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Journal articles on the topic 'Oncocytic'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Palamarchuk, V. O., N. V. Smolovik, N. V. Kuts, and O. A. Tovkai. "Oncocytic cells in the punctate of a thyroid gland nodule. Is there a reason to suspect cancer." Clinical Endocrinology and Endocrine Surgery, no. 3 (September 30, 2024): 4–9. http://dx.doi.org/10.30978/cees-2024-3-4.

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Oncocytic metaplasia can occur in various thyroid conditions. Individual cells, follicles, or groups of follicles may show signs of oncocytic metaplasia, such as in irradiated thyroid gland, nodular goiter, and chronic lymphocytic thyroiditis, as well as in long‑term autoimmune hyperthyroidism (Graves’ disease). Malignant nodes from oncocytic cells are even rarer. According to the world literature, the prevalence of oncocytic carcinoma (OC) among all thyroid cancers is from 3% to 5%. Among nodes that had oncocytic cells in the cytological sample, oncocytic carcinoma is detected in 5.0—49.1% of

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2

Sarode, Gargi S., Sachin C. Sarode, Monal Yuwanati, and Kedar Vaidya. "Predominantly oncocytic mucoepidermoid carcinoma of palate: A case report." Journal of Oral and Maxillofacial Pathology 28, no. 1 (2024): 134–37. http://dx.doi.org/10.4103/jomfp.jomfp_332_23.

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Oncocytic mucoepidermoid carcinoma (OMEC) is an uncommon variant of mucoepidermoid carcinoma. Histopathologically, it is characterised by the predominance of cells with large polygonal morphology and with an abundance of eosinophilic granules. We present a rare case of OMEC manifested as painless palatal swelling in a 25-year-old young male. The overlying mucosa was normal in appearance, with no evidence of ulceration or discharge. Histopathology examination showed the presence of sheets of mucous and intermediate cells along with cystic areas of variable sizes and shapes. On high power magnif

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3

Capone, Randolph B., Patrick K. Ha, William H. Westra, et al. "Oncocytic Neoplasms of the Parotid Gland: A 16-Year Institutional Review." Otolaryngology–Head and Neck Surgery 126, no. 6 (2002): 657–62. http://dx.doi.org/10.1067/mhn.2002.124437.

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BACKGROUND: Oncocytic neoplasms of the parotid gland are a rare collection of salivary gland tumors that include oncocytosis, oncocytoma, and oncocytic carcinoma. Mounting evidence has linked the presence of oncocytes to acquired mitochondrial dysfunction. OBJECTIVES: The study goals were to further delineate this poorly understood group of salivary gland tumors and to search for genetic alterations indicative of mitochondrial dysfunction. METHODS: Cases were identified by search of the surgical pathology archival files from 1984 through 2000. Corresponding medical records were reviewed. Tumor

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4

Mayer, Doris, Edgar Weber, Bernhard Kadenbach, and Peter Bannasch. "Immunocytochemical Demonstration of Cytochrome c Oxidase as a Marker for Renal Oncocytes and Oncocytomas." Toxicologic Pathology 17, no. 1_part_1 (1989): 46–49. http://dx.doi.org/10.1177/01926233890171p107.

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Using an antibody raised against the mitochondrial enzyme cytochrome c oxidase (EC 1.9.3.1), it was possible to visualize microoncocytomas, oncocytic tubules and even single oncocytes in the renal cortex of rats treated with N-nitrosomorpholine, and to localize the lesions to the collecting duct of the nephron. In human specimens, the antibody also stained oncocytomas and oncocytic tubules in the surrounding macroscopically unaffected cortex. Thus, this antibody may be used for detection as well as for investigation of the development of oncocytic lesions in various species.

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Mandic, Robert, Abbas Agaimy, Daniel Pinto-Quintero, et al. "Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors." Cancers 12, no. 5 (2020): 1112. http://dx.doi.org/10.3390/cancers12051112.

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The Warthin tumor represents the second most frequent benign tumor of the parotid gland and is characterized by the presence of oncocytes rich in structurally and functionally altered mitochondria. Next to its role in metabolism, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is also implicated in cellular mitophagy. Immunohistochemistry was carried out on Warthin tumor and normal control (parotid gland with striated ducts) tissues, using anti-GAPDH specific antibodies followed by digital image analysis. Laser capture microdissection was used to isolate the oncocytic tumor cell and normal co

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6

Pontoriero, Antonio, Paola Critelli, Marco Zeppieri, et al. "Low Radiation Doses in Oncocytic Lesions of the Parotid Gland: A Double-edged Sword. A Comprehensive Review." Annali Italiani di Chirurgia 95, no. 4 (2024): 510–21. http://dx.doi.org/10.62713/aic.3360.

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Oncocytic lesions represent a group of benign and potentially precancerous tumors characterized by the accumulation of oncocytes, which are large, granular, and eosinophilic cells. Diagnosing oncocytic lesions in the parotid gland typically involves a combination of imaging techniques, such as ultrasound, Computed Tomography (CT) scans, and Magnetic Resonance Imaging (MRI). Fine-needle aspiration (FNA) biopsy with histopathological examination remains the primary diagnostic tool for these lesions. Accurate diagnosis is crucial for appropriate management decisions. Treatment options for oncocyt

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7

Dhingra, J. K., N. M. Aqel, J. McEwen, and N. R. Bleach. "Multiple oncocytic cysts of the larynx." Journal of Laryngology & Otology 109, no. 12 (1995): 1226–28. http://dx.doi.org/10.1017/s0022215100132529.

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AbstractOncocytic metaplasia in laryngeal epithelium is uncommon. Oncocytes have been described in the lining of laryngeal cysts and such cysts have been reported in the literature under a variety of names. There is an ongoing debate about the exact nature of ‘oncocytic cysts’, which tend to be solitary. An unusual case of multiple oncocytic cysts of the larynx is described. The pathology and treament are discussed.

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8

Boot, Madison, and Abdul Lathif. "A case of an oncocystic laryngeal cyst: A rare pathology." Journal of Case Reports and Images in Otolaryngology 5, no. 2 (2025): 1–3. https://doi.org/10.5348/100012z18mb2024cr.

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Introduction: Oncocytic cysts of the larynx are rare benign lesions characterized by slow growth and large polygonal oncocytic cells. They are primarily found in the supraglottic area and ventrals, with a prevalence of 0.5–1% in laryngeal biopsies. Case Report: A 75-year-old female presented with progressive dysphonia for eight months, with no other significant symptoms. Examination revealed a pedunculated polypoidal mass on the right false vocal cord. Imaging confirmed a well-defined lesion. Microlaryngoscopy and excision biopsy revealed an oncocytic cyst, leading to symptom improvement post-

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9

Kogan, E. А., Y. I. Osmanov, V. I. Shchekin, G. А. Demyashkin, and A. V. Kaem. "MORPHOLOGICAL FEATURES AND IMMUNOPHENOTYPIC ASPECTS OF HYBRID KIDNEY TUMOR." Crimea Journal of Experimental and Clinical Medicine 10, no. 2 (2020): 13–21. http://dx.doi.org/10.37279/2224-6444-2020-10-2-13-21.

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A hybrid oncocytic/chromophobic tumor or a low malignant oncocytic tumor is not officially included in the clas- sification of 2016 WHO kidney tumors, however, in the literature, some authors consider this tumor as an independent nosological unit. A number of authors describe a hybrid oncocytic / chromophobic tumor consisting exclusively of relatively small oxyphilic cells resembling both oncocytes and chromophobic renal carcinoma cells at the same time. The development of morphological and immunohistochemical criteria for a hybrid oncocytic / chromophobic tumor is an important link in the dif

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10

Khalele, Bacem, and Alena Skalova. "Abstract 2492: Diagnostic algorithm for salivary gland oncocytic lesions." Cancer Research 85, no. 8_Supplement_1 (2025): 2492. https://doi.org/10.1158/1538-7445.am2025-2492.

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Abstract Aim: Diagnosing salivary gland lesions with oncocytic differentiation is challenging as it encompassing 21 reactive and neoplastic lesions. With the extensive differentiation, morphological overlapping is possible especially that some tumors can be purely oncocytic. We propose a diagnostic algorithm based on analyzing oncocytic detection in the salivary gland lesion in AS’ registry (501 out of 6383 SGL) to propose a differential diagnosis based on morphology, immunohistochemistry, and molecular findings. Methods: We developed a weighted probabilistic scoring algorithm incorporating di

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Kumar, Rammohan, Srikant Natarajan, K. S. Sneha, Nunna Sai Chitra, Karen Boaz, and Nidhi Manaktala. "Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges." Case Reports in Dentistry 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/5741821.

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The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of t

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Gupta, D., W. Smith, M. Shaar, and D. Baloi. "A Case Series of a Rare Parotid Gland Oncocytic Mucoepidermoid Carcinoma." American Journal of Clinical Pathology 162, Supplement_1 (2024): S71. http://dx.doi.org/10.1093/ajcp/aqae129.157.

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Abstract Introduction/Objective We analyzed two cases of oncocytic mucoepidermoid carcinoma (OMEC) of the parotid gland which highlight the diagnostic challenges of oncocytic salivary gland neoplasms. OMEC’s are a rare type of salivary gland tumor commonly arising from the parotid gland that can easily be mistaken as benign. Proper pathologic diagnosis of these masses is critical, as it guides therapeutic intervention and has prognostic significance. Methods/Case Report In this case series, two patients were analyzed retrospectively for unilateral parotid masses. Results (if a Case Study enter

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Poller, David N., Hakim Megadmi, Matthew J. A. Ward, and Pierpaolo Trimboli. "Hürthle Cells on Fine-Needle Aspiration Cytology Are Important for Risk Assessment of Focally PET/CT FDG Avid Thyroid Nodules." Cancers 12, no. 12 (2020): 3544. http://dx.doi.org/10.3390/cancers12123544.

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This study assesses the role of [18F] FDG PET/CT, fine needle aspiration (FNA) cytology and ultrasound in the 1–2% of patients with focally positive thyroid nodules on FDG PET/CT. All FDG PET/CT scans with focally increased thyroid FDG PET/CT uptake performed over 37 months in one institution were matched to patients undergoing thyroid FNA. Diffuse FDG PET/CT uptake patients were excluded. A total of 47 patients showed focally increased thyroid uptake. Consistent with previous studies, 18 (38.2%) patients had malignancy—12 primary thyroid carcinoma, 1 parathyroid carcinoma, 3 metastatic carcin

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14

Seethala, Raja R., Jeffrey A. Richmond, Aaron P. Hoschar, and E. Leon Barnes. "New Variants of Epithelial-Myoepithelial Carcinoma: Oncocytic-Sebaceous and Apocrine." Archives of Pathology & Laboratory Medicine 133, no. 6 (2009): 950–59. http://dx.doi.org/10.5858/133.6.950.

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Abstract Context.—Recently described variants of epithelial-myoepithelial carcinoma have not been well characterized but raise a distinct set of differential diagnostic considerations than the classic type. Objective.—To report a detailed analysis of oncocytic-sebaceous epithelial-myoepithelial carcinoma (OEMCa) and a similar, but novel, variant, apocrine epithelial-myoepithelial carcinoma (ApEMCa). Design.—Clinical, histologic, and immunophenotypic features of 5 OEMCas and 5 ApEMCas were analyzed. Ultrastructural examination was also performed on 3 OEMCa and 1 ApEMCa tumors. Results.—The mean

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15

Gvianishvili, Tamuna. "Oncocytic Cell Activity in Hashimoto’s Thyroiditis and PTC Thyroid Parenchyma: Immunohistochemical Profile." Japan Journal of Clinical & Medical Research 3, no. 3 (2023): 1–3. http://dx.doi.org/10.47363/jjcmr/2023(3)155.

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Oncocytic cell neoplasia makes a challenge in diagnosis and treatment, because It’s known that oncocytic cell neoplasms have unique molecular mechanisms. Oncocytic cells can be seen in many types of thyroid disease, including benign tumors, low-risk neoplasms, and malignant neoplasms. Thyroid tumors are classified as oncocytic cell neoplasms when more than 75% of the tumor consists of oncocytic cells. We studied oncocytic cells in cases of Hashimoto’s thyroiditis and Papillary Thyroid Carcinoma with different markers (Protein S-100, CD56, p63 and Cyclin D1). Based on the obtained results, we c

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16

Niveiro, María, Francisco Ignacio Aranda, Artemio Payá, Evangelina Boix, Gloria Peiró, and Antonio Picó. "Oncocytic Transformation in Pituitary Adenomas: Immunohistochemical Analyses of 65 Cases." Archives of Pathology & Laboratory Medicine 128, no. 7 (2004): 776–80. http://dx.doi.org/10.5858/2004-128-776-otipai.

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Abstract Context.—Oncocytic change in pituitary adenomas has been evaluated by electron microscopy and more recently by immunohistochemistry. The clinical significance of this change is not well known, although some reports suggest a relationship with more aggressive behavior. Objective.—To assess the frequency of oncocytic change in pituitary adenomas and to correlate this finding with clinicopathologic factors. Design.—We studied oncocytic change in a series of 65 pituitary adenomas by immunohistochemistry. According to the percentage of oncocytic cells stained by antimitochondrial antibody,

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17

Sato, Fuyuki, Takashi Nakajima, and Takashi Sugino. "Complex Component of Oncocytic and Non-Oncocytic Lipoadenomas in the Parotid Gland: A Case Report." Diagnostics 11, no. 8 (2021): 1478. http://dx.doi.org/10.3390/diagnostics11081478.

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Oncocytic lipoadenoma of the salivary gland is a rare tumor that develops mainly in the parotid gland. We report a case of oncocytic lipoadenoma of the parotid gland in a 70-year-old woman. The tumor measured 30 × 20 mm and had a well-circumscribed tan-brown surface. The tumor was histologically composed of oncocytic and lipomatous lesions without atypia. In addition to the oncocytic lipoadenoma, a small lipomatous tumor, measuring 10 × 7 mm, was found in the resected parotid gland. Macroscopically, this tumor was yellow and indistinguishable from the parotid gland. Microscopically, the tumor

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18

Huang, Chien-Peng, Ming-Shen Dai, Chien-Chang Kao, Wen-Chiuan Tsai, and Cheng-Ping Yu. "A Case of Oncocytic Adrenal Cortical Neoplasm with Uncertain Malignant Potential Turned Out to Be Oncocytic Adrenal Cortical Carcinoma with Distant Metastasis: Could Pathology Do Better Initially?" Medicina 58, no. 7 (2022): 900. http://dx.doi.org/10.3390/medicina58070900.

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Oncocytic adrenal cortical neoplasms are rare cases and are divided into oncocytoma, oncocytic neoplasms of uncertain malignant potential and oncocytic adrenal cortical carcinomas, based on the Lin–Weiss–Bisceglia (LWB) histological system adopted in the current World Health Organization (WHO). We reported a 42-year-old female diagnosed with an oncocytic neoplasm of uncertain malignant potential initially, which turned out to be a carcinoma owing to distant metastasis to the scalp and lung. To our knowledge, this is the first published case of oncocytic adrenal cortical carcinoma with scalp me

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Lumintang, Nico, Sherly Tandililing, and Calenthia Ekawati. "Oncocytic Carcinoma of Parotid Gland: A Case Report." e-CliniC 11, no. 2 (2023): 243–45. http://dx.doi.org/10.35790/ecl.v11i2.46277.

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Oncocytic carcinoma is a rare malignant carcinoma, representing only 5% of all oncocytic tumors. Furthermore, oncocytic carcinoma of the parotid gland is uncommon, accounting only for under 1% of all salivary gland tumors. We reported an 82-year-old female presented with a right parotid mass. She had experienced a similar complaint six months ago and had undergone treatment. Physical examination showed a mobile and painless cystic mass of the right parotid without facial nerve involvement. Fine needle aspiration biopsy (FNAB) finding suggested benign cystic lesions with inflammatory cells and

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20

Rathod, Gunvanti, Sai Swetha Banka, Monica Mishra, and Pragnesh Parmar. "A short communication on Oncocytic Lesions of the Thyroid gland." International Archives of Integrated Medicine 12, no. 5 (2025): 9–12. https://doi.org/10.5281/zenodo.15525906.

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Oncocytic lesions of the thyroid, often referred to as Hurthle cell lesions or oncocytic changes, represent a subset of thyroid pathologies characterized by mitochondrial-rich, eosinophilic cytoplasm. Oncocytic lesions of the thyroid are covering a wide spectrum of lesions e.g. benign hyperplastic nodules to malignant thyroid neoplasms. It is very important to understand their biology, diagnostic challenges, and management strategies for clinicians as well as pathologists alike. The most common clinical presentation of patients with oncocytic thyroid lesions is a painless thyroid nodule which

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21

Ferreiro, Jorge A., and Nickolaos Stylopoulos. "Oncocytic differentiation in salivary gland tumours." Journal of Laryngology & Otology 109, no. 6 (1995): 569–71. http://dx.doi.org/10.1017/s0022215100130749.

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AbstractAn oncocytic mucoepidermoid carcinoma and an oncocytic pleomorphic adenoma occurred in a 47-year-old male and a 75-year-old female, respectively. Both presented as asymptomatic parotid gland masses without evidence of facial nerve paralysis and were treated by superficial parotidectomy. There has been no evidence of recurrence or metastasis. Oncocytic change is rare in major salivary gland mucoepidermoid carcinoma with only two previously reported cases. Marked oncocytic transformation of pleomorphic adenomas can cause their confusion with oncocytomas. Recognition of oncocytic differen

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22

Weber, Tina, Wolfgang Saeger, and Dieter K. Lüdecke. "Light microscopical morphometry, immunocytochemistry, and clinical correlations of pituitary adenomas at various stages of oncocytic transformation." Acta Endocrinologica 116, no. 4 (1987): 489–96. http://dx.doi.org/10.1530/acta.0.1160489.

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Abstract. In a series of 124 pituitary adenomas displaying oncocytic alterations, we studied the degree of oncocytic transformation by light microcopical and morphometrical means for semiquantitative analysis. We established three groups with different percentages of oncocytically transformed cells for comparison of clinical and immunocytochemical data. Of the patients, 32.3% exposed adenomas with less than 50% oncocytic alterations (group I), whereas 22.6% showed tumours with oncocytic transformations between 51% and 75% (group II). Oncocytic parts consisting of more than 75% of the tumour ce

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López-Terrada, Dolores, M. G. K. Bloom, Philip T. Cagle, and Mary L. Ostrowski. "Oncocytic Mucoepidermoid Carcinoma of the Trachea." Archives of Pathology & Laboratory Medicine 123, no. 7 (1999): 635–37. http://dx.doi.org/10.5858/1999-123-0635-omcott.

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Abstract We report a rare case of an oncocytic mucoepidermoid carcinoma of the trachea, which presented in a 78-year-old woman with hemoptysis. Oncocytic cells comprised the majority of this low-grade lesion and demonstrated granular cytoplasmic phosphotungstic acid–hematoxylin staining as well as strong immunohistochemical reactivity to antimitochondrial antibody. Most tracheobronchial tumors with oncocytic change are carcinoid tumors. To our knowledge, this is the first oncocytic mucoepidermoid carcinoma of the trachea reported. This diagnosis was facilitated by histochemical and immunohisto

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Roncaroli, Federico, Luca Riccioni, Michele Cerati, et al. "Oncocytic Meningioma." American Journal of Surgical Pathology 21, no. 4 (1997): 375–82. http://dx.doi.org/10.1097/00000478-199704000-00002.

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Donner, Ludvik R., and Valdemar Maximo. "Oncocytic Melanoma." American Journal of Dermatopathology 40, no. 11 (2018): 854–56. http://dx.doi.org/10.1097/dad.0000000000001183.

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Saliba, Michel Cyrino, Vinícius Antunes Freitas, Eduardo César Dolabela de Moraes, Fabrícia Leandro de Barros, and Roberto Eustáquio Santos Guimarães. "Oncocytic Papilloma." Brazilian Journal of Otorhinolaryngology 75, no. 2 (2009): 317. http://dx.doi.org/10.1016/s1808-8694(15)30797-7.

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Tallini, Giovanni. "Oncocytic tumours." Virchows Archiv 433, no. 1 (1998): 5–12. http://dx.doi.org/10.1007/s004280050209.

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Al Badi, Maryam K., Ibrahim Al-Alwan, Mohammed Al-Dubayee, et al. "Testosterone- and Cortisol-secreting Oncocytic Adrenocortical Adenoma in the Pediatric Age-group." Pediatric and Developmental Pathology 21, no. 6 (2018): 568–73. http://dx.doi.org/10.1177/1093526617753045.

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Oncocytic tumors are epithelial neoplasms that occur in various organs, including adrenal glands. Oncocytic adrenocortical adenomas and carcinomas are uncommon but well-known pathological entities in adults. However, generally oncocytic tumors, particularly in the adrenal glands, are very rare in the pediatric age-group. Most oncocytic adrenal tumors are not functional. We present a rare case of right-sided, functional oncocytic adrenocortical adenoma in a 5-year-old boy, who presented with clinical manifestations of precocious puberty and Cushing syndrome. Laparoscopic adrenalectomy showed a

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Patnaik, Nivedita, Preeti Diwaker, Alphy Varughese, Vinod Arora, and Bharat Singh. "Cytomorphological features of oncocytic variant of papillary thyroid carcinoma with lymphocytic thyroiditis." Asian Journal of Oncology 02, no. 02 (2016): 085–87. http://dx.doi.org/10.4103/2454-6798.197377.

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AbstractCytological diagnosis of hurthle cell lesions of thyroid is a diagnostic dilemma. Presence of hurthle cells on fine needle aspiration (FNA) leads to a wide range of differential diagnosis including benign and malignant entities. The oncocytic variant of papillary thyroid carcinoma (PTC) is one entity of the vast list of differentials of which very few cases have been reported to date. We report a case of oncocytic variant of PTC in a 28-year-old female diagnosed on cytomorphology. The findings of FNA smears of the first aspirate were not sufficient for a definitive diagnosis. Repeat FN

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Hwang, Joshua C., Raj D. Dedhia, Joan E. Bernard, and Toby O. Steele. "Oncocytic Cysts of the Nasopharynx: A Case Report." Allergy & Rhinology 11 (January 2020): 215265672095659. http://dx.doi.org/10.1177/2152656720956594.

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Background Nasopharyngeal oncocytic lesions are a spectrum of benign lesions that represent a reactive or hyperplastic response to chronic inflammation. Though oncocytic lesions are typically asymptomatic, unilateral, and benign, this article discusses a rare case of large, bilateral oncocytic cysts and downstream otologic sequelae with a focus on identifying and discussing similar disease processes. Methods Case report and literature review. Case Presentation: A 67-year-old patient with 57 pack year smoking history presented for one year of left sided hearing loss and aural fullness. Clinic e

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Tokashiki, Kunihiko, Kiyoaki Tsukahara, Ray Motohashi, Kazuhiro Nakamura, and Mamoru Suzuki. "A Case of Primary Submandibular Gland Oncocytic Carcinoma." Case Reports in Otolaryngology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/384238.

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Primary submandibular gland oncocytic carcinoma is a rare pathology, with only 10 cases being reported to date. We encountered a case of primary submandibular gland oncocytic carcinoma and report it herein. The patient was a 69-year-old man who came to our hospital with right submandibular cancer as the main complaint. Based on the results of computed tomography and magnetic resonance imaging, submandibular gland tumor was diagnosed. Preoperative cytodiagnosis suggested class III oncocytic carcinoma. Resection of the right submandibular tumor was performed along with right neck dissection. Pos

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Wakely, Paul E. "Oncocytic and oncocyte-like lesions of the head and neck." Annals of Diagnostic Pathology 12, no. 3 (2008): 222–30. http://dx.doi.org/10.1016/j.anndiagpath.2008.04.007.

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Patil, Soniya A., Raji T. Naidu, Uma P. Chaturvedi, and Prachi R. Gaddam. "Oncocytic Lipoadenoma of the Parotid Gland against a Background of Multifocal Oncocytic Hyperplasia: Report of a Rare Case." Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, no. 5 (2024): 1084–86. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_356_23.

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ABSTRACT Oncocytic lipoadenoma is an extremely rare benign salivary gland tumor with only few cases reported in the literature. We herein report a case of oncocytic lipoadenoma originating in the parotid gland of a 65-year-old man. The tumor presented as a slowly growing asymptomatic right-sided parotid gland mass. On MRI, right parotid showed a 40 × 32 × 20 mm well-encapsulated, neoplastic mass in the superficial lobe. On core biopsy, differentials considered were nodular oncocytosis and oncocytoma. Subsequently, superficial parotidectomy was performed. The resected tumor was encapsulated, ye

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Nguyen, Sally, Marjorie Perron, Sylvie Nadeau, Alexandre Nakao Odashiro, and Marie-Noëlle Corriveau. "Epithelial Myoepithelial Carcinoma of the Nasal Cavity: Clinical, Histopathological, and Immunohistochemical Distinction of a Case Report." International Journal of Surgical Pathology 26, no. 4 (2017): 342–46. http://dx.doi.org/10.1177/1066896917747732.

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Background. Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma. Methods. Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei. Immunohistochemical stains demonstrated biphasic cells: luminal epithelial and basal cell–type myoepithelial cells. Th

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Curso, Krystal April Joy, John Carlo Reyes, Jonathan Rivera, and Jose Carnate. "Warthin-like Variant of Mucoepidermoid Carcinoma of the Parotid Gland." Philippine Journal of Otolaryngology Head and Neck Surgery 39, no. 1 (2024): 55. http://dx.doi.org/10.32412/pjohns.v39i1.2325.

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A 57-year-old woman with a 2-year history of a left infra-auricular mass with no associated symptoms presented with a 6.0 cm ´ 4.0 cm ´ 3.0 cm firm, non-tender, movable mass. No imaging was done. Fine needle aspiration biopsy (FNAB) revealed sheets of epithelial cells that had abundant dense grayish-blue cytoplasm in a mucinous background with abundant lymphocytes (Figure 1), suggestive of salivary gland neoplasm with oncocytic or oncocytoid features (Category IVB, Salivary Gland Neoplasm of Uncertain Malignant Potential).1 Total parotidectomy revealed a 4.3 X 3.2 X 3.0 cm deep lobe lesion wit

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Puttasiddaiah, Paramesh M., Sandeep Berry, Heikki B. Whittet, and Manoj Kumar. "Laryngeal Oncocytic Cyst Presenting with an Acute Onset of Stridor." Ear, Nose & Throat Journal 88, no. 7 (2009): 1003–4. http://dx.doi.org/10.1177/014556130908800709.

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Oncocytic lesions of the larynx are rare. When they have occurred, their presentation has been varied; these tumors may he completely asymptomatic and discovered incidentally, hut more commonly they present with voice alteration. We report a case of an oncocytic cyst in a patient who presented with an acute onset of stridor. We also discuss the clinical manifestations and management of laryngeal oncocytic cyst and its relevant pathologic features.

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Culp, Stephen Hembree, Yunchuan Delores Mo, Mairo Diolombi, and Helen P. Cathro. "Classification of oncocytic papillary renal cell carcinoma." Journal of Clinical Oncology 31, no. 6_suppl (2013): 467. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.467.

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467 Background: Over the past decade, genitourinary pathologists have increasingly recognized an oncocytic variant of papillary renal cell carcinoma (PRC) that can complicate classification as Type 1 or Type 2 PRC. The International Society of Urological Pathology recently proposed reclassifying oncocytic papillary renal cell carcinoma (OPRC) as a separate subtype. We set out to test the validity of separating oncocytic tumors from other PRC. Methods: 70 consecutive cases of PRC with sufficient tissue for analysis were reviewed from patients undergoing surgery at The University of Virginia (19

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Chinelli, Javier, Gustavo Rodríguez, and Elisa Laca. "Oncocitoma suprarrenal." Revista Argentina de Cirugía 111, no. 3 (2019): 175–79. http://dx.doi.org/10.25132/raac.v111.n3.1396.es.

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Oncocytic adrenocortical carcinoma is an extremely rare tumor, with only 150 cases reported in the literature. A 48-year-old male patient, with right adrenalectomy due to a 7-cm non-functional adrenal inciden- taloma. From a clinical imaging point of view, oncocytic adrenocortical carcinoma cannot be distinguished from other more common adrenal tumors; therefore, the diagnostic confirmation is histological. It is rarely malignant, and the accepted treatment is laparoscopic adrenalectomy. In our case, two minor histological criteria classify it as a potentially malignant tumor.

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Varma, V. A., C. M. Cerjan, K. L. Abbott, and S. B. Hunter. "Non-isotopic in situ hybridization method for mitochondria in oncocytes." Journal of Histochemistry & Cytochemistry 42, no. 2 (1994): 273–76. http://dx.doi.org/10.1177/42.2.8288868.

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We used in situ hybridization to specifically identify mitochondria in a series of formalin-fixed, paraffin-embedded oncocytic lesions. Digoxigenin-labeled DNA probes were generated by the polymerase chain reaction (PCR), with primers designed to amplify a mitochondrion-specific 154 BP sequence within the ND4 coding region. Probes were hybridized with mitochondrial DNA under stringent conditions. Oncocytes were strongly and consistently stained, reflecting the high copy number of mitochondrial DNA within these cells. Because of the presence of endogenous biotin within mitochondria, digoxigenin

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YAPRAK, Neslihan, Mehmet AŞIK, Murat TURHAN, Havva Serap TORU, and İrem Hicran ÖZBUDAK. "Oncocytic Schneiderian Papilloma." Akdeniz Medical Journal 1, no. 2 (2015): 113–16. http://dx.doi.org/10.17954/amj.2015.21.

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Lin, Bryan T. Y., Stephen M. Bonsib, Gary W. Mierau, Lawrence M. Weiss, and L. Jeffrey Medeiros. "Oncocytic Adrenocortical Neoplasms." American Journal of Surgical Pathology 22, no. 5 (1998): 603–14. http://dx.doi.org/10.1097/00000478-199805000-00012.

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Li, Maomi, and Bruce M. Wenig. "Adrenal Oncocytic Pheochromocytoma." American Journal of Surgical Pathology 24, no. 11 (2000): 1552–57. http://dx.doi.org/10.1097/00000478-200011000-00013.

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Bisceglia, Michele, David Ben-Dor, and Gianandrea Pasquinelli. "Oncocytic Adrenocortical Tumors." Pathology Case Reviews 10, no. 5 (2005): 228–42. http://dx.doi.org/10.1097/01.pcr.0000175102.22075.54.

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Weinreb, Ilan, Raja R. Seethala, Bayardo Perez-Ordoñez, Runjan Chetty, Aaron P. Hoschar, and Jennifer L. Hunt. "Oncocytic Mucoepidermoid Carcinoma." American Journal of Surgical Pathology 33, no. 3 (2009): 409–16. http://dx.doi.org/10.1097/pas.0b013e318184b36d.

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Duregon, Eleonora, Marco Volante, Susanna Cappia, et al. "Oncocytic Adrenocortical Tumors." American Journal of Surgical Pathology 35, no. 12 (2011): 1882–93. http://dx.doi.org/10.1097/pas.0b013e31822da401.

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Hes, Ondrej, and Michal Michal. "Renal Oncocytic Angiomyolipoma." International Journal of Surgical Pathology 12, no. 4 (2004): 421–22. http://dx.doi.org/10.1177/106689690401200419.

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Xiao, Hai, Tingyu Wen, and Xinzheng Liu. "Submandibular oncocytic carcinoma." Medicine 95, no. 37 (2016): e4897. http://dx.doi.org/10.1097/md.0000000000004897.

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McKenney, Jesse K. "Oncocytic renal neoplasia." Pathology 49 (February 2017): S7—S8. http://dx.doi.org/10.1016/j.pathol.2016.12.012.

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Franciosi, Ralph A., and Amarjit Singh. "Oncocytic cardiomyopathy syndrome." Human Pathology 19, no. 11 (1988): 1361–62. http://dx.doi.org/10.1016/s0046-8177(88)80296-x.

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Tanaka, Kazushi, Yoshifumi Kumano, Naoki Kanomata, et al. "Oncocytic adrenocortical carcinoma." Urology 64, no. 2 (2004): 376–77. http://dx.doi.org/10.1016/j.urology.2004.04.023.

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