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1

Macovei, Luana Andreea, V. Cristescu, Mihaela Debita, and C. A. Dinu. "Oral Manifestations of Osteoarticular Diseases." Revista de Chimie 68, no. 10 (November 15, 2017): 2440–42. http://dx.doi.org/10.37358/rc.17.10.5901.

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Human body acts as a whole and this leads to an increased occurrence of oral manifestations during the onset and development of systemic diseases. Therefore, oral pathological manifestations play an important role in the diagnosis, prognosis and treatment of diseases with osteoarticular involvement. General pathology has a strong impact on oral health which in turn is influenced by systemic factors. Oral manifestations can be used for making an early diagnosis of a serious condition that can be cured with appropriate therapy. Oral lesions can be explained by pathological processes and correlated with systemic diseases. When oral symptoms and signs are present, the disease is already in an advanced stage, due to the fact that the oral cavity is usually affected by a generalized disease. The mouth is part of the digestive system, but it has various symptoms caused by diseases located in other regions. 98 patients with oral manifestations of diseases with osteoarticular involvement were followed up in a private dental clinic from Iasi over a period of 3 years between June 2013 and July 2016. 47 patients were male (47.95%) and 51 were female (52.05%), aged between 18 and 65 years old, with a peak incidence between the ages of 45 and 60. The complex structure of the oral cavity was thoroughly explored (lips, lip mucosa, the corners of the mouth, gingival labial sulcus, oral vestibule, the internal face of the cheeks, the outer surface of gums, the floor and the ceiling of the oral cavity or the hard and the soft palate). The health status of the body is reflected by the health of the oral mucosa, which can be seen as a marker of various systemic diseases.
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2

Ash, M. M., and C. M. Phillips. "Parasitic Diseases With Cutaneous Manifestations." North Carolina Medical Journal 77, no. 5 (September 1, 2016): 350–54. http://dx.doi.org/10.18043/ncm.77.5.350.

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3

Robson, Kristi J., and Warren W. Piette. "CUTANEOUS MANIFESTATIONS OF SYSTEMIC DISEASES." Medical Clinics of North America 82, no. 6 (November 1998): 1359–79. http://dx.doi.org/10.1016/s0025-7125(05)70419-3.

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4

Rao, Devika. "Pulmonary Manifestations of Pediatric Diseases." JAMA 304, no. 10 (September 8, 2010): 1127. http://dx.doi.org/10.1001/jama.2010.1306.

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5

Koulaouzidis;, A., S. Bhat;, and J. Moschos. "Skin manifestations of liver diseases." Annals of Hepatology 6, no. 3 (July 2007): 181–84. http://dx.doi.org/10.1016/s1665-2681(19)31926-x.

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6

Baldassano, Vincent F. "Ocular manifestations of rheumatic diseases." Current Opinion in Ophthalmology 9, no. 6 (December 1998): 85–88. http://dx.doi.org/10.1097/00055735-199812000-00015.

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7

Hostein, J., and J. Fournet. "Gastrointestinal Manifestations of Collagen Diseases." Digestive Diseases 4, no. 4 (1986): 240–52. http://dx.doi.org/10.1159/000171154.

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8

Gran, Jan Tore, and Gunnar Husby. "Joint Manifestations in Gastrointestinal Diseases." Digestive Diseases 10, no. 5 (1992): 274–94. http://dx.doi.org/10.1159/000171365.

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9

Gran, Jan Tore, and Gunnar Husby. "Joint Manifestations in Gastrointestinal Diseases." Digestive Diseases 10, no. 5 (1992): 295–312. http://dx.doi.org/10.1159/000171366.

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10

Brieva, Joaquin C. "Mucocutaneous Manifestations of Viral Diseases." Archives of Dermatology 139, no. 5 (May 1, 2003): 678. http://dx.doi.org/10.1001/archderm.139.5.678-b.

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11

Hubert, K. C., and J. S. Palmer. "Urologic manifestations of genetic diseases." Drugs of Today 41, no. 9 (2005): 623. http://dx.doi.org/10.1358/dot.2005.41.9.904729.

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12

Menon, S., and D. A. Isenberg. "Rheumatological manifestations of haematological diseases." Annals of the Rheumatic Diseases 54, no. 10 (October 1, 1995): 787–95. http://dx.doi.org/10.1136/ard.54.10.787.

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13

BAER, A. N. "Cutaneous Manifestations of Rheumatic Diseases." Annals of the Rheumatic Diseases 56, no. 4 (April 1, 1997): 228. http://dx.doi.org/10.1136/ard.56.4.228.

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14

JONES, N. S. "Nasal manifestations of rheumatic diseases." Annals of the Rheumatic Diseases 58, no. 10 (October 1, 1999): 589–90. http://dx.doi.org/10.1136/ard.58.10.589.

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15

Kudishina, M. M., I. V. Kozlova, and E. A. Yavaeva. "Skin manifestations of inflammatory bowel diseases." Experimental and Clinical Gastroenterology, no. 3 (June 22, 2020): 113–17. http://dx.doi.org/10.31146/1682-8658-ecg-175-3-113-117.

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The urgency of inflammatory bowel diseases increases every year as the prevalence of pathology in the world increases. Unlike most diseases, inflammatory bowel diseases do not always debut classic intestinal symptoms, often in the debut of pathology — extraintestinal manifestations.The article describes three clinical cases of patients with IBD and skin manifestations, different outcomes and management tactics.
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16

Parfenov, A. I., A. V. Kagramanova, and O. V. Knyazev. "Systemic manifestations of inflammatory bowel diseases." Terapevticheskii arkhiv 92, no. 2 (April 27, 2020): 4–11. http://dx.doi.org/10.26442/00403660.2020.02.000535.

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The article is devoted to the current data regarding the pathogenesis, classification and frequency of extraintestinal manifestations (EIMs) in inflammatory bowel diseases. We discuss two distinct theories of EIMs pathogenesis. First, EIMs arise from an extension of antigen-specific immune responses from the intestine to non-intestinal sites. Second, EIMs are independent inflammatory events initiated or perpetuated by the presence of IBD or by shared genetic or environmental risk factors in the host. These mechanisms are not mutually exclusive and may contribute to varying degrees in different EIMs. Early diagnosis of EIMs contributes to prevention disability and enhancement of quality of life of IBD patients. It is concluded that treatment of extraintestinal manifestations should be carried out taking into account the course of the IBD and the multidisciplinary approach, which requires close cooperation of doctors of various specialties. Assessment of prognostic markers and predictors for EIM in IBD will be part of a future investigation.
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17

Rosen, Theodore, and Tricia J. Brown. "CUTANEOUS MANIFESTATIONS OF SEXUALLY TRANSMITTED DISEASES." Medical Clinics of North America 82, no. 5 (September 1998): 1081–104. http://dx.doi.org/10.1016/s0025-7125(05)70404-1.

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18

Alhassani, Ahmed A., Mohammad S. Al-Zahrani, and Khalid H. Zawawi. "Granulomatous diseases: Oral manifestations and recommendations." Saudi Dental Journal 32, no. 5 (July 2020): 219–23. http://dx.doi.org/10.1016/j.sdentj.2019.12.005.

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19

ATKINSON, JANE C., ANNE O'CONNELL, and DORON AFRAMIAN. "ORAL MANIFESTATIONS OF PRIMARY IMMUNOLOGICAL DISEASES." Journal of the American Dental Association 131, no. 3 (March 2000): 345–56. http://dx.doi.org/10.14219/jada.archive.2000.0178.

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20

Purtilo, David T. "Book ReviewHematologic Manifestations of Childhood Diseases." New England Journal of Medicine 312, no. 14 (April 4, 1985): 929. http://dx.doi.org/10.1056/nejm198504043121429.

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21

Antonelli, Elisabetta, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, and Giovanni Maconi. "Dermatological Manifestations in Inflammatory Bowel Diseases." Journal of Clinical Medicine 10, no. 2 (January 19, 2021): 364. http://dx.doi.org/10.3390/jcm10020364.

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Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature on the dermatologic manifestations occurring in patients with inflammatory bowel diseases has been reviewed. The following dermatological manifestations associated with IBDs have been identified: (i) specific manifestations with the same histological features of the underlying IBD (occurring only in Crohn’s disease); (ii) cutaneous disorders associated with IBDs (such as aphthous stomatitis, erythema nodosum, psoriasis, epidermolysis bullosa acquisita); (iii) reactive mucocutaneous manifestations of IBDs (such as pyoderma gangrenosum, Sweet’s syndrome, bowel-associated dermatosis-arthritis syndrome, aseptic abscess ulcers, pyodermatitis–pyostomatitis vegetans, etc.); (iv) mucocutaneous conditions secondary to treatment (including injection site reactions, infusion reactions, paradoxical reactions, eczematous and psoriasis-like reactions, cutaneous infections, and cutaneous malignancies); (v) manifestations due to nutritional malabsorption (such as stomatitis, glossitis, angular cheilitis, pellagra, scurvy, purpura, acrodermatitis enteropathica, phrynoderma, seborrheic-type dermatitis, hair and nail abnormalities). An accurate dermatological examination is essential in all IBD patients, especially in candidates to biologic therapies, in whom drug-induced cutaneous reactions may assume marked clinical relevance.
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22

Rodriguez, Alejandro, and Jesus S. Vidaurri-Leal. "Ocular manifestations of systemic granulomatous diseases." Current Opinion in Ophthalmology 2, no. 2 (April 1991): 181–89. http://dx.doi.org/10.1097/00055735-199102020-00013.

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23

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 3, no. 2 (April 1992): 273–78. http://dx.doi.org/10.1097/00055735-199204000-00019.

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24

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 4, no. 6 (December 1993): 120–24. http://dx.doi.org/10.1097/00055735-199304060-00018.

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25

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 4, no. 6 (December 1993): 120–24. http://dx.doi.org/10.1097/00055735-199312000-00018.

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26

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 6, no. 6 (December 1995): 104–7. http://dx.doi.org/10.1097/00055735-199512000-00018.

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27

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 7, no. 6 (December 1996): 96–98. http://dx.doi.org/10.1097/00055735-199612000-00016.

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28

Mansour, Ahmad M. "Ocular manifestations of various systemic diseases." Current Opinion in Ophthalmology 8, no. 6 (December 1997): 85–87. http://dx.doi.org/10.1097/00055735-199712000-00015.

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29

Khairallah, Moncef, and Rim Kahloun. "Ocular manifestations of emerging infectious diseases." Current Opinion in Ophthalmology 24, no. 6 (November 2013): 574–80. http://dx.doi.org/10.1097/icu.0b013e3283654e09.

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30

Baker, Robert, and Alimuddin Zumla. "The cutaneous manifestations of mycobacterial diseases." Clinical Microbiology and Infection 4, no. 8 (August 1998): 460–63. http://dx.doi.org/10.1111/j.1469-0691.1998.tb00395.x.

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31

Pierce, Jenny L. "Laryngeal Manifestations of Autoimmune Diseases." Perspectives of the ASHA Special Interest Groups 5, no. 2 (April 24, 2020): 439–56. http://dx.doi.org/10.1044/2020_persp-19-00168.

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Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.
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32

Abraham, S. "Hepatic manifestations of autoimmune rheumatic diseases." Annals of the Rheumatic Diseases 63, no. 2 (February 1, 2004): 123–29. http://dx.doi.org/10.1136/ard.2002.001826.

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33

Shulpekova, Julia O., E. N. Shirokova, V. Yu Rusyaev, and I. V. Damulin. "NEUROLOGICAL MANIFESTATIONS OF PRIMARY CHOLESTATIC LIVER DISEASES." Medical Journal of the Russian Federation 24, no. 4 (August 15, 2018): 213–19. http://dx.doi.org/10.18821/0869-2106-2018-24-4-213-219.

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The most typical and early signs of primary cholestatic liver diseases are represented by itching, prominent asthenia and autonomic dysfunction. These abnormalities significantly affect the quality of life. The data obtained relate itching and asthenic syndrome in cholestatic liver diseases to pathological changes of the central nervous system (CNS). The special scales for assessment of severity of asthenic manifestations, itching and quality of life in primary biliary cholangitis were developed. Besides, memory defects and loss of concentration ability are quite often seen even in non-cirrhotic patients. These defects have a tendency to progress without obvious associations with biochemical and histological parameters of liver disease severity. Some investigators underline the association of asthenic and cognitive disorders with autonomic dysfunction, systolic hypotension and impaired brain perfusion. The origin of itching in cholestatic liver diseases is largely attributed to central nociceptive sensitization and an increased tone of endogenous opiate system. Pathogenetic mechanisms of CNS dysfunction in non-cirrhotic patients with cholestatic diseases may involve neuroinflammation, hypovitaminosis D and E, influence of secondary hyperparathyroidism and exсessive bile acids concentration in blood.
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34

Elston, Dirk M. "Update on Cutaneous Manifestations of Infectious Diseases." Medical Clinics of North America 93, no. 6 (November 2009): 1283–90. http://dx.doi.org/10.1016/j.mcna.2009.08.009.

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35

Schlosser, Bethanee J., Megan Pirigyi, and Ginat W. Mirowski. "Oral Manifestations of Hematologic and Nutritional Diseases." Otolaryngologic Clinics of North America 44, no. 1 (February 2011): 183–203. http://dx.doi.org/10.1016/j.otc.2010.09.007.

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36

Yang, Catherina, and John P. Bent. "Book Review: Laryngeal Manifestations of Systemic Diseases." Annals of Otology, Rhinology & Laryngology 129, no. 4 (November 12, 2019): 412. http://dx.doi.org/10.1177/0003489419888635.

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37

Ruprecht, Klaus W. "Ocular manifestations of congenital and metabolic diseases." Current Opinion in Ophthalmology 2, no. 2 (April 1991): 205–11. http://dx.doi.org/10.1097/00055735-199102020-00016.

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38

Kramer, Theresa, and Hans E. Grossniklaus. "Ocular manifestations of fungal and parasitic diseases." Current Opinion in Ophthalmology 2, no. 2 (April 1991): 212–20. http://dx.doi.org/10.1097/00055735-199102020-00017.

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39

Diamond, Gary R. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 3, no. 2 (April 1992): 215–20. http://dx.doi.org/10.1097/00055735-199204000-00012.

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40

Diamond, Gary. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 4, no. 6 (December 1993): 75–82. http://dx.doi.org/10.1097/00055735-199304060-00012.

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41

Diamond, Gary. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 4, no. 6 (December 1993): 75–82. http://dx.doi.org/10.1097/00055735-199312000-00012.

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42

Diamond, Gary. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 5, no. 6 (December 1994): 72–78. http://dx.doi.org/10.1097/00055735-199412000-00012.

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43

Diamond, Gary R. "Ocular manifestations of genetic and development diseases." Current Opinion in Ophthalmology 6, no. 6 (December 1995): 70–76. http://dx.doi.org/10.1097/00055735-199512000-00012.

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44

Hertle, Richard W. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 7, no. 6 (December 1996): 72–79. http://dx.doi.org/10.1097/00055735-199612000-00012.

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45

Hertle, Richard W. "Ocular manifestations of genetic and developmental diseases." Current Opinion in Ophthalmology 8, no. 6 (December 1997): 66–73. http://dx.doi.org/10.1097/00055735-199712000-00012.

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46

Horak, Pavel, Andrea Smrzova, Karel Krejci, Tomas Tichy, Josef Zadrazil, and Martina Skacelova. "Renal manifestations of rheumatic diseases. A review." Biomedical Papers 157, no. 2 (June 21, 2013): 98–104. http://dx.doi.org/10.5507/bp.2013.042.

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47

Iordan-Dumitru, Andreea Dona, and Rodica Luca. "Oral manifestations of genetic and congenital diseases." Romanian Journal of Stomatology 61, no. 1 (March 31, 2015): 107–11. http://dx.doi.org/10.37897/rjs.2015.1.21.

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Aim. Highlighting the oral manifestations seen in various genetic syndromes and congenital patients hospitalized in a pediatric hospital in Bucharest (Romania). Methods. Retrospective study using medical records of pediatric patients (age = 1 day – 18 years) admitted for a period of three years (1.01.2010-31.12.2012). We selected only the medical records of patients diagnosed with genetic disorders and birth defects (GDD) of which were selected diseases that were associated with oral manifestations (OM). Were established for the whole lot and, separately, for each year: OM disease prevalence, age of first hospitalization, type OM, OM distribution by gender. Data were processed with the program Informatic Hypocrate/DRG. Results. Out of the 25213 hospitalized patients, 2216 (8, 78%) have GDD, between that 78 (3.51%) have been associated with OM. Anual distribution: 2010 – 9226 hospitalized patients, 730 (7.91%) GDD, between that 28 (3.83%) with OM; 2011 – 8,136 hospitalized patients, 769 (9.45%) GDD, between that 23 (2.99%) with OM; 2012 – 7,851 hospitalized patients, 717 (9.13%) GDD, between that 27 (3.76%) with OM. At 36 (46.15%) among patients with OM associated with GDD, age at first hospitalization was between one day-one year. The most frequent cases (23.07%) was cleft lip or palate and was associated with facial dysmorphism and mental retardation. In 20.51% of cases were associated with dental Anomalies of number and structure, in 11, 53% cases – Dental Anomalies of shapes, in 8.97% cases of micro/macroglossia. In a few cases met: mandibular hypoplasia and mucocutaneous. There were no differences between the two sexes. Conclusions. A great variety of OM was found in about 3.51% of hospitalized patients with GDD. Most of them were cleft lip or palate and required multidisciplinary intervention at very early age.
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48

Meldrum, Melissa L., Ramsay S. Kurban, C. Stephen Foster, Daniel M. Albert, and Joan M. O’Brien. "Collagen Vascular Diseases: Cutaneous Manifestations in Ophthalmology." Ophthalmic Plastic and Reconstructive Surgery 16, no. 6 (November 2000): 459–70. http://dx.doi.org/10.1097/00002341-200011000-00011.

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49

Pereira, Paula R., Ronaldo M. Bianchi, Márcia E. Hammerschmitt, Raquel A. S. Cruz, Kivia L. Hesse, Luciana Sonne, Saulo P. Pavarini, and David Driemeier. "Primary skin diseases and cutaneous manifestations of systemic diseases in swine." Pesquisa Veterinária Brasileira 40, no. 8 (August 2020): 579–88. http://dx.doi.org/10.1590/1678-5150-pvb-6704.

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ABSTRACT: Skin diseases in pigs can negatively impact the production. They cause losses related to the death of the affected pigs, to the cost with the treatment, growth retardation and condemnations in the slaughterhouses. This study was developed to determine the frequency and describe the histopathological findings of skin diseases in pigs in different age groups through a retrospective study from 2006 to 2018. A total of 154 conclusive cases were analyzed, including skin restricted diseases (allergic dermatitis, exudative epidermitis, vesicular dermatitis, pityriasis rosea, swinepox, follicular cyst, papilloma and scrotal hemangioma) or skin lesions secondary to systemic diseases (erysipelas, porcine dermatitis and nephropathy syndrome (PDNS), bacterial septicemia and multiple hemorrhages without definite cause). The skin lesions were classified as bacterial (46.1%), viral (26.6%), allergic (12.3%), neoplastic (1.3%) and others (13.6%). Swine erysipelas was the most frequent diagnosis (47/154), followed by PDNS (23/154), allergic dermatitis (19/154) and exudative epidermitis (15/154). Vesicular dermatitis (9/154), pityriasis rosea (9/154), septicemia with cutaneous manifestations (9/154), swinepox (9/154) and multiple hemorrhages without definite cause (7/154) were also observed. Follicular cyst (3/154), hyperkeratosis without definite cause (2/154), papilloma (1/154), and scrotal hemangioma (1/154) were less frequently described. Of the conclusive diagnosis, age was reported in 138 cases, with the highest frequency of skin lesions observed at the inspection process during slaughter (56/138).
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50

Li, Z. X., F. P. Ji, and Z. H. Peng. "PP-225 Skin manifestations in liver diseases." International Journal of Infectious Diseases 15 (July 2011): S107. http://dx.doi.org/10.1016/s1201-9712(11)60375-5.

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