Log in

Relevant bibliographies by topics / On biological objects / Dissertations / Theses

To see the other types of publications on this topic, follow the link: On biological objects.

Dissertations / Theses on the topic 'On biological objects'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'On biological objects.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Goldstein, Goldie L. "Smart Temporal Phase Unwrapping for Biological Objects." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311573.

Full text

Abstract:

The development of a quantitative phase microscope (QPM) has allowed the ability to acquire real-time phase movies of biological processes. The image processing of the data is critical to the system's ability to measure relative changes. The phase data must be consistent throughout a measurement and background fluctuations must be minimized. The research presented in this work discusses methods to effectively process sequences of phase data such that it can be used to quantify changes within real-time studies of living cells. This work begins by exploring two-dimensional phase unwrapping to

APA, Harvard, Vancouver, ISO, and other styles

2

Bernier, Thomas. "An adaptable recognition system for biological and other irregular objects /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38150.

Full text

Abstract:

Automated visual recognition and detection processes are becoming increasingly prevalent in almost all scientific fields and being currently implemented in many fields of industry. In most cases, systems are painstakingly designed and developed in order to detect only a single and specific object or property of an object. The objective of this project was to create a framework of development in which any object distinguishable in a two-dimensional digital image could be analyzed and subsequently detected in other images. Furthermore, as new methods are developed, they could be easily incorpora

APA, Harvard, Vancouver, ISO, and other styles

3

BASSI, BARBARA. "Coated gold nano-objects as flexible tools foor biological applications." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203294.

Full text

Abstract:

Le nanostelle di oro (GNSs) mostrano peculiari caratteristiche plasmoniche, che generano proprietà fototermiche e effetti SERS. Questa tesi descrive studi che possiamo raccogliere in due macro-temi: i) substrati vetrosi con ancorato uno strato di GNSs, che di seguito viene ricoperto con strati di diverso spessore e complessità, dei quali si sono studiate le proprietà antibatteriche e di sensing SERS; ii) GNSs in sospensione colloidale, opportunamente ricoperte e equipaggiate con le funzioni desiderate, allo scopo di produrre abilità di sensing, imaging e, in prospettiva, teranostiche.

APA, Harvard, Vancouver, ISO, and other styles

4

Morady, Kamelia. "From objects to action : a neuropsychological analysis." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/454/.

Full text

Abstract:

This thesis is concerned with the factors that determine the performance of everyday action. Six empirical chapters are subsequently presented. First, I sought to investigate the effects of the presence of distractors and of task load on the performance of everyday life tasks, comparing a patient with ADS and controls operating with a task load (Chapter 2). The data indicate that controls and patients with ADS may suffer different demands. The role of the task schema on ADL was examined in Chapter 3. The results showed that there is a problem in using task schema to drive action under the on-l

APA, Harvard, Vancouver, ISO, and other styles

5

Heaton, Luke Latham Moorhouse. "Biological transport networks." Thesis, University of Oxford, 2012. https://ora.ox.ac.uk/objects/uuid:48cf4d64-c051-463c-b9f8-ff50f1a4c2c7.

Full text

Abstract:

Cord-forming fungi form extensive networks that continuously adapt to maintain an efficient transport system, and we can photograph their growth, digitize the network structure, and measure the movement of radio-tracers. Mycelial networks are more accessible than the transport networks of other multicellular organisms, but there are many open questions concerning the coordination of growth and transport within fungal networks. As osmotically driven water uptake is often distal from the growing margin, and aqueous fluids are effectively incompressible, we propose that growth induces mass flows

APA, Harvard, Vancouver, ISO, and other styles

6

Perry, Carole Celia. "Silicification in biological systems." Thesis, University of Oxford, 1985. http://ora.ox.ac.uk/objects/uuid:ae665ac4-63eb-4963-845a-d2db6aea31a6.

Full text

Abstract:

This thesis is concerned with the formation and structure of silicified deposits in biology. The major system studied is silicified macrohairs from the lemma of the grass Phalaris canariensis L. The macrohairs consist of silica and polysaccharides. Chemical and structural studies on the mineral phase utilised electron microscopy (transmission (TEM), scanning (SEM) and ultra high resolution (HRTEM)), energy disoersive X-ray analysis (EDXA), solid state nuclear magnetic resonance ( ᷣ⁹ Si nmr), infrared spectroscopy, birefringence and nitrogen adsorption experiments. Results showed that the sili

APA, Harvard, Vancouver, ISO, and other styles

7

Bernier, Thomas. "Development of an algorithmic method for the recognition of biological objects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29656.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Choi, Seongjin. "Proton NMR and MRI studies of sub-millimeter sized biological objects." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1204559010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Zhou, Renwu. "Direct and indirect activation of biological objects using cold atmospheric plasma." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/131872/2/Renwu%20Zhou%20Thesis.pdf.

Full text

Abstract:

This project was a step forward in the development and application of chemically reactive physical plasmas for direct and indirect treatment of biological objects. The project unravelled the link between plasma-generated chemistry and resultant bioactivity, so as to improve the cold plasma devices for specific applications. The project investigated the interactions of cold plasmas with biological objects including plant seeds, living cells and microorganisms, to provide some theoretical and experimental bases for the development of plasma applications.

APA, Harvard, Vancouver, ISO, and other styles

10

Blazhynska, Marharyta. "Modeling and Standard Binding Free Energy Calculations of Complex Biological Objects." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0149.

Full text

Abstract:

Pendant ma thèse, j'ai consacré mes recherches à l'analyse des calculs d'énergie libre de liaison absolue dans des complexes protéine-ligand. J'ai utilisé des approches basées sur la dynamique moléculaire, intégrant des restreintes telles que les itinéraires alchimiques et géométriques. Mon travail comprenait l'étude de trois complexes protéine-ligand distincts, contribuant ainsi à l'évaluation du logiciel BFEE2 pour l'automatisation de ces calculs. En poursuivant mes investigations, j'ai appliqué cette méthodologie aux interactions protéine-protéine, qui impliquent des phénomènes de reconnais

APA, Harvard, Vancouver, ISO, and other styles

11

Li, Gang Gang. "Biological studies of distraction osteogenesis." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:d2976713-d0f6-439a-a70c-9183d44cff81.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Taylor, Cameron S. "Characterisation of engineered nanoparticles and their interaction with natural biological and non-biological material." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:03810528-de65-4094-907c-8c0d4e0386c8.

Full text

Abstract:

Form, mobility, toxicity and the eventual fate of engineered nanomaterials in environmental ecosystems are currently not well defined and are needed to improve risk assessment and legislation. The present study subjected uncoated zinc oxide (ZnO) nanoparticles (30nm and 200nm) and coated silver (Ag) nanoparticles (Paraffin: 3-8nm and citrate/PVP: 50nm) to different ionic strength media and different types of algal/bacterial extracellular-polymeric species (EPS) at long (6 months) and short (2 weeks) timescales. Changes in particle size distribution and stability were examined using a multi-met

APA, Harvard, Vancouver, ISO, and other styles

13

Huguet, Casades Gemma. "The role of hyperbolic invariant objects: From Arnold diffusion to biological clocks." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/5856.

Full text

Abstract:

El marc d'aquesta tesi són els objectes invariants hiperbòlics (tors amb bigotis, cicles límit, NHIM,. . .), que constitueixen, per aquesta tesi, els objectes essencials per a l'estudi de diversos problemes des de la difusió d'Arnold fins als rellotges biològics. Treballem en tres temes diferents des d'un enfocament tant teòric com numèric, amb una especial atenció per a les aplicacions, especialment en neurobiologia:<br/>· Existència de difusió d'Arnold per a sistemes Hamiltonians a priori inestables<br/>· Algorismes numèrics ràpids per al càlcul de tors invariants i els "bigotis" associats,

APA, Harvard, Vancouver, ISO, and other styles

14

Crawford, David Michael. "Analysis of biological pattern formation models." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:aaa19d3b-c930-4cfa-adc6-8ea498fa5695.

Full text

Abstract:

In this thesis we examine mathematical models which have been suggested as possibile mechanisms for forming certain biological patterns. We analyse them in detail attempting to produce the requisite patterns both analytically and numerically. A reaction diffusion system in two spatial dimensions with anisotropic diffusion is examined in detail and the results compared with certain snakeskin patterns. We examine two other variants to the standard reaction diffusion system: a system where the reaction kinetics and the diffusion coefficients depend upon the cell density suggested as a possible mo

APA, Harvard, Vancouver, ISO, and other styles

15

Bennett, Philip Mark. "Two-photon dyes for biological application." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:b8cb9ce4-35eb-433c-86fc-b5df53a2e566.

Full text

Abstract:

Two photon absorption (TPA) is the near simultaneous absorption of two photons of light to achieve an electronically excited state. It has led to huge advances in microscopy and microfabrication due to its quadratic dependence on the local light intensity. This thesis describes the design, synthesis and application of dyes with strong TPA properties, and as such is divided into three chapters. The first introduces the theory and measurement of TPA as well as structure-property relationships known to maximise the efficiency of TPA. The subsequent chapters present explorations of the application

APA, Harvard, Vancouver, ISO, and other styles

16

Hardcastle, Rohan J. "Legal protection of human biological materials." Thesis, University of Oxford, 2005. https://ora.ox.ac.uk/objects/uuid:5ab37a9c-0780-46a7-a228-685020a429af.

Full text

Abstract:

Do you own your body? Advances in science and the development of genetic databases have given this question an aura of modern controversy. However, English law governing separated biological materials is in an unsatisfactory state. Despite the enactment of the Human Tissue Act 2004 UK, it is not clear, for example, what property rights or non-proprietary interests living persons can claim over their separated biological materials. The development of clear legal principles is necessary, however, to enable individuals to have effective control over such materials and to enable the efficient use

APA, Harvard, Vancouver, ISO, and other styles

17

De, Munari Sonia. "Biological investigation of glycosylated macromolecular structures." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:3899afcb-a9c0-4e15-8fd0-c2eff8d5e6b3.

Full text

Abstract:

Carbohydrates play a key role in many biological processes. The complex pool of information that these structures are able to express forms the glycocode. Our understanding of this language is limited, due to the complexity of the sugar structures and the diversity of their functions. The work presented in this thesis aims to contribute to our knowledge of their biological significance by building what we will call a Glycomap, a selection of biologically relevant sugars specifically picked to map the in vivo interactions of carbohydrates and explore some of their applications to different macr

APA, Harvard, Vancouver, ISO, and other styles

18

Li, Zhaohui. "Monitoring biological functions of cultured tissues using microdialysis." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:f8b478fa-881e-4299-9ee5-b8ee29f37fe9.

Full text

Abstract:

Continuous monitoring during tissue culture is important for the success of engineered tissue development. It is also challenging due to lack of suitable established monitoring techniques. In this study, microdialysis, a sampling technique for measuring the unbound solute concentrations in the tissues and organs of the living body, was adopted to monitor functional tissue growth in a bioreactor with explanted bovine caudal intervertebral discs (IVD) as the test tissue. Apart from cell metabolic activities, cell and tissue biological functions were investigated for the development of microdialy

APA, Harvard, Vancouver, ISO, and other styles

19

Seet, Li Fong. "Characterization of the biological properties of FGF-9." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:a46cee92-c179-4d22-b27b-0e67c3c85a37.

Full text

Abstract:

The fibroblast growth factor family of polypeptides currently consists of nine structurally-related members. Cloning of the mouse homologue of the latest reported member of the family, FGF-9, is described in this study. Mouse Fgf9 exhibits a high level of sequence conservation with the human, rat and Xenopus counterparts. Of note is the lack of a hydrophobic signal peptide at the N-terminus of the coding sequence. The protein, however, appeared to be secreted by producer cells since a significant quantity of the protein could be purified from the culture supernatant of transfected cells. Membe

APA, Harvard, Vancouver, ISO, and other styles

20

Bradshaw, Jeremy Peter. "A study of the structure of biological macromolecules." Thesis, University of Oxford, 1985. http://ora.ox.ac.uk/objects/uuid:e7d9dce0-b5f8-4e24-96c2-8fe79c273ae6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Quinson, Jonathan. "Tailored carbon-based nanomaterials for biological energy electrocatalysis." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:c46dcc1d-67cf-4e93-9eb6-fc6bf6cc8e07.

Full text

Abstract:

Hydrogenases are energy relevant bio-electrocatalysts. Their study and applications require immobilisation on carbon scaffolds and benefit from carbon materials design. The present thesis first compares eleven carbon materials for the adsorption of hydrogenase-1 from E. coli. All of them accommodate the enzyme in an electroactive configuration. A high surface area and/or abundance of 'edge' carbon planes are identified as important features to improve studies and applications of hydrogenases. The nanomaterials screened facilitate the coupling of infrared spectroscopy and electrochemistry for s

APA, Harvard, Vancouver, ISO, and other styles

22

Honti, Frantisek. "A method for the identification of biological pathways." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e7079080-a814-431a-badd-35080f5a2825.

Full text

Abstract:

Plenty of gene variants have been associated with disease, indicating widespread genetic heterogeneity, which leaves the molecular basis of complex diseases unclear. However, it is widely postulated that the products of genes whose mutations are implicated in the same disease function together in the same biological pathways and it is the disruption of these pathways that underlies the disease. Such pathways are not well defined and their identification could help elucidate disease mechanisms. To discern molecular pathways of relevance to complex disease, I have inferred functional association

APA, Harvard, Vancouver, ISO, and other styles

23

Wilson, Henry R. "An NMR study of biological phosphate interactions." Thesis, University of Oxford, 1986. https://ora.ox.ac.uk/objects/uuid:4b6db023-5fca-467c-9a92-877f435d417d.

Full text

Abstract:

An investigation is made of the interactions between a variety of small molecule phosphates and amines, and in particular of triethylenetetramine with hexametaphosphate, pyrophosphate, tripolyphosphate, ADP and ATP and of cyclic triethylenetriamine with hexametaphosphate. For each phosphate/amine pair, observed changes in the pH dependence of <sup>1</sup>H and <sup>31</sup>P nmr chemical shift are used to calculate the effect of interaction on the pK<sub>a</sub> of the two species present and an association constant is evaluated at one particular pH value. These data are then combined to evalu

APA, Harvard, Vancouver, ISO, and other styles

24

Cooper, Jonathan Paul. "Automatic validation and optimisation of biological models." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:24b96d62-b47c-458d-9dff-79b27dbdc9f2.

Full text

Abstract:

Simulating the human heart is a challenging problem, with simulations being very time consuming, to the extent that some can take days to compute even on high performance computing resources. There is considerable interest in computational optimisation techniques, with a view to making whole-heart simulations tractable. Reliability of heart model simulations is also of great concern, particularly considering clinical applications. Simulation software should be easily testable and maintainable, which is often not the case with extensively hand-optimised software. It is thus crucial to automate

APA, Harvard, Vancouver, ISO, and other styles

25

Thinnes, Cyrille Christophe. "Chemical and biological studies on human oxygenases." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:455f2e65-f294-461b-b44f-cd53796b14a0.

Full text

Abstract:

As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development of selective small molecules for functional studies in vivo. The non-selective metal chelator 8-hydroxyqui

APA, Harvard, Vancouver, ISO, and other styles

26

Duan, Xuchen. "Physiological and biological mechanisms of bisphosphonate action." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:36b0439d-2f89-4c1e-8bb3-941b4e6ee847.

Full text

Abstract:

Bisphosphonates (BPs) are stable analogues of pyrophosphate widely used for the treatment of bone diseases characterised by increased bone resorption. Studies over the years have shown that the pharmacological potencies of BPs are dependent both on their binding affinities for bone mineral and on their inhibitory actions on osteoclasts. In addition, potential effects on other cell types present locally in the environment of skeletal tissues have been reported. The present study systematically evaluated the relative mineral-binding affinities of individual BPs of clinically relevance in mixture

APA, Harvard, Vancouver, ISO, and other styles

27

Patel, Mitul Kiran. "Unravelling the biological roles of charged carbohydrates." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:6fb4de15-5585-4f62-ae56-4c6bf32593ab.

Full text

Abstract:

The phosphate and sulfate esters of carbohydrates are widespread in nature, where they partake in a variety of signalling roles. This thesis focuses on the involvement of trehalose-6-phosphate (Tre-6-P) in regulating plant growth, and the function of sulfated carbohydrates in the immune response. In plants, Tre-6-P is a critical messenger that conveys environmental information for the control of metabolic state. Beneficial natural conditions lead to an increase in the in vivo concentration of Tre-6-P, which in turn triggers biosynthetic processes facilitating plant growth. However, the mechani

APA, Harvard, Vancouver, ISO, and other styles

28

Shao, Bing. "Applying optical forces and elastic light scattering for manipulation and analysis of biological objects." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3220416.

Full text

Abstract:

Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed September 8, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

29

Kiappes, John Leon. "Synthesis and biological characterization of natural and designed sugars." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:ccc0e4dd-a8b4-445b-9fee-260c35b0040d.

Full text

Abstract:

Carbohydrates represent a keystone among biological molecules. Well known as a source of energy, sugars also form the backbone of various biopolymers, act as markers and receptors for cellular communication and modulate lipid and protein functions. As such a powerful class, carbohydrates represent a useful pool from which both nature and man have drawn structures to produce biologically active compounds with a variety of modes of action. Beyond their importance to biology, sugars have represented attractive synthetic targets to chemists given their densely functionalized scaffolds. The work pr

APA, Harvard, Vancouver, ISO, and other styles

30

Korzycka, Karolina Anna. "Two-photon sensitive protecting groups for biological application." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:7e895ed2-04a5-4c0b-9105-74461eae8796.

Full text

Abstract:

Caged compounds are a class of photosensitive reagents used to stimulate cells with spatial control down to a sub-cellular level, and millisecond temporal control. They comprise of biologically important molecule which is modified with a photolabile protecting group. In the absence of light, caged compounds are physiologically silent but irradiation with light induces the release of biologically active species. Illumination under two-photon conditions is particularly advantageous as it enables restriction of the photolysis volume to ~1 fL and it provides deeper penetration into scattering samp

APA, Harvard, Vancouver, ISO, and other styles

31

Sarphie, David F. "Gas propulsion of microprojectiles for the transformation of biological cells." Thesis, University of Oxford, 1992. https://ora.ox.ac.uk/objects/uuid:c78bb189-665d-4199-8a0b-ce0b439389c7.

Full text

Abstract:

Bombardment of intact cells and tissue with DNA-coated microprojectiles represents a novel approach to the genetic transformation of biological material. In this thesis, a gas propulsion particle gun is developed for such a purpose. The particle gun utilises gas dynamics to control particle velocity and spread, thereby enabling optimisation of transformation efficiencies for varying types of target material. The dynamics associated with particle acceleration are shown to relate to transient, shock tube flow. Measurements from schlieren high-speed video photographs of the shock structure of an

APA, Harvard, Vancouver, ISO, and other styles

32

Herre, Jürgen. "Dectin-1 : receptor internalisation, trafficking and biological effects in macrophages." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:bb525976-bfbf-4817-926b-c3686da071b5.

Full text

Abstract:

In host defence, pattern recognition plays an essential role by enabling the immune system to discriminate self from pathogenic non-self. Pattern recognition is mediated by leukocyte expressed pattern recognition molecules (PRMs), which recognise pathogen associated molecular patterns (PAMPs) on pathogens. Phagocytosis is a critical event for anti-microbial defence and its contribution is not limited to the clearance and killing of pathogens, but extends to the activation of adaptive immunity through production of pro-inflammatory mediators and antigen presentation. Anti- fungal immunity is ex

APA, Harvard, Vancouver, ISO, and other styles

33

Crabtree, Elizabeth Victoria. "The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:abe6fa1a-1922-45ee-b1f2-740247242129.

Full text

Abstract:

Iminosugars are known to behave as carbohydrate mimics in biological systems by virtue of their similar structures. However as the ring nitrogen prevents metabolism it means that iminosugars have the potential to become inhibitors of these systems. It is known, for example, that iminosugars can behave as mimics in the hydrolysis mechanism. This leads to possible medicinal applications of iminosugars. One such case is lysosomal storage disorders which arise as a result of a genetic defect which causes missense mutations coding for the N-acetylhexosaminidase enzymatic protein. N-Acetylhexosamini

APA, Harvard, Vancouver, ISO, and other styles

34

Liu, Zilei. "Synthesis and biological evaluation of rare monosaccharides and their mimics." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:bc101d4a-f19b-4a2e-816c-fa7db7936a6d.

Full text

Abstract:

This thesis describes work in the synthesis and biological evaluation of different carbohydrates and their derivatives. Azetidine carboxylic acid (Aze), as a pharmacophore in medicinal chemistry, is attracting more and more researchers in recent years. As a four membered ring analogue of proline, this nature occurring compound can be mis-incorporated into proteins and can cause changes in protein conformation and therefore induce toxic effects. It is therefore useful to study how Aze and its derivatives affect protein confirmation. Previous research has identified some azetidine iminosugars to

APA, Harvard, Vancouver, ISO, and other styles

35

Robinson, Alan Jonathan. "The computer simulation of lipid bilayers and biological membranes." Thesis, University of Oxford, 1996. https://ora.ox.ac.uk/objects/uuid:787e13b4-4a3e-44ce-bd2d-9bb847631a5d.

Full text

Abstract:

Computer simulations of lipid bilayers and biological membranes using molecular mechanics calculations have been undertaken in order to study these complex systems which are so vital in the control and functioning of many biological processes. The preliminary research involved the development of a model that recreates experimentally observed properties. This is not a trivial task since structural data on lipids in the biologically relevant liquid crystalline phase are unavailable precisely because of their fluid nature. The starting configuration designed for simulation of lipids in the fluid

APA, Harvard, Vancouver, ISO, and other styles

36

Liao, Shuohao. "High-dimensional problems in stochastic modelling of biological processes." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2d710a16-e790-47eb-8670-a4dcdd86f143.

Full text

Abstract:

Stochastic modelling of gene regulatory networks provides an indispensable tool for understanding how random events at the molecular level influence cellular functions. A common challenge of stochastic models is to calibrate a large number of model parameters against the experimental data. Another difficulty is to study how the behaviour of a stochastic model depends on its parameters, i.e. whether a change in model parameters can lead to a significant qualitative change in model behaviour (bifurcation). This thesis addresses such computational challenges by a tensor-structured computational f

APA, Harvard, Vancouver, ISO, and other styles

37

Phanumartwiwath, Anuchit. "Novel halogenation and pallado-biology strategies for biological probes." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:65892f29-353e-471a-9dfa-b3fc7e2f806d.

Full text

Abstract:

Post-translational modifications (PTMs), which biochemically modify proteins to generate diversity and control functionality, are important in the field of chemical biology research. However, typical bioconjugation methods involving nucleophilic addition of cysteine and lysine residues are limited by their lack of site-specificity. In this thesis, we have demonstrated the site-selective chemical modification of a variety of proteins through protein halogenation and subsequent pallado-biology strategies. The "Tag-and-Modify" approach, developed previously in our group and involving the creation

APA, Harvard, Vancouver, ISO, and other styles

38

Taylor, Paul. "Stochastic lattice-based models of diffusion in biological systems." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4279d4cb-8044-4907-be36-a9bce47a37a7.

Full text

Abstract:

Diffusion is a universal phenomenon, throughout both biological and physical sciences, and a range of deterministic and stochastic models are available to interrogate diffusion-driven processes. Stochastic models are more computationally intensive to simulate, but may be necessary in situations where deterministic models lead to qualitatively different results. Stochastic lattice-based position-jump (LBPJ) models are a popular framework for representing diffusion. Particles reside within discrete compartments, and may jump to other compartments or react with other particles sharing the same co

APA, Harvard, Vancouver, ISO, and other styles

39

Entwistle, Ngai Mun Aiman. "Actuation of DNA cages and their potential biological applications." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:0983ed77-77f6-4d15-9187-52aff44299ec.

Full text

Abstract:

DNA cages are polyhedra self-assembled from synthetic oligonucleotides in a one-pot process. The main system described in this thesis is a reconfigurable, wire-framed DNA tetrahedron in nanometre-scale. On one of its vertices this tetrahedron has an overhang that can hybridise with a specific sequence of nucleic acids and open the cage. We describe the design of a reconfigurable cage that remained closed under physiological conditions and only opened in the presence of an appropriate signal in solution. Fluorescence techniques were employed to distinguish the open and closed states of the cage

APA, Harvard, Vancouver, ISO, and other styles

40

Paczkowski, Marcin. "Biological interactions between cell populations in heterogeneous tumour spheroids." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:91853f0a-9bb5-4190-a731-7bbe2d68bfff.

Full text

Abstract:

When radiotherapy is prescribed in the clinic, the tumour is assumed to be homogeneous. However, tumours are composed of many distinct cell populations that interact with each other and their environment. It is unclear how this heterogeneity affects tumour growth and response to treatment. Additionally, much of cancer research considers tumour cells in isolation, neglecting the context in which the disease develops. Experimental approaches alone are not suficient to understand the complexity of the interactions occurring in the cancer ecosystem. In this thesis we use a multidisciplinary approa

APA, Harvard, Vancouver, ISO, and other styles

41

Tait, Claudia E. "Electron paramagnetic resonance studies of artificial supramolecular structures and biological systems." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:b0535d55-89aa-4d89-b210-b49caf6b857e.

Full text

Abstract:

The research described in this thesis employs a variety of Electron Paramagnetic Resonance (EPR) techniques for the study of the electronic and structural properties of artificial supramolecular porphyrin systems and of protein complexes of biological relevance. The electron delocalisation in the cationic radical and photoexcited triplet states of linear and cyclic Π-conjugated multiporphyrin arrays was investigated. In the radical cations, information on the extent of delocalisation can be inferred from the measurement of hyperfine couplings, either indirectly from the continuous wave EPR

APA, Harvard, Vancouver, ISO, and other styles

42

Bhushan, Bhaskar. "Unnatural amino acids as metal-mediated probes of biological function." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4b1cbed6-1151-4b9f-ad97-aa5765cc9384.

Full text

Abstract:

Conjugation reactions on proteins have been used to access various post-translational modifications, for targeted delivery of drugs, for microscopy, and in studying receptor-ligand interactions. However, the ability to modify native proteins is constrained by the reactive functionalities of naturally occurring amino acids. This has driven research into the incorporation of unnatural amino acids (UAAs) into proteins. Research in this area has been motivated both by the possibility of increasing the breadth of chemical techniques for protein modification by introducing novel 'bio-orthogonal' rea

APA, Harvard, Vancouver, ISO, and other styles

43

Parton, Daniel L. "Pushing the boundaries : molecular dynamics simulations of complex biological membranes." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:7ab91b51-a5ae-46b4-b6dc-3f0dd3f0b477.

Full text

Abstract:

A range of simulations have been conducted to investigate the behaviour of a diverse set of complex biological membrane systems. The processes of interest have required simulations over extended time and length scales, but without sacrifice of molecular detail. For this reason, the primary technique used has been coarse-grained molecular dynamics (CG MD) simulations, in which small groups of atoms are combined into lower-resolution CG particles. The increased computational efficiency of this technique has allowed simulations with time scales of microseconds, and length scales of hundreds of nm

APA, Harvard, Vancouver, ISO, and other styles

44

O'Keeffe, Stephen George. "The mechanics of growth and residual stress in biological cylinders." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:493473f6-b952-4ce3-a2e5-1a79e97afb7f.

Full text

Abstract:

Biological tissue differs from other materials in many ways. Perhaps the most crucial difference is its ability to grow. Growth processes may give rise to stresses that exist in a body in the absence of applied loads and these are known as residual stresses. Residual stress is present in many biological systems and can have important consequences on the mechanical response of a body. Mathematical models of biological structures must therefore be able to capture accurately the effects of differential growth and residual stress, since greater understanding of the roles of these phenomena may hav

APA, Harvard, Vancouver, ISO, and other styles

45

Johnston, Iain G. "Exploration, exploitation & complexity in biological evolution and self-assembly." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:9dbf2fdc-219b-48dd-8bb7-2c6031070dc1.

Full text

Abstract:

Self-assembly --- by which ordered structures spontaneously emerge from disordered components --- and biological evolution --- by which Charles Darwin's "endless forms most beautiful" have emerged from the simple chemistry of prehistoric Earth --- may both be pictured as search processes on high-dimensional landscapes, defined respectively by the concepts of energy and fitness. The rich dynamics of these search processes will be studied in order to explain biologically observed features of self-assembly and evolution. This study will introduce and analyse the behaviour of a model for a paradig

APA, Harvard, Vancouver, ISO, and other styles

46

Brazauskas, Pijus. "The biological role of DNA modifications deposited over gene bodies." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:807458f2-1c34-4474-a0c5-0f82abe7640e.

Full text

Abstract:

5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the most common DNA modifications in vertebrate genomes. Promoter-residing 5mC is a well-established transcriptional repression mark. However, the role of gene body DNA modifications, especially those involving 5hmC, remains elusive and controversial. In this study, the role of genic 5mC and 5hmC in transcriptional regulation is investigated. By engineering a cell line with inducible 5hmC it is shown that deposition of 5hmC causes elevated expression of genes with the highest accumulation of this modification. The transcriptional el

APA, Harvard, Vancouver, ISO, and other styles

47

Uapipatanakul, Boontida. "Harmonising metalworking fluid formulations with end-of-life biological treatment." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:83a01f43-e9e2-42cb-a23c-cbc31b3ba1b5.

Full text

Abstract:

Metalworking fluids (MWFs) are coolants and lubricants, which are widely employed in metal cutting works. They are designed to be a long lasting product. Manufacturers have designed MWFs with lack of awareness of end-of-life disposal by including biocides, which make biological treatment challenging. Here, Syntilo 9913 was used as a case study to develop a cradle-to-grave product that was biologically stable in use but amenable to sustainable hybrid biological treatment at end-of-life. The product was reverse engineered employing factorial design approach based on a priori knowledge of the pro

APA, Harvard, Vancouver, ISO, and other styles

48

Prodöhl, Carsten. "On the recognition of objects by contour parts and the early development of biological contour processing." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=978875621.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Johnson, Eachan Oliver Daniel. "Protein-protein recognition in biological systems exhibiting highly-conserved tertiary structure : cytochrome P450." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d19f5f52-d1ce-4ec2-be83-fd52f01124f8.

Full text

Abstract:

Protein tertiary structure is more conserved than amino acid sequence, leading to a diverse range of functions observed in the same fold. Despite < 20 % overall sequence identity, cytochromes P450 all have the same fold. Bacterial Class I P450s receive electrons from a highly specific, often unidentified, ferredoxin, in which case the hemoprotein is termed “orphaned”. CYP199A2, a Class I P450, accepts electrons from ferredoxins Pux and HaPux. Five orientation-dependent and one orientation-independent DEER measurements on paramagnetic HaPux and spin-labelled CYP199A2 yielded vector restraints,

APA, Harvard, Vancouver, ISO, and other styles

50

Luecken, Malte. "Application of multi-resolution partitioning of interaction networks to the study of complex disease." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:b49187be-8203-4aa0-abbd-bff1a507ff6f.

Full text

Abstract:

Large-scale gene expression studies are widely used to identify genes that are differentially expressed between phenotypes relevant to disease. Often thousands of differentially expressed genes (DEGs) are found using this type of analysis, which complicates the interpretation of the data. In this project we treat DEGs as windows into the biological processes that underlie disease. In order to find these processes, we put DEGs into the context in which they perform their functions - through the interactions of their protein products. Protein-protein interactions can provide biological context t

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!