Relevant bibliographies by topics / Ocimum sanctum

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Academic literature on the topic 'Ocimum sanctum'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 September 2023

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Journal articles on the topic "Ocimum sanctum"

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Nithyanandham Masilamani and Dhanraj Ganapathy. "Awareness about Anti-microbial Applications of Ocimum sanctum Herb." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 17, 2020): 740–43. http://dx.doi.org/10.26452/ijrps.v11ispl3.3013.

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Ocimum sanctum happens to be an aromatic shrub belonging to the basil family Lamiaceae.This herb has originated in central India and grown throughout the eastern part of the world. Ocimum sanctum is recommended as a treatment for a wide range of both infectious and non-infectious diseases. This survey was performed for assessing the awareness about antimicrobial applications of Ocimum sanctum herb. A cross-sectional study was done with a self-administered questionnaire with ten questions circulated among 100 dental students. The questionnaire assessed the awareness about Ocimum sanctum therapy in medical applications, their anti-microbial, anti-bacterial, anti-viral, anti-fungal, anti-parasitic and anti-ulcer activity. The responses were recorded and analysed.83% of the respondents were not aware of anti-microbial applications of Ocimum sanctumtherapy .74% were not aware of anti-bacterial properties of Ocimum sanctumtherapy .85% were not aware of anti-fungal properties of Ocimum sanctum therapy. 69% were not aware of the anti-viral properties of Ocimum sanctum therapy. 73% were not aware of anti-parasitic activity Ocimum sanctum therapy. 76% were not aware of anti-ulcer activity of Ocimum sanctum. The awareness about the use of Ocimum sanctum therapy in antimicrobial applications is low among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications, can further enhance knowledge and awareness about Ocimum sanctum therapy.
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A. M. Abdul Ghaffar, Hadeer, Ashraf A. A.Elkomy, and Enas A.H. Farag. "Hepatorenal protective effect of ocimum sanctum in chickens toxicated by gentamicin." International Journal of Pharmacology and Toxicology 9, no. 1 (March 19, 2021): 50. http://dx.doi.org/10.14419/ijpt.v9i1.31421.

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Background: ocimum sanctum (Tulsi) “Queen of herbs” is considered as sacred and medicinal plant in a lot of countries around the world especially India. Therefore this study was carried out to investigate the heptorenal protective effect of ocimum sanctum aqueous extract against gentamicin induced hepatorenal toxicity in chickens.Materials and Methods: A total 100, one-day old unsexed broiler chicks of a commercial breed (Cobb breed) were used in this study, the chickens were subjected to different treatments blood and tissue samples were collected at 5th week of age post administration, biochemical and histopathological examinations were utilized to investigate protective effect of ocimum sanctum aqueous extract on liver and kidney.Results: gentamicin recorded significant (P<0.05)increase in serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and creatinine levels when compared with control group, the administration of ocimum sanctum aqueous extract with gentamicin ameliorate their toxic effect, the group treated with ocimum sanctum aqueous extract only similar to control, while gentamicin induce significant (P<0.05)decrease in serum albumin, total protein and globulin levels when compared with control group, ocimum sanctum aqueous extract with gentamicin restore their toxic effect. The group treated with ocimum sanctum aqueous extract only as control. Gentamicin induce histopathological alterations in liver and kidney tissues by comparison with control group and ocimum sanctum aqueous extract treated group as control, while the administration of ocimum sanctum aqueous extract with gentamicin showing improvement in histopathological lesion compared with toxic effect induced by gentamicin.Conclusions: The hepatotoxicity and nephrotoxicity induced by gentamicin were ameliorated by aqueous extract of ocimum sanctum especially at dose of 2ml/liter in drinking water for 12 days.
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Ramamurthy, Jaiganesh. "Anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum intra oral gel for combating periodontal diseases." Bioinformation 16, no. 12 (December 31, 2020): 1026. http://dx.doi.org/10.6026/973206300161026.

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It is of interest to evaluate the anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum (an Indian herb, Thulsi) intra oral gel in combating periodontal diseases. Hence, 2% of O. sanctum gel was prepared with Carbopol940 soaked in purified water containing 0.2% w/v sodium benzoate overnight. Hydroxy proplyl methyl cellulose (HPMC) solution was mixed with propylene glycol using using tissue homogenizer. Anti-oxidant effect was analyzed using DPPH radical assay and anti-inflammatory effect was assessed using the inhibition of albumin denaturation assay. Ocimum sanctum gel with various dilutions from10 micro litres to 50 micro litres showed exponential increase in percentage of inhibition from 60.9 to 72.2 exhibiting antioxidant activity. The anti-inflammatory effect of Ocimum sanctum gel showed comparatively equivalent effect with standard diclofenac gel with values ranging from 76.6 for 50 micro liters of Ocimum sanctum gel and 89.6 for standard gel at 50 micro liters. Ocimum sanctum showed less toxicity towards brine shrimp nauplii. Thus we show that Ocimum sanctum gel showed potent anti-oxidant and anti-inflammatory effect and less toxic to brine shrimp nauplii as a promising agent for the treatment of periodontal diseases.
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Ramamurthy, Jaiganesh. "Anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum intra oral gel for combating periodontal diseases." Bioinformation 16, no. 12 (December 31, 2020): 1026. http://dx.doi.org/10.6026/973206300161026.

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It is of interest to evaluate the anti-inflammatory, anti-oxidant effect and cytotoxicity of Ocimum sanctum (an Indian herb, Thulsi) intra oral gel in combating periodontal diseases. Hence, 2% of O. sanctum gel was prepared with Carbopol940 soaked in purified water containing 0.2% w/v sodium benzoate overnight. Hydroxy proplyl methyl cellulose (HPMC) solution was mixed with propylene glycol using using tissue homogenizer. Anti-oxidant effect was analyzed using DPPH radical assay and anti-inflammatory effect was assessed using the inhibition of albumin denaturation assay. Ocimum sanctum gel with various dilutions from10 micro litres to 50 micro litres showed exponential increase in percentage of inhibition from 60.9 to 72.2 exhibiting antioxidant activity. The anti-inflammatory effect of Ocimum sanctum gel showed comparatively equivalent effect with standard diclofenac gel with values ranging from 76.6 for 50 micro liters of Ocimum sanctum gel and 89.6 for standard gel at 50 micro liters. Ocimum sanctum showed less toxicity towards brine shrimp nauplii. Thus we show that Ocimum sanctum gel showed potent anti-oxidant and anti-inflammatory effect and less toxic to brine shrimp nauplii as a promising agent for the treatment of periodontal diseases.
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Borhanuddin, Md. "Study of Antihypertensive effects of Ocimum sanctum." Bangladesh Journal of Medical Science 15, no. 3 (November 3, 2016): 357–61. http://dx.doi.org/10.3329/bjms.v15i3.30189.

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Background: Ocimum sanctum is a well reputed medicinal herb being used in the treatment of various ailments in this Indo Pak Subcontinents since ancient time.Methods: In this study the Antihypertensive effects of water extract of Ocimum sanctum and Water soluble fraction of methanol extract of Ocimum sanctum were tried for its antihypertensive effects on albino rats. Extracts were administered via vein and BP was recorded in the carotid artery by direct invasive method.Result: Normal blood pressure was 81/71 mm of Hg (mean blood pressure was 75 mm of Hg. Water extract of Ocimum sanctum has got significant antihypertensive effect (19-30 %). Water soluble fraction of methanol extract of Ocimum sanctum has also got significant antihypertensive effect (15-27 %).Bangladesh Journal of Medical Science Vol.15(3) 2016 p.357-361
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Amelia Niwele, Aulia Debby Pelu, and Laitupa Hardiyanti L. "Uji Aktivitas Antibkteri Ekstrak Etanol Daun Kemangi (Ocium Sanctum L) Asal Desa Ureng Kabupaten Maluku Tengah Terhadap Pertumbuhan Bakteri Staphylococcus epidermis." Jurnal Kesehatan Amanah 5, no. 2 (October 20, 2021): 60–69. http://dx.doi.org/10.57214/jka.v5i2.139.

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One of the plants that can use drugs is the (Ocimum Sanctum Linn). Basil leaves are one of the many available and readily available natural plants in Asia such as Indonesia.In addition to using it as fly,basil leaves are used as bronchitis,malaria,diarrhoea,skin disease,and so on.Studies have been conducted on the test of the leaf’s antibacterial ethanol (Ocimum Sanctum Linn) for the growth of the staphylococcus epidermis bacteria by using the diffusion method for the commonwealth.The study is to identify the extract of basil leaf ethanol (Ocimum Sanctum Linn) that gives resistance to bacteria. Basil leaves (Ocimum Sanctum Linn) in extraction by means 0f a 96% ethanol solducer. The results of the extraction are then in the screening of antibacterial activity at a concentration 25%,50%,and 100%. Tests obtained indicate that ethanol extract is 96% of basil leaves (Ocimum Sanctum Linn) cannot prevent the growth of the staphylococcus epidermis bacteria. The false factor derived from the powdered leaf ethanol extract (Ocimum Sanctum Linn) is influenced by mildew suspension,milquetide exposure to media,incubation temperatures,incubation times,media thickness,and media composition.
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M., Vinaya, Kudagi B. L., Mohammed Ameeruddin Kamdod, and Mallikarjuna Swamy. "Bronchodilator activity of Ocimum sanctum Linn. (tulsi) in mild and moderate asthmatic patients in comparison with salbutamol: a single-blind cross-over study." International Journal of Basic & Clinical Pharmacology 6, no. 3 (February 24, 2017): 511. http://dx.doi.org/10.18203/2319-2003.ijbcp20170543.

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Background: Bronchial asthma is one of the commonest chronic inflammatory diseases. The drugs available to treat bronchial asthma such as, beta-2 agonists, though very effective are associated with adverse effects. Therefore, the Ocimum sanctum (Tulsi) which was shown to have antiasthmatic activity in Ayurveda, is evaluated in this study.Objectives: To evaluate the bronchodilator activity of Ocimum sanctum Linn. in mild and moderate asthma and compare its efficacy with the standard bronchodilator drug, Salbutamol.Methods: This is a single-blind cross-over study. Capsules of Ocimum sanctum Linn. (200 mg, twice daily) and Salbutamol sulphate (2 mg, twice daily) were administered in 41 patients. Each drug was administered for a period of one week with a washout period of one week between the two drug schedules. FEV1 and PEFR were recorded in these patients to assess the bronchodilator activity before the drug administration, on 4th and on 7th day of administration of Ocimum sanctum and the parameters obtained were compared with that of the standard drug, Salbutamol.Results: Ocimum sanctum 200mg twice daily produced significant improvement in both FEV1 and PEFR values, on 4th and 7th day and also produced improvement in symptoms of asthma. On comparing the results with that of Salbutamol 2mg twice daily, the bronchodilator activity of Ocimum sanctum was found to be less efficacious, where Salbutamol produced very highly significant improvement in FEV1 and PEFR values on both 4th and 7th day.Conclusions: Our results suggest that Ocimum sanctum Linn. possesses significant bronchodilator activity in mild and moderate bronchial asthma.
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Nababan, Evalentina, and Hasruddin Hasruddin. "The Effect Of Giving Ocimum sanctum L. Leaf Extract On Growth Of Bacteria Bacillus cereus." JURNAL BIOSAINS 1, no. 2 (January 9, 2016): 51. http://dx.doi.org/10.24114/jbio.v1i2.2787.

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The aim of this research is to know the effect giving Ocimum sanctum L. leaf extract on growth of bacteria Bacillus cereus. This research has been done in microbiology laboratory FMIPA UNIMED in March 2015. The design of experiment of this research is Random Sampling Non Factorial with six concentrations Ko = 0%, K1 = 2%, K2 = 4%, K3 = 6%, K4 = 8% dan K5 = 10%. The parameter observed of bacteria Bacillus cereus for 48 hours by calculating blocked zone diameter with incubation period 1 x 24 hours and 2 x 24 hours. The result of the research data shows that different concentration of Ocimum sanctum L. effect on the blocked zone diameter of Bacillus cereus growth. The largest blocked zone diameter is 12,9 mm which is produced by 10% concentration of Ocimum sanctum L. leaf extract with incubation time 2 x 24 hours and the smallest blocked zone diameter is 4,7 mm which is produced by 2% concentration of Ocimum sanctum L. leaf extract with incubation time 2 x 24 hours. Key words: Etanol, Ocimum sanctum L. leaf, Bacillus cereus.
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Bhattacharyya, Piyali, and Anupam Bishayee. "Ocimum sanctum Linn. (Tulsi)." Anti-Cancer Drugs 24, no. 7 (August 2013): 659–66. http://dx.doi.org/10.1097/cad.0b013e328361aca1.

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Nurani, Neng Vera, and Neily Zakiyah. "Artikel Ulasan: Aktivitas Ekstrak Tanaman Ocimum sp. terhadap Streptococcus mutans Penyebab Karies Gigi." Indonesian Journal of Biological Pharmacy 2, no. 3 (December 27, 2022): 171. http://dx.doi.org/10.24198/ijbp.v2i3.39911.

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Karies gigi termasuk salah satu penyakit gigi dan mulut yang paling umum terjadi pada manusia. Penyebab umum dari karies gigi ini disebabkan oleh bakteri gram positif Streptococcus mutans. Karies gigi dapat dicegah dengan menyikat gigi dan pemberian antibakteri. Tanaman tradisional telah terbukti menjadi sumber yang lebih baik dalam pencarian senyawa antibakteri baru. Tanaman herbal yang mempunyai potensi antibakteri diantaranya yaitu kemangi (Ocimum sp.) yang tumbuh subur di Indonesia. Terdapat beberapa jenis tanaman Ocimum sp. diantaranya Ocimum basilicum, Ocimum americanum, dan Ocimum sanctum. Penelitian ini dilakukan dengan metode literature review. Ketiga jenis ekstrak Ocimum memiliki potensi sebagai antibakteri terhadap Streptococcus mutans. Ekstrak Ocimum basilicum mempunyai aktivitas antibakteri sedang sampai kuat dengan nilai zona hambat 6,9-10,26 mm, ekstrak Ocimum americanum memiliki zona hambat kuat sebesar 17,5 mm dan ekstrak Ocimum sanctum memiki zona hambat kuat-sangat kuat sebesar 12-22 mm. Diantara 3 jenis Ocimum sp., ekstrak Ocimum sanctum pada pelarut etanol 100% yang diuji dengan metode sumuran mempunyai aktivitas dan efektivitas paling kuat untuk menghambat Streptococcus mutans dengan nilai zona hambat 22 mm.
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Dissertations / Theses on the topic "Ocimum sanctum"

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Malapermal, Veshara. "In vitro antidiabetic and antimicrobial properties of Ocimum species (Ocimum basilicum and Ocimum sanctum) (L.)." Thesis, 2016. http://hdl.handle.net/10321/1534.

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Submitted in fulfillment of the requirements of the degree of Master in Technology, Department of Biomedical Technology and Clinical Technology, Durban University of Technology, Durban, South Africa, 2016.
Introduction In Africa, use of phytotherapy for treatment of diabetes mellitus is a common form of practice. Considering the increasing burden of non-communicable diseases in South Africa efforts are directed at simple, cost effective, non-hazardous and efficient methods to treat cancer, cardiovascular diseases and diabetes. The role of phytonanotherapy is an attractive proposition for advancing new therapies. Metal nanoparticles are a possible means for delivery of such therapies. However, this requires investigation on interactions, mechanisms and therapeutic efficacy upon co-administering ethnobotanicals with metal nanoparticles and existing drug therapy in human beings. Aim The primary aim of the study was to test the in vitro antidiabetic and antibacterial activity of Ocimum sanctum (leaf extracts and flower extracts), Ocimum basilicum (leaf extracts and flower extracts), and a combination of the leaf extracts of both, and to observe whether any antidiabetic and antibacterial activity was enhanced in due to phyto-synthesised bimetallic gold-silver (Au-Ag) nanoparticles and silver nanoparticles. Methods Aqueous and ethanol extracts of O. sanctum and O. basilicum leaf and flowers alone and combined (leaf + flower) were prepared using hot vs cold water extraction techniques and 60% and 70% ethanol as polar solvents. A simple, rapid, cost effective and reproducible green chemistry method synthesised alloyed bimetallic (Au-Ag) nanoparticles using O. basilicum leaf and flower aqueous extracts and prepared silver nanoparticles (AgNps) using O. basilicum and O. sanctum leaf aqueous extracts singly and in combination (O. sanctum + O. basilicum). The size, shape and elemental analysis of the nanoparticles was carried out using UV-Visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy coupled with energy-dispersive X-ray (SEM-EDX), dynamic light scattering (DLS) and zeta potential. Fourier transform infrared spectroscopy (FT-IR) supported by gas chromatography mass spectroscopy (GC-MS) identified the bio-capping agents. Antidiabetic carbohydrate metabolising enzymes, α-amylase (porcine) and Bacillus stearothermophilus α-glucosidase as models tested the in vitro inhibitory potential of the aqueous and ethanol plant extracts and the phyto-synthesised (Au-Ag) bimetallic and AgNps. In addition, the study investigated the antibacterial potential for the aqueous plant preparations and their respective phyto-synthesised bimetallic and AgNps against the bacterial species Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella species and Pseudomonas aeruginosa compared to gentamycin and vancomycin. Results Bimetallic nanoparticles (synthesised from leaf and flower aqueous extracts) displayed inhibitory activity that showed uncompetitive inhibition (leaf extract), and non-competitive inhibition (flower extract) of α-amylase and competitive (leaf extract) and uncompetitive inhibition (flower extract) of α-glucosidase. Bimetallic nanoparticles were higher in inhibitory activity than acarbose and the crude O. basilicum ethanol and aqueous leaf and flower extracts. In the antibacterial analysis, bimetallic nanoparticles derived from O. basilicum leaf showed inhibition against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa and were greater in activity compared to the crude aqueous leaf extract from O. basilicum. The in vitro inhibitory effect of AgNps derived from O. sanctum and AgNps derived from O. basilicum on both enzymes was higher in activity than acarbose and their respective crude extracts. However, in combination (O. sanctum + O. basilicum), the derived AgNps appeared to be a less potent inhibitor of α-amylase and α-glucosidase enzyme and was lower than acarbose. AgNps synthesised from the combination of O. sanctum and O. basilicum showed the highest percentage inhibition against Bacillus stearothermophilus α-glucosidase, and AgNps derived from O. sanctum and AgNps derived from O. basilicum displayed competitive type of inhibition. In the antibacterial analysis, AgNps derived from the various extracts showed zones of inhibition against the Gram negative and Gram positive bacterial test strains. However, AgNps synthesised from the O. sanctum leaf extract showed higher inhibition against Escherichia coli than the positive control gentamycin and higher inhibition against Staphylococcus aureus compared to vancomycin. In addition, AgNps from O. sanctum leaf extract displayed inhibition against Bacillus subtilis, Pseudomonas aeruginosa and Salmonella species, thus representing the highest antibacterial potential. Conclusion The results demonstrate the possibility of synthesis of stable silver and bimetallic nanoparticles of Ocimum sp. The synthesised silver nanoparticles and first time synthesis of bimetallic (Au-Ag) nanoparticles displayed enhanced antihyperglycaemic properties compared to their respective crude extracts and, therefore, show promising effects in lowering postprandial hyperglycaemia in diabetic patients with dual potential for antibacterial treatment. However, the antidiabetic and antibacterial effect will need to be further affirmed in a clinical context. Medicinal plants with therapeutic value may create a new platform for further research to explore the potential for herbal medicine and nanoscience as effective biomedical and industrial applications, and for improving existing drug delivery systems in diabetic patients. Investigations into the cytotoxicity of these extracts and phytosynthesised nanoparticles is recommended.
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SAKSHI and SARIKA YADAV. "A COMPREHENSIVE REVIEW ON PHYTOCHEMICAL EVALUATION AND PHARMACOLOGICAL ACTIVITIES OF OCIMUM SANCTUM." Thesis, 2023. http://dspace.dtu.ac.in:8080/jspui/handle/repository/19862.

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Tulsi is often regarded as “the incomparable one”, “Elixir of life” and Queen of herbs”. Tulsi is being used for about a thousand years to support a healthy mind, body, and spirit. Tulsi is believed to have originated in northern central India but grows throughout the Indian subcontinent, Nepal, Bangladesh and much of Southeast Asia. Across different cultures, it is a symbol of purity. It is used to treat various types of diseases and disorders from ancient times. It has tremendous medicinal properties and is used to treat heart diseases, digestive issues, respiratory problems, menstrual cramps, skin related disorders like acne, and mouth ulcers and even helps in controlling blood sugar levels. It is significantly used as an immune-modulatory, antihypertensive, antioxidant, antipyretic, antimicrobial and for anticancer activity. Phytochemicals like Eugenol, methyl eugenol, anthocyanins, linalool, ursolic acid are accountable for the pharmacological properties of the Tulsi. In this report we will discuss about the different varieties of Tulsi, its classification, traditional uses, it’s phytochemicals constitution and the pharmacological activities
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Sarvaiya, Sushil R. "Studies on hypertension with special references to hypotensive effect of ocimum sanctum." Thesis, 1986. http://hdl.handle.net/2009/5067.

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Silva, Luis Hernan Giraldo Silva. "Production of secondary metabolites in cell suspension cultures of Ocimum sanctum L." Master's thesis, 2015. http://hdl.handle.net/1822/39739.

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Dissertação de mestrado em Plant Molecular Biology, Biotechnology and Bioentrepreneurship
The Ocimum sanctum belongs to the Labiatae family. Commonly known for their medicinal and therapeutic potential, traditionally used to treat rheumatism, paralysis, epilepsy, colds, flu, high fever, influenza, abdominal pains, coughs and others symptomologies. O. sanctum is often described as a “Rasayana” (plant with adaptogenic properties), it is regarded in Ayurveda as a “elixir of life” and believed to promote longevity. Several investigators have reported that O. sanctum possess numerous biological activities mostly related with enzymatic and non-enzymatic antioxidant mechanisms and the capability of maintain body homeostasis and resistance to different stress due their phenolic compounds constituents, namely rosmarinic acid. The objectives of this study were: 1) increase rosmarinic acid and phenolics production trough elicitation techniques in cell suspension cultures; 2) evaluate the in vitro antiradical properties of these extracts; 3) Incorporate the extract into a cream base and evaluate its in vitro antioxidant properties. O. sanctum cell suspension cultures were treated with several elicitors in order to increase phenolic compounds production and accumulation (mainly rosmarinic acid); phenolic quantification of cell extracts and in vivo leaf extracts were analyzed by (HPLC-DAD). O. sanctum cell suspension cultures were able to produce 93% more rosmarinic acid than in vivo plants; In vitro radical properties of the extracts were analyzed trough DPPH, iron chelating activity, inhibition of nitric oxide production and scavenging of superoxide anion. O. sanctum cell suspension cultures extracts have shown antiradical scavenging activity for the non-enzymatic assays tested in the present study displaying high potential to inhibit the nitric oxide production and superoxide anion, avoiding their interaction and preventing the formation of ONOO−; contrary to pure rosmarinic acid, cell extracts can also chelate iron ions decreasing the formation of hydroxyl groups produced by the Fenton reaction; cell suspension extracts also displayed high DPPH scavenging potential and may act as chain breaking antioxidants. After having performed tests on the antioxidant activities O. sanctum in extracts, a portion of it was included successfully in a cream base in order to evaluate the antioxidant capacities in order to determine their ability to perform next test in rats.
A espécie Ocimum sanctum pertence à família Labiatae. Conhecido pelo seu potencial medicinal e terapêutico, é tradicionalmente utilizado no tratamento do reumatismo, paralisia, epilepsia, constipações, gripe, febres altas, dores abdominais, tosse e outras sintomatologias. O. sanctum é descrita como uma “Rasayana”, isto é, uma planta com propriedades adaptogénicas, e é conhecida pela medicina tradicional Ayurveda como sendo o “elixir da vida” e por aumentar a longevidade. Vários investigadores demonstraram que O. sanctum possui várias atividades biológicas, maioritariamente relacionadas com mecanismos antioxidantes enzimáticos e não enzimáticos e, também, a capacidade de manter a homeostasia e a resistência do corpo a diferentes tipos de stresse devido ao conteúdo em compostos fenólicos, em particular o ácido rosmarínico. Assim, este estudo teve como principais objetivos: 1) o aumento da produção de ácido rosmarínico e compostos fenólicos bioactivos através da eliciação de culturas celulares em suspensão de O. sanctum; 2) a determinação in vitro das propriedades antiradicalares dos extratos respetivos; e, 3) a incorporação dos extratos num creme e avaliação in vitro das suas propriedades antiradicalares. Culturas celulares em suspensão de O. sanctum foram tratadas com vários eliciadores de forma a aumentar a produção e acumulação de compostos fenólicos, nomeadamente ácido rosmarínico. O conteúdo em compostos fenólicos dos extratos celulares e dos extratos de folhas in vivo foi determinado por HPLC-DAD. As culturas celulares em suspensão de O. sanctum demostraram uma produção de ácido rosmarínico 93% superior à das plantas in vivo. As propriedades antioxidantes dos extratos das culturas celulares de O. sanctum foram avaliadas através do método DPPH, atividade quelante do ferro, inibição da produção de óxido nítrico e remoção do anião superóxido. Os extratos das culturas celulares de O. sanctum demonstraram elevada atividade antioxidante, mostrando um elevado potencial na inibição da produção de óxido nítrico e de superóxido evitando, desta forma, a interação destes e prevenindo a formação de ONOO−. Contrariamente ao ácido rosmarínico puro, os extratos celulares têm também a capacidade de quelar iões de ferro diminuindo a formação de grupos hidroxilo produzidos na reação de Fenton. Estes extratos demonstram, ainda, um elevado potencial de scavenging de DPPH, podendo atuar como antioxidantes devido ao alto conteúdo em compostos fenólicos. Depois de ter realizado testes sobre as actividades antioxidades dos extractos de O. sanctum, uma porção dele foi incluído com sucesso numa base de creme, com objetivo avaliar as capacidades antioxidantes do creme obtido para executar próximo teste em ratos.
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Haibru, V. "Ocimum sanctum: a potential source of anti-cancer agent and its role in restoration of Maspin via Snail and HDACs in Breast cancer." Thesis, 2014. http://ethesis.nitrkl.ac.in/6250/1/E-4.pdf.

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With cancer being a wide spread threat to humanity, plants have an important role in cancer prevention and in therapy. Medicinal plants provide new active chemo-preventive molecules. It is suspected that Ocimum sanctum would be a potent weapon discovered so far in fighting against all kinds of Cancer. There are many HDAC inhibtiors, but they are toxic in nature, this study aim at finding a phytochemical which is less toxic to human. For this ethanolic and methanolic extract of Tulsi leaves and inflorescence were detected to check whether they contain any components that can inactivate HDAC and can activate tumor suppressor genes. Further the anti- proliferative and anti-apoptoic effect of ethanolic and methanolic extract is studied. The role of theses extracts on the expression of tumor suppressor gene (Maspin), transcriptional factor (Snail), and epigenetic modulator (HDAC1, HDAC2) is investigated along with their anti-migratory effects on cancer cells. It is very much clear from the current investigation that the tulsi leaf and inflorescence extracts have the anti-cancer potential. This anti-cancer potential is due to the combinatorial effect of anti-proliferative, apoptotic and anti-migratory effect of the tulsi extracts. It is demonstrated from our experiments that the EETL exert more anti-cancer effect on breast cancer cells than METL and EETI. This investigation also demonstrates the higher efficacy of EENL in restoring the expression of maspin with concurrent enhancement of HDAC-1 and HDAC-2 mRNA levels, and reduced expression of snail. This reflects the HDAC inhibitory activity of tulsi extract.
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Books on the topic "Ocimum sanctum"

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R, Mardikar Bhaskar, and University of Poona. Interdisciplinary School of Ayurvedic Studies., eds. Krishna tulas (Ocimum sanctum), a monograph. Pune: Interdisciplinary School of Ayurvedic Medicine, University of Poona, 1989.

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2

Rai, Yash. Tuḷasa: Koṇatyāhī prakāracyā rogāvara prabhāvī aushadha. 4th ed. Mumbaī: Gālā Pabliśarsa, 1992.

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Brahmadatta, Śarmā. Tulasī. 2nd ed. Vārānaṣī: Kr̥shṇadāsa Akādamī, 1989.

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Brahmadatta, Śarmā. Tulasī. 2nd ed. Vārānaṣī: Kr̥shṇadāsa Akādamī, 1989.

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Nārāyaṇareḍḍi, Pāṭīl. Tulasi pūjā vidhānamu: 40 rōgālaku cikitsa. Tenāli: Sādhana Granthamaṇḍali, 1994.

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Dasa, Amala-bhakta. The life of Tulasī Devī and her care and worship. [United States?]: Nadia Productions, 1997.

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Purohita, Rajanīkānta. Vividha svarūpe Tulasījī. Gāndhīnagara: Saṃskr̥ta Sāhitya Akādamī, 1998.

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Śarmā, Maheśanārāyaṇa, and Rājeśa Kumāra Śarmā. Braja kī Tulasī-kaṇṭhīmālā: Braja meṃ Tulasī kā mahatva, sthānīya loka-paramparā meṃ kaṇṭhī-mālā, Tulasī-kāshṭha se banī kaṇṭhiyoṃ kā vaividhya, Purāṇoṃ sahita sthānīya devālayī alpajñāta-ajñāta dastāvejoṃ meṃ ukta vishayaka ullekha, kaṇṭhiyoṃ ke ākāra-prakāra evaṃ upayogitā para kendrita kārya. Vr̥ndāvana: Vr̥ndāvana Śodha Saṃsthāna, 2012.

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Carbone, John C. Vaisnava goddess as plant: Tulasi in text and context : a study of the sacred Tulasi plant, in Hindu myth and practice. Saarbrücken: VDM, Verlag Dr. Müller, 2008.

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Rai, Yash. Holy basil Tulsi, a herb: A unique medicinal plant. Ahmedabad: Gala Publishers, 1992.

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Book chapters on the topic "Ocimum sanctum"

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Dev, Sukh. "Ocimum sanctum." In Prime Ayurvedic Plant Drugs, 526–36. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-22075-3_76.

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Ocimum sanctum L." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 450. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1426.

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Khare, C. P. "Ocimum sanctum Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1085.

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Sastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Ocimum spp. (Ocimum basilicum and O. sanctum) (Basil, Thulasi)." In Encyclopedia of Plant Viruses and Viroids, 1645–48. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_626.

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Mandal, Ashok Kumar, Madhav Poudel, Netra Prasad Neupane, and Amita Verma. "Phytochemistry, Pharmacology, and Applications of Ocimum sanctum (Tulsi)." In Edible Plants in Health and Diseases, 135–74. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-4959-2_4.

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Venkatachalam, V. V., and B. Rajinikanth. "Immunomodulatory Activity of Aqueous Leaf Extract of Ocimum sanctum." In Recent Advancements in System Modelling Applications, 425–32. India: Springer India, 2013. http://dx.doi.org/10.1007/978-81-322-1035-1_37.

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Kaushal, Naveen, Suresh Rao, Preety Ghanghas, Soniya Abraham, Thomas George, Sueallen D’souza, Jeffey M. Mathew, Jessica Chavali, Mallappa Kumara Swamy, and Manjeshwar Shrinath Baliga. "Usefulness of Ocimum sanctum Linn. in Cancer Prevention: An Update." In Anticancer plants: Properties and Application, 415–29. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8548-2_18.

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Das, Manik, Debarshi Kar Mahapatra, and Kuntal Manna. "Ocimum sanctum L. (Holy Basil or Tulsi): A Medicinally Significant Herb." In Applied Pharmaceutical Science and Microbiology, 95–115. Includes bibliographical references and index.: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9781003019565-6.

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Pramanick, Prosenjit, Sufia Zaman, and Abhijit Mitra. "Unique Traditional Approach to Address Human Health Issues with Ocimum sanctum." In Ethnic Knowledge and Perspectives of Medicinal Plants, 275–86. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003352983-11.

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Pasangulapati, Jagadeesh Prasad, Arun Reddy Ravula, Dinesh Reddy Kanala, Shanmukhi Boyina, Kiran Gangarapu, and Hemanth Kumar Boyina. "Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia-Induced Vascular Dementia." In Advances in Experimental Medicine and Biology, 213–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-32633-3_30.

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Conference papers on the topic "Ocimum sanctum"

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Kurniasih, Nunung, Muhamad Latief, Asep Supriadin, and Assyifa Junitasari. "Antioxidant activity of essential oil from basil (Ocimum sanctum L.)." In PROCEEDINGS OF THE SYMPOSIUM ON ADVANCE OF SUSTAINABLE ENGINEERING 2021 (SIMASE 2021): Post Covid-19 Pandemic: Challenges and Opportunities in Environment, Science, and Engineering Research. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0113911.

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Ali Mezeal, Intesar, Ghanyia Jasim Shanyoor, and Sabreen Ali Mezil. "Description, Antifungal Activities Designed for Ocimum sanctum in Green Produced Silvery Nanoparticles." In المؤتمر العلمي الدولي العاشر. شبكة المؤتمرات العربية, 2019. http://dx.doi.org/10.24897/acn.64.68.484.

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Nagarajan, N., and M. Senthil Kumar. "Queen of herb - Ocimum sanctum Linn (Tulsi) and its medicinal importance – A review." In THIRD VIRTUAL INTERNATIONAL CONFERENCE ON MATERIALS, MANUFACTURING AND NANOTECHNOLOGY. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0096483.

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"Inhibitory Activities of Methanol Extracts of Andrographis Paniculata and Ocimum Sanctum against Dengue-1 Virus." In International Conference on Biological, Environment and Food Engineering. International Institute of Chemical, Biological & Environmental Engineering, 2014. http://dx.doi.org/10.15242/iicbe.c814013.

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"Network pharmacology and molecular docking techniques to elucidate the mechanisms of Ocimum sanctum against tuberculosis." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-204.

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Nurtjahja, Kiki, Albert Pasaribu, and Roslindawati. "The Effect of Basil Leaves Extract (Ocimum sanctum L.) on Mycelial Growth of Postharvest Fungi." In The International MIPAnet Conference on Science and Mathematics (IMC-SciMath). SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0010612700002775.

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"Kualitas Semen Cair Kambing Boer selama Penyimpanan Suhu Ruang dengan Penambahan Ekstrak Daun Kemangi (Ocimum sanctum)." In Teknologi Peternakan dan Veteriner Mendukung Kemandirian Pangan di Era Industri 4.0. Pusat Penelitian dan Pengembangan Peternakan, 2019. http://dx.doi.org/10.14334/pros.semnas.tpv-2019-p.334-344.

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Rubiyanto, Dwiarso, Nadia Mustofa, Dian Novita Sari, Tatang Shabur Julianto, and Is Fatimah. "Fruit fly attractant activity of Indonesian native ruku-ruku (Ocimum sanctum, L.) and selasih ungu (Ocimum canum, Sims.) essential oil formulated with virgin coconut oil (VCO)." In THE 4TH INTERNATIONAL SEMINAR ON CHEMICAL EDUCATION (ISCE) 2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0117904.

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Singhal, Sharad S., Lokesh Nagaprashantha, Jyotsana Singhal, and Sanjay Awasthi. "Abstract 2697: Role of a novel flavonoid enriched in ocimum sanctum linn for prostate cancer chemoprevention and therapy." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2697.

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Rachmawati, Ermin, and Rislan Faiz Muhammad. "The ethanolic extract of holy basil leaves (Ocimum sanctum L.) attenuates atherosclerosis in high fat diet fed rabbit." In INTERNATIONAL CONFERENCE ON LIFE SCIENCES AND TECHNOLOGY (ICoLiST 2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0052561.

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