Log in

Relevant bibliographies by topics / Oligonucleotide Oligonucleotide / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Oligonucleotide Oligonucleotide.

Dissertations / Theses on the topic 'Oligonucleotide Oligonucleotide'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Oligonucleotide Oligonucleotide.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Scotson, James L. "Understanding oligonucleotide synthesis." Thesis, University of Huddersfield, 2016. http://eprints.hud.ac.uk/id/eprint/32090/.

Full text

Abstract:

Oligonucleotides are synthesised almost exclusively via the solid-supported phosphoramidite method. However popular this method may be, the expensive reagents used in large excess during the synthesis as well as the large amounts of organic and aqueous solvents and purification steps makes the scale-up of oligonucleotide synthesis costly and possibly harmful to the environment. The therapeutic use of anti-sense oligonucleotides (ASOs) is hindered by their susceptibility to nuclease catalysed hydrolysis and to overcome this problem ASOs have been modified commonly by the introduction of a phosp

APA, Harvard, Vancouver, ISO, and other styles

2

Barnekow, Frank. "Darstellung einzelsträngiger DNA-Polymeraseprodukte über eine kovalente Membrananbindung und deren enzymatische Umsetzungen." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=957430485.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Bauer, Oliver. "Technology development for oligonucleotide fingerprinting applying multiplexed PNA hybridizations and MALDI-TOF mass spectrometry detection /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/326/index.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Torres, Adrian Gabriel. "MicroRNA targeting with oligonucleotide analogues." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610040.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Steck, Anna-Lena [Verfasser]. "Oligonucleotide-modified Nuclotides / Anna-Lena Steck." Konstanz : Bibliothek der Universität Konstanz, 2013. http://d-nb.info/1058325981/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Luchi, Daniela de. "Crystallographic study on oligonucleotide coiled-coils." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/6457.

Full text

Abstract:

En la presente tesis doctoral se han realizado estudios estructurales de DNA. Estudios previos han demostrado que los coiled-coils de d(ATATATATATAT) y d(ATATATATAT) tienen unos parámetros geométricos muy diferentes. El objetivo de esta tesis es aclarar las propiedades de los coiled-coils.<br/>Con esta finalidad se han estudiado por cristalografía de Rayos X oligonucleótidos con diferentes secuencias y con extremos cohesivos que fijen la geometría de los coiled-coils. Se han utilizado oligonucleótidos con la secuencia d(CG)n(AT)m o (AT)m(CG)n y otros semejantes. En la mayor parte de ellos n=1

APA, Harvard, Vancouver, ISO, and other styles

7

Pritchard, Clare Elizabeth. "Studies in solid supported oligonucleotide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/11282.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Wolfe, Justin Mahoney. "Peptide conjugation to enhance oligonucleotide delivery." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118278.

Full text

Abstract:

Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The intracellular delivery of functional macromolecules remains an outstanding challenge in biomedicine. While small molecules can diffuse through the plasma membrane, many large therapeutic molecules are not internalized to an appreciable extent. One strategy to improve cell uptake involves linking the molecule of interest to a cell-penetrating peptide (CPP). CPPs are widely employed to enhance macromo

APA, Harvard, Vancouver, ISO, and other styles

9

Razumovitch, Julia. "Hybridization of surface-tethered oligonucleotide brushes /." [S.l.] : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8744.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Douglas, Andrew Graham Lim. "Oligonucleotide-based therapies for neuromuscular disease." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:d14706a3-c436-46ff-87c4-40bbbad6dc01.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Brandsch, Thomas. "Untersuchungen zur Selbstreplikation von Oligonucleotiden an Oberflächen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969698585.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Schöneborn, Holger. "Selbstreplizierende Oligonucleotide zum Einfluss der Matrizenlänge bei kinetischen Untersuchungen auf der Basis des Fluoreszenz-Resonanz-Energie-Transfers /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964541297.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Siegert, Carsten. "Chemische und enzymatische Synthese modifizierter Nukleinsäuren für die Analytik mit Hilfe der MALDI-TOF-Massenspektrometrie." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=958300763.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Feyerabend, Sven. "Darstellung von Konjugaten aus hexahistidinmodifizierter bakterieller alkalischer Phosphatase und NTA-funktionalisierten Oligonukleotiden." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=957586213.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Hausch, Felix. "Multifunktionale Nukleinsäure-Konjugate zur Selektion von katalytischen Oligonukleotiden." [S.l. : s.n.], 2000. http://www.diss.fu-berlin.de/2000/75/index.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Hohlfeld, Andreas. "[Alpha]-Hydroxy-2-nitrobenzylphosphonat-modifizierte [Alpha-Hydroxy-2-nitrobenzylphosphonat-modifizierte] Oligonucleotide Synthese, Eigenschaften und neue Synthesekonzepte /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974524123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Schliepe, Jürgen. "Synthese von metallmodifizierten Oligonucleotiden mit genregulatorischen Eigenschaften." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=966515021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gräsl, Sonja. "Synthese C8-Arylamin-modifizierter 2'-Desoxyguanosinderivate und deren Einbau in Oligonucleotide." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974451452.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Engstrom, Julia U. "Mammalian cell cycle regulates oligonucleotide-mediated repair." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 219 p, 2008. http://proquest.umi.com/pqdweb?did=1481658501&sid=9&Fmt=2&clientId=8331&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

May, Jonathan Paul. "Development of oligonucleotide probes for genetic analysis." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269932.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Lin, Zhaoru. "Characterisation of antisense oligonucleotide-stimulated ribosomal frameshifting." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609380.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Reshat, Reshat. "Evaluating the genotoxic potential of oligonucleotide pharmaceuticals." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10928.

Full text

Abstract:

According to regulatory guidelines, routine genotoxicity tests are not appropriate for biotechnology derived pharmaceuticals, including oligonucleotide based therapeutics, as they are not expected to interact with genomic DNA. However, reports of oligonucleotides capable of binding duplex DNA in a sequence specific manner to form triple-helix (triplex) or displacement-loop (D-loop) structures that in turn cause mutation have raised concern. The European Medicines Agency (EMA) has questioned the capability of antisense oligonucleotide (ASO) therapeutics to form such structures at genomic DNA. A

APA, Harvard, Vancouver, ISO, and other styles

23

Campàs, i. Homs Mònica. "Functional oligonucleotide recognition nanomodules for electrochemical DNA biosensors." Doctoral thesis, Universitat Rovira i Virgili, 2002. http://hdl.handle.net/10803/8509.

Full text

Abstract:

The goal of this thesis has been to design, characterise and optimise an electrochemical DNA sensor array. In order to investigate the oligonucleotide probe immobilisation and the hybridisation detection, preliminary experiments with an easy system were performed. This system demonstrated the suitability of oligonucleotide self-assembled monolayers (SAMs) on gold surfaces as immobilisation method. Due to the rapid DNA sensor development towards DNA arrays, a modified strategy was proposed. This strategy was based on the site-directed electrodeposition of biorecognition nanomodules on electrode

APA, Harvard, Vancouver, ISO, and other styles

24

Disterer, Petra. "Oligonucleotide-mediated gene editing of Apolipoprotein A-I." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444267/.

Full text

Abstract:

Apolipoprotein A-I (ApoA-I) is the major protein constituent of high density lipoprotein (HDL) and controls reverse cholesterol transport, an important process in preventing atherosclerosis. A natural point mutation, ApoA-lMiiano (ApoA-Im) enhances the atheroprotective potential of HDL. Here, I attempt to introduce this specific modification into the genome of mammalian cells using the gene therapy strategy of oligonucleotide-mediated gene editing. I showed successful APOA-I gene editing in recombinant Chinese hamster ovary (CHO-AI) and human hepatocellular carcinoma (HepG2) cells by polymeras

APA, Harvard, Vancouver, ISO, and other styles

25

Arteaga-Salas, Jose Manuel. "Statistical treatment of spatial flaws in oligonucleotide microarrays." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510491.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Tjaden, Brian C. "Computational methods for transcription anlysis using oligonucleotide microarrays /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6907.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Eichelsheim, Tanja. "Oligonucleotide based ligands in homogeneous transition metal catalysis." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3168.

Full text

Abstract:

Catalysis plays an important part in our society. Numerous transition metal catalysts have been developed which can convert many different substrates in a wide range of reactions. Catalysis also plays an important role in nature and therefore special catalysts, enzymes, have evolved over time. Enzymes are tremendously efficient giving high yields and selectivities both regio and chemical but have a limited substrate and reaction scope. It was speculated that by combining the two, an ideal catalyst can be obtained. We planned to achieve this by introducing a transition metal, the catalytic cent

APA, Harvard, Vancouver, ISO, and other styles

28

Regberg, Jakob. "Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794.

Full text

Abstract:

Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging from genetic disorders to viral infections and cancer. The problem is that efficient delivery across the cell membrane is required for oligonucleotides to have their desired effect. Cell-penetrating peptides (CPPs) provide a solution to this problem. CPPs are capable of transporting cargoes such as drugs or nucleic acids for gene therapy into the cell, either by covalent conjugation to the cargo or by non-covalent complex formation. This thesis is focused on the development of a class of peptide

APA, Harvard, Vancouver, ISO, and other styles

29

Tazioli, Lia Ashley Maria. "Synthetic approaches to novel, Triazole-containing Oligonucleotide analogues." Thesis, Heriot-Watt University, 2010. http://hdl.handle.net/10399/2442.

Full text

Abstract:

The work reported in this thesis focuses on the development of synthetic approaches to prepare novel triazole-containing nucleic acid (TCNA) monomers for subsequent incorporation into oligomers. The triazole moiety was designed to be prepared using “click chemistry”. Initial studies involved development of viable synthetic pathways for preparation of both the required azide component, derived from L-serine methyl ester and the nucleobase-containing alkyne component. The azide has been successfully synthesised from either protected or unprotected L-serine methyl ester by direct diazotransfer em

APA, Harvard, Vancouver, ISO, and other styles

30

Wallis, Mark P. "Nucleoside and oligonucleotide approaches towards potential HIV chemotherapies." Thesis, Aston University, 1996. http://publications.aston.ac.uk/10936/.

Full text

Abstract:

The use of oligonucleotides directed against the mRNA of HIV promises site-specific inhibition of viral replication. In this work, the effect of aralkyl substituents on oligonucleotide duplex stability was studied using model oligonucleotide sequences in an attempt to improve targeting of oligonucleotides to viral mRNA. Arakyl-substituted oligonucleotides were made by solid phase synthesis using either the appropriate aralkyl-substituted phosphoramidite or by post-synthetic substitution of a pentafluorophenoxy substituent by N-methylphenethylamine. The presence of phenethyl or benzoyl substitu

APA, Harvard, Vancouver, ISO, and other styles

31

Turner, Gillian. "A new protecting group strategy for oligonucleotide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/13149.

Full text

Abstract:

This thesis describes the development of the various methods available for the synthesis of deoxyoligoribonucleotides. The use of the 2,2-bis (4-nitro-phenyl)ethyl group was investigated, mainly as a 5'-hydroxyl protecting group on 2'-deoxyribonucleotides, but also as a base protecting group for the O4-function of thymidinc and the Nc-exocyclic amine of adenosine. The deprotection conditions required for the removal of this group and its subsequent use in the synthesis of 2'-deoxyribonucleotides utilising phosphoramidite methodology arc described. An investigation, by 81P n.m.r., of the coupli

APA, Harvard, Vancouver, ISO, and other styles

32

Udall, Joshua, Lex Flagel, Foo Cheung, et al. "Spotted cotton oligonucleotide microarrays for gene expression analysis." BioMed Central, 2007. http://hdl.handle.net/10150/610000.

Full text

Abstract:

BACKGROUND:Microarrays offer a powerful tool for diverse applications plant biology and crop improvement. Recently, two comprehensive assemblies of cotton ESTs were constructed based on three Gossypium species. Using these assemblies as templates, we describe the design and creation and of a publicly available oligonucleotide array for cotton, useful for all four of the cultivated species.RESULTS:Synthetic oligonucleotide probes were generated from exemplar sequences of a global assembly of 211,397 cotton ESTs derived from >50 different cDNA libraries representing many different tissue types a

APA, Harvard, Vancouver, ISO, and other styles

33

Haker, Ute. "Modifizierung von Silizium-Oberflächen zur Immobilisierung von Biomolekülen." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=959565698.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Kodo, Y. "Synthesis of oligonucleotides and genes." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233499.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Peng, Chang Geng. "Synthesis, characterizations and applications of C2'-modified oligonucleotide analogues." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103030.

Full text

Abstract:

During the past two decades, oligonucleotide analogues have drawn considerable attention as potential therapeutic and diagnostic agents. Gene silencing through "RNA interference" (siRNA) or the more mature "antisense" technology (AONs) have proven to be powerful tools for studying gene functions. Chemical modifications of these compounds are generally required to improve their "drug-like" properties such as potency, selectivity and delivery, particularly in the development of oligonucleotide-based therapeutics. Aptamers are another emerging class of oligonucleotide therapeutics and diagnostics

APA, Harvard, Vancouver, ISO, and other styles

36

Brunner, Jens. "Metallkomplex-funktionalisierte Oligonucleotide und Peptidnucleinsäuren für die DNA-Sequenzerkennung." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973945338.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Chen, Zhongxue. "Probe-level data analysis for high-density oligonucleotide arrays." Ann Arbor, Mich. : ProQuest, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3258524.

Full text

Abstract:

Thesis (Ph.D. in Statistical Science)--S.M.U., 2007.<br>Title from PDF title page (viewed Mar. 18, 2008). Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2429. Adviser: Monnie McGee. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

38

Crawford, Victoria. "The synthesis and study of cell-penetrating oligonucleotide probes." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510903.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Stevens, Lee Anthony. "Relationship between solid support structure and oligonucleotide synthesis performance." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519427.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Battaggia, S. "Approaches toward the synthesis of oligonucleotide 2'0,3'0-cyclic phosphates." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273172.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Hamma, Tomoko. "Biophysical and biochemical studies of anti-HIV oligonucleotide analogs." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068163.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Vilela, Patrick. "Inorganic nanoparticle-oligonucleotide conjugates for bio-sensing and therapeutics." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/426884/.

Full text

Abstract:

In recent years, advances in conjugation techniques have allowed for the development of a vast range of hybrid materials nanomaterials with biomolecules. The use of hybrid nanomaterials has improved the imaging, treatment and diagnostics of specific biological processes. In this project, the main aim was to explore the uses of nanoparticle-oligonucleotide conjugates for biomedical applications. Gold nanoparticle-DNA probes for the intracellular detection of Vimentin mRNA were synthesized. These probes showed great target specificity and biocompatibility. Additionally, by means of light sheet m

APA, Harvard, Vancouver, ISO, and other styles

43

Leung, Ka Ho. "Oligonucleotide-based lunimescent detection platform utilizing iridium (III) complexes." HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/163.

Full text

Abstract:

Luminescent transition metal complexes have arisen as viable alternatives to organic dyes for sensory applications due to their notable advantages. This thesis aimed to synthesize different kinds of Ir(III) complexes, explore their interactions with DNAs and investigate their application for the construction of label-free oligonucleotide-based sensing platforms. A series of Ir(III) complexes incorporating a variety of C^N and N^N donor ligands were synthesized and were shown to exhibit G-quadruplex-selective binding properties via emission titration, UV/vis titration, fluorescence resonance en

APA, Harvard, Vancouver, ISO, and other styles

44

Durand, Adeline. "Synthesis of oligonucleotide analogues for use in DNA nanostructures." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/173975/.

Full text

Abstract:

Thanks to its ability to form duplexes through selective base-pair recognition, DNA is a unique material for orderly self-assembled construction at the nanoscale. To develop a nanotechnology platform on a grid of addressable molecular building blocks using DNA node structures, DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes, phosphoramidites monomers modified with a cholesterol moiety and a spacer unit were synthesised. The hydrophobic spacer provides separation between the hydrophobic cholesterol moiety and the phosphate backbone of the DNA strand.

APA, Harvard, Vancouver, ISO, and other styles

45

Ferrier, David Christopher. "Nucleic acid detection using oligonucleotide cross-linked polymer composites." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28944.

Full text

Abstract:

There has been much interest in recent years about the potential of microRNA as a new source of biomarkers for the diagnosis of disease. The delivery of new diagnostic tools based on this potential has been limited by shortcomings in current microRNA detection techniques. This thesis explores the development of a new method of microRNA detection through the incorporation of conductive particles into oligonucleotide-functionalised polymers to form oligonucleotide cross-linked polymer composites. Such composites could provide a simple, rapid, and low-cost means of microRNA detection that could b

APA, Harvard, Vancouver, ISO, and other styles

46

Rodier, Denise N. "Degenerate Oligonucleotide Primed-PCR: Thermalcycling Modifications and Comparison Studies." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1496.

Full text

Abstract:

Degenerate Oligonucleotide Primed-PCR (DOP-PCR) can potentially enhance analysis of low copy number DNA samples. Theoretically, this procedure replicates fragments of the genome that can then be used for downstream multiplex STR analysis. The objective of this study is to optimize DOP-PCR by examining ramplelongation times and cycle numbers in the non-specific amplification portion of DOP-PCR, and by modifying the degenerate primer. Additionally, other methods such as Multiple Displacement Amplification (MDA) and Low Copy Number PCR (LCN PCR) were examined for their ability to create accurate

APA, Harvard, Vancouver, ISO, and other styles

47

Patel, Ramila. "Delivery and stability of antisense oligonucleotide conjugates in vitro." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10983/.

Full text

Abstract:

The aim of this project was to study the delivery of ODNs to macrophages and to assess the stability of two ODN conjugates, in vitro. The first conjugate aimed to improve uptake of ODNs via mannose receptor mediated delivery, the second investigated the improved delivery of ODN conjugates via non-specific lipophilic interaction with the cell membrane. A mono-mannose phosphoramidite derivative was designed and synthesised and a mono-mannose ODN conjugate synthesised by standard phosphoramidite chemistry. Delivery of this conjugate was enhanced to RAW264.7 and J774 macrophage cell lines via a me

APA, Harvard, Vancouver, ISO, and other styles

48

Guterstam, Peter. "Specificity of antisense oligonucleotide derivatives and cellular delivery by cell-penetrating peptides." Doctoral thesis, Stockholm : Department of Neurochemistry, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-31226.

Full text

Abstract:

Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of doctoral defense, the following papers were unpublished and had s status as follows: Paper 4: Accepted.Peper 5: In press. Härtill 5 uppsatser.

APA, Harvard, Vancouver, ISO, and other styles

49

Williams, Aled. "Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic properties." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/developing-a-new-generation-of-peptidyloligonucleotide-conjugates-with-desired-biocatalytic-properties(a53c3b27-bf03-47d6-b21c-47afb6e96018).html.

Full text

Abstract:

Artificial ribonucleases (ARs) are recognised as a potential strategy to selectively target and cleave biologically significant RNA in cells. However, in order to work as true enzymes they must exhibit catalytic turnover. Many of the reported ARs incorporate metal-containing centres (e.g. dysprosium, copper) in order to induce substantial phosphodiester cleavage, which is not amenable to use in vivo. Therefore, new strategic directions employing metal-independent ARs, such as peptidyl-oligonucleotide conjugates (POCs), need to be investigated. Previous work has shown that poor or non-complemen

APA, Harvard, Vancouver, ISO, and other styles

50

Böhme, Dominik. "Oligonucleotide mit Metallionen-vermittelten Basenpaaren Azol-Nucleoside und ein azyklisches Nucleosidanalogon mit dreizähnigem Liganden." Göttingen Sierke, 2007. http://d-nb.info/987521918/04.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!