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1

Bousmah, Marwân-al-Qays, Pathé Diakhaté, Grâce à. Dieu Toulao, Jean-Yves Le Hesran, and Richard Lalou. "Effects of a free health insurance programme for the poor on health service utilisation and financial protection in Senegal." BMJ Global Health 7, Suppl 9 (December 2022): e009977. http://dx.doi.org/10.1136/bmjgh-2022-009977.

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IntroductionImplemented in 2013 in Senegal, theProgramme National de Bourses de Sécurité Familiale(PNBSF) is a national cash transfer programme for poor households. Besides reducing household poverty and encouraging children’s school attendance, an objective of the PNBSF is to expand health coverage by guaranteeing free enrolment in community-based health insurance (CBHI) schemes. In this paper, we provide the first assessment of the PNBSF free health insurance programme on health service utilisation and health-related financial protection.MethodsWe collected household-level and individual-level cross-sectional data on health insurance in 2019–2020 within the Niakhar Population Observatory in rural Senegal. We conducted a series of descriptive analyses to fully describe the application of the PNBSF programme in terms of health coverage. We then used multivariate logistic and Poisson regression models within an inverse probability weighting framework to estimate the effect of being registered in a CBHI through the PNBSF—as compared with having no health insurance or having voluntarily enrolled in a CBHI scheme—on a series of outcomes.ResultsWith the exception of health facility deliveries, which were favoured by free health insurance, the PNBSF did not reduce the unmet need for healthcare or the health-related financial risk. It did not increase individuals’ health service utilisation in case of health problems, did not increase the number of antenatal care visits and did not protect households against the risk of forgoing medical care and of catastrophic health expenditure.ConclusionWe found limited effects of the PNBSF free health insurance on health service utilisation and health-related financial protection, although these failures were not necessarily due to the provision of free health insurance per se. Our results point to both implementation failures and limited programme outcomes. Greater commitment from the state is needed, particularly through strategies to reduce barriers to accessing covered healthcare.
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Kanyangarara, Mufaro, Laetitia Douillot, Gilles Pison, Cheikh Tidiane Ndiaye, Valerie Delaunay, and Stephane Helleringer. "Tracing Long- and Short-term Migrants for Participation in Demographic and Epidemiological Studies: Evidence from Senegal." Field Methods 32, no. 1 (November 6, 2019): 38–57. http://dx.doi.org/10.1177/1525822x19879892.

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Migration of participants in demographic and epidemiological studies results in missing data. One approach to reduce resulting losses in statistical power and potential biases is to follow up migrants at their new residence. We describe the follow-up of migrants who were eligible for participation in a trial of a new questionnaire to measure adult mortality in Niakhar, Senegal. We conducted a short inquiry in the migrant’s last known household to obtain contact information and then attempted to contact and interview 661 migrants who resided in Dakar, Mbour, and rural areas close to Niakhar. About two-thirds of migrants were successfully enrolled in the study. Having a contact phone number and knowing the name of the head of compound at destination increased the likelihood of successful enrollment. Following up migrants in demographic studies is feasible in low- and middle-income countries, including long-term migrants who have not been contacted for extended periods of time.
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Ndonky, Alphousseyni, Mouhamadou Moustapha Mbacké Ndour, Ibrahima Ndiaye, Richard Lalou, and Cheikh Tine. "Mapping Rural Mobility in the Niakhar Area (Fatick Region, Senegal)." Journal of Geographic Information System 13, no. 01 (2021): 65–82. http://dx.doi.org/10.4236/jgis.2021.131005.

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Ronsmans, C., M. Khlat, B. Kodio, M. Ba, L. De Bernis, and JF Etard. "Evidence for a ‘healthy pregnant woman effect’ in Niakhar, Senegal?" International Journal of Epidemiology 30, no. 3 (June 2001): 467–73. http://dx.doi.org/10.1093/ije/30.3.467.

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Paupy, Christophe, Cécile Brengues, Ousmane Ndiath, Céline Toty, Jean-Pierre Hervé, and Frédéric Simard. "Morphological and genetic variability within Aedes aegypti in Niakhar, Senegal." Infection, Genetics and Evolution 10, no. 4 (May 2010): 473–80. http://dx.doi.org/10.1016/j.meegid.2010.03.001.

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Potter, Gail E., Jimmy Wong, Jonathan Sugimoto, Aldiouma Diallo, John C. Victor, Kathleen Neuzil, and M. Elizabeth Halloran. "Networks of face-to-face social contacts in Niakhar, Senegal." PLOS ONE 14, no. 8 (August 6, 2019): e0220443. http://dx.doi.org/10.1371/journal.pone.0220443.

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Goodburn, E. "Commentary: Evidence for a ‘healthy pregnant woman effect’ in Niakhar, Senegal?" International Journal of Epidemiology 30, no. 3 (June 2001): 474–75. http://dx.doi.org/10.1093/ije/30.3.474.

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Garenne, Michel, Mark Myatt, Tanya Khara, Carmel Dolan, and André Briend. "Concurrent wasting and stunting among under‐five children in Niakhar, Senegal." Maternal & Child Nutrition 15, no. 2 (November 25, 2018): e12736. http://dx.doi.org/10.1111/mcn.12736.

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Sandberg, John, Steven Rytina, Valérie Delaunay, and Adama S. Marra. "Social learning about levels of perinatal and infant mortality in Niakhar, Senegal." Social Networks 34, no. 2 (May 2012): 264–74. http://dx.doi.org/10.1016/j.socnet.2012.01.001.

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Garenne, Michel, Bernard Maire, Olivier Fontaine, and André Briend. "Distributions of Mortality Risk Attributable to Low Nutritional Status in Niakhar, Senegal." Journal of Nutrition 136, no. 11 (November 1, 2006): 2893–900. http://dx.doi.org/10.1093/jn/136.11.2893.

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Garenne, Michel, Douladel Willie, Bernard Maire, Olivier Fontaine, Roger Eeckels, André Briend, and Jan Van den Broeck. "Incidence and duration of severe wasting in two African populations." Public Health Nutrition 12, no. 11 (March 3, 2009): 1974–82. http://dx.doi.org/10.1017/s1368980009004972.

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AbstractObjectiveThe present study aimed to compare two situations of endemic malnutrition among <5-year-old African children and to estimate the incidence, the duration and the case fatality of severe wasting episodes.DesignSecondary analysis of longitudinal studies, conducted several years ago, which allowed incidence and duration to be calculated from transition rates. The first site was Niakhar in Senegal, an area under demographic surveillance, where we followed a cohort of children in 1983–5. The second site was Bwamanda in the Democratic Republic of Congo, where we followed a cohort of children in 1989–92. Both studies enrolled about 5000 children, who were followed by routine visits and systematic anthropometric assessment, every 6 months in the first case and every 3 months in the second case.ResultsNiakhar had less stunting, more wasting and higher death rates than Bwamanda. Differences in cause-specific mortality included more diarrhoeal diseases, more marasmus, but less malaria and severe anaemia in Niakhar. Severe wasting had a higher incidence, a higher prevalence and a more marked age profile in Niakhar. However, despite the differences, the estimated mean durations of episodes of severe wasting, calculated by multi-state life table, were similar in the two studies (7·5 months). Noteworthy were the differences in the prevalence and incidence of severe wasting depending on the anthropometric indicator (weight-for-height Z-score ≤–3.0 or mid upper-arm circumference <110 mm) and the reference system (National Center for Health Statistics 1977, Centers for Disease Control and Prevention 2000 or Multicentre Growth Reference Study 2006).ConclusionsSevere wasting appeared as one of the leading cause of death among under-fives: it had a high incidence (about 2 % per child-semester), long duration of episodes and high case fatality rates (6 to 12 %).
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Gaye, Papa Mouhamadou, Souleymane Doucoure, Bruno Senghor, Babacar Faye, Ndiaw Goumballa, Mbacké Sembène, Coralie L’Ollivier, et al. "Bulinus senegalensis and Bulinus umbilicatus Snail Infestations by the Schistosoma haematobium Group in Niakhar, Senegal." Pathogens 10, no. 7 (July 8, 2021): 860. http://dx.doi.org/10.3390/pathogens10070860.

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Thorough knowledge of the dynamics of Bulinus spp. infestation could help to control the spread of schistosomiasis. This study describes the spatio-temporal dynamics of B. senegalensis and B. umbilicatus infestation by the Schistosoma haematobium group of blood flukes in Niakhar, Senegal. Molecular identification of the S. haematobium group was performed by real-time PCR, targeting the Dra 1 gene in 810 samples of Bulinus spp. collected during the schistosomiasis transmission season in 2013. In addition to Dra 1 PCR, a rapid diagnostic-PCR was performed on a sub-group of 43 snails to discriminate S. haematobium, S. bovis, and S. mattheei. Out of 810 snails, 236 (29.1%) were positive for Dra 1 based on the PCR, including 96.2% and 3.8% of B. senegalensis and B. umbilicatus, respectively. Among the sub-group, 16 samples were confirmed to be S. haematobium while one was identified as a mixture of S. haematobium and S. bovis. Snails infestations were detected in all villages sampled and infestation rates ranged from 15.38% to 42.11%. The prevalence of infestation was higher in the north (33.47%) compared to the south (25.74%). Snail populations infestations appear early in the rainy season, with a peak in the middle of the season, and then a decline towards the end of the rainy season. Molecular techniques showed, for the first time, the presence of S. bovis in the Bulinus spp. population of Niakhar. The heterogeneity of snail infestations at the village level must be taken into account in mass treatment strategies. Further studies should help to improve the characterizations of the schistosome population.
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Ndiaye, El Hadji Ibrahima, Fatou Samba Diouf, Mady Ndiaye, Hubert Bassene, Didier Raoult, Cheikh Sokhna, Philippe Parola, and Georges Diatta. "Tick-borne relapsing fever Borreliosis, a major public health problem overlooked in Senegal." PLOS Neglected Tropical Diseases 15, no. 4 (April 22, 2021): e0009184. http://dx.doi.org/10.1371/journal.pntd.0009184.

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Background Tick-borne relapsing fever (TBRF) is the most common vector-borne bacterial disease in humans in West Africa. It is frequently clinically confused with malaria. Our study aims to determine, on a micro-geographic scale, the conditions for the maintenance and spread of TBRF in the Niakhar district of Senegal. Methodology/Principal findings We conducted clinical, entomological and animal reservoir investigations. Field surveys were carried out in order to investigate the presence of Ornithodoros sonrai vector ticks and to detect Borrelia spp. by qPCR using the 16S rRNA and glpQ genes, respectively. Micromammal trapping series were carried out inside homes and Borrelia infection was detected using brain tissue qPCR. Capillary blood samples from febrile patients were also tested for Borrelia using qPCR. More than 97% (40/41) of the villages surveyed were infested with O. sonrai ticks. The prevalence of Borrelia spp. infections in ticks was 13% (116/910), and over 73% (85/116) were positively confirmed as being Borrelia crocidurae. Borreliosis cases accounted for 12% (94/800) of episodes of fever and all age groups were infected, with children and young people between the ages of 8–14 and 22–28 being the most infected by the disease (16% and 18.4%). TBRF cases occurred in all seasons, with a peak in August. In two species of small rodents that were found to be infected (Arvicanthis niloticus, Mus musculus), the proportion of Borrelia infection was 17.5% (10/57), and the highest prevalence of infection (40.9%, 9/22) was observed in A. niloticus. Conclusion/Significance Our study indicates that TBRF is an endemic disease in the Niakhar district, where children and young people are the most infected. Arvicanthis niloticus and O. sonrai ticks are massively present and appear to be the main epidemiological reservoirs causing its extensive spread to humans.
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Bennett, J. "Seroconversions in unvaccinated infants: further evidence for subclinical measles from vaccine trials in Niakhar, Senegal." International Journal of Epidemiology 28, no. 1 (February 1, 1999): 147–51. http://dx.doi.org/10.1093/ije/28.1.147.

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Etard, J. F. "Childhood mortality and probable causes of death using verbal autopsy in Niakhar, Senegal, 1989-2000." International Journal of Epidemiology 33, no. 6 (December 1, 2004): 1286–92. http://dx.doi.org/10.1093/ije/dyh259.

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Garenne, Michel, and Jeroen van Ginneken. "Comparison of retrospective surveys with a longitudinal follow-up in Senegal: SFS, DHS and Niakhar." European Journal of Population / Revue européenne de Démographie 10, no. 3 (September 1994): 203–21. http://dx.doi.org/10.1007/bf01265302.

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Pison, Gilles, Bruno Masquelier, Almamy Malick Kante, Cheikh Tidiane Ndiaye, Laetitia Douillot, Géraldine Duthé, Cheikh Sokhna, Valérie Delaunay, and Stéphane Helleringer. "Estimating mortality from external causes using data from retrospective surveys: A validation study in Niakhar (Senegal)." Demographic Research 38 (March 7, 2018): 879–96. http://dx.doi.org/10.4054/demres.2018.38.32.

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18

Munier, A., A. Diallo, and J. P. Chippaux. "Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992–2004)." Transactions of the Royal Society of Tropical Medicine and Hygiene 103, no. 12 (December 2009): 1288–90. http://dx.doi.org/10.1016/j.trstmh.2009.03.017.

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Garenne, Michel, Bernard Maire, Olivier Fontaine, and André Briend. "Adequacy of child anthropometric indicators for measuring nutritional stress at population level: a study from Niakhar, Senegal." Public Health Nutrition 16, no. 9 (October 9, 2012): 1533–39. http://dx.doi.org/10.1017/s136898001200448x.

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AbstractObjectiveTo compare the responsiveness of different anthropometric indicators for measuring nutritional stress among children in developing countries.DesignGrowth was studied within 6-month intervals in a rural Senegalese community during one dry and two rainy (hungry) seasons. Responsiveness was defined as the change divided by the standard deviation of each anthropometric indicator. Contrast was defined as the difference in responsiveness between dry and rainy seasons.SettingThe study was conducted in Niakhar, a rural area of Senegal under demographic surveillance, with contrasted food and morbidity situations between rainy and dry seasons.SubjectsSome 5000 children under 5 years of age were monitored at 6-month intervals in 1983–1984. The present analysis was carried out on a sub-sample of children aged 6–23 months with complete measures, totalling 2803 children-intervals.ResultsIn both univariate and multivariate analysis, mid-upper arm circumference was found to be more responsive to nutritional stress than the commonly used weight-for-height Z-score (contrast = −0·64 for mid-upper arm circumference v. −0·53 for weight-for-height Z-score). Other discriminant indicators were: muscle circumference, weight-for-height, BMI and triceps skinfold. Height, head circumference and subscapular skinfold had no discriminating power for measuring the net effect of nutritional stress during the rainy season.ConclusionsThe use of mid-upper arm circumference for assessing nutritional stress in community surveys should be considered and preferred to other nutritional indicators. Strict standardization procedures for measuring mid-upper arm circumference are required for optimal use.
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Faye, Mbaye, Abdoulaye Dème, and Abdou Kâ Diongue. "Modeling the relationship between temperature and mortality : a case study in SENEGAL." African Journal of Applied Statistics 8, no. 1 (January 1, 2021): 1073–100. http://dx.doi.org/10.16929/ajas/2021.1073.258.

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In this paper, we have used the Generalized Additive Model (GAM) to investigate the relationships between high temperature and daily number of deaths in Niakhar, a Sehalian-Sudanese climate in central Senegal. Daily data on number of deaths and meteorological variables over the period of 1983-2013 were considered. Descriptive statistics show that, over the study period, the total of non-accidental deaths were 12,798, among which we notice that 490 persons (3.83%) died of cardiovascular disease, 1,015 persons (7.93%) died of respiratory disease, 3,970 persons (31.02%) died of certain infectious and parasitic diseases, and 224 persons (1.75%) died of nervous system disease From the GAM model, we observe that high temperature significantly increased the relative risk (RR)Indeed, relative risk of deaths due to cardiovascular disease is 1.034 with a 95% confidence intervals (CI) 1.025 to 1.044, while it is 1.030 with a 95% CI 1.026 to 1.033 for certain infectious and parasitic disease. For respiratory disease, the RR is 1.012 with a 95% CI 1.007 to 1.017, and for nervous system disease, the relative risk is 1.034 with 95% CI 1.026 to 1.043.
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Faye, Mbaye, Abdoulaye Dème, and Abdou Kâ Diongue. "Modeling the relationship between temperature and mortality : a case study in SENEGAL." African Journal of Applied Statistics 8, no. 1 (January 1, 2021): 1473–96. http://dx.doi.org/10.16929/ajas/2021.1473.258.

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In this paper, we have used the Generalized Additive Model (GAM) to investigate the relationships between high temperature and daily number of deaths in Niakhar, a Sehalian-Sudanese climate in central Senegal. Daily data on number of deaths and meteorological variables over the period of 1983-2013 were considered. Descriptive statistics show that, over the study period, the total of non-accidental deaths were 12,798, among which we notice that 490 persons (3.83%) died of cardiovascular disease, 1,015 persons (7.93%) died of respiratory disease, 3,970 persons (31.02%) died of certain infectious and parasitic diseases, and 224 persons (1.75%) died of nervous system disease From the GAM model, we observe that high temperature significantly increased the relative risk (RR)Indeed, relative risk of deaths due to cardiovascular disease is 1.034 with a 95% confidence intervals (CI) 1.025 to 1.044, while it is 1.030 with a 95% CI 1.026 to 1.033 for certain infectious and parasitic disease. For respiratory disease, the RR is 1.012 with a 95% CI 1.007 to 1.017, and for nervous system disease, the relative risk is 1.034 with 95% CI 1.026 to 1.043.
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Senghor, Bruno, Aldiouma Diallo, Seydou N. Sylla, Souleymane Doucouré, Mamadou O. Ndiath, Lobna Gaayeb, Félicité F. Djuikwo-Teukeng, Cheikh T. Bâ, and Cheikh Sokhna. "Prevalence and intensity of urinary schistosomiasis among school children in the district of Niakhar, region of Fatick, Senegal." Parasites & Vectors 7, no. 1 (2014): 5. http://dx.doi.org/10.1186/1756-3305-7-5.

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FRANCKEL, AURÉLIEN, and RICHARD LALOU. "HEALTH-SEEKING BEHAVIOUR FOR CHILDHOOD MALARIA: HOUSEHOLD DYNAMICS IN RURAL SENEGAL." Journal of Biosocial Science 41, no. 1 (January 2009): 1–19. http://dx.doi.org/10.1017/s0021932008002885.

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SummaryResearch on health care behaviour in sub-Saharan Africa usually considers the mother as the reference in the household when a child is sick. The study of health care management within the family is a key issue for understanding therapeutic rationales. This study was conducted in the region of Fatick in Senegal among 902 children with malaria-related fever. The data were taken from a retrospective quantitative survey conducted in all compounds of the DSS (Demographic Surveillance Site) of Niakhar. The results show that child care-taking is fundamentally a collective process: in 70·9% of out-of-home resorts, the treatment decision was collective. The health care process of 68·1% of morbid episodes involved several individuals. The involvement of the mother, the father and other relatives in the collective management of health care followed different logics. Each care-giver had a specific and complementary function depending on gender norms, intergenerational relations and characteristics of the family unit. Family management of illness aims at optimizing financial and human resources given the economic, logistical and social constraints on health care. Nevertheless, collective management also favoured home-based care, prevented good treatment compliance and delayed the resort to health facilities. These results suggest that health education campaigns should focus on an early involvement of fathers in health care-giving and also on the strengthening of the autonomy of mothers. Mothers’ empowerment should give women more autonomy in their child’s treatment choice. Lastly, there is a need to develop community health facilities and establish shared funding at the community level.
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Périères, Lauren, Fabienne Marcellin, Gora Lo, Camelia Protopopescu, El Ba, Marion Coste, Coumba Touré Kane, et al. "Hepatitis B Vaccination in Senegalese Children: Coverage, Timeliness, and Sociodemographic Determinants of Non-Adherence to Immunisation Schedules (ANRS 12356 AmBASS Survey)." Vaccines 9, no. 5 (May 15, 2021): 510. http://dx.doi.org/10.3390/vaccines9050510.

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Detailed knowledge about hepatitis B virus (HBV) vaccination coverage and timeliness for sub-Saharan Africa is scarce. We used data from a community-based cross-sectional survey conducted in 2018–2019 in the area of Niakhar, Senegal, to estimate coverage, timeliness, and factors associated with non-adherence to the World Health Organisation-recommended vaccination schedules in children born in 2016 (year of the birth dose (BD) introduction in Senegal) and 2017–2018. Vaccination status was assessed from vaccination cards, surveillance data, and healthcare post vaccination records. Among 241 children with available data, for 2016 and 2017–2018, respectively, 31.0% and 66.8% received the BD within 24 h of birth (BD schedule), and 24.3% and 53.7% received the BD plus at least two pentavalent vaccine doses within the recommended timeframes (three-dose schedule). In logistic regression models, home birth, dry season birth, and birth in 2016 were all associated with non-adherence to the recommended BD and three-dose schedules. Living over three kilometres from the nearest healthcare post, being the firstborn, and living in an agriculturally poorer household were only associated with non-adherence to the three-dose schedule. The substantial proportion of children not vaccinated according to recommended schedules highlights the importance of considering vaccination timeliness when evaluating vaccination programme effectiveness. Outreach vaccination activities and incentives to bring children born at home to healthcare facilities within 24 h of birth, must be strengthened to improve timely HBV vaccination.
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Helleringer, Stéphane, Gilles Pison, Bruno Masquelier, Almamy Malick Kanté, Laetitia Douillot, Géraldine Duthé, Cheikh Sokhna, and Valérie Delaunay. "Improving the Quality of Adult Mortality Data Collected in Demographic Surveys: Validation Study of a New Siblings' Survival Questionnaire in Niakhar, Senegal." PLoS Medicine 11, no. 5 (May 27, 2014): e1001652. http://dx.doi.org/10.1371/journal.pmed.1001652.

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Coste, Marion, Mouhamed Ahmed Badji, Aldiouma Diallo, Marion Mora, Sylvie Boyer, and Jennifer J. Prah. "Applying the health capability profile to empirically study chronic hepatitis B in rural Senegal: a social justice mixed-methods study protocol." BMJ Open 12, no. 4 (April 2022): e055957. http://dx.doi.org/10.1136/bmjopen-2021-055957.

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IntroductionDespite the early implementation of hepatitis B vaccination and the ongoing decentralisation of chronic hepatitis B (CHB) care, over 10% of the Senegalese adult population lives with CHB and liver cancer remains a main cause of death. Investigating factors associated with CHB infection, prevention of CHB-related morbidity, and prevention and treatment of mortality secondary to CHB calls for a holistic and multidimensional approach. This paper presents the adaptation of the health capability profile (HCP) to a specific epidemiological issue and empirical setting: it seeks to identify and analyse inter-related abilities and conditions (health capabilities) in relation to the CHB epidemic in the rural area of Niakhar, Senegal.Methods and analysisThis ongoing study relies on a sequential social justice mixed-methods design. The HCP is comprehensively adapted to CHB in rural Senegal and guides the design and conduct of the study. Objective and subjective data are collected at the individual level following a mixed-methods explanatory core design. The quantitative module, embedded in the ANRS12356 AmBASS cross-sectional survey (exhaustive sampling), is used to select a purposeful sampling of participants invited for one-on-one qualitative interviews. Additional data are collected at the institutional and community level through health facility surveys and an ethnography (in-depth interviews) of local and national CHB stakeholders. Data analysis adopts a synergistic approach to produce a multilayered analysis of individual HCPs and crosscutting analysis of the 15 health capabilities. The data integration strategy relies on a mixed-methods convergent core design, and will use 0–100 health capability scores as well as flow diagrams to measure and characterise levels of development and interactions among health capabilities, respectively.Ethics and disseminationThis study was approved by Senegalese and French authorities. Results dissemination through local workshops and scientific publications aim at fuelling effective policy change towards CHB-related health capability.
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Coste, Marion, Maëlle De Sèze, Aldiouma Diallo, Maria Patrizia Carrieri, Fabienne Marcellin, and Sylvie Boyer. "Burden and impacts of chronic hepatitis B infection in rural Senegal: study protocol of a cross-sectional survey in the area of Niakhar (AmBASS ANRS 12356)." BMJ Open 9, no. 7 (July 2019): e030211. http://dx.doi.org/10.1136/bmjopen-2019-030211.

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IntroductionThough Senegal has one of the highest estimated prevalence rates of chronic hepatitis B virus (HBV) infection worldwide, epidemiological data in the general population are lacking and consequences of the infection remain undocumented. The ANRS-12356 AmBASS study aims at evaluating the health and socioeconomic burden of chronic HBV infection at the individual, household and population level. Its specific objectives are (1) to document the epidemiology of chronic HBV infection, including prevalence and risk factors; (2) to assess the acceptability of home-based testing and first clinic visit; (3) to investigate the repercussions of chronic HBV infection on living conditions; and (4) to estimate the public health impact of chronic HBV infection at the population level and the feasibility of a decentralised model of HBV test and treat.Methods and analysisThis multidisciplinary cross-sectional survey includes a twofold data collection: (1) home-based screening using dried blood spot (DBS) sampling and collection of sociodemographic, economic and behavioural data, and (2) additional clinical and biological data collection in chronic HBV carriers at the first clinic visit. The prevalence of chronic HBV infection will be estimated in the general population and in key subgroups. Risk factors for HBV acquisition in children will be explored using case-control analysis. HBV burden will be assessed through comparisons of health and economic outcomes between households affected by the disease versus non-affected households. Last, an economic evaluation will assess costs and health benefits of scaling-up HBV care.Ethics and disseminationThis study was approved by the Senegalese National Ethical Committee for Research in Health, and received authorisation from the Senegalese Ministry of Health and the French Commission on Information Technology and Liberties (Senegalese Protocol Number: SEN17/15). The study results will be presented in peer-review journals, international conferences and at a workshop with national stakeholders in order to contribute to the design of programmes to address the HBV pandemic.Trial registration numberNCT03215732; Pre-results.
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Garnier, Denis, Kirsten B. Simondon, Thierry Hoarau, and Eric Benefice. "Impact of the health and living conditions of migrant and non-migrant Senegalese adolescent girls on their nutritional status and growth." Public Health Nutrition 6, no. 6 (September 2003): 535–47. http://dx.doi.org/10.1079/phn2003463.

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AbstractObjective:To describe the living conditions of Senegalese adolescent girls according to their migration status, and to define the main socio-economic and biological determinants of their nutritional and growth status.Design:Health and living conditions, sexual maturation, and nutritional and growth status of adolescent girls were determined within the framework of a longitudinal study on growth.Settings:The capital city of Senegal (Dakar) and a rural community (Niakhar), 120 km south-east of Dakar.Subjects:Three hundred and thirty-one girls, 14.5–16.6 years of age, were recruited from the same villages. Thirty-six per cent of the sample remained in the villages to attend school and/or to help with household subsistence tasks (non-migrants). The remaining (64%) migrated to cities to work as maids (migrants) and lived in two different socio-economic environments: at the home of a guardian during the night and in the house of the employer during the daytime.Results:Family rural environment and guardian and employer urban environments were socio-economically different (P < 0.001). Living conditions in urban areas were better than in rural areas and the employer's environment was socio-economically more favourable. Migrants had more advanced sexual maturation and higher body mass index (BMI), fat mass index (FMI) and mid-upper arm circumference than non-migrants. However, migrants were smaller than non-migrants. BMI, FMI and weight-for-age were related to socio-economic levels and duration of migration. Schooling was positively related to height and negatively related to BMI.Conclusions:Migrants enjoyed better living conditions than non-migrants. This could be partly due to the better socio-economic environment of the employer. It was associated with earlier puberty and better nutritional status, but not with a better growth.
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Djomo, Patrick Nguipdop, Sylvie Nyafouna Diop, Ndeye Licka Dieye, Amélé-Nyedzie Wotodjo, Min Kim, Elhadji Ba, Javier Guitian, and Punam Mangtani. "1134Seroprevalence and Risk Factors of Coxiella burnetti infection in the general population of Senegal." International Journal of Epidemiology 50, Supplement_1 (September 1, 2021). http://dx.doi.org/10.1093/ije/dyab168.480.

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Abstract Background Coxiella burnetti, the causal agent of Q-fever, contributes to aetiologies of fevers of unknown origin (FUO) in West Africa. We compared its seroprevalence between Dakar, the largest urban centre in Senegal, and Niakhar, a rural area, and investigated the association to contacts with livestock and dairy products consumption. Methods Large cross-sectional surveys; households randomly selected using a two-stage cluster sampling. Within households, 1-2 participants were randomly selected using a Kish grid. A small blood sample was collected to detect phase 1 and 2 Coxiella burnetti IgG using ELISA, and a questionnaire was administered. Random effect logistic regression models were used to measure the association with risk factors. Results Overall, 2102 participants recruited in Dakar and 1156 in Niakhar. The prevalence of C. burnetti was high in both settings, but higher in rural Niakhar (37%) than urban Dakar (30%), even after adjusting for age, sex and socio-economic status (difference=7%; 95%CI [1.1% to 13%]; p = 0.02). In Dakar, ownership of sheep was associated with greater risk (OR = 1.26; 95%CI[1.00-1.59]; p = 0.048). Livestock contact was associated with higher risk in rural areas, but not in urban areas (helping cattle’s parturition (OR = 2.10; 95%CI [1.38-3.22]; p &lt; 0.01 and abortion (OR = 1.95; 95%CI[1.18-3.23]; p = 0.009). There was no association between dairy products’ consumption and Q-fever in both settings. Conclusions The high seroprevalence in urban and rural settings suggest that Q-fever should be seriously considered by clinicians when investigating fevers in both settings. The observed association with livestock contact is consistent with the lack of use of personal protection equipment. Key messages Clinicians should consider Q-fever among differential diagnosis when investigating non-specific fevers in West Africa.
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30

Ndiaye, El Hadji Ibrahima, Georges Diatta, Adama Zan Diarra, Jean Michel Berenger, Hubert Bassene, Oleg Mediannikov, Charles Bouganali, Cheikh Sokhna, and Philippe Parola. "Morphological, Molecular and MALDI-TOF MS Identification of Bedbugs and Associated Wolbachia Species in Rural Senegal." Journal of Medical Entomology, March 14, 2022. http://dx.doi.org/10.1093/jme/tjac019.

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Abstract Bed bugs are known to carry several microorganisms. The purpose of this study was to assess the prevalence of bed bug infestation in two rural areas of Senegal and determine the species present in the population. A screening was conducted to detect some arthropod associated pathogenic bacteria in bed bugs and to evaluate the prevalence of endosymbiont carriage. One survey took place in 17 villages in Niakhar and two surveys in Dielmo and Ndiop and surroundings area in the same 20 villages. Bed bugs collected were identified morphologically and by MALDI-TOF MS tools. Microorganisms screening was performed by qPCR and confirmed by sequencing. During the survey in the Niakhar region, only one household 1/255 (0.4%) in the village of Ngayokhem was found infested by bed bugs. In a monitoring survey of the surroundings of Dielmo and Ndiop area, high prevalence was found during the two rounds of surveys in 65/314 (21%) in 16/20 villages (January–March) and 93/351 (26%) in 19/20 villages (December). All bed bugs were morphologically identified as the species Cimex hemipterus, of which 285/1,637 (17%) were randomly selected for MALDI-TOF MS analysis and bacteria screening. Among the Bacteria tested only Wolbachia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) DNA was found in 248/276 (90%) of the bedbugs. We briefly describe a high level of non-generalized bed bug infestation in rural Senegal and the diversity of Wolbachia strains carried by C. hemipterus. This study opens perspectives for raising household awareness of bed bug infestations and possibilities for appropriate control.
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31

Munier, Aline, Aldiouma Diallo, Adama Marra, Michel Cot, Pascal Arduin, Ousmane Ndiaye, Balla Mbacké Mboup, Barnabé Gning, and Jean-Philippe Chippaux. "Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal." Malaria Journal 8, no. 1 (November 27, 2009). http://dx.doi.org/10.1186/1475-2875-8-270.

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32

Senghor, Bruno, Omar Talla Diaw, Souleymane Doucoure, Mouhamadane Seye, Idrissa Talla, Adiouma Diallo, Cheikh Tidiane Bâ, and Cheikh Sokhna. "Study of the snail intermediate hosts of urogenital schistosomiasis in Niakhar, region of Fatick, West central Senegal." Parasites & Vectors 8, no. 1 (August 7, 2015). http://dx.doi.org/10.1186/s13071-015-1030-z.

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33

Masquelier, Bruno, Mufaro Kanyangarara, Gilles Pison, Almamy Malick Kanté, Cheikh Tidiane Ndiaye, Laetitia Douillot, Géraldine Duthé, Cheikh Sokhna, Valérie Delaunay, and Stéphane Helleringer. "Errors in reported ages and dates in surveys of adult mortality: A record linkage study in Niakhar (Senegal)." Population Studies, January 4, 2021, 1–19. http://dx.doi.org/10.1080/00324728.2020.1854332.

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34

Munier, Aline, Aldiouma Diallo, Michel Cot, Ousmane Ndiaye, Pascal Arduin, and Jean-Philippe Chippaux. "Anti-malarial prescriptions in three health care facilities after the emergence of chloroquine resistance in Niakhar, Senegal (1992–2004)." Malaria Journal 8, no. 1 (April 27, 2009). http://dx.doi.org/10.1186/1475-2875-8-83.

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35

Senghor, Bruno, Bonnie Webster, Tom Pennance, Mariama Sène, Souleymane Doucouré, Doudou Sow, and Cheikh Sokhna. "Molecular characterization of schistosome cercariae and their Bulinus snail hosts from Niakhar, a seasonal transmission focus in central Senegal." Current Research in Parasitology & Vector-Borne Diseases, January 2023, 100114. http://dx.doi.org/10.1016/j.crpvbd.2023.100114.

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36

Perieres, L., M. Coste, S. Ndiour, P. Halfon, C. Sokhna, E. Ba, A. Diallo, and S. Boyer. "Hepatitis B vaccination status and vaccine immune response among children in rural Senegal." European Journal of Public Health 29, Supplement_4 (November 1, 2019). http://dx.doi.org/10.1093/eurpub/ckz185.592.

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Abstract Background Hepatitis B vaccination during childhood is key to reduce the prevalence of Hepatitis B virus (HBV) infection. In Senegal, a highly endemic country, the three-dose hepatitis B vaccine and the birth dose vaccine were introduced in the Expanded Programme on Immunization (EPI) in 2004 and 2016 respectively. This study aimed to determine chronic HBV infection prevalence, hepatitis B vaccination status and vaccine immunity among children in Senegal. Methods A cross-sectional study including HBV screening was conducted at home among children aged 6 months to 15 years (i.e. born after the introduction of the HBV vaccine in the EPI) in the rural zone of Niakhar. Dried Blood Spot (DBS) samples were collected for the detection of HBsAg, anti-HBc Ab and anti-HBs Ab using chemoluminescence. Vaccination status was assessed using information on vaccination cards. Detectable vaccine immunity was defined with an adjusted DBS threshold of DOI≥0.36 IU/mL (corresponding to 10 IU/mL in venous blood sampling). Results Between October and December 2018, 455 children were enrolled. Preliminary results show that 7/455 (1.5%) had been in contact with HBV (positive anti-HBc Ab) and 5/455 (1.1%) had chronic HBV infection (positive HBsAg). Only 161/455 (35.4%) children had a vaccination card available. Among those, 150/161 (93.2%) received at least 3 doses of hepatitis B vaccine, of which 83/150 (55.3%) had detectable vaccine immunity. The proportion of children with detectable vaccine immunity was significantly higher in children &lt;5 years than in children aged 5-9 and 10-15 (72.3% versus 47.3%, p = 0.006 and 72.3% versus 14.3%, p &lt; 0.001). Conclusions Preliminary results suggest a low prevalence of HBV chronic infection among children born after the introduction of HBV vaccination in Senegal. However, detectable vaccine immunity rapidly decreases with age among vaccinated children, signalling a need for further studies on the immune response to HBV vaccination in this context. Key messages HBV chronic infection is low among children born after the introduction of HBV vaccination in Senegal. Further studies on the immune response to HBV vaccination in this context are needed.
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37

Djaogol, T., M. Coste, F. Marcellin, A. Diallo, P. Carrieri, and S. Boyer. "Prenatal care: missed opportunity for HBV prevention in women of childbearing age in rural Senegal." European Journal of Public Health 29, Supplement_4 (November 1, 2019). http://dx.doi.org/10.1093/eurpub/ckz187.124.

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Abstract Background Perinatal transmission of hepatitis B virus (HBV) constitutes an important risk in highly endemic countries including Senegal. Although the prevalence of chronic HBV infection is estimated at 11% in this country, specific data on women of childbearing age are sorely lacking. We described in this study the prevalence of the HBV antigen (HbsAg) in women of childbearing age in rural Senegal, as well as general knowledge on HBV and hepatitis B status awareness. Methods A cross-sectional study including HBV screening was conducted at home in the rural Niakhar area. Chronic HBV infection was determined through HBsAg detection using dried blood spots. Socio-demographic and behavioral data were collected through standardized face-to-face questionnaires. The analyzes included 368 women aged 15-49 (67% married; 65% with at least 1 child) enrolled from October 2018 to March 2019. Results Preliminary results show that 49 women (13%) had positive HBsAg. Only 68 women (18%) have already heard about HBV. Among them, 53% knew that there exists an HBV vaccine and 78%, 75% and 67% correctly answered that HBV can be transmitted through blood contact, childbirth and sexual intercourse, respectively. Among the 233 (63%) women who had already given birth, 76% had attended at least 4 antenatal care sessions and 74% had given birth in a healthcare facility for their last pregnancy. However, only 1% reported to have already been screened for HBV. Main reasons reported for not having been screened were having never heard about this test (80%) and not having been offered screening during antenatal care sessions (10%). Conclusions General knowledge and awareness of HBV status are particularly low in women of childbearing age living in rural Senegal, despite high antenatal care sessions attendance. Given the high prevalence of chronic HBV infection found in this population, it is urgent to ensure systematic HVB screening and to provide adequate information to women during pregnancy. Key messages The prevalence of chronic HBV is high in women of childbearing age in Senegal. National recommendations for women attending antenatal care sessions should include HBV screening and counselling.
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38

Sow, Doudou, Khadime Sylla, Ndeye Marème Dieng, Bruno Senghor, Papa Mouhamadou Gaye, Cheikh B. Fall, Ndiaw Goumballa, et al. "Molecular diagnosis of urogenital schistosomiasis in pre-school children, school-aged children and women of reproductive age at community level in central Senegal." Parasites & Vectors 16, no. 1 (January 31, 2023). http://dx.doi.org/10.1186/s13071-023-05671-x.

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Abstract Background Urogenital schistosomiasis is a major public health concern in sub-Saharan Africa. In Senegal, the disease is endemic in all regions of the country. Recently, WHO strongly recommended including pre-school children and women of reproductive age during a mass drug administration campaign. It is important to describe the burden of the disease in these group at risk using innovative diagnostic tools. This study aimed to assess the use of real-time PCR in the detection of schistosomiasis cases at the community level in a seasonal transmission area. Methods A cross-sectional survey was carried out in Niakhar located in the centre of Senegal. Pre-schoolchildren, school-aged children and female adolescents and adults were invited to participate in the study in April 2018. Urine samples were collected and examined using Hemastix reagent strips, filtration technique and real-time PCR. Schistosoma haematobium was detected, identified by targeting the Dra1 gene. The prevalence of urogenital schistosomiasis was determined for each group and the performance of the real-time PCR was compared with the conventional techniques. Results A total of 428 participants were enrolled in this study including 87 (20.4%) pre-school children (1–5 years), 262 (61.3%) school-aged children between (5–14 years), 17 (3.9%) adolescents (15–17 years) and 62 (14.4%) female adults. The comparison of the diagnostic techniques has shown that the prevalence of urogenital schistosomiasis is higher using molecular technique (34.6%) compared to microscopy (20.3%). The percentage rate of haematuria using Hemastix was 23.1%. School-aged children between 5 and 14 years old were the most affected with 29.0% and 43.1% under microscopy and RT-PCR, respectively. In female participants, microscopic prevalence decreases with age, from 21.4% in school-aged children to 17.6% in adolescents and 9.7% in adults. There was good correlation between the number of eggs per 10 ml and the cycle threshold range. Conclusion These results show the importance of using molecular tools in the surveillance of schistosomiasis particularly in pre-school children and women of reproductive age. Graphical Abstract
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