in the link, thus demonstrating the need for improvement # or replacement of existing techniques for data transmission # of the traditional client-server one. The mobile agent technology has been the subject of several researches in area, because it only allows a code to move between network nodes and return with the results, reducing the network#s load. For a mobile agent to accomplish its mission, it is necessary for it to meet a deadline. However, in a distributed system there is the possibility of competition for the same resource. Treating such competition adequately is very important, especially in a real-time environment. In this view, an execution model in which mobile agents compete for the same resource in the same host is proposed # RT-JADE: a middleware extension that allows concurrent mobile agents to achieve their missions, using real-time scheduling methods on the JADE platform. We demonstrate the effectiveness of the proposed model through simulation and comparison of different scheduling policies under different workloads (number of competing agents).
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Tolley, Rebecca. "Review of Exposed: The Victorian Nude." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etsu-works/5712.
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Pennings, Mark W. "Charles Wheeler and the nude in Australia." Connect to thesis, 1991. http://repository.unimelb.edu.au/10187/1432.
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The place for Charles Wheeler’s nudes in Australian art history has not been adequately gauged by art historians. He was one of Australia’s most notable painters of the nude, not perhaps because his vision was particularly inventive or original, but rather because he was an important, conservative conduit of that European tradition. Wheeler was very popular with the buying public over many decades, but success with his nudes was fundamentally a critical one. The positive response to Wheeler’s nudes, paintings which combined elements of the academic tradition and more fashionable conventions, presents an intriguing reflection on the nature of art criticism in Australia. The style of Wheeler’s discourse is indebted not only to late nineteenth century British models, as it was represented in the writings of critics such as R.A.M. Stevenson, who was primarily concerned with technique, but also to current debates about art and morality. One of the determining characteristics of this discourse was an interest in defining the limits between naked and nude. Critics were particularly concerned to protect the nude as a genre against moral attack by refusing to engage in a discussion of its sensual aspects. While the public was keen to debate the moral problems associated with the nude, the critics were anxious to avoid these issues. They felt that questions of morality were not central to artistic merit, and sensed that by engaging in discussion of this kind, the nude was on danger of being brought into disrepute.
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Smith, Alison. "The nude in Victorian painting : 1850-1885." Thesis, Courtauld Institute of Art (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297081.
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Wyatt, Malinda. "William Rimmer's Concept of the Heroic Male Nude." VCU Scholars Compass, 1986. http://hdl.handle.net/10156/1443.
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Assano, Mauro Eidi Villela. "Guides for CCS to UML-RT and UML-RT to CCS conversions." Instituto Tecnológico de Aeronáutica, 2009. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=940.
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CCS (Communicating and Concurrent Systems) is the process algebra to specify and verify concurrent and communicating systems. This work proposes a transformation guide of the CCS equations into to the UML-RT (Unified Modeling Language for Real-Time) model and a transformation guide of the UML-RT model into a set of CCS equations. The UML-RT model is a software design language, which supports code generation and the construction of executable systems. The UML-RT is an UML extension, and it does not have a formal semantics; therefore it is not possible to verify UMLRT models. The transformation guide of UML-RT models into CCS equations allows verifying the models. We argue that the transformation of CCS models into UML-RT models allows an alternative way of correctly building systems. This work details the transformation guides from CCS equations to UML-RT models and from UML-RT models to CSS equations and it discusses the limitations and benefits.
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Blount, Jennifer Lynn. "The black male nude a study of John Singer Sargent's Thomas McKeller nude within the context of nineteenth-century art and culture /." Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009m/blount.pdf.
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Thesis (M.A.)--University of Alabama at Birmingham, 2009.Title from PDF title page (viewed Sept. 2, 2009). Degree earned with the cooperation of additional faculty from the University of Alabama. Includes bibliographical references (p. 88-91).
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Smither, Devon. "Identity crisis : the nude in 1930s modern Canadian art." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27693.
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In their unwillingness to fully assimilate or relate the human body to its surroundings, many artists who painted nudes in the 1930s in Canada found their works the subject of censure and moral debate. Rather than becoming the site of praise for a new Canadian sensibility in the visual arts, the nudes painted in this period would not come to be associated with a uniquely Canadian artistic practice, and the genre failed to assume a pivotal place within the canon of Canadian art history. Viewers could not imagine themselves as heroic pioneers in front of a painting like Lilias Torrance Newton’s Nude (1933), or could they see anything distinctly modern and revolutionary in its execution that would allow them to hold up such an image as an example of an inherently Canadian art. The nude in Canada did not incite the admiration of an art-going public who instead came to associate a national art movement with the landscape paintings of the Group of Seven. Censored, debated, praised, and criticized, the nude genre ultimately failed to have the same impact as landscape painting on the visual arts in Canada.
Landscape painting was able to mediate the relationship between the natural world and its human inhabitants in a way not offered by the nude or figurative painting. In 1916, Saturday Night magazine published an article jocularly recounting how the typical Canadian artist was a “husky beggar” who pulled on a pair of Strathcona boots and set off into the woods with a rifle, a paddle, and enough baked beans for three months. Such assertions would lead a critic like Barker Fairley to complain later that, “[N]ot one Canadian in a hundred goes into an art gallery looking for anything but hills and trees and lakes and clouds and flowers and fruit.” Ultimately, the nude was not able to provide a collective viewing position that could embody a national sentiment. It was unable to penetrate the Canadian consciousness in a way that would win it a place alongside the rolling topography and pristine lakes of the Group of Seven.
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Missia, Frano G. "Painting the nude by male artists in Western art /." Access Digital Full Text version, 1993. http://pocketknowledge.tc.columbia.edu/home.php/bybib/11396210.
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Thesis (Ed.D.)--Teachers College, Columbia University, 1993.Typescript; issued also on microfilm. Sponsor: Justin Schorr. Dissertation Committee: Rene Arcilla. Includes bibliographical references (leaves 112-113).
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Bernardo, Carina Susana Diogo. "Establishment of direct bladder cancer xenografts in nude mice." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7249.
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Mestrado em Biomedicina MolecularA cistectomia radical e o tratamento standard do carcinoma urotelial invasivo da bexiga, contudo, cerca de metade dos paciente apresentam recidivas ap os a cirurgia e necessidade de quimioterapia sist emica. Pacientes com tumores invasivos da bexiga com caracter sticas id^enticas apresentam varia c~oes signi cativas na evolu c~ao natural da doen ca e resposta ao tratamento, re ectindo a composi c~ao heterog enea do tumor e a necessidade de uma tratamento personalizado. A avalia c~ao pr evia da sensibilidade do tumor a quimioterapia e especialmente importante e justi c avel em pacientes com elevado risco de apresentar resist^encia ao tratamento. Neste projecto, este risco e avaliado atrav es da an alise da express~ao de marcadores moleculares tais como o CD147, previamente associado a mau progn ostico e resist^encia a cisplatina. O principal objectivo deste projecto era estabelecer um modelo directo de carcinoma urotelial invasivo da bexiga humano atrav es de xenotransplante em ratinhos imunode cientes, caracterizar o modelo e avaliar a sua viabilidade como plataforma para o estudo da sensibilidade e resist^ encia dos tumores a quimioterapia. Um dos 9 fragmentos transplantados cresceu como implante prim ario nos ratinhos, tendo sido transferido com sucesso para novos animais, onde desenvolveu tumor em 2 dos 3 animais transplantados. A an alise histol ogica e immuno-histoqu mica (CD147, p53, p63, ki-67 e CK20) do xenotransplante, mostrou haver preserva c~ao da morfologia e fen otipo do tumor prim ario, pelo menos durante o estabelecimento do xenotransplante. Estes resultados preliminares suportam o valor deste modelo para ensaios com f armacos, por em, s~ao necess arios estudos adicionais para validar o modelo e determinar o per l dos pacientes que podem bene- ciar desta abordagem.
Radical cystectomy is a standard treatment for invasive bladder cancer, however, approximately half of the patients have disease recurrence after surgery and require systemic chemotherapy. Signi cant variations in the natural history and responses to treatment of patients with invasive bladder cancer are seen between tumors with identical features, re ecting the heterogeneity of the constituent tumor cells and the necessity of a personalized management approach. The assessment of tumor sensitivity to chemotherapeutic drugs is especially important and justi able for patients with higher risk of showing drug resistance. In this project this risk was evaluated through the expression of molecular markers, such as CD147, that have been associated with poor outcome and cisplatin resistance. With this project we aimed to establish an urothelial cancer xenograft model in nude mice from a sample of invasive urothelial carcinoma, characterize it, and assess the feasibility of this model for chemotherapy sensitivity and resistance testing. 1 of 9 specimens has grown as primary implant in nude mice and the xenograft generated was successfully transfered to other mice with a take rate of 2 in 3. Histologic and immunohistochemical (CD147,p53, p63, ki-67 and CK20) analysis showed that xenografts retain the morphology and phenotype of the original tumor, at least during xenograft establishment. These preliminary results supports the value of this model for drug testing, however future studies are required to validate the model and determine the pro le of the patients that may bene t for this approach.
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Passini, Vanessa. ""Unsex Me Here...:" Looking at Gender in Nude Performance." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1794.
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"Unsex Me Here…" is an examination of our bodies, what they mean in terms of gender and power, and why they mean what they do. Plucked from Lady Macbeth’s infamous soliloquy, the title suggests the stripping away of something essential that transforms. Sex is not the right word, but gender is. Often, these two are mistaken and interchanged. Myths that support our social structure exist at the intersection of sex and gender. In this production, I collaborated with Pete Guither of the Living Canvas to challenge notions of gender in different textual mediums (via the written text of Shakespeare’s "Macbeth" and the text of the body itself) ultimately moving towards a space in which greater body understanding and acceptance exists. Our goal was a theatrical event that was both artistically beautiful and transformational not only for the artists involved in the process of making the piece but the audience as well.
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Messias, da Silva Menezes Junior Manoel. "Mapeando CSP em UML-RT." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/1723.
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Previous issue date: 2008A integração de métodos formais com notações semi-formais visuais é uma tendência em engenharia de software. Métodos formais apresentam uma semântica precisa e permitem verificação de propriedades. No entanto, não são considerados intuitivos. Por outro lado, notações semi-formais visuais, como UML, são facilmente integradas no processo de desenvolvimento de software. Assim, métodos formais e semi-formais visuais são complementares. CSP e UML-RT são, respectivamente, exemplos de notação formal e diagramática usados para especificar e projetar sistemas concorrentes e distribuídos. CSP é um método formal no qual processos representam unidades comportamentais que se comunicam através de canais de comunicação, utilizando passagem de mensagem. UML-RT é uma extensão conservativa de UML na qual cápsulas são unidades comportamentais que se comunicam através de portas de comunicação. Portas realizam protocolos os quais especificam os sinais que podem ser enviados e recebidos através de uma porta, e a ordem na qual os sinais podem ser comunicados. Em um trabalho anterior, Ferreira apresentou um conjunto de regras que sistematizam o mapeamento de CSP para UML-RT, mas uma prova formal deste mapeamento não foi apresentada. Assim, para garantir consistência no desenvolvimento de sistemas concorrentes e distribuídos utilizando este mapeamento, a prova formal do mesmo é indispensável, uma vez que não faz sentido o esforço dedicado à especificação do sistema em CSP e a verificação de propriedades e refinamentos, se uma ou mais regras de mapeamento estiverem incorretas. No entanto, UMLRT não possui uma semântica formal padrão. Entre outras propostas de semântica formal, Ramos propõe uma semântica para UML-RT utilizando OhCircus (uma combinação de CSP e Z com características adicionais de orientação a objetos) como modelo semântico. Neste trabalho, é proposta uma variação da semântica de Ramos para UML-RT usando CSP como modelo semântico. Com base nesta semântica, é apresentada a prova do mapeamento de CSP para UML-RT, considerando o modelo de falhas e divergências de CSP. Assim, este trabalho consolida a integração de CSP e UML-RT proposta por Ferreira, no desenvolvimento de sistemas críticos, concorrentes e distribuídos. Um resultado interessante foi observar que, estritamente, as regras propostas por Ferreira não preservam a semântica de CSP, essencialmente com relação a aspectos de terminação dos processos
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Teixeira, Ramos Rodrigo. "Desenvolvimento rigoroso com Uml-Rt." Universidade Federal de Pernambuco, 2005. https://repositorio.ufpe.br/handle/123456789/2806.
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Previous issue date: 2005Petróleo Brasileiro S.A.
Como outros métodos visuais orientados a objetos, UML tem influenciado tremendamente a prática de modelagem na engenharia de software com ricos mecanismos de estruturação. Porém, apesar de suas vantagens e adoção em larga escala, na prática, a falta de uma semântica formal tem dificultado o desenvolvimento rigoroso baseado em modelos de aplicações não triviais (aplicações que por sua natureza necessitam de ênfase na especificação e na verificação de seus componentes). A razão para isto é que transformações de modelos podem não preservar a semântica e, como conseqüência, o comportamento do modelo. Este problema é ainda mais sério em transformações que envolvem diferentes visões do modelo. Limitações similares podem ser encontradas durante o desenvolvimento com UML-RT. Esta linguagem é uma extensão conservativa de UML que provê a noção de objetos ativos (objetos com um comportamento próprio, independente do fluxo de execução do restante do sistema) para descrever aplicações concorrentes e distribuídas. Neste tipo de desenvolvimento, transformações devem lidar simultaneamente com as diferentes visões estáticas e dinâmicas do modelo, representadas por seus diagramas e propriedades. Por estes motivos, este trabalho propõe uma semântica para UML-RT, mapeando suas construções em OhCircus, uma linguagem formal, orientada a objetos, que combina CSP e Z, e que suporta o cálculo de refinamentos de Morgan. A partir desta semântica, bem como das noções e leis de refinamentos de OhCircus, é possível propor leis de transformação de modelos passíveis de demonstração e que preservam o comportamento do sistema. Estas leis de transformação são propostas em duas categorias: a primeira delas é um conjunto abrangente de leis básicas que expressam pequenas mudanças nas principais visões do modelo, como a declaração ou remoção de elementos do modelo; já a segunda representa leis de transformação de maior granularidade, derivadas a partir da composição de leis básicas, como a decomposição de uma cápsulas em cápsulas operando em paralelo. Tais transformações derivadas podem ser vistas como refatoramentos (refactorings) corretos sobre o modelo, facilmente aplicáveis durante um processo de desenvolvimento rigoroso, sem que o desenvolvedor tenha conhecimento do formalismo que o suporta. Finalmente, a abrangência deste conjunto de leis é discutida particularmente através dos principais passos de uma estratégia de redução de modelos UML-RT a um modelo UML estendido com um único objeto ativo, responsável por todas as interações com o ambiente e por conservar o comportamento dinâmico do sistema modelado. Este modelo UML estendido pode ser visto como uma forma normal, e, portanto, nossa estratégia pode ser vista como uma contribuição para uma estratégia mais global de completude capturada por redução a esta forma normal
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Kelling, Jeffrey, and Guido Juckeland. "Profiling of RT-PICLS Code." Helmholtz-Zentrum Dresden-Rossendorf, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-224404.
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It was observed, that the RT-PICLS code ran by FWKT on the hypnos cluster was producing an unusual amount of system load, according to Ganglia metrics. Since this may point to an IO-problem in the code, this code was analyzed more closely.
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Molina, Jennifer, Carolina Moreno, and Maricel Saso. "Aplicación de la RT 22." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Económicas, 2012. http://bdigital.uncu.edu.ar/5182.
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A través de este trabajo se pretende analizar y sintetizar la Resolución Técnica nº 22 de la Federación Argentina de Consejos Profesionales de Ciencias Económicas y estudiar específicamente la existencia de un mercado activo para el activo biológico (uva) que luego se transforma en producto agropecuario.Fil: Molina, Jennifer. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.
Fil: Moreno, Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.
Fil: Saso, Maricel. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.
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Hallett, Christopher H. "The Roman nude : heroic portrait statuary 200 BC-AD 300 /." Oxford : Oxford university press, 2005. http://catalogue.bnf.fr/ark:/12148/cb40979695t.
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McEwin, Florence Rebecca. "American women artists and the female nude image (1969-1983)." Thesis, North Texas State University, 1986. http://catalog.hathitrust.org/api/volumes/oclc/23638110.html.
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Thesis (Ph. D.)--North Texas State University, 1986.Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 367-404).
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Winthrop, Emily. "Allegories of the Modern: The Female Nude in Art Nouveau." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4203.
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Modernism is a plurality, not a singular concept. This project explores examples of Art Nouveau nudes to describe the particular expressions of the modern through varied and complicated allegorical bodies. The female nude as a nexus for ideals of gender, art, and beauty, is informed by and constructs the understanding of these ideals within society. Art Nouveau thus employed the nude to represent complex manifestations of modernity. Three diverse cases provide the subjects of each chapter. All explore modernism through objects and interiors, in public and private environments, and each connects the decorative arts with accounts of European modernism in the late nineteenth and early twentieth century. The modernist movement, in these decades, is still predominantly understood through painting.
This project draws its case studies from Paris, Glasgow, and Vienna, each a distinct cultural arena during the 1890s and 1900s: the sculptural furniture of François Rupert Carabin (1862-1932); the metalwork of Margaret Macdonald (1865-1933) and her sister Frances Macdonald (1873-1921); and the graphic motifs of Ver Sacrum, created by the artists of the first Vienna Secession (1897-1905). In conception and expression, these nudes articulated the diverse representational practices of different modernisms. They each embody drastically different histories, aesthetics, and social expressions. Their varied modernisms expose the prominent nationalism of Art Nouveau. Examination of these three very different cases expands and complicates current understandings of the nude, allegory, and the modern.
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Radić, Xavier. "Queer reflections on Baron Wilhelm von Gloeden a creative reconsideration of pose, gaze and technique : this exegesis [thesis] is submitted to the Auckland University of Technology in partial fulfilment of the degree of Master of Art and Design in the year 2004 /." Full thesis. Abstract, 2004.
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Angioi, Duprez Karine. "La souris nude : un modèle d'études expérimentales des xénogreffes de tissus humains." Nancy 1, 1993. http://www.theses.fr/1993NAN19430.
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Bezerra, Juliana de Melo. "Mapeamento UML-RT para p-calculus." Instituto Tecnológico de Aeronáutica, 2006. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=365.
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A UML (Unified Modeling Language) é uma linguagem de modelagem para especificar, construir e documentar artefatos de sistemas de software. A UML-RT, usada pela ferramenta Rational Rose RealTime (RoseRT), é uma extensão da UML que permite a modelagem de sistemas de tempo real distribuídos e guiados por evento. A UML-RT não possui semântica formal, logo não é possível realizar verificação formal do modelo. O presente trabalho propõe o mapeamento dos elementos de comunicação da UML-RT para a álgebra de processos p-calculus, a fim de prover semântica formal à UML-RT. Com objetivo de automatizar o mapeamento, foi desenvolvido um protótipo de tradutor que captura o modelo UML-RT especificado na ferramenta RoseRT e determina suas definições p-calculus. As definições p-calculus geradas utilizam a sintaxe da gramática do HAL-JACK, que é uma ferramenta integrada para verificação e análise de sistemas expressos em p-calculus, assim as definições p-calculus podem ser submetidas ao HAL-JACK para verificação formal de propriedades. Este trabalho detalha o mapeamento UML-RT para p-calculus, descreve o protótipo desenvolvido e apresenta alguns exemplos do mapeamento do modelo UML-RT para definições p-calculus.
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Kerestedjian, Jean-Jacques. "Traitement de l'infection expérimentale à "Rhodococcus equi" chez la souris nude." Paris 5, 1992. http://www.theses.fr/1992PA05P111.
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Gavigan, Thomas. "VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/133.
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Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only to further understand the disease but also to provide a method with which to test novel therapeutics. This study quantified the volumetric growth of a human medulloblastoma (VC312) in the athymic nude mouse cerebellum using Gd- enhanced T1-weighed MRI scans. Additionally, a medulloblastoma flank tumor model was used to explore the in vivo effect of the oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway. In the orthotopic intracerebellar tumor model, perifosine significantly increased the survival of treated mice while qualitatively reducing leptomeningeal dissemination. In the flank model, perifosine effectively suppressed the volumetric growth, decreased activation of the AKT pathway and reduced cellular proliferation in treated mice.
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Ferreira, Karin Correa Scheffer. "Detecção do vírus da raiva em órgãos de morcegos do gênero Artibeus (Leach, 1821) por meio de RT-PCR, Hemi-Nested RT-PCR e Real Time RT-PCR." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-19102012-132944/.
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Este estudo teve como objetivo detectar a presença do vírus da raiva em diferentes órgãos de morcegos do gênero Artibeus empregando as técnicas moleculares como RT-PCR, hnRT-PCR e Real Time RT-PCR. De aproximadamente 4000 espécimes de morcegos recebidas no Instituto Pasteur para o diagnóstico da raiva, foram selecionados 30 morcegos do gênero Artibeus, com resultados positivos para raiva pelas técnicas tradicionais de IFD e inoculação em células N2A utilizando suspensões feitas a partir do SNC. Para as técnicas moleculares, foram retirados glândulas salivares, bexigas urinárias, rins, pulmões e conteúdos fecais e ainda foram lavadas as calotas cranianas dos espécimes. Os órgãos e conteúdos fecais foram diluídos a 1:10 (P/V) e as bexigas urinárias a 1:20 (P/V). As suspensões foram inoculadas em células N2A para o isolamento viral. Foi realizada a extração do RNA total usando o TRIzol®, foram realizadas a transcrição reversa seguida da PCR e hnRT-PCR com utilização de primers específicos para o gene codificante da proteína N. A partir do produto da transcrição reversa foi realizada a técnica de Real Time RT-PCR, utilizando primers e sonda específicos para variante antigênica 3. Das 30 suspensões de lavado cerebral, 28 (93,33%) resultaram positivos, na inoculação em cultura de células, seguido de glândulas salivares (36,67%), bexigas (16,67%) e conteúdos fecais (3,33%). Os resultados encontrados da sensibilidade nas técnicas de RT-PCR, hnRT-PCR e Real Time RT-PCR foram 56,25%, 82,57% e 82,19% quando avaliadas as 180 amostras analisadas. A comparação das técnicas de hnRT-PCR e Real Time RT-PCR feita pelo teste exato de Fisher quanto a proporção de positivos detectados mostrou que para o lavado cerebral, órgãos e conteúdos fecais a proporção foi igual (P>0,05). Em relação à positividade os resultados encontrados nas técnicas de hnRT-PCR e Real Time RT-PCR foram 100% em lavado cerebral; 90% e 93,33% em glândulas salivares; 83,33% e 90% em bexigas; 80% e 93,33% em rins; 76,67% e 50% em pulmões e 43,33% em ambas as técnicas em conteúdos fecais. Esses resultados sugerem que tanto as técnicas de hnRT-PCR como Real Time RT-PCR podem ser utilizadas como métodos complementares para o diagnóstico da raiva e são sensíveis o bastante para o uso em estudos de patogênese. A técnica de Real Time RT-PCR realizada neste estudo se mostrou eficiente em detectar o RABV em diferentes órgãos e tecidos extraneurais com a vantagem de ser uma técnica mais rápida e sensível.This study was aimed to detect the presence of rabies virus in different organs of the genus Artibeus bats using molecular techniques such as RT-PCR, hnRT-PCR, and the Real Time RT-PCR. From about 4,000 specimens of bats received for rabies diagnosis at the Pasteur Institute, 30 bats of the genus Artibeus were then selected. The selected bats presented positive results by the traditional DFA and N2A-cells inoculation test using brain tissue suspensions. Samples of salivary glands, urinary bladders, kidneys, lungs, and fecal contents and washings of the skulls were collected for the molecular techniques testing. The organs and the fecal contents were diluted at 1:10 (w/v) and the urinary bladder, at 1:20 (w/v) and these suspensions were inoculated into N2A cells for viral isolation. The extraction of the total RNA was performed by using TRIzol® and followed by the reverse transcription and the PCR and the hnRT-PCR were performed by using specific primers for the gene encoding the protein N. The product obtained by the reverse transcription technique was submitted to the Real Time RT-PCR technique, using primers and probe specific for antigenic variant 3 of the rabies virus. Of the 30 suspensions of the brain washings, 28 (93.33%) were positive in N2A cell culture inoculation, followed by the suspensions of the salivary glands (36.67%), bladders (16.67%) and fecal contents (3.33%). For the 180 samples evaluated, the results of sensitivity found for the RT-PCR, hnRT-PCR and Real Time RT-PCR techniques were 56.25%, 82.57%, and 82.19%, respectively. A comparison of hnRT-PCR and Real Time RT-PCR techniques performed by Fisher\'s exact test showed that the proportion of positives detected by the brain washings, organs and of the fecal content was non-significant (P> 0.05). Regarding the results found in hnRT-PCR and Real Time RT-PCR techniques, 100% positives were in brain washing, 90% and 93.33% in salivary glands, 83.33% and 90% in bladders, 80% and 93.33% in kidneys, 76.67% and 50% in lungs and 43.33% for both techniques on fecal contents. These results suggest that both hnRT-PCR and Real-Time PCR techniques can be used as complementary methods for the diagnosis of rabies and are sensitive enough for use in pathogenesis studies. The Real Time RT-PCR technique performed in this study proved to be faster and more sensitive and effective in detecting RABV in different organs and extra neural tissues of bats.
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Stumpf-Condry, Claudia. "The renaissance of Antinous (1500-1550)." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269970.
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McKee, David Wesley. "n-Dimensional prediction of RT-SOA QoS." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18658/.
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Service-Orientation has long provided an effective mechanism to integrate heterogeneous systems in a loosely coupled fashion as services. However, with the emergence of Internet of Things (IoT) there is a growing need to facilitate the integration of real-time services executing in non-controlled, non-real-time, environments such as the Cloud. As such there has been a drive in recent years to develop mechanisms for deriving reliable Quality of Service (QoS) definitions based on the observed performance of services, specifically in order to facilitate a Real-Time Quality of Service (RT-QoS) definition. Due to the overriding challenge in achieving this is the lack of control over the hosting Cloud system many approaches either look at alternative methods that ignore the underlying infrastructure or assume some level of control over interference such as the provision of a Real-Time Operating System (RTOS). There is therefore a major research challenge to find methods that facilitate RT-QoS in environments that do not provide the level of control over interference that is traditionally required for real-time systems. This thesis presents a comprehensive review and analysis of existing QoS and RT-QoS techniques. The techniques are classified into seven categories and the most significant approaches are tested for their ability to provide QoS definitions that are not susceptible to dynamic changing levels of interference. This work then proposes a new n-dimensional framework that models the relationship between resource utilisation, resource availability on host servers, and the response-times of services. The framework is combined with real-time schedulability tests to dynamically provide guarantees on response-times for ranges of resource availabilities and identifies when those conditions are no longer suitable. The proposed framework is compared against the existing techniques using simulation and then evaluated in the domain of Cloud computing where the approach demonstrates an average overallocation of 12%, and provides alerts across 94% of QoS violations within the first 14% of execution progress.
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Taylor, Gene. "RT TELEMETRY NETWORK UPGRADE BASED ON ETHERNET." International Foundation for Telemetering, 1991. http://hdl.handle.net/10150/612902.
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International Telemetering Conference Proceedings / November 04-07, 1991 / Riviera Hotel and Convention Center, Las Vegas, NevadaNew techniques for using Ethernet in real time systems are applicable to the typical requirements of high performance Telemetry installations. Most TM installations around the world today are currently implemented using specialized, high speed, point-to-point data paths which have reached their limits in performance. By using Ethernet in real time as a “Data Highway” path, system performance is optimized, and the effective life of a Telemetry system can be significantly extended. Additionally, by integrating a Local Area Network into the system, further advantages are realized. New graphics display hardware and software may be used to provide virtually an “offthe-shelf”, and very cost-effective major system upgrade. Meanwhile, little modification to the host processor hardware or software system is required. This paper examines these premises, and discusses several examples of major Telemetry systems which have made this upgrade.
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McCusker, Nicole Catherine. "Performance, Art and the Female Nude at Dr Sketchy's Anti-Art School." Thesis, University of Canterbury. Social and Political Sciences, 2012. http://hdl.handle.net/10092/7656.
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My thesis examines the event of Dr Sketchy's Anti-Art School, which has branches in over 120 cities worldwide. Dr Sketchy's combines the format of a life drawing class with burlesque performance, creating an event that focuses on both the performance and the creation of art by the attendees. Dr Sketchy's was begun in New York in 2005 by its creator Molly Crabapple, now an internationally recognized artist and popular alternative celebrity. I focus my study on the Christchurch branch of Dr Sketchy's Anti-Art School, founded in June 2010 by Audrey Baldwin, a performance artist and Fine Arts graduate of the University of Canterbury.
In my thesis I discuss the way Dr Sketchy's Anti-Art School combines and compromises between the life drawing format and the burlesque performance, despite the differences and seeming incompatibilities between these two forms. I investigate Dr Sketchy's as a contemporary cultural performance which combines and to some degree inverts established genres of performance. I give a detailed history of burlesque performance and of life drawing within art education to allow a comprehensive comparison of the two traditions, particularly the way each has conceptualized the nude female body. I argue that the combination of the two forms allows Dr Sketchy's Anti-Art School to transgress the traditional boundaries of each format and introduce influences that would otherwise endanger the status of life drawing and burlesque performance within their respective contexts. I also argue that the nude within Dr Sketchy's Anti-Art School transgresses the traditional conception of the nude within life drawing by using burlesque as an acceptable reference for the transgressive elements of the show.
The arguments put forward in this thesis are the product of extensive participant observation, interviews and literature reviews on the relevant art and performance traditions.
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Chapman, C. J. "The study of T cell tolerance induction in thymus grafted nude mice." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383979.
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Laidlaw, Ian James. "Xenograft studies of normal human breast epithelium transplanted to athymic nude mice." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321307.
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Demarchez, Michel. "La Régénération de la peau humaine adulte transplantée sur la souris "nude"." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37604379f.
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Tolley, Rebecca. "Review of Curve: The Female Nude Now, by David Ebony & others." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/5723.
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Cambray, i. Amenós Maria. "Radio-quimioteràpia (RT-QT) preoperatòria en el càncer de recte. Estudi prospectiu amb grup control de RT-QT postoperatòria." Doctoral thesis, Universitat de Barcelona, 2006. http://hdl.handle.net/10803/1091.
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INTRODUCCIÓ: La radioteràpia preoperatòria, en el càncer de recte, ha mostrat la seva eficàcia millorant el control local de la malaltia i la supervivència. També s'ha demostrat que la RT administrada en el preoperatori és més eficaç que la que se administra després de la cirurgia. Por tot això, a principis de l'any 1996, vàrem posar en marxa, un estudi prospectiu de RT-QT preoperatòria. Analitzarem els resultats terapèutics aconseguit i els compararem amb els obtinguts en pacients tractats segons el nostre estàndard de RT-QT postoperatòria.PACIENTS I MÈTODES: El tractament consistia en administrar radioteràpia, 45 Gy, a 1.8 Gy por sessió, concurrent amb quimioteràpia, 5 fluorouracilo en infusió continua durant tota la radioteràpia; la intervenció quirúrgica es programava a las 6-8 setmanes de finalitzar el tractament preoperatori i després de la cirurgia s'administrava 5 fluorouracil en bolus i leucovorin x 4 cicles.
Els pacients que arribaven ja operats al nostre centre amb intenció radical i estadificats com T3-T4, N0 o qualsevol T amb N+, entraven en l'esquema de tractament postoperatori: 45 Gy a 1.8 Gy por sessió, concurrent amb quimioteràpia, basada en el 5 Fluorouracil.
Entre els anys 1996 i 2000 varen entrar en l'estudi de radio-quimioteràpia preoperatòria 94 pacients. D'aquests, 15 presentaven malaltia irresecable i, entre els pacients amb malaltia resecable, el 77% d'ells eren estadificats com un T3-4,N+. En el mateix període de temps es tractaren 237 pacients intervinguts de càncer de recte amb RT-QT postoperatòria. En 18 pacients la cirurgia fou incompleta.
RESULTATS: Vàrem observar una taxa de remissions completes al tractament neoadjuvant de 17% y una taxa de respostes globals del 68%. La taxa de preservació d'esfínter anal ha estat del 38.5%. La supervivència global als 5 anys ha estat del 67% y la supervivència lliure de malaltia del 70%. La taxa de recidiva local ha estat del 9% (recidiva local exclusiva del 3.3%) y la sistèmica del 26%. Respecte la toxicitat tardana per la RT varen observar 5 pacients amb enteritis ràdica grau 3. Cap pacient es va haver d'intervenir por aquest problema.
Supervivència global segons la resposta al tractament: del 87% en els pacients en els que s'observà una remissió completa de la tumoració, del 75% en los que hi hagué una remissió parcial, del 48% si els que s'observà una estabilització de la malaltia i en els pacients que progressaren, la supervivència mitjana fou de 0.84 anys. p<0.05.
En el grup control: la supervivència global ha estat del 66.5% i la lliure de malaltia del 65.4% y no hi ha diferències estadístiques amb el grup de l'estudi.
La taxa de recidiva local ha estat del 7.3% (1.8% de recidiva local aïllada), amb una taxa de recidiva sistèmica del 33.3%. Les diferències respecte el grup de l'estudi tampoc han estat estadísticament significatives (p=0.54).
Respecte la toxicitat tardana, en forma d'enteritis ràdica, 13 pacients presentaren una enteritis grau 3 (5.5%) i 10 (4.2%) es varen haver d'intervenir per aquesta causa (enteritis grau 4). Les diferències respecte el grup de l'estudi són estadísticament significatives, presentant menys toxicitat quan la radioteràpia s'ha administrat preoperatoriament (p=0.022).
CONCLUSIONS: Es recomana el tractament preoperatori en el càncer de recte localment avançat ja que produeix un alt índex de respostes al tractament, cosa que permet cirurgies preservadores de l'esfínter anal en una tercera part dels pacients amb tumors rectals baixos; també, amb el tractament preoperatori, hi ha una clara disminució de la toxicitat tardana. Per altra part, la resposta al tractament preoperatori selecciona un grup de pacients amb millor pronòstic.
"PREOPERATIVE RADIOCHEMOTHERAPY (RT-CT) IN CANCER OF THE RECTUM. PROSPECTIVE STUDY WITH POSTOPERATIVE RT-CT GROUP CONTROL".
INTRODUCTION: Between 1996 and 2000 the Department of Surgery of Hospital Universitario de Bellvitge and Institut Català d'Oncologia carried out a non randomized prospective study of preoperative radiochemotherapy in locally advanced tumours of the rectum. Herein we expound our results.
On the other hand, in the same interval of time, patients already intervened for locally advanced cancer of the rectum were received and on whom postoperative radiochemotherapy was carried out according to our standard protocol. We compare the results obtained in both series.
MATERIAL AND METHODS: The preoperative RT-CT group includes 94 patients, diagnosed with adenocarcinoma of the rectum T3-T4, any N, MO. They were treated with radiotherapy concurrent with chemotherapy. The surgical intervention was programmed 6 - 8 weeks from finalizing the preoperative treatment and after surgery chemotherapy was administered once again.
The 237 patients that arrived at our centre already intervened and staged as T3 - T4 and/or N+, MO received postoperative RT - CT.
RESULTS: In the preoperative treatment group we observe a rate of complete and overall remissions to RT - CT of 17% and 68% respectively. The anal sphincter was preserved in 38.5 % of patients with low rectal tumours. The overall survival and disease free survival were different at 5 years, with statistical significance according to the response obtained with preoperative treatment, being better in those patients that responded. When we compare the two groups studied, out of the pre and postoperative RT - CT, we do not observe any difference with respect to survival or local control. As regards late toxicity, there were indeed differences, presenting less toxicity when radiotherapy was administered preoperatively (p=0.022).
CONCLUSIONS: Preoperative treatment is recommended in locally advanced cancer of the rectum as it produces a high index of responses to the treatment, allowing preservative surgery of the anal sphincter in one third of the patients with low rectal tumours; also with preoperative treatment there is a clear decrease of late toxicity. On the other hand the response to preoperative treatment selects a group of patients with a better prognosis.
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Birch, Hannah L. "A study of the figure in intaglio." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1318608.
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This project chronicles my explorations of the human figure in intaglio and relief printmaking and in the medium of artists' books. I had very little experience in the field of printmaking prior to my acceptance into the Masters program at Ball State University. I found intaglio, or etching into a metal plate, stimulating and exciting because there are very few limitations in terms of what I can do with this medium. I received a Bachelors of Fine Arts in drawing from SUNY Fredonia. Creating artwork in the printmaking medium has allowed my drawing skills to continue to grow and provided a variety of new technical possibilities. I choose to work with the figure because it is an important subject for an artist to study in order to learn to draw. Since all humans share the same basic structure, it is something that everyone should relate to. It is also something that translates into every possible medium, from cave drawings to fashion design. Many of the artists I have studied, such as Albrecht Durer, and Francisco Goya, worked with the figure in printmaking. Their work provided inspiration while I pursued my own work in this field.Department of Art
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Rosol, Thomas John. "Investigations on the pathogenesis and treatment of humoral hypercalcemia of malignancy using a canine hypercalcemic adenocarcinoma propagated in nude mice /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487323583621294.
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Miranda, Jurandir Tomaz de. "Influência do enxerto de pele humana irradiada na regeneração tecidual de camundongos nude." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-15092016-152304/.
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Nas últimas décadas tem aumentado o interesse pelos enxertos de pele humana radioesterilizadas, para aplicação principalmente em queimaduras extensas e profundas. Isto se deve ao fato destes enxertos apresentarem rápida aderência e menor potencial antigênico, em comparação com os demais tratamentos utilizados. A proposta deste estudo foi avaliar a histoarquitetura do enxerto de pele humana irradiada com doses de 25 kGy, 50 kGy e não irradiada, durante o processo de reparação tecidual, em camundongos Nude submetidos a enxertia de pele na região dorsal. Três grupos de animais receberam enxertos de pele humana irradiada (25 kGy e 50 kGy) e não irradiada e foram eutanasiados no 3º, 7º e 21º dia após a realização da cirurgia. Após os procedimentos histológicos de rotina, as amostras de tecido foram coradas com hematoxilina e eosina (HE) para a quantificação de queratinócitos, fibroblastos, células de defesa e vasos sanguíneos e a reação de imunofluorescência (IF) foi realizada para a determinação da expressão de colágeno do tipo I humano e do colágeno dos tipos I e III de camundongo. A quantificação, tanto das células quanto dos tipos de colágeno foi realizada por análise de imagem, utilizando o programa Image-Pro PLus 6.0. Os resultados histológicos demostraram que a pele humana irradiação, quando enxertada, influencia o aumento do número de células no local de cicatrização ao longo do tempo, principalmente na dose de 25 kGy, além de proporcionar uma melhor dispersão destas células. No 21º dia, os três grupos de animais com enxertia de pele humana tiveram parte do enxerto incorporado no processo de cicatrização. O grupo não irradiado apresentou maior incorporação do enxerto (43%), porém menor produção de colágeno do tipo III de camundongo (22%). Já os grupos com enxertia de pele irradiada apresentaram menor incorporação do enxerto (6 e 15%), mas com maior produção de colágeno do tipo III de camundongo (35% e 28%, para 25 kGy e 50 kGy, respectivamente). Com este estudo pôde-se concluir que o grupo irradiado a 25 kGy, apresenta maior proliferação celular e formação de vasos,além de melhor remodelamento da região de cicatrização.Over the last few years it has increased the interest in the human skin grafts radio sterilized for application mainly in extensive and deep burns. Because these grafts quickly grip and present antigenic lower potential, compared with other treatments used. The purpose of this study was to evaluate the histoarchitecture of human skin grafts irradiated with doses 25 kGy, 50 kGy and non-irradiated during the pepair tissue process in nude mice submitted by skin grafting in the dorsal region. Three groups of animals received irradiated human skin grafts (25 kGy and 50 kGy) and non-irradiated and were euthanized on the 3rd, 7th and 21th day after the surgery. Indeed, routine histologic procedures, tissue samples were stained with hematoxylin and eosin (HE) for quantification of keratinocytes, fibroblasts, immune cells and blood vessels and immunofluorescence (IF) was performed to determine the expression human collagen type I and collagen type I and III mouse. Therefore, quantification of both the cells and the collagen types was performed by image analysis using Image-Pro Plus 6.0 software. Histologic results demonstrated at a dose of 25 kGy that human skin irradiation when grafted influences the increase in the number of cells in wound site over time and it provides better dispersion of these cells. In addition, on the 21st day, three groups of animals with human skin graft were embedded part of the graft in the healing process. On the other hand, the group not irradiated showed greater incorporation of the graft (43 %), but less production of collagen type III mouse (22 %). Since the groups irradiated skin graft showed lower graft incorporation (6 and 15%), but with greater production of collagen type III mice (35 % and 28 % to 25 kGy and 50 kGy, respectively). In conclusion, this study presented that the group irradiated to 25 kGy and it has a higher cell proliferation and vessel formation, and better remodeling of the healing area.
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MIRANDA, JURANDIR T. de. "Influência do enxerto de pele humana irradiada na regeneração tecidual de camundongos nude." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26827.
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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-11T17:07:10Z
No. of bitstreams: 0Made available in DSpace on 2016-11-11T17:07:10Z (GMT). No. of bitstreams: 0
Nas últimas décadas tem aumentado o interesse pelos enxertos de pele humana radioesterilizadas, para aplicação principalmente em queimaduras extensas e profundas. Isto se deve ao fato destes enxertos apresentarem rápida aderência e menor potencial antigênico, em comparação com os demais tratamentos utilizados. A proposta deste estudo foi avaliar a histoarquitetura do enxerto de pele humana irradiada com doses de 25 kGy, 50 kGy e não irradiada, durante o processo de reparação tecidual, em camundongos Nude submetidos a enxertia de pele na região dorsal. Três grupos de animais receberam enxertos de pele humana irradiada (25 kGy e 50 kGy) e não irradiada e foram eutanasiados no 3º, 7º e 21º dia após a realização da cirurgia. Após os procedimentos histológicos de rotina, as amostras de tecido foram coradas com hematoxilina e eosina (HE) para a quantificação de queratinócitos, fibroblastos, células de defesa e vasos sanguíneos e a reação de imunofluorescência (IF) foi realizada para a determinação da expressão de colágeno do tipo I humano e do colágeno dos tipos I e III de camundongo. A quantificação, tanto das células quanto dos tipos de colágeno foi realizada por análise de imagem, utilizando o programa Image-Pro PLus 6.0. Os resultados histológicos demostraram que a pele humana irradiação, quando enxertada, influencia o aumento do número de células no local de cicatrização ao longo do tempo, principalmente na dose de 25 kGy, além de proporcionar uma melhor dispersão destas células. No 21º dia, os três grupos de animais com enxertia de pele humana tiveram parte do enxerto incorporado no processo de cicatrização. O grupo não irradiado apresentou maior incorporação do enxerto (43%), porém menor produção de colágeno do tipo III de camundongo (22%). Já os grupos com enxertia de pele irradiada apresentaram menor incorporação do enxerto (6 e 15%), mas com maior produção de colágeno do tipo III de camundongo (35% e 28%, para 25 kGy e 50 kGy, respectivamente). Com este estudo pôde-se concluir que o grupo irradiado a 25 kGy, apresenta maior proliferação celular e formação de vasos,além de melhor remodelamento da região de cicatrização.
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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KRUCZYNSKI, ANNA. "Caracterisation, par analyse morphonucleaire, de cancers pulmonaires humains greffes chez la souris nude." Toulouse 3, 1991. http://www.theses.fr/1991TOU30018.
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Une analyse multiparametrique morphonucleaire a permis de quantifier, au cours des passages en serie, l'evolution biologique de tumeurs pulmonaires humaines xenogreffees, ce qui n'etait pas possible par l'analyse histologique conventionnelle. La technique de la ponction a l'aiguille fine, adaptee aux tumeurs xenogreffees, a permis de suivre, in situ, pendant le traitement, l'efficacite therapeutique d'un poison des microtubules (navelbine) et d'un derive des cyclophosphazenes (f35)
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Gartner, Maria F. R. Moutinho. "The growth, metastases and hormonal sensitivities of human melanomas in the nude mouse." Doctoral thesis, University of Cape Town, 1986. http://hdl.handle.net/11427/26286.
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Guthrie, Elizabeth. "The Male, Nude, Celebrity Body: Daniel Radcliffe in Peter Shaffer's Equus." Bowling Green State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1282529866.
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Ip, Wing Cheung. "Shaw in blue, women in nude : Li Han-Hsiang's fengyue films in 1970s." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/872.
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Cook, Marcia. "Detection of Renibacterium salmoninarum by mRNA RT-PCR." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/MQ65481.pdf.
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Dahlin, Henrik. "Tidsserieanalys av aktiv norovirus-infektion med RT-qPCR." Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-20077.
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Norovirus som orsakar vinterkräksjukan är en av de vanligaste vintersjukdomarna i Sverige. Sjukdomstiden varar generellt i en till tre dagar med symptomen kräkning och/eller diarré. Till den totala sjukdomsbilden världen över gällande akut gastroenterit, bidrar norovirus med 18 %. Trots att sjukdomen är mycket vanlig är kunskapen om norovirusets förfarande till stor del okänd.Syftet med studien var att göra en tidsserieanalys, även så kallad One-Step Growth analys, av koncentrationen minus-RNA i celler som infekterats med olika koncentrationer av murint norovirus (MNV). För att detektera minus-RNA användes RT-qPCR med SYBR Green. Målet var att se om startkoncentrationerna av virus vid någon tidpunkt korrelerar med mängden minus-RNA i cellerna. Efter 4 och 8 timmar fanns ett exponentiellt samband mellan den initiala viruskoncentrationen och minus-RNA-uttrycket i cellerna. Koncentrationen minus-RNA i de infekterade cellerna ökade mellan de undersökta tiderna 4, 8 och 24 timmar. Vidare visade resultaten att det krävs 4 timmar för att minus-RNA skulle vara kvantifierbar vid en högre infektionskoncentration av viruspartiklar, medan det krävs 24 timmar för den lägre infektionskoncentrationen av viruspartiklar.Norovirus causes winter vomiting disease and is one of the commonest cause of winter illness in Sweden. The disease period generally lasts one to three days with symptoms like vomiting and/or diarrhea. To the disease burden of acute gastroenteritis worldwide, norovirus contributes with 18 %. Even though the illness is very common, the knowledge about norovirus is poor and largely unknown.The purpose of the study was to do a time series analysis, a so-called One-Step Growth analysis, of the minus-RNA concentration in cells infected with different concentrations of murine norovirus (MNV). For the detection of minus-RNA RT-qPCR was used with SYBR Green. The goal was to correlate start concentration of virus at any time with the amount of minus-RNA in the cells. At 4 and 8 hours there was an exponential connection by the initial virus concentration and minus-RNA development in the cells. The concentration of minus-RNA in the infected cells increased between 4, 8 and 24 hours. Further, the results can be interpreted as requiring 4 hours for the higher concentrations to become quantifiable, while requiring 24 hours for the lower concentrations to become quantifiable.
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Charpentier, Jellimann Stéphanie Duprez Adrien. "Développement morphologique et fonctionnel de la thyroïde fœtale humaine greffée chez la souris nude." [S.l.] : [s.n.], 2002. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2002_CHARPENTIER_JELLIMAN_STEPHANIE.pdf.
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Lozniewski, Alain. "Etude de l'infection à Helicobacter pylori et de la pénétration de l'amoxicilline dans des estomacs d'embryons humains greffés chez des souris Nude." Nancy 1, 1999. http://www.theses.fr/1999NAN19910.
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Différents modèles sont utilisés pour étudier, in vitro ou chez l'animal, la physiopathologie de l'infection gastrique à Helicobacter pylori ainsi que la pénétration intragastrique des antibiotiques utilisés dans le traitement d'éradication de cette bactérie. L'extrapolation à l'homme des résultats obtenus avec ces modèles hétérologues reste cependant difficile. Nous avons mis au point un nouveau modèle pour l'étude de l'infection gastrique à H. Pylori en utilisant des estomacs embryonnaires humains greffés chez la souris «nude». Après 80 jours de greffe, ces organes, qui présentent un épithélium bien différencié, ont été inoculés avec une souche récemment isolée (H. Pylori LB1) ou une souche de référence (H. Pylori ATCC 43504 ou H. Pylori ATCC 49504). Après un suivi de 12 semaines, seul H. Pylori LB1 a permis d'obtenir une colonisation persistante de la muqueuse antrale. Ce microorganisme a également été visualisé dans le cytoplasme de cellules de l'épithélium antral ou fundique. Nous avons ensuite comparé la pénétration de l'amoxicilline, administrée par voie intrapéritonéale, dans la muqueuse gastrique superficielle de greffons infectés (H. Pylori LB1) ou non. Pour toutes les souris, les concentrations sériques étaient, jusqu'à 3 heures après l'injection, similaires à celles observées chez l'homme après ingestion de 1 g d'amoxicilline. Les concentrations tissulaires étaient significativement plus élevées en cas d'infection. Ce modèle devrait permettre d'étudier les interactions entre H. Pylori et la muqueuse gastrique humaine et la pénétration de xénobiotiques dans la muqueuse infectéeDifferent in vitro or animal models have been used to investigate the pathogenesis of Helicobacter pylori infection and the gastric penetration of antibiotics used to eradicate this microorganism. However, extrapolation to humans of results obtained with these heterologous models remains difficult. We have developed a new model for the study of H. Pylori infection that uses human embryonic stomachs engrafted in «nude» mice. At 80 days after implantation, these organs, which exhibited a well differentiated epithelium, were inoculated with a freshly isolated H. Pylori isolated strain (H. Pylori LB1) or with a reference strain (H. Pylori ATCC 43504 or H. Pylori ATCC 49504). After 12-week examination, only H. Pylori LB1 persistently colonized the antral mucosa. Intracytoplasmic location of this microorganism was also obseNed in the antrum or the fundus. Then, we have compared the penetration of amoxicillin, after intraperitoneal administration, in the gastric mucosa of infected (H. Pylori LB1) or uninfected grafts. Serum concentrations were similar to those obtained in humans after oral administration of 1 g of amoxicillin. Tissular concentrations were significantly higher in infected grafts. Thus, this model should allow to study the interaction between H. Pylori and human gastric mucosa, and the penetration of xenobiotics in the infected mucosa
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Cunha, Mariana Sequetin. "Validação e uso de transcrição reversa seguida da reação em cadeia pela polimerase em tempo real (RT-qPCR) para a vigilância e diagnóstico de flavivírus transmitidos por mosquitos circulantes no Brasil." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-16102018-113026/.
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Os flavivírus são considerados uma séria ameaça à saúde pública em diversas partes do mundo, pois muitos são agentes altamente patogênicos a seres humanos e animais, tais como os vírus da febre amarela, vírus do Oeste do Nilo, vírus da encefalite japonesa e vírus da dengue, capazes de causar encefalites ou febres hemorrágicas em seus hospedeiros. Muitos deles têm avançado a diferentes regiões geográficas onde sua circulação não havia sido detectada previamente, causando novos surtos. O diagnóstico clínico destas infecções é, muitas vezes, difícil, devido ao grande número de sintomas apresentados, que podem se confundir com outras enfermidades de diferentes causas etiológicas. Os principais métodos diretos utilizados atualmente no Brasil para detecção destes vírus são a inoculação intracerebral em camundongos neonatos, inoculação em culturas de células e RTPCR específica. O presente trabalho tem como objetivos avaliar a sensibilidade e validar a detecção dos vírus pertencentes ao gênero Flavivirus circulantes no Brasil por meio de uma reação single de RT-PCR em tempo real e implementá-la, tanto na rotina diagnóstica de casos com suspeita de arbovirose como na pesquisa de amostras de campo para monitoramento viral. Amostras dos flavivírus padrões da Febre Amarela, Bussuquara, Iguape, Ilheus, Encefalite de Saint Louis, Cacipacore e Zika foram quantificados por titulação em unidades formadoras de placa (UFP) ou TCID50 para se avaliar os limites de detecção para cada um deles por RT-qPCR que detecta o gênero Flavivirus. Os limites encontrados variaram de 0,01 UFP, para o vírus Ilheus, a 1 UFP, para os vírus da Febre Amarela e Iguape, e 1x101,6 TCID50/100µL para o vírus Bussuquara. Além disso, o presente trabalho foi capaz de identificar, após sequenciamento de cDNA gerado, os vírus Zika, isolado de um paciente febril, e os vírus Ilheus e Iguape, isolados a partir de diferentes espécies de Culicídeos, após uma única reação de RT-qPCR, e um possível novo flavivírus específico de insetos, isolado de mosquitos Aedes coletados em Guapiaçu, São Paulo. Não houve sinal de amplificação para os Alphavirus Mayaro e Chikungunya. O presente protocolo mostrou-se com alta sensibilidade e especificidade, podendo dessa forma ser utilizado para o diagnóstico diferencial dos diferentes flavivírus que ocorrem no Brasil, bem como para estudos de monitoramento viral em animais sentinelas e vetores, colaborando dessa forma com a saúde pública. Pode-se, ainda, detectar possíveis novos vírus específicos de artrópodesFlaviviruses are considered a serious threat to public health in many parts of the world, as many are highly pathogenic to humans and animals, such as Yellow Fever virus, West Nile virus, Japanese encephalitis virus and dengue virus, which are capable of causing encephalitis or hemorrhagic fever in their hosts. Many of them have spread to different geographic regions where their circulation had not been detected previously, causing new outbreaks. Diagnosis of these infections is often difficult, due to the large number of symptoms presented, which can be confused with other diseases of different etiological causes. The main direct methods currently used in Brazil for detecting these viruses are intracerebral inoculation in neonatal mice, inoculation in cell cultures and specific RT-PCR. The present work aims to evaluate the sensitivity and validate the detection of viruses belonging to the genus Flavivirus circulating in Brazil through a single real-time RT-PCR reaction and to implement it, both in the diagnostic routine of cases with arbovirus suspicions and in field samples for viral monitoring. Samples of the standard flaviviruses Yellow Fever, Bussuquara, Iguape, Ilheus, Saint Louis Encephalitis, Cacipacore and Zika were quantified by titration by plaque forming units (UFP) or TCID50 to evaluate the detection limits for each of them by RT- qPCR that detects genus Flavivirus. The limits found ranged from 0.01 PFU for Ilheus virus to 1 PFU for Yellow Fever and Iguape viruses and 1x101.6 TCID50 / 100L for the Bussuquara virus. In addition, the present work was able to identify, after cDNA sequencing Zika virus, isolated from a febrile patient, and both Ilheus and Iguape viruses, isolated from different species of Culicidae, and a possible new insect-specific flavivirus, isolated from Aedes mosquitoes collected in Guapiaçu, São Paulo. The Alphaviruses Mayaro and Chikungunya were not amplified. The present protocol shoed high sensitivity and specificity, and therefore it may may be used for the differential diagnosis of the different flaviviruses that occur in Brazil, as well as for viral monitoring studies in sentinel animals and vectors, thus collaborating with public health. It is also possible to detect new flavivirus that are arthopode-specific.
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Concia, Massimo. "Fluorescence labeled PEI-based gene delivery systems for near infrared imaging in nude mice." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-113095.
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Sugimura, Isamu, Takashi Adachi-Yamada, Yoshimi Nishi, and Yasuyoshi Nishida. "A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development." Blackwell Synergy, 2000. http://hdl.handle.net/2237/7296.
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Al, Saati Talal. "Production d'anticorps monoclonaux à l'aide des splénocytes de souris "nude" porteuses de tumeurs humaines." Toulouse 3, 1990. http://www.theses.fr/1990TOU30077.
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Des anticorps monoclonaux identifiant de nouveaux antigenes associes aux tumeurs ont ete produits en utilisant les splenocytes de souris nude athymiques greffees avec des tumeurs humaines. Il apparait que la stimulation par des lipopolysaccharides bacteriens ou la reconstitution de l'immunite cellulaire apres la xenogreffe augmente le nombre et la diversite des anticorps obtenus. Les anticorps ainsi produits sont differents de ceux obtenus avec les souris balb/c normales. Plusieurs anticorps ont ete obtenus. L'anticorps bnh. 9 reconnait un antigene saccharidique exprime par les cellules endotheliales des vaisseaux et les lymphomes anaplasiques a grandes cellules (50% des cas). Parmi les autres anticorps, deux, hne. 51 et hnc. 142, sont diriges contre un nouvel antigene d'activation (cdw70). A l'aide d'une lignee lymphomateuse etablie dans le laboratoire, quatre anticorps anti-b lymphocytes (dbb. 42 et dba. 44: splenocytes de balc/c normales; dna. 7 et dnd. 53: splenocytes de souris nude reconstituees) detectent des antigenes resistants a la fixation des tissus. Ces anticorps offrent donc de nouvelles possibilites dans le phenotypage des lymphomes malins sur materiels fixes et inclus en paraffine. Cette etude suggere que l'utilisation des splenocytes de souris nude reconstituees greffees avec de nouvelles lignees tumorales est l'approche la plus prometteuse dans la production de nouveaux anticorps monoclonaux