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Journal articles on the topic '(OH) Vitamin D'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Grey, Vijaylaxmi, Larry Lands, Harpreet Pall, and Donna Drury. "Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis." Journal of Pediatric Gastroenterology and Nutrition 30, no. 3 (2000): 314–19. http://dx.doi.org/10.1002/j.1536-4801.2000.tb02733.x.

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ABSTRACTBackground:Patients with cystic fibrosis are at risk for malabsorption of fat‐soluble vitamins, and those with low 25‐OH vitamin D levels have a higher risk of low bone mineral density and long‐term skeletal complications. It is currently recommended that vitamins A and E be monitored yearly; however, no recommendations exist for 25‐OH vitamin D. Because all three vitamins are fat‐soluble, the hypothesis in the current study was that low levels of vitamins A and E could identify patients at risk for low 25‐OH vitamin D, so that 25‐OH vitamin D measurements could be obtained in only sel

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2

Uğur, Sevcan, Cahit Kaçar, and Sebahat Özdem. "The importance of parathormone in determining the deficiency of vitamin D." Turkish Journal of Biochemistry 44, no. 5 (2019): 585–93. http://dx.doi.org/10.1515/tjb-2018-0150.

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Abstract Background To evaluate the association of parathormone with vitamin D and to find a threshold value for vitamin D. Material and methods This descriptive study included 11,753 (2352 males, 9401 females) patients from University hospital and 25-OH vitamin D and PTH levels were evaluated. Results The mean parathormone level was 49.33 ± 22.39 pg/mL. 18.7% of the patients had hyperparathyroidism. 77.4% of the patients had low 25-OH D vitamins. There was a negative correlation between serum parathormone levels and 25-OH vitamin D levels. The minimum 25-OH vitamin D level to keep PTH below 6

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Varsamis, Nikolaos, Georgios A. Christou, Christos Derdemezis, Alexandros Tselepis, and Dimitrios Kiortsis. "The Associations of Dietary Vitamin K Intake and Circulating Vitamin 25(OH)D with Serum Lipoprotein Levels: The Vitamin Deficiency Matters." Hormone and Metabolic Research 55, no. 03 (2023): 196–204. http://dx.doi.org/10.1055/a-2020-2080.

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AbstractA synergistic interplay between vitamins K and D appears to exist. We aimed to investigate for the first time whether the associations of dietary vitamin K intake and circulating 25(OH)D with serum lipoprotein levels are influenced by the existence of deficiency of either or both vitamins K and D. Sixty individuals [24 males, 36(18–79) years old] were examined. Vitamin deficiency of K1 and D were defined as vitamin K1 intake/body weight (BW)<1.00 μg/kg/day and circulating 25(OH)D<20 ng/ml, respectively. In individuals with vitamin K1 deficiency, the vitamin K1 intake/BW correlate

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4

Brown, Alex J., Adriana Dusso, and Eduardo Slatopolsky. "Vitamin D." American Journal of Physiology-Renal Physiology 277, no. 2 (1999): F157—F175. http://dx.doi.org/10.1152/ajprenal.1999.277.2.f157.

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The vitamin D endocrine systems plays a critical role in calcium and phosphate homeostasis. The active form of vitamin D, 1,25-dihydroxyvitamin D3[1,25(OH)2D3], binds with high affinity to a specific cellular receptor that acts as a ligand-activated transcription factor. The activated vitamin D receptor (VDR) dimerizes with another nuclear receptor, the retinoid X receptor (RXR), and the heterodimer binds to specific DNA motifs (vitamin D response elements, VDREs) in the promoter region of target genes. This heterodimer recruits nuclear coactivators and components of the transcriptional preini

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Rph., Saad Ali Al Arfaj Rph. Saad Ali Al Arfaj, Mohammed Khalid Al Rabiah Rph. Mohammed Khalid Al Rabiah Rph., and Ismail Haider Baqtayyan Rph. Ismail Haider Baqtayyan Rph. "Vitamin D status and consequences of vitamin D deficiency." International Journal of Innovative Research in Engineering & Multidisciplinary Physical Sciences 2, no. 5 (2014): 1–5. https://doi.org/10.5281/zenodo.10114132.

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Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are presently diagnosed because the useful repute indicator for diet D.Evidence is reviewed that suggests that serum 25(OH)D3 concentrations of < eighty nmol/L are related to decreased calcium absorption, osteoporosis, and accelerated fracture risk. For popular older individuals, supplemental oral intakes of ~1300 IU/d are required to obtain the lower end of the best range.Evidence of considerable issues in recurring medical size of serum 25(OH)D3 concentrations amongst sufferers is cited.There is extremely good want for standardization a

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Dusso, Adriana S., Alex J. Brown, and Eduardo Slatopolsky. "Vitamin D." American Journal of Physiology-Renal Physiology 289, no. 1 (2005): F8—F28. http://dx.doi.org/10.1152/ajprenal.00336.2004.

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The vitamin D endocrine system plays an essential role in calcium homeostasis and bone metabolism, but research during the past two decades has revealed a diverse range of biological actions that include induction of cell differentiation, inhibition of cell growth, immunomodulation, and control of other hormonal systems. Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)2D]. This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible

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Ramasamy, Indra. "Vitamin D Metabolism and Guidelines for Vitamin D Supplementation." Clinical Biochemist Reviews 41, no. 3 (2020): 103–26. http://dx.doi.org/10.33176/aacb-20-00006.

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Vitamin D is essential for bone health and is known to be involved in immunomodulation and cell proliferation. Vitamin D status remains a significant health issue worldwide. However, there has been no clear consensus on vitamin D deficiency and its measurement in serum, and clinical practice of vitamin D deficiency treatment remains inconsistent. The major circulating metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), is widely used as a biomarker of vitamin D status. Other metabolic pathways are recognised as important to vitamin D function and measurement of other metabolites may become

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8

Oleröd, Göran, Lillemor Mattsson Hultén, Ola Hammarsten, and Eva Klingberg. "The variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D status." Endocrine Connections 6, no. 2 (2017): 111–20. http://dx.doi.org/10.1530/ec-16-0078.

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Purpose Serum 25-hydroxy vitamin D [25(OH)D] varies greatly with season at northern latitudes. The purpose of this study was to determine if the seasonal variations in serum total 25(OH)D are followed by a concomitant variation in free 25(OH)D or if the variation is damped by alterations in the binding capacity of DBP. Methods Serum was collected from 540 healthy blood donors (60% men; mean age 41 ± 13 years) during 12 months and analyzed for total 25(OH)D, directly measured free 25(OH)D, vitamin D-binding protein (DBP) and albumin. Calculated free 25(OH)D was estimated. Results The UV-B radia

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Jovičić, Snežana, Svetlana Ignjatović, and Nada Majkić-Singh. "Biochemistry and metabolism of vitamin D / Biohemija i metabolizam vitamina D." Journal of Medical Biochemistry 31, no. 4 (2012): 309–15. http://dx.doi.org/10.2478/v10011-012-0028-8.

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Summary Vitamin D is not technically a vitamin, since it is not an essential dietary factor. It is rather a prohormone produced photochemically in the skin from 7-dehydrocholesterol. Vitamin D and its metabolites may be categorized as either cholecalciferols or ergocalciferols. Cholecalciferol (vi - tamin D3) is the parent compound of the naturally occurring family and is produced in the skin from 7-dehydrocholesterol on exposure to the ultraviolet B portion of sunlight. Vitamin D2 (ergocalciferol), the parent compound of the other family, is manufactured by irradiation of ergosterol produced

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Putri, Krisna, Yusrawati, and Rifa Karmia Hudila. "Correlation between vitamin D intake with level of 25-hydroxy vitamin D serum maternal." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 652–56. https://doi.org/10.5281/zenodo.8405947.

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Vitamin D deficiency is a health problem that is of concern at this time. During pregnancy, vitamin D is associated with fetal growth and development, wherein the 25(OH)D level of the fetus is completely dependent on the mother's supply. This study aims to examine the relationship between vitamin D intake and maternal serum 25(OH)D levels. This research uses a cross-sectional design. Data collection was carried out in samples at Hermina Hospital, BMC and Army Hospital in June-December 2022. The sampling technique used consecutive sampling, totaling 40 term pregnant women. Data collection w

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Lugasi, Andrea, Márta Bakacs, Andrea Zentai, Viktória Anna Kovács, and Éva Martos. "Hungarian Diet and Nutritional Status Survey – The OTAP2009 study. III. Vitamin intake of the Hungarian population." Orvosi Hetilap 153, no. 28 (2012): 1106–17. http://dx.doi.org/10.1556/oh.2012.29377.

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For the healthy status the adequate intake of vitamins is essential. Aim and method: The Hungarian Diet and Nutritional Status Survey – joining to the European Health Interview Survey – studied the dietary habits of the Hungarian population. This work presents the vitamins intake. Results: The intake of all water soluble vitamins, vitamin E and D were significantly higher in men than in women. Favourable phenomena were the increased β-carotene and vitamin C intakes in men and women compared to the earlier data. Intakes of vitamin C, B1-, B2-, B6- and B12, and niacin meet the recommendations. C

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12

Lee, Seunghye, Hyejin Chung, Sehyun Jung, et al. "24,25-Dihydroxy Vitamin D and Vitamin D Metabolite Ratio as Biomarkers of Vitamin D in Chronic Kidney Disease." Nutrients 15, no. 3 (2023): 578. http://dx.doi.org/10.3390/nu15030578.

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The appropriate management of vitamin D deficiency and hyperparathyroidism is essential to prevent metabolic bone disorder (MBD) and cardiovascular diseases in chronic kidney disease (CKD). Recently, the 24,25-dihydroxyvitamin D [24,25(OH)2D] and vitamin D metabolite ratio (VMR), i.e., the ratio of 24,25(OH)2D to 25-hydroxyvitamin D [25(OH)D], have emerged as biomarkers of vitamin D level. We analyzed the usefulness of vitamin D biomarkers for the evaluation of MBD in patients with CKD. We analyzed blood and urine samples from 208 outpatients with CKD stage G2–G5. 25(OH)D showed a poor correla

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REPRODUCTIVE, ENDOCRINOLOGY. "Vitamin D for the prevention of disease: an Endocrine Society clinical practice guideline (2024)." REPRODUCTIVE ENDOCRINOLOGY, no. 73 (October 18, 2024): 74–78. https://doi.org/10.18370/2309-4117.2024.73.74-78.

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<strong>Background</strong>. Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety of common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, and infectious diseases. Although a causal link between serum 25(OH)D concentrations and many disorders has not been clearly established, these associations have led to widespread supplementation with vitamin D and increased laboratory testing for 25(OH)D in the general population. The benefit-risk ratio of this increase in vitamin D use is not clear, a

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Sollid, Stina T., Moira Y. S. Hutchinson, Vivian Berg, et al. "Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D." European Journal of Endocrinology 174, no. 4 (2016): 445–52. http://dx.doi.org/10.1530/eje-15-1089.

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ObjectiveTo determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.Design, patients and interventionsA randomized controlled trial with 20 000 IU of vitamin D3per week or placebo for 12 months was designed. A total of 472 subjects, 236 in each of the intervention groups, were included in the analyses.Main outcome measuresBaseline serum concentrations and increases in serum

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15

Francic, Vito, Stan R. Ursem, Niek F. Dirks, et al. "The Effect of Vitamin D Supplementation on its Metabolism and the Vitamin D Metabolite Ratio." Nutrients 11, no. 10 (2019): 2539. http://dx.doi.org/10.3390/nu11102539.

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25-hydroxyvitamin D (25(OH)D) is commonly measured to assess vitamin D status. Other vitamin D metabolites such as 24,25-dihydroxyvitamin D (24,25(OH)2D) provide additional insights into vitamin D status or metabolism. Earlier studies suggested that the vitamin D metabolite ratio (VMR), calculated as 24,25(OH)2D/25(OH)D, could predict the 25(OH)D increase after vitamin D supplementation. However, the evidence for this additional value is inconclusive. Therefore, our aim was to assess whether the increase in 25(OH)D after supplementation was predicted by the VMR better than baseline 25(OH)D. Pl

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Kaminsky, O. V. "Vitamin D dosage." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, no. 5 (2022): 435–42. http://dx.doi.org/10.22141/2224-0721.17.5.2021.241524.

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Despite its historical name, vitamin D is not a vitamin at all but a hormone that, when activated, is a metabolically active steroid fat-soluble hormone that acts on cellular receptors. Vitamin D hormone is synthesized endogenously and then metabolized in the body, provi-ding that there are the necessary precursors and some factors — the effects of ultraviolet light on the skin. At the same time, vitamins themselves are nutrients, co-factors of biochemical reactions that are not synthesized in the body and cannot interact with receptors, consumed with food, so the hormone D is not a vitamin. D

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Makhsudov, Javidan, and Resul Yılmaz. "Vitamin D Deficiency in Children." Chronicles of Precision Medical Researchers 1, no. 1 (2020): 8–19. https://doi.org/10.5281/zenodo.7854218.

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Vitamin D is a prohormone that plays a key role in calciumphosphate metabolism and shows its target effects in the intestine, kidneys and musculoskeletal system. In recent years, it was reported that Vitamin D deficiency and insufficiency are related with many chronic diseases such as widespread cancers, cardiovascular diseases, metabolic syndromes, infectious diseases and autoimmune diseases. Vitamin D deficiency is also a defined risk factor for osteoporosis, falls and fractures. Vitamin D deficiency is now recognized as a global epidemic. 25(OH) Vitamin D levels under 20 ng/mL is accepted a

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18

Kanike, Neelakanta, Krupa Gowri Hospattankar, Amit Sharma, Sarah Worley, and Sharon Groh-Wargo. "Prevalence of Vitamin D Deficiency in a Large Newborn Cohort from Northern United States and Effect of Intrauterine Drug Exposure." Nutrients 12, no. 7 (2020): 2085. http://dx.doi.org/10.3390/nu12072085.

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Vitamin D is not only a vital element in bone health but is also a prohormone. Data regarding distribution of vitamin D status among preterm and term neonates in the United States are limited. There are no data on the effect of intrauterine drug exposure on vitamin D status. Our objective was to determine the distribution of vitamin D levels among preterm and term neonates and the effect of intrauterine illicit drug exposure. We did a retrospective chart review of neonates admitted from 2009 to 2016 to our neonatal intensive care unit with serum 25-hydroxycholecalciferol (25[OH]D) levels measu

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Zelzer, Sieglinde, Andreas Meinitzer, Dietmar Enko, et al. "Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients." Nutrients 16, no. 6 (2024): 839. http://dx.doi.org/10.3390/nu16060839.

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Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR), i.e., 24,25(OH)2D divided by 25(OH)D, may indicate high vitamin D requirements and provide additional diagnostic information beyond serum 25(OH)D. We, therefore, evaluated whether the classification of “functional vitamin D deficiency”, i.e., 25(OH)D below 50 nmol/L, 24,25(OH)2D below 3 nmol/L an

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Mihailović-Vučinić, Violeta, Svetlana Ignjatović, Aleksandra Dudvarski-Ilić, et al. "The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi." Journal of Medical Biochemistry 31, no. 4 (2012): 339–46. http://dx.doi.org/10.2478/v10011-012-0015-0.

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Summary Recently published data indicate that vitamin D abnormalities are common in sarcoidosis patients. The purpose of this study was to compare serum vitamin 25(OH)D levels among sarcoidosis patients with different clinical cour - ses of the disease. The study also included the first observations on cognitive functions (i.e. depression and fatigue syndrome) in relation to vitamin D deficiency in sarcoidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measured using the Elecsys® Vitamin D total test. A total of 226 patients with bi

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Meier, C., and M. E. Kraenzlin. "Sinn und Unsinn der Vitamin-D- Bestimmung." Osteologie 24, no. 04 (2015): 225–30. http://dx.doi.org/10.1055/s-0037-1622070.

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ZusammenfassungIn den letzten Jahren ist das Interesse an Vitamin D stark gestiegen, dies aufgrund der nachgewiesenen Wirkung von Vitamin D auf den Mineralstoffwechsel und die neuromuskulären Funktionen, aber auch aufgrund anderer, pleiotroper Effekte. Die Konsequenz dieses gesteigerten Interesses spiegelt sich in der zunehmenden Verordnung für die Bestimmung des 25(OH)-Vitamin-D-Spiegels wider, um den Vitamin-D-Versorgungsstatus zu erfassen und um über eine allfällige Vitamin-D-Supplementation zu entscheiden. Die 25(OH)D-Messung wird aber durch verschiede Faktoren beeinflusst. Einerseits die

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Pusparini, Pusparini. "DEFISIENSI VITAMIN D TERHADAP PENYAKIT (Vitamin D Deficiency and Diseases)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 1 (2018): 90. http://dx.doi.org/10.24293/ijcpml.v21i1.1265.

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It has been estimated that deficiency and insufficiency of Vitamin D affect one bilion people worldwide. Vitamin D deficiency can befound not only in countries with four (4) seasons, but also in countries with sunlight exposure all year long The objective of this studywas to know whether vitamin D deficiency can occur in Indonesia as well and to explore the role of vitamin D in people‘s health, althoughIndonesia is a country in the equator region. To avoid long term negative health consequences 25 hydroxyvitamin D/25 (OH) D serumlevel should be between 30 and 100 ng/mL. The main source of vita

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Wilson, Louise R., Laura Tripkovic, Kathryn H. Hart, and Susan A. Lanham-New. "Vitamin D deficiency as a public health issue: using vitamin D2or vitamin D3in future fortification strategies." Proceedings of the Nutrition Society 76, no. 3 (2017): 392–99. http://dx.doi.org/10.1017/s0029665117000349.

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The role of vitamin D in supporting the growth and maintenance of the skeleton is robust; with recent research also suggesting a beneficial link between vitamin D and other non-skeletal health outcomes, including immune function, cardiovascular health and cancer. Despite this, vitamin D deficiency remains a global public health issue, with a renewed focus in the UK following the publication of Public Health England's new Dietary Vitamin D Requirements. Natural sources of vitamin D (dietary and UVB exposure) are limited, and thus mechanisms are needed to allow individuals to achieve the new die

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Anak, Agung Ayu Ratih Dharmaiswari, and Kadek Sumantara Artha I. "Effectivity of Vitamin D in Preventing Breast Cancer and Evaluation of 25(OH)D Examination As A Laboratory Screening Tool." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 696–701. https://doi.org/10.5281/zenodo.15347969.

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Vitamin D is currently associated with many diseases, not only bone health but also in autoimmune diseases, cancer, and neurological disorders. This study focuses on the mechanism relation vitamin D on breast cancer, especially with regard to estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-positive (HER 2+) cancers. Therapeutic supplementation is a commonly used approach to increase vitamin D levels. The effects of vitamin D have been investigated in various aspects, including regulation of cell growth and differentiation, apoptosis, intercellular contact, angioge

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Au, Lauren E., Christina D. Economos, Elizabeth Goodman, Aviva Must, Virginia R. Chomitz, and Jennifer M. Sacheck. "Vitamin D intake and serum vitamin D in ethnically diverse urban schoolchildren." Public Health Nutrition 15, no. 11 (2012): 2047–53. http://dx.doi.org/10.1017/s1368980012003217.

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AbstractObjectiveLow serum vitamin D, which largely affects ethnic minorities, is associated with obesity and other chronic diseases. Little is known about racial/ethnic differences in intake, particularly in children, or if any differences are associated with differences in serum 25-hydroxyvitamin D (25(OH)D). The objective of the present study was to determine whether racial/ethnic differences in dietary vitamin D intake exist and whether they explain differences in 25(OH)D.DesignVitamin D intakes (Block Kids 2004 FFQ) and 25(OH)D were measured. Race/ethnicity was parent-reported (white (37·

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Sari, Dina Keumala, Liza Meutia Sari, Lidya Imelda Laksmi, and Farhat Farhat. "The Use of 25-hydroxyvitamin D Saliva Test to Replace Vitamin D Serum Blood Test in Healthy People." Open Access Macedonian Journal of Medical Sciences 9, T3 (2021): 40–43. http://dx.doi.org/10.3889/oamjms.2021.6329.

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BACKGROUND: Routine examination of Vitamin D levels is carried out by checking serum 25-hydroxyvitamin D (25[OH]D) levels which indicate circulating Vitamin D levels. While serum 1.25(OH)D levels are less frequently performed, although serum 1.25(OH)D levels represent the active form of Vitamin D be a substitute for checking Vitamin D levels. AIMS: This study aims to see the correlation between Vitamin D levels, namely, 25(OH)D and 1.25(OH)D saliva, which correlate with serum 25(OH)D and 1.25(OH)D levels so that the examination of salivary Vitamin D levels can be a substitute for checking seru

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Bikle, Daniel. "Nonclassic Actions of Vitamin D." Journal of Clinical Endocrinology & Metabolism 94, no. 1 (2009): 26–34. http://dx.doi.org/10.1210/jc.2008-1454.

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Abstract Context: Vitamin D receptors are found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. These nonclassic tissues are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)2D. Furthermore, many of these tissues also contain the enzyme CYP27B1 capable of producing 1,25(OH)2D from the circulating form of vitamin D. This review was intended to highlight the actions of 1,25(OH)2D in several of these tissues but starts with a review of vitamin D production, metabolism, and molecular mechanism. Evidence Acq

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Gomes, Fabio, Nick Shaw, Karen Whitfield, Pieter Koorts, Helen McConachy, and Amitha Hewavitharana. "EFFECT OF PASTEURISATION ON THE CONCENTRATIONS OF VITAMIN D COMPOUNDS IN DONOR BREAST MILK." Archives of Disease in Childhood 101, no. 9 (2016): e2.19-e2. http://dx.doi.org/10.1136/archdischild-2016-311535.26.

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AimBreastmilk is considered the most important nutrient and source of supplementation for both term and preterm infants.1 It is composed of many important nutrients, including vitamin D.2 The content of this vitamin in breast milk is usually low, even for lactating mothers with adequate vitamin D status.2 3 Preterm infants are at the great risk of vitamin D deficiency due to decreased transplacental transfer.4 Premature infants are the main recipients of pasteurised donor human milk (PDHM), when their mothers are unable to provide their own.This study aims to evaluate the effect of pasteurisat

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Shin, Hye Ran, Hyeon Ju Park, and Sun Yung Ly. "Optimal Serum 25(OH)D Level and Vitamin D Intake in Young Korean Women." Nutrients 14, no. 22 (2022): 4845. http://dx.doi.org/10.3390/nu14224845.

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Vitamin D status is essential for preventing bone disease. Young Korean women have the highest vitamin D deficiency prevalence compared with other demographic groups. This study aimed to establish the optimal vitamin D intake level for maintaining an adequate serum 25-hydroxyvitamin D (25[OH]D) level by season in young Korean women (mean age: 23.1 years). Each participant (wintertime, n = 101; summertime, n = 117) completed a lifestyle survey, dietary record, bone mineral density, and biochemical tests. Seasonal factors impacting 25(OH)D were identified, vitamin D intake for sufficient 25(OH)D

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Pang, Xuehong, Zhenyu Yang, Jie Wang, et al. "Relationship between Serum 25OH-Vitamin D2 Level and Vitamin D Status of Children Aged 3–5 Years in China." Nutrients 13, no. 11 (2021): 4135. http://dx.doi.org/10.3390/nu13114135.

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Background: Vitamin D deficiency is prevalent globally and there is lack of evidence as to how 25(OH)D2 contributes to vitamin D status. The aim of this study was to describe vitamin D status and to assess the role of vitamin D2, a dietary vitamin D source, against the vitamin D status of children aged 3–5 years in China. Methods: Data were extracted from the Chinese National Nutrition and Health Surveillance (CNNHS) in 2013. The concentration of serum 25(OH)D2 and 25(OH)D3 was measured by using LC-MS/MS. Results: A total of 1435 subjects were enrolled and serum 25(OH)D were analyzed. The prev

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Vičič, Vid, Andreja Kukec, Saša Kugler, Ksenija Geršak, Joško Osredkar, and Ruža Pandel Mikuš. "Assessment of Vitamin D Status in Slovenian Premenopausal and Postmenopausal Women, Using Total, Free, and Bioavailable 25-Hydroxyvitamin D (25(OH)D)." Nutrients 14, no. 24 (2022): 5349. http://dx.doi.org/10.3390/nu14245349.

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The objective of our study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. A cross-sectional study was carried out between 1 March 2021 and 31 May 2021. A total of 319 healthy women from the Central Slovenian region aged between 44 and 65 were recruited; 176 were included in the final analysis. The vitamin D status was determined by measuring the total 25-Hydroxycholecalciferol (25(OH)D) concentration, vitamin D binding protein (DBP), and albumin and calculating the bioavailable 25(OH)D and free 25(OH)D. For the calculation of bioavailab

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Kim, Hyun-Ki, Hye Jin Chung, Hương Giang Lê, Byoung-Kuk Na, and Min-Chul Cho. "Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers." PLOS ONE 16, no. 2 (2021): e0246541. http://dx.doi.org/10.1371/journal.pone.0246541.

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Background Vitamin D status is presently assessed by measuring total serum concentration of 25-hydroxyvitamin D [25(OH)D]. However, 25(OH)D concentration alone might not accurately reflect vitamin D status owing to its weak relationship with various clinical indices and inconsistency across races. Recently, 24,25-dihydroxyvitamin D [24,25(OH)2D] and vitamin D metabolite ratio [VMR; ratio of 24,25(OH)2D to 25(OH)D] have emerged as vitamin D biomarkers. The present study aimed to determine the values of 24,25(OH)2D and VMR in healthy Koreans and compare them with other vitamin D biomarkers, incl

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Allison, Richard J., Abdulaziz Farooq, Anissa Cherif, Bruce Hamilton, Graeme L. Close, and Mathew G. Wilson. "Why don’t serum vitamin D concentrations associate with BMD by DXA? A case of being ‘bound’ to the wrong assay? Implications for vitamin D screening." British Journal of Sports Medicine 52, no. 8 (2017): 522–26. http://dx.doi.org/10.1136/bjsports-2016-097130.

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BackgroundThe association between bone mineral density (BMD) and serum25-hydroxyvitamin D (25(OH)D) concentration is weak, particularly in certain races (eg, BlackAfrican vs Caucasian) and in athletic populations. We aimed to examine if bioavailable vitamin D rather than serum 25(OH)D was related to markers of bone health within a racially diverse athletic population.MethodsIn 604 male athletes (Arab (n=327), Asian (n=48), Black (n=108), Caucasian (n=53) and Hispanic (n=68)), we measured total 25(OH)D, vitamin D-binding protein and BMD by DXA. Bioavailable vitamin D was calculated using the fr

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Yao, Pang, Liang Sun, Ling Lu, et al. "Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation." Journal of Clinical Endocrinology & Metabolism 102, no. 1 (2016): 100–110. http://dx.doi.org/10.1210/jc.2016-2930.

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Abstract Context: Little is known about how genetic and nongenetic factors modify responses of vitamin D supplementation in nonwhite populations. Objective: To investigate factors modifying 25-hydroxyvitamin D [25(OH)D] and bioavailable 25(OH)D [25(OH)DBio] responses after vitamin D3 supplementation. Design, Setting, Participants, and Intervention: In this 20-week, randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency received 2000 IU/d vitamin D3 or placebo. Main Outcome Measures: Serum 25(OH)D, vitamin D-binding protein (VDBP), parathyroid hormone (PTH)

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Rybchyn, Mark S., Myriam Abboud, David A. Puglisi, et al. "Skeletal Muscle and the Maintenance of Vitamin D Status." Nutrients 12, no. 11 (2020): 3270. http://dx.doi.org/10.3390/nu12113270.

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Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cyt

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van Ballegooijen, Adriana J., Joline W. J. Beulens, Charlotte A. Keyzer, et al. "Joint association of vitamins D and K status with long-term outcomes in stable kidney transplant recipients." Nephrology Dialysis Transplantation 35, no. 4 (2019): 706–14. http://dx.doi.org/10.1093/ndt/gfy399.

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Abstract Background Kidney transplant recipients (KTRs) experience substantial survival benefit compared with dialysis patients. However, their mortality and graft failure risk remain high. KTRs are often low in micronutrient status, including vitamins D and K. We investigated the association of both vitamins D and K status, and vitamin D treatment with all-cause mortality and death-censored graft failure. Methods We studied 461 KTRs from a single-centre study at median 6.1 years after transplantation. At baseline, vitamins D and K concentrations were measured by 25-hydroxyvitamin D [25(OH)D]

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Toribio, María José, Feliciano Priego-Capote, Beatriz Pérez-Gómez, et al. "Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women." Nutrients 13, no. 11 (2021): 3747. http://dx.doi.org/10.3390/nu13113747.

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The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determine

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Guo, Jing, Julie A. Lovegrove, and D. Ian Givens. "25(OH)D3-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D3." Proceedings of the Nutrition Society 77, no. 3 (2017): 282–91. http://dx.doi.org/10.1017/s0029665117004062.

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The ability to synthesise sufficient vitamin D through sunlight in human subjects can be limited. Thus, diet has become an important contributor to vitamin D intake and status; however, there are only a few foods (e.g. egg yolk, oily fish) naturally rich in vitamin D. Therefore, vitamin D-enriched foods via supplementing the animals’ diet with vitamin D or vitamin D fortification of foods have been proposed as strategies to increase vitamin D intake. Evidence that cholecalciferol (vitamin D3) and calcifediol (25(OH)D3) content of eggs, fish and milk increased in response to vitamin D3 suppleme

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Takatani, Tomozumi, Yuzuka Kunii, Mamoru Satoh, et al. "Vitamin D Metabolite Ratio in Pregnant Women with Low Blood Vitamin D Concentrations Is Associated with Neonatal Anthropometric Data." Nutrients 14, no. 11 (2022): 2201. http://dx.doi.org/10.3390/nu14112201.

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Existing evidence on the correlation between maternal vitamin D concentrations and birth outcomes is conflicting. Investigation of these associations requires accurate assessment of vitamin D status, especially in individuals with low 25-hydroxyvitamin D (25(OH)D) concentrations. This study examined the correlations between birth outcomes and the maternal vitamin D metabolite ratio (VMR) 1 (defined as the ratio of 24,25(OH)2D3 to 25(OH)D) and VMR2 (defined as the ratio of 3-epi-25(OH)D3 to 25(OH)D) using data from the Japan Environment and Children’s Study at Chiba Regional Center. A total of

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Fields, Jennifer B., Sina Gallo, Jenna M. Worswick, Deanna R. Busteed, and Margaret T. Jones. "25-Hydroxyvitamin D, Vitamin D Binding Protein, Bioavailable 25-Hydroxyvitamin D, and Body Composition in a Diverse Sample of Women Collegiate Indoor Athletes." Journal of Functional Morphology and Kinesiology 5, no. 2 (2020): 32. http://dx.doi.org/10.3390/jfmk5020032.

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Women athletes are at higher risk for bone diseases; yet, information on vitamin D status ((25(OH)D), vitamin D binding protein (VDBP), and bioavailable 25(OH)D is limited. Collegiate athletes (n = 36) from volleyball (WVB), basketball (WBB), and track and field (WTF) were measured for (25(OH)D), VDBP, and bioavailable 25(OH)D; body composition and bone mineral density (BMD); and skin pigmentation. Participants self-reported daily vitamin D intake and sun exposure. One-way analysis of variance analyzed mean differences in measures across sports. Linear regression examined relationships between

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Putz, Zsuzsanna, Tímea Martos, Nóra Németh, et al. "Vitamin D and neuropathy." Orvosi Hetilap 154, no. 51 (2013): 2012–15. http://dx.doi.org/10.1556/oh.2013.29769.

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Diabetes is a widespread disease and, therefore, studies dealing with diabetes and its complications are very important for public health. Numerous reports link vitamin D deficiency to the increased risk of diabetes mellitus and complications such as neuropathy. However, there are limited and conflicting data available on vitamin D deficiency in patients with diabetic peripheral neuropathy. Studies in type 2 diabetics confirmed the relationship between vitamin D deficiency and incidence of neuropathy. Recent reports suggest a relationship between the incidence of plantar ulcers and vitamin D d

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Yaturu, Subhashini, and Jared Davis. "Prevalence of Decreased Vitamin D Levels is High among Veterans with Diabetes and/or CKD." ISRN Endocrinology 2011 (July 18, 2011): 1–4. http://dx.doi.org/10.5402/2011/109458.

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Objective. Vitamin D deficiency is associated with a variety of skeletal and extraskeletal problems. The aim of this study was to evaluate the prevalence of vitamin D deficiency among veterans in sunny Louisiana. Methods. Using the VA computerized patient record system, we searched for all 25 (OH) Vitamin D and 1, 25 (OH) vitamin D levels that were measured between 2007 and 2009. The information collected for each patient included age, body mass index, creatinine, history of diabetes and hypertension, and levels of vitamin D and PTH. We determined the number of individuals who were vitamin D i

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Elmelid, Andrea, Maria Siekkeri Vandikas, Martin Gillstedt, Amra Osmancevic, and Mikael Alsterholm. "The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis." Biomolecules 13, no. 7 (2023): 1018. http://dx.doi.org/10.3390/biom13071018.

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Vitamin D plays an important role in skin inflammation in psoriasis. The beneficial effects of ultraviolet light B (UVB) phototherapy in psoriasis are partly attributed to UVB-induced increase of vitamin D levels. In clinical practice, total 25-hydroxy vitamin D (25(OH)D) levels are measured to assess sufficiency, but it might be more accurate to measure free 25(OH)D levels. The aim of this study was to measure free serum 25(OH)D levels in psoriasis patients before and after phototherapy and to investigate if free 25(OH)D correlates stronger to disease severity than total 25(OH)D. Twenty adult

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Ciuca, Ioana Mihaiela, Liviu Laurentiu Pop, Mihaela Dediu, et al. "Vitamin D(25-OH-cholecalciferol) in Cystic Fibrosis and the Relations with Cholesterol and Proteins." Revista de Chimie 70, no. 9 (2019): 3185–87. http://dx.doi.org/10.37358/rc.19.9.7512.

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Study aimed to assess the level of 25-OH-cholecalciferol(vitamin D) and the relation with cholesterol, proteins and glycaemia levels in patients with cystic fibrosis. 58 patients underwent for the annual evaluations and were tested for vitamin D deficiency, as the centre�s protocol requires, besides dosage of cholesterol, glycaemia and proteins levels. Serum levels of 25-hydroxycholecalciferol were compared to levels of cholesterol, proteins and glycaemia, using Pearson correlation and logistic regression. The average value of 25-OH-cholecalciferol was 22,9 ng/mL, suggesting an important defic

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Wimalawansa, Sunil J. "Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging." Biology 8, no. 2 (2019): 30. http://dx.doi.org/10.3390/biology8020030.

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Recent advances in vitamin D research indicate that this vitamin, a secosteroid hormone, has beneficial effects on several body systems other than the musculoskeletal system. Both 25 dihydroxy vitamin D [25(OH)2D] and its active hormonal form, 1,25-dihydroxyvitamin D [1,25(OH)2D] are essential for human physiological functions, including damping down inflammation and the excessive intracellular oxidative stresses. Vitamin D is one of the key controllers of systemic inflammation, oxidative stress and mitochondrial respiratory function, and thus, the aging process in humans. In turn, molecular a

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Malmstroem, Sofie, Lars Rejnmark, John B. Imboden, Dolores M. Shoback, and Daniel D. Bikle. "Current Assays to Determine Free 25-Hydroxyvitamin D in Serum." Journal of AOAC INTERNATIONAL 100, no. 5 (2017): 1323–27. http://dx.doi.org/10.5740/jaoacint.17-0085.

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Abstract The 25-hydroxylated metabolite of vitamin D is the best clinical indicator of vitamin D status. For many years, emphasis has been on measuring total levels of 25-hydroxyvitamin D [25(OH)D], but recently, interest in measuring free 25(OH)D as a potentially better marker of vitamin D status has arisen. Since the 1980s when the first measurements of free 25(OH)Dwere made, little progress has been made in the development of rapid, reliable methods to determine the levels of free 25(OH)D. For many years, assessment of free 25(OH)D relied on calculations using levels of total 25(OH)D, album

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Dong, Rui, Song Sun, Xiao-Zhou Liu, Zhen Shen, Gong Chen, and Shan Zheng. "Fat-Soluble Vitamin Deficiency in Pediatric Patients with Biliary Atresia." Gastroenterology Research and Practice 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/7496860.

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Objective. To analyze the levels of fat-soluble vitamins (FSVs) in pediatric patients with biliary atresia (BA) before and after the Kasai procedure. Methods. Pediatric patients with obstructive jaundice were enrolled in this study. The FSV levels and liver function before, 2 weeks after, and 1, 3, and 6 months after the Kasai procedure were measured. Results. FSV deficiency was more obvious in patients with BA than in patients with other cholestatic liver diseases, especially vitamin D deficiency. 25-Hydroxy vitamin D (25-(OH)D) deficiency was more pronounced in younger patients before surger

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Susanto, Hendri, Bagus Soebadi, Diah Savitri Ernawati, et al. "Serum vitamin D/25(OH)D associated with toll-like receptor (TLR) 2 expression of immune cells in the saliva of Systemic Lupus Erythematosus: a preliminary study." Journal of Oral Medicine and Oral Surgery 27, no. 2 (2021): 22. http://dx.doi.org/10.1051/mbcb/2020062.

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Objective: Vitamin D deficiency may contribute to Systemic Lupus Erythematosus (SLE) development. Vitamin D may involve in pathogen recognition through Toll-like receptor (TLR) 2 in immune cells in saliva. This study aimed to determine the correlation between serum vitamin D/25(OH)D and TLR2 expression of immune cells in the saliva of SLE. Materials and methods: This cross-sectional study conducted at the the SLE patients who met the inclusion and exclusion criteria. Those who had signed informed consent involved to underwent unstimulated saliva collection and blood samples for TLR2 and vitami

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Zelzer, Sieglinde, Andreas Meinitzer, Markus Herrmann, Walter Goessler, and Dietmar Enko. "A Novel Method for the Determination of Vitamin D Metabolites Assessed at the Blood-Cerebrospinal Fluid Barrier." Biomolecules 11, no. 9 (2021): 1288. http://dx.doi.org/10.3390/biom11091288.

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The brain’s supply with vitamin D is poorly understood. Therefore, the present study aimed to determine 25-hydroxy vitamin D3 (25(OH)D) and 24,25-dihydroxy vitamin D (24,25(OH)2D3) in serum and cerebrospinal fluid (CSF) from individuals with intact and disturbed brain-CSF-barrier (BCB) function. In 292 pairs of serum and CSF samples the vitamin D metabolites were measured with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). CSF/serum ratios (QALB, Q25(OH)D, Q24,25(OH)2D3) were calculated. Median (IQR) serum concentrations of 25(OH)D and 24,25(OH)2D3 were 63.8 (43.4–83.9)

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Perumal, Nandita, Abdullah Al Mahmud, Abdullah H. Baqui, and Daniel E. Roth. "Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh." Public Health Nutrition 20, no. 10 (2015): 1865–73. http://dx.doi.org/10.1017/s1368980015003092.

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AbstractObjectiveTo determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine.DesignA prospective observational follow-up of a randomized trial.SettingMaternal–child health facility in Dhaka, Bangladesh (23°N).SubjectsInfants born to pregnant women (n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D

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