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Relevant bibliographies by topics / Olfactory Ectomesenchymal Stem Cell / Dissertations / Theses

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Dissertations / Theses on the topic 'Olfactory Ectomesenchymal Stem Cell'

Author: Grafiati

Published: 11 March 2023

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1

Ould-Yahoui, Adlane. "Le système MMP/TIMP dans la croissance neuritique et la motilité des cellules souches de la muqueuse olfactive." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20672.

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Les métalloproteases matricielles (MMPs) appartiennent à une famille d'endopéptidases dépendantes du zinc, présentent sous forme secrétée ou membranaire (MT-MMP) et qui jouent un rôle fondamental dans la signalisation cellulaire. L'activité des MMPs est régulée par leur inhibiteurs endogènes, les inhibiteurs tissulaires des MMPs (TIMPs). Le système MMP/TIMP régule les interactions cellule-cellule et cellule-matrice extra cellulaire et module la motilité cellulaire par clivage protéolytique des composants de la matrice extra cellulaire aussi bien lors de processus physiologiques que dans des si

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2

Patel, Nirmal Praful School of Medicine UNSW. "Olfactory progenitor cell transplantation into the mammalian inner ear." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/26180.

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A practical consideration in the development of cellular therapy technology for the inner ear is the development of an in vitro model for assessing the optimal conditions for successful application of cells. The first part of this thesis describes the adaptation of the cochleovestibular structure harvested from P1 mouse pups for analysis of factors critical for the optimal implantation of stem cells in the inner ear. Results of these studies establish that the c17.2 neural stem cell line can be introduced into the cochleovestibular structure in vitro. Using this model, c17.2 cells demonstrated

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3

Reiter, Allison R. "Role of dietary zinc deficiency in adult neuronal stem cell proliferation in the olfactory bulb." Tallahassee, Fla. : Florida State University, 2008. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/341805.

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Thesis (Honors paper)--Florida State University, 2008.<br>Advisor: Cathy W. Levenson, PhD., Florida State University, College of Human Sciences, Dept. of Nutrition, Food and Exercise Sciences. Includes bibliographical references.

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4

Caremoli, F. "PURIFICATION, CHARACTERIZATION AND CULTURE OF ENSHEATHING CELLS FROM HUMAN OLFACTORY MUCOSA BIOPSIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/335140.

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Among all the possible sources of mesenchymal stem cells, adipose tissue and olfactory mucosa have raised great interest and have become some of the most investigated sources. Adipose tissue-derived mesenchymal stem cells and the fat itself as a source of human adipose derived stem cells, represent one of the major fields of research in regenerative medicine. A great advantage is represented by the minimal invasive and high accessibility to adipose tissue and its ready availability. In the present study, hADSCs were isolated from the adipose tissue donated by several patient and have been in

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5

Momma, Stefan. "Neural stem cells and their contribution to neurogenesis in the adult mammalian brain /." Stockholm : Karolinska institutet, 2002. http://diss.kib.ki.se/2002/91-7349-324-4/.

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6

Oliver, Joe, Cuihong Phd Jia, and Theodoor Phd Hagg. "Inhibition of focal adhesion kinase promotes adult olfactory stem cell self-renewal and neuroregeneration via ciliary neurotrophic factor." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/97.

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The Olfactory Epithelium (OE) is a specialized epithelial tissue inside the nasal cavity that is involved in the smell sensation. The OE maintains neuroregeneration, i.e. producing new olfactory sensory neurons, throughout the adult life via neural stem cell self-renewal, proliferation, neuronal differentiation and maturation. The neural stem cell niche regulates stem cell self-renewal and proliferation, and consists of stem cells, blood vessels and multiple extracellular matrix proteins (ECMs). ECMs regulate stem cell adhesion, proliferation, differentiation and migration via integrins. One o

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7

Hawkins, Sara Joy. "The timing of regeneration in the amphibian olfactory system." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15444.

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Mestrado em Biologia Molecular e Celular<br>Comprehending the mechanisms that make lifelong neurogenesis possible has a clear interest for the better understanding of the basic principles that govern cellular and molecular interactions in the nervous system, as well as a relevant clinical interest. The limited ability of the central nervous system to generate new neurons in order to replace those that have been lost is a formidable obstacle to recovery from neuronal damage caused by injury or neurodegenerative disease. The olfactory system (OS) is an ideal system to study the process of neuron

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8

Bianco, John I. "Stem Cells and Ensheathing Cells from the Nasal Olfactory Mucosa: a Tool for the Repair of the Damaged Spinal Cord." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/368098.

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The olfactory mucosa has been shown to be a site where continual regeneration takes place throughout adulthood, making this system relatively unique with great potential in respect to autologous cell graft therapies. The olfactory mucosa is readily accessible with no deleterious effects on olfaction if biopsied. The presence of olfactory ensheathing cells (OECs), as well as a stem cell to facilitate the regeneration of this tissue, has been previously described. The first aim of this study was to further characterise olfactory ensheathing cells in rat and human and to gain some insights into t

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9

Orechio, Dailiany. "Caracterização morfológica e celular da zona subventricular e da corrente rostral migratória em encéfalos de fetos caninos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-29092016-112302/.

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Precursores neurais originados na zona subventricular (ZSV) de algumas espécies animais possuem uma rota de migração neuronal destinada ao bulbo olfatório principal (BOP), onde os neuroblastos migrantes se diferenciam em interneurônios. Esta corrente migratória é mantida na idade adulta. A compreensão de como se organiza na idade fetal é essencial para a compreensão geral e estabelecimento de novas terapias celulares. O objetivo deste estudo é caracterizar a composição celular e organização morfológica da ZSV e da corrente rostral migratória (CRM) em encéfalos de fetos caninos. A ZSV, CRM e BO

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10

Malik, Astha. "Circadian Clocks in Neural Stem Cells and their Modulation of Adult Neurogenesis, Fate Commitment, and Cell Death." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1434986257.

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11

Rodrigues, Marcio Nogueira. "Avaliação do transplante de células tronco do epitélio olfatório de ratos em coelhos da raça Nova Zelândia submetidos a trauma medular." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-15032012-085251/.

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As células-tronco do epitélio olfatório possuem a capacidade de diferenciação, regeneração de neurônios olfatórios e atuam no processo de mielinização das fibras nervosas. O objetivo desse trabalho foi verificar o potencial terapêutico de células-tronco do epitélio olfatório de ratos Wistar em terapia celular em coelhos submetidos à lesão medular. Foram utilizados ratos com idade de 2 meses e coelhos da raça nova Zelândia obtidos no Biotério do Departamento de Patologia da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os fragmentos do epitélio olfatório dos ratos

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12

De, las Heras Rachel, and n/a. "Neuronal Differentiation: A Study Into Differential Gene Expression." Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040225.161725.

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Neuronal differentiation encompasses an elaborate developmental program which until recently was difficult to study in vitro. The advent of several cell lines able to differentiate in culture proved to be the turning point for gaining an understanding of molecular neuroscience. In particular the olfactory epithelium provides an attractive tool with which to investigate fundamental questions relating to neuronal differentiation, as it displays a unique capacity to regenerate and to retain a neurogenetic potential from its genesis and throughout adult life. The coordinated regulation of gene exp

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13

De, las Heras Rachel. "Neuronal Differentiation: A Study Into Differential Gene Expression." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367735.

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Neuronal differentiation encompasses an elaborate developmental program which until recently was difficult to study in vitro. The advent of several cell lines able to differentiate in culture proved to be the turning point for gaining an understanding of molecular neuroscience. In particular the olfactory epithelium provides an attractive tool with which to investigate fundamental questions relating to neuronal differentiation, as it displays a unique capacity to regenerate and to retain a neurogenetic potential from its genesis and throughout adult life. The coordinated regulation of gene exp

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14

Honoré, Axel. "Effet des Cellules Gliales Olfactives issues des Bulbes Olfactifs sur les cellules souches épendymaires et leur progénie après une lésion médullaire." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR060/document.

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Les lésions médullaires traumatiques (LMT) conduisent à une atteinte des voies nerveuses sensitives et motrices. Leur taux de mortalité reste très élevé, d'où la nécessité de trouver de nouveaux traitements. Les Cellules Gliales Olfactives (CGOs) représentent un candidat intéressant de par leur fonction au sein du système olfactif primaire. La découverte d'une population de cellule souche neurale bordant le canal central de la moelle spinale (MS) adulte, appelées cellules épendymaires, suscite un nouvel espoir dans le domaine des biothérapies. Ce travail de thèse a permis d'étudier l'effet d'u

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15

Boone, Nathalie. "Les cellules souches olfactives humaines : un nouveau modèle d'étude des mécanismes à l'origine d'une maladie neurodégénérative, la dysautonomie familiale." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20694.

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La dysautonomie familiale (FD) est une neuropathie héréditaire provoquée par des mutations au sein du gène IKBKAP, la plus commune d'entre elles induisant un épissage alternatif de l'exon 20 au sein de du pré-ARNm de façon tissu-spécifique. L'épissage aberrant est particulièrement prononcé dans les tissus nerveux, conduisant à la dégénerescence progressive des neurones sensoriels et autonomes. La spécificité de la perte des cellules nerveuses dans la FD est mal comprise, par manque d'un modèle approprié. Afin de mieux comprendre les mécanismes moléculaires de l'épissage des ARNm d'IKBKAP, nous

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16

Chalfouh, Chaima. "Effet de la stimulation magnétique répétitive trans-spinale comme thérapie non invasive dans le cadre des lésions médullaires. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury Resident neural stem cells guarantee the regeneration promoted by bulbar olfactory ensheathing cell transplantation after spinal cord injury." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR099.

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Les lésions de la moelle spinale constituent un problème de santé public d’une ampleur grandissante. Bien que l’espérance de vie ait été améliorée, les patients médullo-lésés souffrent de certains handicaps entraînant une perte partielle ou complète des fonctions sensorielles et/ou motrices. La moelle spinale lésée entreprend aussitôt une réponse à cette lésion. Chronologiquement, la lésion se divise en deux grandes phases : la phase primaire qui se caractérise par la destruction tissulaire induite par le traumatisme mécanique, suivie d’une destruction cellulaire. Alors que la phase secondaire

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17

Girard, Stephane. "Amnésie et thérapie cellulaire : Etude de l'écotropisme des cellules souches adultes de la lamina propria olfactive." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4759.

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Les faibles capacités régénératives intrinsèques du système nerveux central, après la survenue de lésions traumatiques ou l'apparition de maladies neuro-dégénératives, ont orienté les recherches vers des thérapies basées sur l'utilisation de cellules souches dans le but de régénérer le tissu cérébral. Cependant, des limitations éthiques et techniques associées aux cellules souches embryonnaires, fœtales ou neurales chez l'adulte restreignent leur utilisation en clinique humaine. À la recherche d'une source alternative, nous nous sommes intéressés à des cellules souches adultes peu connues, pro

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18

Di, Trapani Mariano. "Comparative study of immune regulatory properties of stem cells derived from different tissues." Doctoral thesis, 2015. http://hdl.handle.net/11562/910783.

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La terapia mediante l’uso di cellule staminali allogeniche è una potenziale alternativa per la cura di malattie infiammatorie e degenerative. Vari gruppi di ricerca hanno messo in luce le proprietà immunomodulatorie di varie cellule staminali, come per esempio le cellule mesenchimali stromali, ma al momento non è stato ancora fatto uno studio comparativo mostrante differenze qualitative e quantitative delle proprietà immunoregolatorie di staminali di diversa origine. Lo scopo del lavoro è stato quindi quello di confrontare le proprietà immunologiche di varie cellule staminali, tra cui cellule

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19

Carter, Lindsay A. "Olfactory epithelial horizonal basal cells : an assessment of stem cell candidacy and behavioural regulation in vivo and in vitro." Thesis, 2002. http://hdl.handle.net/2429/12405.

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In the olfactory epithelium (OE), new olfactory receptor neurons (ORNS) are continually generated throughout mammalian adulthood. Given this substantial neuronal turnover, a stem cell is proposed to reside within the basal compartment of the OE, which generates ORNs on demand when stimulated by changes in its microenvironment. Although previous studies have identified possible candidates for the olfactory stem cell, its exact identity is as yet unknown. We hypothesize that a population o f horizontal basal cells (HBCs), situated upon the basement membrane of the OE, contains stem cells t

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20

Li, Ming-Yang, and 李明洋. "YAP Mediates TRIP6-Promoted Neural Stem Cell Maintenance in the Postnatal Mammalian Subventricular Zone-Olfactory Pathway and Its Applications." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/sgy63g.

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博士<br>國立臺灣師範大學<br>生命科學系<br>107<br>Postnatal neurogenesis in the dentate gyrus and subventricular zone (SVZ)-olfactory bulb pathway in mammals is regulated by extrinsic and intrinsic factors. Since endogenous neural stem cells (NSCs) in the adult brain have potential to treat neurodegenerative disorders, studying mechanisms regulating postnatal NSCs may provide clinical applications. However, the role of TRIP6, YAP and ginkgolide B in postnatal NSCs remain unclear. TRIP6 belongs to zyxin family of LIM proteins, which have been shown to interact with various proteins to regulate cell proliferati

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21

Bouab, Meriem. "L’effet du vieillissement sur les cellules souches neurales adultes." Thèse, 2010. http://hdl.handle.net/1866/4222.

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La neurogenèse persiste à l’âge adulte dans deux régions du système nerveux central (SNC) des mammifères : la zone sous-ventriculaire (SVZ) du cerveau antérieur et la zone sous-granulaire (SGZ) de l’hippocampe. Cette neurogenèse est possible grâce à la capacité de prolifération des cellules souches présentes dans les niches de la SVZ et la SGZ, mais en vieillissant, le cerveau subit une diminution dramatique du nombre de cellules souches neurales adultes (CSNa), une diminution de la prolifération cellulaire et une altération des niches de neurogenèse. Cependant, une importante question reste s

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