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Journal articles on the topic 'Offending agent'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kam, April J., Alex F. Manini, and Lewis S. Nelson. "First, Remove the Offending Agent." American Journal of Cardiology 102, no. 3 (2008): 370–71. http://dx.doi.org/10.1016/j.amjcard.2008.04.005.

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2

Godlovitch, Stan. "Offending against Nature." Environmental Values 7, no. 2 (1998): 131–50. http://dx.doi.org/10.1177/096327199800700201.

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Some environmental views characterise the human abuse of nature as an offence against nature itself. What conception of nature would best fit that characterisation? To focus upon such a conception, aesthetic offences against nature are examined and distinguished at the outset from moral offences. Aesthetic offences are divided into those internal to our cultural outlook and external to it. The external outlook, conceiving nature as a thing wholly apart from us, is shown to be necessary to any view of nature being offended against. Central to the external outlook is a conception of nature as th

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Keshmiri, Hesam, Anuj Behal, Shawn Shroff, and Charles Berkelhammer. "Clopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review." Case Reports in Hepatology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/8068276.

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Clopidogrel is a commonly prescribed antiplatelet agent that carries a rare risk of hepatotoxicity. We describe a case of severe clopidogrel-induced hepatitis with liver biopsy assessment. Prompt recognition and withdrawal of the offending agent are imperative to prevent progression and potentially fatal liver injury.

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Thompson, Brittany M., Joshua M. Brady, and Jeffrey D. McBride. "Bridging the Gap between Dermatology and Psychiatry: Prevalence and Treatment of Excoriation Disorders Secondary to Neuropsychiatric Medications." Psych 5, no. 3 (2023): 670–78. http://dx.doi.org/10.3390/psych5030043.

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(1) Background: The dermatillomania and trichotillomania disorders in this study refer to the subcategory of obsessive-compulsive disorders (OCDs) that are medication-induced. Patients with typical dermatillomania or trichotillomania disorder generally present with other OCD symptoms, although this is not present in the cases of medication-induced skin picking or hair pulling disorders found in the current literature. This paper serves to investigate the prevalence and treatment methods of medication-induced excoriation disorders. (2) Methods: The PubMed database was queried for cases of medic

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Blyth, Dana, Elizabeth Markelz, and Jason Okulicz. "Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy." Infectious Disease Reports 4, no. 1 (2012): 11. http://dx.doi.org/10.4081/idr.2012.e11.

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Many cases of cutaneous vasculitis are druginduced with histology revealing leukocytoclastic vasculitis (LCV). We present a case of levofloxacin- associated LCV successfully treated with prednisone and cessation of the offending drug. Although case reports describe a link between LCV and older fluoroquinolones, such as ciprofloxacin and ofloxacin, recent reports have implicated the newer fluoroquinolone levofloxacin. Recognition of fluoroquinoloneinduced cutaneous vasculitis is important as continuation or re-exposure of the offending agent may have life-threatening consequences.

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Vucicevic Boras, Vanja, Vlaho Brailo, Ana Andabak Rogulj, Danica Vidovic Juras, Dragana Gabric, and Danko Velimir Vrdoljak. "Oral Adverse Reactions Caused by Over-the-Counter Oral Agents." Case Reports in Dentistry 2015 (March 26, 2015): 1–4. http://dx.doi.org/10.1155/2015/196292.

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Over-the-counter products rarely cause unwanted reactions in the oral cavity. Oral reactions to these agents are not specific and might present with various clinical oral findings. Detailed medical history is a key to the proper diagnosis of these lesions and fortunately other diagnostic procedures are rarely needed. Lesions are usually managed with elimination of the offending agent and with topical steroids. In more severe cases systemic steroids should be applied.

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Dr., Rajkumar Kothiwal, Rakesh Yadav Dr., Deepak S. Bohra Dr., et al. "Trends of steroid modified tinea at tertiary care hospital in India." International Multispeciality Journal of Health 3, no. 7 (2017): 263–67. https://doi.org/10.5281/zenodo.837991.

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<strong><em>Abstract—</em></strong>Dermatophytes are the common fungal agents implicated in superficial skin infections worldwide, commonly known as tinea. They include species of Trichophyton, Microsporum and Epidermophyton. Infections of this organism have dramatically increased in last one decade by misuse of topical corticosteroids cream alone or in combination with topical antibacterial and antifungal agents. So this study was conducted with the aim to study about culprits (prescribers) and various offending agents. This study was conducted on 1239 consecutive patients of tinea between ag

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Dr., Rajkumar Kothiwala, Deepak S. Bohra Dr., Rakesh Kumar Dr., et al. "Alarming tropical steroid misuse on face: A descriptive study." Alarming tropical steroid misuse on face: A descriptive study 3, no. 7 (2017): 210–14. https://doi.org/10.5281/zenodo.837290.

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<strong>Abstract—</strong> Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. The clinical lesions are non-inflammatory open and closed comedones and or papules, pustules and nodules of varying degree of inflammation and depth. A lot of steroid, cosmetic and Ayurvedic products containing unlabeled depigmenting agent and steroids are available readily over the counter sale. The side effects of these products are not documented and can lead to adverse effects of continuous usage. This study was aimed to find out various offending depigmenting agents (topical unlabeled ste

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Arshad, Hafiz, Arsalan Khan, Usama Assad, Muaiad Kittaneh, and Charles Berkelhammer. "Antihistamine-Induced Hepatitis: 2 Cases Involving Loratidine." Case Reports in Hepatology 2016 (2016): 1–2. http://dx.doi.org/10.1155/2016/6890313.

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Antihistamine-induced hepatitis is rare. We present 2 cases of antihistamine-induced hepatitis with autoimmune features, caused by loratidine. One case was confirmed by rechallenge. Identifying and discontinuing the offending agent are essential for treatment.

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Williams, DR, and RJ Stark. "Intravenous Lignocaine (Lidocaine) Infusion for the Treatment of Chronic Daily Headache with Substantial Medication Overuse." Cephalalgia 23, no. 10 (2003): 963–71. http://dx.doi.org/10.1046/j.1468-2982.2003.00623.x.

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Patients with chronic daily headache with medication overuse are difficult to treat, especially when the doses of analgesia are substantial. We have previously shown that intravenous lignocaine (lidocaine) infusion is useful in maintaining pain control while the offending analgesic agent is withdrawn in these patients. The published data on long-term efficacy of this treatment is limited. We undertook a retrospective survey of 71 consecutive patients admitted for lignocaine infusion (mean 8.7 days) for treatment of chronic daily headache, with substantial analgesic abuse. Ninety percent of pat

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LaDuca, Jeffrey R., Peter H. Bouman, and Anthony A. Gaspari. "Nonsteroidal Antiinflammatory Drug-Induced Pseudoporphyria: A Case Series." Journal of Cutaneous Medicine and Surgery 6, no. 4 (2002): 320–26. http://dx.doi.org/10.1177/120347540200600402.

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Background: Pseudoporphyria is a diagnosis that is used when porphyria-like clinical lesions arise in the setting of normal porphyrin levels. This condition was first described in the 1960s and was initially related to the use of certain antibiotic drugs. In 1985, pseudoporphyria was first attributed to the use of nonsteroidal antiinflammatory drugs (NSAIDs). Subsequently, a host of NSAIDs and other drugs have been found to elicit the same clinical entity. The exact mechanism by which certain drugs create clinical lesions resembling porphyria cutanea tarda or erythropoietic protoporphyria is s

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Hekmatjah, Joshua, Kinza Tareen, and Ruqiya Shama Tareen. "Citalopram-Associated Alopecia: A Case Report and Brief Literature Review." Current Drug Safety 14, no. 2 (2019): 167–70. http://dx.doi.org/10.2174/1574886314666190215115857.

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Background: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer an improved side effect profile compared to older treatments, which improves patients’ adherence and quality of life. Case Report:Here we discuss a case of an uncommon, but a distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. The patient was diagnosed with behavioral variant frontotemporal dementia and was started on citalopram 20 mg and aripiprazole 5 mg daily. At 3.5 months the patient comp

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Samajdar, Shambo Samrat, Jayanta Sharma, Shatavisa Mukherjee, et al. "Clinical Pharmacological Principles in Emergency Geriatric Care: Toxidrome Approach." Journal of the Indian Academy of Geriatrics 19, no. 4 (2023): 282–84. http://dx.doi.org/10.4103/jiag.jiag_21_23.

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Abstract An increasing body of research implies that emergency department (ED) physicians fail to identify drug-related ED visits due to the department’s hectic workflow. In cases of poisoning or drug intoxications, the offending agent(s) may not be identified during the acute and possibly critical period of the exposure. For cases of suicidal incidents, laboratory assistances in identifying the offending chemical are not promptly available. The diagnosis of “toxidromes” is, therefore, an acceptable clinical diagnostic method that has been pioneered by clinical toxicologists. The present case

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Bai, Jina, and Todd Cutler. "Drug-induced aseptic meningitis after amoxicillin use." JAAPA 38, no. 4 (2025): 29–31. https://doi.org/10.1097/01.jaa.0000000000000198.

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ABSTRACT Drug-induced aseptic meningitis (DIAM) is a noninfectious meningitis related to a drug exposure. Diagnosis requires exclusion of infectious meningitis. Patients with DIAM will exhibit rapid improvement after discontinuation of the offending drug. Most patients will develop recurrent symptoms after repeat exposure to the offending agent. The clinical features of DIAM are indistinguishable from infectious meningitis and the recurrent symptoms often are identical to previous episodes of DIAM. Nonsteroidal anti-inflammatory drugs, co-trimoxazole, and penicillin are the medications that mo

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Laughon, Sarah L., Michael Duplisea, Carolyn Ziemer, et al. "760 Patients with Pre-existing Mental Illness Who Developed Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Lessons Learned at a Large Tertiary Burn Center and the Importance of Accurately Diagnosing Psychiatric Disorders." Journal of Burn Care & Research 41, Supplement_1 (2020): S213—S214. http://dx.doi.org/10.1093/jbcr/iraa024.339.

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Abstract Introduction In recent years, burn centers are managing more patients with exfoliative skin disorders including Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS/TEN overlap. While it is well known that burn patients have higher rates of co-morbid psychiatric disorders than the general population, the incidence of pre-existing psychiatric disorders among patients who develop SJS, SJS/TEN overlap, and TEN is unknown. This study aimed to characterize a cohort of patients with pre-existing psychiatric disorders admitted to a tertiary burn center for treatment of S

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Morarasu, Bianca Codrina, Adorata Elena Coman, Cristina Bologa, et al. "Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review." Journal of Personalized Medicine 12, no. 12 (2022): 2069. http://dx.doi.org/10.3390/jpm12122069.

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Serotonin syndrome (SS) is a clinical toxidrome with high variability in clinical practice. It develops due to increased serotonin levels in the central nervous system. With an underestimated frequency, SS can develop following an overdose, a therapeutic dose increase, or drug to drug interaction of at least one serotonergic agent. It can present with autonomic signs, neuromuscular changes and an altered mental status. However, history and clinical examination are key features to formulate the diagnosis. Treatment options consist of supportive measures, discontinuation of the offending agent a

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Girgiss Nicola, Wassef, Mina Wassef Girgiss, Aly Mohamed Ezz El-Arab, Ahmed Ahmed, and Eman Refaat Youness. "Role of Inulin in the Protection and Management of Metabolic Inflammation in Humans." Biomedical and Pharmacology Journal 11, no. 2 (2018): 1083–90. http://dx.doi.org/10.13005/bpj/1469.

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Systemic inflammation describes certain metabolic alterations which are mediated by inflammatory cytokines. Theses occur essentially as a defensive body response towards offending agents such as surplus nutrient staffs. Our aim is to find out the role of inulin as a protective agent against metabolic inflammation. Twenty eight type 2 diabetic females were subjected to the estimation of their serum high sensitivity C-reactive protein, lipopolysaccharides, tumor necrosis factor alpha, adiponectin and HOMA-IR test before and after three weeks of inulin ingestion. There was a significant drop in t

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18

Agabawi, Salem. "Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic." Case Reports in Infectious Diseases 2019 (December 11, 2019): 1–3. http://dx.doi.org/10.1155/2019/4289502.

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Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. Here, I report a case of a 56-year-old male who presented to a health care facility with shock and meningitis-like syndrome in two occasions, one year apart following an exposure to trimethoprim-sulfamethoxazole for treatment of skin/soft tissue infection. Investigations did not reveal an infectious etiology in the two presentations. The patient improved with supportive care and withdrawal of the offending agent. In the two admissi

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Walsh, Karl, Isabel Hughes, and Baljit Dheansa. "Management of chemical burns." British Journal of Hospital Medicine 83, no. 3 (2022): 1–12. http://dx.doi.org/10.12968/hmed.2020.0056.

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Chemical burns represent a small number of burn injuries in the UK. They have the potential to be life-threatening with serious aesthetic and functional consequences, accounting for 30% of all deaths from burns. Chemical burns are caused by corrosive agents (acids and alkali) leading to extensive tissue damage. Understanding the pathophysiology of a chemical burn injury and identifying the nature of the offending agent is important for effective management. Prompt assessment and management of chemical injuries is vital to reduce the deleterious effect of the compound involved. This article rev

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Butt, Muhammad Umer, Ahmad Jabri, and Samy Claude Elayi. "Azithromycin-Induced Thrombocytopenia: A Rare Etiology of Drug-Induced Immune Thrombocytopenia." Case Reports in Medicine 2019 (July 8, 2019): 1–3. http://dx.doi.org/10.1155/2019/6109831.

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Drug-induced thrombocytopenia requires a high suspicion for diagnosis and a broad investigation to exclude other etiologies of low platelets. Cessation of the offending agent often results in recovery of platelet counts. Many medications are known to cause a degree of thrombocytopenia. We present a rare case of severe thrombocytopenia associated with administration of azithromycin.

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McEver, William. "Pulmonary Vein Isolation Ablation as An Indirect Treatment for Torsades De pointes." Clinical Case Reports and Clinical Study 2, no. 5 (2021): 1–2. http://dx.doi.org/10.61148/2766-8614/jccrcs/030.

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QT prolongation is a known consequence when using antiarrhythmic drugs such as dofetilide to treat atrial fibrillation (AF). One potential complication of QT prolongation is the life-threatening arrhythmia Torsades de Pointes (TdP), but the prognosis for patients with an acquired long QT syndrome is good if the offending agent is discontinued (1). We present a case in which pulmonary vein isolation (PVI) ablation successfully treated AF and, as a result, indirectly treated dofetilide induced QT prolongation by allowing the discontinuation of the causative agent.

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Coelho, Whellyngton Lima, and Karoline Silva Costa. "IMPACTOS DA LEI Nº 13.869, DE 5 DE SETEMBRO DE 2019, DE ABUSO DE AUTORIDADE NA ATUAÇÃO DOS AGENTES PÚBLICOS." Revista ft 28, no. 133 (2024): 11–12. http://dx.doi.org/10.69849/revistaft/ma10202404111411.

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This is a bibliographical study about Law No. 4,898/65, popularly known as the Abuse of Authority Law, which determines the right to representation and promotes other measures regarding abuses carried out by public agents, in the exercise of or due to its attributions, discussing the historical evolution of the right of representation. The objective of this work is to analyze the impacts of Law No. 13,869, of September 5, 2019 (Abuse of Authority Law) on the actions of public agents. The methodology used was a literature review based on articles published in recent years and case law on the to

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Li, Kayi, and Benjamin Barankin. "Cutaneous Manifestations of Modern Technology Use." Journal of Cutaneous Medicine and Surgery 15, no. 6 (2011): 347–53. http://dx.doi.org/10.2310/7750.2011.10053.

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Background: Modern-age technology is increasingly implicated in traditional dermatologic conditions. Objective: This review provides a concise overview of the cutaneous manifestations from modern technology use. Methods: We describe a case of laptop computer–induced erythema ab igne and provide a review of the literature pertaining to the etiology, clinical features, diagnosis, and management of reported cases of dermatoses resulting from the use of modern technology. Results: Sources of modern technology implicated in the reported cases include video games, laptop computers, personal computer

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Jin, S. J., K. H. Seo, and Y. M. Wi. "The effect of concomitant use of systemic antibiotics in patients with Clostridium difficile infection receiving metronidazole therapy." Epidemiology and Infection 146, no. 5 (2018): 558–64. http://dx.doi.org/10.1017/s0950268818000390.

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AbstractManagement of Clostridium difficile infection (CDI) involves discontinuation of the offending antibiotic agent as soon as possible. However, the ongoing infection does not allow discontinuation of the offending antibiotic. We aimed to retrospectively investigate the predictors of treatment failure and impact of the concomitant use of systemic antibiotics in patients receiving metronidazole therapy. This study was conducted among patients hospitalised at a second care academic hospital from January 2013 to December 2014. Eligible patients were identified by reviewing stool toxin enzyme

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Vasanth, Payaswini, Michelle Parmley, Jose Torrealba, and Tamim Hamdi. "Interstitial Nephritis in a Patient with Inflammatory Bowel Disease." Case Reports in Nephrology 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/4260365.

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Tubulointerstitial nephritis in patients with inflammatory bowel disease has been linked to the use of 5-ASA derivatives. Various aspects of this theory have been challenged with a potential role for the underlying autoimmune disorder. Steroids are the mainstay of treatment and mycophenolate mofetil might be an effective alternative. We report a patient who responded well to mycophenolate despite continuing mesalamine, the suspected offending agent.

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Joel Chandranesan, Andrew Stevenson, Samip Master, Olivia Antosz, Breanne PeytonThomas, and Nebu Koshy. "Dasatinib-Induced Rhabdomyolysis in a 33-Year-Old Patient with Chronic Myeloid Leukemia." Case Reports in Hematology 2018 (2018): 1–3. http://dx.doi.org/10.1155/2018/2849869.

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Rhabdomyolysis is a life-threatening syndrome due to breakdown of the skeletal muscle. It can be caused by massive trauma and crush injuries or occur as a side effect of medications. Here, we describe a case of a 33-year-old male with human immunodeficiency virus (HIV) and newly diagnosed chronic myeloid leukemia (CML) with severe life-threatening rhabdomyolysis due to a rare offending agent.

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Hwang, Andrew, Andrew Iskandar, and Constantin A. Dasanu. "Stevens-Johnson syndrome manifesting late in the course of pembrolizumab therapy." Journal of Oncology Pharmacy Practice 25, no. 6 (2018): 1520–22. http://dx.doi.org/10.1177/1078155218791314.

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Pembrolizumab is a humanized antibody that targets programmed cell death receptor-1. This agent is approved for use in the treatment of several malignancies. While pruritus and papulo-erythematous rash are not uncommon with its use, severe reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis are very rare. We present herein a case of Stevens-Johnson syndrome occurring in a patient who had previously tolerated pembrolizumab without significant side effects for seven months. Prompt recognition of Stevens-Johnson syndrome/toxic epidermal necrolysis and discontinuation of the offe

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Mohamed Yasir. H, Reshma Babu, Dhanya Dharman, and Shaiju S Dharan. "A case report on Azathioprine induced hepatotoxicity." World Journal of Biology Pharmacy and Health Sciences 14, no. 3 (2023): 355–58. http://dx.doi.org/10.30574/wjbphs.2023.14.3.0270.

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The most frequent cause of acute liver failure is drug induced liver damage. The lack of diagnostic testes or biomarkers, identification of DILI is difficult one. In most cases DILI was mild and reversible. Azathioprine, is a widely used immunosupressive agent had a nature of causing liver injury but rare. It basically presents with mild symptoms. Azathioprine can cause idiosyncratic liver injury, usually presented with juandice and fatigue and then linked to elevated liver enzymes. It is reversible and typically resolveson cessation of Azathioprine. This case focuses on Azathioprine’s nature

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Mohamed, Yasir. H., Babu Reshma, Dharman Dhanya, and S. Dharan Shaiju. "A case report on Azathioprine induced hepatotoxicity." World Journal of Biology Pharmacy and Health Sciences 14, no. 3 (2023): 355–58. https://doi.org/10.5281/zenodo.8318341.

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The most frequent cause of acute liver failure is drug induced liver damage. The lack of diagnostic testes or biomarkers, identification of DILI is difficult one. In most cases DILI was mild and reversible. Azathioprine, is a widely used immunosupressive agent had a nature of causing liver injury but rare. It basically presents with mild symptoms. Azathioprine can cause idiosyncratic liver injury, usually presented with juandice and fatigue and then linked to elevated liver enzymes. It is reversible and typically resolveson cessation of Azathioprine. This case focuses on Azathioprine’s n

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Shah, Riddhi, Sakshi Agrawal, and Neela Bhuptani. "A clinical study of cutaneous adverse drug reactions." International Journal of Basic & Clinical Pharmacology 6, no. 4 (2017): 919. http://dx.doi.org/10.18203/2319-2003.ijbcp20171104.

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Background: Adverse cutaneous drug reactions pose a diagnostic challenge due to a myriad of clinical manifestations and wide variety of causative agents. Present study aims to record various clinical patterns of adverse drug reactions, their causative agents and to study the pattern of morbidity and mortality in patients with severe cutaneous adverse drug reactions.Methods: 150 patients with adverse cutaneous drug reactions were included who came to Department of Dermatology, Venereology and Leprosy at PDU Govt. Medical College and Hospital, Rajkot, Gujarat from September 2009 to September 201

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Hanna, Ramy, Shih-Fan Sun, and Pryce Gaynor. "A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient." Antibiotics 8, no. 1 (2018): 1. http://dx.doi.org/10.3390/antibiotics8010001.

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Carbapenem agents are advanced derivatives of cephalosporins that are active against bacteria that produce extended spectrum beta lactamases (ESBL). These antibiotics are resistant to enzymatic cleavage, and have good central nervous system penetration. Given this fact, it is not surprising that these drugs have been reported to cause neurological side effects like seizures and encephalopathy. We report a case of a patient on hemodialytic support who had a notable change in mentation and vocal tremor. This was at first attributed to calcineurin toxicity, but after the finding of a normal tacro

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Burnakis, Thomas G. "Inaccurate Assessment of Drug-Induced Thrombocytopenia: Reason for Concern." Annals of Pharmacotherapy 28, no. 6 (1994): 726–29. http://dx.doi.org/10.1177/106002809402800608.

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OBJECTIVE: To report two cases in which patients were reputed to have exhibited thrombocytopenia secondary to the histamine-receptor blocking agent ranitidine. Evaluation and the associated time frame of events failed to confirm these observations. DESIGN: Two case studies. RESULTS: Ranitidine was ordered as part of the therapeutic course of two patients admitted to the medicine service. The development of thrombocytopenia in both patients was attributed to this agent and it was discontinued. In addition to ranitidine, both patients received several other agents with greater potential to cause

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Jose, Aleena, Anuja S Babu, Sampoornna S. Sampoornna S, Sreekutty S. Sreekutty S, Dr J. Nandakumar Dr. J Nandakumar, and Alphonsa Mathew Alphonsa Mathew. "Unmasking the Dangers of Fairness Creams: A Review of Heavy Metal Content and Its Nephrotoxic Effects." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1299–304. https://doi.org/10.35629/4494-100112991304.

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The skin- whitening creams have been a huge part of society for a fair skin complexion. The benchmark of beauty in many parts of the world today has been entrenched in cultural and historical settings for centuries. These creams may pose serious health risks since many contain heavy metals beyond approved levels.Glomerular diseases, acute renal failure due to ATI and ESKD can be manifestations of kidney damage.When a skin-lightening agent causes heavy metal poisoning in the kidneys, the offending product should be discontinued, management of airway and circulation, chelation therapy and excess

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Bae, Hyung Jin, and Younghee Choe. "Esophageal Mucosal Injuries From Drugs, Radiation, and Caustic Agents." Korean Journal of Helicobacter and Upper Gastrointestinal Research 25, no. 2 (2025): 126–33. https://doi.org/10.7704/kjhugr.2025.0023.

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Various factors can lead to esophageal mucosal injury. A thorough patient history is crucial to accurately diagnose esophageal injuries caused by drugs, radiation, and caustic agents. These conditions are often identifiable based on characteristic clinical features, concomitant diseases, and endoscopic findings and do not necessarily require histological confirmation through biopsies. Regardless of the underlying cause, avoiding or minimizing the offending agent is essential for preventing further mucosal damage. In cases where this is unavoidable, such as radiationinduced esophageal injuries,

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Roe, Neil, Jennifer D. Twilla, Benjamin Duhart, and Brian Wheeler. "Breast cancer patient with everolimus-induced angioedema: A rare occurrence with potential for serious consequences." Journal of Oncology Pharmacy Practice 23, no. 4 (2016): 318–20. http://dx.doi.org/10.1177/1078155216639754.

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Background The development of angioedema is a rare yet serious clinical event that may develop due to an adverse drug reaction. Rapid recognition and treatment of this adverse reaction is critical for optimal patient outcomes; however, prevention of this occurrence is preferred. Case report A 59-year-old woman presented to the emergency department with lingual angioedema caused by the addition of everolimus to her medication regimen. The patient improved after withdrawal of the offending agent and standard treatment. Early recognition by healthcare providers and management of everolimus-induce

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Halder, Dishari, Sudip Das, and Abhishek De. "A Clinico-Epidemiological Study of Fixed Drug Eruption with a Special Focus on the Causative Agent and the Clinical Patterns." Indian Dermatology Online Journal 15, no. 2 (2024): 255–58. http://dx.doi.org/10.4103/idoj.idoj_599_22.

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Background: Fixed drug reaction (FDE) is characterized by the development of well-circumscribed, round, erythematous macules and plaques on cutaneous or mucosal surface following ingestion of the offending drug. Aim and Objectives: To study the etiological agents responsible for FDE and to study the clinical patterns of FDE due to different drugs. Materials and Methods: It was a hospital-based observational cross-sectional clinical study. The study period was 24 months. Fifty patients were included. The study was done after a literature search, hypothesis generation, protocol write-up, ethical

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Kumar, Anurup. "Capnocytophaga canimorsus Meningitis – Diagnosis with 16S rDNA PCR when Conventional Methods Failed to Identify the Causative Agent." Clinical Research and Clinical Trials 3, no. 4 (2021): 01–06. http://dx.doi.org/10.31579/2693-4779/025.

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Meningitis whether bacterial or viral, poses many challenges to clinicians as the causative agent is often not found. According to guidelines, it is standard to start empiric treatment before a Cerebrospinal Fluid (CSF) sample is obtained. Meningitis, if not diagnosed and treated early, can lead to high morbidity and mortality rates with serious neurological sequelae. While the most common cases of bacterial meningitis are related to Streptococcus pneumoniae and Neisseria meningitidis, this clinical case report found a rare case of meningitis caused by a zoonotic pathogen, Capnocytophaga canim

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Sreelekshmy, B. S.1 Ranjana S. R.2 Shaiju S. Dharan4 Dhanya Dharman*3. "Ayurvedic Herbal Product Induced Liver Injury: A Case Report." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 423–35. https://doi.org/10.5281/zenodo.10815176.

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<strong>Background:</strong> Ayurveda is one of the traditional medicinal systems. Ayurveda formulations are based on plants, animal extract and minerals. There are 21 varieties of Ayurveda formulations. Ayurvedic compound formulations are mainly divided into two groups; Kasthausadhi (predominantly plant drugs) and Rasausadhi (predominantly metals and minerals). These are manufactured by using classical texts of Ayurveda; Charak Samhita or Susrut Samhita. Drug induced liver injury (DILI) that may occur due to consuming certain medicines. It is an acute or chronic response to a natural or manuf

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Long, Erin, Juan Camilo Ruiz, Julena Foglia, Kamen Valchanov, and Andrew Meikle. "Recognition, treatment, and prevention of perioperative anaphylaxis: a narrative review." AIMS Medical Science 9, no. 1 (2022): 32–50. http://dx.doi.org/10.3934/medsci.2022005.

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<abstract> <p>Perioperative anaphylaxis events are allergic reactions which occur in the perioperative period when patients are exposed to a multitude of agents, received anesthesia, and undergo a procedure. These reactions are rare and can be life-threatening, with the common signs being hypotension, hypoxia, elevated airway pressures and urticaria. Perioperative anaphylaxis can be mediated by immunoglobulin E (IgE) or non-IgE mechanisms. Globally, the incidence of reactions and frequency of specific triggers varies considerably. Perioperative anaphylaxis events often result in di

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Kozłowska, K., and J. Małyszko. "Malignancy-associated kidney disease." Progress in Health Sciences 6, no. 1 (2016): 0. http://dx.doi.org/10.5604/01.3001.0009.5255.

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Malignancy or its treatment affect kidney in several ways. The most common are acute kidney injury and chronic kidney disease. Other form of kidney diseases can also be present such as nephrotic syndrome, tubulointerstitial nephritis, thrombotic microangipathy etc. In addition, electrolyte abnormalities such as hypercalcemia, hyponatremia and hypernatremia, hypokalemia and hyperkalemia, and hypomagnesemia. are observed. Treatment of malignancy associated kidney disease is usually symptomatic. Cessation of the offending agent or other supportive measures if needed i.e. renal replacement therapy

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Suresh, Jayasurya, and Nidheesh Chandran R. "Chronic urticaria in a two year old child: a diagnostic dilemma." International Journal of Contemporary Pediatrics 7, no. 9 (2020): 1926. http://dx.doi.org/10.18203/2349-3291.ijcp20203657.

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A 2 year old child presented with history of recurrent urticaria for 2 months. The cause was initially idiopathic. On close questioning about diet and observation it was found that mother started using a coriander based masala powder 2 months back and it was found that the child was allergic to coriander. Chronic urticaria should be dealt with extreme caution and careful elicitation of history for the offending agent should be taken in a case of urticaria which poses as a diagnostic dilemma.

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Meenakshi, R., S. Nitya, S. Kiruthika, and M. Shanthi. "Fixed drug eruption associated with fixed combination of fluoroquinolone-nitroimidazole." International Journal of Basic & Clinical Pharmacology 10, no. 5 (2021): 576. http://dx.doi.org/10.18203/2319-2003.ijbcp20211656.

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Fixed drug eruptions (FDE) are cutaneous adverse drug reaction characterized by well demarcated erythematous plaques which on removal of the offending agent resolves with residual hyperpigmentation patches at the site. FDE to nitroimidazoles and fluoroquinolones have nevertheless been infrequently reported. Awareness about the adverse reaction to the fluoroquinolone-nitroimidazole combination drug and also the likelihood of recurrence with same or similar drugs and the possible cross reaction is eminent. Hereby we report one such case of FDE to ciprofloxacin/tinidazole combination.

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Jasti, Vivek Vardhan, Jay Anderson, and Ifa Abdujelil. "Angioedema without urticaria after recent initiation of celecoxib." BMJ Case Reports 16, no. 9 (2023): e255446. http://dx.doi.org/10.1136/bcr-2023-255446.

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Angioedema is potentially life-threating swelling of integument and mucosa that has multiple potential aetiologies with varying mechanisms. Drug-induced angioedema is often easily correlated with the offending agent and can be prevented with discontinuation of the medication. Many medications have now been implicated in drug-induced angioedema but the two most common are ACE inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs). This case highlights severe angioedema secondary to celecoxib and reviews varying aetiologies of angioedema and NSAID hypersensitivity reactions.

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Fox, Ashley N., Brooke E. Nation, Marcus Tad Autry, and Peter N. Johnson. "Possible role for acetylcysteine as a treatment for acute liver failure secondary to antitubercular medication use." American Journal of Health-System Pharmacy 77, no. 18 (2020): 1482–87. http://dx.doi.org/10.1093/ajhp/zxaa202.

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Abstract Purpose Drug-induced liver injury (DILI) that progresses to acute liver failure (ALF) has a high mortality rate, and therapeutic options are limited. Acetylcysteine has a labeled indication for use as an antidote for acetaminophen toxicity and has also been used with limited success in treatment of non–acetaminophen-induced liver injury, with small clinical trials indicating an increase in transplant-free survival. Recommendations for management of non–acetaminophen-induced DILI include withdrawal of the offending agent and supportive care. Treatment guidelines generally discourage a

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Safadi, Sami, Michael Mao, and John J. Dillon. "Ceftriaxone-Induced Acute Encephalopathy in a Peritoneal Dialysis Patient." Case Reports in Nephrology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/108185.

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Encephalopathy is a rare side effect of third and fourth generation cephalosporins. Renal failure and preexisting neurological disease are notable risk factors. Recognition is important as discontinuing the offending agent usually resolves symptoms. We present a case of acute encephalopathy in a patient with end stage renal disease (ESRD) treated with peritoneal dialysis (PD) who received intravenous ceftriaxone for peritonitis. This case illustrates the potential severe neurologic effects of cephalosporins, which are recommended by international guidelines as first-line antimicrobial therapy

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Patel, Rahul, Ahmed Hassan, Hayle Scanlan, et al. "Acute Liver Failure Induced by Provitalize: A Menopause Supplement Concocted From Herbs & Probiotics." ACG Case Reports Journal 11, no. 9 (2024): e01509. http://dx.doi.org/10.14309/crj.0000000000001509.

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ABSTRACT Drug-induced liver injury is one of the most common causes of acute liver failure in the Western world. Despite discontinuation of the offending agent, it can still tax a grim prognosis. We describe a case of a menopausal woman taking a herbal supplement called “Provitalize” to relieve hot flashes and bloating. This is the first case report of liver injury from this supplement. She initially presented with mild jaundice and elevated transaminases. Unfortunately, she rapidly progressed to encephalopathy, experienced multiorgan failure, and then died.

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Downes, Kevin J., Molly Hayes, Julie C. Fitzgerald, et al. "Mechanisms of antimicrobial-induced nephrotoxicity in children." Journal of Antimicrobial Chemotherapy 75, no. 1 (2019): 1–13. http://dx.doi.org/10.1093/jac/dkz325.

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AbstractDrug-induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in hospitalized patients and is associated with increased morbidity and mortality in both children and adults. Antimicrobials are one of the most common classes of medications prescribed globally and also among the most common causes of nephrotoxicity. A broad range of antimicrobial agents have been associated with nephrotoxicity, but the features of kidney injury vary based on the agent, its mechanism of injury and the site of toxicity within the kidney. Distinguishing nephrotoxicity caused by an

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&NA;. "Early diagnosis and discontinuation of the offending agent is critical in drug-induced lupus erythematosus." Drugs & Therapy Perspectives 27, no. 12 (2011): 19–22. http://dx.doi.org/10.2165/11606130-000000000-00000.

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Bagheri, Saghar, Dimitrios P. Ntentakis, Maria Emfietzoglou, et al. "Sterile Intraocular Inflammation Following Intravitreal Injections: Pathogenesis, Clinical Features, and Management." International Ophthalmology Clinics 65, no. 3 (2025): 63–70. https://doi.org/10.1097/iio.0000000000000580.

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Intravitreal injections have revolutionized the treatment of retinal diseases, yet there are possible complications, such as noninfectious intraocular inflammation, a complication that may threaten vision and mimic infectious endophthalmitis. This review synthesizes current knowledge on inflammation after intravitreal therapy, with particular focus on sterile intraocular inflammation and retinal vasculitis associated with anti-VEGF agents such as brolucizumab and newer complement inhibitors like pegcetacoplan. The pathogenesis is multifactorial, involving patient-specific immune responses, dru

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Commins, Natalie, Deloshaan Subhaharan, Andrew Dettrick, and Desmond Patrick. "Mercaptopurine-induced Sweet’s syndrome." BMJ Case Reports 17, no. 2 (2024): e259278. http://dx.doi.org/10.1136/bcr-2023-259278.

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Sweet’s syndrome is an acute febrile neutrophilic dermatosis. Drug-induced Sweet’s syndrome typically occurs soon after drug administration, with rapid resolution of symptoms with cessation of the offending agent. We report a man in his early 40s who presented with fever and widespread erythematous rash on a background of recently diagnosed mild stricturing ileal Crohn’s disease. He was commenced on 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration of neutrophils in the upper dermis, dermal oedema, eosinophils and fibrin deposition. Symptoms rapidly im

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