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Relevant bibliographies by topics / Olfactory mucosa / Dissertations / Theses

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Dissertations / Theses on the topic 'Olfactory mucosa'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Sacramento, Sónia Raquel Capela. "Establishing model systems from olfactory mucosa stem cells." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11806.

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Mestrado em Biomedicina Molecular<br>As células estaminais são uma classe distinta de células, devido às suas capacidades de regeneração e diferenciação em vários tipos de células especializadas. Os nichos onde estas se encontram servem-lhes de sustentação e permitem a sua manutenção num estado indiferenciado, afectando a sua regeneração e diferenciação através de estímulos. As células estaminais dividem-se em duas classes: embrionárias (pluripotentes) e adultas (multipotentes), embora também existam células estaminais pluripotentes induzidas. Nos últimos anos tem-se estudado a possibilidade

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2

Burman, Dawn Marie. "Alachlor-induced oxidative stress in rat olfactory mucosa." Cincinnati, Ohio : University of Cincinnati, 2001. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1006204005.

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3

Clark, Stephen. "Aging in the mammalian olfactory system /." View online, 2009. http://repository.eiu.edu/theses/docs/32211131566906.pdf.

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4

Che, Harun Fauzan Khairi. "Mimicking the human olfactory system : a portable e-mucosa." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3130/.

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The study of electronic noses has been an active area of research for over 25 years. Commercial instruments have been successfully deployed within niche application areas, for example, the food, beverage and pharmaceutical industries. However, these instruments are still inferior to their human counterparts and have not achieved mainstream success. Humans can distinguish and identify many thousands of different aromas, even at very low concentration levels, with relative ease. The human olfactory system is extremely sophisticated, which allows it to out-perform artificial instruments. Though

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5

STRAPPAVECCIA, Silvia. "IMPIANTO AUTOLOGO DI CELLULE STAMINALI NOM (NASAL OLFACTORY MUCOSA) IN CANI PARAPLEGICI CRONICI [AUTOLOGOUS IMPLANT OF NASAL OLFACTORY MUCOSA (NOM) STEM CELLS IN CHRONIC PARAPLEGIC DOGS]." Doctoral thesis, Università degli Studi di Camerino, 2007. http://hdl.handle.net/11581/401897.

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La terapia delle lesioni spinali croniche dell'uomo rappresenta attualmente uno dei maggiori campi di interesse della ricerca scientifica. Tra le strategie sperimentali di ultima elaborazione, il trapianto di cellule staminali sta dimostrando notevoli potenzialita' per la cura di molte patologie del SNC. I modelli animali principalmente utilizzati per gli studi sperimentali sono i ratti, ma le dimensioni del midollo spinale in questa specie sono estremamente diverse da quelle dell'uomo, e le condizioni di laboratorio in cui i protocolli sperimentali vengono applicati sono molto differenti dal

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6

McCurdy, Richard D., and n/a. "Investigations of Olfactory Mucosa to Test the Neurodevelopmental Nature of Psychoses." Griffith University. School of Biomolecular and Biomedical Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20051121.133824.

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Evidence from various sources suggests that schizophrenia may result from altered brain development. The adult olfactory epithelium provides an available 'window' on neuronal development because new neurons are formed there throughout life. This thesis set out to test the neurodevelopmental hypothesis of psychotic disease. Two cell-based models, skin fibroblast and olfactory mucosa culture, were employed to investigate this hypothesis. In order to first demonstrate the utility of olfactory mucosa culture as a model of neurodevelopment, and to allow the candidate to gain proficiency in the cult

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McCurdy, Richard D. "Investigations of Olfactory Mucosa to Test the Neurodevelopmental Nature of Psychoses." Thesis, Griffith University, 2005. http://hdl.handle.net/10072/366460.

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Evidence from various sources suggests that schizophrenia may result from altered brain development. The adult olfactory epithelium provides an available 'window' on neuronal development because new neurons are formed there throughout life. This thesis set out to test the neurodevelopmental hypothesis of psychotic disease. Two cell-based models, skin fibroblast and olfactory mucosa culture, were employed to investigate this hypothesis. In order to first demonstrate the utility of olfactory mucosa culture as a model of neurodevelopment, and to allow the candidate to gain proficiency in the cult

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8

Franzen, Anna. "Tissue-selective activation and toxicity of substituted dichlorobenzenes : studies on the mechanism of cell death in the olfactory mucosa /." Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6161.

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9

Caremoli, F. "PURIFICATION, CHARACTERIZATION AND CULTURE OF ENSHEATHING CELLS FROM HUMAN OLFACTORY MUCOSA BIOPSIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/335140.

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Among all the possible sources of mesenchymal stem cells, adipose tissue and olfactory mucosa have raised great interest and have become some of the most investigated sources. Adipose tissue-derived mesenchymal stem cells and the fat itself as a source of human adipose derived stem cells, represent one of the major fields of research in regenerative medicine. A great advantage is represented by the minimal invasive and high accessibility to adipose tissue and its ready availability. In the present study, hADSCs were isolated from the adipose tissue donated by several patient and have been in

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10

Eriksson, Catarina. "Herbicide-induced toxicity in the nasal olfactory mucosa : studies on dichlobenil and chlorthiamid /." Uppsala : Sveriges lantbruksuniv, 1995. http://epsilon.slu.se/avh/1995/91-576-4881-6.gif.

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11

Todorovic, Michael. "Assessing the Role of the Oxidative Stress Response ‘Master Regulator’ Nrf2 in Parkinson’s Disease." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367349.

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Parkinson’s disease (PD) is a complex neurodegenerative disorder influenced by a combination of genetic and environmental factors. The molecular mechanisms that underlie PD are unknown. However, oxidative stress and impairment of antioxidant defence mechanisms have been implicated as major contributors to disease pathogenesis. Previously, we have reported a PD patient-derived cellular model, generated from biopsies of the olfactory mucosa, termed hONS cells. These cells have demonstrated disease-specific differences in gene expression and metabolic activity associated with the Nrf2-mediated an

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12

Bergman, Ulrika. "Transfer and toxicity of some drugs and chemicals in the olfactory mucosa and bulb /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5909-5.pdf.

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13

Ng, Khuen Yen Prince of Wales Medical Research Institute Faculty of Medicine UNSW. "Isoprenoids in Parkinson's disease." Awarded by:University of New South Wales. Prince of Wales Medical Research Institute, 2009. http://handle.unsw.edu.au/1959.4/44827.

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Parkinson???s disease (PD) is a progressive neurodegenerative disease characterised pathologically by the selective death of the dopaminergic neurons of the substantia nigra and the appearance of abnormal inclusions in some surviving neurons. A body of evidence from epidemiological, in vitro and in vivo studies suggest that isoprenoids, a lipid family which includes cholesterol, dolichol and ubiquinone, may play a role in PD, although to date the data has been conflicting with little consensus regarding the type or direction of change in isoprenoids in PD. The current study investigated isopr

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14

Espefält, Westin Ulrika. "Olfactory Transfer of Analgesic Drugs After Nasal Administration." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7829.

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Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. Evidence for the olfactory transfer of drugs from the nasal cavity to the CNS after nasal administration, bypassing the BBB, is available for both animals and humans. The aims of this thesis were to study the olfactory transfer of morphine to the CNS after nasal administration, and to compa

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15

Trinh, Kien Ai. "The role of adenylyl cyclase type III in odorant perception /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5023.

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16

Rehorek, Susan Joyce. "A potential role of the Squamate Harderian gland in vomerolfaction /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phr3451.pdf.

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17

Hörnberg, Maria. "Effects of retinoic acid in the mouse olfactory sensory systems /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371.

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18

Franzén, Anna. "Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6161.

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<p>The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. In this thesis, mechanisms involved in tissue-selective toxicity in the olfactory mucosa of rodents have been investigated using the olfactory toxicant 2,6-dichlorophenyl methylsulphone (2,6-diClPh-MeSO<sub>2</sub>) as a model compound. Comparative studies were performed with the non-toxic 2,5-dichlorophenyl methylsulphone (2,5-diClPh-MeSO<sub>2</sub>) and the reasons for the strikingly different t

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19

Bianco, John I. "Stem Cells and Ensheathing Cells from the Nasal Olfactory Mucosa: a Tool for the Repair of the Damaged Spinal Cord." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/368098.

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The olfactory mucosa has been shown to be a site where continual regeneration takes place throughout adulthood, making this system relatively unique with great potential in respect to autologous cell graft therapies. The olfactory mucosa is readily accessible with no deleterious effects on olfaction if biopsied. The presence of olfactory ensheathing cells (OECs), as well as a stem cell to facilitate the regeneration of this tissue, has been previously described. The first aim of this study was to further characterise olfactory ensheathing cells in rat and human and to gain some insights into t

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20

Godoy, Maria Dantas Costa Lima. "Acometimento do epitélio olfatório pela doença de Alzheimer: um estudo de correlação clínico-patológica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-05102015-122610/.

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A doença de Alzheimer (DA) é caracterizada por declínio cognitivo e funcional progressivo e constitui-se como a forma mais prevalente de demência. O diagnóstico da DA é realizado atualmente, exclusivamente por meio de critérios clínicos. No entanto, a manifestação clínica da DA é precedida por um longo período assintomático, com depósito silencioso das proteínas tau e -amiloide no tecido cerebral. Evidências recentes demonstram que a mucosa olfatória, estrutura periférica e facilmente acessível também está acometida na DA, podendo representar um bom método de diagnóstico preciso e precoce dest

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21

Cardillo, Giancarlo de Mattos. "Comprimento telomérico no sistema nervoso central de um modelo de doença de Alzheimer tratado com lítio." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-05062018-112209/.

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Telômeros são complexos DNA-proteína presentes nas extremidades dos cromossomos. Os telômeros se encurtam a cada divisão celular, sendo o comprimento telomérico, portanto, considerado um biomarcador do envelhecimento celular. Esse encurtamento é vinculado a diversas doenças relacionadas à idade avançada. Na doença de Alzheimer (DA), têm sido associados com diversas vias fisiopatológicas, como a neuroinflamação e o estresse oxidativo, porém seus mecanismos ainda são pouco conhecidos. A maioria dos estudos sobre comprimento telomérico na DA é realizada em DNA leucocitário, pouco se sabendo sobre

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22

Pinna, Fabio de Rezende. "Distribuição do neuroepitélio olfatório em concha média e superior em cadáveres humanos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-19112008-162629/.

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INTRODUÇÃO: A biópsia do neuroepitélio olfatório (NeuO) oferece perspectivas para aplicações terapêuticas tanto em doenças do olfato como doenças neurodegenerativas. Uma coleta bem sucedida desse tecido in vivo ainda não é rotina, devido á carência de estudos sobre a distribuição do NeuO em conchas superior (CS) e média (CM). Neste trabalho, descrevemos a distribuição do NeuO na CS e CM em cadáveres a partir da retirada integral dessas estruturas e posterior análise histológica por coloração de hematoxilina e eosina (HE) e imunoistoquímica. Além disso, também analisamos a influência do sexo, i

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23

Andrews, P. J. "A prospective, controlled study on 131 patients assessing patient safety and nasal function outcomes following human olfactory mucosa biopsy as a source of cells for central nervous system regeneration during Endoscopic Sinus Surgery." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1530783/.

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Hypotheses: The primary hypothesis states; olfactory harvesting is a safe procedure and does not incur a reduction in nasal function including the sense of smell when compared to a control group. The secondary hypothesis states; ESS improves olfactory outcome in CRS patients with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Materials and Methods: Full Ethical and Research and Development (R&D) approval was granted; Ref: 05/Q0512/103. 131 patients were recruited over a 2 year period and non-randomised into the olfactory biopsy and control arms. Statistical significance was accep

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24

Carlsson, Carina. "Neurotoxic Effects of Dichlorophenyl Methylsulphones Related to Olfactory Mucosal Lesions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3463.

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25

Al, Bakri Wisam Saad Hasan. "Characterization of atrazine transport across nasal respiratory and olfactory mucosae." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4559.

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The herbicide atrazine is one of the most commonly used pesticides in United States. Atrazine was banned in the European Union in 2005 because of its ubiquity in drinking water; however, in The United States more than 75 million pounds of atrazine are used annually, especially in the Midwest. Atrazine has many adverse health effects including enhancing developmental, immunologic endocrine alterations. Studies have reported that exposure to atrazine causes dopaminergic toxicity and mitochondrial dysfunction; these cellular changes have been linked to an increase in the incidence of Parkinson's

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26

Jansson, Björn. "Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905.

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<p>The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer.</p><p>In a mouse model, [<sup>3</sup>H]-dopamine was given as a unilateral nasal dose. The resulting radioactivity in the ipsilateral olfactory bulb was significantly higher than that in the contralateral bulb and peaked at 4 h. Tape section autoradiogra

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27

Gueye, Yatma. "Implication de MMP-2 dans les propriétés des cellules engainantes de la muqueuse olfactive et dans la réparation des lésions de la moelle épinière : études in vitro et in vivo." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20681.

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Lorsque le système nerveux central des mammifères est lésé, un ensemble de réactions secondaires impliquant l’inflammation et une gliose réactive conduit à la formation d’une cicatrice gliale qui inhibe la régénération axonale. Dans le cas d’une lésion de la moelle épinière l’absence de réparation efficace des réseaux axonaux lésés peut conduire à la paraplégie ou à la tétraplégie. Aujourd’hui on estime à plus de 2,5 millions le nombre d’individus dans le monde souffrant de ces handicaps et il n’existe à ce jour aucun traitement validé pour améliorer la situation des patients. Cependant, certa

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28

Granger, Nicolas. "Effects of intraspinal transplantation of mucosal olfactory ensheathing cells in chronic spinal cord injury in domestic dogs." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608161.

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29

Yamamoto, Mie. "Transplanted olfactory mucosal cells restore paw reaching function without regeneration of severed corticospinal tract fibres across the lesion." Kyoto University, 2010. http://hdl.handle.net/2433/120554.

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30

Rehorek, Susan Joyce. "A potential role of the Squamate Harderian gland in vomerolfaction / by Susan Joyce Rehorek." Thesis, 1997. http://hdl.handle.net/2440/18997.

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Copies of author's previously published articles inserted.<br>Bibliography: leaves 89-123.<br>iv, 123, [21] leaves, [21] plates : col. ill. ; 30 cm.<br>The aims of this study are to morphologically examine the structure of the Hardorian gland within major squamate clades and to infer its potential role as a source of secretion for the squamate VNO. The thesis identifies some evolutionary trends in Harderian gland, olfactory mucosae and VNO structure across a range of taxa. Representative species exhibiting olfactory (Gekkota) or vomerolfactory (Serpentes) specialisation and generalised nasal c

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31

Alvites, Rui Damazio. "Combined use of Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials in Regenerative Therapies after Peripheral Nerve Injury." Doctoral thesis, 2021. https://hdl.handle.net/10216/134928.

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32

Alvites, Rui Damazio. "Combined use of Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials in Regenerative Therapies after Peripheral Nerve Injury." Tese, 2021. https://hdl.handle.net/10216/134928.

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33

Naidoo, Bashan. "Towards the development of an electronic nose." Thesis, 2003. http://hdl.handle.net/10413/4261.

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Electronic noses are targeted at determining odour character in a fashion that emulates conscious odour perception in mammals. The intention of this study was to develop an organisational framework for electronic noses and deploy a sample cheese odour discriminator within this framework. Biological olfactory systems are reviewed with the purpose of extracting the organisational principles that result in successful olfaction. Principles of gas handling, chemoreception, and neural processing are considered in the formulation of an organisational framework. An electronic nose is then developed in

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34

Cheng, Chu-Hsun, and 鄭楚勳. "Investigation of combination of high dose chondroitinase ABC and olfactory mucosa progenitor cells on the repair of spinal cord injury." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/369td6.

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博士<br>國立陽明大學<br>藥理學研究所<br>104<br>Spinal cord injury (SCI) often results in neuronal death and demyelination. During the healing process, large amount of glial scar formed at the lesion site is one of the major barriers to axonal regeneration. The main constituent of glial scar is chondroitin sulfate proteoglycans (CSPGs) that produced by activated astrocyte. Treatment of chondroitinase ABC (ChABC) has been reported to remove CSPGs glycosaminoglycan (GAG) side chains and enhance axonal regeneration. Cell transplantation therapies for spinal cord injury contributes to restoration of neuronal fun

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35

Batista, Pedro Afonso Fernandes. "Transplante de células olfativas (olfactory ensheating cells). Mudança de paradigma no tratamento de lesões medulares?" Master's thesis, 2018. http://hdl.handle.net/10451/42449.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2018<br>As lesões traumáticas da medula espinhal são atualmente um problema de saúde importante, nomeadamente por afetar muitos indivíduos durante a sua vida ativa, condicionando uma redução drástica da sua qualidade de vida. Quando ocorre uma lesão medular, há uma diminuição da transmissão do sinal elétrico através das vias medulares ascendentes e descentes, devido a uma interrupção física dos feixes neuronais, mas também devido ao microambiente que se forma no local de lesão, altamente i

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