Journal articles: 'ODBC'

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Lambert, Sherwood Lane, Jon Holladay, and Dawna M. Drum. "International AC: An Education Case on Continuous Monitoring SQL Server Data with ODBC-Linked Tables in Microsoft Access." Journal of Emerging Technologies in Accounting 13, no. 2 (September 1, 2016): 195–213. http://dx.doi.org/10.2308/jeta-51597.

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ABSTRACT This education case teaches students Continuous Auditing/Continuous Monitoring (CA/CM) using Open Database Connectivity (ODBC) connections from students' Microsoft Access (Access) to tables in Microsoft SQL Server (SQL Server). First, the institution's database administrator (DBA) imports the student tables provided with the Teaching Notes into the institution's SQL Server with read-only access. In Access, students create ODBC connections to the SQL Server student tables. Then, students create Access queries using the ODBC-linked tables to monitor for anomalies. During a scheduled week, the DBA, in coordination with the faculty member, enters anomalies in the SQL Server student tables at random times, and students run their Access queries to identify the anomalies.

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Ye, Dan. "Automated Testing Framework for ODBC Driver." Journal of Software Engineering and Applications 04, no. 12 (2011): 688–99. http://dx.doi.org/10.4236/jsea.2011.412081.

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Huang, Bao Hua, Tian Jing Wang, Yan Ma, and Feng Jiang. "Schema of Enhancing User Authentication and Encrypting Lob Data in ODBC Driver for Database." Applied Mechanics and Materials 543-547 (March 2014): 3688–91. http://dx.doi.org/10.4028/www.scientific.net/amm.543-547.3688.

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For commercial database management system is not suitable for storing sensitive data, the data is often encrypted in application before keeping into database. Using UDF (User Defined Function) can simplify the encrypting procedure, but it can't handle Lob (Long object) data. A schema of enhancing user authentication and encrypting Lob data in ODBC (Open Database Connection) driver for database is prosed. By adding necessary attributes of user authentication and cipher algorithm to encrypt Lob data in ODBC driver, the security of data stored in database is improved. Experiments show that the schema is transparent, efficient, easy to implement and reliable.

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Tripathi, Rajesh, Sejin Im, Douglas Devoto, Joshua Major, Sreekant Narumanchi, Paul Paret, and Xuhui Feng. "Power electronics thermal solutions using thermally conductive polyimide films." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2019, DPC (January 1, 2019): 000616–46. http://dx.doi.org/10.4071/2380-4491-2019-dpc-presentation_tp3_042.

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Increased adoption of hybrid and electrical vehicles as well as renewable energy systems are driving the innovation in power module packaging. Thermal substrate, one of the major components of power modules, is not an exception, and technological advancements are necessary to meet increased reliability requirements. DuPont has developed a thermally conductive polymer film that provides very low thermal resistance and very high insulation. The film can be bonded to conductive and thick metallic layers and this polymer equivalent of DBC shows very high reliability in addition to high performance characteristics. Electrically insulating layers within a power electronics module are critical for separating circuitry from thermal management layers. Electrical insulating substrates typically used in power electronics modules utilize a ceramic layer, comprised most commonly of either Al2O3, AlN, or Si3N4. Thin Cu layers are bonded to either side of the substrate using a direct bond Cu (DBC) or active metal brazing (AMB) process. These processes involve bonding metallization layers to both sides of the ceramic at a high temperature as bonding to only one side would cause deformation during the cooling phase. Typical metal thickness bonded to either side of the ceramic is about 0.3–0.6 mm as the high temperature manufacturing process does not allow very thick metals to be bonded and this limits the heat spreading capability of the thermal substrate. DuPont's new Temprion™ Organic Direct Bond Copper (ODBC) address aforementioned problems, increasing thermal durability and reliability as well as enabling system layer suppression. Temprion™ ODBC's dielectric layer will absorb thermo-mechanical stress from the metals due to CTE mismatch, dramatically improving durability of the system. In addition, various kinds of metals including Cu and Al can be easily bonded to Temprion™ DB films through simple process. There are no thickness limitations on bonding metal sheets and metal attached at the bottom can be used as an integrated heat sink/baseplate. Al2O3 and Si3N4-based substrates were utilized as a baseline for reliability comparison with the DuPont substrates. The industry-standard substrates in used in this study have a thickness of 0.3 and 0.8 mm for the Cu metallization layers and 0.38 and 0.32 mm for the insulating layer respectively for Al2O3 an Si3N4 insulators. DuPont ODBC substrates were fabricated by attaching a polyimide layer to a layer of 0.8-mm-thick Cu. The polyimide and bottom Cu layer cross-sectional footprints are both 50.8 mm × 50.8 mm. The corners of both layers were filleted with various radii (0.5, 1.0, 2.0, and reversed 2.0 mm) to explore the impact of different stress concentrations between the metallization and insulating layers. The top Cu metallization was inset 2.0 mm from the perimeter of the electrically-insulating substrate and bottom Cu metallization.10 samples each of the DuPont ODBC and industry Al2O3 substrates were placed in a thermal shock chamber and cycled between temperature extremes of −40°C and 200°C. Substrates were inspected every 1000 cycles. After 5000 cycles, the ODBC substrates experienced no hipot failures, but preliminary edge delamination was visually observed. Al2O3 substrates all failed after 50 thermal cycles.Five DuPont ODBC samples were placed in a thermal chamber and subjected to an elevated temperature of 175°C. After 2000 hours, no hipot failures were observed, but edge delamination was again observed.Five DuPont ODBC samples were attached to a cold plate with Kapton tape. Heater cartridges were attached to the top of the substrates with Kapton tape and thermocouples were placed in several locations through the package. The heater cartridges were alternated between on and off states to allow for the substrates to cycle between −40°C and +200°C. While the change between the maximum and minimum temperatures is smaller for the power cycling test compared to the thermal cycling test, the heater cartridge and cold plate create a thermal gradient within the samples that is not possible with passive thermal cycling. After 2000 hrs cycles of testing, no hipot failures or edge delamination have been observed. Herein we show that the DuPont ODBC substrate design is a promising alternative to traditional industry substrates based on ceramic insulators. The reliability of the substrate design has been demonstrated under several thermomechanical accelerated tests and the electrical and thermal performance has been measured. Future work will include reliability comparisons to other industry substrates, including thermal shock testing of substrates with HPS, AlN, and Si3N4 ceramic layers. Thermal models will correlate thermal resistance values measured by the transient thermal tester and compare the ODBC substrate performance to industry substrates within a commercialized power electronics module. The modeling will also optimize the thickness of the metallization layers within the ODBC substrates to minimize the junction temperature of the switching devices.

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Li, Guang. "A High Speed and Ultra Long-Haul Radio-Over-Fiber System Employing Dual Photoelectric Arms Coherent Modulation and Optical Duo-Binary Coding." Advanced Materials Research 988 (July 2014): 544–47. http://dx.doi.org/10.4028/www.scientific.net/amr.988.544.

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A novel high speed and ultra long-haul radio-over-fiber (ROF) system based on Dual Photoelectric Arms Coherent Modulation (DPACM) and Optical Duo-Binary Coding (ODBC) is proposed, and demonstrated. The signal spectrum bandwidth, generated by ODBC based on the first order DPACM, is half of non-return-to-zero (NRZ ) signal spectrum bandwidth. The secondary order DPACM generates a 40-GHz Millimeter-wave (mm-wave) that is transmitted over fiber (ROF). The simulation results show that, the bit rate can be up to 40 Gbps and the transmission distance is over 1500 Km, based on the ROF system with a 0 dBm continuous-wave laser source, multiple stages Er-Doped Fiber Amplifier (EDFA), a standard single mode fiber (SSMF) with a dispersion of 17 ps/nm/Km and a attenuation of 0.2 dB/Km.

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Zhang, Ying Jie, and Gui Hong Jia. "Development of Mechanical CAD System Based on ARX." Applied Mechanics and Materials 71-78 (July 2011): 3996–99. http://dx.doi.org/10.4028/www.scientific.net/amm.71-78.3996.

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In AutoCAD2008 development platform, taking MFC and ARX as development, integrating MFC ODBC to develop database, combining with parametric drawing techniques, it establishes the basic framework of mechanical CAD system. And taking gears parametric drawing as an example, the key technology of CAD system is illustrated, which improves the design efficiency and shortens the development cycle.

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Li, Hui, Xiao Hong Ge, and Dun Ming Liao. "Development & Application for a Visual Casting Process CAD System of Copper Alloy." Advanced Materials Research 179-180 (January 2011): 534–37. http://dx.doi.org/10.4028/www.scientific.net/amr.179-180.534.

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On the basis of AutoCAD, a visual casting process CAD system for copper alloy, using VC++.NET 2002 and re-development tool ObjectARX, is developed by key technologies including exchanging data between Access and MFC ODBC, graphics preview and real-time rendering. This system also accords with the national casting standards & requirement of a corporation, can realize real-time feedback in casting process design and improve the efficiency and accuracy availably.

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Zhu, Zu Wei, Jue Xiao Chen, and Ze Chang Sun. "SQL Server Access Methods Based on LabVIEW." Applied Mechanics and Materials 596 (July 2014): 914–17. http://dx.doi.org/10.4028/www.scientific.net/amm.596.914.

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Several methods that contribute to connecting SQL server database with LabVIEW are listed and compared in the paper, while the method of using LabSQL is exemplified to show its convenience and reliability. Two steps are required to achieve the connectivity between database and LabVIEW via LabSQL: First is setting up an underlying connection between database and LabVIEW through ODBC. Second is using SQL statements to realize specific database operations such as query, insert, delete etc.

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Wang, Jin Liang, Hao Zhang, Meng Ting Zhou, Jia Heng Xu, and Lian Xi Sun. "Electrical Marketing Application System Training's Auxiliary Means that Based on VBA." Applied Mechanics and Materials 667 (October 2014): 7–10. http://dx.doi.org/10.4028/www.scientific.net/amm.667.7.

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In this paper, combined with trainees ' locking mistakenly or doing wrong with work order that others initiated and problems that teaching schedule and teaching quality is unable to control ,we use “Macro Program” and “Microsoft ODBC for Oracle” to develop the training auxiliary tools in the EXCEL' s circumstances by VBA programming technology and then we achieved the goal of the teaching results of closed-loop test and operation of information broadcast which is based on the working process.

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Tang, Jian Gang. "The Research on Embedded Database System of Wireless Network." Applied Mechanics and Materials 511-512 (February 2014): 727–31. http://dx.doi.org/10.4028/www.scientific.net/amm.511-512.727.

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Wireless embedded database system is more complex and flexible than conventional computing environment. Embedded database computing platform requires more technologies such as asymmetric mobility, instability connected topology diversity, network communications, highly scalable systems, low reliability. This paper described the design and development process of embedded database, analyzed the database indexes, data storage and lexical analyzer. It supports CAPI interfaces and standard SQL subset, also supports ODBC or JDBC and bi-directional data exchange, and has a two-way flow of data between the central database and the embedded database.

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Huwei Guan, Yanchun Zhang, and H. H. S. Ip. "Java-based approaches for accessing databases on the Internet and a JDBC-ODBC implementation." Computing & Control Engineering Journal 9, no. 2 (April 1, 1998): 71–78. http://dx.doi.org/10.1049/cce:19980204.

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Su, C., and Z. R. Zhang. "Research on Concurrent Design and GM-Oriented System for Typical Mechanical Products." Key Engineering Materials 426-427 (January 2010): 270–73. http://dx.doi.org/10.4028/www.scientific.net/kem.426-427.270.

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An implementation methodology is proposed to serve a system for the network-based design and GM (Green Manufacturing), and the detailed design process of the system is introduced, which would be universally applicable for mechanical product design for green manufacturing. To realize the remote product data management, the dreamweaver software and FTP functions are used, and some new programs are developed to building the parts library based on UG NX development platform. However, the client database management has been realized by using IIS and ODBC functions. Eventually a prototype system is developed to accomplish concurrent design for green manufacturing.

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Zhang, Ying, and Xin Shi. "Development of AutoCAD Graphic Database Management System Based on Component Technology." Advanced Materials Research 998-999 (July 2014): 1394–97. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.1394.

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In order to query and manage the graphic files efficiently, and improve the graphic management system in the enterprises, based on the research of dwg、dxf formats, using VC++6.0 language, the graphic title bar information database was created in the Access. With the ODBC interface connected to the graphic database, the preview and query of the graphic database were realized with ActiveX technology. By designing and programming good interactive interface, graphics could be modified and translated conveniently as well as updating the database etc. Simultaneously, by setting identification, the security management of the graphic database was realized. Ultimately, the delivery of enterprises was highly improved.

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Cao, Shu Kun, Chang Lei Wang, Hui Zhang, Jie Lv, and Chang Zhong Wu. "Development of Embedded Linux CNC System Based on ARM9." Key Engineering Materials 467-469 (February 2011): 906–11. http://dx.doi.org/10.4028/www.scientific.net/kem.467-469.906.

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Five-axis machining area of free surface is proposed by based on ARM9 and Linux open CNC system's overall structure of the CNC system hardware and software architecture. The system adopts the mode of the host computer PC, the lower computer ARM9 development board. PC completes the model of space surface and generates tool path by Simultaneous Multi-objective Optimization Algorithm on Free-form Surface Five-Axis Machining Tool Path and Tool Posture. The lower computer applies MYSQL database to storage and manage cutter location point information. Other modules access the database through ODBC standard interface. ARM9and PC utilize the way of cross-platform socket data transmission, the stepper motors is controlled by the way of constant acceleration - deceleration.

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Gao, Guo Dong, Wen Xiao Zhang, Gong Zhi Yu, and Jiang Hua Sui. "Research on Crew Examination System Based on Web." Advanced Materials Research 396-398 (November 2011): 2346–48. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.2346.

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With the rapid development of computer technology and Internet, all kinds of distant educations based on Internet have been coming out constantly. To reduce the cost of exam and alleviate the burden of teachers, the crew examination system was designed and implemented. This system is an online examination system which integrates computer network technology, database technology and ASP technology. The B/S model was adopted in this system and using ASP visit ODBC accesses database. This system includes two functions: examination system and management system. Test library management, random questions, online testing, automatic scoring, scores query and other functions were achieved. Crew examination system realizes the change from traditional test’s way to the way based on Internet.

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Sireteanu, Alexandru Napoleon. "A Survey of Web Ontology Languages and Semantic Web Services." Annals of the Alexandru Ioan Cuza University - Economics 60, no. 1 (July 1, 2013): 42–53. http://dx.doi.org/10.2478/aicue-2013-0005.

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Abstract In the beginning World Wide Web was syntactic and the content itself was only readable by humans. The modern web combines existing web technologies with knowledge representation formalisms. In this sense, the Semantic Web proposes the mark-up of content on the web using formal ontology that structure essential data for the purpose of comprehensive machine understanding. On the syntactical level, standardization is an important topic. Many standards which can be used to integrate different information sources have evolved. Beside the classical database interfaces like ODBC, web-oriented standard languages like HTML, XML, RDF and OWL increase in importance. As the World Wide Web offers the greatest potential for sharing information, we will base our paper on these evolving standards.

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Lv, Sai Dong, and Yao Wen Xia. "The Research of Heterogeneous Database Migration Based on XML and Middleware." Applied Mechanics and Materials 556-562 (May 2014): 3350–53. http://dx.doi.org/10.4028/www.scientific.net/amm.556-562.3350.

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For many government departments or enterprises to use new system upgrades, data transfer between heterogeneous database problem, this paper puts forward a kind of heterogeneous database based on XML and middleware model of data migration.The model by using XML technology to build a middleware, through the ODBC interface connected to the source database and target database.After extracting data from the source database into a unified XML documents, again according to the mapping relationship between old and new database and XSL document, and converts it to meet the needs of the target XML document, the target database and load the data to the target database.The model including data extraction, transformation, validation, write, and other functions, is a cross-platform, easy extensibility and reusability.

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Flores Castro, Edwin Geovanny. "Implementación de una base de datos heterogénea distribuida entre los SGBDs ORACLE, MySQL y PostgreSQL con replicación, mediante un script bash implementado en el sistema operativo CentOS usando software libre." INNOVA Research Journal 3, no. 2.1 (February 28, 2018): 68–77. http://dx.doi.org/10.33890/innova.v3.n2.1.2018.668.

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El presente artículo permite obtener una base de datos distribuida heterogénea conreplicación en un ambiente CentOS en menos de 5 minutos, mediante un script bash, usandoúnicamente software libre. La idea se centra en tener un esclavo que será ORACLE y los nodosmaestros estarán en MySQL y PostgreSQL, con la finalidad de reducir costos a la hora dediseñar e implementar una base de datos distribuida ya que se aprovecha al máximo la potenciade un gestor de pago, el cual es Oracle, con la gratuidad y buen desempeño de MySQL yPostgreSQL. El resultado de este artículo será un ODBC que configure los dos gestores singastar un solo centavo y en tiempo récord, y así poder obtener una base de datos distribuidaconformada por distintos gestores, que trabajen como uno solo.

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Ye, Qiong Wei, Guang Xing Song, Yu Hui Feng, and Qiu Yun Nie. "A Research of Principle and Application of Communication Interface between MBMS and DBMS in DDS." Key Engineering Materials 474-476 (April 2011): 478–83. http://dx.doi.org/10.4028/www.scientific.net/kem.474-476.478.

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The communication interface technology of Model Base Management System (MBMS) and Database Management System (DBMS) is one of the key technologies for successful implementation of Decision Support System (DSS). This paper firstly introduces the concept model of communication interface between MBMS and BMS in DDS. Then it makes an analysis of the principle of communication interface between MBMS and BMS in DDS. Based on the analysis, three ways of its implementation are proposed: Standard Format Method, Function Method and Embedding Method, which finally realize the ODBC-based application of communication between MBMS and DBMS in DSS. This paper is of great reference significance for solving communication problems among database, model base, data warehouse, knowledge base, expert base and method base, and for accessing heterogeneous data or even extreme data in such emerging Decision Support Systems as Distributed DSS, Group DSS and Intelligent DSS.

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Zhang, Ming Hu, Shi Jun Lv, De Hu Wang, En Zhong Quan, and Hong Liu. "Fault Grey Diagnostic System Based on Virtual Instrument." Advanced Materials Research 108-111 (May 2010): 1521–26. http://dx.doi.org/10.4028/www.scientific.net/amr.108-111.1521.

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Take example for the fault diagnostic system for shipboard chemical defense equipment, it is developed, applied virtual instrument technology, grey system theory, and database, in order to update entirely the means of the equipment testing. The modularization and universalization are proposed in its database-based design concept, realizing the design of software and hardware. The ODBC technique is applied for the interconnection of databases to ensure the generality and flexibility of the system. The system mode the best of virtual instrument platform and grey diagnosis method, broke through conventional check diagnosis patterns for warships chemical defense equipment, solved the problems of state prediction and trouble-mode recognition of warships chemical defense equipment. It has been proved by experiments that the system has merits both high accuracy and economical practicability. Also it can reduce the application development cycle and cost.

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Zhou, Geng Lie, Chi Bing Hu, Ya Zhou Wang, and Juan Wen Xie. "Application and Integration of Control Network and Information Network." Advanced Materials Research 875-877 (February 2014): 2275–79. http://dx.doi.org/10.4028/www.scientific.net/amr.875-877.2275.

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Enterprise integrated automation is the general trend of industrial control development. The combination of control network and information network provides comprehensive information services for enterprise as production information, production control, planning decisions and sales management as well. The industrial control network and information network integration can realize the information and resources sharing among the enterprises networks and further improve the enterprises informationization and integrated automation level so as to achieve the situation that the enterprise production and management is more efficient and more flexible. The study introduces the information integration of the fieldbus control network and the information network and analyze the information integration technologies such as internetworking, dynamic data exchange (DDE), Open Database Connectivity (ODBC), OLE for Process Control (OPC), control network and information network with unified protocol standards. the integration application of bus system is illustrated with the example of Controller Area Network (CAN) bus.

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Shahsavar, N., H. Åhlfeldt, O. Wigertz, and B. Johansson. "Database and Knowledge Base Integration – A Data Mapping Method for Arden Syntax Knowledge Modules." Methods of Information in Medicine 35, no. 04/05 (September 1996): 302–8. http://dx.doi.org/10.1055/s-0038-1634677.

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Abstract:One of the most important categories of decision-support systems in medicine are data driven systems where the inference engine is linked to a database. It is, therefore, important to find methods that facilitate the implementation of database queries referred to in the knowledge modules. A method is described for linking clinical databases to a knowledge base with Arden Syntax modules. The method is based on a query meta-database including templates for SQL queries which is maintained by a database administrator. During knowledge module authoring the medical expert refers only to a code in the query meta-database; no knowledge is needed about the database model or the naming of attributes and relations. The method uses standard tools, such as C++ and ODBC, which makes it possible to implement the method at many platforms and to link to different clinical databases in a standardized way.

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Hidayat, Wahyu, Muhammad Dwi Aldhi, and Dahliar Ananda. "Teknik Migrasi Data Lintas DBMS dengan Menggunakan Metadata." JURNAL INFOTEL - Informatika Telekomunikasi Elektronika 7, no. 2 (November 10, 2015): 137. http://dx.doi.org/10.20895/infotel.v7i2.41.

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Proses migrasi data biasanya dibutuhkan saat adanya perubahan sistem, format, atau tipe storage. Saat ini telah dikenal beberapa teknik dan kakas untuk melakukan migrasi data, misalnya CSV file, ODBC, SQLDump dan sebagainya. Sayangnya tidak semua teknik tersebut dapat diimplementasikan untuk migrasi data antara dua DBMS yang berbeda. Dalam penelitian ini dipaparkan sebuah teknik migrasi data yang dapat digunakan untuk migrasi data lintas DBMS. Teknik migrasi data yang dipaparkan memanfaatkan metadata yang ada di masing-masing DBMS. Proses migrasi data yang dipaparkan di sini melalui tiga tahap yaitu capture, convert dan construct. Sebuah prototype dibangun untuk menguji teknik migrasi data ini. Dengan menggunakan schema HR dilakukan uji coba migrasi data lintas DBMS antara Oracle dan MySQL. Dengan menggunakan teknik ini, migrasi data full-schema membutuhkan waktu rata-rata 20,43 detik dari DBMS Oracle ke MySQL dan 12,96 detik untuk skenario sebaliknya. Adapun untuk migrasi data parsial dibutuhkan waktu rata-rata 5,95 detik dari DBMS Oracle ke MySQL dan 2,19 detik untuk skenario sebaliknya.

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Miller, Roger, and Gunnar Thorvaldsen. "Beyond Record Linkage: Longitudinal Analysis of Turn-of-the-century Interurban Swedish Migrants." History and Computing 9, no. 1-3 (October 1997): 106–21. http://dx.doi.org/10.3366/hac.1997.9.1-3.106.

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Much attention among computer-using historians has been focused on the intricacies of record linkage, with the aim of constructing life histories for selected population groups. Partly because efforts have been concentrated on linkage procedures, less work has been done on the development of methods for analyzing the resulting longitudinal data sets. This article presents methodological aspects of our work with a migration study based on longitudinal records from two Swedish historical databases. The quality and organization of the databases make record linkage much easier than is true of most cross-sectional population censuses. Thus, after briefly presenting record linkage procedures, we have chosen to focus instead on the issues raised by the ensuing analysis of the datasets. Of special interest from a computer user's standpoint, is the employment of the Open Data Base Connection (ODBC interface, allowing the statistical programs to read data directly from a relational data base. Also of interest, especially from an historian's perspective, is the set of procedures developed to analyze different types of life-course events.

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Moon, Yong K., Yu H. Song, Jae H. Kim, Sang Sik Lee, and Joung H. Mun. "The Development Telemedicine System for Blood Pressure Monitoring via Ethernet." Key Engineering Materials 321-323 (October 2006): 1103–6. http://dx.doi.org/10.4028/www.scientific.net/kem.321-323.1103.

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The objective of this study was to develop an Ethernet-based telemedical blood pressure monitor. Although telemedical applications utilizing a variety of media are currently available, present systems do not provide remote signals with regard to integrated vital information, including blood pressure and pulse rate. In addition, the existing systems are largely embedded-structure, single-access, single-process models. Thus, we developed an Ethernet-based blood pressure monitor which includes a client/server structure, and is a real-time multi-access and multi-process system. The client for the developed system uses the Microsoft Comm Control in Microsoft Visual Basic and ODBC to connect Microsoft Chart Control with DB for a user interface. The server is programmed with the J2SE development platform, in a multi-thread structure. The system is capable of receiving data simultaneously. A TCP/IP socket was used for the Ethernet connection. The JDBC was applied to connect with the database for the saving, searching, and sampling of the data. The data transfer failure rate of the developed system was determined to be less than 0.05%.

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Takiguchi, Soichi, Yutaka Takata, Nobuhiko Takahashi, Kazuhiro Kataoka, Tsukasa Hirashima, Kazuya Kawano, Kyoko Miyasaka, Akihiro Funakoshi, and Akira Kono. "A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene." American Journal of Physiology-Endocrinology and Metabolism 274, no. 2 (February 1, 1998): E265—E270. http://dx.doi.org/10.1152/ajpendo.1998.274.2.e265.

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Otsuka Long-Evans Tokushima fatty (OLETF) rats develop hyperglycemia, hyperinsulinemia, and mild obesity, which are characteristic of human non-insulin-dependent diabetes mellitus. We have shown that two recessive genes, ODB1 mapped on the X chromosome and ODB2 mapped on chromosome 14, are involved in the induction of the diabetes in OLETF rats. Recently we found that OLETF rats are the naturally occurring cholecystokinin type A receptor (CCKAR) gene knockout rats. In this study, we focused on the genotype of CCKAR gene and the ODB1 gene in regulation of glucose homeostasis in the F2 cross of the OLETF rats. Relatively high plasma glucose levels were observed in the F2 offspring with the homozygously disrupted CCKAR gene. A synergistic effect for increasing plasma glucose levels in F2 rats between disrupted CCKAR gene and the ODB1 gene was shown. The CCKAR gene was found to map very close to ODB2 by a linkage analysis using microsatellite markers. These results suggest that CCKAR gene maintains normoglycemia in rats.

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Fan, Pan Guo, Qin Zhong, and Si Yu Chen. "Design of Networked Dual-Core Parallel Processing Data Acquisition System." Advanced Materials Research 433-440 (January 2012): 5672–79. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.5672.

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Whether the test of free-flight stall/spin can be carried out successfully, it depends on the airborne anti-stall parachute system, the performance indexes of the system are related to the test pilots’ safety directly. There are large numbers of test signals in the system and half of them are transient pulse signals, so it requires high real-time capability and data throughput level. Thus the danger of the Ignition testing experiment, Telemetry Tracking Monitoring is requisite. To satisfy the need of measuring electric parameters of an airborne anti-stall parachute system, a multi-thread real-time DAQ system of multi-task is constructed, using dual-core industrial computer and high-speed DAQ card as its core, LabWindows/CVI as VI software platform. By a method of dual-core parallel processing through OS kernel, system accomplishes multi-channel data acquisition with high real-timing and huge data throughput, and through TCP/IP, ODBC interface, remote measurement and database management is also accomplished. At the last, the system design a modularize software by DLL technology, packaging several functional modules in DLL form. This system implements the multi-thread mechanism and its synchronization, TCP/IP communication and parallel processing under LabWindows/CVI platform. Finally high real-timing and reliability of this system are validated by experiment.

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Aaljoki, Kari. "Automated Quality Assurance of Online NIR Analysers." Journal of Automated Methods and Management in Chemistry 2005, no. 2 (2005): 44–49. http://dx.doi.org/10.1155/jammc.2005.44.

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Modern NIR analysers produce valuable data for closed-loop process control and optimisation practically in real time. Thus it is highly important to keep them in the best possible shape. Quality assurance (QA) of NIR analysers is an interesting and complex issue because it is not only the instrument and sample handling that has to be monitored. At the same time, validity of prediction models has to be assured. A system for fully automated QA of NIR analysers is described. The system takes care of collecting and organising spectra from various instruments, relevant laboratory, and process management system (PMS) data. Validation of spectra is based on simple diagnostics values derived from the spectra. Predictions are validated against laboratory (LIMS) or other online analyser results (collected from PMS). The system features automated alarming, reporting, trending, and charting functions for major key variables for easy visual inspection. Various textual and graphical reports are sent to maintenance people through email. The software was written with Borland Delphi 7 Enterprise. Oracle and PMS ODBC interfaces were used for accessing LIMS and PMS data using appropriate SQL queries. It will be shown that it is possible to take actions even before the quality of predictions is seriously affected, thus maximising the overall uptime of the instrument.

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Parassa, Yonatan. "AUTOREPORT SISTEM INFORMASI DOKUMEN EVALUASI DIRI PROGRAM STUDI PADA PERGURUAN TINGGI." JURNAL ILMIAH SAINS 11, no. 1 (April 1, 2011): 77. http://dx.doi.org/10.35799/jis.11.1.2011.47.

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Penelitian ini bertujuan membangun sistem informasi dokumen evaluasi diri yang mampu menyajikan data/informasi mengenai dokumen evaluasi diri program studi pada perguruan tinggi secara cepat dan akurat. Metode yang digunakan untuk membangun Sistem informasi dokumentasi evaluasi diri perguruan tinggi adalah metode air terjun. Perangkat lunak yang digunakan untuk membangun sistem ini adalah bahasa pemograman Borland Delphi 7.0. Hasil peneltian menunjukkan bahwa Autoreport sistem Informasi penyusunan dokumen evaluasi diri perguruan tinggi yang dibangun dapat menghasilkan dokumen evaluasi diri program studi yang lebih cepat dari sistem yang digunakan selama. Dengan sistem ini dapat memberikan kemudahan bagi pengelola program studi dalam mengambil keputusan. AUTOREPORT INFORMATION SYSTEM OF SELF-EVALUATION DOCUMENTS OF STUDY PROGRAM IN HIGHER EDUCATIONABSTRACTThe objective of the research was to develop information system of self-evaluation documents of higher education which could present the information concerning self-evalution documents of study program in the higher education quickly and accurately. The method used to develop information System of Self-Evaluation Documents of Higher Education was a water fall method. The sofware used to develop the was the programming language of Borland Delphi 7.0, MySQL Server, ODBC-5.1.6, and Crystal Report 7.0. The result of the research revelas that Autoreport of the information System of Self-Evaluation Documents of Higher Education develop can produce the self-evaluation documents of the the study program faster than the system used, so that it gives easiness for the study program management in making decision.

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Azevedo, Jose Manuel, Ema P. Oliveira, and Patrícia Damas Beites. "Using Learning Analytics to evaluate the quality of multiple-choice questions." International Journal of Information and Learning Technology 36, no. 4 (August 5, 2019): 322–41. http://dx.doi.org/10.1108/ijilt-02-2019-0023.

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Purpose The purpose of this paper is to find appropriate forms of analysis of multiple-choice questions (MCQ) to obtain an assessment method, as fair as possible, for the students. The authors intend to ascertain if it is possible to control the quality of the MCQ contained in a bank of questions, implemented in Moodle, presenting some evidence with Item Response Theory (IRT) and Classical Test Theory (CTT). The used techniques can be considered a type of Descriptive Learning Analytics since they allow the measurement, collection, analysis and reporting of data generated from students’ assessment. Design/methodology/approach A representative data set of students’ grades from tests, randomly generated with a bank of questions implemented in Moodle, was used for analysis. The data were extracted from a Moodle database using MySQL with an ODBC connector, and collected in MS ExcelTM worksheets, and appropriate macros programmed with VBA were used. The analysis with the CTT was done through appropriate MS ExcelTM formulas, and the analysis with the IRT was approached with an MS ExcelTM add-in. Findings The Difficulty and Discrimination Indexes were calculated for all the questions having enough answers. It was found that the majority of the questions presented values for these indexes, which leads to a conclusion that they have quality. The analysis also showed that the bank of questions presents some internal consistency and, consequently, some reliability. Groups of questions with similar features were obtained, which is very important for the teacher to develop tests as fair as possible. Originality/value The main contribution and originality that can be found in this research is the definition of groups of questions with similar features, regarding their difficulty and discrimination properties. These groups allow the identification of difficulty levels in the questions on the bank of questions, thus allowing teachers to build tests, randomly generated with Moodle, that include questions with several difficulty levels in the tests, as it should be done. As far as the authors’ knowledge, there are no similar results in the literature.

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Hirashima, T., K. Kawano, S. Mori, and T. Natori. "A Diabetogenic Gene, ODB2, Identified on Chromosome 14 of the OLETF Rat and Its Synergistic Action with ODB1." Biochemical and Biophysical Research Communications 224, no. 2 (July 1996): 420–25. http://dx.doi.org/10.1006/bbrc.1996.1042.

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Sanni*, Rachana R., and H. S. Guruprasad. "Hospital Management using OAM [Operation Administration & Maintenance] Tool." International Journal of Innovative Technology and Exploring Engineering 10, no. 10 (August 30, 2021): 24–30. http://dx.doi.org/10.35940/ijitee.j9391.08101021.

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This paper proposes a software tool to monitor the system configuration for Hospital Management System. The OAM tool monitors the system configurations after the user installs it into the system. The aim of this software is to monitor the system about its configurations and install the required softwares to the respective system. There are four tools in this application, Fintal, Piston, Naavi and Mapel. To install these, a technique of single file installation using batch scripting is used. Batch scripting is used to execute the installation files of softwares and the softwares are installed. These installation files of softwares will be embedded as execution commands in a single file called “windows batch file”, which should be saved with the extension as “.bat”. The installation that starts will be displayed in the command prompt to know whether the softwares are getting installed correctly. After each installation, the configuration and initialization of installed softwares will be displayed. The required softwares are to be installed. Each of these performs particular tasks that are required for the management of Hospitals. Fintal is used for overall management of Hospital. This is the most user-friendly part of OAM Tool. This handles overall administrative part of Hospitals. Piston is used for storing patient’s details. This stores the patients’ reports in detailed manner of each test the patient has undergone. Naavi is used for storing Laboratory details. The tests of each patient are stored here. And the last one, i.e., Mapel which is used for storing pharmaceuticals details (Medicines). It stores the details of medicines such as from which pharmaceuticals the medicines are purchased. The license of the hospital is also stored in this part of OAM Tool. All these together form an OAM Tool. This tool also manages other required softwares like, MySQL, ODBC drivers, etc. The management of Hospitals is very important as there is a need to maintain the patient details. This technique of installation is proposed in this paper to make the installation from hardware to remote installation such as, giving the access to the system in which the tool needs to be installed and to save the time of installation process.

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Fromer, Margot J. "ODAC Discussion." Oncology Times 30, no. 7 (April 2008): 23–26. http://dx.doi.org/10.1097/01.cot.0000317229.01702.2f.

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Grillo-López, Antonio J. "The ODAC chronicles: Part 1. My first ODAC experience." Expert Review of Anticancer Therapy 4, no. 5 (October 2004): 709–12. http://dx.doi.org/10.1586/14737140.4.5.709.

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Fromer, Margot J. "Being ODAC Chair." Oncology Times 24, no. 5 (May 2002): 1. http://dx.doi.org/10.1097/01.cot.0000285921.04692.77.

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Chandrasekaran, N., and Geert Ensing. "ODC." Communications of the ACM 47, no. 5 (May 1, 2004): 47. http://dx.doi.org/10.1145/986213.986237.

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Papakonstantinou, Elli. "ODC." Journal of Greek Media & Culture 3, no. 2 (October 1, 2017): 241–43. http://dx.doi.org/10.1386/jgmc.3.2.241_1.

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Hirashima, Tsukasa, Kazuya Kawano, Shigehito Mori, Zhi-Wei Man, and Takashi Natori. "A new diabetogenic gene, ODB2, assigned on chromosome 14 of the OLETF rat developing diabetic syndrome of NIDDM type and its synergistic action with ODB1." Experimental and Clinical Endocrinology & Diabetes 105, S 03 (July 15, 2009): 40. http://dx.doi.org/10.1055/s-0029-1211856.

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Kunwar, Saket. "SEGMENTATION AND CLASSIFICATION OF NEPAL EARTHQUAKE INDUCED LANDSLIDES USING SENTINEL-1 PRODUCT." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B7 (June 21, 2016): 769–74. http://dx.doi.org/10.5194/isprsarchives-xli-b7-769-2016.

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On April 26, 2015, an earthquake of magnitude 7.8 on the Richter scale occurred, with epicentre at Barpak (28°12'20''N,84°44'19''E), Nepal. Landslides induced due to the earthquake and its aftershock added to the natural disaster claiming more than 9000 lives. Landslides represented as lines that extend from the head scarp to the toe of the deposit were mapped by the staff of the British Geological Survey and is available freely under Open Data Commons Open Database License(ODC-ODbL) license at the Humanitarian Data Exchange Program. This collection of 5578 landslides is used as preliminary ground truth in this study with the aim of producing polygonal delineation of the landslides from the polylines via object oriented segmentation. Texture measures from Sentinel-1a Ground Range Detected (GRD) Amplitude data and eigenvalue-decomposed Single Look Complex (SLC) polarimetry product are stacked for this purpose. This has also enabled the investigation of landslide properties in the H-Alpha plane, while developing a classification mechanism for identifying the occurrence of landslides.

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Kunwar, Saket. "SEGMENTATION AND CLASSIFICATION OF NEPAL EARTHQUAKE INDUCED LANDSLIDES USING SENTINEL-1 PRODUCT." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B7 (June 21, 2016): 769–74. http://dx.doi.org/10.5194/isprs-archives-xli-b7-769-2016.

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On April 26, 2015, an earthquake of magnitude 7.8 on the Richter scale occurred, with epicentre at Barpak (28°12'20''N,84°44'19''E), Nepal. Landslides induced due to the earthquake and its aftershock added to the natural disaster claiming more than 9000 lives. Landslides represented as lines that extend from the head scarp to the toe of the deposit were mapped by the staff of the British Geological Survey and is available freely under Open Data Commons Open Database License(ODC-ODbL) license at the Humanitarian Data Exchange Program. This collection of 5578 landslides is used as preliminary ground truth in this study with the aim of producing polygonal delineation of the landslides from the polylines via object oriented segmentation. Texture measures from Sentinel-1a Ground Range Detected (GRD) Amplitude data and eigenvalue-decomposed Single Look Complex (SLC) polarimetry product are stacked for this purpose. This has also enabled the investigation of landslide properties in the H-Alpha plane, while developing a classification mechanism for identifying the occurrence of landslides.

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Versteeg, Gregory, and Kanu Goyal. "Radiologist Identification of Occult Dorsal Wrist Ganglion Cysts on MRI." Journal of Wrist Surgery 08, no. 04 (March 25, 2019): 276–79. http://dx.doi.org/10.1055/s-0039-1683847.

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Background Occult dorsal ganglion cysts (ODGC) require imaging or an operation for detection. It is currently unknown how often a radiologist identifies an ODGC on magnetic resonance imaging (MRI) and whether surgeon indication for MRI aids the radiologist in detection. Questions/Purposes The aim of the study was to investigate the following questions: how accurately do radiologists identify ODGC on MRIs? What factors may be associated with missed ODGCs? Patients and Methods We retrospectively studied patients who underwent an operation for an ODGC and had a preoperative wrist MRI. Radiology report and surgeon's notes were evaluated to determine whether identification of the ODGC was noted and whether the surgeon indicated that the MRI was to evaluate for an ODGC. MRIs were reviewed, dimensions of cysts measured and volume of cyst calculated. Results Twenty-four patients and 25 MRIs were analyzed. The radiologist identified the ODGC in 19 cases (76%). Fifteen of the 25 MRIs (60%) ordered had ODGC listed in the requisition comment by the ordering surgeon. Thirteen of these 15 (87%) ODGCs were seen by the radiologist. Ten of the 25 MRIs (40%) ordered did not mention ODGC in the requisition. Six of these 10 (60%) ODGCs were seen by the radiologist. The volume of the ODGCs missed by radiologists was smaller (mean, 0.049 cm3) than those the radiologists identified (mean, 0.31 cm3; p = 0.004). Conclusions Radiologists will not always identify the ODGC on an MRI, but they were more likely to if the surgeon was concerned for one. Hand surgeons should report suspicion of an ODGC on MRI requisition and review all imaging independently. Level of Evidence This is a Level III, prognostic study.

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Bocanegra, Jenny Paola, Dionisio Humberto Malagón, and Luisa Fernanda López. "Obtención de biodiesel a partir de aceite usado de cocina por trans-esterificación." Ingenieria y Universidad 19, no. 1 (April 4, 2015): 155. http://dx.doi.org/10.11144/javeriana.iyu19-1.odba.

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<p>La evaluación de diferentes aceites vegetales para la obtención de biocombustibles se ha convertido en una estrategia global en la producción de biodiesel, con miras a la reducción de costos de producción, aumentar el rendimiento de la reacción, evitar el uso de materias primas consideradas como alimentos y disminuir la contaminación ambiental. En el presente trabajo se evaluó la obtención de biodiesel a partir de aceite usado de cocina, por medio de catálisis con hidróxido de sodio y potasio. Se evaluaron tres relaciones molares de metanol:aceite, 6:1, 9:1 y 12:1, dos catalizadores KOH y NaOH y dos porcentajes de catalizador 1% y 2%; se realizó un diseño factorial por duplicado. La temperatura se mantuvo en 60°C y el tiempo de reacción en 2 horas. Se determinó el contenido de metil ésteres, mono, di y triglicéridos mediante cromatografía de gases. Las mejores condiciones para NaOH y KOH como catalizadores se obtuvieron cuando el porcentaje de catalizador fue 1% y la relación molar alcohol:aceite fue 12:1. En estas condiciones se obtuvo una conversión del 64,1 %, un rendimiento de 98 % y un porcentaje de metil ésteres de 99,1% cuando el catalizador fue NaOH; con KOH la conversión fue 63,2%, el rendimiento fue 88% y el porcentaje de metil-ésteres fue 98,4%. Los resultados de este estudio muestran un alto rendimiento de la reacción usando aceite usado, por lo cual su implementación a nivel industrial dependerá de la evaluación económica.</p><p> </p>

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Betancourt Vélez, Ricardo. "¿El ocaso de la Doctrina Monroe? Colombia y Brasil, entre el norte de siempre y un sur renovado." Papel Político 19, no. 2 (July 1, 2015): 691. http://dx.doi.org/10.11144/javeriana.papo19-2.odmc.

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En los siglos XIX y XX, Estados Unidos definió a Latinoamérica como su ‘patio trasero’ a partirde la formulación de la Doctrina Monroe. Sin embargo, las transformaciones globales y regionales que se vienen desarrollando en el siglo XXI han debilitado dicha doctrina y han posibilitado la aparición de una nueva concepciónde espacio, llamado Suramérica, como una interesante alternativa. En este artículo se analiza el papel de Brasil como potencia regionalque lidera la construcción de este nuevo espacio.Asimismo analiza el papel de Colombia,tradicional aliado de Estados Unidos, ante la aparición del liderazgo brasileño.

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Golembiewski, Robert T. "ODC SYMPOSIUM II." International Journal of Organizational Analysis 4, no. 2 (February 1996): 117–22. http://dx.doi.org/10.1108/eb028843.

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dos Santos, Guilherme A., Carolina H. Thomé, Germano Aguiar Ferreira, Priscila S. Scheucher, Antonio R. Lucena-Araujo, Kleber T. de Oliveira, Hamilton L. Gimenes-Teixeira, et al. "Linker of Activation of T Cells – 2 (LAT2), a Lipid Raft-Associated Adaptor Protein, Is a Novel Target for Therapy in Acute Leukemia." Blood 118, no. 21 (November 18, 2011): 737. http://dx.doi.org/10.1182/blood.v118.21.737.737.

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Abstract Abstract 737 Lipid rafts are highly ordered membrane domains that are enriched in cholesterol and sphingolipids and function in providing a scaffold to signal transduction. Altered raft assembly has been implicated in breast and colorectal cancer progression; rafts are essential to sustained p38K activation by GM-CSF and VEGFa in acute myeloid leukemia (Saulle et al. BJH, 2009). In a previous study, we showed that 10-(Octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets raft like domains in model membranes and induces apoptosis in leukemia cells, (ED-50 25mM - NB4), but spares normal hematopoietic and epithelial cells (dos Santos et al. BBACTA 2010). Here, we performed an unbiased quantitative proteomic screen of ODPC targets in lipid rafts. We used stable isotope labeling in cell culture (SILAC) to reveal proteins that are modulated by ODPC before the installation of apoptosis, to gain access to the primary mechanisms of drug action (Fig 1A, B and C). We used successive detergent extraction (Fig 1D) to isolate detergent resistant membranes (DRM) enriched in lipid rafts; blots with specific markers prove the quality of fractionation (Fig 1E). Proteins were considered modulated if: fold change of 2/0.5 or greater plus two or more quantification events and a P value <0.1. A small fraction of proteins was modulated by ODPC (Fig 1F). Of the 1426 proteins identified in the total extract, only one protein (0.07%) was upregulated. Of the 1314 proteins identified in the DRM, 6 proteins (0.45%) were donwregulated. Of these, 4 have predicted or validated palmitoylation sites (Fig 1F). We validated that ODPC downregulates LAT-2 (Fig 2A), an adaptor protein that is target to rafts by palmitoylation and is expressed in B cells and myeloid cells. Interesting, LAT-2 was not expressed in K562 (Fig 2A), a cell resistant to ODPC-induced apoptosis (Fig 1A and B). Moreover, ODPC induced a loss of LAT-2 in the lipid rafts of NB4 cells after 3h of treatment (Fig 2B). Since LAT-2 may function as an adaptor protein in AKT signalization (Roget et al. J.Immunol. 2008) we evaluate the effect of ODPC on the ATK pathway. Fig 2C shows that ODPC induces a downregulation of all components from AKT signaling, compatible with a membrane target drug. However, in functional experiments, ODPC inhibited AKT activation in NB4 cells by myeloid growth factors (MGF), after few minutes of incubation, in a similar way of the specific PI3K inhibitor Wortmannin (Fig 2D). Moreover, in these experiments, MGF induced a rapid and translation-dependent up regulation in LAT-2 expression in control treated cells (Fig 2E). This effect was partially suppressed by ODPC treatment and was suppressed by Wortmannin (Fig 2D). This suggests that LAT-2 translation is highly regulated and dependent on a functional AKT pathway. Indeed, phosphorylation of 4EBP-1 and ribossomal S6 kinase (S6K) with consequent upregulation of translation in the ribosome is downstream of PI3K/AKT/mTOR (Mamane et al. Oncogene, 2006). Moreover, we confirmed a hypophosphorilation state of S6K in the presence of ODPC or Wortmannin (Fig 2D). Interesting, we have identified two potential-palmitoylated ribosomal proteins (RP) to be downregulated in the lipid raft fraction of ODPC treated cells (Fig 1F). This finding confirms previous reports that a raft disruption treatment (methyl-β-cyclodextrin) causes downregulation of several RP (Foster, De Hoog and Mann. PNAS, 2003) and that palmitoylation target ribosome proteins to lipid rafts (Wei et al. MCP, 2010). This indicates that ODPC may present also a direct or indirect inhibitory effect on translational apparatus. Our results strongly indicate that ODPC acts on LAT-2 by interference with its protein-lipid interactions, since experimental-induced disturbances in lipid raft physiology recapitulate or increase ODPC effects on LAT-2 expression (Fig 3A and B). To further clarify the mechanism of LAT-2 downregulation we evaluate if it is degraded by the proteasome after ODPC or 2BrPA treatments. Fig 3C and D reveals that this is the case. This confirms the findings of Orr and McVicar (J.Leuk.Biol. 2011) of ubiquitin-proteasomal regulation of LAT-2 stability. Taken together, our results demonstrate that a lipid raft targeting drug may present several effects on signal transduction, causing a severe toxicity to leukemia cells. Moreover, adaptor proteins like LAT-2 emerge as possible new therapeutic targets in leukemia. Disclosures: No relevant conflicts of interest to declare.

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Misiak, Paweł. "Dynamical susceptibility in description of ODIC." Molecular Physics 58, no. 5 (August 10, 1986): 947–57. http://dx.doi.org/10.1080/00268978600101691.

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Edgecombe, Rodney Stenning. "Odic Elements in Charlotte Bronte's "Villette"." Modern Language Review 87, no. 4 (October 1992): 817. http://dx.doi.org/10.2307/3731421.

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Garber, K. "ODAC Panel Gives Nod to Bexxar." JNCI Journal of the National Cancer Institute 95, no. 3 (February 5, 2003): 189. http://dx.doi.org/10.1093/jnci/95.3.189.

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Murakami, Y., K. Fujita, T. Kameji, and S. Hayashi. "Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells." Biochemical Journal 225, no. 3 (February 1, 1985): 689–97. http://dx.doi.org/10.1042/bj2250689.

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A new method was developed for the assay of ornithine decarboxylase (ODC)-antizyme complex, in which alpha-difluoromethylornithine (DFMO)-inactivated ODC was used to release active ODC competitively from the complex. ODC-antizyme complex was present in the extracts of hepatoma tissue-culture (HTC) cells and of ODC-stabilized variant HMOA cells, in much larger amounts in the latter. Cellular amounts of the complex fluctuated after a change of medium in a similar manner in HTC and HMOA cells, increasing during the period of ODC decay. After treatment with cycloheximide, the decay of ODC-antizyme complex in HMOA cells was more rapid than the decay of free ODC, but it was much slower than the decay of free ODC or complexed ODC in HTC cells. Administration of putrescine caused a rapid increase in the amount of ODC-antizyme complex in both HTC and HMOA cells, but nevertheless the decay of total ODC (free ODC plus ODC-antizyme complex) was more rapid with putrescine than with cycloheximide. These results suggested the possibility that ODC is degraded through complex-formation with antizyme. In contrast with complexed antizyme, free antizyme was not stabilized in HMOA cells.

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MURAKAMI, Yasuko, Nobuyuki TANAHASHI, Keiji TANAKA, Satoshi ŌMURA, and Shin-ichi HAYASHI. "Proteasome pathway operates for the degradation of ornithine decarboxylase in intact cells." Biochemical Journal 317, no. 1 (July 1, 1996): 77–80. http://dx.doi.org/10.1042/bj3170077.

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Ornithine decarboxylase (ODC) is degraded in an ATP-dependent manner in vitro by the 26 S proteasome in the presence of antizyme, an ODC destabilizing protein induced by polyamines. In the present study we examined whether the proteasome catalyses ODC degradation in living mammalian cells. Lactacystin, the most selective proteasome inhibitor, strongly inhibited the degradation of ODC that had been induced in hepatoma tissue-culture (HTC) cells by refeeding with fresh medium. Furthermore the inhibitor inhibited the rapid degradation of ODC that had been induced by hypotonic shock. Interestingly, hypertonic shock was found to increase the proportion of ODC present as a complex with antizyme (the ratio of ODC–antizyme complex to total ODC). Cycloheximide, which partly inhibits rapid ODC degradation caused by hypertonic shock, also partly inhibited the increase in the ratio of ODC–antizyme complex to total ODC. These results suggest that a common ODC degradation pathway, namely the antizyme-dependent and 26 S proteasome-catalysed ODC degradation pathway, is also operating in intact cells for osmoregulated ODC degradation.

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Journal articles on the topic 'ODBC'

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