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Journal articles on the topic 'O'Brien Score'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

O'Brien, Michael L. "Further Evidence of the Validity of the O'Brien Multiphasic Narcissism Inventory." Psychological Reports 62, no. 3 (1988): 879–82. http://dx.doi.org/10.2466/pr0.1988.62.3.879.

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This study examined further aspects of the validity of the O'Brien Multiphasic Narcissism Inventory. The current research sought to determine whether the factorial structure of the O'Brien scales derived from a clinical population resembled that extracted from responses of the normal subjects studied previously and whether the clinical population would score higher than the normal subjects. Analyses showed that the O'Brien scales were highly congruent for the two populations and the clinical population scored significantly higher on all three of the O'Brien scales than the normal population. I

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2

Hidayanto, Danang Rohmat, Agus Kristiyanto, and Sapta Kunta Purnama. "Development Model of Basic Technique Skills Training Shot-Put Obrien Style Based Biomechanics Review." International Journal of Multicultural and Multireligious Understanding 5, no. 3 (2018): 167. http://dx.doi.org/10.18415/ijmmu.v5i3.253.

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The background of this research is the unavailability of learning model of basic technique technique of O'Brien style force that integrated in skill program based on biomechanics study which is used as a reference to build the basic technique skill of the O'Brien style force among students. The purpose of this study is to develop a model of basic-style technique of rejecting the O'Brien-style shot put based on biomechanical studies for beginner levels, including basic prefix technique, glide, final stage, repulsion, further motion and repulsion performance of O'Brien style, all of which arrang

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3

Hattori, Yasunori, Kazuteru Doi, Emmanuel P. Estrella, and Guofen Chen. "ARTHROSCOPICALLY ASSISTED REDUCTION WITH VOLAR PLATING OR EXTERNAL FIXATION FOR DISPLACED INTRA-ARTICULAR FRACTURES OF THE DISTAL RADIUS IN THE ELDERLY PATIENTS." Hand Surgery 12, no. 01 (2007): 1–12. http://dx.doi.org/10.1142/s021881040700333x.

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Twenty-eight patients older than 70 years with AO type C fracture of the distal radius were treated with arthroscopically assisted reduction combined with volar plating or external fixation. The patients were followed up for an average of 24.9 ± 16.1 months. The average score was 80.1 ± 10.5 according to the modified system of Green and O'Brien. Eight patients had an excellent result, 11 had a good result, seven had a fair result, and two had a poor result. Twenty-three patients were able to return to their previous activities level or occupation without any restriction. On the basis of these

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Wang, Feng Lan, Yuan Jun Yao, Fa Yun Gong, Fang Ping Ye, and Wen Jie Qi. "Liquid-Solid Coupling Characteristics in the Fluidized Bed Evaporator for Tobacco Refined Liquid." Applied Mechanics and Materials 686 (October 2014): 522–28. http://dx.doi.org/10.4028/www.scientific.net/amm.686.522.

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Consider a two-phase liquid-solid coupling effect, using Euler - Euler two-fluid model is solved using standard viscous term with k-ε model and the velocity pressure coupling a simple algorithm to simulate liquid-solid two-phase flow characteristics of the fluid flow method bed, the applicability of the model to assess the drag. Different effects of a two-stage flow characteristics of fluidized bed flow characteristics, fluid and operating conditions affect the physical properties of the paper. We found from the simulation is the use of different drag coefficient models will greatly affect the

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Syah, Amirul, Harizahayu Harizahayu, Gamar Al Haddar, Annisah Annisah, and Emy Yunita Rahma Pratiwi. "Improving Students' Mathematical Problem-Solving Ability through the Use of External Representations." Journal on Education 5, no. 2 (2023): 5313–23. http://dx.doi.org/10.31004/joe.v5i2.1274.

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This study has the objectives, namely first, to find out whether students' mathematical problem-solving abilities can be improved by using external representations. Second, analyzing student activities in learning mathematics by using external representations. Third, analyzing student responses to learning mathematics by using external representations. This research uses classroom action research (CAR) or classroom action testing (PTK) methods. According to O'Brien in Mulyatiningsih, "action research is carried out when a group of people (students) identify the problem, then the researcher det

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Comparison of percutaneous screw fixation versus conservative treatment for fractures of the waist of scaphoid." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 1 (2024): 111–17. https://doi.org/10.5281/zenodo.15363591.

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<strong>Abstract</strong> <strong>Background:</strong> Scaphoid waist fracture is a common type of wrist fracture, accounting for 51% to 90% of wrist fractures. The aim of present study was to evaluate the effectiveness of surgical compared with conservative treatments for fractures of the waist of scaphoid. <strong>Method: </strong>A total 64 consecutive patients with fractures of the waist of scaphoid were randomly allocated to Percutaneous fixation with a cannulated Acutrak screw or immobilisation in a cast. The range of movement, grip and pinch strength, modified Green/O’Brien functi

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Minami, Akio, Hiroyuki Kato, and Norimasa Iwasaki. "Treatment of Scapholunate Dissociation: Ligamentous Repair Associated with Modified Dorsal Capsulodesis." Hand Surgery 08, no. 01 (2003): 1–6. http://dx.doi.org/10.1142/s0218810403001443.

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We previously reported that our repair and/or reconstruction of the scapholunate interosseous ligament reduced the scapholunate dissociation and improved the clinical results. Re-evaluation of these patients after three years revealed that malrotation of the scaphoid advanced significantly although the clinical results declined only slightly. To prevent progression of scaphoid malrotation, a modified dorsal capsulodesis was subsequently added to the ligamentous repair of scapholunate dissociation. The records of 17 patients were available for this study. The time lapse from injury to surgical

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Reardon, G., D. Rayson, J. Chang, K. Gelmon, and G. Dranitsaris. "Identifying patients at high risk for neutropenic complications during chemotherapy for metastatic breast cancer (MBC) with doxorubicin or pegylated liposomal doxorubicin: Development of a prediction model." Journal of Clinical Oncology 25, no. 18_suppl (2007): 6598. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.6598.

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6598 Background: Despite the effectiveness of anthracycline (ACH) therapy in the adjuvant and MBC settings, neutropenic complications (NC) remain a common and often unpredictable problem. Consequences may include dose reductions or delays in chemotherapy, or hospitalization for fever or infection. This study describes the development of a cycle-based risk prediction model for NC during chemotherapy with traditional doxorubicin (DOX) or a pegylated liposomal formulation (PLD) for MBC. Methods: Data analyzed was from a randomized clinical trial of MBC patients (n=509), who received chemotherapy

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O'Brien, M. E., M. Duh, L. Chen, et al. "Is symptom improvement in patients with small cell lung cancer (SCLC) associated with clinical response? An analysis using the Patient Symptom Assessment Lung Cancer (PSALC) scale in a randomized trial comparing oral topotecan (OT) with best supportive care (BSC)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 7725. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7725.

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7725 Background: SCLC is a highly symptomatic disease with poor survival in prior treated patients. To evaluate the role of chemotherapy, a recent multicenter trial randomized 141 patients with prior treatment to receive either OT + BSC or BSC only. This was the first trial to use a BSC control group in SCLC while evaluating survival, response and symptoms. Survival data were reported (O'Brien et al JCO 2006; median survival of 25.9 weeks on OT + BSC vs 13.9 weeks on BSC, p = 0.01). 51% on OT had “disease control” (partial response [PR] + stable disease [SD]); no patient on BSC was reported to

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Del Fabbro, Egidio, Rony Dev, David Hui, Lynn Palmer, and Eduardo Bruera. "Effects of Melatonin on Appetite and Other Symptoms in Patients With Advanced Cancer and Cachexia: A Double-Blind Placebo-Controlled Trial." Journal of Clinical Oncology 31, no. 10 (2013): 1271–76. http://dx.doi.org/10.1200/jco.2012.43.6766.

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Purpose Prior studies have suggested that melatonin, a frequently used integrative medicine, can attenuate weight loss, anorexia, and fatigue in patients with cancer. These studies were limited by a lack of blinding and absence of placebo controls. The primary purpose of this study was to compare melatonin with placebo for appetite improvement in patients with cancer cachexia. Patients and Methods We performed a randomized, double-blind, 28-day trial of melatonin 20 mg versus placebo in patients with advanced lung or GI cancer, appetite scores ≥ 4 on a 0 to 10 scale (10 = worst appetite), and

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Buontempo, Peter, Ronald G. Jubin, Cathy Buontempo, et al. "Pegylated Carboxyhemoglobin Bovine (SANGUINATE®) Restores RBCs Roundness and Reduces Pain during a Sickle Cell Vaso-Occlusive Crisis." Blood 130, Suppl_1 (2017): 969. http://dx.doi.org/10.1182/blood.v130.suppl_1.969.969.

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Abstract Background: Pain during Vaso-Occlusive Crisis (VOC) is a hallmark of sickle cell disease (SCD) as deoxygenated (sickled) red blood cells (RBC) aggregate in the microvasculature due to Hemoglobin S (HbS) polymerization. PEGylated carboxyhemoglobin bovine (PEG-COHb; SANGUINATE®) was designed as a gas transfer agent to depolymerize HbS resulting from hypoxia. Prior in vitro studies have shown PEG-COHb capability to transfer carbon monoxide (CO) and oxygen (O2) to SCD hypoxic RBCs, reversing sickling. A prospective, randomized, single-dose Phase II clinical study is in progress (NCT024117

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Dybko, Jaroslaw, Ewa Medras, Olga Haus, Bozena Jazwiec, Tomasz Wrobel, and Kazimierz Kuliczkowski. "The Hasford Score Correlates with the Long-Term Molecular Response to Imatinib Treatment for Chronic Myeloid Leukemia Patients and May be Useful for Differentiating Low and Intermediate Risk Patients: A Single Institution Experience." Blood 124, no. 21 (2014): 3152. http://dx.doi.org/10.1182/blood.v124.21.3152.3152.

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Abstract BACKGROUND: Since the beginning of the tyrosine-kinase inhibitor (TKI) era in the treatment of chronic myeloid leukemia (CML), there have been attempts to stratify patients for optimal management. An essential requirement for perfect stratification was the identification of factors capable of predicting long-term response [1]. The Sokal and Hasford scores were developed in the chemotherapy and interferon alfa eras, respectively [2]. The EUTOS score was found to predict probability of complete cytogenetic response (CCyR) within 18 months of Imatinib initiation and progression-free surv

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CARR, ROSALIND. "A POLITE AND ENLIGHTENED LONDON?" Historical Journal 59, no. 2 (2016): 623–34. http://dx.doi.org/10.1017/s0018246x16000042.

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The character of eighteenth-century English society remains a subject of debate, and diverse perspectives are particularly pronounced when it comes to the cultural influence and power of politeness. The monographs discussed below all engage with politeness in different ways. Emma Major and Sarah Apetrei explore the means by which polite culture facilitated female cultural agency, and thus follow Lawrence Klein's call to comprehend the lived experience of politeness. Taking a different tack, Simon Dickie and Vic Gatrell reject the idea that politeness enjoyed the cultural dominance ascribed to

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Jacobson, Amanda E., Sara K. Vesely, Myra Christian-Rancy, and Sarah H. O'Brien. "Mobile Application Vs. Paper Pictorial Blood Assessment Chart to Track Menses in Young Women: A Randomized Cross-over Design." Blood 128, no. 22 (2016): 1006. http://dx.doi.org/10.1182/blood.v128.22.1006.1006.

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Abstract Background Heavy menstrual bleeding (HMB) is the most common symptom for women with bleeding disorders. Major barriers to performing research in this field are difficulties in quantifying and tracking changes in menstrual bleeding, particularly in adolescents. The Pictorial Blood Assessment Chart (PBAC) score is often used to quantify severity of menstrual bleeding1. However, the traditional paper diary PBAC score is fraught with recall bias and compliance issues in adolescents. Utilizing mobile applications (apps) has great potential for improving health by assisting with behavior mo

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Beagan, Jonathan, Suzanne Wardell, Travis Clark, et al. "Abstract PS9-07: Epigenomic Characterization of ER Transcriptional Activation via Liquid Biopsy." Clinical Cancer Research 31, no. 12_Supplement (2025): PS9–07—PS9–07. https://doi.org/10.1158/1557-3265.sabcs24-ps9-07.

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Abstract Background: Endocrine therapies (ET) are a cornerstone treatment for estrogen receptor-positive (ER+) breast cancer (BC). ET’s efficacy depends on the transcriptional addiction of the cancer cells to estrogen receptor signaling, for which there is no current clinical test. ER IHC and ESR1 mutations are insufficient proxies for ER transcriptional dependency. A blood-based biomarker for dynamic measurement of the ER transcriptional dependency of a tumor would greatly improve our ability to identify patients who would most benefit from continued ET. Methods: We profiled key epigenomic de

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Takahashi, Koichi, Hagop M. Kantarjian, Preetesh Jain, et al. "Propensity Score Matched Comparison of Dasatinib and Nilotinib As a Frontline Therapy in Newly Diagnosed CML with Chronic Phase." Blood 124, no. 21 (2014): 1802. http://dx.doi.org/10.1182/blood.v124.21.1802.1802.

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Abstract Background: Dasatinib (DAS) and nilotinib (NIL) are standard frontline therapy for chronic myeloid leukemia, chronic phase (CML-CP) based on randomized trials compared to imatinib. However, DAS and NIL have not been compared directly. The purpose of this study is to analyze efficacy, long-term outcome and toxicity of DAS and NIL as a front line therapy in newly diagnosed CML-CP. Method: Newly diagnosed patients (pts) with CML-CP, who received front-line therapy by either one of the phase II trials conducted almost in parallel (DAS: NCT00254423, N = 102 and NIL: NCT00129740, N = 104) a

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Mueller, Joerg P., Nils O'Brien, Franz Osl, et al. "Abstract 1876: ROCKETS Science: A novel processing toolbox for light sheet microscopy reveals unknown binding sites for EpCAM-targeted antibodies." Cancer Research 82, no. 12_Supplement (2022): 1876. http://dx.doi.org/10.1158/1538-7445.am2022-1876.

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Abstract Summary: We present a novel light sheet fluorescence microscopy (LSFM)-based imaging platform and corresponding set of procedures for greatly improved preclinical investigation of the biodistribution of novel drug candidates by the example of an EpCAM-targeting antibody. Methods: An anti-EpCAM antibody (G.8.8R) was applied intravenously to mice. Whole mice or individual organs were optically cleared following novel protocols, which we termed Rapid Optical Clearing Kit for Enhanced Tissue Scanning (ROCKETS). The procedures enabled processing of mouse organs and entire bodies for LSFM.

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McCabe, Chantal E., Erik Jessen, Daniel R. O'Brien, Julia E. Wiedmeier-Nutor, Susan L. Slager, and Esteban Braggio. "Abstract 3352: Identifying copy number variations in chronic lymphocytic leukemia using targeted next generation sequencing." Cancer Research 82, no. 12_Supplement (2022): 3352. http://dx.doi.org/10.1158/1538-7445.am2022-3352.

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Abstract Chronic lymphocytic leukemia (CLL) is characterized by multiple copy number abnormalities (CNVs) with prognostic value. Identifying these structural variations is central to defining CLL pathogenesis, risk stratification, and therapeutic approaches. Fluorescence in situ hybridization (FISH) is the clinical gold standard in detecting prognostic CNVs in CLL. However, next-generation sequencing (NGS) techniques have become more readily available for clinical genomic applications and can also be used to identify CNVs. Here we present bioinformatic methods to accurately identify CNVs in CL

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Shimano, Kristin A., Amanda B. Grimes, Melissa J. Rose, et al. "Efficacy Findings in a Phase 3, Randomized Trial of Eltrombopag Vs. Standard First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia in Children." Blood 144, Supplement 1 (2024): 709. https://doi.org/10.1182/blood-2024-193644.

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Background: First-line treatments for patients (pts) with newly diagnosed immune thrombocytopenia (ITP) include corticosteroids, intravenous immunoglobulin (IVIg), and anti-D globulin. Eltrombopag (epag), a thrombopoietin receptor agonist, was FDA approved for children with chronic ITP in 2015. The efficacy of epag in the newly diagnosed phase of pediatric ITP is unknown. Methods: The Pediatric ITP Newly diagnosed pts Epag vs Standard therapy (PINES) trial, NCT03939637, is an investigator-initiated, prospective, open label, randomized, multi-center trial sponsored by the ITP Consortium of Nort

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Herman, Sarah E. M., Mohammed Farooqui, Rahel Bezabhie, Georg Aue, and Adrian Wiestner. "In Vivo Effects of Ibrutinib On BCR Signaling, Tumor Cell Activation and Proliferation in Blood and Tissue-Resident Cells of Chronic Lymphocytic Leukemia Patients." Blood 120, no. 21 (2012): 185. http://dx.doi.org/10.1182/blood.v120.21.185.185.

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Abstract Abstract 185 The B-cell receptor (BCR) pathway regulates the survival, proliferation, and migration of chronic lymphocytic leukemia (CLL) cells. Bruton's tyrosine kinase (BTK) is activated downstream of the BCR and has been shown to be up-regulated in CLL cells compared to normal B-cells. Ibrutinib (PCI-32765), a specific covalently-bound inhibitor to BTK, disrupts several key signaling pathways. In vitro, ibrutinib has been shown to induce apoptosis in tumor cells and prevents induced proliferation of cultured chronic lymphocytic leukemia (CLL) cells (Herman et al., Blood 2011). Simi

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Babau, Martin, Florence Joly, Frederic Fiteni, et al. "Abstract P3-08-25: randomized phase III study comparing the digital telemonitoring platform “CUREETY TECHCARE” to usual standard of care in patients with triple negative metastatic breast cancer initiating a first-line systemic treatment: ALTERNATIVE." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–08–25—P3–08–25. https://doi.org/10.1158/1557-3265.sabcs24-p3-08-25.

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Abstract Background: Triple-negative breast cancer (TNBC), accounts for 15% to 20% of all breast cancers. It is characterized by the absence of 3 receptors (estrogen/progesterone/human epidermal growth factor 2) which limits the treatment options. Currently a therapeutic sequence for patients with mTNBC is first-line chemotherapy with or without immunotherapy, followed by sacituzumab govitecan then by successive chemotherapy lines. Considering the toxicity of these treatments there is a need to identify and monitor the signs and symptoms (S&S) of adverse events (AE). Early identification o

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Pantel, Austin R., Kara Maxwell, Anthony Young, et al. "Abstract P2-07-04: [18F]FluorThanatrace PET imaging correlates with response to PARP inhibitors in breast cancer: a pilot study." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–07–04—P2–07–04. https://doi.org/10.1158/1557-3265.sabcs24-p2-07-04.

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Abstract Introduction: PARP inhibitors (PARPi) are approved for BRCA-mutant HER2- breast cancer, and there is clinical interest in expanding indications to include homologous recombination deficient (HRD) breast cancers. Yet, response in these populations remains variable, suggesting clinical utility in developing a better biomarker to select patients for PARPi and predict response. Here, we evaluated the 18F-labeled PARPi, [18F]FluorThanatrace (FTT), as a functional biomarker of PARPi response in breast cancer. Methods: A single-arm prospective observational trial was conducted at the Univers

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Quintás-Cardama, Alfonso, Hagop M. Kantarjian, Rajyalakshmi Luthra, et al. "Efficacy of Frontline Nilotinib Therapy in Patients (Pts) with Newly Diagnosed Philadelphia Chromosome (Ph)-Positive Chronic Myeloid Leukemia in Early Chronic Phase (CML-CP)." Blood 118, no. 21 (2011): 454. http://dx.doi.org/10.1182/blood.v118.21.454.454.

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Abstract Abstract 454 Efficacy of Frontline Nilotinib Therapy in Patients (Pts) with Newly Diagnosed Philadelphia Chromosome (Ph)-Positive Chronic Myeloid Leukemia in Early Chronic Phase (CML-CP) Alfonso Quintás-Cardama, Hagop Kantarjian, Raja Luthra, Susan O'Brien, Elias Jabbour, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Stefan Faderl, Marina Konopleva, William Wierda, Elizabeth Burton, Jorge Cortes 1MD Anderson Cancer Center, University of Texas, Houston, TX Background: In 2005, we initiated a phase II study of nilotinib as 1st line therapy in pts with newly diagnosed CML-C

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Stover, Daniel, Dominik Hlauschek, Erica Mayer, et al. "Abstract GS03-07: Protocol-defined biomarker analysis in the PALLAS (AFT-05) adjuvant trial: Genomic subtype derived from RNA sequencing of HR+/HER2- early breast cancer." Cancer Research 84, no. 9_Supplement (2024): GS03–07—GS03–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs03-07.

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Abstract Background. The phase 3 PALLAS trial (NCT02513394) compared two years of the CDK4/6 inhibitor palbociclib with endocrine therapy of provider choice, versus endocrine therapy alone, as adjuvant treatment for patients with Stage II-III hormone receptor-positive HER2-negative (HR+/HER2-) breast cancer. Genomic subtype (PAM50 intrinsic subtype) measured from whole-transcriptome RNA sequencing data was defined in the protocol of the PALLAS trial as the primary biomarker for analysis of prediction and prognosis. Clinical data have been previously presented (Gnant et al, JCO 2022), and the t

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Choo, *Hye-In, Young-A. Lee, and Yukiori Goto. "FOOD ADDICTION AND RELATIONSHIPS WITH OTHER ADDICTIVE BEHAVIORS IN KOREAN YOUNG ADULTS." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i305—i306. https://doi.org/10.1093/ijnp/pyae059.542.

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Abstract Background Addiction is the term used for various forms of uncontrolled, compulsive seeking and taking processes, ranging from risky abuse of substances such as heroin and fentanyl to addictive behaviors such as gambling and kleptomania [1, 2]. Recently, highly palatable foods, including those rich in sugars and fats and thereby high glycemic index, are also suggested to cause addiction, referring as food addiction [3]. However, there have been still large debates whether such foods could really be addictive, as well as whether food addiction is the addiction to substances (foods) or

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Harling, Philip, and Peter Mandler. "From “Fiscal-Military” State to Laissez-faire State, 1760–1850." Journal of British Studies 32, no. 1 (1993): 44–70. http://dx.doi.org/10.1086/386020.

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The recent historiographical revolution in our understanding of the eighteenth-century state has broad implications, analytical as well as empirical, that are only beginning to be plumbed. Due largely to the work of Patrick O'Brien and John Brewer, the old picture—of a small, amateurish, corrupt central apparatus largely maintained (between sporadic wars) to dignify the crown and assist gentlemanly (i.e., parliamentary) plunder—has been pretty completely effaced. We now see that by the end of the French wars the British state was one of the largest and most efficient in Europe; certainly it en

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Sadler, Brooke, Charles Minard, Gabe Haller, et al. "Genotype Analysis of Adolescents with Heavy Menstrual Bleeding and Low Von Willebrand Activity - Report of a Multi-Center Study." Blood 136, Supplement 1 (2020): 19–20. http://dx.doi.org/10.1182/blood-2020-135886.

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Introduction: Low von Willebrand factor (VWF) activity is prevalent in adolescents with heavy menstrual bleeding (HMB). There is a need to better genetically characterize these patients and improve our understanding of the pathophysiology of their bleeding risk. Methods: One of the main objectives of this multi-center, single arm, observational cohort study was to genotype adolescent females with HMB and low VWF (≥ 30 and ≤ 50 IU/dL) by means of whole exome sequencing (WES), to identify variants throughout the exome that may modulate risk for bleeding. Post-menarchal females &lt; 21 years

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Stephens, Deborah M., Anna Moseley, Brian T. Hill, et al. "Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Evolve CLL/SLL Study (SWOG S1925; NCT#04269902)." Blood 138, Supplement 1 (2021): 2630. http://dx.doi.org/10.1182/blood-2021-144780.

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Abstract Background: Currently, asymptomatic patients with CLL/SLL are observed without treatment until development of symptoms or cytopenias. Historically, early intervention studies in patients with CLL/SLL with non-specific chemoimmunotherapy agents have not resulted in an overall survival (OS) benefit and have resulted in toxicity. The introduction of targeted therapies, such as venetoclax (an oral BCL2 inhibitor; V) and obinutuzumab (an intravenous anti-CD20 monoclonal antibody; O), have provided tolerable/efficacious options for patients with CLL. In the CLL14 study, symptomatic patients

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Lee, Hyun Gu, and Woo-Jeong Shim. "Analysis of Research Trends in Career Aspirations: Focusing on Keyword Network Analysis." Institute for Educational Research 37, no. 4 (2024): 1–29. https://doi.org/10.35283/erft.2024.37.4.1.

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Purpose: This study systematically examines career aspiration research trends published in Korean academic journals over the past 20 years, providing insights for future research. Methods: A total of 131 articles published in Korea Citation Index (KCI)-listed journals from 2004 to June 2024 were analyzed. Both descriptive statistics and keyword network analysis were employed to analyze publication trends and thematic structures. Results: The findings revealed five major trends: (1) career aspiration research peaked between 2011 and 2013, coinciding with the implementation of career education p

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Pophali, Priyanka A., Xin Victoria Wang, Fengmin Zhao, et al. "Quality of Life in Patients <=70 Years of Age with Chronic Lymphocytic Leukemia Treated Frontline with Ibrutinib-Rituximab Versus Fludarabine Cyclophosphamide Rituximab: Analysis from ECOG-ACRIN E1912." Blood 138, Supplement 1 (2021): 1562. http://dx.doi.org/10.1182/blood-2021-150462.

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Abstract Background: The ECOG-ACRIN randomized phase 3 clinical trial E1912 established ibrutinib-rituximab (IR) as the standard of care for CLL patients &lt;= 70 years in the frontline setting by improving the progression free (PFS) and overall survival (OS) compared to previous standard chemo-immunotherapy with fludarabine, cyclophosphamide and rituximab (FCR) (Shanafelt et al. NEJM 2019). Quality of life (QOL) was an important secondary endpoint on this trial comparing continuous (IR) vs time-limited (FCR) therapy due to the differing profile of treatment-related toxicities over the sho

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Murphy, M., K. Bennett, S. Ryan, C. Hughes, A. Lavan, and C. Cadogan. "Interventions to optimise medication prescribing and adherence in older people with cancer: A systematic scoping review." International Journal of Pharmacy Practice 29, Supplement_1 (2021): i23—i24. http://dx.doi.org/10.1093/ijpp/riab015.027.

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Abstract Introduction Older adults with cancer often require multiple medications (polypharmacy) comprising cancer-specific treatments, supportive care medications (e.g. analgesics) and medications for pre-existing conditions. The reported prevalence of polypharmacy in older adults with cancer ranges from 13–92% (1). Increasing numbers of medications pose risks of potentially inappropriate prescribing and medication non-adherence. Aim The aim of this scoping review was to provide an overview of evaluations of interventions to optimise medication prescribing and/or adherence in older adults wit

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Dave, Dhruva, Natalie R. Gassman, Emily O'brein, Fibiana Oladipo, and Rebecca Arend. "Abstract 2099: Leveraging spatial transcriptomics and proteomics to assess the Immune response and DNA damage in high grade serous ovarian cancer (HGSOC) treated with neoadjuvant chemotherapy." Cancer Research 85, no. 8_Supplement_1 (2025): 2099. https://doi.org/10.1158/1538-7445.am2025-2099.

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Abstract Ovarian cancer is the sixth leading cause of cancer-related deaths among women in the United States. Many women (&gt;80%) with OC are diagnosed at an advanced stage and a 5-year survival rate of less than 30%. Newer therapies, such as antibody-drug conjugates (ADCs), have revolutionized the treatment landscape for solid tumors, including ovarian cancer. While platinum-based chemotherapy stays the stalwart in systemic therapy for OC treatment, most of these patients experience recurrence (&gt;50%) despite receiving standard of care therapy. Hence, significant efforts are made t

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Imtikhanah, Sobrotul, and Wiwik Lukmana. "EFFECT OF COMPETENCE OF THE APPARATUS, INTERNAL CONTROL SYSTEM AND LEGAL AUDITS ON STATE -OWNED ASSETS MANAGEMENT AND INFORMATION SYSTEM AS A MODERATING." Neraca 20, no. 2 (2024): 64–80. https://doi.org/10.48144/neraca.v20i2.1934.

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ABSTRACT This study aimed to examine and obtain empirical evidence regarding the effect of apparatus competence, information systems, legal audits, and internal control systems on the management of State -Owned Assets (a case study at the Technical Implementation Unit of the Regional Office of the Ministry of Law and Human Rights). Since the research was quantitative, it used multiple linier regression with SPSS version 16.0 as the method of data analysis. The sample was 36 respondents while the population was all users of the goods as Head of Subdivision of state property, administrator of st

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Towriss, Jake, Prosanta Mondal, Waleed Sabry, et al. "The Impact from Frontline CLL Chemo Immunotherapy Regimen Outcomes Based on Patient Tolerability." Blood 132, Supplement 1 (2018): 5551. http://dx.doi.org/10.1182/blood-2018-99-119462.

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Abstract Background: The addition of anti-CD20 monoclonal antibodies to chemotherapy regimens for Chronic Lymphocytic Leukemia (CLL) has led to significant improvements in response and survival (Burger, O'Brian, Nat Rev Clin Oncol 2018). However, toxicities with treatment exist and real world evidence suggests that tolerability of treatment protocols may differ than those established by clinical trials (Mato et. al. Am Soc Hematology 2017), making clinical treatment decisions challenging. This study retrospectively reviewed the tolerability of three front line chemo-immunotherapy options utili

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Zou, Guangyong, and Lily Zou. "A Nonparametric Global Win Probability Approach to the Analysis and Sizing of Randomized Controlled Trials With Multiple Endpoints of Different Scales and Missing Data: Beyond O'Brien–Wei–Lachin." Statistics in Medicine, October 17, 2024. http://dx.doi.org/10.1002/sim.10247.

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ABSTRACTMultiple primary endpoints are commonly used in randomized controlled trials to assess treatment effects. When the endpoints are measured on different scales, the O'Brien rank‐sum test or the Wei–Lachin test for stochastic ordering may be used for hypothesis testing. However, the O'Brien–Wei–Lachin (OWL) approach is unable to handle missing data and adjust for baseline measurements. We present a nonparametric approach for data analysis that encompasses the OWL approach as a special case. Our approach is based on quantifying an endpoint‐specific treatment effect using the probability th

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Shaji, Amal, Rahul Dey, and Shuhail Ashraf. "OSTEOPOROTIC DISTAL RADIUS FRACTURE: COMPARATIVE STUDY OF SURGICAL OUTCOME TREATED BY EXTERNAL FIXATOR AND VOLAR PLATING." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, March 1, 2023, 77–79. http://dx.doi.org/10.36106/ijsr/8915519.

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Background and Objective: Distal radius fractures are one of the most common fragility fractures among the osteoporotic population. The management of distal radius fracture has evolved so much from cast providing neutralization to bridging external xator later by buttress plates. There is still no clear consensus for management of distal radius fractures among osteoporotic age group. A randomized comparative study was undertaken to study functional outcome between closed reduction external xations over volar lock plating. 40 patients of distal radius Methods: fracture belong to the osteoporo

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Kapila, Rajesh, Kamal kumar arora, Utkarsha Utkarsha, Lokesh Chugh, Shweta Makker, and Jatinder Singh. "OUTCOMES OF CLOSED UNSTABLE DISTAL RADIUS FRACTURES OPERATED AND FIXED WITH VARIABLE ANGLE LOCKING PLATE." INDIAN JOURNAL OF APPLIED RESEARCH, October 1, 2021, 81–83. http://dx.doi.org/10.36106/ijar/0802970.

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INTRODUCTION AND AIM: This study aims to evaluate the functional and radiological outcomes in unstable distal end radius fractures treated with variable angle locking plates. MATERIAL AND METHODS: We reviewed 20 unstable distal end radius fractures that were operated and xed with variable-angle locking plate. RESULTS: According to Green and O'Brien Score (Cooney's modication) , excellent results were reported in 70 %,while good results were present in 20% cases, fair results were seen in 10% cases. CONCLUSION: The use of variable angle locking plates (VALP) in treating unstable distal end ra

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ÇAĞLAR, Ceyhun, Ali Said NAZLIGÜL, Batuhan AKBULUT, and Mustafa AKKAYA. "Clinical and functional analysis of closed reduction-plastering and volar locking plate methods in distal radius fractures in patients over 60 years of age." Ege Tıp Dergisi, December 18, 2022, 666–70. http://dx.doi.org/10.19161/etd.1208986.

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Aim: Many different methods have been described in the treatment of distal radius fractures (DRF) in the elderly population, and which one is the better method is a matter of debate among orthopedic surgeons. The aim of this study was to compare the results of closed reduction and plastering (CRP) and volar locking plate (VLP), which are used in the treatment of DRF in the elderly population. Materials and Methods: Between January 2019 and December 2020, 36 patients with DRF aged > 60 years were evaluated retrospectively. There were 19 patients in the CRP group and 17 patients in the

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Prasanth, S. P., Avinash Bajjuri, Batthina Sri Prabhav, and Anna Mohan Yadav. "OUTCOMES OF EXTERNAL FIXATION VERSUS VOLAR PLATING FOR COMMINUTED DISTAL RADIUS FRACTURES IN ADULTS: A PROSPECTIVE STUDY." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, January 1, 2024, 26–29. http://dx.doi.org/10.36106/ijsr/9706097.

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Introduction: Several treatment alternatives are accessible for individuals with an intraarticular distal radius fracture; however, in instances of comminuted fractures, the choices typically converge to either a volar locking plate, an external xator, or a combination of the two. A study was undertaken to investigate fracture healing and functional outcomes in distal radius fractures treated with external xation and plating. In Methods: this prospective study adult patients aged between 20- and 60-years with comminuted fracture wrist were recruited for the study. After preoperative by clini

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Ng, Wan Lin, Nurasyikin Kamarudin, Aqeel Anjum, Joe Devlin, Aidan O'Brien, and Alexander Fraser. "P099 Risk of obstructive sleep apnoea in patients with rheumatic disease: a prospective cohort study." Rheumatology 60, Supplement_1 (2021). http://dx.doi.org/10.1093/rheumatology/keab247.097.

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Abstract Background/Aims Sleep plays an important component in our lives and sleep abnormalities have been known to be linked with various rheumatic conditions. Obstructive sleep apnoea (OSA) could potentially affect the severity of rheumatic symptoms such as pain, fatigue and also influence the disease activity. This study aims to evaluate the risk of OSA in patients with rheumatic diseases in an Irish cohort. Methods Patients with a diagnosis of a rheumatic disease were recruited from rheumatology outpatients. These patients were asked to complete the Berlin Sleep Questionnaire (BSQ) to eval

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Yang, Yuanming, Kehan Rao, Kai Zhan, et al. "Clinical evidence of acupuncture and moxibustion for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials." Frontiers in Public Health 10 (November 24, 2022). http://dx.doi.org/10.3389/fpubh.2022.1022145.

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BackgroundAcupuncture and moxibustion have been widely used in the treatment of Irritable Bowel Syndrome (IBS). But the evidence that acupuncture and moxibustion for IBS reduction of symptom severity and abdominal pain, and improvement of quality of life is scarce.MethodsPubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wanfang Database, China Biomedical Literature Service System (SinoMed), and unpublished sources were searched from inception until June 30, 2022. The quality of RCTs was assessed with

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Coates, Laura C., Xenofon Baraliakos, Effie Pournara, et al. "P260 Secukinumab in Patients With Psoriatic Arthritis and Axial Manifestations: Predictors of Response From the Double-blind, Randomised, Phase 3b MAXIMISE Trial." Rheumatology 61, Supplement_1 (2022). http://dx.doi.org/10.1093/rheumatology/keac133.259.

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Abstract Background/Aims Psoriatic arthritis (PsA) is a heterogeneous disease with variability of response to different therapeutic modalities. Identifying potential demographic and disease characteristics as predictors of treatment response may define personalised treatment optimisation strategies. This post-hoc exploratory analysis of the MAXIMISE trial investigated the differential treatment effect of demographics and baseline characteristics as predictive factors in biologic-naïve patients with active PsA and symptoms of active spinal disease. Methods Full analysis set (FAS) comprised all

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