Relevant bibliographies by topics / Obtusifoliol

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Academic literature on the topic 'Obtusifoliol'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

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Journal articles on the topic "Obtusifoliol"

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Warrilow, Andrew G. S., Josie E. Parker, Claire L. Price, W. David Nes, Edward P. Garvey, William J. Hoekstra, Robert J. Schotzinger, Diane E. Kelly, and Steven L. Kelly. "The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme." Antimicrobial Agents and Chemotherapy 60, no. 8 (May 9, 2016): 4530–38. http://dx.doi.org/10.1128/aac.00349-16.

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ABSTRACTCryptococcosis is a life-threatening disease often associated with HIV infection. ThreeCryptococcusspecies CYP51 enzymes were purified and catalyzed the 14α-demethylation of lanosterol, eburicol, and obtusifoliol. The investigational agent VT-1129 bound tightly to all three CYP51 proteins (dissociation constant [Kd] range, 14 to 25 nM) with affinities similar to those of fluconazole, voriconazole, itraconazole, clotrimazole, and ketoconazole (Kdrange, 4 to 52 nM), whereas VT-1129 bound weakly to human CYP51 (Kd, 4.53 μM). VT-1129 was as effective as conventional triazole antifungal drugs at inhibiting cryptococcal CYP51 activity (50% inhibitory concentration [IC50] range, 0.14 to 0.20 μM), while it only weakly inhibited human CYP51 activity (IC50, ∼600 μM). Furthermore, VT-1129 weakly inhibited human CYP2C9, CYP2C19, and CYP3A4, suggesting a low drug-drug interaction potential. Finally, the cellular mode of action for VT-1129 was confirmed to be CYP51 inhibition, resulting in the depletion of ergosterol and ergosta-7-enol and the accumulation of eburicol, obtusifolione, and lanosterol/obtusifoliol in the cell membranes.
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Taton, M., and A. Rahier. "Properties and structural requirements for substrate specificity of cytochrome P-450-dependent obtusifoliol 14 α-demethylase from maize (Zea mays) seedlings." Biochemical Journal 277, no. 2 (July 15, 1991): 483–92. http://dx.doi.org/10.1042/bj2770483.

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The biochemical properties of cytochrome P-450-dependent obtusifoliol 14 alpha-demthylase (P-450OBT.14DM) from maize (Zea mays) seedlings were defined. In particular, the enzyme was shown by differential centrifugation to be localized in the endoplasmic reticulum. P-450OBT.14DM had an apparent Km of 160 +/- 5 microM and an apparent Vmax of 65 +/- 5 pmol/min per mg of protein for its best substrate, obtusifoliol. The substrate specificity of P-450OBT.14DM was thoroughly investigated by comparing the demethylation of obtusifoliol with that of a series of 15 natural or novel synthetic analogues of obtusifoliol. The results obtained clearly indicate that three distinct domains of the sterol substrate are governing obtusifoliol demethylation by P-450OBT.14DM. They revealed that (i) P-450OBT.14DM has probably a specific apolar binding site for the side chain, (ii) the delta 8-double bond is an absolute requirement for substrate demethylation and (iii) the 3-hydroxy group plays a critical role in the enzyme-substrate interaction. Interestingly the binding site, beyond the C-3 position, contains a cleft which cannot accommodate a 4 beta-methyl substituent present in lanosterol or eburicol, the precursors of 14-desmethylsterols respectively in mammals and yeast. This result indicates that P-450OBT.14DM is a novel constitutive cytochrome P-450 with a high degree of substrate and product specificity.
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Lepesheva, Galina I., W. David Nes, Wenxu Zhou, George C. Hill, and Michael R. Waterman. "CYP51 fromTrypanosoma bruceiIs Obtusifoliol-Specific†." Biochemistry 43, no. 33 (August 2004): 10789–99. http://dx.doi.org/10.1021/bi048967t.

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Rahier, Alain, and Maryse Taton. "Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14α-demethylase." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1125, no. 2 (April 1992): 215–22. http://dx.doi.org/10.1016/0005-2760(92)90048-z.

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Tanaka, Reiko, Kazuaki Kasubuchi, Shunji Kita, and Shunyo Matsunaga. "Obtusifoliol and related steroids from the whole herb of Euphorbia chamaesyce." Phytochemistry 51, no. 3 (June 1999): 457–63. http://dx.doi.org/10.1016/s0031-9422(99)00041-2.

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Falsone, Gioacchino, and Claudia Schneider. "Über Inhaltsstoffe von Euphorbiaceae, 8. Mitt. [1]. Triterpenester und Triterpenalkohole aus Euphorbia biglandulosa Desf. / Constituents of Euphorbiaceae, 8. Comm. [1]. Triterpen Esters and Triterpen Alcohols from Euphorbia biglandulosa Desf." Zeitschrift für Naturforschung B 40, no. 4 (April 1, 1985): 553–55. http://dx.doi.org/10.1515/znb-1985-0420.

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Fatty acids and acetic acid esters of lanosterol and cycloartenol and triterpens alcohols were isolated from the latex of Euphorbia biglandulosa Desf. The triterpenesters were identified as (E,Z)-2,4-decadienoyllanosterol (1a), (E,Z)-2,4-octadienoyllanosterol (1b), (E,Z)-2,4-oc- tadienoylcycloartenol (2a), (2E,4Z)-2,4,6-decatrienoyllanosterol (1c), (2E,4Z)-2,4,6-deca- trienoylcycloartenol (2b), lanosterylacetat (1d) and cycloartenylacetat (2c) by IR-, 1H-NMR- and MS-spectroscopy and hydrolysis. The triterpens alcohols were identified as butyrospermol, cyclo­artenol, 24-methylencycloartanol and obtusifoliol.
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Marichal, Patrick, Jos Gorrens, Leen Laurijssens, Karen Vermuyten, Carl Van Hove, Ludo Le Jeune, Peter Verhasselt, et al. "Accumulation of 3-Ketosteroids Induced by Itraconazole in Azole-Resistant Clinical Candida albicans Isolates." Antimicrobial Agents and Chemotherapy 43, no. 11 (November 1, 1999): 2663–70. http://dx.doi.org/10.1128/aac.43.11.2663.

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ABSTRACT The effects of itraconazole on ergosterol biosynthesis were investigated in a series of 16 matched clinical Candida albicans isolates which had been previously analyzed for mechanisms of resistance to azoles (D. Sanglard, K. Kuchler, F. Ischer, J. L. Pagani, M. Monod, and J. Bille, Antimicrob. Agents Chemother., 39:2378–2386, 1995). Under control conditions, all isolates contained ergosterol as the predominant sterol, except two strains (C48 and C56). In isolates C48 and C56, both less susceptible to azoles than their parent, C43, substantial concentrations (20 to 30%) of 14α-methyl-ergosta-8,24(28)-diene-3β,6α-diol (3,6-diol) were found. Itraconazole treatment of C43 resulted in a dose-dependent inhibition of ergosterol biosynthesis (50% inhibitory concentration, 2 nM) and accumulation of 3,6-diol (up to 60% of the total sterols) together with eburicol, lanosterol, obtusifoliol, 14α-methyl-ergosta-5,7,22,24(28)-tetraene-3βol, and 14α-methyl-fecosterol. In strains C48 and C56, no further increase of 3,6-diol was observed after exposure to itraconazole. Ergosterol synthesis was less sensitive to itraconazole inhibition, as was expected for these azole-resistant isolates which overexpress ATP-binding cassette transporter genes CDR1 andCDR2. In addition to 3,6-diol, substantial amounts of obtusifolione were found after exposure to itraconazole. This toxic 3-ketosteroid was demonstrated previously to accumulate after itraconazole treatment in Cryptococcus neoformans andHistoplasma capsulatum but has not been reported inCandida isolates. Accumulation of obtusifolione correlated with nearly complete growth inhibition in these azole-resistant strains compared to that found in the susceptible parent strain, although the onset of growth inhibition only occurred at higher concentrations of itraconazole. ERG25 and ERG26 are the only genes assigned to the 4-demethylation process, of which the 3-ketoreductase is part. To verify whether mutations in theseERG25 genes contributed to obtusifolione accumulation, their nucleotide sequences were determined in all three related isolates. No mutations in ERG25 alleles of isolates C48 and C56 were found, suggesting that this gene is not involved in obtusifolione accumulation. The molecular basis for the accumulation of this sterol in these two strains remains to be established.
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Kushiro, Masayo, Takeshi Nakano, Ken Sato, Kazutoshi Yamagishi, Tadao Asami, Akihiko Nakano, Suguru Takatsuto, Shozo Fujioka, Yutaka Ebizuka, and Shigeo Yoshida. "Obtusifoliol 14α-Demethylase (CYP51) Antisense Arabidopsis Shows Slow Growth and Long Life." Biochemical and Biophysical Research Communications 285, no. 1 (July 2001): 98–104. http://dx.doi.org/10.1006/bbrc.2001.5122.

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Bailen, Maria, Mourad Daoubi Khamlichi, Ahmed Benharref, Rafael A. Martinez-Diaz, and Azucena Gonzalez-Coloma. "New Bioactive Semisynthetic Derivatives of 31-Norlanostenol and Obtusifoliol from Euphorbia Officinarum." Natural Product Communications 11, no. 6 (June 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100609.

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Fifteen semisynthetic terpenoid derivatives from the major latex components of Euphorbia officinarum have been evaluated against the insect pest Spodoptera littoralis, two species of protozoan parasites, Trypanosoma cruzi and Leishmania infantum, and also against insect Sf9 and mammalian CHO cells to test their selective cytotoxicity. Our results showed that 40% of the test substances were postingestive toxicants to S. littoralis. All the tested derivatives had cytotoxic effects on insect-derived Sf9 cells, whereas mammalian CHO cells were affected by a lower number of compounds (47%). Furthermore, 87% of the test compounds had antiparasitic effects on bothi. infantum and T. cruzi, with some of them being selective parasite toxicants.
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Bargar, Tom M., Jacob Secor, Lowell D. Markley, Brian A. Shaw, and Jon A. Erickson. "A comparative molecular field analysis study of obtusifoliol 14α-methyl demethylase inhibitors." Pesticide Science 55, no. 11 (October 15, 1999): 1059–69. http://dx.doi.org/10.1002/(sici)1096-9063(199911)55:11<1059::aid-ps57>3.0.co;2-j.

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Dissertations / Theses on the topic "Obtusifoliol"

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Schulz, Thomas. "Rumex obtusifolius L. im Wirtschaftsgrünland." Doctoral thesis, Humboldt-Universität zu Berlin, Landwirtschaftlich-Gärtnerische Fakultät, 2013. http://dx.doi.org/10.18452/16731.

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Der Stumpfblättrige Ampfer (Rumex obtusifolius) ist eine häufig auftretende Schadpflanze des Grünlandes. Er verdrängt wertvolle Futtergräser und beeinträchtigt die Grundfutterqualität und Futterkonservierung negativ. Zahlreiche Publikationen beschäftigten sich mit der Botanik und der allgemeinen Schadwirkung, zu den wirtschaftlichen Auswirkungen wurden bisher kaum belastbare Aussagen veröffentlicht. In 2-jährigen Felderhebungen wurden an 3 Standorten in Sachsen und Thüringen zu jeweils 4 Aufwüchsen die Parameter Abundanz, Deckungsgrad, Ertragsanteil, Trockenmasseertrag sowie Futterwert und Inhaltsstoffe von Ampfer in Relation zu Gras bei unterschiedlich starkem Ampferbefall untersucht. Die Erfassung der projektiven Deckung war deutlich besser zur Quantifizierung des Schadauftretens geeignet als die Abundanz. Der Ertragsanteil betrug das 0,69-fache des Ampfer-Deckungsgrades. Der Gesamt-TM-Ertrag wurde bei steigendem Ampferbefall regelmäßig nicht negativ beeinflusst. Die Energiedichte von Ampfer lag rund 25 % unter der der jeweiligen Graskomponente. Aus dem geringeren Trockenmasseertrag und der niedrigeren Energiedichte ergibt sich bei Ampferbekämpfung und Nachsaat ein Potenzial zur Steigerung des Energieertrages der Fläche. In Silierversuchen wurde die Wirkung von verschiedenen Mischungsanteilen von R. obtusifolius auf den Konservierungserfolg von Lolium perenne untersucht. Steigende Ampferanteile wirkten sich negativ auf das Gärsäuremuster der Grassilagen aus und führten zu einem zusätzlichen Rückgang der Energiedichte der anteiligen Ampferkomponente von rund 10 %. Es wurde ein mathematisches Modell entwickelt, mit dem sich auf Basis der Parameter Gesamt-TM-Ertrag des Bestandes, Energiedichte des Grases, dem Ampfer-Deckungsgrad und unter Einbeziehung des Milchpreises der potenziell entgangene Deckungsbeitrag berechnen lässt. Daraus kann für unterschiedliche Kosten-, Ertrags- und Erlössituationen eine flexible wirtschaftliche Schadensschwelle abgeleitet werden.
Docks are one of most frequently arising problem weeds of the permanent grassland. It suppresses valuable fodder grasses and negatively influences the basic fodder quality. Numerous publications concern themselves with botany and the general side-effect; chargeable statements to economic effects were so far however not published. In two-year field collections at three locations in eastern part of Germany the relations between abundances, coverage, yield part, dry matter yield of grass and docks as well as the worth-giving ingredients of both were analyzed. Different recording methods were comparatively evaluated. Estimating or measuring the weed ground cover was more suitable for quantifying the loss in economic value due to presence of Docks then plant counting’s. The proportional yield part of docks can be derived however surely from the percent of ground cover multiplied by 0.69. The total dry matter yield was regularly not affected by raising colonization of Docks. The net energy of docks was 25 % under that from grass. The low dry matter yield and the reduced net energy content of Docks in comparison to grass appearing a potential for raising net energy yield per hectare after controlling the docks and reestablishing the sward. In ensiling studies the effect of rising mixture portions of docks on preservation success of Italian rye grass was examined. It was stated that docks affects the fermenting acid sample negatively and leads to a proportionate decrease of net energy content of the silage feed of approximately 10 %. A mathematical model has been developed, based on entire dry matter yield of the site, net energy content of the grass, ground canopy of docks and milk proceeds. It allows the forecast of non realized income, which could be used in case of removal of docks and recovering gaps with grass comparably to the existing grass. From this point a flexible economical damage threshold can be derived for different costing, yield and proceeds situations.
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Souto, Augusto Lopes. "Análise Metabolômica de Peperomia obtusifolia (L.) A. Dietr." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8052.

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The species Peperomia obtusifolia (L.) A. Dietr, which belongs to the Piperaceae family, is a well-known plant, distributed from Mexico to South America. Previous phytochemical studies demonstrated the presence of compounds from several classes, such as: lignans, flavonoids, amides, phenolic compounds and chromenes, which demonstrated interesting biological activities. This work describes the metabolomic analysis of Peperomia obtusifolia, which study in real time, the metabolism of this species in many kinds of scenarios. However, to accomplish this study, firstly it was developed a standard protocol, capable of preparing the samples in a reproducible way, enabling the following metabolomic studies to generate reliable results. Later, it was conducted the metabolomic study of Peperomia obtusifolia and its varieties, by fingerprinting analysis, in order to characterize the metabolomic profiles of each one of them. Furthermore, it was also evaluated the behavior of the species against the stress induced by the herbivory of Monoplatus sp. In general, the analyzes were conducted by NMR of 1H (which the data was interpreted by PCA), mass spectrometry, HPLC, GC and its hyphenated techniques. As a result, it was found that, despite the fact that the Peperomia obtusifolia varieties belong to the same species, they had different metabolomes. Regarding the study of the biotic stress against the plant, changes were detected on the metabolomic profile of the attacked plants, indicating a response against the herbivore attack. As a major result of this research, it can be highlighted the fact that the same changes were also detected on the metabolome of the intact plants closed to the attacked ones, indicating a sort of interplant communication by volatile compounds, capable to induce the neighborhood yet not attacked, to be prepared for an imminent attack, giving them a better chance of survival.
A espécie Peperomia obtusifolia (L.) A. Dietr, pertencente à família Piperaceae, é uma planta amplamente conhecida, cuja ocorrência vai desde o México até a América do Sul. Estudos fitoquímicos anteriores revelaram a presença de compostos de diversas classes, como: lignanas, flavonoides, amidas, compostos fenólicos e cromenos, os quais demonstraram atividade biológica bastante promissora. Este trabalho aborda a análise metabolômica de Peperomia obtusifolia, que visa estudar em tempo real o metabolismo desta espécie em diversos tipos de cenários. Entretanto, para que este estudo fosse realizado, primeiramente foi desenvolvido um protocolo padrão, capaz de preparar amostras de maneira reprodutível, possibilitando assim uma análise metabolômica que gerasse resultados fidedignos. Posteriormente foi realizado o estudo metabolômico de Peperomia obtusifolia e suas variedades, por análise de fingerprinting, que visa caracterizar os perfis metabólicos de cada organismo. Além disso, também foi avaliado o metaboloma da espécie frente ao estresse biótico provocado pela herbivoria do besouro Monoplatus sp. As análises das amostras foram realizadas por meio de RMN de 1H (cujos dados foram interpretados por PCA), espectrometria de massas, CLAE, CG e técnicas hifenadas. Como resultado, descobriu-se que apesar das variedades de Peperomia obtusifolia pertencerem à mesma espécie, elas possuíam metabolomas diferentes. Já em relação ao estudo de estresse biótico aplicado à planta, foram detectadas nas plantas predadas, alterações nos perfis metabolômicos, configurando-se uma resposta contra o ataque provocado. Considera-se um resultado de maior importância, o fato de que plantas intactas que estavam próximas às predadas, responderam ao ataque de maneira semelhante, indicando assim, uma comunicação inter-plantas por meio de compostos voláteis, capaz de induzir a vizinhança ainda não atacada a se preparar para reagir ao ataque, possibilitando assim, maior chance de sobrevivência.
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Niggli, Urs. "Bekaempfung von 'Rumex obtusifolius' L. und Bestandeslenkung in intensiv bewirtschafteten Naturwiesen /." Zürich : [s.n.], 1985. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7757.

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Keary, Ian Paul. "The weed Rumex obtusifolius, a foliar rust and a herbivorous beetle." Thesis, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397411.

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Kreimer, Detlef. "Biologie, Ökologie und Kontrolle von Senna obtusifolia (L.) Irwin & Barneby im Zamfara-Weidegebiet in der Sudansavanne Nordwest-Nigerias." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/988753936/34.

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McFarlane, Anne Margaret. "The effect of ozone on Gastrophysa viridula (Degeer) feeding on Rumex obtusifolius." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307400.

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Araújo, Neto Vitor. "Estudo das atividades antinociceptiva, anti-inflamatória e antioxidante da Sideroxylon obtusifolium (Sapotaceae)." Universidade Federal de Sergipe, 2009. https://ri.ufs.br/handle/riufs/3290.

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Sideroxylon obtusifolium belongs to the family Sapotaceae. This study aimed to contribute to the scientific knowledge of the antinociceptive, anti-inflammatory and antioxidant properties of the steam bark of Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn, popularly known as quixabeira and used to treat pain and inflammation. The ethanol crude extract of the dried and triturated stem bark (EE, 459,60 g) was submitted to liquidliquid extraction (400 g) with hexane, chloroform and ethyl acetate to give fractions hexane (11,90 g), chloroform (6,08 g), ethyl acetate (43,72 g) and hydromethanol (181,35 g). The EE and its fractions were submitted to phytochemical analysis, which detected groups of secondary metabolites such as phenols, flavanoids, xanthones, steroids, triterpens, saponins, tannins and cathechins. The effects of the extract and its fractions in nociception (using the models of abdominal writhing induced by acetic acid, hot plate and formalin in mice), inflammation (using the models of paw edema and peritonitis induced by carrageenan in mice) and antioxidant (using the scavenging of DPPH method) were evaluated. In the model of abdominal writhing induced by acetic acid, the oral treatment with of EE at 400 mg/kg had similar inhibition to that of AAS. The model of hot plate showed that the EE did not cause an increase in the latency time by the thermal stimulus at 55 ± 0.5°C, suggesting does not have central antinociceptive action. The EE only inhibited the second phase in the formalin test, which suggested that had inflammatory antinociception, which showed possibly acts by inhibiting the enzyme ciclo-oxygenase (COX). When evaluating the anti-inflammatory action by the carrageenan-induced paw edema model, the oral feeding of the EE was effective in reducing the edema-forming response between second and fourth hour after injecting carrageenan. Peritonitis model showed that the oral administration of EE was effective in reducing the leukocyte migration after 4 h of the i.p. injection of carrageenan, which was similar to dexamethasone. The DPPH assay showed the EE and its fractions ethyl acetate and hydromethanol present a antioxidant activity in vitro, which can be related to the presence of polyphenols. Therefore, the extract of S. obtusifolium has relevant phytochemical, which can be influencing the anti-inflammatory, analgesic, and antioxidant activities, suggesting it can be submitted to new pharmacological studies and clinical trial.
A planta escolhida pertence à família Sapotaceae. Este estudo teve como objetivo contribuir para o conhecimento científico das ações antinociceptiva, anti-inflamatória e antioxidante da entrecasca da Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn, popularmente conhecida como quixabeira e usada no tratamento da dor e inflamação. Para tanto, o extrato etanólico bruto (EE, 459,60 g) da entrecasca da planta seca e triturada foi submetido à extração líquido-líquido (400 g) com hexano, clorofórmio e acetato de etila, obtendo assim as frações hexânica (11,90 g), clorofórmica (6,08 g), acetato de etila (43,72 g) e hidrometanólica (181,35 g). Este extrato e suas frações foram submetidos à prospecção fitoquímica detectando assim grupos de metabólitos secundários relevantes, como fenóis, flavonóides, xantonas, esteróides, triterpenóides, saponinas, taninos e catequinas. Em seguida, foram avaliados os efeitos desse extrato na nocicepção (nos modelos de contorções abdominais induzida por ácido acético, placa quente e formalina em camundongos), inflamação (nos modelos de edema de pata e de peritonite induzidos por carragenina em ratos) e oxidação (método do seqüestro do DPPH). No modelo de contorções abdominais induzida por ácido acético, o EE quando administrado por via oral na concentração de 400 mg/kg apresentou inibição similar ao AAS. Já no modelo da placa quente o EE não influenciou no aumento do tempo de latência pelo estímulo térmico de 55 ± 0,5°C, sugerindo não tem ação antinociceptiva central. Observando o modelo da formalina o efeito do EE apresentou inibição apenas na segunda fase mostrando antinocicepção do tipo inflamatória, sugerindo ação através da inibição da ciclo-oxigenase (COX). Na avaliação da ação anti-inflamatória pelo modelo de edema de pata induzido por carragenina em ratos, demonstrou que a administração oral do EE foi efetivo em reduzir a resposta edematogênica entre a segunda e quarta hora após a injeção de carragenina. No modelo de peritonite demonstrou que o EE por via oral foi efetivo em reduzir a migração leucocitária após 4 h a injeção i.p. de carragenina de forma similar à dexametasona. O método do seqüestro do DPPH permitiu estabelecer a ação antioxidante in vitro do EE e das frações acetato de etila e hidrometanólica, que pode estar relacionada aos compostos polifenólicos presentes. Assim, identificamos que o extrato da S. obtusifolium possui compostos fitoquímicos que influenciaram nas atividades anti-inflamatória, analgésica e antioxidante.
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Froehlich, Diego Lacir. "Intoxicação espontânea e experimental por folhas e vagens da planta Senna obtusifolia (Leguminosae) em bovinos." Universidade do Estado de Santa Catarina, 2010. http://tede.udesc.br/handle/handle/957.

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A disease of cattle with clinical and pathological presentation of acute myopathy was studied in the cities of Bom Jesus and Xanxerê in the State of Santa Catarina. Clinically, the disease was characterized by difficulty in walking, recumbency and death within 2 to 13 days after the onset of clinical symptoms. At necropsy were observed pale areas in the skeletal muscles mainly in the muscles of the hindquarters and the scapular area. The main microscopic lesions were hyaline degeneration and necrosis with fragmentation of the fibers, accompanied by mononuclear cell infiltrates. In the property there was great amount of S. obtusifolia that demonstrated that was consumed by the animals. The disease was reproduced experimentally in cattle fed with green leaves and pods of Senna obtusifolia in daily doses of 8g/kg (4 days), 10 g / kg (5 days), 15 g / kg (3 days) and a single dose 30g / kg body weight. This study aimed to evaluate the epidemiological and clinical lesions of a disease that affects the skeletal muscles of cattle and experimentally reproduce the disease through the administration of leaves and pods of Senna obtusifolia
Uma doença de bovinos com quadro clínico patológico de miopatia aguda foi estudada nos municípios de Xanxerê e Bom Jesus, SC. Clinicamente a enfermidade caracterizou-se por dificuldade em caminhar, decúbito esternal e morte entre dois a 13 dias após o inicio dos sinais clínicos. Um dos bovinos se recuperou e voltou a andar. Na necropsia foram observadas áreas pálidas na musculatura esquelética principalmente nos músculos dos membros posteriores e da região escapular. Ao exame microscópio, a principal lesão foi degeneração hialina e necrose com fragmentação das fibras, acompanhadas de infiltrado mononuclear. Na propriedade havia grande quantidade de S. obtusifolia com sinais de ter sido ingerida A doença foi reproduzida experimentalmente em bovinos com a administração de folhas e vagens verdes de Senna obtusifolia em doses diárias de 8g/kg (4 dias), 10g/kg (5 dias), 15g/kg (3 dias) e em dose única 30g/kg de peso vivo. O objetivo do presente trabalho foi avaliar os aspectos epidemiológicos clínicos e lesionais da enfermidade que afeta a musculatura esquelética dos bovinos e reproduzir experimentalmente a doença através da administração de folhas e vagens de Senna obtusifolia
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Firmino, de Santana Mauricélia. "Uso de planejamento fatorial na extração de lectinas de entrecasca de Sideroxylon obtusifolium (quixabeira) : purificação e caracterização parcial." Universidade Federal de Pernambuco, 2010. https://repositorio.ufpe.br/handle/123456789/1693.

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Este trabalho trata da extração de uma lectina da entrecasca de Sideroxylon obtusifolium utilizando planejamento fatorial completo seguido da purificação da lectina através de fracionamento salino e cromatografia de afinidade em quitina, além da caracterização parcial e avaliação da atividade antimicrobiana. Os resultados revelaram que as melhores condições de extração, obtidas através do planejamento fatorial 24 + 4 pontos centrais, foi a na temperatura de 4ºC, com tempo de extração de 4h, em pH 6,0 e com a concentração de NaCl 0,15 M. A partir destes dados, extrações em tampão citrato fosfato e fosfato de sódio, na faixa de pH (6,0 a 7,5) foram efetuados sendo selecionada a extração em tampão citrato fosfato, pH 6,5; o qual apresentou melhor atividade hemaglutinante específica (AHE) com eritrócitos de coelho. O fracionamento salino revelou que a fração 60-80% (F60-80) foi a que apresentou a maior AHE, a qual foi parcialmente inibida por glicose e totalmente inibida por N-acetil-D-glicosamina. A lectina denominada SoBL (Sideroxylon Obtusifolium Bark Lectin) foi obtida da cromatografia em quitina após eluição com ácido acético 1 M. SoBL é uma proteína termoestável, mantendo sua AH até 100ºC, após 30 min de aquecimento. A avaliação da estabilidade frente a diferentes valores de pH indicou que a lectina apresentou maior AH no pH de 5,0. SDS-PAGE mostrou que SoBL é uma lectina de baixa massa molecular (6,0 kDa) e não glicosilada. SoBL (40μg) não inibiu o crescimento das bactérias Bacillus subtilis, Streptococcus faecalis, Staphylococcus aureus, pseudomonas aeroginosa e Klebsiela pneumoniae e dos fungos do gênero Fusarium. Em conclusão, uma lectina termoestável e de baixa massa molecular foi obtida da entrecasca de S. obtusifolium por cromatografia de afinidade em quitina, a qual aparentemente, não apresentou atividade antimicrobiana
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Kwon, Ohseok. "Effects of nitrogen and different habitat types on insects associated with Rumex obtusifolius L." Thesis, Lancaster University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337342.

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Books on the topic "Obtusifoliol"

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Burrill, L. C. Curly dock and broadleaf dock, Rumex crispus L. and R. obtusifolius L. [Corvallis, Or.]: Oregon State University Extension Service, 1992.

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Gouldsmith, Speck Frank. Spirit medicine: Native American uses of common everlasting (Pseudognaphalium obtusifolium) in eastern North America. Norman, Okla: Sam Noble Oklahoma Museum of Natural History, 2002.

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Book chapters on the topic "Obtusifoliol"

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Taton, Maryse, Florence Salmon, and Alain Rahier. "Plant Sterol Biosynthesis. Cytochrome P-450 Obtusifoliol 14α-Methyl Demethylase a Key Enzymatic Step." In Plant Lipid Metabolism, 341–43. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-015-8394-7_93.

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Haplophyllum obtusifolium (Ledeb.) Ledeb. (H. obtusifolium var. eriocarpum Freyn.; Ruta obtusifolium Ledeb.)." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 841–42. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2729.

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Khare, C. P. "Cassia obtusifolia Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_305.

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Tang, Weici, and Gerhard Eisenbrand. "Erycibe obtusifolia Benth." In Chinese Drugs of Plant Origin, 499–500. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-73739-8_64.

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Paniagua-Zambrana, Narel Y., Rainer W. Bussmann, and Carolina Romero. "Hesperomeles obtusifolia (Pers.) Lindl. Clethraceae." In Ethnobotany of Mountain Regions, 937–39. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-28933-1_139.

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Paniagua-Zambrana, Narel Y., Rainer W. Bussmann, and Carolina Romero. "Hesperomeles obtusifolia (Pers.) Lindl. Clethraceae." In Ethnobotany of Mountain Regions, 1–3. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-77093-2_139-1.

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Haplophyllum ramosissimum (Pauls.) Vved. (H. obtusifolium var. ramosissimum Pauls.)." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 842–43. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2733.

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Wang, Yulan. "Cassia Obtusifolia L. 决明子 (Juemingzi, Semen Cassiae)." In Dietary Chinese Herbs, 315–19. Vienna: Springer Vienna, 2015. http://dx.doi.org/10.1007/978-3-211-99448-1_35.

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VaÁZquez-Yanes, C., and A. Orozco-Segovia. "Dispersal of seeds by animals: effect on light controlled dormancy in Cecropia obtusifolia." In Tasks for vegetation science, 71–77. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4812-9_7.

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Martínez-Ramos, Miguel, and Elena Alvarez-Buylla. "Seed dispersal, gap dynamics and tree recruitment: the case of Cecropia obtusifolia at Los Tuxtlas, Mexico." In Tasks for vegetation science, 333–46. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4812-9_29.

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Conference papers on the topic "Obtusifoliol"

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Rangel, Leonardo, Jose Santos, and Robson Farias. "Atividade moluscicida de extrato butanólico e nanoformulação de Sideroxylon obtusifolium." In V Seminário Anual Científico e Tecnológico. Instituto de Tecnologia em Imunobiológicos, 2017. http://dx.doi.org/10.35259/isi.sact.2017_26151.

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Wang, Huiqin, and Haixing Liu. "Determination of amygdalin in Cassia obtusifolia L. by capillary electrophoresis." In INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FBSE 2018). Author(s), 2019. http://dx.doi.org/10.1063/1.5085552.

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Damian, Schori, Anken Thomas, and Seatovic Dejan. "Using Fully Convolutional Networks for Rumex Obtusifolius Segmentation, a Preliminary Report." In 2019 International Symposium ELMAR. IEEE, 2019. http://dx.doi.org/10.1109/elmar.2019.8918914.

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Flaih, Laheeb Subhy, and Narjis Hadi Al-Saadi. "Green synthesis of silver nanoparticles from Cassia obtusifolia leaves extract: Characterization and antioxidant activity." In INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0027542.

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Rivera Mondragón, A., S. Bijttebier, K. Foubert, C. Caballero-George, and L. Pieters. "Isolation and identification of flavonoids, saponins and two new flavolignans from Cecropia obtusifolia leaves collected in Panama." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608187.

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HALAWANE, JAFRED E. "Variasi genetik pertumbuhan tanaman uji keturunan nyatoh (Palaquium obtusifolium) umur 1,5 tahun di Hutan Penelitian Batuangus, Sulawesi Utara." In Seminar Nasional Masyarakat Biodiversitas Indonesia. Masyarakat Biodiversitas Indonesia, 2015. http://dx.doi.org/10.13057/psnmbi/m010426.

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Dantas, J. A., L. A. S. Correia, F. C. Felix, F. S. Araújo, and M. V. Pacheco. "Alelopatia do extrato foliar de Sideroxylon obtusifolium Roem. & Schult. sobre a germinação de sementes de Mimosa caesalpiniifolia Benth." In VIII Simpósio Brasileiro de Pós-Graduação em Ciências Florestais. Recife, Pernambuco, Brasil: Universidade Federal Rural de Pernambuco, 2014. http://dx.doi.org/10.12702/viii.simposfloresta.2014.129-625-1.

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