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Dissertations / Theses on the topic 'Onchocerciasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Goodrick, Lucy Elisabeth. "Immune responses in human onchocerciasis." Thesis, University of Salford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301417.

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2

Kuo, Yien Ming. "Antigen recognition in experimental onchocerciasis." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46399.

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3

Tree, Timothy Ian Martin. "Molecular characterisation of Onchocerca volvulus antigens." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321651.

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4

Baxter, Andrea Joy. "Studies on immunity to infection and the response of trauma of British Simulium species." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243113.

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5

Ali, Magdi Mahmoud. "Immunologic aspects of the pathogenesis of human onchocerciasis." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-793.

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<p>Onchocerciasis, or river blindness, is a parasitic disease that affects more than 20 million people globally. The induction of pathology is directly related to the presence and destruction of the microfilarial stages (mf) of this filarial nematode. The disease presents clinically with a wide spectrum of dermal and ocular manifestations, the basis of the variation is believed to involve the immune system. The clinical presentations of infected hosts relate to the intensity of the reactions against the parasite. Anti-microfilarial drugs are also thought to somehow involve the immune system in

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6

Osei-Atweneboana, Mike Yaw 1966. "Molecular epidemiology of emerging ivermectin resistance in onchocerciasis." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111910.

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Onchocerciasis, commonly known as "River blindness" is a disease affecting over 37 million people, worldwide. It is caused by the parasitic nematode Onchocerca volvulus and transmitted by the blackfly vector of the genus Simulium. The drug ivermectin (IVM) is the principal means of controlling the disease. As a result of recent reports on sub-optimal response to ivermectin and genetic selection in O. volvulus, we carried out a 21 month epidemiological study to investigate the response of O. volvulus to repeated rounds of IVM treatments in 2501 subjects from 19 Ghanaian communities that have re

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7

Ali, Magdi Mahmoud M. "The immunologic aspects of the pathogenesis of human onchocerciasis /." Stockholm : Dept. of immunology, Wenner-Gren institute, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-793.

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8

McCall, Philip John. "Studies on the transmission of bovine onchocerciasis in North Wales." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328187.

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9

Cooper, Philip. "Onchocerciasis in Ecuador : a cellular immunological and epidemiological investigation of chorioretinopathy." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338137.

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10

Cross, Helen Fiona. "A molecular and pharmacological investigation of the action of ivermectin against Onchocerca ochengi of cattle." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266171.

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11

Njongmeta, Leo Moh. "Immunity in onchocerciasis after ivermectin prophylaxis : studies with Onchocerca ochengi in cattle." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250397.

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12

Koroma, J. B. "Preventive chemotherapy for elimination of lymphatic filariasis and onchocerciasis in Sierra Leone." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008028/.

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Lymphatic filariasis (LF) and onchocerciasis are highly endemic in Sierra Leone. Using World Health Organization (WHO) guidelines for monitoring national programmes where both infections are co-endemic, this study aimed to determine the impact of preventive chemotherapy on transmission intensity by measuring changes in human infection status using standard epidemiological indicators. Separate longitudinal studies designed to deliver WHO outcomes for programmes targeting the elimination of both diseases were conducted. Onchocerciasis mapping surveys from 1988-2005 revealed that twelve of fourte

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13

Duprez, Jessica Anais Sybille. "Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28976.

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Onchocerciasis, caused by Onchocerca volvulus remains a major public health and socio-economic problem across the tropics, despite years of mass drug administration (MDA) with Ivermectin to reduce disease burden. Through modelling, it has been shown that elimination cannot be achieved with MDA alone and additional tools are needed, such as vaccination, which remains the most cost-effective tool for long-term disease control. The feasibility behind vaccination against O. volvulus can be demonstrated in the Litomosoides sigmodontis mouse model, which shows that vaccine induced protection can be

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14

Mackenzie, Charles. "Studies on the pathogenesis and control of parasitic infections." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/16714.

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The work represented in this thesis covers three areas: the pathogenesis and immunobiology of nematode infections, the control and elimination of filarial nematode diseases, and lastly contributions to experimental and diagnostic pathology involving different diseases and medical conditions. A number of fundamental concepts are addressed: the role of eosinophil leucocytes in directly killing certain stages of helminths, acting in conjunction with antibodies and complement; the clinical significance of cell mediated immune responses in human onchocerciasis and its relationship to the clinical v

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15

Guzmán, Laparra Gabriel Eduardo. "Use of affordable technology for the sensitive and specific diagnosis of onchocerciasis (river blindness) /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-321-x.

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16

O'Hanlon, Simon. "Spatial and temporal distribution of onchocerciasis in West Africa, with particular reference to Ghana." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/59136.

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Background. Quantifying and predicting the effect of control interventions against infectious diseases requires knowledge about prevalence prior to the implementation of such control measures as well as knowledge of key parameters which affect model outcomes. Here is presented the first geostatistical map estimating the prevalence of human onchocerciasis in the former Onchocerciasis Control Programme in West Africa (OCP) before the initiation of vector control operations in 1975. The map is used to quantify the burden of onchocercal skin disease prior to interventions. The results of a socioec

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17

Barro, Alassane Sie. "Using Geographic Information Systems for Onchocerciasis control in Africa: case of Ghana and Burundi." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/636.

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Onchocerciasis is a blindness-causing disease caused by a nematode called Onchocerca volvulus that is transmitted by Simulium blackflies. The disease is a major epidemiological problem among rural communities living in close proximity to rivers in some population in Sub-Saharan Africa. Recent studies identified Ghana to be a treat of recrudescence of onchocerciasis in neighboring countries. This thesis applies spatial models, predicts, and assesses population at risk of onchocerciasis in Ghana. It also evaluates the disease endemicity in Burundi in order to test the models applied in Ghana. On

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18

Katawa, Gnatoulma [Verfasser]. "The Role of T helper 17 cells in the pathogenesis of human onchocerciasis / Gnatoulma Katawa." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077289618/34.

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19

DE, ANGELIS FLAVIO. "HLA DQ and onchocerciasis in Ecuador: interactions between genetics and environment in an endemic infection." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1374.

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Il genoma umano tende ad essere gradualmente modificato dalla selezione naturale a causa dell’interazione con diverse condizioni ambientali che possono essere considerate veri e propri fattori selettivi. Lo scopo della presente ricerca è quello di esplorare la variabilità ai loci HLA DQA1 e HLA DQB1 in due popolazioni coresidenti nella foresta pluviale lungo il fiume Rio Cayapa (nord-ovest Ecuador) ed esposti ai medesimi stress ambientali, tra cui l'infezione da O. volvulus. I loci HLA di classe II (HLA DQA1 e DQB1) di 211 individui appartenenti a due distinte popolazioni (Indios Cayapas ed in

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20

Halstead, Meredith. "Putative glutamate-gated chloride channels from Onchocerca volvulus." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29439.

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Onchocerca volvulus, a filarial nematode, is the causative agent of onchocerciasis.<br>O. volvulus is a human parasite with no animal model host and is endemic in the tropics. O. volvulus material is scarce and must be conserved as part of the Onchocerciasis Control Program. A genomic library was constructed to provide a substantial source of renewable genetic material, in place of original parasite DNA.<br>Currently there is only one glutamate-gated chloride channel that has been sequenced from O. volvulus, but this has not yet been characterized. This GluClx partial cDNA sequence isolated by

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21

Rodriguez, Perez Mario Alberto. "Assessment and monitoring of onchocerciasis control in Mexico : application of novel immunological and molecular diagnostic tests." Thesis, University of Salford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301432.

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22

Millest, Alice Lucy. "The Simulium ochraceum and S. metallicum species complexes in Mexico : identification, distribution and relation to onchocerciasis." Thesis, University of Southampton, 1989. https://eprints.soton.ac.uk/192467/.

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Both S.ochraceum and S.metallicum, which are vectors of onchocerciasis, are now known to be species complexes (Hirai et in preparation; Conn, 1988). Larval collections were made in a variety of streams in the three onchocerciasis foci in Mexico and identified by cytotaxonomic criteria. S.ochraceum cytotype A was found in the Soconusco focus, cytotype B in the Oaxaca focus and cytotype C in the Chamula focus. Cytotype C was recorded in Mexico for the first time. S.metallicum cytotypes A, B, H and I were found in all three of the foci. Cytotypes B, H and I were recorded in Mexico for the first t

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23

Schorscher, Judith A. (Judith Anne). "Insect predators of larval Simulium damnosum Theobald, vector of onchocerciasis, and other Simulium species in Southern Sudan." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63254.

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24

Evans, Timothy Grant. "The socio-economic consequences of human disease on subsistence agriculture : the case of onchocerciasis in West Africa." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305807.

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25

Talsma, Alex Jeanne. "Development of a Confirmatory PCR Assay to Detect Onchocerca volvulus in Pools of Vector Black Flies." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4952.

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Onchocerciasis, or river blindness, has historically represented one of the significant neglected tropical diseases on the planet in terms of socio-economic impact. The discovery that ivermectin was a safe and effective treatment for onchocerciasis, together with the decision of the manufacturer to donate the drug for the treatment of this disease became the basis for several large international programs to control and eventually eliminate the infection. These programs have managed to virtually eliminate transmission of the parasite causing Onchocerca volvulus from many foci in Africa and th

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26

Mafuyai, Hayward Babale. "Studies on the taxonomy and distribution of the Simulium daminsum complex in Nigeria, in relation to human onchocerciasis." Thesis, University of Salford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357116.

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27

Wilson, Michael David. "Morphological and molecular methods for the identification of adult female Simulium damnosum species complex (Diptera: Simuliidae) vectors of onchocerciasis." Thesis, University of Salford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239997.

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28

Adamu, Robert. "Molecular and Functional Characterization of Onchocerca volvulus Gene Products (Ov58GPCR and Ov-DKR-1) in the Control of Human Onchocerciasis." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/279609.

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Onchocerciasis is a severely debilitating yet neglected tropical disease (NTD) currently affecting approximately 15.5 million people, including 12.2 million people with skin disease and 1.025 million with vision loss. The disease causes social stigma, generates and perpetuates poverty, and leads ultimately to irreversible unilateral or bilateral blindness if untreated. Consequently, onchocerciasis is a major impediment to socioeconomic development in addition to being a major public health concern in some African countries. Many control programs have been launched against the disease with mode

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29

Chesnais, Cédric. "Recherches épidémiologiques appliquées à la lutte contre les filarioses en Afrique centrale." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T016/document.

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Le Programme africain de lutte contre l'onchocercose (APOC) et le Programme mondial d'élimination de la filariose lymphatique (GPELF), basés respectivement sur des traitements de masse par ivermectine et par une combinaison d'ivermectine et d'albendazole, sont des succès indéniables. Cependant, en Afrique centrale, région endémique pour la loase, les opérations de lutte sont fortement entravées du fait de la survenue possible d'effets secondaires graves induits par l'ivermectine chez les individus présentant plus de 30.000 microfilaires de Loa loa par mL de sang. Les résultats remarquables de

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30

Evans, Darin S. "Onchocerciasis, lymphatic filariasis, soil transmitted helminthiasis, and schistosomiasis: integration and economic evaluation of mass drug administration using ivermectin, albendazole, and praziquantel." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12756.

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Thesis (Dr.P.H.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>The recently classified neglected tropical diseases (NTD), -- onchocerciasis, lymphatic filariasis, schistosomiasis, and soil-transmitted helminthiasis -- are all coendemic in Nigeria. The World Health Orga

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31

Miley, Kristi M. "The Effect of Antigen Polymorphisms on Serological Antibody Detection Assays Based Upon the." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6904.

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Onchocerca volvulus is a filarial parasite transmitted to humans by female Simulium spp. black flies. Infection with this parasite can cause blindness and severe skin disease among humans in Africa and the Americas. Enzyme-linked Immunosorbent Assay serological testing of OV-16 antigen is a diagnostic tool for determining effective elimination of the parasite. Programs typically rely on OV–16 ELISA to evaluate the progress towards interruption and/or elimination of disease by mass drug distribution of ivermectin and vector larvicidal control efforts. As elimination grows closer, monoclonal ant

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32

Eng, Jeffrey K. L. "Genetic selection by ivermectin on Onchocerca volvulus." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111844.

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Onchocerca volvulus is a parasitic filarial nematode responsible for human onchocerciasis, a disease commonly known as "River Blindness". Although there are no well documented cases of ivermectin resistance in O. volvulus, reports of suboptimal responses to ivermectin have appeared. The purpose of this thesis was to examine genetic polymorphisms in O. volvulus and to determine whether there was genetic evidence of ivermectin selection on O. volvulus genes. Analysis of 17 genes from O. volvulus was undertaken in two populations of worms, either from ivermectin-naive patients or from patients wh

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33

Bourguinat, Catherine. "Effects of ivermectin on Onchocerca volvulus adult worms." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111889.

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Ivermectin (IVM) is the only safe drug for mass-treatment of onchocerciasis. IVM-resistance has been reported in gastrointestinal nematode parasites of animals. A reduction in response to IVM in Onchocerca volvulus could have significant consequences for the onchocerciasis control programs. Over the last few years, studies have reported genetic selection or reduced responses to IVM in some O. volvulus populations. The risk of a recrudescence of the disease was recently reported with the emergence of resistant adult parasite population in Ghana. It is important to understand the effects of IVM

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34

York, Kathie J. "The Community Health Workers' Role in the Community-Directed Treatment with Ivermectin Program in the Morogoro Rural District of Tanzania." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1323349445.

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35

Benalcázar, Ana Lucía Moncayo. "Impacto del tratamiento en masa a largo plazo con ivermectina en la infección por geohelmintos en el nroeste de Ecuador." Programa de pós-graduação em saúde coletiva, 2008. http://www.repositorio.ufba.br/ri/handle/ri/10350.

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36

Albers, Anna Christina [Verfasser]. "Evaluation of Wolbachia depletion after antibiotic treatment using real-time PCR in Onchocerciasis and Lymphatic Filariasis, and analysis of genetic associations in Lymphatic Filariasis / Anna Christina Albers. Mathematisch-Naturwissenschaftliche Fakultät." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1017217149/34.

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37

Gentil, Katrin [Verfasser]. "Ocular onchocerciasis : the role of Toll-like receptor-2 and Interferon-γ [Interferon-gamma] / vorgelegt von Katrin Gentil". 2010. http://d-nb.info/1002624975/34.

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38

Forte, José Augusto Gil Martinho. "Estudo clínico da oncocercose na Guiné-Bissau." Doctoral thesis, 2007. http://hdl.handle.net/10362/5506.

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Em África e no Sul da Arábia, a oncocercose está essencialmente associada ao complexo Simulium damnosum (Ovazza, 1967). A propagação da doença resulta essencialmente do tipo de actividade humana, e das alterações do ambiente, especìalmente a desflorestação maciça, transformando o habitat florestal em habitat de savana (Hocking, 1953, Dadzie, 1980, Amazigo, 1991, Amazigo, 2002 a, WHO, 1995 b). 2- Morfologia 2.1 - O ovo O ovo, têm uma forma triangular, com os vértices arredondados, medindo de 0,1 a 0,5 mm de comprimento. A casca é lisa, não apresentando qualquer adaptação especial e o

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39

Lobos, Edgar. "Molecular and immunological studies on filariasis : development of a specific and early diagnosis of onchocerciasis (river blindness) and the role of g-glutamyl [gamma-glutamyl] transpeptidase in the pathogenesis of tropical pulmonary eosinophilia syndrome (TPE) /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013359418&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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