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Journal articles on the topic 'O.T. Joshua'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Wildenboer, Johan. "JOSHUA 24: SOME LITERARY AND THEOLOGICAL REMARKS." Journal for Semitics 24, no. 2 (2017): 484–502. http://dx.doi.org/10.25159/1013-8471/3465.

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Achenbach, R 2005. Pentateuch, Hexateuch und Enneateuch. Eine Verhältnisbestimmung, ZAR 11:122–154. Albertz, R 2007. Die kanonische Anpassung des Johuabuches. Ein Neubewertung seiner sog.”Priesterschriftelike Texte”, in Römer and Schmid 2007:199–217. Aurelius, E 2003. Zukunft jenseits des Gerichts: Eine redaktionsgeschichltliche Studie zumEnneateuch. BZAW 319. Berlin: de Gruyter. Barrick, W B & Spencer, J R (eds) 1984. In the shelter of Elyon: essays on ancient Palestinian life in honour of GW Ahlström. JSOTSup 31. Sheffield: JSOT Press. Becker U, 2006. Endredaktionelle Kontextvernetzungen

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2

Edelman, Diana. "Joshua 24 as Poetic Narrative. William T. Koopmans." Journal of Near Eastern Studies 52, no. 4 (1993): 308–10. http://dx.doi.org/10.1086/373645.

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Drugaş, Şerban George Paul. "Etymological Note about Romanian Raţă – Albanian Rosë." Hiperboreea 5, no. 1 (2018): 69–71. http://dx.doi.org/10.5325/hiperboreea.5.1.0069.

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4

Pajunen, Mika. "Joshua T. James, The Storied Ethics of the Thanksgiving Psalms." Journal of Semitic Studies 65, no. 1 (2020): 257–59. http://dx.doi.org/10.1093/jss/fgz045.

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Tellier, Joshua M., Brooke Winsmann, Michael Humphreys, Stella Minoudi, Alexandros Triantafyllidis, and Eric T. Schultz. "What Are You Doing Here? A Sculpin Endemic to Arkansas and Missouri (Cottus immaculatus) Appears in Connecticut." Ichthyology & Herpetology 111, no. 1 (2023): 1–7. https://doi.org/10.1643/i2020078.

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Tellier, Joshua M., Winsmann, Brooke, Humphreys, Michael, Minoudi, Stella, Triantafyllidis, Alexandros, Schultz, Eric T. (2023): What Are You Doing Here? A Sculpin Endemic to Arkansas and Missouri (Cottus immaculatus) Appears in Connecticut. Ichthyology & Herpetology 111 (1): 1-7, DOI: 10.1643/i2020078, URL: http://dx.doi.org/10.1643/i2020078

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Poe Hays, Rebecca W. "The Storied Ethics of the Thanksgiving Psalms. By Joshua T. James." Journal of Theological Studies 70, no. 2 (2019): 752–54. http://dx.doi.org/10.1093/jts/flz042.

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7

McNeur, Catherine. "Liquid Capital: Making the Chicago Waterfront. By Joshua A. T. Salzmann." Environmental History 24, no. 1 (2018): 214–15. http://dx.doi.org/10.1093/envhis/emy109.

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8

McClintock, Brett T., Erin E. Moreland, Joshua M. London, et al. "Quantitative assessment of species identification in aerial transect surveys for ice-associated seals." Marine Mammal Science 31, no. 3 (2015): 1057–76. https://doi.org/10.1111/mms.12206.

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McClintock, Brett T., Moreland, Erin E., London, Joshua M., Dahle, Shawn P., Brady, Gavin M., Richmond, Erin L., Yano, Kymberly M., Boveng, Peter L. (2015): Quantitative assessment of species identification in aerial transect surveys for ice-associated seals. Marine Mammal Science 31 (3): 1057-1076, DOI: 10.1111/mms.12206, URL: http://dx.doi.org/10.1111/mms.12206

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9

Fisher, Colin. "Liquid capital: Making the Chicago waterfront, edited by Joshua A. T. Salzmann." Journal of Urban Affairs 41, no. 2 (2018): 273–75. http://dx.doi.org/10.1080/07352166.2018.1483136.

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10

Goetz, Stewart. "On the Nature of Human Persons and the Resurrection of the Body." Journal of Analytic Theology 6 (December 22, 2018): 300–312. http://dx.doi.org/10.12978/jat.2018-6.181919061425.

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In this paper, I respond to Joshua Mugg and James T. Turner, Jr's claim that the doctrine of the resurrection requires the numerical sameness of ante- and post-mortem bodies. I argue that they have not shown that Scripture teaches this view and, therefore, that animalism, as opposed to substance dualism, does not offer a superior explanation for the necessity of the resurrection .

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11

Millar, Suzanna. "New Directions for Thinking about the Bible and Nonhuman Animals: A Review of Works by Peter Atkins, Dong Hyeon Jeong, and Saul Olyan." Vetus Testamentum 74, no. 1 (2024): 144–52. http://dx.doi.org/10.1163/15685330-00001160.

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Abstract Three new monographs have appeared in 2023 that explore the Bible and nonhuman animals: Peter Joshua Atkins, The Animalising Affliction of Nebuchadnezzar in Daniel 4: Reading Across the Human-Animal Boundary (London: T&T Clark, 2023; pp. xiv + 260); Dong Hyeon Jeong, Embracing the Nonhuman in the Gospel of Mark (Atlanta: SBL Press, 2023; pp. xii+177); Saul M. Olyan, Animal Rights and the Hebrew Bible (New York: OUP, 2023; pp. xii+144). This review brings these books into conversation, suggesting six questions that they grapple with and which might stimulate further research.

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12

Soloviy, Roman. "Joshua T. Searle. Theology After Christendom: Forming Prophets for a Post-Christian World." Theological Reflections: Euro-Asian Journal of Theology, no. 22 (April 17, 2019): 107–11. http://dx.doi.org/10.29357/2521-179x.2019.22.6.

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13

CALDERONI, FRANCESCO. "Migration, Culture Conflict, Crime and Terrorism, Joshua D. Freilich and Rob T. Guerette (eds)." Journal of Contingencies and Crisis Management 16, no. 1 (2008): 63–64. http://dx.doi.org/10.1111/j.1468-5973.2008.00532.x.

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14

Roan, Emily, Laura Tiu, Roy Yanong, Matthew DiMaggio, and Joshua Patterson. "Overview of Urban Aquaculture." EDIS 2019, no. 6 (2019): 6. http://dx.doi.org/10.32473/edis-fa217-2019.

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This 6-page fact sheet written by Emily H. Roan, Laura Tiu, Roy P.E. Yanong, Matthew A. DiMaggio, and Joshua T. Patterson and published by the UF/IFAS Program in Fisheries and Aquatic Sciences, School of Forest Resources and Conservation provides introductory information for people interested in engaging in commercial or hobby-scale aquaculture in urban or suburban areas. It introduces three common types of urban aquaculture systems, describes the resources and challenges unique to urban aquaculture, and includes a handy “getting started” section. https://edis.ifas.ufl.edu/fa217

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Daliman, Muner, Bambang Bahan, Hana Suparti, and Kristian Handoyo Sugiyarto. "The influence of a leadership model based on the book of Yoshua on the performance of Christian executive and legislative employees in Gurung Mas District, Central Kalimantan." Technium Social Sciences Journal 57 (May 9, 2024): 261–77. http://dx.doi.org/10.47577/tssj.v57i1.9707.

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One thing the world at this time needs is leadership. As a Christian, the bible contains countless figures who exhibit biblical leadership. In this day and age, Christian leadership is an uncommon and significant quality. Mrs. White even mentioned the traits of those who can stand up for what is right in the midst of chaos. Numerous individuals with this quality of leadership are mentioned in the Bible, including Joseph, Daniel, Paul, and even Jesus Christ, our Lord and Savior; however, the focus of this essay is Joshua, the man who succeeded. This paper is based on the identification results

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Schmitt, R. "Sahasram Ati Srajas. Edited by Dieter Gunkel, Joshua T. Katz, Brent Vine, and Michael Weiss." Kratylos 62, no. 1 (2017): 162–70. http://dx.doi.org/10.29091/kratylos/2017/1/4.

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Mason, L. "Freilich, Joshua D. and Guerette, Rob T. (Eds) (2006). MIGRATION, CULTURE CONFLICT, CRIME AND TERRORISM." Policing 2, no. 4 (2008): 509. http://dx.doi.org/10.1093/police/pan064.

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Bhandar, Davina. "Joshua D. Freilich and Rob T. Guerette eds. (2006) Migration, Culture Conflict, Crime and Terrorism." Journal of International Migration and Integration / Revue de l'integration et de la migration internationale 9, no. 3 (2008): 337–38. http://dx.doi.org/10.1007/s12134-008-0064-x.

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Kehr, Pierre. "David M. Dines, Joshua S. Dines, T. Bradley Edwards (eds): Reverse shoulder arthroplasty: a practical approach." European Journal of Orthopaedic Surgery & Traumatology 28, no. 8 (2018): 1651. http://dx.doi.org/10.1007/s00590-018-2255-2.

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20

Ferrell, Joshua, Xingyue He, Hongjing Qu, et al. "Abstract 3434: Evaluation of TCR-engineered T cells specific for KRAS G12V mutant peptide presented by HLA-A*02:01." Cancer Research 85, no. 8_Supplement_1 (2025): 3434. https://doi.org/10.1158/1538-7445.am2025-3434.

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Abstract Adoptive cellular therapies (ACT) have had limited success in the treatment of solid tumors. Recent approvals of both Tumor Infiltrating Lymphocyte (TIL) and T cell receptor-engineered T cell (TCR-T) therapies herald the promise of autologous T cell strategies. Unfortunately, existing therapeutics face significant challenges including an existing T cell response to immunogenic tumors (TILs) or relying on targets lacking tumor dependence (TCR-T). Engineered T cell therapies utilizing TCRs specific for public oncogenic driver mutations would overcome these hurdles with the intent of dri

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Chen, Wanyi, Avantika Gupta, Nicholas Mai, et al. "Abstract LB280: Resistance to trastuzumab deruxtecan (T-DXd) in breast cancer via loss of HER2 expression and binding." Cancer Research 85, no. 8_Supplement_2 (2025): LB280. https://doi.org/10.1158/1538-7445.am2025-lb280.

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Abstract Background: T-DXd is an antibody-drug conjugate (ADC) designed to deliver a topoisomerase I inhibitor to cancer cells expressing HER2. It is effective in breast cancer (BC) but resistance emerges over time. For many antibody-based drugs, loss of the antibody-binding epitope is a common mechanism of resistance. We investigated the potential for loss of HER2 binding to promote T-DXd resistance and pharmacologic strategies that could overcome this mechanism. Methods: Clinical samples of tissue biopsies from a cohort of BC patients treated with T-DXd were examined for HER2 expression by i

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22

Yu, Raymond, Yong Tong, Huarui Lu, et al. "Abstract 3432: A novel anti-CLDN6-CD137 bispecific antibody (NBL-028) for treating Claudin 6 positive solid tumors." Cancer Research 82, no. 12_Supplement (2022): 3432. http://dx.doi.org/10.1158/1538-7445.am2022-3432.

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Abstract Claudin-6 is a tetraspan membrane protein associated with tight junction formation. Its expression in normal tissues is restricted to the fetal organs but is not detected in the adult tissues. Increased expression of CLDN6 has been shown in several human malignancies such as testicular, ovarian, uterine, liver and lung adenocarcinoma, and is associated with poor prognosis in these cancer patients. Therefore, CLDN6 is a promising tumor-associated antigen (TAA) for tumor-targeting therapeutics such as CART and T cell engaging bispecific antibodies. CD137 co-stimulation has been reported

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Venkataraman, Sujatha, Ilango Balakrishnan, Lillie Leach, et al. "Abstract PR010: Developing a safe and potent tumor-targeting gated CAR-T cell therapy for DIPG: A deadly pediatric brain tumor." Cancer Research 84, no. 17_Supplement (2024): PR010. http://dx.doi.org/10.1158/1538-7445.pediatric24-pr010.

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Abstract Background: DIPG (Diffuse Intrinsic Pontine Glioma) is an aggressive pediatric brain tumor that infiltrates the pons and is uniformly fatal. Curative surgery is not possible, radiation therapy provides only temporary relief, and chemotherapy is not effective. There is a great interest in applying Chimeric Antigen Receptor (CAR) expressing T cells and CAR-T cell strategies to solid tumors like DIPG; however, doing so will require novel approaches in CAR-T cell design to make this therapy effective. We recently identified CD99 as a highly expressed antigen in DIPG cells and an immunothe

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Ramee, Shane, Joshua T. Patterson, Cortney L. Ohs, and Matthew DiMaggio. "Candidate Species for Florida Aquaculture: Gulf Killifish, Fundulus grandis." EDIS 2016, no. 2 (2016): 6. http://dx.doi.org/10.32473/edis-fa190-2016.

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The Gulf killifish is a promising species for commercial aquaculture in Florida with the potential to help diversify the marine baitfish aquaculture industry in Florida and throughout the southeastern United States. Methods for culturing this species have improved in the past decade. This 6-page fact sheet describes the new methods and some strategies to give producers greater control of reproduction, larval growth, and survival. The publication provides the information producers need to make the most informed decision possible when considering Gulf killifish aquaculture. Written by Shane W. R

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Sharifi, Marina N., Jamie M. Sperger, Amy K. Taylor, et al. "Abstract B041: High purity CTC RNA sequencing identifies poor prognosis lineage states in castrate resistant prostate cancer." Clinical Cancer Research 30, no. 21_Supplement (2024): B041. http://dx.doi.org/10.1158/1557-3265.liqbiop24-b041.

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Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR010) of the Conference Program/Proceedings. Citation Format: Marina N Sharifi, Jamie M Sperger, Amy K Taylor, Katharine E Tippins, Shannon R Reese, Viridiana Carreno, Katherine R Kaufmann, Alex H Chang, Luke A Nunamaker, Charlotte Linebarger, Kyle T Helzer, Matthew Bootsma, Grace C Blitzer, John Floberg, David Kosoff, Rana R McKay, Xiao X Wei, Shuang G Zhao, Joshua M Lang. High purity CTC RNA sequencing identifies poor prognosis lineage states in

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Hauksson, Egill. "State of stress from focal mechanisms before and after the 1992 landers earthquake sequence." Bulletin of the Seismological Society of America 84, no. 3 (1994): 917–34. http://dx.doi.org/10.1785/bssa0840030917.

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Abstract The state of stress in the Eastern California Shear Zone (ECSZ) changed significantly because of the occurrence of the 1992 Mw 6.1 Joshua Tree and the MW 7.3 Landers earthquakes. To quantify this change, focal mechanisms from the 1975 Galway Lake sequence, the 1979 Homestead Valley sequence, background seismicity from 1981 to 1991, and the 1992 Landers sequence are inverted for the state of stress. In all cases, the intermediate principal stress axis (S2) remained vertical, and changes in the state of stress consisted of variations in the trend of maximum and minimum principal stress

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Crosby, Wendy. "Sacred Language, Sacred World: The Unity of Scriptural and Philosophical Hermeneutics. By Joshua D. Broggi . London: Bloomsbury T&T Clark, 2016. x + 222 pages. $114.00." Horizons 44, no. 1 (2017): 204–5. http://dx.doi.org/10.1017/hor.2017.12.

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Sylus, Raichel M. "PSYCHO-SOCIAL PERSPECTIVES IN TANYA MENDONSA’S THE DREAMING HOUSE." Kongunadu Research Journal 4, no. 1 (2017): 29–31. http://dx.doi.org/10.26524/krj171.

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Tanya Mendonsa is a prolific contemporary writer, an abstract painter and more than everything, a lover. Two volumes of her poems entitled The Dreaming House, All the Answer I Shall Ever Get and an enchanting narration The Book of Joshua are published so far. A writer’s role to his/her role is inevitably a contributing one to her society. The object of “peeling back the layers of personal memory and experience” helps in understanding “the often irrational roots of human motivation, thoughts, and behaviour” (Kandel). In coordination with personal memory, Mendonsa’s early life and way of upbring

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Lipscomb, Barney. "Reviewers for Journal of the Botanical Research Institute of Texas, Volume 17, 2023." Journal of the Botanical Research Institute of Texas 17, no. 2 (2023): 541. http://dx.doi.org/10.17348/jbrit.v17.i2.1333.

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Reviewers for the Journal of the Botanical Research Institute of Texas, Volume 17: Abbott, J. Richard—Ackerfield, Jennifer—Allen, Geraldine—Almeida, Odair José Garcia de—Barrett, Russell—Bennett, Bradley C.—Briggler, Malissa—Brokaw, Joshua M.—Carter, Richard—Cohen, James—Costea, Mihai—Cripps, Cathy—Dillon, Michael O.—Franck, Alan R.—Fuentes, Sara—Gandhi, Kanchi—Goldenberg, Renato—Gostel, Morgan—Graham, Shirley A.—Gustafson, Mark P.—Hansen, Bruce F.—Harrower, Emma—Hellenthal, Barbara J.—Hernández, Alexis López—Higinio Sandoval-Ortega, Manuel—Holmgren, Pat—Howard, Rebecca—Keeley, Sterling—Keith,

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Chapman, Jennie. "Review: The Scarlet Woman and the Red Hand: Evangelical Apocalyptic Belief in the Northern Ireland Troubles by Joshua T. Searle." Nova Religio 20, no. 1 (2016): 146–48. http://dx.doi.org/10.1525/novo.2016.20.1.146.

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Lohr, Kathryn E., and Joshua T. Patterson. "Coral Reef Conservation Strategies for Everyone." EDIS 2016, no. 8 (2016): 7. http://dx.doi.org/10.32473/edis-fa199-2016.

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Corals are small animals related to jellyfish. Large groups of these animals live together and form huge interconnected colonies called reefs. Coral reefs are some of the most diverse ecosystems on the planet; an essential habitat for a wide variety of animal and plant species. About 400 million people rely on coral reef fish as a source of protein; about 6 million people make a living by catching and selling coral reef fish and invertebrates; tourism activities like SCUBA diving and snorkeling provide revenue of US $9.6 billion per year; and reefs reduce wave energy by 97%, helping to protect

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Cohn, David, Joshua O. Benditt, Scott Eveloff, and F. Dennis McCool. "Diaphragm thickening during inspiration." Journal of Applied Physiology 83, no. 1 (1997): 291–96. http://dx.doi.org/10.1152/jappl.1997.83.1.291.

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Cohn, David, Joshua O. Benditt, Scott Eveloff, and F. Dennis McCool. Diaphragm thickening during inspiration. J. Appl. Physiol. 83(1): 291–296, 1997.—Ultrasound has been used to measure diaphragm thickness ( T di) in the area where the diaphragm abuts the rib cage (zone of apposition). However, the degree of diaphragm thickening during inspiration reported as obtained by one-dimensional M-mode ultrasound was greater than that predicted by using other radiographic techniques. Because two-dimensional (2-D) ultrasound provides greater anatomic definition of the diaphragm and neighboring structure

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Chen, Wanyi, Joshua Drago, Avantika Gupta, Bo Liu, and Sarat Chandarlapaty. "Abstract 2111: Impact of HER2 Expression on trastuzumab deruxtecan(T-DXd) efficacy." Cancer Research 84, no. 6_Supplement (2024): 2111. http://dx.doi.org/10.1158/1538-7445.am2024-2111.

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Abstract Background: T-DXd is an FDA-approved anti-HER2 Antibody Drug Conjugate (ADC), which has shown clinical efficacy in breast cancers with either overexpression or low-level expression of HER2. The benefit of T-DXd across the spectrum of HER2 expression has called into question the relevance of HER2 expression level as relevant parameter for T-DXd sensitivity. We sought to experimentally address the relevance of HER2 expression level upon the degree of T-DXd response. Methods: A series of isogenic models was generated that expressed different levels of surface HER2 using a doxycycline-ind

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34

Phillips, Lisa. "Clark, Heweitt, Rosenzweig, Brier, Brown, & Foner, Eds., Who Built America? Working People And The Nation's Economy, Politics, Culture And Society, Vol. I; Lichtenstein, Strasser, Rosenzweig, Brier, Brown, Eds., Who Built America? Working People And T." Teaching History: A Journal of Methods 27, no. 1 (2002): 44–47. http://dx.doi.org/10.33043/th.27.1.44-47.

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Although not technically second editions, the volumes under review are based on the original Who Built America series sponsored by the American Social History Project and authored by Bruce Levine, Stephen Brier, David Brundage, Edward Countryman, Dorothy Fennell, and Marcus Rediker (volume one) and by Joshua Freeman, Nelson Lichtenstein, Stephen Brier, David Bensman, Susan Porter Benson, David Brundage, Bret Eynon, Bruce Levine, and Bryan Palmer (volume two), published in I 989. I have used volumes one and two of the most recent editions to teach both halves of the American history survey cour

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Mardpour, Soura, Mirella Georgouli, Ana Pereira Puri, et al. "Abstract 908: Tumour organoid-t cell co-culture assay to evaluate CAR t cell cytotoxicity." Cancer Research 83, no. 7_Supplement (2023): 908. http://dx.doi.org/10.1158/1538-7445.am2023-908.

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Abstract Recent advances in cancer immunotherapy had a positive impact on the life expectancy of patients for a large range of clinical indications. With new treatment strategies and druggable targets being identified at an increasing pace, the number of patients eligible for cancer immunotherapy is expected to expand steadily. However, promising therapeutic developments face hurdles in translating preclinical findings into therapy since conventional 2D cancer models hold low clinical predictive value. HUB developed an innovative alternative, build on the discovery that adult stem cells prolif

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Flanagan, Maureen A. "Kurt C. Schlichting. Waterfront Manhattan: From Henry Hudson to the High Line; Joshua A. T. Salzmann. Liquid Capital: Making the Chicago Waterfront." American Historical Review 124, no. 1 (2019): 263–65. http://dx.doi.org/10.1093/ahr/rhy438.

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Tagore, Joshua, Robert Norgard, Sia Penikalapati, et al. "Abstract B025: A T cell engager targeting cancer associated fibroblasts inhibits tumor growth and modulates the tumor microenvironment." Cancer Immunology Research 12, no. 10_Supplement (2024): B025. http://dx.doi.org/10.1158/2326-6074.tumimm24-b025.

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Abstract Fibroblast activating protein (FAP) is an attractive target for therapeutic intervention being mainly expressed in malignant tissues. Previous studies have targeted FAP using a variety of methods yet failed in clinics. Here, we utilize FAP-targeted T cell engager (TcE) in KPCY tumor models to recapitulate a pre-clinical environment. The use of FAP- TcE efficiently depleted FAP+ fibroblasts in vitro and in vivo from tumors. This resulted in bystander killing of tumor cells and tumor growth control in vivo. This therapeutic effect was not dependent on priming via lymph node activation a

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Shen, Hongxing, Fengyuan Huang, Xiangmin Zhang та ін. "Abstract 2864: Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling". Cancer Research 83, № 7_Supplement (2023): 2864. http://dx.doi.org/10.1158/1538-7445.am2023-2864.

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Abstract Therapeutic resistance to immune checkpoint blockers (ICBs) is a pressing issue, limiting ICB efficacy to a small proportion of cancer patients. Concerted efforts from our group and others have identified that loss of IFN-γ signaling genes in melanoma is a major mechanism of resistance to ICBs. However, strategies of overcoming this resistance have been largely elusive. Moreover, given the indispensable role of T cells in governing ICBs, little is known about how tumor-intrinsic loss of IFN-γ signaling impacts tumor-infiltrating T cells (TILs). In this study, we report that melanomas

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Tagore, Joshua R., Robert Joseph Norgard, Pratha Budhani, et al. "Abstract 2583: A T cell engager targeting cancer associated fibroblasts inhibits tumor growth and modulates the tumor microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 2583. https://doi.org/10.1158/1538-7445.am2025-2583.

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Abstract Fibroblast activating protein (FAP) is an attractive target for therapeutic intervention being mainly expressed in malignant tissues. Previous studies have targeted FAP using a variety of methods yet failed in clinics. Here, we utilize FAP-targeted T cell engager (TcE) in KPCY tumor models to recapitulate a pre-clinical environment. The use of FAP- TcE efficiently depleted FAP+ fibroblasts in vitro and in vivo from tumors. This resulted in bystander killing of tumor cells and tumor growth control in vivo. This therapeutic effect was not dependent on priming via lymph node activation a

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40

Aspray, Barnabas. "Sacred Language, Sacred World: The Unity of Scriptural and Philosophical Hermeneutics, Joshua D.Broggi, Bloomsbury T&T Clark, 2016 (ISBN 978-0-56766-486-0), x + 222 pp., hb £65." Reviews in Religion & Theology 24, no. 3 (2017): 444–47. http://dx.doi.org/10.1111/rirt.12966.

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41

Taygerly, Joshua P., Michael P. DeMartino, Brian T. Jones, et al. "Abstract 5750: Discovery of GSK4418959 (IDE275): A novel, non-covalent, reversible Werner Helicase inhibitor and a new potential therapeutic for the treatment of MSI-H cancers." Cancer Research 85, no. 8_Supplement_1 (2025): 5750. https://doi.org/10.1158/1538-7445.am2025-5750.

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Recent large-scale genome wide CRISPR screens identified Werner (WRN) Helicase as uniquely essential to cell survival specifically in the microsatellite instability-high (MSI-H) cancer setting. This synthetic lethal relationship elevated WRN as an attractive precision therapeutic target for the treatment of MSI-H cancers, irrespective of tumor type. High-throughput screening identified a hit characterized by low potency inhibition of ATPase function. This poster describes the systematic optimization of this hit resulting in the discovery of clinical candidate GSK4418959, a novel, potent and se

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Rao, Yanhua, Gabriele Picco, Diana M. Munoz, et al. "Abstract 6393: Patient selection, target engagement and pharmacodynamic markers of WRN inhibitor GSK4418959 (IDE275)." Cancer Research 85, no. 8_Supplement_1 (2025): 6393. https://doi.org/10.1158/1538-7445.am2025-6393.

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Abstract GSK4418959 (IDE275) is a clinical-stage WRN helicase inhibitor designed to treat MSI-H cancer. This compound phenocopies WRN genetic inactivation, with exquisite MSI-H selectivity in large panel of cell lines. Results from extensive cell line profiling indicate a strong correlation between MSI score and sensitivity to the compound. Interestingly, sensitivity to the compound also correlates with the TA-repeat prevalence of individual cell lines. There appears to be no bias toward specific genetic mutations in the dMMR panel, and the compound's sensitivity is not affected by the driver

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Pype, Katrien. "Pratiques religieuses africaines et médias numériques." Emulations - Revue de sciences sociales, no. 24 (March 16, 2018): 135–44. http://dx.doi.org/10.14428/emulations.024.009.

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Cette série de six articles, tous focalisés sur l’Afrique francophone, traite chacun à leur manière du thème principal de l’usage de l’Internet par des groupes religieux sur le continent africain. Cinq de ces contributions explorent l’usage religieux des médias numériques en Afrique de l’Ouest alors que la dernière se concentre sur l’Afrique centrale. Nous en tirons une vue d’ensemble équilibrée sur diverses communautés religieuses telles le Hibut-Tarqiyyah du Sénégal, des églises chrétiennes de Ouagadougou, des chrétiens de la République démocratique du Congo, des fidèles camerounais du paste

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DiMaggio, Matt, Jesse Von Linden, Joshua Patterson, and Cortney Ohs. "Aquaculture Applications of the Family Gobiidae." EDIS 2020, no. 3 (2020): 7. http://dx.doi.org/10.32473/edis-fa226-2020.

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       Marine ornamental fish production is still in its infancy compared with its freshwater counterpart. About 1,800 wild-caught fish species are imported into the United States each year, clear proof of the need for the expansion of marine ornamental production to include new species and families of fish. The family Gobiidae is the fourth most imported family of marine ornamental fish. Gobies can be easily housed with a variety of other species of fish. Several have qualities that lend themselves to aquarium life. Some clean other fish and others si

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Gee, Marvin H., Joshua Goldsmith, Ryan Stafford, et al. "Abstract 3508: Breaking down solid tumor barriers with a bispecific T cell engager against a novel pHLA target." Cancer Research 85, no. 8_Supplement_1 (2025): 3508. https://doi.org/10.1158/1538-7445.am2025-3508.

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Abstract Recent clinical results show the ability to target intracellular proteins through peptides presented by human leukocyte antigen (pHLA), opening up a unique avenue to targets inaccessible to conventional biologics. Bispecific T cell engagers are an effective therapeutic modality to redirect T cell immune responses towards tumors. However, there is still significant unmet need in a number of solid tumor indications with limited treatment options and few pHLA targets. Using a high-throughput discovery platform utilizing experimental screening and machine learning approaches to map patien

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Beck, Jonathan E. "Crossing the Jordan: Diachrony Versus Synchrony in the Book of Joshua by Eun-Woo Lee, Bloomsbury T&T Clark, 2013 (ISBN 978-0-567-38067-8), 237 pp., hb £60." Reviews in Religion & Theology 21, no. 1 (2014): 68–70. http://dx.doi.org/10.1111/rirt.12268.

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Ng, Mark, Emily Zygiel, Alexander McQuown, et al. "Abstract 3521: A novel T cell engager targeting HLA-A02:01 TP53-R175H for cancer immunotherapy." Cancer Research 85, no. 8_Supplement_1 (2025): 3521. https://doi.org/10.1158/1538-7445.am2025-3521.

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Background: The tumor suppressor protein p53 (TP53) plays a pivotal role in preventing tumor formation by inducing cell cycle arrest and apoptosis in response to DNA damage. However, TP53 mutations are prevalent across various cancer types, and these mutations not only result in loss of tumor suppressive functions but also confer gain-of-function properties that drive oncogenesis. Among these mutations, HLA-A0201 TP53-R175H represents the largest TP53 population with &gt;34,000 cases per year in the US and EU across all solid tumor indications, with no therapies explicitly targeting this m

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Freedman, Joshua, Georgia Stevens, Julie Julie Hoong та ін. "Abstract LB062: ADT3_A potential first-in-class Vδ1-engager for in situ activation of Vδ1 γδ T cells and enhanced cytotoxicity towards solid tumors". Cancer Research 84, № 7_Supplement (2024): LB062. http://dx.doi.org/10.1158/1538-7445.am2024-lb062.

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Abstract Gamma delta (γδ) T cells are crucial in stress surveillance for infections and cancer. Studies have shown that tumour-infiltrating γδ T cells are a positive prognostic factor in cancer therapy. While γδ T cells share many characteristics with their αβ T cell counterpart, such as cytotoxic effector functions, they express a distinct TCR that is composed of a γ and a δ chain, belong to the HLA-class-I unrestricted immune cell subset with the ability to discriminate and specifically kill tumor cells via recognition of tumor stress ligands. Clinical trials using Vδ1 γδ T cell therapies ha

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Revach, Or-Yam, Angelina Cicerchia, Ofir Shorer, et al. "Abstract B034: Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants." Cancer Research 85, no. 5_Supplement (2025): B034. https://doi.org/10.1158/1538-7445.genfunc25-b034.

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Abstract T cell exhaustion is a major driver of immune checkpoint blockade (ICB) resistance and clinically effective strategies to prevent or reverse T cell exhaustion to restore ICB sensitivity are lacking. CD38, an ecto-enzyme involved in NAD+ catabolism, is highly expressed in exhausted CD8+ T cells in human melanoma, yet its role in T cell exhaustion remains to be elucidated. Here we show that CD38+CD8+ T cells are enriched during tumor progression and following unsuccessful ICB treatment and are strongly associated with ICB resistance in melanoma. Chronic TCR activation and type I interfe

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Zhao, Shushu, Yeqing Chen, Pratik S. Bhojnagarwala, et al. "Abstract LB213: Heterogeneous expression of IL13Ra2 in melanoma patient-derived xenograft models and targeting with bispecific T cell engager for melanoma therapy." Cancer Research 85, no. 8_Supplement_2 (2025): LB213. https://doi.org/10.1158/1538-7445.am2025-lb213.

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Abstract Melanoma is a highly aggressive skin cancer, especially diagnosed in advanced stages. While current treatments such as targeted therapies and immunotherapies have made promising progress, challenges like drug resistance and limited effectiveness in some patients persist. Therefore, ongoing development of novel therapies, particularly for late-stage melanoma, is crucial. In this study, we explored the expression of interleukin-13 receptor subunit alpha-2 (IL13Rα2) in melanoma patient-derived xenograft (PDX) models. Our findings revealed heterogeneous expression of IL13Rα2, particularly

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