Journal articles: 'Nutricosmetic'

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Dini, Irene, and Sonia Laneri. "The New Challenge of Green Cosmetics: Natural Food Ingredients for Cosmetic Formulations." Molecules 26, no. 13 (June 26, 2021): 3921. http://dx.doi.org/10.3390/molecules26133921.

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Nowadays, much attention is paid to issues such as ecology and sustainability. Many consumers choose “green cosmetics”, which are environmentally friendly creams, makeup, and beauty products, hoping that they are not harmful to health and reduce pollution. Moreover, the repeated mini-lock downs during the COVID-19 pandemic have fueled the awareness that body beauty is linked to well-being, both external and internal. As a result, consumer preferences for makeup have declined, while those for skincare products have increased. Nutricosmetics, which combines the benefits derived from food supplementation with the advantages of cosmetic treatments to improve the beauty of our body, respond to the new market demands. Food chemistry and cosmetic chemistry come together to promote both inside and outside well-being. A nutricosmetic optimizes the intake of nutritional microelements to meet the needs of the skin and skin appendages, improving their conditions and delaying aging, thus helping to protect the skin from the aging action of environmental factors. Numerous studies in the literature show a significant correlation between the adequate intake of these supplements, improved skin quality (both aesthetic and histological), and the acceleration of wound-healing. This review revised the main foods and bioactive molecules used in nutricosmetic formulations, their cosmetic effects, and the analytical techniques that allow the dosage of the active ingredients in the food.

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Shahrin, Ruzanna, Farzana Quoquab, Jihad Mohammad, and Rossilah Jamil. "Factors affecting consumers' pro-environmental behaviour in nutricosmetics consumption: the role of perceived environmental responsibility as a mediator." Journal of Asia Business Studies 14, no. 5 (April 13, 2020): 671–89. http://dx.doi.org/10.1108/jabs-02-2019-0035.

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Purpose This study aims to examine the direct effect of compensatory health beliefs (CHBs), environmental self-identity and perceived environmental responsibility (PER) towards consumers' pro-environmental behaviour (PEB). Moreover, this study also investigates the mediating role of PER. Design/methodology/approach Data were collected from nutricosmetics consumers in Malaysia. A questionnaire survey was carried out in three major shopping complexes in Klang Valley areas, which generated 448 completed usable responses. The partial least square technique (SmartPLS, version 3) was used to analyse the data and to test the study hypotheses. Findings The results revealed that CHBs, environmental self-identity and environmental perceived responsibility positively affect consumers’ PEB in nutricosmetics consumption. Additionally, data supported the mediating role of PER in the relationship between CHB, environmental self-identity and PEB. Practical implications It is expected that the study findings will provide significant insights to help marketers and policymakers about consumers’ nutricosmetic products consumption. It will help the marketers to plan for effective marketing strategies to produce environmentally friendly products and to serve the green consumer segment effectively. Moreover, companies attempting to launch new nutricosmetics brands may find the results helpful in understanding PEB. Originality/value This study is among the pioneers to examine consumers’ PEB of nutricosmetics products. Moreover, there is a dearth of studies that have investigated the PEB of consumers in regard to the CHBs, environmental self-identity and PER towards nutricosmetics consumption. Additionally, this study examines the mediating role of PER between “CHBs and PEB” and “environmental self-identity and PEB”, which are yet to examine in the past literature in the field.

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Taofiq, Oludemi, Maria Filomena Barreiro, and Isabel C. F. R. Ferreira. "The Role of Bioactive Compounds and other Metabolites from Mushrooms against Skin Disorders- A Systematic Review Assessing their Cosmeceutical and Nutricosmetic Outcomes." Current Medicinal Chemistry 27, no. 41 (December 8, 2020): 6926–65. http://dx.doi.org/10.2174/0929867327666200402100157.

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Bioactive compounds derived from mushrooms have been shown to present promising potential as cosmeceutical or nutricosmetic ingredients. Scientific data reviewed herein showed that extracts prepared from medicinal and edible mushrooms and their individual metabolites presented antiinflammatory, antioxidant, photoprotective, antimicrobial, anti-tyrosinase, anti-elastase, and anticollagenase activities. These metabolites can be utilised as ingredients to suppress the severity of Inflammatory Skin Diseases, offer photoprotection to the skin, and correct Hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps from the fruiting bodies to the final product: extraction optimization, estimation of the efficacy and safety claims, the use of micro and nanocarriers to allow for controlled release and the pros and cons associated with the use of extracts vs individual compounds. This systematic review highlights that mushrooms contain diverse biomolecules that can be sustainably used in the development of nutricosmetic and cosmeceutical formulations. Reports regarding stability, compatibility, and safety assessment, but also toxicological studies are still needed to be considered. Furthermore, some of the constraints and limitations hindering the development of this type of ingredients still require long-term studies to achieve major breakthroughs.

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Laneri, S., RM Di Lorenzo, A. Bernardi, A. Sacchi, and I. Dini. "Aloe barbadensis: A Plant of Nutricosmetic Interest." Natural Product Communications 15, no. 7 (July 2020): 1934578X2093274. http://dx.doi.org/10.1177/1934578x20932744.

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Aloe barbadensis Miller (Aloe Vera Linne) products have long been employed in health foods and for medical purposes. It has anti-inflammatory, antifungal, antioxidant properties, which indicates excellent potential in antiaging cosmetic and skin protection products. The objective of this study is to evaluate the antiaging efficacy of dermocosmetic formulations containing A. barbadensis extract on young and mature skin using biophysical and skin imaging techniques. Twenty healthy adult volunteers participated in the study, aged between 20 and 65. The cream formulation, with 10% (w/w) of A. barbadensis extract, and placebo, were applied to the face of the volunteers. The effects were evaluated in terms of skin hydration and barrier effect by the measurement of transepidermal water loss (TEWL), derma firmness, and elasticity. The formulation containing A. barbadensis extract significantly improves water contained in the stratum corneum, firmness, elasticity of the skin, and decreased TEWL.

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Pyo, Young-Hee, and Yoo-Jeong Jin. "Monascus-mediated fermentation improves the nutricosmetic potentials of soybeans." Food Science and Biotechnology 25, no. 3 (June 2016): 883–91. http://dx.doi.org/10.1007/s10068-016-0145-0.

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Gromkowska-Kępka, Krystyna Joanna, Renata Markiewicz-Żukowska, Patryk Nowakowski, Sylwia Katarzyna Naliwajko, Justyna Moskwa, Anna Puścion-Jakubik, Joanna Bielecka, et al. "Chemical Composition and Protective Effect of Young Barley (Hordeum vulgare L.) Dietary Supplements Extracts on UV-Treated Human Skin Fibroblasts in In Vitro Studies." Antioxidants 10, no. 9 (August 31, 2021): 1402. http://dx.doi.org/10.3390/antiox10091402.

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Young barley seems to be a promising material for use as nutricosmetic due to the presence of many biologically active compounds. The aim of this study was to evaluate the effect of Hordeum vulgare L. extracts on human skin fibroblasts exposed to ultraviolet radiation B (UVB) radiation. Analysis of the chemical composition showed a predominance of 9,12,15-octadecatrienoic acid. The quality assessment showed that young barley preparations have high total polyphenolic content (TPC) and favourable total antioxidant status (TAS). They also contain antioxidant elements such as zinc, copper, and selenium. Furthermore, the analyzed products were found to be safe in terms of toxic elements (lead, cadmium and mercury) and lack of cytotoxic effect of young barley extracts on cells. In vitro bioactivity assays showed that young barley extract increased the survival rate and accelerated the migration of fibroblasts in research models with UVB radiation. The application of both extracts caused an increase in DNA biosynthesis, and in the number of cells arrested in S phase. Moreover, an inhibitory effect of the tested extracts on the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) was observed. The results indicate that young barley extracts, due to protective as well as restorative effect, could potentially be used in the production of nutricosmetics and skin care products.

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Dini, Irene. "Contribution of Nanoscience Research in Antioxidants Delivery Used in Nutricosmetic Sector." Antioxidants 11, no. 3 (March 16, 2022): 563. http://dx.doi.org/10.3390/antiox11030563.

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Nanoscience applications in the food and cosmetic industry offer many potential benefits for consumers and society. Nanotechnologies permit the manipulation of matter at the nanoscale level, resulting in new properties and characteristics useful in food and cosmetic production, processing, packaging, and storage. Nanotechnology protects sensitive bioactive compounds, improves their bioavailability and water solubility, guarantees their release at a site of action, avoids contact with other constituents, and masks unpleasant taste. Biopolymeric nanoparticles, nanofibers, nanoemulsions, nanocapsules, and colloids are delivery systems used to produce food supplements and cosmetics. There are no barriers to nanoscience applications in food supplements and cosmetic industries, although the toxicity of nano-sized delivery systems is not clear. The physicochemical and toxicological characterization of nanoscale delivery systems used by the nutricosmeceutic industry is reviewed in this work.

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Dinica, Rodica Mihaela, Cristina Sandu, Andreea Veronica Dediu Botezatu, Anna Cazanevscaia Busuioc, Fanica Balanescu, Maria Daniela Ionica Mihaila, Caterina Nela Dumitru, Bianca Furdui, and Alina Viorica Iancu. "Allantoin from Valuable Romanian Animal and Plant Sources with Promising Anti-Inflammatory Activity as a Nutricosmetic Ingredient." Sustainability 13, no. 18 (September 11, 2021): 10170. http://dx.doi.org/10.3390/su131810170.

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Helix aspersa (HA), Helix pomatia (HP) and Symphytum officinale are common organisms in Romania’s biosphere, widely known for their allantoin content and their therapeutic properties. Herein, the allantoin was separated and quantified from the aqueous extracts of Romanian comfrey root and the secretions of HA and HP snails. This study also focused on determining the antioxidant and anti-inflammatory activities of these Romanian allantoin-rich samples. The plant extracts were obtained through two methods: ultrasonic extraction and enzymatic ultrasonic extraction. A microplate method was used for the quantitative determination of allantoin content. The antioxidant activity was measured by using the DPPH radical scavenging method. The antioxidant capacity of the samples was studied in order to observe the type of interactions generated by the chemical complex present in their composition. High concentrations of allantoin were obtained by enzymatic ultrasonic extraction method (EUE—102 ± 0.74 μg/mL), and also in the water-soluble fraction of the snail secretion (FS1—22.051 μg/mL). The antioxidant screening suggests that Symphytum officinale and snail mucus extracts could be used as promising natural substitutes for synthetic antioxidants in products used for therapeutic purposes. The evaluation of anti-inflammatory activity was also investigated, allantoin-rich samples showing a promising action (FS1—81.87 ± 2.34%). In future, the inclusion of allantoin-rich extracts in various novel pharmaceutical forms for new therapeutic applications could be achieved. The study will continue with the formulation of a nutricosmetic product with snail mucus and Symphytum officinale extract as principal bioactive ingredients.

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Meléndez-Martínez, Antonio J., Carla M. Stinco, and Paula Mapelli-Brahm. "Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene." Nutrients 11, no. 5 (May 16, 2019): 1093. http://dx.doi.org/10.3390/nu11051093.

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In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless UV radiation (UVR)-absorbing dietary carotenoids phytoene and phytofluene, which are attracting increased interest in food science and technology, nutrition, health and cosmetics. These compounds are major dietary carotenoids, readily bioavailable, and have been shown to be involved in several health-promoting actions, as pinpointed in recent reviews. The growing evidence that these unique UVR-absorbing carotenoids with distinctive structures, properties (light absorption, susceptibility to oxidation, rigidity, tendency to aggregation, or even fluorescence, in the case of phytofluene) and activities can be beneficial in these contexts is highlighted. Additionally, the recommendation that the levels of these carotenoids are considered in properly assessing skin carotenoid status is made.

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Sadgrove, Nicholas John, and Monique S. J. Simmonds. "Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids." FASEB BioAdvances 3, no. 8 (June 6, 2021): 601–10. http://dx.doi.org/10.1096/fba.2021-00022.

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Rashid, Albayati, and Dodou. "Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid." Cosmetics 6, no. 4 (October 1, 2019): 59. http://dx.doi.org/10.3390/cosmetics6040059.

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Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and optimized the method of crosslinking for formulating novel HA hydrogel films. We used Pentaerythritol Tetra-acrylate (PT) as the cross-linking agent over a range of pH values and used different cross-linking methods (Ultraviolet (UV) radiation, microwaving, and oven heating). The efficacy of the cross-linking reaction was evaluated using swelling studies and Fourier transform infrared (FTIR) spectroscopy for the characterization of the xerogel HA-PT film formulations. We found that HA-PT cross-linked hydrogels are produced under alkaline conditions (pH 11) but not under neutral or acidic conditions. Cross-linked HA-PT xerogel films using UV-irradiation showed excessive swelling indicative of inadequate cross-linking. The oven and microwaving methods produced HA-PT films with high cross-linking density. FTIR data suggest formation of ester bond between the carbonyl of the HA and hydroxyl group of the PT acrylate group. Overall, the oven method was considered better and easier than UV-radiation/microwave methods because it is safer, user-friendly and eco-friendly, and can process larger batches.

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Bukhari, Syed Nasir Abbas, Nur Liyana Roswandi, Muhammad Waqas, Haroon Habib, Fahad Hussain, Shahzeb Khan, Muhammad Sohail, Nor Amlizan Ramli, Hnin Ei Thu, and Zahid Hussain. "Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects." International Journal of Biological Macromolecules 120 (December 2018): 1682–95. http://dx.doi.org/10.1016/j.ijbiomac.2018.09.188.

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Kang, Min, Silvia Yumnam, and Sun Kim. "Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis." International Journal of Molecular Sciences 19, no. 11 (November 11, 2018): 3551. http://dx.doi.org/10.3390/ijms19113551.

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Collagen peptide (CP) has beneficial effects on functions of the skin, such as skin barrier function and skin elasticity, in vivo. However, there are few studies investigating the mechanism underlying the potential effects of CP in skin epidermal moisturization after ultraviolet B (UVB) irradiation. In this study, we examined whether orally-administered CP affects the loss of skin hydration induced by UVB irradiation in hairless mice. SKH-1 hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. The potential effects of CP were evaluated by measuring the transepidermal water loss (TEWL), skin hydration, wrinkle formation, and hyaluronic acid expression in the dorsal mice skin. We found that oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue. The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP. In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging. Therefore, we suggest that CP can be used as a nutricosmetic ingredient with potential effects on UVB-induced skin dehydration and moisture loss in addition to wrinkle formation.

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Roncea, Florentina, Radu Cazacincu, Horaţiu Mireşan, and Romulus Adrian Roșca. "Nutricosmetics. Updates and perspectives." Farmacist.ro 6, no. 191 (2019): 24. http://dx.doi.org/10.26416/farm.191.6.2019.2688.

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Dini, Irene, and Sonia Laneri. "Nutricosmetics: A brief overview." Phytotherapy Research 33, no. 12 (September 3, 2019): 3054–63. http://dx.doi.org/10.1002/ptr.6494.

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Quoquab, Farzana, Jihad Mohammad, and Ruzanna Shahrin. "Pro-environmental behavior in nutricosmetics product purchase context." International Journal of Pharmaceutical and Healthcare Marketing 14, no. 2 (March 14, 2020): 217–50. http://dx.doi.org/10.1108/ijphm-04-2019-0033.

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Purpose Though the concern over pro-environmental behavior is growing, there is a lack of a valid scale to measure pro-environmental behavior in nutricosmetics context. Nutricosmetics products are believed to boost health and fitness and thus gained worldwide popularity. Many consumers in recent days are purchasing nutricosmetics products because of its positive impact toward human health and less harm toward the environment. However, to date, there is no valid instrument to measure this construct. To fill this gap in the existing literature, this study aims to develop a valid and reliable scale to measure pro-environmental behavior in nutricosmetics purchase (PEB-NP). Design/methodology/approach To develop and validate the PEB-NP scale, a sequential process is followed which includes item generation, item selection, item purification and item validation. Relevant literature was reviewed and qualitative interviews were carried out to generate the items. Next, experts’ opinion was sought to select the items. Two studies were conducted (N = 150, N = 448) to explore the factor structure and to validate the scale. Exploratory factor analysis (EFA) was used to purify the scale, whereas confirmatory factor analysis (CFA) using SmartPLS (version 3) was used to validate the scale. Findings Based on EFA output, 14 items were retained which were then validated using CFA. The results revealed that, PEB-NP is a hierarchical multi-dimensional construct. The dimensions are “environmental aesthetics,” “conservation behavior (reduce and recycle)” and “health consciousness.” The findings from CFA confirmed the EFA results and established that pro-environmental behavior is a third-order factor model in which conservation dimension is consisted of two sub-dimensions, namely, “reduce” and “recycle” behavior. Practical implications The newly developed scale will enable the marketers and policymakers to segment their consumers based on this scale to better strategize the marketing efforts in fulfilling their needs. Not only this, the PEB-NP scale will benefit marketers in understanding the behavioral pattern and purchase preference of the pro-environmental consumers with regard to the nutricosmetics consumption. This research also provides suggestions for future researchers in the pro-environmental behavior and nutricosmetics fields. Originality/value This study is a pioneer study to develop and validate the PEB scale in the context of nutricosmetics purchase.

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Alharbi, Khlood Lafi, Jegadeesh Raman, and Hyun-Jae Shin. "Date Fruit and Seed in Nutricosmetics." Cosmetics 8, no. 3 (June 24, 2021): 59. http://dx.doi.org/10.3390/cosmetics8030059.

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Many recent studies in the field of cosmetics have focused on organically sourced substances. Products made from organic materials are safe, high quality, cruelty-free, and more effective than those made from synthetic materials. Many organic compounds are known to be physiologically active in humans and have an extended storage capacity and long-lasting environmental effects. Agro-industrial waste has recently increased substantially, and the disposal of date palm waste, often performed in primitive ways such as burning, is harmful to the environment. Fruit processing industries generate over 10% of the total date seed waste daily, which could be converted into useful food products. Date fruit and seed are rich in sugar, vitamins, fiber, minerals, and phenolic compounds with antioxidant and anti-inflammatory properties that significantly promote human and animal health. This waste is rich in bioactive compounds and essential oils used in many kinds of food, medicine, and cosmetics. Most active cosmetic ingredients come from natural sources such as fruit, fish, and dairy, and recent research shows that date extract and seed oil help to reduce melanin, eczema, acne, and dry patches, while increasing skin moisture and elasticity. This review details the bioactive compounds and nutraceutical properties of date fruit and seed, and their use as cosmetic ingredients.

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Heinrich, U. "Nutritives Anti-Aging." Aktuelle Dermatologie 43, no. 10 (October 2017): 427–30. http://dx.doi.org/10.1055/s-0043-112476.

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ZusammenfassungFür die Substanzklasse der Carotinoide konnte gezeigt werden, dass diese in lipophilen Systemen als Antioxidantien wirksam sind. In zahlreichen Studien wurde nachgewiesen, dass Carotinoide nicht nur Algen und Pflanzen vor intensiver Sonneneinstrahlung schützen, sondern auch beim Menschen von einer fotoprotektiven Wirkung ausgegangen werden kann. Um die Gesundheit von Haut und Haar zu erhalten, werden vermehrt sogenannte „Nutricosmetics“ angeboten. Hier stellt sich die Frage, ob unsere Ernährung tatsächlich alle notwendigen Mikronährstoffe enthält.Zahlreiche Studien zeigten, dass „Nutricosmetics“ zur Verbesserung einzelner Hautparameter wie Oberflächenstruktur, Hautdichte und -Elastizität führten. Weiterhin wurden Hydratation und Barrierefunktion der Haut positiv beeinflusst. Anti-Aging-Konzepte wurden bestätigt. Natürliche Carotinoide, häufig in Kombination mit Vitaminen und Mineralstoffen, führten zu einer Steigerung der Wirksamkeit, hier spielen synergistische Effekte offenbar eine Rolle. Auch andere Wirkstoffe wie Polyphenole, aus Kakao oder grünem Tee gewonnen, hatten positive Wirkungen auf die Hautparameter bei täglicher Einnahme als Drink.In den hier gezeigten Untersuchungen konnten nach 12-wöchiger Einnahme nachhaltige Wirkungen von „Nutricosmetics“ nachgewiesen werden. Somit kann eine, zumindest temporäre, Supplementierung von Nahrungsergänzungsmitteln zur Erhöhung des körpereigenen Lichtschutzes oder zur Verbesserung der Hautqualitäten empfohlen werden. Allerdings sollten Nahrungsergänzungsmittel nicht als Ausgleich einer ungesunden Ernährung verstanden werden.

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Anunciato, Talita Pizza, and Pedro Alves da Rocha Filho. "Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals." Journal of Cosmetic Dermatology 11, no. 1 (February 24, 2012): 51–54. http://dx.doi.org/10.1111/j.1473-2165.2011.00600.x.

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López-Hortas, Lucía, Noelia Flórez-Fernández, Maria D. Torres, Tania Ferreira-Anta, María P. Casas, Elena M. Balboa, Elena Falqué, and Herminia Domínguez. "Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics." Marine Drugs 19, no. 10 (September 29, 2021): 552. http://dx.doi.org/10.3390/md19100552.

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The interest in seaweeds for cosmetic, cosmeceutics, and nutricosmetics is increasing based on the demand for natural ingredients. Seaweeds offer advantages in relation to their renewable character, wide distribution, and the richness and versatility of their valuable bioactive compounds, which can be used as ingredients, as additives, and as active agents in the formulation of skin care products. Bioactive compounds, such as polyphenols, polysaccharides, proteins, peptides, amino acids, lipids, vitamins, and minerals, are responsible for the biological properties associated with seaweeds. Seaweed fractions can also offer technical features, such as thickening, gelling, emulsifying, texturizing, or moistening to develop cohesive matrices. Furthermore, the possibility of valorizing industrial waste streams and algal blooms makes them an attractive, low cost, raw and renewable material. This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.

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Alves, Ana, Emília Sousa, Anake Kijjoa, and Madalena Pinto. "Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics." Molecules 25, no. 11 (May 29, 2020): 2536. http://dx.doi.org/10.3390/molecules25112536.

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The cosmetic industry is among the fastest growing industries in the last decade. As the beauty concepts have been revolutionized, many terms have been coined to accompany the innovation of this industry, since the beauty products are not just confined to those that are applied to protect and enhance the appearance of the human body. Consequently, the terms such as cosmeceuticals and nutricosmetics have emerged to give a notion of the health benefits of the products that create the beauty from inside to outside. In the past years, natural products-based cosmeceuticals have gained a huge amount of attention not only from researchers but also from the public due to the general belief that they are harmless. Notably, in recent years, the demand for cosmeceuticals from the marine resources has been exponentially on the rise due to their unique chemical and biological properties that are not found in terrestrial resources. Therefore, the present review addresses the importance of marine-derived compounds, stressing new chemical entities with cosmeceutical potential from the marine natural resources and their mechanisms of action by which these compounds exert on the body functions as well as their related health benefits. Marine environments are the most important reservoir of biodiversity that provide biologically active substances whose potential is still to be discovered for application as pharmaceuticals, nutraceuticals, and cosmeceuticals. Marine organisms are not only an important renewable source of valuable bulk compounds used in cosmetic industry such as agar and carrageenan, which are used as gelling and thickening agents to increase the viscosity of cosmetic formulations, but also of small molecules such as ectoine (to promote skin hydration), trichodin A (to prevent product alteration caused by microbial contamination), and mytiloxanthin (as a coloring agent). Marine-derived molecules can also function as active ingredients, being the main compounds that determine the function of cosmeceuticals such as anti-tyrosinase (kojic acid), antiacne (sargafuran), whitening (chrysophanol), UV protection (scytonemin, mycosporine-like amino acids (MAAs)), antioxidants, and anti-wrinkle (astaxanthin and PUFAs).

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Taofiq, Oludemi, Ana M. González-Paramás, Anabela Martins, Maria Filomena Barreiro, and Isabel C. F. R. Ferreira. "Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review." Industrial Crops and Products 90 (November 2016): 38–48. http://dx.doi.org/10.1016/j.indcrop.2016.06.012.

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Royer, Mariana, Maria Prado, Martha Estrella García-Pérez, Papa Niokhor Diouf, and Tatjana Stevanovic. "Study of nutraceutical, nutricosmetics and cosmeceutical potentials of polyphenolic bark extracts from Canadian forest species." PharmaNutrition 1, no. 4 (October 2013): 158–67. http://dx.doi.org/10.1016/j.phanu.2013.05.001.

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Meléndez-Martínez, Antonio J. "Nutricosmetics: Vanity Can Help Increase the Consumption of Health-Promoting Foods in the Sustainability Era." ACS Food Science & Technology 2, no. 3 (February 16, 2022): 474–75. http://dx.doi.org/10.1021/acsfoodscitech.2c00049.

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Davinelli, Sergio, Juan Carlos Bertoglio, Ascanio Polimeni, and Giovanni Scapagnini. "Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage." Current Pharmaceutical Design 24, no. 2 (April 5, 2018): 99–105. http://dx.doi.org/10.2174/1381612823666171109102426.

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Background: Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin structure, function and appearance. Polyphenols, which are secondary plant metabolites, represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. The main objective is to provide an overview of the existing literature linking skin aging and the ability of polyphenols as regulatory elements able to maintain skin homeostasis. Methods: In this review, we discuss recent progress in understanding the molecular bases of skin aging, with specific emphasis on some well known and extensively studied polyphenols which have significant anti-aging influences and photoprotective effects. Results: Although no relevant clinical data exist and standard delivery systems have not been established, promising results have been obtained in many in vitro and animal models. A wide variety of polyphenols may minimize mechanisms underlying the functional manifestations of photoaging and chronological skin aging. Conclusion: Polyphenols exert their influence mostly through their antioxidant and anti-inflammatory effects, thereby abrogating collagen degradation and/or increasing procollagen synthesis.

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Meléndez-Martínez, Antonio J., Paula Mapelli-Brahm, and Carla M. Stinco. "The colourless carotenoids phytoene and phytofluene: From dietary sources to their usefulness for the functional foods and nutricosmetics industries." Journal of Food Composition and Analysis 67 (April 2018): 91–103. http://dx.doi.org/10.1016/j.jfca.2018.01.002.

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Jin, Young Hun, Ah Ran Jeon, and Jae-Hyung Mah. "Tyrosinase Inhibitory Activity of Soybeans Fermented with Bacillus subtilis Capable of Producing a Phenolic Glycoside, Arbutin." Antioxidants 9, no. 12 (December 18, 2020): 1301. http://dx.doi.org/10.3390/antiox9121301.

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The production of arbutin, an effective tyrosinase inhibitor as well as an outstanding antioxidant, by 691 Bacillus strains isolated from soybean-based foods was tested to enhance the tyrosinase inhibitory activity of soybeans via fermentation with the strains. Among the strains tested, the 5 strains capable of significantly producing arbutin were identified as B. subtilis via 16S rRNA sequencing. When soybeans were fermented with each of the selected strains, the arbutin content was highest on day 1 of fermentation and decreased thereafter. However, the tyrosinase inhibitory activity of the fermented soybeans continuously increased as fermentation progressed, whereas the activity of non-inoculated soybeans was consistently low. The results indicate that arbutin enhances the tyrosinase inhibitory activity of soybeans in the early period of fermentation, while other substances besides arbutin contribute to the activity in the later period. Consequently, soybeans fermented with arbutin-producing B. subtilis strains could be considered as a natural source of cosmeceuticals and nutricosmetics used in skin lightening and may be of interest in the food industry because they contain well-known and powerful antioxidants such as arbutin and other substances.

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Angilè, Federica, Laura Del Coco, Chiara Roberta Girelli, Lorena Basso, Lucia Rizzo, Stefano Piraino, Loredana Stabili, and Francesco Paolo Fanizzi. "1H NMR Metabolic Profile of Scyphomedusa Rhizostoma pulmo (Scyphozoa, Cnidaria) in Female Gonads and Somatic Tissues: Preliminary Results." Molecules 25, no. 4 (February 13, 2020): 806. http://dx.doi.org/10.3390/molecules25040806.

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The Mediterranean basin is one of the regions heavily affected by jellyfish bloom phenomena, mainly due to the presence of scyphozoans, such as Rhizostoma pulmo. The jellyfish have few natural predators, and their bodies represent an organic-rich substrate that can support rapid bacterial growth with great impact on the structure of marine food webs. In Asiatic countries, jellyfish are widely studied for their health benefits, but their nutritional and nutraceutical values still remain poorly characterized. In this study, the differences in the 1H NMR spectroscopy metabolic profiles of R. pulmo female gonads and body fractions (including umbrella and oral arms), in different sampling periods, were studied. For each body compartment both lipid and aqueous extracts were characterized and their 1H NMR metabolic profiles subjected to multivariate analysis. From a statistical analysis of the extracts, a higher contents of ω-3 polyunsaturated fatty acids (PUFAs), amino acid and osmolytes (homarine, betaine, taurine) with important roles in marine invertebrates were observed in female gonads, whereas umbrella and oral arms showed similar metabolic profiles. These results support a sustainable exploitation of the jellyfish for the extraction of bioactive compounds useful in nutraceutical, nutricosmetics, and functional food fields.

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Fernando, Ilekuttige Priyan Shanura, Mawalle Kankanamge Hasitha Madhawa Dias, Disanayaka Mudiyanselage Dinesh Madusanka, Eui Jeong Han, Min Ju Kim, You-Jin Jeon, Kyounghoon Lee, et al. "Human Keratinocyte UVB-Protective Effects of a Low Molecular Weight Fucoidan from Sargassum horneri Purified by Step Gradient Ethanol Precipitation." Antioxidants 9, no. 4 (April 21, 2020): 340. http://dx.doi.org/10.3390/antiox9040340.

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Ultraviolet B (UVB) radiation-induced oxidative skin cell damage is a major cause of photoaging. In the present study, a low molecular weight fucoidan fraction (SHC4) was obtained from Sargassum horneri by Celluclast-assisted extraction, followed by step gradient ethanol precipitation. The protective effect of SHC4 was investigated in human keratinocytes against UVB-induced oxidative stress. The purified fucoidan was characterized by Fourier-transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (NMR), agarose gel-based molecular weight analysis and monosaccharide composition analysis. SHC4 had a mean molecular weight of 60 kDa, with 37.43% fucose and 28.01 ± 0.50% sulfate content. The structure was mainly composed of α-L-Fucp-(1→4) linked fucose units. SHC4 treatment dose-dependently reduced intracellular reactive oxygen species (ROS) levels and increased the cell viability of UVB exposed HaCaT keratinocytes. Moreover, SHC4 dose-dependently inhibited UVB-induced apoptotic body formation, sub-G1 accumulation of cells and DNA damage. Inhibition of apoptosis was mediated via the mitochondria-mediated pathway, re-establishing the loss of mitochondrial membrane potential. The UVB protective effect of SHC4 was facilitated by enhancing intracellular antioxidant defense via nuclear factor erythroid 2–related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Further studies may promote the use of SHC4 as an active ingredient in cosmetics and nutricosmetics.

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Purcell-Meyerink, Diane, Michael A. Packer, Thomas T. Wheeler, and Maria Hayes. "Aquaculture Production of the Brown Seaweeds Laminaria digitata and Macrocystis pyrifera: Applications in Food and Pharmaceuticals." Molecules 26, no. 5 (February 28, 2021): 1306. http://dx.doi.org/10.3390/molecules26051306.

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Seaweeds have a long history of use as food, as flavouring agents, and find use in traditional folk medicine. Seaweed products range from food, feed, and dietary supplements to pharmaceuticals, and from bioenergy intermediates to materials. At present, 98% of the seaweed required by the seaweed industry is provided by five genera and only ten species. The two brown kelp seaweeds Laminaria digitata, a native Irish species, and Macrocystis pyrifera, a native New Zealand species, are not included in these eleven species, although they have been used as dietary supplements and as animal and fish feed. The properties associated with the polysaccharides and proteins from these two species have resulted in increased interest in them, enabling their use as functional foods. Improvements and optimisations in aquaculture methods and bioproduct extractions are essential to realise the commercial potential of these seaweeds. Recent advances in optimising these processes are outlined in this review, as well as potential future applications of L. digitata and, to a greater extent, M. pyrifera which, to date, has been predominately only wild-harvested. These include bio-refinery processing to produce ingredients for nutricosmetics, functional foods, cosmeceuticals, and bioplastics. Areas that currently limit the commercial potential of these two species are highlighted.

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Goyal, Anju, Aditya Sharma, Jasanpreet Kaur, Sapna Kumari, Madhukar Garg, Rakesh K. Sindhu, Md Habibur Rahman, et al. "Bioactive-Based Cosmeceuticals: An Update on Emerging Trends." Molecules 27, no. 3 (January 27, 2022): 828. http://dx.doi.org/10.3390/molecules27030828.

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Cosmetic-containing herbals are a cosmetic that has or is claimed to have medicinal properties, with bioactive ingredients purported to have medical benefits. There are no legal requirements to prove that these products live up to their claims. The name is a combination of “cosmetics” and “pharmaceuticals”. “Nutricosmetics” are related dietary supplements or food or beverage products with additives that are marketed as having medical benefits that affect appearance. Cosmetic-containing herbals are topical cosmetic–pharmaceutical hybrids intended to enhance the health and beauty of the skin. Cosmetic-containing herbals improve appearance by delivering essential nutrients to the skin. Several herbal products, such as cosmetic-containing herbals, are available. The present review highlights the use of natural products in cosmetic-containing herbals, as natural products have many curative effects as well as healing effects on skin and hair growth with minimal to no side effects. A brief description is given on such plants, their used parts, active ingredients, and the therapeutic properties associated with them. Mainly, the utilization of phytoconstituents as cosmetic-containing herbals in the care of skin and hair, such as dryness of skin, acne, eczema, inflammation of the skin, aging, hair growth, and dandruff, along with natural ingredients, such as for hair colorant, are explained in detail in the present review.

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Maia Campos, Patrícia Maria Berardo Gonçalves, Rodolfo Scarpino Barboza Franco, Letícia Kakuda, Gabriel Fernandes Cadioli, Gabriela Maria D’Angelo Costa, and Elodie Bouvret. "Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study." Molecules 26, no. 16 (August 12, 2021): 4880. http://dx.doi.org/10.3390/molecules26164880.

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Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral supplementation with hydrolyzed fish cartilage for the improvement of chronological and photoaging-induced skin changes. A total of 46 healthy females aged 45 to 59 years were enrolled and divided into two groups: G1—placebo and G2—oral treatment with hydrolyzed fish cartilage. Measurements of skin wrinkles, dermis echogenicity and thickness, and morphological and structural characteristics of the skin were performed in the nasolabial region of the face before and after a 90-day period of treatment using high-resolution imaging, ultrasound, and reflectance confocal microscopy image analyses. A significant reduction in wrinkles and an increase of dermis echogenicity were observed after a 90-day period of treatment with hydrolyzed fish cartilage compared to the placebo and baseline values. In addition, reflectance confocal microscopy (RCM) image analysis showed improved collagen morphology and reduced elastosis after treatment with hydrolyzed fish cartilage. The present study showed the clinical benefits for the skin obtained with oral supplementation with a low dose of collagen peptides from hydrolyzed fish cartilage.

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Meléndez-Martínez, Antonio J., Volker Böhm, Grethe Iren Andersen Borge, M. Pilar Cano, Martina Fikselová, Ruta Gruskiene, Vera Lavelli, et al. "Carotenoids: Considerations for Their Use in Functional Foods, Nutraceuticals, Nutricosmetics, Supplements, Botanicals, and Novel Foods in the Context of Sustainability, Circular Economy, and Climate Change." Annual Review of Food Science and Technology 12, no. 1 (March 25, 2021): 433–60. http://dx.doi.org/10.1146/annurev-food-062220-013218.

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Carotenoids are versatile isoprenoids that are important in food quality and health promotion. There is a need to establish recommended dietary intakes/nutritional reference values for carotenoids. Research on carotenoids in agro-food and health is being propelled by the two multidisciplinary international networks, the Ibero-American Network for the Study of Carotenoids as Functional Foods Ingredients (IBERCAROT; http://www.cyted.org ) and the European Network to Advance Carotenoid Research and Applications in Agro-Food and Health (EUROCAROTEN; http://www.eurocaroten.eu ). In this review, considerations for their safe and sustainable use in products mostly intended for health promotion are provided. Specifically, information about sources, intakes, and factors affecting bioavailability is summarized. Furthermore, their health-promoting actions and importance in public health in relation to the contribution of reducing the risk of diverse ailments are synthesized. Definitions and regulatory and safety information for carotenoid-containing products are provided. Lastly, recent trends in research in the context of sustainable healthy diets are summarized.

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NASER, WISAM. "THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW." International Journal of Applied Pharmaceutics, January 7, 2021, 10–18. http://dx.doi.org/10.22159/ijap.2021v13i1.39806.

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Nutricosmetics have emerged to indicate the health benefits of the products that create beauty from inside to outside. Nutricosmetic is the latest trend in the beauty industry. Cosmeceuticals are commonly used in skincare regimens to maintainhealthy skin and improve visible signs of aging. Natural products that target skin have gained great attention due to the general belief that they are harmless. A review of the biomedical literature was conducted using peer-reviewed journal articles toidentify laboratory, animal, and clinical studies that have evaluated recent breakthroughs in the biological properties and potential dermatologic uses of the different natural bioactive ingredients used in nutricosmetics and Cosmeceuticals. Bioactive ingredients used in Nutri-cosmeceutical products are derived from collagen, peptides, proteins, vitamins, carotenes, minerals, omega‐3 fatty acids and plant extracts. These ingredients have been shown to provide dermatologic benefits with potential applications for skin regeneration, photoprotection, wound healing, and more.The information provided by this article is valuable to get the picture of the latest trends. In addition, it might be helpful for clinicians and related manufacturing companies. Despite several developments in this field, extensive research is required for performing successful and precise clinical trials in the future. Further improvements would enable the researchers to develop new products in this field.

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NASER, WISAM. "THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW." International Journal of Applied Pharmaceutics, January 7, 2021, 10–18. http://dx.doi.org/10.22159/ijap.2021v13i1.39806.

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Nutricosmetics have emerged to indicate the health benefits of the products that create beauty from inside to outside. Nutricosmetic is the latest trend in the beauty industry. Cosmeceuticals are commonly used in skincare regimens to maintainhealthy skin and improve visible signs of aging. Natural products that target skin have gained great attention due to the general belief that they are harmless. A review of the biomedical literature was conducted using peer-reviewed journal articles toidentify laboratory, animal, and clinical studies that have evaluated recent breakthroughs in the biological properties and potential dermatologic uses of the different natural bioactive ingredients used in nutricosmetics and Cosmeceuticals. Bioactive ingredients used in Nutri-cosmeceutical products are derived from collagen, peptides, proteins, vitamins, carotenes, minerals, omega‐3 fatty acids and plant extracts. These ingredients have been shown to provide dermatologic benefits with potential applications for skin regeneration, photoprotection, wound healing, and more.The information provided by this article is valuable to get the picture of the latest trends. In addition, it might be helpful for clinicians and related manufacturing companies. Despite several developments in this field, extensive research is required for performing successful and precise clinical trials in the future. Further improvements would enable the researchers to develop new products in this field.

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Sriyab, Suwannee, Nachtharinee Laosirisathian, Chanun Punyoyai, Songyot Anuchapreeda, Singkome Tima, Sawitree Chiampanichayakul, and Wantida Chaiyana. "Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor." Scientific Reports 11, no. 1 (April 22, 2021). http://dx.doi.org/10.1038/s41598-021-88340-2.

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AbstractThis study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were determined by 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) and a ferric reducing antioxidant power assay. Matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibition were determined by in vitro enzyme reaction assay. The cytotoxicity was analyzed on peripheral blood mononuclear cellss. Findings revealed that drying temperature and drying duration had significant effects on the chemical composition and biological activity of A. officinalis extract. A. officinalis tips dried at 50 °C for 24 h contained the (significantly) highest flavonoid and rutin content. The most potent extract was from A. officinalis spears since it possessed the (significantly) highest MMP-1, elastase, and hyaluronidase inhibition rates of 83.4 ± 1.5%, 70.4 ± 4.1%, and 75.2 ± 1.0%, respectively. Interestingly, at the same concentration, the A. officinalis spear extract was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural MMP-1 inhibitors. The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients.

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Hernandez, David Fonseca, Eugenia Lugo Cervantes, Diego A. Luna-Vital, and Luis Mojica. "Food-derived bioactive compounds with anti-aging potential for nutricosmetic and cosmeceutical products." Critical Reviews in Food Science and Nutrition, August 10, 2020, 1–16. http://dx.doi.org/10.1080/10408398.2020.1805407.

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Kondo, Rogério Nabor, Airton Dos Santos Gon, and Paulo Muller Ramos. "Uso de nutricosmético à base de proteoglicanos em alopecias não cicatriciais em crianças e adolescentes." Surgical & Cosmetic Dermatology 12, no. 3 (2020). http://dx.doi.org/10.5935/scd1984-8773.20201233645.

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LONNI, Audrey Alesandra Stinghen Garcia, Bruna Fernanda Nunes RUIZ, Clisia Mara CARREIRA, Karina Fernandes RUIZ, Guilherme Henrique Dantas PALMA, and Vanessa Francisquini GONÇALVES. "NUTRICOSMETICS: AN INNOVATIVE CONCEPT." Visão Acadêmica 15, no. 2 (October 22, 2014). http://dx.doi.org/10.5380/acd.v15i2.36722.

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Devido à grande expansão do segmento de cosméticos novos produtos são lançados no mercado em velocidade acelerada. Para se destacar entre tantos lançamentos é necessário possuir um diferencial. Nos últimos anos este diferencial surgiu como um novo conceito de produto, os nutricosméticos. Conhecidos como pílulas da beleza são a combinação de alimento, cosmético e medicamento e promovem a boa aparência através de um organismo saudável. O grande diferencial dos nutricosméticos em relação aos cosméticos convencionais é que ele é administrado por via oral e não topicamente, por isso diz ser capaz de promover a beleza de dentro para fora. São suplementos alimentares que contém ingredientes ativos capazes de produzir variados efeitos no organismo como ação antienvelhecimento cutâneo, antiacne, redução da adiposidade cutânea, fotoproteção, antiqueda capilar, entre outros. Embora seja notável o esforço da comunidade científica em comprovar a eficácia destes compostos ainda se faz necessário muitos estudos nesta área, principalmente tratando-se da segurança destes produtos. Esta revisão tem como objetivo elucidar o conceito de nutricosméticos, bem como apresentar estudos clínicos que comprovam a eficácia de determinados compostos ativos. Esclarecer como a agência de vigilância sanitária (ANVISA) classifica estes novos produtos e qual é o perfil do consumidor e as estratégias de marketing para atingi-lo. Todos os aspectos desta revisão contribuem para um entendimento holístico do impacto deste novo conceito no mercado cosmético.

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Renato Inca-Torres, Alberto, Anabell Urbina-Salazar, Valeria Inca-Torres, and Juan Bautista. "Obtaining Protein Hydrolyzates By-products of Agaricus Bisporus." ESPOCH Congresses: The Ecuadorian Journal of S.T.E.A.M., August 29, 2021. http://dx.doi.org/10.18502/espoch.v1i2.9516.

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The mushroom industry generates non-marketable by-products that are not used or misused, these by-products are rich in protein and other beneficial compounds for health. Currently there is great interest in products rich in protein from agro-industrial waste, in this study was used mushroom by-products to obtain protein concentrates and isolates in order to improve functional properties, using a biotechnological process based on the use of proteases, with an effective approach for the maximum recovery of the components, maintaining their quality and effectiveness. It was used 4 different proteases (Alcalasa®, Flavourzyme®, Papain and Bioprotease LA-450) to determine which of them is most effective, the most efficient proteases that lead to a higher hydrolysis degree is used Bioprotease LA-450 and Alcalasa® (6.65 ± 0.6 and 6.21 ± 0.9) respectively, obtaining a higher amount of solubilized products (46.3 ± 3.6% and 41.7 ± 3%), as well as the Bioprotease LA-450, who presents a higher content of total proteins (51. 9 ± 4.8). This hydrolyzate, due to its composition: rich in amino acids, oligopeptides and peptides, can be used as a biofertilizer in agronomy, and as a nutraceutical or nutricosmetic in food or cosmetics. Keywords: Agaricus bisporus, Enzymes, Protein hydrolysates, By-product. Resumen La industria del champiñón genera subproductos no comercializables que no se utilizan o mal utilizan, estos subproductos son ricos en proteínas y otros compuestos beneficiosos para la salud. Actualmente existe gran interés en los productos ricos en proteína provenientes de residuos agroindustriales, en este estudio se utilizó los subproductos del champiñón para obtener concentrados y aislados de proteínas con el fin de mejorar las propiedades funcionales, utilizando un proceso biotecológico basado en el uso de proteasas, con un enfoque efectivo para la recuperación máxima de los componentes, manteniendo su calidad y efectividad. Se usó 4 diferentes proteasas (Alcalasa®, Flavourzyme®, Papaína y Bioproteasa LA-450) para determinar cuál de ellas es la más efectiva, las proteasas más eficientes que conducen a un mayor grado de hidrólisis es cuando se utilizan la Bioproteasa LA-450 y la Alcalasa® (6,65 ± 0,6 y 6,21 ± 0,9) respectivamente, obteniéndose mayor cantidad de productos solubilizados (46,3 ± 3,6% y 41,7 ± 3%), así como la Bioproteasa LA-450 que presenta mayor contenido de proteínas totales (51,9±4,8). Este hidrolizado debido a su composición: rico en aminoácidos, oligopéptidos y péptidos puede ser utilizado como biofertilizante en agronomía, y nutracéutico o nutricosmético en alimentación o cosmética. Palabras Clave: Agaricus bisporus, Enzimas, Hidrolizados proteicos, Subproducto.

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DESMIATY, YESI, and BERNA ELYA. "UNRIPE FRUIT OF RUBUS FRAXINIFOLIUS AS A POTENTIAL SOURCE OF ANTIOXIDANT AND ANTIELASTASE AGENT." International Journal of Applied Pharmaceutics, February 10, 2021, 78–81. http://dx.doi.org/10.22159/ijap.2021.v13s2.15.

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Objective: This research aimed to examine the anti-oxidant activity, antielastase activity, and the content of total phenolic and total flavonoid of R. fraxinifolius unripe fruit. Methods: The dried unripe fruit was extracted using Soxhlet apparatus with sequence solvent: n-hexane, ethyl acetate, and methanol. Each extract was determined the anti-oxidant and antielastase activity, total phenolic, and total flavonoid content. Result: The result showed the extracts (n-hexane, ethyl acetate, and methanol) gave anti-oxidant IC50>200; 186.84; and 19.74 ppm, and the ability of elastase inhibition was 6.84+0.9%; 52.23+7.1%; and 57.81+5.5% at 100 ppm, respectively. The methanolic extract contained phenolic 202.2 mg GAE/g extract and flavonoid 43.89 mg QE/g extract. Conclusion: R. fraxinifolius unripe fruit has shown potential as a DPPH (α, α-diphenyl-β-picrylhydrazyl) radical scavenger and anti-elastase. This study provides an excellent effect to underline the importance of R. fraxinifolius unripe fruit, and it can be developed as nutricosmetics, nutraceuticals, or herbal anti-wrinkle cosmetics.

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Journal articles on the topic 'Nutricosmetic'

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