Relevant bibliographies by topics / NX11

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'NX11'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "NX11"

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Li, Ying, Yeou-cherng Bor, Mark P. Fitzgerald, Kevin S. Lee, David Rekosh, and Marie-Louise Hammarskjold. "AnNXF1mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor." Molecular Biology of the Cell 27, no. 24 (December 2016): 3903–12. http://dx.doi.org/10.1091/mbc.e16-07-0515.

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The Nxf1 protein is a major nuclear export receptor for the transport of mRNA, and it also is essential for export of retroviral mRNAs with retained introns. In the latter case, it binds to RNA elements known as constitutive transport elements (CTEs) and functions in conjunction with a cofactor known as Nxt1. The NXF1 gene also regulates expression of its own intron-containing RNA through the use of a functional CTE within intron 10. mRNA containing this intron is exported to the cytoplasm, where it can be translated into the 356–amino acid short Nxf1(sNxf1) protein, despite the fact that it is a prime candidate for nonsense-mediated decay (NMD). Here we demonstrate that sNxf1 is highly expressed in nuclei and dendrites of hippocampal and neocortical neurons in rodent brain. Additionally, we show that sNxf1 localizes in RNA granules in neurites of differentiated N2a mouse neuroblastoma cells, where it shows partial colocalization with Staufen2 isoform SS, a protein known to play a role in dendritic mRNA trafficking. We also show that sNxf1 forms heterodimers in conjunction with the full-length Nxf1 and that sNxf1 can replace Nxt1 to enhance the expression of CTE-containing mRNA and promote its association with polyribosomes.
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Gales, Jón Pol, Julie Kubina, Angèle Geldreich, and Maria Dimitrova. "Strength in Diversity: Nuclear Export of Viral RNAs." Viruses 12, no. 9 (September 11, 2020): 1014. http://dx.doi.org/10.3390/v12091014.

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The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing. This strategy allows the cell to guarantee the conformity of the messengers accessing the cytoplasm and the translation machinery. Most transcripts are exported by the exportin dimer Nuclear RNA export factor 1 (NXF1)–NTF2-related export protein 1 (NXT1) and the transcription–export complex 1 (TREX1). Some mRNAs that do not possess all the common messenger characteristics use either variants of the NXF1–NXT1 pathway or CRM1, a different exportin. Viruses whose mRNAs are synthesized in the nucleus (retroviruses, the vast majority of DNA viruses, and influenza viruses) exploit both these cellular export pathways. Viral mRNAs hijack the cellular export machinery via complex secondary structures recognized by cellular export factors and/or viral adapter proteins. This way, the viral transcripts succeed in escaping the host surveillance system and are efficiently exported for translation, allowing the infectious cycle to proceed. This review gives an overview of the cellular mRNA nuclear export mechanisms and presents detailed insights into the most important strategies that viruses use to export the different forms of their RNAs from the nucleus to the cytoplasm.
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Aibara, Shintaro, Eugene Valkov, Meindert H. Lamers, Lyudmila Dimitrova, Ed Hurt, and Murray Stewart. "Structural characterization of the principal mRNA-export factor Mex67–Mtr2 fromChaetomium thermophilum." Acta Crystallographica Section F Structural Biology Communications 71, no. 7 (June 27, 2015): 876–88. http://dx.doi.org/10.1107/s2053230x15008766.

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Members of the Mex67–Mtr2/NXF–NXT1 family are the principal mediators of the nuclear export of mRNA. Mex67/NXF1 has a modular structure based on four domains (RRM, LRR, NTF2-like and UBA) that are thought to be present across species, although the level of sequence conservation between organisms, especially in lower eukaryotes, is low. Here, the crystal structures of these domains from the thermophilic fungusChaetomium thermophilumare presented together with small-angle X-ray scattering (SAXS) andin vitroRNA-binding data that indicate that, not withstanding the limited sequence conservation between different NXF family members, the molecules retain similar structural and RNA-binding properties. Moreover, the resolution of crystal structures obtained with theC. thermophilumdomains was often higher than that obtained previously and, when combined with solution and biochemical studies, provided insight into the structural organization, self-association and RNA-binding properties of Mex67–Mtr2 that facilitate mRNA nuclear export.
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Talhouarne, Gaëlle J. S., and Joseph G. Gall. "Lariat intronic RNAs in the cytoplasm of vertebrate cells." Proceedings of the National Academy of Sciences 115, no. 34 (August 6, 2018): E7970—E7977. http://dx.doi.org/10.1073/pnas.1808816115.

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Most intronic RNAs are degraded within seconds or minutes after their excision from newly formed transcripts. However, stable intronic sequence RNAs (sisRNAs) have been described from oocytes of the frog Xenopus, from Drosophila embryos, and from human cell lines. In Xenopus oocytes, sisRNAs are abundant in both the nucleus and cytoplasm, they occur in the form of lariats, and they are stable for days. In this study we demonstrate that cytoplasmic sisRNAs are also found in human, mouse, chicken, and zebrafish cells. They exist as circular (lariat) molecules, mostly 100–500 nucleotides in length, and are derived from many housekeeping genes. They tend to have an unusual cytosine branchpoint (with the exception of those from the frog). Stable lariats are exported from the nucleus to the cytoplasm by the NXF1/NXT1 system, demonstrating that their presence in the cytoplasm is not due to passive diffusion. Lariats in the cytoplasm are not associated with transcripts of the genes from which they are derived. The biological significance of cytoplasmic sisRNAs remains obscure.
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Aibara, Shintaro, Jun Katahira, Eugene Valkov, and Murray Stewart. "The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA." Nucleic Acids Research 43, no. 3 (January 27, 2015): 1883–93. http://dx.doi.org/10.1093/nar/gkv032.

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Zhang, Zi Chao, Neal Satterly, Beatriz M. A. Fontoura, and Yuh Min Chook. "Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1." Molecular Biology of the Cell 22, no. 23 (December 2011): 4657–68. http://dx.doi.org/10.1091/mbc.e11-03-0222.

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In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline–tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus. Here biochemical and cellular studies to understand the energetic organization of the NXF1 PY-NLS reveal unexpected redundancy in the nuclear import pathways used by NXF1. Human NXF1 can be imported via importin β, karyopherin β2, importin 4, importin 11, and importin α. Two NLS epitopes within the N-terminal tail, an N-terminal basic segment and a C-terminal R-X2-5-P-Y motif, provide the majority of binding energy for all five karyopherins. Mutation of both NLS epitopes abolishes binding to the karyopherins, mislocalized NXF1 to the cytoplasm, and significantly compromised its mRNA export function. The understanding of how different karyopherins recognize human NXF1, the examination of NXF1 sequences from divergent eukaryotes, and the interactions of NXF1 homologues with various karyopherins reveals the evolutionary development of redundant NLSs in NXF1 of higher eukaryotes. Redundancy of nuclear import pathways for NXF1 increases progressively from fungi to nematodes and insects to chordates, potentially paralleling the increasing complexity in mRNA export regulation and the evolution of new nuclear functions for NXF1.
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Wendt, Lisa, Janine Brandt, Bianca S. Bodmer, Sven Reiche, Marie Luisa Schmidt, Shelby Traeger, and Thomas Hoenen. "The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression." Cells 9, no. 1 (January 11, 2020): 187. http://dx.doi.org/10.3390/cells9010187.

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Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors. Recently, we performed a genome-wide siRNA screen that identified the nuclear RNA export factor 1 (NXF1) as an important host factor for the EBOV life cycle. NXF1 is a major component of the nuclear mRNA export pathway that is usurped by many viruses whose life cycles include nuclear stages. However, the role of NXF1 in the life cycle of EBOV, a virus replicating in cytoplasmic inclusion bodies, remains unknown. In order to better understand the role of NXF1 in the EBOV life cycle, we performed a combination of co-immunoprecipitation and double immunofluorescence assays to characterize the interactions of NXF1 with viral proteins and RNAs. Additionally, using siRNA-mediated knockdown of NXF1 together with functional assays, we analyzed the role of NXF1 in individual aspects of the virus life cycle. With this approach we identified the EBOV nucleoprotein (NP) as a viral interaction partner of NXF1. Further studies revealed that NP interacts with the RNA-binding domain of NXF1 and competes with RNA for this interaction. Co-localization studies showed that RNA binding-deficient, but not wildtype NXF1, accumulates in NP-derived inclusion bodies, and knockdown experiments demonstrated that NXF1 is necessary for viral protein expression, but not for viral RNA synthesis. Finally, our results showed that NXF1 interacts with viral mRNAs, but not with viral genomic RNAs. Based on these results we suggest a model whereby NXF1 is recruited into inclusion bodies to promote the export of viral mRNA:NXF1 complexes from these sites. This would represent a novel function for NXF1 in the life cycle of cytoplasmically replicating viruses, and may provide a basis for new therapeutic approaches against EBOV, and possibly other emerging viruses.
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Chappaz, Stéphane, Charity W. Law, Mark R. Dowling, Kirstyn T. Carey, Rachael M. Lane, Linh H. Ngo, Vihandha O. Wickramasinghe, Gordon K. Smyth, Matthew E. Ritchie, and Benjamin T. Kile. "Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice." Blood Advances 4, no. 7 (April 1, 2020): 1270–83. http://dx.doi.org/10.1182/bloodadvances.2019001323.

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Abstract In eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The highly conserved protein nuclear RNA export factor1 (Nxf1) is an important mediator of this process. Although studies in yeast and in human cell lines have shed light on the biochemical mechanisms of Nxf1 function, its contribution to mammalian physiology is less clear. Several groups have identified recurrent NXF1 mutations in chronic lymphocytic leukemia (CLL), placing it alongside several RNA-metabolism factors (including SF3B1, XPO, RPS15) whose dysregulation is thought to contribute to CLL pathogenesis. We report here an allelic series of germline point mutations in murine Nxf1. Mice heterozygous for these loss-of-function Nxf1 mutations exhibit thrombocytopenia and lymphopenia, together with milder hematological defects. This is primarily caused by cell-intrinsic defects in the survival of platelets and peripheral lymphocytes, which are sensitized to intrinsic apoptosis. In contrast, Nxf1 mutations have almost no effect on red blood cell homeostasis. Comparative transcriptome analysis of platelets, lymphocytes, and erythrocytes from Nxf1-mutant mice shows that, in response to impaired Nxf1 function, the cytoplasmic representation of transcripts encoding regulators of RNA metabolism is altered in a unique, lineage-specific way. Thus, blood cell lineages exhibit differential requirements for Nxf1-mediated global mRNA export.
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Braun, Isabelle C., Andrea Herold, Michaela Rode, and Elisa Izaurralde. "Nuclear Export of mRNA by TAP/NXF1 Requires Two Nucleoporin-Binding Sites but Not p15." Molecular and Cellular Biology 22, no. 15 (August 1, 2002): 5405–18. http://dx.doi.org/10.1128/mcb.22.15.5405-5418.2002.

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ABSTRACT Metazoan NXF1/p15 heterodimers promote export of bulk mRNA through nuclear pore complexes (NPC). NXF1 interacts with the NPC via two distinct structural domains, the UBA-like domain and the NTF2-like scaffold, which results from the heterodimerization of the NTF2-like domain of NXF1 with p15. Both domains feature a single nucleoporin-binding site, and they act synergistically to promote NPC translocation. Whether the NTF2-like scaffold (and thereby p15) contributes only to NXF1/NPC association or is also required for other functions, e.g., to impart directionality to the export process by regulating NXF1/NPC or NXF1/cargo interactions, remains unresolved. Here we show that a minimum of two nucleoporin-binding sites is required for NXF1-mediated export of cellular mRNA. These binding sites can be provided by an NTF2-like scaffold followed by a UBA-like domain (as in the wild-type protein) or by two NTF2-like scaffolds or two UBA-like domains in tandem. In the latter case, the export activity of NXF1 is independent of p15. Thus, as for the UBA-like domain, the function of the NTF2-like scaffold is confined to nucleoporin binding. More importantly, two copies of either of these domains are sufficient to promote directional transport of mRNA cargoes across the NPC.
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Forler, Daniel, Gwénaël Rabut, Francesca D. Ciccarelli, Andrea Herold, Thomas Köcher, Ricarda Niggeweg, Peer Bork, Jan Ellenberg, and Elisa Izaurralde. "RanBP2/Nup358 Provides a Major Binding Site for NXF1-p15 Dimers at the Nuclear Pore Complex and Functions in Nuclear mRNA Export." Molecular and Cellular Biology 24, no. 3 (February 1, 2004): 1155–67. http://dx.doi.org/10.1128/mcb.24.3.1155-1167.2004.

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ABSTRACT Metazoan NXF1-p15 heterodimers promote the nuclear export of bulk mRNA across nuclear pore complexes (NPCs). In vitro, NXF1-p15 forms a stable complex with the nucleoporin RanBP2/Nup358, a component of the cytoplasmic filaments of the NPC, suggesting a role for this nucleoporin in mRNA export. We show that depletion of RanBP2 from Drosophila cells inhibits proliferation and mRNA export. Concomitantly, the localization of NXF1 at the NPC is strongly reduced and a significant fraction of this normally nuclear protein is detected in the cytoplasm. Under the same conditions, the steady-state subcellular localization of other nuclear or cytoplasmic proteins and CRM1-mediated protein export are not detectably affected, indicating that the release of NXF1 into the cytoplasm and the inhibition of mRNA export are not due to a general defect in NPC function. The specific role of RanBP2 in the recruitment of NXF1 to the NPC is highlighted by the observation that depletion of CAN/Nup214 also inhibits cell proliferation and mRNA export but does not affect NXF1 localization. Our results indicate that RanBP2 provides a major binding site for NXF1 at the cytoplasmic filaments of the NPC, thereby restricting its diffusion in the cytoplasm after NPC translocation. In RanBP2-depleted cells, NXF1 diffuses freely through the cytoplasm. Consequently, the nuclear levels of the protein decrease and export of bulk mRNA is impaired.
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Dissertations / Theses on the topic "NX11"

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Ligorio, Danilo. "Virtual commissioning di una macchina automatica per la messa in passo di prodotti." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.

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L’obiettivo di questo elaborato di tesi è quello di testare ed analizzare le tecnologie del virtual commissioning messe a disposizione da Siemens, applicate a un caso reale. Il caso di studio preso in esame riguarda una macchina industriale di proprietà della Sitma Machinery S.p.A. per il confezionamento di generi alimentari. Nello specifico il virtual commissioning verrà applicato al modulo di macchina atto alla messa in passo dei prodotti tramite nastri trasportatori.
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Floyd, Jennifer A. "Nxf1 is the modifier vibrator : altering gene expression through mRNA export /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3166404.

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Juillard, Franceline. "Etude des mécanismes permettant l'accumulation cytoplasmique de certains ARNm viraux par la protéine EB2 du virus d'Epstein-Barr : rôle des facteurs cellulaires TAP/NFX1 et SRp20." Thesis, Lyon, École normale supérieure, 2011. http://www.theses.fr/2011ENSL0621.

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La protéine EB2 du virus d'Epstein-Barr (EBV) est une protéine du cycle réplicatif du virus indispensable à la production de particules virales. Elle permet l’accumulation dans le cytoplasme de certains ARNm viraux issus de gènes dépourvus d’intron. Pour mettre en évidence les mécanismes qui permettent à EB2 d’exporter ses ARNm cibles dans le cytoplasme, nous avons identifié différents partenaires cellulaires d’EB2 et nous avons étudié certaines de ces interactions d’un point de vue fonctionnel. Nous avons pu montrer qu’EB2 recrute directement le facteur général d'export des ARNm, TAP/NXF1, ce qui lui permet d’être exportée du noyau vers le cytoplasme. Puis nous avons montré qu’EB2 interagit avec SRp20, une protéine impliquée notamment dans la régulation de l'épissage et l'export des ARNm cellulaires. Cette interaction entre EB2 et SRp20 est indispensable pour l’accumulation dans le cytoplasme de certains ARNm cibles d’EB2, notamment parce que SRp20 semble permettre le recrutement d'EB2 sur ces ARNm. Enfin, nous avons montré qu’EB2 forme un dimère et nous avons caractérisé le domaine de la protéine responsable de cette interaction. La dimérisation d'EB2 semble essentielle pour que la protéine interagisse avec certains de ses partenaires comme SRp20 ou encore REF
The Epstein-Barr virus (EBV) protein EB2 is an early protein essential for the production of infectous virions. EB2 allows the cytoplasmic accumulation of a subset of viral mRNAs derived from intronless genes. To highlight the mecanisms by which EB2 exports his targets mRNA, we identified cellular partners and studied the functional role of some of these interactions. We showed that EB2 recruits directly the cellular mRNA export factor TAP/NXF1 and this interaction allows EB2’s shuttling between the nucleus and the cytoplasm. The we showed that EB2 interacts with SRp20, a cellular protein implicated in splicing regulation and mRNA export. This interaction is essential for the efficient cytoplasmic accumulation of some EB2 target mRNAs, partly because SRp20 appears to be able to recruit EB2 on these mRNAs. Then we showed that EB2 dimerises and we characterized the domain necessary for this interaction. This dimerisation appears to be essential for EB2’s interaction with several partners, including SRp20 and REF
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Pimienta, Genaro. "Structural characterization of a protein-RNA complex human TAP-NXF1 protein-retroviral CTE RNA /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973946571.

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Van, Der Graaf Kevin. "Understanding the importance of RNA export factor, Nxt1, during the metamorphosis and in ovaries in Drosophila melanogaster." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/115800/.

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The RNA export pathway is vital for export-competent mRNA to be exported from the nucleus to the cytoplasm. Without this pathway, RNA is unable to be translated into proteins for their function. A hetero-dimer comprised of Nxt1-Nxf1 is required to bind to the export-competent mRNA for a functional interaction between Nxf1 and the nuclear pore complex. Without Nxt1, Nxf1 interacts less effectively with the complex. In this thesis, the importance of Nxt1 is further examined during metamorphosis and in ovaries. I have shown that a reduction of functional Nxt1 during metamorphosis affects the muscle integrity in third instar larvae. This, in turn, affects the migration of the air bubble, which moves from the posterior to the anterior end, leading to dead pupae with no head eversion. Increasing the expression of a single gene, abba, rescues the muscle phenotype, but not the pupa viability. Further examination of differentially expressed genes revealed that genes with many and long introns were the most affected. In the ovaries, I have shown that Nxt1 is important in the piRNA pathway. Microarray and qRT-PCR have shown that transposons are de-repressed with less Nxt1, leading to sterility and death. Two rounds of small RNA-sequencing were performed, however, discrepancies between the two rounds made it difficult to analyse the data. Either Nxt1 influences the derepression of transposons or Nxt1 has a mild effect on de-repression of transposons and is more involved in the silencing process. Together with our collaborators we also got a first insight into which potential Nxf protein is interacting with Nxt1 in the piRNA pathway.
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Fernandes, Pereira Carina. "The influenza A virus NS1 protein and viral mRNA nuclear export." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275570.

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Influenza A virus (IAV) replication and transcription occur in the host cell nucleus; a feature which means both the viral genome (vRNA) and mRNA must be exported from the nucleus to the cytoplasm. The mechanism by which vRNA nuclear export is achieved has been well characterised, but how viral mRNAs are exported is poorly understood. The cellular NXF1-dependent mRNA export pathway has been shown to be involved in the export of some viral mRNAs, but how they are recruited to this pathway is unknown. Prior work from our laboratory showed that segment 7 mRNA was inefficiently exported to the cytoplasm in a sub-viral ‘minireplicon’ system, providing the first indication that there were viral requirements for IAV mRNA nuclear export. Further addition of individual viral polypeptides was tested and the effect on segment 7 mRNA export was analysed by fluorescent in situ hybridization (FISH) and confocal microscopy. This identified the NS1 protein as the viral factor required for efficient segment 7 nuclear export. Mutational studies on NS1 were carried out to unveil the mechanistic role of this protein in viral mRNA nuclear export, by plasmid transfection as well as in the context of recombinant viruses. These approaches indicated that both functional domains of NS1 were necessary to preserve the mRNA export function. Furthermore, these mutant proteins were used to examine the association between NS1 and the NXF1-dependent pathway in the context of mRNA nuclear export. Protein-protein and protein-RNA binding assays indicated that interactions between NXF1 and NS1, and NXF1 and segment 7 mRNA were necessary, but not sufficient to promote segment 7 viral mRNA export. Lastly, the role of NS1 protein in the nuclear export of viral mRNAs from other genome segments was studied. The intracellular localisation of most viral mRNAs was not affected by the absence of NS1 or the presence of an export-incompetent NS1 mutant protein. However, segment 4 mRNA exhibited a similar phenotype to segment 7 mRNA in showing a dependence on NS1 for efficient nuclear export. Overall, the results presented in this dissertation suggest that NS1 acts as an adaptor protein between the viral RNA synthesis machinery and cellular export pathway. This provides deeper insights for the characterization of a recently identified function of the IAV NS1 protein, of being required for the efficient nuclear export of mRNA from “late” kinetic class viral genes.
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ROSENBLATT, THOMAS. "Structures uniaxiales p(nx1) dans le systeme pb/cu(110) : etude par simulation des phases non alliees et alliees." Paris 6, 1996. http://www.theses.fr/1996PA066365.

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On presente une etude de simulation de la serie des structures uniaxiales p(nx1), avec n=4, 17, 13, 9, 14, 19, 5, des couches bidimensionnelles de plomb sur un substrat (110) de cuivre, aux taux de recouvrement proches de la monocouche. Ces structures ont ete mises en evidence anterieurement par differentes techniques experimentales. Nous avons etudie les structures non alliees et alliees par deux techniques de simulation: relaxation statique, (minimisation de forces interatomiques au zero absolu) et simulation monte carlo a temperatures elevees. Des potentiels de paires et des potentiels a n corps du type liaison forte ont ete employes. Les configurations d'energie potentielle minimale des structures non alliees p(4x1) et p(5x1) ont ete determinees par relaxation statique. L'isotherme d'adsorption, taux de recouvrement versus pression d'etalement, a la temperature du zero absolu a ete calculee pour les structures p(nx1) non alliees a l'aide d'un modele issu du modele de frenkel-kontorova. Ces calculs n'ont pas permis de demontrer la stabilite meme relative des structures intermediaires a la p(4x1) et la p(5x1). Un essai de calcul de l'energie libre de ces memes structures a temperatures superieures au zero absolu par une integration thermodynamique, n'a pas change les conclusions des etudes a 0 k. Dans une derniere partie, les structures d'equilibre de la couche de plomb sur la face (110) du cuivre, determinees par le calcul des bilans d'energie potentielle accompagnant la transformation des couches non alliees en alliages de surface, ont permis d'etablir la stabilite de phases alliees a bas et a haut taux de recouvrement, en accord avec des resultats experimentaux recents
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Hradil, Roman. "Návrh technologie výroby vybrané součásti v systému regulace parní turbíny." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318648.

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The subject of this thesis is the design of production technology of the hydraulic cylinder – the part of servomotor of a steam turbine control valve. The main precondition is a perspective technology of manufacturing the component on a single workplace using Siemens NX10 CAM system. The implementation of this work was carried out in cooperation with the Siemen, s.r.o., the branch of Industrial Turbomachinery in Brno. Part of the thesis is a brief introduction to the issue of steam turbines. The main part is devoted to analysis of a selected component in terms of technology, design of the best strategy of production technology and its implementation. The conclusion deals with the technical and economic assessment of the proposal.
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Celebi, Haluk. "Energy-Efficient Algorithms and Access Schemes for Small Cell Networks." Thesis, 2020. https://doi.org/10.7916/d8-1a3y-nx10.

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Dense deployment of small base stations (SBSs) brings new challenges such as growing energy consumption, increased carbon footprint, higher inter-cell interference, and complications in handover management. These challenges can be dealt with by taking advantage of sleep/idle mode capabilities of SBSs, and exploiting the delay tolerance of data applications, as well as utilizing information derived from the statistical distributions of SBSs and user equipment (UE)-SBS associations. This dissertation focuses on the formulation of mathematical models and proposes energy efficient algorithms for small cell networks (SCN). It is shown that delay tolerance of some data applications can be taken advantage of to save energy in SCN. This dissertation introduces practical models to study the performance of delayed access to SCNs. Operational states of SBS are modeled as a Markov chain and their probability distributions are analyzed. Also, it argues that SCN can be operated to save energy during low traffic periods by taking advantage of user equipments' (UEs) delay tolerance in SCN while providing high access probability within bounded transmission range. Dense deployment of SCNs cause an increase in overlapping SBS coverage areas, allowing UEs to establish communication with multiple SBSs. A new load metric as a function of the number of SBSs in UE's communication range is defined, and its statistics are rigorously analyzed. Energy saving algorithms based on aforementioned load metric are developed and their efficiencies are compared. Besides, UE's delay tolerance allows establishing communication with close-by SBSs that are either in fully active mode or in sleeping mode. Improvements in coverage probability and bitrate are analyzed by considering different delay tolerance values for UEs. Key parameters such as UE's communication range are optimized with respect to SBS density and delay tolerance. The fundamental problem of local versus remote edge/fog computing and its inherent tradeoffs are studied from a queuing perspective taking into account user/SBS density, server capacity and latency constraints. The task offloading problem is cast as an M/M/1(c) queue in which CPU intensive tasks arrive according to Poisson process and receive service subject to a tolerable delay. The higher the proportion of locally computed tasks, the less traffic SCN handles between edge processor and UE. Therefore, low utilization of SCN can be interperted as increased spectral efficiency due to low interference and close UE-SBS distance. Tradeoff between delay dependent SCN utilization and spectral efficiency is evaluated at high and low traffic loads.
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Pimienta, Genaro [Verfasser]. "Structural characterization of a protein-RNA complex : human TAP-NXF1 protein-retroviral CTE RNA / presented by Genaro Pimienta." 2004. http://d-nb.info/973946571/34.

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Books on the topic "NX11"

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Star Nx15 Printer (Sams Computerfacts). Sams, 1988.

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Star Nx10 Version 2 Printer/Book (Computerfacts Series). Sams, 1987.

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Stephen M Samuel P.E. and Adam Ericksen Ph D. Basic to Advanced Computer Aided Design Using NX12: Modeling, Drafting, Assemblies & Sheetmetal. Design Visionaries Inc, 2018.

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Book chapters on the topic "NX11"

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Nöldgen, Markus. "3D-Modellierung von Brücken- und Ingenieurbauwerken mit NX10: Einführungsbeispiele." In BIM im Brücken- und Ingenieurbau, 3–70. Wiesbaden: Springer Fachmedien Wiesbaden, 2016. http://dx.doi.org/10.1007/978-3-658-12875-3_1.

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Hashimoto, Shinichi. "Nx1-Seq (Well Based Single-Cell Analysis System)." In Single Molecule and Single Cell Sequencing, 51–61. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6037-4_4.

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Golubkova, Elena, Anna Atsapkina, Anna K’ergaard, and Ludmila Mamon. "Spermatogenesis in Drosophila melanogaster: Key Features and the Role of the NXF1 (Nuclear Export Factor) Protein." In Animal Models in Medicine and Biology. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90917.

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Conference papers on the topic "NX11"

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Emsia, Ali, Quang Trung Le, Dieter Briggmann, and Franko Küppers. "WDM-PON budget extension techniques for Nx10 Gbit/s DPSK signals." In SPIE OPTO, edited by Benjamin B. Dingel, Raj Jain, and Katsutoshi Tsukamoto. SPIE, 2013. http://dx.doi.org/10.1117/12.2002579.

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"Budget Extension Schemes for Nx10 Gbit/s DPSK-based TDM/WDM PON." In International Conference on Optical Communication Systems. SciTePress - Science and and Technology Publications, 2012. http://dx.doi.org/10.5220/0004057603730377.

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Mösler, I. "Primär metastasiertes Endometriumcarcinom. 4-Jähriges follow up. ED 2014: pTIVb(FIGOIVB)NxM1(pulmonal und ossär)G2." In 62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – DGGG'18. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1671540.

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Абдуллин, Марат, Marat Abdullin, Антон Глазычев, Anton Glazychev, Валериян Муфтеев, Valeriyan Mufteev, Марат Талыпов, et al. "Features of Modelling the Highway Route Using a Single Spatial “B-spline” Curve of a High Degree." In 29th International Conference on Computer Graphics, Image Processing and Computer Vision, Visualization Systems and the Virtual Environment GraphiCon'2019. Bryansk State Technical University, 2019. http://dx.doi.org/10.30987/graphicon-2019-1-169-171.

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Abstract:
The Russian road system is an important part of the transport structure. High wear, difficulty in driving, and a decrease in road safety lead to a decrease in the number of transportation in the country. In addition, imperfect road geometry does not allow increasing the speed mode on the highway. This article presents the features of the route simulation, taking into account the above disadvantages. The geometric aspects of the design of the road route in the plan are considered. Disadvantages and limitations of existing tracing methods are shown. The task is to select and adapt a geometric modeling program to solve the problems of high-quality road tracing in the plan. The «FairCurveModeler» program is proposed for geometric modelling of high quality curves according to smoothness criteria. A comparative testing of the methods of the «FairCurveModele»r program with the methods of the top CAD system «NX12» is carried out. The results obtained allow for a smoother construction of curves in the design of automobile and other routes.
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Malone, Clare F., Neekesh V. Dharia, Guillaume Kugener, Brenton Paolella, Michael Rothberg, Mai Abdusamad, Alfredo Gonzalez, et al. "Abstract 2878: CRISPR-Cas9 screens identify the nuclear export factor NXT1 as a novel therapeutic target inMYCN-amplified neuroblastoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2878.

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Malone, Clare F., Neekesh V. Dharia, Guillaume Kugener, Brenton Paolella, Michael Rothberg, Mai Abdusamad, Alfredo Gonzalez, et al. "Abstract 2878: CRISPR-Cas9 screens identify the nuclear export factor NXT1 as a novel therapeutic target inMYCN-amplified neuroblastoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2878.

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